Xuan Fei Bai Du Fang

Ventilate the Lungs and Overcome Toxin Formula · 宣肺败毒方

Also known as: Xuanfei Baidu Formula, Xuanfei Baidu Tang, XFBD,

A modern formula developed during the COVID-19 pandemic to treat respiratory infections caused by dampness and toxins obstructing the Lungs. It opens the airways, resolves dampness, clears heat, and expels toxins, helping relieve fever, cough, shortness of breath, fatigue, and poor appetite. It was one of China's key "Three Prescriptions" used to prevent mild respiratory illness from progressing to severe disease.

Origin Developed by Zhang Boli (张伯礼) and Liu Qingquan (刘清泉) during the COVID-19 pandemic, 2020. Derived from five classical formulas: Ma Xing Shi Gan Tang (Shang Han Lun), Ma Xing Yi Gan Tang (Jin Gui Yao Lue), Ting Li Da Zao Xie Fei Tang (Jin Gui Yao Lue), Wei Jing Tang (Wai Tai Mi Yao), and Bu Huan Jin Zheng Qi San (Tai Ping Hui Min He Ji Ju Fang). — Modern era, 2020 CE (developed during COVID-19 pandemic in Wuhan)
Composition 13 herbs
Ma Huang
King
Ma Huang
Shi Gao
King
Shi Gao
Cang Zhu
Deputy
Cang Zhu
Huo Xiang
Deputy
Huo Xiang
Qing Hao
Deputy
Qing Hao
Hu Zhang
Deputy
Hu Zhang
Ma Bian Cao
Deputy
Ma Bian Cao
Yi Yi Ren
Deputy
Yi Yi Ren
+5
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Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Xuan Fei Bai Du Fang is designed to correct these specific patterns.

Why Xuan Fei Bai Du Fang addresses this pattern

This is the primary pattern the formula was designed for. When epidemic damp-toxin (湿毒疫邪) lodges in the Lungs, it blocks the Lung's dispersing and descending functions, creating a syndrome of fever, cough, chest tightness, shortness of breath, and fatigue. The dampness component manifests as a greasy tongue coating, poor appetite, and sluggish bowels, while the heat-toxin component shows as a dark red tongue body, yellow coating, and slippery-rapid pulse. The formula directly addresses this pattern on multiple fronts: Ma Huang and Shi Gao ventilate the Lungs and clear heat; Cang Zhu, Huo Xiang, and Qing Hao aromatically transform dampness; Hu Zhang and Ma Bian Cao resolve toxins and prevent blood stasis; and Yi Yi Ren, Lu Gen, and Ting Li Zi drain dampness and congestion downward. The overall effect is to restore the Lung's normal function by clearing the damp-toxin obstruction from above, below, and within.

A practitioner would look for one or more of these signs

Fever

Fever that may fluctuate, not fully resolving

Shortness Of Breath

Chest tightness and shortness of breath

Sore Throat

Throat discomfort

Eye Fatigue

Pronounced fatigue and weakness

Poor Appetite

Poor appetite (纳呆)

Constipation

Sluggish, incomplete bowel movements

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Xuan Fei Bai Du Fang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Damp-Toxin obstructing the Lungs

TCM Interpretation

TCM physicians who treated COVID-19 patients in Wuhan identified the core disease character as "damp-toxin epidemic" (湿毒疫). Unlike a purely Wind-Heat invasion, this epidemic pathogen carries a heavy dampness component that obstructs the middle and upper burners, clogs the Lungs, and tends to progress from the Qi level into the Blood level if unchecked. The dampness creates symptoms like fatigue, poor appetite, heavy limbs, and sluggish bowels, while the toxin-heat produces fever, sore throat, and a dark red tongue. The Lungs are the primary target organ. When damp-toxin blocks the Lung's dispersing and descending functions, cough, chest tightness, and labored breathing follow. In more serious progression, the damp-toxin can congeal with blood to form stasis, damaging the lung's vascular network.

