Hua Shi Bai Du Fang

Dampness-Resolving Toxin-Defeating Formula · 化湿败毒方

Also known as: Q-14, Huashi Baidu Granules (化湿败毒颗粒, the manufactured form), Huashi Baidu Decoction

A modern formula developed during the COVID-19 pandemic to address severe respiratory infections caused by dampness and toxic pathogens lodging in the Lungs. It combines herbs that open the Lungs and relieve wheezing, transform dampness in the digestive system, promote elimination of toxins through the bowels, and support the body's own resistance. Also known internationally as "Q-14" for its 14 herbal ingredients.

Origin Developed by Huang Luqi (黄璐琦) and the National TCM Medical Team (China Academy of Chinese Medical Sciences) during the COVID-19 pandemic in Wuhan, 2020. Included in the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Versions 6-9) issued by China's National Health Commission. — Modern, 2020 CE
Composition 14 herbs
Ma Huang
King
Ma Huang
Shi Gao
King
Shi Gao
Cang Zhu
Deputy
Cang Zhu
Huo Xiang
Deputy
Huo Xiang
Xing Ren
Deputy
Xing Ren
Hou Pu
Assistant
Hou Pu
Cao Guo
Assistant
Cao Guo
Ban Xia
Assistant
Ban Xia
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Hua Shi Bai Du Fang is designed to correct these specific patterns.

Why Hua Shi Bai Du Fang addresses this pattern

This is the primary pattern the formula was designed for. Epidemic dampness-toxin enters through the nose and mouth and lodges in the Lungs, simultaneously generating Heat and producing thick, sticky dampness-phlegm that obstructs the airways. The Lung's ability to govern Qi and respiration is severely impaired, leading to fever, cough, dyspnea, and chest tightness. The dampness component also disrupts the Spleen and Stomach (middle burner), causing nausea, poor appetite, and loose stools or constipation. As the condition worsens, Heat and toxins may enter the Blood, and the body's defensive Qi becomes depleted.

The formula addresses this through its three-burner approach: Ma Huang, Shi Gao, Xing Ren and Ting Li Zi clear and drain the Lungs in the upper burner; Cang Zhu, Huo Xiang, Hou Po, Cao Guo, Ban Xia and Fu Ling transform dampness in the middle burner; Da Huang purges Heat-toxin through the lower burner; while Huang Qi and Chi Shao support the body's Qi and Blood. This comprehensive strategy matches the multi-system involvement of epidemic dampness-toxin diseases.

A practitioner would look for one or more of these signs

Fever

Persistent or high fever that does not resolve easily

Hypochondrial Pain That Is Worse On Coughing And Breathing

Cough with sticky or blood-streaked sputum

Exertional Dyspnea

Difficulty breathing, wheezing, shortness of breath

Chest Stiffness

Fullness and oppression in the chest

Nausea

Nausea and poor appetite from dampness obstructing the Stomach

Eye Fatigue

Generalized weakness and exhaustion

Constipation

Inhibited bowel movements or constipation from Heat accumulation

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Hua Shi Bai Du Fang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Dampness-Toxin Obstructing the Lung Damp-Heat

TCM Interpretation

In TCM, COVID-19 is understood as an epidemic disease (疫病) caused by a specific virulent pathogen, a "dampness-toxin" that enters through the nose and mouth. The Wuhan outbreak was notable for its strong dampness character, reflected in the heavy, sticky nature of the lung pathology, the prominent digestive symptoms, and the prolonged, difficult recovery. TCM theory recognizes that the pathogen first attacks the Lung (which governs respiration and the body surface), then spreads to disrupt the Spleen and Stomach (middle burner), and in severe cases invades the Blood level and depletes the body's Qi. The disease involves all three burners simultaneously, which is why single-target approaches are considered insufficient.

Why Hua Shi Bai Du Fang Helps

Hua Shi Bai Du Fang was specifically designed for COVID-19 through clinical observation of patients at Wuhan's Jinyintan Hospital. Its three-burner architecture matches the multi-system nature of the disease: Ma Huang with Shi Gao and Xing Ren open the Lungs and clear respiratory Heat (upper burner); Cang Zhu, Huo Xiang, Hou Po, Cao Guo, Ban Xia, and Fu Ling transform the dampness causing digestive symptoms and the heavy, sticky lung pathology (middle burner); Ting Li Zi drains phlegm-fluid from the Lungs while Da Huang purges Heat-toxin through the bowels (lower burner); and Huang Qi with Chi Shao support immune function and address the blood-level involvement seen in severe cases. Clinical trials showed it significantly shortened the time to viral clearance and hospitalization, and improved lung imaging and clinical symptoms.

