Qing Fei Pai Du Tang

Lung-Clearing Toxin-Expelling Decoction · 清肺排毒湯

Also known as: Qingfei Paidu Tang, QFPDT, Qing Fei Pai Du Granules (清肺排毒颗粒)

A modern composite formula developed during the COVID-19 pandemic to address respiratory infections caused by cold, dampness, and toxic pathogenic factors. It combines four classical formulas from the 2,000-year-old Shang Han Lun to open the Lungs, resolve dampness, clear heat, and expel toxins. Designed for use in acute febrile respiratory illness with cough, fatigue, and chest tightness.

Origin New formula created in January 2020 by Ge Youwen (葛又文), a special researcher at the China Academy of Chinese Medical Sciences, combining and modifying classical formulas from Zhang Zhongjing's Shang Han Za Bing Lun (伤寒杂病论). Officially recommended by the National Health Commission and National Administration of Traditional Chinese Medicine on February 6, 2020. — Modern, 2020 CE (based on Hàn dynasty classical formulas, ~200 CE)
Composition 21 herbs
Ma Huang
King
Ma Huang
Chai Hu
King
Chai Hu
Shi Gao
Deputy
Shi Gao
Xing Ren
Deputy
Xing Ren
Gui Zhi
Deputy
Gui Zhi
Huang Qin
Deputy
Huang Qin
Fu Ling
Assistant
Fu Ling
Ze Xie
Assistant
Ze Xie
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qing Fei Pai Du Tang is designed to correct these specific patterns.

Why Qing Fei Pai Du Tang addresses this pattern

This is the primary pattern targeted by the formula. In Cold-Damp Pestilence, an epidemic Cold-Damp pathogenic factor invades the Lung, obstructing its dispersing and descending functions. Dampness, being heavy and turbid, clogs the airways and generates phlegm, while Cold constricts the Lung Qi. The result is cough with thin white or frothy sputum, chest tightness, and labored breathing. Ma Huang and Gui Zhi release the exterior and warm the Lung to disperse Cold. Xi Xin penetrates deeply to transform Cold-Thin-Mucus. The Wu Ling San component (Fu Ling, Ze Xie, Zhu Ling, Bai Zhu, Gui Zhi) drains dampness from below while Huo Xiang aromatically transforms it from the Middle Burner. Zi Wan, Kuan Dong Hua, and She Gan dissolve phlegm and restore Lung Qi descent. This multi-layered approach clears dampness from the Lung, Spleen, and Bladder simultaneously.

A practitioner would look for one or more of these signs

Hypochondrial Pain That Is Worse On Coughing And Breathing

Persistent cough with thin white or frothy sputum

Chest Stiffness

Feeling of heaviness and oppression in the chest

Shortness Of Breath

Labored breathing, difficulty taking a full breath

Eye Fatigue

Pronounced fatigue and heavy limbs from dampness obstructing Qi flow

Fever

Low-grade or moderate fever that may be intermittent

Loss Of Appetite

Poor appetite from Spleen impairment by dampness

Nasal Congestion

Blocked nose from Cold obstructing Lung Qi

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Qing Fei Pai Du Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Cold-Dampness Obstructing the Lung Exterior Cold with Interior Heat

TCM Interpretation

TCM understands COVID-19 primarily as an epidemic caused by a Cold-Damp toxic pathogen (寒湿疫毒). This pathogenic factor targets the Lung as its primary organ, but also impairs the Spleen and affects the body's fluid metabolism. The Cold nature of the pathogen constricts Lung Qi and impairs its dispersing function, while the Damp quality generates turbid phlegm that clogs the airways and weighs down the body. As the disease progresses, Cold often transforms into Heat internally, creating a mixed pattern. In severe cases, the pathogen may transmit to multiple organ systems, affecting the Heart, Liver, and Kidneys. The Spleen is considered particularly vulnerable because Dampness is its nemesis, and when the Spleen's transport function fails, fluid accumulation worsens, creating a vicious cycle.

Why Qing Fei Pai Du Tang Helps

Qing Fei Pai Du Tang was specifically designed to match the Cold-Damp Pestilence pathomechanism of COVID-19. Ma Huang, Gui Zhi, and Xi Xin open the Lung, release the exterior, and warm away deeply lodged Cold. Shi Gao and Huang Qin address the Heat that develops as Cold transforms internally. The Wu Ling San component (Fu Ling, Ze Xie, Zhu Ling, Bai Zhu) drains the pathological fluid accumulation that Dampness produces. Huo Xiang aromatically cuts through turbid dampness. Chai Hu and the Xiao Chai Hu Tang component intercept the pathogen at the Shaoyang level, preventing deeper transmission. She Gan, Zi Wan, and Kuan Dong Hua clear phlegm from the airways. Shan Yao and Bai Zhu protect the Spleen to maintain the body's capacity to fight. This comprehensive, multi-target approach explains its broad applicability across mild to severe cases.