Why Xuan Fei Bai Du Fang Helps

Xuan Fei Bai Du Fang was specifically designed for this illness pattern. Ma Huang and Shi Gao (from Ma Xing Shi Gan Tang) ventilate the Lungs and clear heat to restore breathing. Cang Zhu and Huo Xiang (from Bu Huan Jin Zheng Qi San) aromatically transform the dampness that characterizes this epidemic. Hu Zhang and Ma Bian Cao were added based on modern pharmacological screening showing strong antiviral and anti-microthrombotic activity, while in TCM terms they resolve toxins and invigorate blood to prevent the damp-toxin-to-stasis progression. Yi Yi Ren, Lu Gen, and Ting Li Zi (drawing from Wei Jing Tang and Ting Li Da Zao Xie Fei Tang) drain Lung congestion downward and promote the elimination of damp-heat through the intestines and urinary tract. Clinical observation of 564 patients at the Jiangxia shelter hospital showed zero progression from mild to severe disease when this formula was used.

Also commonly used for

Acute Bronchitis

With fever, cough, and damp-heat signs

Influenza

With predominant dampness and Lung obstruction

Upper Respiratory Tract Infections

With fever, cough, and damp-heat presentation

Acute Lung Injury

Early stage, with inflammatory damp-heat pattern

What This Formula Does

Every TCM formula has a specific set of actions — here's what Xuan Fei Bai Du Fang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Xuan Fei Bai Du Fang is primarily used to support these areas of health:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Xuan Fei Bai Du Fang works at the root level.

Xuan Fei Bai Du Fang addresses a pattern called "Damp-Toxin obstructing the Lungs" (湿毒郁肺证). In TCM understanding, this is what happens when a toxic epidemic pathogen with a strong Dampness component invades the body. The pathogen enters through the nose and mouth, lodging first in the Lungs. At the same time, because Dampness is heavy and sticky by nature, it also bogs down the Spleen's ability to transport and transform fluids. This creates a vicious cycle: the Spleen can no longer move fluids upward properly, so excess moisture accumulates in the Lungs, while the toxic Heat from the pathogen itself generates inflammation and congestion in the respiratory tract.

The result is a characteristic mix of symptoms. The person develops fever, cough (often with scant or yellowish phlegm), tightness and shortness of breath, fatigue, poor appetite, and sluggish bowels. The tongue appears dark red with a swollen body and a yellow, greasy coating, reflecting the entanglement of Heat and Dampness. The pulse is slippery-rapid or wiry-slippery, indicating that the pathogen is both Hot and Damp in character. Because the Lungs' natural dispersing and descending functions are blocked by this Damp-Toxin combination, Qi stagnates in the chest, producing the hallmark sensation of chest oppression and labored breathing.

The formula works by addressing both sides of this pathology simultaneously. It reopens the Lungs' ability to disperse and descend ("diffusing" the Lungs), clears the toxic Heat, and resolves the Dampness that has clogged both the Lungs and the digestive system. This dual approach, targeting both the upper respiratory obstruction and the underlying Dampness in the middle, is what makes it suited to this particular pattern of epidemic illness.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly acrid and bitter with a sweet undertone. Acrid to open and disperse the Lungs, bitter to drain Heat and Dampness downward, sweet to harmonize and protect the Stomach.

Ingredients

13 herbs

The herbs that make up Xuan Fei Bai Du Fang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Ma Huang

Ma Huang

Ephedra

Dosage 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Urinary Bladder, Lungs

Role in Xuan Fei Bai Du Fang

Acrid and warm, Ma Huang ventilates Lung Qi and promotes sweating to release exterior pathogens. It opens the Lungs to relieve wheezing and is the primary herb for restoring the Lung's dispersing function when it is obstructed by damp-toxins.
Shi Gao

Shi Gao

Gypsum

Dosage 30g
Temperature Cold
Taste Pungent, Sweet
Organ Affinity Lungs, Stomach
Preparation Decocted first for 15-20 minutes (先煎), crushed before decocting

Role in Xuan Fei Bai Du Fang

Acrid and cold, Shi Gao powerfully clears Lung heat and disperses pathogenic heat outward. Paired with Ma Huang, it ensures the formula ventilates the Lungs and clears heat simultaneously, preventing the warm nature of Ma Huang from worsening internal heat.
Deputies — Assists and enhances the King
Cang Zhu

Cang Zhu

Black atractylodes rhizomes

Dosage 10g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Spleen, Stomach

Role in Xuan Fei Bai Du Fang

Aromatic and bitter-warm, bran-fried Cang Zhu dries dampness, strengthens the Spleen, and dispels turbidity. It addresses the core dampness component of the pathomechanism, working with Huo Xiang to transform dampness from the middle burner and restore the Spleen's transportation function.
Huo Xiang

