Herb Root (根 gēn)

Chai Hu

Bupleurum root · 柴胡

Bupleurum chinense DC. · Radix Bupleuri

Also known as: North Bupleurum (北柴胡 Běi Chái Hú), South Bupleurum (南柴胡 Nán Chái Hú), Bupleurum scorzonerifolium Willd. (narrow-leaf species),

Images shown are for educational purposes only

Bupleurum root is one of the most widely used herbs in Chinese medicine, valued for its ability to relieve stress-related tension, support healthy mood, and ease symptoms of colds and fevers. It is best known for helping the body's Liver system maintain a smooth, free-flowing state, which makes it a go-to herb for conditions driven by emotional stress, including rib-side discomfort, irritability, and menstrual irregularities.

TCM Properties

Temperature

Slightly Cool

Taste

Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)

Channels entered

Liver, Gallbladder, Lungs

Parts used

Root (根 gēn)

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What This Herb Does

Every herb has a specific set of actions — here's what Chai Hu does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Chai Hu is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Chai Hu performs to restore balance in the body:

How these actions work

'Disperses exterior conditions and reduces fever' means Chai Hu helps the body fight off the early stages of colds and infections by pushing out pathogens from the surface of the body. It is especially useful for fevers that alternate with chills, a hallmark symptom of the Shaoyang stage of illness. Clinically this is its most prominent action when used in larger doses (6–12g).

'Spreads Liver Qi and relieves constraint' is the action most people associate with Chai Hu. The Liver in TCM is responsible for the smooth flow of Qi throughout the body. When emotional stress, frustration, or suppressed anger causes Liver Qi to stagnate, symptoms like rib-side pain, a feeling of tightness in the chest, mood swings, irritability, and irregular menstruation can appear. Chai Hu's pungent and slightly cool nature gently moves the stagnant Liver Qi and restores its free flow. This is why it is called the 'key herb for Liver Qi stagnation' and appears in almost every major Liver-coursing formula. Vinegar-processed Chai Hu (Cù Chái Hú) is preferred for this purpose.

'Raises Yang Qi' refers to Chai Hu's light, upward-moving character. When used in small doses (3–6g) alongside Qi-tonifying herbs like Huang Qi and Dang Shen, it helps lift the body's Qi upward. This is relevant for conditions where Qi has 'sunk' downward, causing symptoms like chronic diarrhea, rectal prolapse, or uterine prolapse. In this context it works as an assistant herb rather than the lead.

'Harmonizes the Shaoyang' describes Chai Hu's signature role in resolving conditions where a pathogen is lodged between the body's exterior and interior (the 'half-exterior, half-interior' zone governed by the Shaoyang). The classic presentation is alternating chills and fever, fullness in the chest and ribs, a bitter taste in the mouth, nausea, and a wiry pulse. Chai Hu paired with Huang Qin forms the core structure for this harmonizing strategy.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony. Chai Hu is used to help correct these specific patterns.

Why Chai Hu addresses this pattern

Chai Hu is the primary herb for Liver Qi Stagnation. Its pungent taste disperses and moves stagnant Qi, while its bitter taste helps descend and drain. It enters the Liver and Gallbladder channels directly, allowing it to restore the smooth flow of Liver Qi that has become 'knotted' due to emotional stress, frustration, or suppressed anger. When Liver Qi stagnates, it fails to spread smoothly through the rib-side region (the pathway of the Liver and Gallbladder channels), causing distension and pain there. Chai Hu's light, dispersing nature opens this congestion. Its slightly cool temperature also prevents stagnant Qi from transforming into Heat, a common complication of prolonged Liver constraint.

A practitioner would look for one or more of these signs

Rib Pain

Distending pain along the rib-side that worsens with emotional stress

Chest Stiffness

Feeling of fullness and tightness in the chest

Irritability

Mood swings, irritability, frequent sighing

Irregular Menstruation

Menstrual irregularity with premenstrual breast distension

Depression

Emotional depression and low mood

Commonly Used For

These are conditions where Chai Hu is frequently used — but only when they arise from the specific patterns it addresses, not in all cases

TCM Interpretation

In TCM, many forms of depression are understood as disorders of Liver Qi flow. The Liver governs the smooth circulation of Qi throughout the body and is closely tied to emotional processing. When stress, frustration, grief, or suppressed feelings cause the Liver Qi to become 'knotted' or stagnant, the person may feel stuck, low in mood, easily irritated, and physically tight across the chest and flanks. Over time, this stagnation can affect the Spleen (causing poor appetite and fatigue) and generate internal Heat (causing restlessness and insomnia). TCM sees this as a functional disruption of Qi movement rather than a chemical imbalance, though the clinical presentation overlaps significantly with biomedical depression.