Also commonly used for

Upper Respiratory Tract Infections

Common cold or acute viral upper respiratory infections

Bronchitis

Acute bronchitis with productive cough and chest tightness

Hypochondrial Pain That Is Worse On Coughing And Breathing

Persistent cough from respiratory infection

What This Formula Does

Every TCM formula has a specific set of actions — here's what Qing Fei Pai Du Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Qing Fei Pai Du Tang is primarily used to support these areas of health:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Qing Fei Pai Du Tang works at the root level.

Qing Fei Pai Du Tang was designed to address the core disease mechanism of epidemic respiratory illness caused by what TCM classifies as a "cold-damp pestilential toxin" (寒湿疫毒). In this pattern, a virulent external pathogen invades the body through the nose and mouth, first lodging in the Lung system and the body's exterior defense layer. Because the pathogen carries both cold and damp qualities, it behaves differently from a simple Wind-Cold or Wind-Heat invasion: it is heavy, sticky, and difficult to expel, tending to linger and obstruct the normal flow of Qi and fluids.

The Lungs, which govern respiration and the downward movement of fluids, become congested and fail to properly diffuse Qi outward or direct water downward. This produces cough, wheezing, chest tightness, and a sense of heaviness. Simultaneously, the damp component impairs the Spleen's ability to transform and transport fluids, leading to internal accumulation of pathological moisture. This manifests as nausea, poor appetite, loose stools, a thick greasy tongue coating, and generalized fatigue. As the illness progresses, retained dampness can generate Heat through stagnation, creating a complex picture where cold, damp, and heat-toxin coexist at different levels of the body.

The pathogen does not stay at a single level. It may affect the Tai Yang (surface), Shao Yang (half-interior, half-exterior), and Tai Yin (interior Spleen-Lung) simultaneously, which is why the formula draws on prescriptions that address multiple stages of disease progression. The toxin also disrupts the San Jiao's (Triple Burner's) waterways, causing abnormal fluid metabolism throughout the body. This multi-system, multi-level disruption explains why a single classical formula would be insufficient, and why the formula's designer combined several classical prescriptions to address the entire pathological landscape at once.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly pungent and bitter with sweet undertones. The pungent quality opens and disperses (expelling pathogens from the surface and Lungs), the bitter quality clears Heat and dries Dampness, and the sweet quality tonifies the Spleen and harmonizes the other herbs.

Target Organs

Channels Entered

Lung Spleen Stomach Bladder San Jiao Gallbladder

Ingredients

21 herbs

The herbs that make up Qing Fei Pai Du Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Ma Huang

Ma Huang

Ephedra

Dosage 9g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Urinary Bladder, Lungs

Role in Qing Fei Pai Du Tang

Opens the Lung Qi and releases the exterior, dispersing Cold and enabling the expulsion of pathogens through the skin. Restores the Lung's descending and dispersing functions, alleviating cough and wheezing. Serves as the shared core herb of two component formulas (Ma Xing Shi Gan Tang and She Gan Ma Huang Tang).
Chai Hu

Chai Hu

Bupleurum roots

Dosage 16g
Temperature Cool
Taste Bitter
Organ Affinity Gallbladder, Liver

Role in Qing Fei Pai Du Tang

Harmonizes the Shaoyang level and vents pathogenic factors that have penetrated beyond the exterior. Relieves alternating fever and chills, chest and hypochondriac fullness. At 16g, it is the highest-dosed herb in the formula, reflecting its critical role in preventing inward transmission of the pathogen.
Deputies — Assists and enhances the King
Shi Gao

Shi Gao

Gypsum

Dosage 15 - 30g
Temperature Cold
Taste Pungent, Sweet
Organ Affinity Lungs, Stomach
Preparation Must be decocted first (先煎) for at least 30 minutes before adding other herbs

Role in Qing Fei Pai Du Tang

Clears Lung heat and drains interior fire, counterbalancing the warming nature of Ma Huang and Gui Zhi. The flexible dosage (15-30g) allows adjustment based on the degree of fever: lower dose when no fever, higher dose for high fever.
Xing Ren

Xing Ren

Apricot seeds

Dosage 9g
Temperature Warm
Taste Bitter, Sweet
Organ Affinity Large Intestine, Lungs