Huo Xiang

Korean mint

Dosage 15g
Temperature Warm
Taste Pungent
Organ Affinity Lungs, Spleen, Stomach

Role in Xuan Fei Bai Du Fang

Aromatic and acrid-warm, Huo Xiang transforms dampness, harmonizes the middle burner, and dispels turbid pathogens. Combined with Cang Zhu, it provides aromatic dampness-transforming power to support the Lung's dispersing function from below.
Qing Hao

Qing Hao

Sweet wormwood herbs

Dosage 12g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Kidneys, Liver

Role in Xuan Fei Bai Du Fang

Bitter, acrid, and cold with an aromatic quality, Qing Hao clears heat from the blood level and disperses lurking heat outward. It enhances Shi Gao's heat-clearing action and balances the warm-drying nature of Cang Zhu and Huo Xiang, preventing them from becoming excessively warming.
Hu Zhang

Hu Zhang

Bushy knotweed rhizomes

Dosage 20g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Liver, Lungs

Role in Xuan Fei Bai Du Fang

Bitter and slightly cold, Hu Zhang resolves toxins, invigorates blood, and transforms phlegm. Modern research identified its active compound (polydatin) as having strong antiviral activity against coronaviruses. It prevents damp-toxins from congealing into blood stasis.
Ma Bian Cao

Ma Bian Cao

Verbena leaves

Dosage 30g
Temperature Cool
Taste Bitter
Organ Affinity Spleen, Liver

Role in Xuan Fei Bai Du Fang

Bitter and cool, Ma Bian Cao clears heat, resolves toxins, and invigorates blood to free the collaterals. Research showed it has strong activity against small-airway damage and microthrombosis caused by viral lung injury. Paired with Hu Zhang, it ensures toxins are expelled and the lung's vascular network remains open.
Yi Yi Ren

Yi Yi Ren

Job's tears

Dosage 30g
Temperature Cool
Taste Sweet
Organ Affinity Lungs, Spleen, Stomach

Role in Xuan Fei Bai Du Fang

Sweet, bland, and slightly cold, Yi Yi Ren clears Lung heat, drains dampness downward, and supports the Spleen. It works with Lu Gen and Ting Li Zi to clear congestion from the Lungs and drain turbid fluids via the lower route.
Lu Gen

Lu Gen

Common reed rhizomes

Dosage 30g
Temperature Cold
Taste Sweet
Organ Affinity Lungs, Stomach

Role in Xuan Fei Bai Du Fang

Sweet and cold with a light, ascending nature, Lu Gen clears Lung heat, generates fluids, and promotes the expulsion of phlegm. It helps vent pathogenic heat outward from the Lungs.
Ting Li Zi

Ting Li Zi

Lepidium seeds

Dosage 15g
Temperature Cold
Taste Bitter, Pungent
Organ Affinity Urinary Bladder, Lungs

Role in Xuan Fei Bai Du Fang

Bitter, acrid, and very cold, Ting Li Zi powerfully drains the Lungs, reduces phlegm congestion, and relieves wheezing. It directs Lung Qi downward and promotes bowel movement, helping expel damp-heat toxins through the lower route.
Assistants — Supports or moderates other herbs
Xing Ren

Xing Ren

Apricot seeds

Dosage 15g
Temperature Warm
Taste Bitter, Sweet
Organ Affinity Large Intestine, Lungs
Preparation Blanched (燀) to reduce toxicity

Role in Xuan Fei Bai Du Fang

Bitter and slightly warm, Ku Xing Ren descends Lung Qi to relieve coughing and wheezing. Paired with Ma Huang, it creates the classic combination of one dispersing and one descending herb to restore normal Lung Qi circulation.
Ju Hong

Ju Hong

Red Tangerine Peel

Dosage 15g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Spleen, Lungs

Role in Xuan Fei Bai Du Fang

Acrid, bitter, and slightly warm, Hua Ju Hong dries dampness, moves Qi, and transforms phlegm in the middle burner. It supports Cang Zhu and Huo Xiang in restoring proper Qi circulation, helping the Spleen transport and transform fluids.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Liquorice

Dosage 10g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Xuan Fei Bai Du Fang

Sweet and slightly cool, raw Gan Cao harmonizes all herbs in the formula, moderates the harshness of the cold-natured and bitter herbs, resolves toxins, and soothes cough. It serves as both harmonizing envoy and gentle detoxifier.