Also commonly used for

Acute Respiratory Distress Syndrome

Adjunctive use in severe respiratory failure with dampness-toxin pathomechanism

Influenza

Severe influenza with prominent dampness signs (nausea, heavy body, greasy tongue coating)

Acute Bronchitis

With features of dampness-heat in the Lung

Pneumonia

When the TCM presentation matches dampness-toxin obstructing the Lung

What This Formula Does

Every TCM formula has a specific set of actions — here's what Hua Shi Bai Du Fang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Hua Shi Bai Du Fang is primarily used to support these areas of health:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Hua Shi Bai Du Fang works at the root level.

Hua Shi Bai Du Fang addresses what TCM calls an epidemic Dampness-Toxin (疫毒夹湿) that enters the body through the mouth and nose and rapidly obstructs all three levels of the body's internal landscape (the "Three Burners" or San Jiao). This is not ordinary Dampness from diet or weather, but a virulent, pestilential pathogen that combines the sticky, heavy, obstructing nature of Dampness with the fierce, invasive quality of epidemic Toxin.

In the upper Jiao (Lungs and chest), the Damp-Toxin clogs the Lung's ability to descend and disperse, leading to cough, wheezing, chest tightness, and shortness of breath. In the middle Jiao (Spleen and Stomach), the pathogen blocks the Spleen's transforming and transporting function, producing symptoms like nausea, poor appetite, abdominal bloating, and a thick greasy tongue coating. In the lower Jiao, accumulated Heat and stagnant Blood obstruct circulation and waste elimination, causing constipation and further internal toxicity. At the same time, this aggressive pathogen damages the body's protective Qi and immune defenses, creating a vicious cycle where weakened defenses allow the pathogen to penetrate deeper.

The formula's strategy addresses all three layers simultaneously: ventilating the Lungs above, transforming Dampness in the middle, purging Heat and moving Blood below, while also supplementing Qi to shore up the body's weakened defenses. This "San Jiao Fen Zhi" (三焦分治, treating all three burners) approach reflects an understanding that epidemic pathogens do not confine themselves to a single organ system but attack the whole body systemically.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly acrid and bitter with a secondary bland note. The acrid quality opens, disperses, and ventilates; the bitter flavor dries Dampness and drains Heat downward; the bland note (from Fu Ling) promotes the leaching of Dampness through urination.

Channels Entered

Ingredients

14 herbs

The herbs that make up Hua Shi Bai Du Fang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Ma Huang

Ma Huang

Ephedra

Dosage 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Urinary Bladder, Lungs

Role in Hua Shi Bai Du Fang

Opens and disseminates Lung Qi, relieves wheezing, and promotes mild sweating to release exterior pathogens from the upper body. As one of the primary herbs addressing the Lung, it works to restore the Lung's ability to govern Qi and respiration.
Shi Gao

Shi Gao

Gypsum

Dosage 15g
Temperature Cold
Taste Pungent, Sweet
Organ Affinity Lungs, Stomach
Preparation Decocted first for 30 minutes (先煎)

Role in Hua Shi Bai Du Fang

Clears Heat from the Lung and Stomach, counters fever and inflammation in the respiratory system. Paired with Ma Huang, it prevents the warm, dispersing nature of Ma Huang from aggravating internal Heat, creating the classic Ma Xing Shi Gan Tang dynamic of clearing Lung Heat while opening the airways.
Deputies — Assists and enhances the King
Cang Zhu

Cang Zhu

Black atractylodes rhizomes

Dosage 15g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Spleen, Stomach

Role in Hua Shi Bai Du Fang

Strongly dries dampness and strengthens the Spleen's transport function. At 15g, this is one of the highest-dosed herbs in the formula, reflecting the central importance of resolving dampness in the middle burner, consistent with the formula's name and primary strategy.
Huo Xiang