Role in Qing Fei Pai Du Tang

Directs Lung Qi downward and stops cough. Together with Ma Huang, it forms a classical pair that both disperses and descends Lung Qi, restoring normal respiratory function.
Gui Zhi

Gui Zhi

Cinnamon twigs

Dosage 9g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Heart, Lungs, Spleen

Role in Qing Fei Pai Du Tang

Warms the channels, assists Ma Huang in releasing the exterior, and promotes the movement of Yang Qi. Also transforms Qi in the Bladder to assist water metabolism, linking the exterior-releasing strategy to the fluid-regulating Wu Ling San component.
Huang Qin

Huang Qin

Baikal skullcap roots

Dosage 6g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Large Intestine, Lungs, Small Intestine, Spleen

Role in Qing Fei Pai Du Tang

Clears heat from the Shaoyang and Lung levels. Pairs with Chai Hu in the Xiao Chai Hu Tang component to both vent and clear, preventing the pathogen from sinking deeper while addressing heat that has already formed.
Assistants — Supports or moderates other herbs
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 15g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Qing Fei Pai Du Tang

Strengthens the Spleen and promotes water metabolism through bland percolation. Part of the Wu Ling San component that resolves internal dampness accumulation and supports the Spleen's transport function.
Ze Xie

Ze Xie

Water plantain

Dosage 9g
Temperature Cold
Taste Sweet
Organ Affinity Urinary Bladder, Kidneys

Role in Qing Fei Pai Du Tang

Drains dampness and promotes urination, directing turbid fluids downward and out through the Bladder. A key herb in the Wu Ling San component for clearing accumulated fluid from the body.
Zhu Ling

Zhu Ling

Polyporus

Dosage 9g
Temperature Neutral
Taste Sweet
Organ Affinity Urinary Bladder, Kidneys

Role in Qing Fei Pai Du Tang

Promotes urination and drains dampness, reinforcing the diuretic action of Ze Xie and Fu Ling in the Wu Ling San component. Helps clear pathological fluid accumulation that contributes to chest oppression and breathing difficulty.
Bai Zhu

Bai Zhu

Atractylodes rhizomes

Dosage 9g
Temperature Warm
Taste Bitter, Sweet
Organ Affinity Spleen, Stomach

Role in Qing Fei Pai Du Tang

Tonifies the Spleen and dries dampness, strengthening the body's capacity to transform and transport fluids. Supports the Spleen as the source of Qi production, counteracting the fatigue and poor appetite that accompany the illness.
Ban Xia

Ban Xia

Crow-dipper rhizomes

Dosage 9g
Temperature Warm
Taste Pungent
Organ Affinity Lungs, Spleen, Stomach

Role in Qing Fei Pai Du Tang

Dries dampness and transforms phlegm, descends rebellious Stomach Qi to stop nausea. Part of the Xiao Chai Hu Tang component. The ginger-processed form reduces toxicity while enhancing its phlegm-resolving and anti-nausea effect.
Sheng Jiang

Sheng Jiang

Fresh ginger

Dosage 9g
Temperature Warm
Taste Pungent
Organ Affinity Lungs, Spleen, Stomach

Role in Qing Fei Pai Du Tang

Warms the Middle Burner, disperses Cold, and harmonizes the Stomach. Assists Ma Huang and Gui Zhi in releasing the exterior while supporting digestion. Also helps moderate the cold nature of Shi Gao.
She Gan

She Gan

Blackberry Lily rhizomes

Dosage 9g
Temperature Cold
Taste Bitter
Organ Affinity Lungs

Role in Qing Fei Pai Du Tang

Clears heat and resolves toxins in the throat, disperses phlegm accumulation. The key herb from the She Gan Ma Huang Tang component, specifically targeting throat congestion, swelling, and the sensation of phlegm blocking the airway.
Zi Wan

Zi Wan

Aster roots

Dosage 9g
Temperature Warm
Taste Bitter, Sweet
Organ Affinity Lungs

Role in Qing Fei Pai Du Tang

Moistens the Lungs and directs Qi downward to stop cough and dissolve phlegm. Part of the She Gan Ma Huang Tang component. Effective for both acute and chronic cough with difficult-to-expectorate phlegm.
Kuan Dong Hua

Kuan Dong Hua

Coltsfoot flowers

Dosage 9g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Lungs

Role in Qing Fei Pai Du Tang

Moistens the Lungs, descends Qi, and stops cough. Works in concert with Zi Wan as a classical pair for cough relief, addressing both the acute spasmodic cough and the underlying phlegm congestion in the airways.
Xi Xin