Why This Combination Works

How the herbs in Xuan Fei Bai Du Fang complement each other

Overall strategy

The core pathomechanism is damp-toxin (湿毒) obstructing the Lungs, with heat building internally and the Lung's dispersing and descending functions impaired. The formula addresses this through a multi-layered strategy: ventilating the Lungs from above, draining dampness and phlegm downward, clearing heat and resolving toxins, and invigorating blood to prevent stasis from forming as the illness progresses.

King herbs

Ma Huang (6g) and Shi Gao (30g) form the King pair, adapted from the classical Ma Xing Shi Gan Tang combination. Ma Huang, though used in a relatively small dose, is essential for restoring the Lung's ability to disperse Qi outward, open the airways, and push pathogens to the surface. Shi Gao, at five times the dose, counterbalances Ma Huang's warmth and powerfully clears the heat trapped in the Lungs. Together, they open the Lung, relieve wheezing, and clear heat while guiding damp-toxins outward.

Deputy herbs

The Deputies form three functional clusters. First, the aromatic dampness-transforming group: Cang Zhu (bran-fried), Huo Xiang, and Qing Hao work together to dispel turbid dampness from the middle burner with their aromatic qualities, while Qing Hao adds a cooling, dispersing force that prevents the warm aromatics from generating excess dryness. Second, the toxin-resolving and blood-moving pair: Hu Zhang and Ma Bian Cao were selected based on both classical TCM principles and modern pharmacological screening. They clear heat-toxins from the blood level and free the collateral vessels, intercepting the disease before damp-toxins congeal into stasis. Third, the Lung-draining group: Yi Yi Ren, Lu Gen, and Ting Li Zi clear heat and congestion from the Lungs through different routes. Yi Yi Ren drains damp-heat downward; Lu Gen clears Lung heat and promotes the outward venting of pathogens; Ting Li Zi powerfully purges Lung congestion downward, also promoting bowel movement to expel toxins.

Assistant herbs

Ku Xing Ren (reinforcing assistant) descends Lung Qi to stop coughing and wheezing, complementing Ma Huang's ascending, dispersing action to restore the Lung's normal up-and-down Qi flow. Hua Ju Hong (reinforcing assistant) moves Qi and dries dampness in the middle burner, supporting the aromatic Deputies in their dampness-transforming role and helping to prevent phlegm from re-accumulating.

Envoy herbs

Gan Cao (raw) harmonizes all the herbs in the formula, moderates the strongly cold and bitter medicinals, and adds a gentle detoxifying and cough-soothing effect. Its sweet flavor also protects the Stomach from the formula's predominantly bitter and cold composition.

Notable synergies

The Ma Huang and Shi Gao pairing (from Ma Xing Shi Gan Tang) is the formula's engine: one opens, the other clears, together they ventilate the Lungs without generating excess heat or excess cold. The Hu Zhang and Ma Bian Cao pairing is the formula's innovation: both resolve toxins and invigorate blood, but Hu Zhang emphasizes stopping cough and transforming phlegm while Ma Bian Cao specializes in freeing the collaterals, together preventing the damp-toxin-to-stasis progression that drives severe disease. The overall composition creates a dynamic of "acrid-opening above and bitter-draining below" (辛开苦降), ensuring pathogenic damp-heat-toxins are simultaneously dispersed outward and drained downward.

How to Prepare

Traditional preparation instructions for Xuan Fei Bai Du Fang

Traditional decoction (水煎服). Use one daily dose of the raw herbs. Add an appropriate amount of water and decoct. Take 200 mL per dose, twice daily (morning and evening), by mouth. The full course of treatment is typically 7 to 14 days or as directed by a practitioner.

The formula is also commercially available as a granule preparation (Xuan Fei Bai Du Ke Li, 宣肺败毒颗粒), dissolved in hot water, one sachet per dose, twice daily.

Common Modifications

How practitioners adapt Xuan Fei Bai Du Fang for specific situations

Added
Zhi Mu

12g, enhances heat-clearing alongside Shi Gao

Huang Qin

9g, clears Lung heat and dries dampness

When heat-toxin predominates over dampness, adding Zhi Mu intensifies Shi Gao's heat-clearing power while Huang Qin specifically targets Lung heat and has demonstrated anti-inflammatory effects.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Xuan Fei Bai Du Fang should not be used or requires extra caution

Caution

Liver-Kidney Yin deficiency patterns without Dampness-Heat. The formula's drying, dispersing, and cold-clearing nature can further damage Yin fluids in patients who already have Yin deficiency.