Huo Xiang

Korean mint

Dosage 10g
Temperature Warm
Taste Pungent
Organ Affinity Lungs, Spleen, Stomach
Preparation Added in last 5 minutes (后下) to preserve its aromatic volatile oils

Role in Hua Shi Bai Du Fang

Aromatically transforms dampness and turbidity, harmonizes the middle burner, stops nausea and vomiting. As a key herb from the Huo Xiang Zheng Qi tradition, it revives the Spleen and Stomach's ability to process fluids, directly addressing the dampness that characterizes this pattern.
Xing Ren

Xing Ren

Apricot seeds

Dosage 9g
Temperature Warm
Taste Bitter, Sweet
Organ Affinity Large Intestine, Lungs

Role in Hua Shi Bai Du Fang

Descends Lung Qi and relieves coughing and wheezing. Paired with Ma Huang (which opens and lifts), Xing Ren descends, creating a balanced rhythm of ascending and descending that restores the Lung's normal function.
Assistants — Supports or moderates other herbs
Hou Pu

Hou Pu

Houpu Magnolia bark

Dosage 10g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Lungs, Spleen, Stomach

Role in Hua Shi Bai Du Fang

Moves Qi and transforms dampness, reduces abdominal distension and fullness. Derived from the Da Yuan Yin tradition, it helps break through the pathogenic dampness lodged in the membrane source (Mo Yuan) and middle burner.
Cao Guo

Cao Guo

Tsaoko fruits

Dosage 10g
Temperature Warm
Taste Pungent
Organ Affinity Spleen, Stomach

Role in Hua Shi Bai Du Fang

Dries dampness and disperses cold, cuts through turbid dampness lodged deep in the body. Also from the Da Yuan Yin lineage, its strongly aromatic and drying nature helps penetrate to the membrane source and expel entrenched pathogenic dampness.
Ban Xia

Ban Xia

Crow-dipper rhizomes

Dosage 9g
Temperature Warm
Taste Pungent
Organ Affinity Lungs, Spleen, Stomach

Role in Hua Shi Bai Du Fang

Dries dampness and transforms phlegm, descends rebellious Stomach Qi to stop nausea and vomiting. Works with Huo Xiang and Hou Po to resolve the dampness-phlegm complex that obstructs the middle burner and contributes to respiratory congestion.
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 15g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Hua Shi Bai Du Fang

Promotes urination to drain dampness downward, strengthens the Spleen to prevent further dampness production. Provides a downward drainage route for the dampness being transformed by the aromatic and drying herbs above.
Huang Qi

Huang Qi

Milkvetch roots

Dosage 10g
Temperature Warm
Taste Sweet
Organ Affinity Lungs, Spleen

Role in Hua Shi Bai Du Fang

Tonifies Qi and supports the body's defensive capacity. Drawn from the Huang Qi Chi Feng Tang and Yu Ping Feng San traditions, it ensures the body's own Qi is strong enough to fight the pathogen and recover, preventing the formula's strong pathogen-expelling herbs from further weakening an already compromised patient.
Ting Li Zi

Ting Li Zi

Lepidium seeds

Dosage 10g
Temperature Cold
Taste Bitter, Pungent
Organ Affinity Urinary Bladder, Lungs

Role in Hua Shi Bai Du Fang

Drains the Lungs and drives out phlegm-fluid accumulation, relieves wheezing caused by fluid retention in the chest. Derived from the Ting Li Da Zao Xie Fei Tang tradition, it provides strong downward drainage of pathological fluids from the Lung, addressing the severe congestion seen in respiratory infections.
Chi Shao

Chi Shao

Red peony roots

Dosage 10g
Temperature Cool
Taste Bitter
Organ Affinity Liver

Role in Hua Shi Bai Du Fang

Clears Heat from the Blood level and invigorates Blood circulation. Addresses the Blood stasis and Heat that develop as the infection progresses deeper, and works with Huang Qi in a pairing inspired by the Huang Qi Chi Feng Tang to both support Qi and move Blood.
Da Huang

Da Huang

Rhubarb

Dosage 5g
Temperature Cold
Taste Bitter
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium
Preparation Added in last 5 minutes (后下) to preserve its purgative effect

Role in Hua Shi Bai Du Fang

Purges Heat downward through the bowels, clears toxins, and invigorates Blood. Derived from the Cheng Qi Tang tradition, it provides a critical exit pathway for accumulated Heat and toxins, preventing them from overwhelming the body. Its purgative action also helps relieve the constipation common in this pattern.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Liquorice

Dosage 3g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Hua Shi Bai Du Fang

Harmonizes all the other herbs, protects the Stomach from the strong attacking and drying herbs in the formula, and mildly tonifies Qi. As the classical harmonizer, it moderates potential conflicts between the many warm-drying and cold-clearing herbs used together.