Xi Xin

Wild ginger

Dosage 6g
Temperature Warm
Taste Pungent
Organ Affinity Heart, Kidneys, Lungs

Role in Qing Fei Pai Du Tang

Warms the Lungs and transforms Cold-Thin-Mucus (寒饮), opens the nasal passages, and disperses deeply lodged Cold. Critical for breaking through Cold-Damp obstruction in the Lungs. Part of the She Gan Ma Huang Tang component. Dosed at 6g to ensure adequate strength against the epidemic pathogen.
Shan Yao

Shan Yao

Yam

Dosage 12g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Lungs, Spleen

Role in Qing Fei Pai Du Tang

Tonifies Spleen and Lung Qi and nourishes Yin, providing gentle supplementation to protect the body's righteous Qi during an acute illness. Prevents the strongly dispersing and draining herbs from depleting the Spleen and Lung.
Zhi Shi

Zhi Shi

Immature Bitter Oranges

Dosage 6g
Temperature Cool
Taste Bitter, Pungent, Sour
Organ Affinity Spleen, Stomach, Large Intestine

Role in Qing Fei Pai Du Tang

Breaks Qi stagnation and reduces distension, directing Qi downward. Helps relieve chest and abdominal fullness caused by the accumulation of dampness and phlegm. Ensures smooth Qi flow so that the other herbs can circulate effectively.
Chen Pi

Chen Pi

Tangerine peel

Dosage 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Lungs, Spleen

Role in Qing Fei Pai Du Tang

Regulates Qi and dries dampness, harmonizes the Middle Burner. Assists the Spleen in transforming dampness and prevents the rich, cloying herbs from causing Qi stagnation in the digestive system.
Huo Xiang

Huo Xiang

Korean mint

Dosage 9g
Temperature Warm
Taste Pungent
Organ Affinity Lungs, Spleen, Stomach

Role in Qing Fei Pai Du Tang

Aromatically transforms dampness and turbidity, harmonizes the Middle Burner, and stops nausea. Addresses the core damp-turbid quality of the epidemic pathogen. Its aromatic nature penetrates through turbid dampness that bland diuretics alone cannot resolve.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Liquorice

Dosage 6g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Qing Fei Pai Du Tang

Harmonizes all the herbs in the formula and tonifies Spleen Qi. Moderates the harsh or strongly moving properties of Ma Huang, Shi Gao, and the diuretic herbs, protecting the Stomach. Serves as the envoy that unifies four classical formulas into one cohesive prescription.

Why This Combination Works

How the herbs in Qing Fei Pai Du Tang complement each other

Overall strategy

Qing Fei Pai Du Tang is a composite formula that treats the Cold-Damp Pestilence (寒湿疫) pathomechanism of COVID-19 by simultaneously addressing multiple layers of the disease: releasing the exterior, clearing interior heat, transforming dampness, and protecting the Spleen. Rather than building herb by herb, this formula assembles four proven classical formulas into one coordinated prescription, allowing them to work together at the formula level to expel pathogenic factors quickly and from multiple organ systems at once.

King herbs

Ma Huang and Chai Hu serve as the twin Kings of this formula. Ma Huang opens the Lung Qi and releases the exterior, directly addressing the Cold pathogen that has closed down the Lung's dispersing function, causing cough, wheezing, and nasal congestion. Chai Hu, at the highest dose in the formula (16g), harmonizes the Shaoyang level, intercepting the pathogen as it attempts to transmit deeper into the body. Together they establish a two-front defense: Ma Huang pushes the pathogen outward through the skin, while Chai Hu vents it from the half-exterior, half-interior Shaoyang layer.

Deputy herbs

Sheng Shi Gao provides the essential heat-clearing counterbalance: as the pathogenic Cold transforms into Heat inside the body (a common progression in epidemic disease), Shi Gao clears Lung-level and Yangming heat, preventing the warm, dispersing herbs from generating excessive internal heat. Xing Ren descends Lung Qi to stop cough and pairs with Ma Huang to restore the normal ascending-descending rhythm of the Lungs. Gui Zhi warms the channels and promotes Yang Qi circulation, assisting both exterior release and Bladder Qi transformation for water metabolism. Huang Qin clears Shaoyang heat and pairs with Chai Hu in the classical Xiao Chai Hu Tang dynamic of venting and clearing.