Caution

Liver or kidney functional impairment. The approved granule product label cautions that patients with compromised liver or kidney function should use the formula under medical guidance and monitor liver function during treatment.

Caution

Tachycardia (heart rate already elevated). Ma Huang (Ephedra) in the formula can stimulate the cardiovascular system and worsen rapid heartbeat.

Avoid

Pregnancy. The formula contains Ma Bian Cao (Verbena) which traditionally promotes blood circulation and breaks stasis, and Hu Zhang (Polygonum cuspidatum) which invigorates blood. Both carry risk of stimulating uterine activity.

Caution

Prolonged or excessive use beyond the acute phase. This is designed for short-term, acute-phase treatment. The official label warns against exceeding the recommended dosage or using the formula repeatedly over extended periods.

Avoid

Concurrent use with formulas containing Hai Zao (Sargassum), Da Ji (Euphorbia), Gan Sui (Kansui), or Yuan Hua (Daphne). Gan Cao (Licorice) in this formula is classically incompatible with these substances (the '18 Incompatibilities').

Caution

Patients with profuse loose stools or diarrhea exceeding 3 times daily should use with caution or discontinue, as several herbs in the formula promote downward drainage of fluids.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated in pregnancy. The formula contains Ma Bian Cao (Verbena officinalis), which is traditionally classified as a blood-moving herb that promotes menstruation and breaks stasis, posing a risk of stimulating uterine contractions. Hu Zhang (Polygonum cuspidatum) also invigorates blood circulation. Additionally, Ma Huang (Ephedra) has sympathomimetic effects that could affect uterine blood flow. Ting Li Zi (Descurainiae/Lepidii Semen) has a strong draining action. The combined effect of these herbs makes this formula unsuitable for pregnant women.

Breastfeeding

Use with caution during breastfeeding. Ma Huang (Ephedra) contains ephedrine and pseudoephedrine, which are known to pass into breast milk and may cause irritability, poor sleep, or tachycardia in nursing infants. Ku Xing Ren (Bitter Apricot Seed) contains amygdalin, which can release small amounts of hydrogen cyanide during metabolism, a potential concern for infants. The formula is designed for short-term acute use, which limits exposure, but breastfeeding mothers should consult a qualified practitioner and consider temporarily suspending nursing or pumping and discarding milk during the treatment course.

Children

No specific pediatric clinical trials have been published for this formula. In general, the formula may be used in children with appropriate dose reduction under professional guidance, but several considerations apply: - Ma Huang (Ephedra) requires particular caution in young children due to its sympathomimetic effects on heart rate and blood pressure. Dosage should be carefully titrated. - Ku Xing Ren (Bitter Apricot Seed) contains amygdalin and must be strictly dosed in children; overdose risk is higher in small body weight. - For children under 3 years, the formula is generally not recommended without specialist supervision. - Children aged 3-14 may receive approximately one-third to one-half the adult dose, adjusted by age and body weight. - The decoction form is preferred over granules for pediatric use, as it allows more precise dosage control. - Monitor closely for loose stools (the official label advises medical guidance if bowel movements exceed 3 per day).

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Xuan Fei Bai Du Fang

Ephedrine-containing herb (Ma Huang): Ma Huang contains ephedrine and pseudoephedrine, which can interact with MAO inhibitors (risk of hypertensive crisis), sympathomimetic drugs, beta-blockers, and cardiac glycosides. Patients taking antihypertensives may experience reduced efficacy. Those on theophylline or other bronchodilators may experience additive stimulant effects. Competitive athletes should note that ephedrine is a banned substance in sports testing.

Gan Cao (Licorice): Glycyrrhizin in licorice can cause pseudoaldosteronism (sodium retention, potassium loss) with prolonged use. It may interact with antihypertensive medications, corticosteroids (potentiating their effects), digoxin and other cardiac glycosides (hypokalemia increases toxicity risk), and potassium-depleting diuretics (additive potassium loss). It may also affect the metabolism of drugs processed by CYP3A4 enzymes.

Hu Zhang (Polygonum cuspidatum): Contains emodin and resveratrol. Emodin has a mild laxative effect and may potentiate the action of stimulant laxatives. Resveratrol may have antiplatelet activity, so caution is warranted when combining with anticoagulants (warfarin, heparin) or antiplatelet drugs (aspirin, clopidogrel).