Why This Combination Works

How the herbs in Hua Shi Bai Du Fang complement each other

Overall strategy

This formula addresses a pattern where epidemic dampness-toxin invades and obstructs all three burners, with the Lungs as the primary target. The prescription logic uses a "three-burner" approach: clearing and opening the upper burner (Lungs), transforming dampness in the middle burner (Spleen and Stomach), purging toxins from the lower burner (intestines), while simultaneously supporting the body's own resistance to prevent collapse.

King herbs

Ma Huang and Shi Gao form the core pairing drawn from Ma Xing Shi Gan Tang. Ma Huang opens and disseminates Lung Qi to relieve wheezing and dyspnea, the most urgent symptom. Shi Gao, cold and heavy, clears the intense Heat generated by the epidemic toxin in the Lungs. Together they clear Lung Heat without trapping pathogens (Shi Gao prevents Ma Huang from generating more Heat) and open the airways without causing cold-stagnation (Ma Huang prevents Shi Gao from constricting Lung Qi). This pairing directly targets the upper burner, where the disease is most acute.

Deputy herbs

Cang Zhu and Huo Xiang are the principal dampness-transforming herbs, addressing the middle burner. Cang Zhu powerfully dries dampness and awakens the Spleen, while Huo Xiang aromatically penetrates turbid dampness and stops nausea. Xing Ren assists the King herbs by descending Lung Qi to complement Ma Huang's ascending action, restoring the Lung's rhythmic function. Together, the Deputies ensure that dampness in the Spleen and phlegm in the Lungs are both addressed.

Assistant herbs

Reinforcing assistants: Hou Po and Cao Guo, from the Da Yuan Yin lineage, penetrate to the membrane source where epidemic pathogens lodge, breaking open dampness-turbidity deep in the body. Ban Xia dries phlegm and descends rebellious Stomach Qi. Fu Ling drains dampness downward through urination and supports the Spleen. Ting Li Zi powerfully drains phlegm-fluids from the Lung, addressing severe respiratory congestion.

Restraining assistants: Huang Qi tonifies the body's Qi to prevent the strong pathogen-expelling herbs from depleting the patient further, drawing on the Yu Ping Feng San principle of supporting defensive Qi. Chi Shao cools and moves Blood, preventing the Heat-toxin from entering the Blood level and addressing the Blood stasis that develops in severe infections.

Purging assistant: Da Huang at a small dose (5g) clears Heat-toxin downward through the bowels, providing a crucial exit route. This reflects the Cheng Qi Tang tradition of "opening the lower orifice" to resolve upper congestion.

Envoy herbs

Gan Cao harmonizes the entire formula, protecting the Stomach from the combined drying and cold-clearing herbs, and ensuring the many disparate herbal actions work as a coordinated whole rather than at cross-purposes.

Notable synergies

Ma Huang + Shi Gao: The classic Ma Xing Shi Gan Tang core. Ma Huang opens the Lung; Shi Gao clears Lung Heat. Neither is too warm nor too cold when combined. Cang Zhu + Huo Xiang + Cao Guo + Hou Po: A concentrated dampness-transforming cluster that works across the membrane source and middle burner. Huang Qi + Chi Shao: From the Huang Qi Chi Feng Tang tradition, this pairing simultaneously supports Qi and moves Blood, addressing the immune depletion and microvascular damage seen in severe infections. Ting Li Zi + Da Huang: A top-and-bottom drainage pair, one draining phlegm-fluids from the Lung above, the other purging Heat-toxin through the intestines below, creating powerful downward elimination.