Assistant herbs

Reinforcing assistants: Fu Ling, Ze Xie, Zhu Ling, and Bai Zhu form the Wu Ling San core, draining accumulated dampness through urination while strengthening the Spleen's capacity to transport fluids. This addresses the fundamental damp component of the disease that manifests as fatigue, heavy limbs, chest oppression, and loose stools. She Gan, Zi Wan, Kuan Dong Hua, and Xi Xin constitute the She Gan Ma Huang Tang component, specifically targeting phlegm-obstruction in the throat and airways, warming Cold-Thin-Mucus in the Lungs, and relieving cough.

Restraining assistants: Shan Yao gently tonifies Spleen and Lung Qi and nourishes Yin, preventing the strongly dispersing and draining herbs from depleting the body's righteous Qi. Sheng Jiang warms the Stomach to moderate the cold nature of Shi Gao and support digestion during illness.

Secondary support: Huo Xiang aromatically transforms turbid dampness, addressing the damp-toxic quality of the epidemic pathogen at a level that the bland-percolating diuretics cannot reach. Chen Pi and Zhi Shi regulate Qi flow in the Middle Burner and break through stagnation, ensuring that accumulated phlegm-dampness can move and be expelled. Jiang Ban Xia dries dampness, dissolves phlegm, and descends Stomach Qi to stop nausea.

Envoy herbs

Zhi Gan Cao (honey-prepared Licorice) harmonizes the entire prescription, buffering the harsh properties of the strongly moving and draining herbs, protecting the Stomach, and tonifying Spleen Qi. It serves as the glue that unifies four separate classical formulas into a single cohesive prescription, moderating potential conflicts between warming herbs (Ma Huang, Gui Zhi, Xi Xin) and cooling herbs (Shi Gao, Huang Qin). The recommended rice congee taken after the decoction further protects the Stomach and generates fluids.

Notable synergies

Ma Huang + Shi Gao: This is the core pairing of Ma Xing Shi Gan Tang. Ma Huang opens the Lung while Shi Gao clears heat. Together they address the common clinical reality of simultaneous exterior Cold and interior Heat. Chai Hu + Huang Qin: The pivotal Shaoyang pair from Xiao Chai Hu Tang. Chai Hu vents the pathogen outward while Huang Qin clears heat inward, preventing deeper transmission. Zi Wan + Kuan Dong Hua: A classical cough-relief pair that descends Lung Qi, moistens dryness, and dissolves phlegm from complementary angles. Ma Huang + Xi Xin + Gui Zhi: A warming triad that penetrates deeply lodged Cold-Damp and restores Yang Qi circulation, essential for the Cold-Damp Pestilence pathomechanism.

How to Prepare

Traditional preparation instructions for Qing Fei Pai Du Tang

Use traditional Chinese herbal decoction pieces (饮片). Add the full day's herbs to an appropriate amount of water. Sheng Shi Gao (raw Gypsum) must be decocted first for 30 minutes before adding the remaining herbs.

Bring to a boil, then simmer for approximately 30-40 minutes. Strain and divide the decoction into two equal portions. Take one portion in the morning and one in the evening, both after meals (approximately 40 minutes after eating), served warm.

One package constitutes one daily dose. Three doses (three days) make up one course of treatment. After taking the medicine, it is recommended to drink half a bowl of plain rice congee (大米汤). Patients with dry mouth or depleted fluids may drink up to a full bowl of congee. If symptoms improve but have not fully resolved after the first course, continue with a second course. The second course may be modified according to the individual clinical situation. Discontinue once symptoms have resolved. Do not combine with other medicines (including Chinese patent medicines) during treatment.

Common Modifications

How practitioners adapt Qing Fei Pai Du Tang for specific situations

Added
Shi Gao

Increase dosage to 30-45g to strengthen heat-clearing action

When fever is high or persistent, Shi Gao dosage is increased to match the severity of the interior Heat. The original formula already specifies 15-30g as a flexible range, and in cases of strong heat, going to the higher end or slightly beyond is indicated.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Qing Fei Pai Du Tang should not be used or requires extra caution

Avoid

Pregnancy. The formula contains Ma Huang (Ephedra), Xi Xin (Asarum), and Ban Xia (Pinellia), all of which carry documented pregnancy risks including uterine stimulation and potential teratogenicity. Chinese health authorities explicitly exclude pregnant women from the recommended user population.

Avoid

Children under 6 years of age. Official Chinese guidelines state that this formula is not suitable for children under 6, as dosage safety data for this age group are lacking.

Avoid

Known allergy or hypersensitivity to any ingredient in the formula. Allergic reactions including skin rash have been reported. If any adverse reaction occurs (rash, vomiting, diarrhea), the formula should be stopped immediately.