Ku Xing Ren (Bitter Apricot Seed): Contains amygdalin, which releases small amounts of hydrogen cyanide during metabolism. While safe at therapeutic doses, concurrent use with other cyanogenic foods or supplements should be avoided.

Usage Guidance

Practical advice for getting the most out of Xuan Fei Bai Du Fang

Best time to take

Twice daily, 30 minutes after meals, warm. Typically taken as 200mL of decoction per dose (or one sachet of granules), morning and evening.

Typical duration

Acute use: 7-14 days, reassessed frequently. Not intended for long-term or preventive use.

Dietary advice

While taking this formula, avoid cold and raw foods (salads, iced drinks, raw fruit in excess), greasy or deep-fried foods, and rich dairy products. These can generate or worsen Dampness in the body, directly opposing the formula's therapeutic intent. Favor light, easily digestible, warm-cooked foods such as congee (rice porridge), steamed vegetables, and clear broths. Small, frequent meals are preferable to large heavy ones, as the Spleen is already taxed by Dampness. Drinking warm water throughout the day supports the formula's fluid-transforming action. Avoid alcohol, which generates Damp-Heat, and highly spiced food, which may aggravate Heat symptoms. Smoking should be strictly avoided as it directly damages the Lungs.

Xuan Fei Bai Du Fang originates from Developed by Zhang Boli (张伯礼) and Liu Qingquan (刘清泉) during the COVID-19 pandemic, 2020. Derived from five classical formulas: Ma Xing Shi Gan Tang (Shang Han Lun), Ma Xing Yi Gan Tang (Jin Gui Yao Lue), Ting Li Da Zao Xie Fei Tang (Jin Gui Yao Lue), Wei Jing Tang (Wai Tai Mi Yao), and Bu Huan Jin Zheng Qi San (Tai Ping Hui Min He Ji Ju Fang). Modern era, 2020 CE (developed during COVID-19 pandemic in Wuhan)

Classical Texts

Key passages from the classical Chinese medical texts that first described Xuan Fei Bai Du Fang and its clinical use

This formula does not originate from a single classical text. It was created in 2020 by Academician Zhang Boli (张伯礼) and Professor Liu Qingquan (刘清泉) during the COVID-19 pandemic in Wuhan. However, it is built upon the foundations of four classical prescriptions:

  • Ma Xing Shi Gan Tang (麻杏石甘汤) from the Shang Han Lun (伤寒论) by Zhang Zhongjing:
    「汗出而喘,无大热者,麻杏甘石汤主之。」
    "When there is sweating with wheezing and no great fever, Ma Xing Gan Shi Tang governs."
  • Ma Xing Yi Gan Tang (麻杏薏甘汤) from the Jin Gui Yao Lue (金匮要略) by Zhang Zhongjing:
    「病者一身尽疼,发热,日晡所剧者,名风湿…可与麻黄杏仁薏苡甘草汤。」
    "When the patient has generalized body pain and fever that worsens in the afternoon, this is called Wind-Dampness…Ma Huang, Xing Ren, Yi Yi Ren, Gan Cao Tang may be given."
  • Ting Li Da Zao Xie Fei Tang (葶苈大枣泻肺汤) from the Jin Gui Yao Lue:
    「肺痈,喘不得卧…葶苈大枣泻肺汤主之。」
    "For Lung abscess with wheezing and inability to lie down…Ting Li Da Zao Xie Fei Tang governs."
  • Qian Jin Wei Jing Tang (千金苇茎汤) from the Wai Tai Mi Yao (外台秘要), attributed to Sun Simiao's Qian Jin Yao Fang:
    This formula uses Lu Gen (Reed rhizome) and Yi Yi Ren to clear Lung Heat and drain Dampness in cases of Lung abscess with purulent sputum.

The clinical rationale was summarized by the formula's creators as targeting the core pathogenesis of COVID-19 characterized as "湿毒疫" (Damp-Toxin Pestilence), where Dampness and toxins obstruct the Lungs.

Historical Context

How Xuan Fei Bai Du Fang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Xuan Fei Bai Du Fang (宣肺败毒方, "Diffuse the Lungs and Defeat Toxins Formula") is a modern formula created during the early weeks of the COVID-19 pandemic in Wuhan, China in January-February 2020. It was developed by Academician Zhang Boli (张伯礼), president of Tianjin University of Traditional Chinese Medicine and a member of the Chinese Academy of Engineering, together with Professor Liu Qingquan (刘清泉), dean of Beijing Hospital of Traditional Chinese Medicine. They formulated it on the front lines of clinical treatment after conducting systematic investigation of the TCM symptom patterns (证候) presented by COVID-19 patients, concluding that the disease's core nature was "Damp-Toxin Pestilence" (湿毒疫).