How to Prepare

Traditional preparation instructions for Hua Shi Bai Du Fang

As a traditional decoction: use one to two doses per day. Decoct in water. Sheng Shi Gao (Gypsum) should be decocted first for 30 minutes (先煎) before adding the other herbs. Guang Huo Xiang (Patchouli) and Sheng Da Huang (Rhubarb) should be added in the last 5 minutes (后下) of the decoction process. Take 100-200 mL per dose, 2 to 4 times daily, by mouth or via nasogastric tube for patients unable to swallow.

The formula is also commercially available as Hua Shi Bai Du Ke Li (化湿败毒颗粒), a concentrated granule preparation approved by China's NMPA in March 2021. Follow the manufacturer's dosing instructions for the granule form.

Common Modifications

How practitioners adapt Hua Shi Bai Du Fang for specific situations

Added
Shi Gao

Increase Shi Gao to 30g to strengthen Heat-clearing

Zhi Mu

Add 9-12g to enhance clearing of Qi-level Heat and protect Yin fluids

When Heat is dominant and fever persists, increasing Shi Gao and adding Zhi Mu creates a Bai Hu Tang dynamic that more powerfully clears Qi-level Heat while protecting body fluids from damage.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Hua Shi Bai Du Fang should not be used or requires extra caution

Avoid

Yin deficiency with Heat signs and dry constitution lacking Dampness. The formula is strongly aromatic, drying, and dispersing, and could further damage Yin fluids in patients without a Damp-Toxic pattern.

Avoid

Exterior Wind-Cold without internal Dampness or Heat. The strong clearing and draining actions are inappropriate for simple exterior Cold patterns.

Avoid

Patients with active gastrointestinal bleeding or severe bleeding disorders, as the formula contains Da Huang (Rhubarb) which promotes bowel movement and Chi Shao (Red Peony) which invigorates Blood.

Caution

Patients with Spleen-Stomach Yang deficiency and chronic loose stools. Shi Gao (Gypsum), Da Huang, and Ting Li Zi are all cold or draining in nature and may worsen digestive weakness.

Caution

Concurrent use of strong immunosuppressive medications requires medical supervision, as the formula's immune-modulating actions may interact unpredictably.

Caution

Patients with known hypersensitivity to any of the 14 constituent herbs should avoid the formula or use under close supervision.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The formula contains several herbs of concern: Ma Huang (Ephedra) can stimulate uterine contractions; Da Huang (Rhubarb) is a purgative with known uterotonic effects and is listed as contraindicated in pregnancy in standard Chinese Materia Medica references; Ting Li Zi (Descurainia/Lepidium seeds) has strong draining properties. Ban Xia (Pinellia) is traditionally listed among pregnancy-prohibited herbs. Chi Shao (Red Peony) invigorates Blood and may increase risk of bleeding. This formula should not be used during pregnancy unless the clinical situation is life-threatening and no safer alternatives exist, and then only under direct supervision of a qualified physician.

Breastfeeding

Use with caution during breastfeeding. Ma Huang (Ephedra) contains ephedrine and pseudoephedrine, which are known to transfer into breast milk and may cause irritability, poor feeding, or sleep disturbance in nursing infants. Da Huang (Rhubarb) contains anthraquinone compounds that can pass into breast milk and may cause loose stools or colic in the infant. Given that this is an acute-use formula designed for epidemic illness, short-term use under medical supervision may be acceptable if clinically necessary, but the infant should be monitored closely. Consult a qualified practitioner before use while breastfeeding.

Children

One clinical trial studied Huashi Baidu granule in children aged 3 to 18 years with mild COVID-19, suggesting it can be used in pediatric populations with appropriate dose adjustments. For children aged 3 to 6 years, the dose is typically reduced to one-third to one-half of the adult dose; for children aged 7 to 14, approximately half to two-thirds of the adult dose. The formula contains Ma Huang (Ephedra), which may cause restlessness or sleep disturbance in young children and should be used cautiously. Da Huang (Rhubarb) may cause loose stools more readily in children due to their immature digestive systems. This formula is not recommended for infants under 3 years of age. All pediatric use should be under the direct supervision of a qualified practitioner.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Hua Shi Bai Du Fang

Ma Huang (Ephedra) contains ephedrine and pseudoephedrine. These sympathomimetic alkaloids may interact with MAO inhibitors (risk of hypertensive crisis), beta-blockers, cardiac glycosides (digoxin), and other sympathomimetic drugs. Patients on antihypertensive medications should be monitored for reduced drug efficacy.