Caution

Severe cardiac arrhythmia, tachycardia, or serious heart disease. Ma Huang (Ephedra) contains sympathomimetic alkaloids that can increase heart rate and blood pressure. Use requires careful medical supervision in cardiac patients.

Caution

Severe liver or kidney impairment. Patients with significant hepatic or renal dysfunction should only use this formula under close medical supervision due to altered drug metabolism and potential toxicity concerns.

Caution

Elderly patients and those with chronic underlying conditions (diabetes, hypertension). Dosage adjustment and professional supervision are required. These populations may be more susceptible to the stimulant effects of Ma Huang or the fluid-draining effects of the diuretic herbs.

Caution

Pure Yin-deficiency Heat patterns without any exterior pathogenic involvement. The formula's dispersing and drying herbs (Ma Huang, Xi Xin, Ban Xia) can further injure Yin fluids when no external pathogen is present, worsening dryness and internal Heat.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated. Chinese health authorities explicitly state that pregnant women are not within the recommended user population for Qing Fei Pai Du Tang. The formula contains several herbs with known pregnancy risks: - Ma Huang (Ephedra): contains sympathomimetic alkaloids that can raise blood pressure and heart rate, and may stimulate uterine contractions. - Xi Xin (Asarum): classified as a restricted or banned substance in some jurisdictions due to aristolochic acid content, and traditionally considered incompatible with pregnancy. - Jiang Ban Xia (prepared Pinellia): despite ginger processing to reduce toxicity, Pinellia is classically listed among pregnancy-cautioned herbs. - Zhi Shi (Immature Bitter Orange): has Qi-moving and downward-directing properties that may theoretically affect the uterus. Pregnant women who develop respiratory illness should consult their healthcare provider for individually tailored treatment.

Breastfeeding

Caution advised. Chinese health guidelines recommend that breastfeeding women use this formula only under the guidance of a qualified physician. While specific data on transfer of the formula's active compounds through breast milk are limited, several ingredients raise concerns: - Ma Huang (Ephedra): ephedrine alkaloids are known to pass into breast milk and may cause irritability, sleep disturbance, or tachycardia in the nursing infant. - Xi Xin (Asarum): contains potentially toxic aristolochic acid derivatives, and its safety profile during lactation is unknown. - Jiang Ban Xia (Pinellia): while processed to reduce toxicity, its effects on breastfed infants have not been studied. If treatment is necessary, a practitioner may consider modifications or substitutions. Short-term use (one course of 3 days) under medical supervision is more acceptable than prolonged use.

Children

Official Chinese guidelines exclude children under 6 years of age from the recommended population for Qing Fei Pai Du Tang. For children aged 6 and above, the formula should only be used under the direct supervision of a qualified TCM practitioner, with dosages adjusted proportionally based on age and body weight. A common guideline is: - Ages 6-9: approximately 1/3 to 1/2 of the adult dose - Ages 10-14: approximately 1/2 to 2/3 of the adult dose - Ages 15+: may approach adult dosing depending on body size Special attention should be paid to Ma Huang (Ephedra), which can cause restlessness, insomnia, and elevated heart rate in children, and Xi Xin (Asarum), which is restricted in several jurisdictions due to safety concerns. If the child shows any adverse reactions such as vomiting, diarrhea, palpitations, or skin rash, the formula must be discontinued immediately. For very young children with respiratory illness, practitioners typically prefer gentler pediatric-specific formulas.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Qing Fei Pai Du Tang

Gan Cao (Licorice root) in this formula is known to interact with several drug classes. Glycyrrhizin, its active compound, can cause pseudoaldosteronism (potassium loss and sodium retention), potentially worsening the effects of: (1) antihypertensives by counteracting blood pressure lowering; (2) diuretics (especially potassium-wasting types like furosemide or hydrochlorothiazide), compounding potassium depletion; (3) cardiac glycosides (digoxin), where hypokalemia increases the risk of cardiac toxicity; and (4) corticosteroids, enhancing their side effects through additive mineralocorticoid activity. Additionally, per the classical "eighteen incompatibilities" (十八反), Gan Cao should not be combined with prescriptions containing Gan Sui, Jing Da Ji, Hai Zao, or Yuan Hua.

Ma Huang (Ephedra) contains ephedrine and pseudoephedrine, which are sympathomimetic amines. It should not be combined with: (1) MAO inhibitors, due to the risk of hypertensive crisis; (2) other sympathomimetics or stimulants (including caffeine, decongestants), due to additive cardiovascular stimulation; (3) beta-blockers, which may cause paradoxical hypertension when combined with ephedrine; (4) cardiac glycosides (digoxin), as ephedrine-induced arrhythmia risk is increased.