Why Chai Hu Helps

Chai Hu directly enters the Liver and Gallbladder channels and has a pungent, dispersing nature that reopens the flow of stagnant Liver Qi. Its slightly cool temperature prevents the stagnation from generating excess Heat. In classical formulas for depression, Chai Hu serves as the lead herb that 'unlocks' the constrained Qi, while partner herbs like Bai Shao nourish the Liver's substance and prevent Chai Hu's dispersing nature from depleting Yin. Modern pharmacological research has identified anti-inflammatory and neuromodulatory effects of saikosaponins that may contribute to its antidepressant actions. Formulas containing Chai Hu (such as Xiao Yao San and Chai Hu Shu Gan San) have been studied in clinical trials for depression with some positive findings, though the evidence quality remains modest.

Also commonly used for

Intercostal Neuralgia

Rib-side pain and chest-flank discomfort

Common Cold

Febrile illness with alternating chills and fever

Cholecystitis

Gallbladder inflammation with rib-side pain and bitter taste

Irritable Bowel Syndrome

Stress-related digestive disturbance with Liver-Spleen disharmony

Gastric Prolapse

Organ prolapse due to Qi sinking, often combined with Qi tonics

Malaria

Classical indication for alternating chills and fever

Herb Properties

Every herb has an inherent temperature, taste, and affinity for specific channels — these properties determine how it interacts with the body

Temperature

Slightly Cool

Taste

Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)

Channels Entered

Liver Gallbladder Lungs

Parts Used

Root (根 gēn)

Dosage & Preparation

These are general dosage guidelines for Chai Hu — always follow your practitioner's recommendation, as dosages vary based on the formula and your individual condition

Standard dosage

3-10g

Maximum dosage

Up to 15-20g in acute febrile conditions under practitioner supervision. Zhang Zhongjing's original Xiao Chai Hu Tang used large amounts (half a jin, roughly equivalent to modern doses of 20-40g), but modern clinical practice typically stays within 3-15g.

Dosage notes

Lower doses (3-6g) are used for raising sunken Yang Qi (as in Bu Zhong Yi Qi Tang). Medium doses (6-10g) are standard for coursing Liver Qi and relieving depression (as in Chai Hu Shu Gan San or Xiao Yao San). Higher doses (10-15g or more) are used for dispersing exterior Heat and harmonizing the Shaoyang (as in Xiao Chai Hu Tang). Raw Chai Hu (Sheng Chai Hu) has stronger ascending and dispersing action and is preferred for releasing the exterior and reducing fever. Vinegar-processed Chai Hu (Cu Chai Hu) has a gentler ascending quality and enhanced ability to course Liver Qi and relieve pain. Turtle-blood-processed Chai Hu (Bie Xue Chai Hu) nourishes Yin and is used for Heat entering the Blood Chamber and steaming bone fever.

Preparation

No special decoction handling is required. Chai Hu is added with the other herbs and decocted normally. However, the volatile oils that contribute to its exterior-releasing action are partially lost with prolonged boiling, so some practitioners prefer not to decoct it for excessively long periods when using it for its diaphoretic function.

Processing Methods

In TCM, the same herb can be prepared in different ways to change its effects — here's how processing alters what Chai Hu does

Processing method

Chai Hu slices are stir-fried with rice vinegar until dry. Typical ratio: 20kg vinegar per 100kg herb.

How it changes properties

Vinegar processing moderates Chai Hu's ascending and dispersing nature. It enhances the herb's ability to spread Liver Qi, relieve Liver constraint, and stop pain, while reducing the outward-dispersing fever-reducing action. The thermal nature remains slightly cool but the action becomes more focused on the Liver channel.

When to use this form

Preferred when the main goal is to soothe Liver Qi stagnation causing rib-side pain, chest tightness, abdominal pain, or menstrual irregularity. This is the standard form for formulas targeting emotional and Liver-related conditions like Chai Hu Shu Gan San and Xiao Yao San.

Common Herb Pairs

These ingredients are traditionally combined with Chai Hu for enhanced therapeutic effect

Huang Qin
Huang Qin Chai Hu 12–24g : Huang Qin 9g (in Xiao Chai Hu Tang, Chai Hu is used at roughly 2:1 to Huang Qin)

Chai Hu and Huang Qin form the classical 'harmonizing pair' for the Shaoyang. Chai Hu, pungent and slightly cool, pushes the pathogen outward from the half-exterior zone and lifts clear Yang. Huang Qin, bitter and cold, clears Heat from the half-interior zone and descends turbid fire. Together they create a complementary ascending-descending dynamic that resolves the Shaoyang stagnation that neither herb can fully address alone.

When to use: The Shaoyang pattern with alternating fever and chills, rib-side fullness, bitter taste, nausea, and a wiry pulse. Also used for Liver-Gallbladder Damp-Heat conditions and febrile diseases.