Gan Cao (Licorice root) contains glycyrrhizin, which can cause pseudoaldosteronism (potassium loss, sodium retention, edema). It may interact with corticosteroids (additive mineralocorticoid effects), digoxin (hypokalemia increases digoxin toxicity), diuretics (especially thiazides and loop diuretics, compounding potassium loss), and antihypertensives (counteracting blood pressure lowering effects).

Da Huang (Rhubarb) contains anthraquinones with laxative properties. It may reduce absorption of orally administered drugs if diarrhea occurs, and chronic use can cause potassium depletion that potentiates cardiac glycoside toxicity. It may also interact with anticoagulants and antiplatelet drugs, as its Blood-invigorating action may increase bleeding risk.

Huang Qi (Astragalus) has immunostimulant properties. It should be used cautiously alongside immunosuppressive drugs (cyclosporine, tacrolimus, corticosteroids) as it may counteract immunosuppressive effects. Patients on anticoagulant therapy (warfarin) should be monitored, as Astragalus may modestly affect bleeding parameters.

Usage Guidance

Practical advice for getting the most out of Hua Shi Bai Du Fang

Best time to take

Twice daily, 30 to 60 minutes after meals (to reduce potential gastrointestinal irritation from Da Huang and Ma Huang), morning and evening.

Typical duration

Acute use: typically 7 to 14 days, reassessed by a practitioner based on symptom improvement and disease progression.

Dietary advice

During the course of treatment, avoid cold and raw foods (such as salads, ice cream, chilled beverages, and raw fruit) as these can impair the Spleen's ability to transform Dampness, directly opposing the formula's therapeutic aim. Also avoid greasy, fried, and rich foods, as these generate Dampness and Phlegm internally. Dairy products and excessively sweet foods should be minimized for the same reason. Light, easily digestible warm foods such as plain rice congee, steamed vegetables, mung bean soup, and clear broths are ideal. Avoid alcohol, which generates Damp-Heat. Spicy foods in moderation (ginger, scallion) are acceptable and may support the formula's dispersing function.

Hua Shi Bai Du Fang originates from Developed by Huang Luqi (黄璐琦) and the National TCM Medical Team (China Academy of Chinese Medical Sciences) during the COVID-19 pandemic in Wuhan, 2020. Included in the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Versions 6-9) issued by China's National Health Commission. Modern, 2020 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Hua Shi Bai Du Fang and its clinical use

Although Hua Shi Bai Du Fang (化湿败毒方) is a modern formula created in 2020, its theoretical foundation draws from principles articulated in classical texts and the component formulas come from canonical sources:

  • From the treatment principles underlying Ma Xing Shi Gan Tang (Shang Han Lun, Zhang Zhongjing):
    「汗出而喘,无大热者,麻杏甘石汤主之」
    "When there is sweating with wheezing and no great fever, Ma Xing Gan Shi Tang governs it."
    This classical formula forms the upper Jiao layer of Hua Shi Bai Du Fang, using Ma Huang, Shi Gao, Xing Ren, and Gan Cao for ventilating the Lungs and clearing Heat.
  • From Da Yuan Yin (Wen Yi Lun, Wu Youke, Ming Dynasty):
    「邪自口鼻而入,则其所客,内不在脏腑,外不在经络,舍于伏脊之内,去表不远,附近于胃,乃表里之分界,是为半表半里」
    "When pathogenic Qi enters through the mouth and nose, it lodges not in the Zang-Fu nor in the channels, but in the membrane source between the exterior and interior."
    This passage justifies the use of Huo Xiang, Cang Zhu, Hou Po, Cao Guo, and Ban Xia to penetrate the membrane source and transform Dampness in the middle Jiao.
  • Principle from the Wen Bing tradition on epidemic Dampness-Heat:
    「湿热之邪,从口鼻而入,阻于气分,蕴蒸不化」
    "Damp-Heat pathogenic factors enter through the mouth and nose, obstruct the Qi level, and steam without transforming."
    This captures the core pathomechanism that Hua Shi Bai Du Fang addresses: a pestilential Damp-Toxic pathogen that blocks all three burners.