Sheng Shi Gao (Gypsum) contains calcium ions, which may reduce the absorption of tetracycline antibiotics, fluoroquinolones, and bisphosphonates through chelation if taken concurrently.

Huang Qin (Scutellaria) contains baicalin, which may inhibit certain cytochrome P450 enzymes and could theoretically affect the metabolism of drugs processed through these pathways, though clinical significance is not fully established.

The National Administration of Traditional Chinese Medicine has also advised that during the first course of treatment, Qing Fei Pai Du Tang should not be taken simultaneously with other medications, including other Chinese patent medicines, to ensure the formula's therapeutic integrity.

Usage Guidance

Practical advice for getting the most out of Qing Fei Pai Du Tang

Best time to take

Twice daily (morning and evening), 40 minutes after meals, served warm. Optionally follow each dose with a small bowl of warm rice porridge.

Typical duration

Acute use: 3 days per course (one dose daily). A second course may follow with possible modifications based on the patient's response. Not intended for long-term use.

Dietary advice

While taking Qing Fei Pai Du Tang, avoid cold and raw foods (salads, ice cream, cold drinks, raw fruit), greasy and fried foods, dairy products, and overly sweet or rich foods. These can generate more Dampness and Phlegm internally, counteracting the formula's drying and transforming actions. Avoid alcohol, strong tea, and coffee, which can interfere with the herbs' actions. Favor warm, easily digestible foods: plain rice porridge (congee), steamed vegetables, light soups. The official dosing instructions specifically recommend drinking a small bowl of warm rice porridge (大米汤) after taking each dose to support the Stomach Qi and help the formula's ingredients distribute throughout the body. Avoid sour and astringent foods (vinegar, citrus, pickled foods) during treatment, as these can counteract the dispersing actions of the exterior-releasing herbs.

Qing Fei Pai Du Tang originates from New formula created in January 2020 by Ge Youwen (葛又文), a special researcher at the China Academy of Chinese Medical Sciences, combining and modifying classical formulas from Zhang Zhongjing's Shang Han Za Bing Lun (伤寒杂病论). Officially recommended by the National Health Commission and National Administration of Traditional Chinese Medicine on February 6, 2020. Modern, 2020 CE (based on Hàn dynasty classical formulas, ~200 CE)

Classical Texts

Key passages from the classical Chinese medical texts that first described Qing Fei Pai Du Tang and its clinical use

Qing Fei Pai Du Tang is a modern formula (2020) and does not appear in any classical text. However, it is assembled from component formulas found in Zhang Zhongjing's Shang Han Za Bing Lun (Treatise on Cold Damage and Miscellaneous Diseases, c. 220 CE). The classical principles underlying its construction include:

Ma Xing Shi Gan Tang — from the Shang Han Lun:
Original text: 「发汗后,不可更行桂枝汤,汗出而喘,无大热者,可与麻黄杏仁甘草石膏汤。」
Translation: "After inducing sweating, if Gui Zhi Tang should no longer be used, and there is sweating with wheezing but no great [external] fever, Ma Huang Xing Ren Gan Cao Shi Gao Tang may be given."

Xiao Chai Hu Tang — from the Shang Han Lun:
Original text: 「伤寒五六日中风,往来寒热,胸胁苦满,嘿嘿不欲饮食,心烦喜呕...小柴胡汤主之。」
Translation: "Cold Damage of five or six days, or Wind-strike, with alternating chills and fever, fullness and discomfort in the chest and flanks, silence and no desire to eat, vexation and tendency to vomit... Xiao Chai Hu Tang governs this."

Wu Ling San — from the Shang Han Lun:
Original text: 「太阳病,发汗后...脉浮,小便不利,微热消渴者,五苓散主之。」
Translation: "In Tai Yang disease, after sweating... if the pulse is floating, urination is difficult, and there is mild fever with thirst, Wu Ling San governs this."

Historical Context

How Qing Fei Pai Du Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Qing Fei Pai Du Tang is not a classical formula but rather a modern creation developed in January 2020 during the COVID-19 pandemic. It was formulated by Ge Youwen (葛又文), a specially appointed researcher at the China Academy of Chinese Medical Sciences, at the urgent request of the National Administration of Traditional Chinese Medicine. On January 20, 2020, the administration contacted Ge to devise a formula targeting the core pathomechanism of the emerging epidemic.