The formula was constructed by combining and modifying four classical prescriptions: Ma Xing Shi Gan Tang and Ma Xing Yi Gan Tang (from Zhang Zhongjing's Han Dynasty works), Ting Li Da Zao Xie Fei Tang (also from the Jin Gui Yao Lue), and Qian Jin Wei Jing Tang (from the Wai Tai Mi Yao, attributed to Sun Simiao). To this classical backbone, the creators added herbs identified through modern pharmacological screening from the Chinese Medicine Component Library, notably Hu Zhang (Polygonum cuspidatum, whose constituent polydatin showed strong antiviral activity against coronaviruses) and Ma Bian Cao (Verbena, found to protect against small-airway damage and microthrombosis). This blending of classical prescription logic with modern data-driven drug screening was described by Zhang Boli as the hallmark of this formula.

In clinical use at Wuhan's Jiangxia Fangcang (field hospital), an observational study of 280 patients treated with Xuan Fei Bai Du Fang reported that none progressed from mild/moderate to severe disease. It became one of the celebrated "Three Prescriptions and Three Medicines" (三方三药) officially recommended in China's national COVID-19 treatment guidelines (from the 6th through 9th editions). The granule form (宣肺败毒颗粒) was approved by China's National Medical Products Administration on March 2, 2021, through a special emergency approval pathway, making it the first TCM product approved under the new category 3.2 of China's revised TCM registration regulations for formulas derived from classical prescriptions.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Xuan Fei Bai Du Fang

1

Pilot Randomized Clinical Trial of Xuanfei Baidu Decoction Combined with Conventional Drug for COVID-19 (2020)

Xiong WZ, Wang G, Du J, Ai W. Integrative Medicine Research, 2020, 9(3): 100489.

A small RCT of 42 COVID-19 patients at Wuhan Hospital of TCM. Patients receiving Xuanfei Baidu plus conventional medicine for one week showed significantly faster resolution of fever, cough, fatigue, and appetite loss compared to conventional medicine alone. White blood cell and lymphocyte counts also increased significantly in the treatment group.

2

Xuanfei Baidu Formula Alleviates Impaired Mitochondrial Dynamics and Activated NLRP3 Inflammasome (Preclinical, 2023)

Li Z, Pan H, Yang J, Chen D, Wang Y, Zhang H, Cheng Y. Phytomedicine, 2023, 108: 154545.

An in vivo/in vitro study demonstrating that XFBD attenuated LPS-induced acute lung injury in mice by recovering mitochondrial dynamics and reducing NLRP3 inflammasome activation through suppression of NF-kB and MAPK pathways, providing a mechanistic rationale for its clinical anti-inflammatory effects.

3

Discovery and Evaluation of Active Compounds from Xuanfei Baidu Formula Against COVID-19 via SARS-CoV-2 Mpro (Preclinical, 2023)

Zhang M, Liu L, Zhao Y, Cao Y, Zhu Y, Han L, Yang Q, Wang Y, Wang C, Zhang H, Wang Y, Zhang J. Chinese Medicine, 2023, 18(1): 94.

Researchers screened XFBD for inhibitors of the SARS-CoV-2 main protease (Mpro) using FRET assay, SPR, and ITC methods. Acteoside, a compound from Ma Bian Cao (Verbena), was identified as a potent natural Mpro inhibitor with confirmed antiviral activity against Omicron BA.1.1 and BA.2.3 variants in cell culture.

4

Xuanfei Baidu Formula Confers Protection Against Viral Pneumonia by Modulating CD8+ T Cell Proliferation via MAPK Signalling Pathway (Preclinical, 2025)

Liu T, Ding M, Chen R, Xu Y, Fang Q, Song P, Zhang T, He J, Wang Y, Shao R, Zhang J, Ma Q, Chen L, Zhang H. Phytomedicine, 2025, 143: 156711.

This study found that XFBD enhanced CD8+ T cell proliferation through the MAPK signaling pathway in models of viral pneumonia induced by both influenza A virus and SARS-CoV-2, helping to explain its immune-boosting clinical effects including the observed increase in lymphocyte counts in patients.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.