Historical Context

How Hua Shi Bai Du Fang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Hua Shi Bai Du Fang (化湿败毒方, "Dampness-Transforming Toxin-Defeating Formula") is a modern formula created in early 2020 during the COVID-19 pandemic in Wuhan, China. It was developed by the first National TCM Medical Team dispatched to Wuhan, led by Huang Luqi (黄璐琦), an academician of the Chinese Academy of Engineering and president of the China Academy of Chinese Medical Sciences. The team was stationed at Wuhan Jinyintan Hospital, where they managed severe COVID-19 patients and refined the formula through iterative clinical practice.

The formula drew on the wisdom of multiple classical prescriptions. Its upper Jiao component derives from Ma Xing Shi Gan Tang (from the Shang Han Lun) and Xuan Bai Cheng Qi Tang (from the Wen Bing Tiao Bian); its middle Jiao component from Da Yuan Yin (from Wu Youke's Wen Yi Lun) and Huo Xiang Zheng Qi San (from the Tai Ping Hui Min He Ji Ju Fang); its lower Jiao approach from Tao Ren Cheng Qi Tang and Ting Li Da Zao Xie Fei Tang; and its Qi-supplementing aspect from Huang Qi Chi Feng Tang and Yu Ping Feng San. In March 2020, it became the first TCM formula to receive a clinical trial approval from China's National Medical Products Administration (NMPA) for treating COVID-19. It was officially approved as a commercial granule product in March 2021. International colleagues affectionately nicknamed it "Q-14" ("Q" for "cure" and 14 for its 14 herbs). It was incorporated into China's national COVID-19 treatment guidelines from version 6 onward and became one of the celebrated "Three Formulas and Three Medicines" (三方三药) that represented TCM's contribution to China's pandemic response.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Hua Shi Bai Du Fang

1

RCT: Combination of Hua Shi Bai Du Granule (Q-14) and Standard Care in COVID-19 Patients (2021)

Liu J, Yang W, Liu Y, et al. Phytomedicine. 2021;91:153671.

A single-center, open-label, randomized controlled trial at Wuhan Jinyintan Hospital enrolling 204 patients with confirmed COVID-19. Patients received Q-14 (10 g granules twice daily for 14 days) plus standard care, or standard care alone. The study found that Q-14 combined with standard care safely improved clinical symptoms in general-type COVID-19 patients, though the primary outcome of viral nucleic acid conversion time did not reach statistical significance.

2

PNAS Study: Bioactive Compounds from Huashi Baidu Decoction with Antiviral and Anti-inflammatory Effects against COVID-19 (2023)

Xu H, Zhong Y, Yang J, et al. Proceedings of the National Academy of Sciences. 2023;120(18):e2301775120.

Using integrative pharmacological methods, researchers characterized 343 chemical compounds from Q-14, traced 60 prototype compounds in plasma, and identified key bioactive molecules with both antiviral activity against SARS-CoV-2 main protease and anti-inflammatory effects. The study demonstrated that the formula's therapeutic mechanism involves a synergistic combination of direct antiviral and immunomodulatory actions.

3

Pediatric RCT: Huashi Baidu Granule in Pediatric Patients with Mild COVID-19 (Omicron) (2023)

Chen J, Tang Q, Zhang B, et al. Frontiers in Pharmacology. 2023;14:1092748.

A single-center, open-label, randomized controlled trial in Shanghai enrolling 108 children aged 3 to 18 years with mild COVID-19 caused by the Omicron variant. The study assessed the efficacy and safety of Huashi Baidu granule administered orally for five consecutive days, providing early evidence on its use in the pediatric population.

4

RCT: Huashi Baidu Granule vs. Nirmatrelvir-Ritonavir (Paxlovid) in High-Risk Omicron Patients (2023)

Yu Z, Zheng Y, Chen B, et al. Phytomedicine. 2023;120:155025.

A prospective single-center, open-label, randomized controlled trial in Shanghai comparing Huashi Baidu granule monotherapy, Paxlovid monotherapy, and combination therapy in 312 high-risk patients infected with the Omicron variant. The study found that the viral nucleic acid negative conversion time was not significantly different between the Huashi Baidu granule and Paxlovid groups.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.