Ge's innovative approach was to combine not individual herbs but entire classical prescriptions as building blocks. He drew from four (some analyses identify five) classical formulas from Zhang Zhongjing's Shang Han Za Bing Lun (c. 220 CE): Ma Xing Shi Gan Tang, She Gan Ma Huang Tang (minus Wu Wei Zi and Da Zao), Xiao Chai Hu Tang (minus Ren Shen and Da Zao), and Wu Ling San, with the additional strategy elements of Ju Zhi Jiang Tang (Orange Peel, Immature Bitter Orange, and Ginger Decoction). To these he added Shan Yao and Huo Xiang. Clinical observation began on January 27, 2020, across four provinces (Shanxi, Hebei, Heilongjiang, Shaanxi). Within six days, results were promising enough for the formula to be recommended nationally. By February 2020, it was officially recommended by China's National Health Commission and was included from the 6th edition onward in the national COVID-19 diagnosis and treatment guidelines as a universal formula for mild, moderate, severe, and critical cases.

The formula became the most widely used herbal prescription during the pandemic in China, deployed across 28 provinces with over 390,000 doses supplied in Wuhan alone. In March 2021, the National Medical Products Administration granted it the first "Classical Formula-derived" drug approval number (国药准字C20210001), and in January 2023 it was successfully included in China's national medical insurance drug catalog. Its cultural significance extends beyond clinical medicine: it became a symbol of TCM's role in public health emergency response and renewed interest in the Shang Han Lun tradition of epidemic disease management.

Modern Research

5 published studies investigating the pharmacological effects or clinical outcomes of Qing Fei Pai Du Tang

1

Association between Use of Qingfei Paidu Tang and Mortality in Hospitalized Patients with COVID-19: A National Retrospective Registry Study (2021)

Zhang L, Zheng X, Bai X, et al. Phytomedicine, 2021, 85, 153531.

A large retrospective study using a national registry of 8,939 hospitalized COVID-19 patients in 15 hospitals in China (January to May 2020). About 28.7% of patients received Qingfei Paidu Tang. Using propensity score analysis, the study found that QPT use was associated with significantly lower in-hospital mortality compared to non-use, after adjusting for patient characteristics and disease severity.

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2

Effectiveness and Safety Research of Qingfei Paidu (QFPD) in Treatment of COVID-19: An Up-to-Date Systematic Review and Meta-Analysis (2022)

Wang X, Ma T, Zhang W, Chu Q. Chinese Medicine, 2022, 17(1), 122.

A systematic review and meta-analysis searching seven databases up to September 2022. Using the Cochrane Risk of Bias tool, the study pooled data on clinical cure rate, lung CT improvement, hospital stay duration, nucleic acid conversion time, and symptom resolution. Results supported the clinical effectiveness and safety of QFPD as a treatment for COVID-19.

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3

Effect of Qingfei Paidu Decoction Combined with Western Medicine Treatments for COVID-19: A Systematic Review and Meta-Analysis (2022)

Zhang L, Ma Y, Shi N, et al. Phytomedicine, 2022, 102, 154166.

A systematic review and meta-analysis of 9 controlled trials including 1,108 COVID-19 patients, examining the combination of QFPD with standard Western medical treatment. Pooled results indicated that the combination group showed improved clinical effective rates, shortened viral shedding duration, and reduced hospital stay length compared to Western medicine alone.

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4

Efficacy and Safety of Qingfei Paidu Decoction for Treating COVID-19: A Systematic Review and Meta-Analysis (2021)

Wang Q, Zhu H, Li M, et al. Frontiers in Pharmacology, 2021, 12, 688857.

A systematic review searching seven databases up to March 2021, evaluating clinical efficacy and safety of QFPD using Cochrane Risk of Bias, Newcastle-Ottawa Scale, and GRADE assessment. The analysis included multiple study designs and found favorable outcomes for QFPD-treated patients across multiple endpoints including symptom resolution and imaging improvement.

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5

Systems Pharmacological Study Illustrates the Immune Regulation, Anti-infection, Anti-inflammation, and Multi-Organ Protection Mechanism of Qing-Fei-Pai-Du Decoction in the Treatment of COVID-19 (2020)

Zhao J, Tian S, Lu D, et al. Phytomedicine, 2021, 85, 153315.

A network pharmacology study identifying 163 active ingredients from the formula's 21 herbs and mapping their targets to COVID-19-related pathways. The study showed that the formula's compounds target ACE2, inflammatory cytokine pathways, and apoptosis signaling, suggesting multi-target anti-viral, anti-inflammatory, and immune-regulatory mechanisms.

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Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.