Bai Shao
Bai Shao 1:1 to 1:2 (Chai Hu 6–10g : Bai Shao 10–15g)

Chai Hu spreads Liver Qi (the Liver's 'Yang function') while Bai Shao nourishes Liver Blood and softens the Liver (the Liver's 'Yin substance'). This pairing embodies the principle that the Liver is 'Yin in body, Yang in function.' Chai Hu moves what is stuck, and Bai Shao prevents this movement from depleting the Liver's Blood and Yin reserves. Together they soothe Liver Qi without causing dryness or damage to Yin.

When to use: Liver Qi stagnation with underlying Blood deficiency: rib-side pain, emotional tension, irregular menstruation, premenstrual breast distension. This is a near-universal pairing found in most Liver-soothing formulas.

Sheng Ma
Sheng Ma 1:1 (Chai Hu 3–6g : Sheng Ma 3–6g, both in small doses as assistant herbs in Bu Zhong Yi Qi Tang)

Both Chai Hu and Sheng Ma have ascending, upward-lifting properties, but they enter different channels. Chai Hu lifts through the Liver and Gallbladder (left side, Shaoyang), while Sheng Ma lifts through the Stomach and Spleen (Yangming). Together they create a balanced bilateral upward force that raises sunken Yang Qi more effectively than either herb alone.

When to use: Spleen Qi sinking with organ prolapse (rectal prolapse, uterine prolapse, gastroptosis), chronic diarrhea from Qi deficiency, or the 'Qi sinking' pattern. Always used alongside Qi-tonifying herbs like Huang Qi.

Xiang Fu
Xiang Fu 1:1 (Chai Hu 6–10g : Xiang Fu 6–10g)

Both herbs move Liver Qi, but they work through different mechanisms. Chai Hu disperses constraint through its upward, outward movement; Xiang Fu resolves stagnation by smoothing and regulating Qi flow horizontally. Together they provide a more thorough resolution of Liver Qi stagnation, addressing both the Liver channel itself and the broader Qi dynamic.

When to use: Liver Qi stagnation with prominent pain: rib-side pain, chest distension, epigastric pain, and menstrual pain aggravated by emotional stress.

Key Formulas

These well-known formulas feature Chai Hu in a prominent role

Xiao Chai Hu Tang 小柴胡湯 King

The definitive Shaoyang-harmonizing formula from the Shang Han Lun, where Chai Hu is the undisputed king herb at the highest dose in the formula (half a jin in the original). It showcases Chai Hu's core ability to resolve the half-exterior, half-interior condition through its ascending, dispersing nature paired with Huang Qin's descending, heat-clearing action. This formula is the foundation of the entire 'Chai Hu family' of prescriptions.

Xiao Yao San 逍遙散 King

The most widely used Liver-soothing formula from the Tai Ping Hui Min He Ji Ju Fang. Chai Hu serves as king to spread constrained Liver Qi, while the supporting herbs nourish Blood, strengthen the Spleen, and prevent the Liver from overacting on the Spleen. This formula perfectly demonstrates Chai Hu's role as the key herb for Liver Qi stagnation affecting the Spleen, and it is one of the most commonly prescribed formulas in modern TCM practice.

Chai Hu Shu Gan San 柴胡疏肝散 King

A key formula for Liver Qi stagnation with pain, derived from Si Ni San. Chai Hu leads the formula to course the Liver and relieve constraint, supported by Xiang Fu, Chuan Xiong, and Chen Pi for Qi-moving and Blood-activating effects. This formula highlights Chai Hu's specific strength in treating rib-side and flank pain from Liver constraint.

Bu Zhong Yi Qi Tang 補中益氣湯 Assistant

Li Dongyuan's signature formula for Spleen Qi deficiency with sinking Yang. Here Chai Hu is used in a small dose (3–6g) purely for its ascending nature, working alongside Sheng Ma to lift sunken Qi upward. This showcases Chai Hu's Yang-raising action and demonstrates how the same herb can serve entirely different therapeutic purposes depending on dosage and formula context.

Comparable Ingredients

These ingredients have overlapping uses — here's how to tell them apart

Ge Gen
Chai Hu vs Ge Gen

Both Chai Hu and Ge Gen are light, ascending herbs that release the exterior and reduce fever, so they are often used together. However, they differ in key ways: Chai Hu enters the Liver and Gallbladder and excels at spreading Liver Qi and harmonizing the Shaoyang, but it does not generate fluids. Ge Gen enters the Spleen and Stomach, generates fluids, relieves thirst, and raises Spleen Yang to treat diarrhea, but it cannot soothe Liver Qi. Choose Chai Hu when Liver constraint or Shaoyang involvement is present; choose Ge Gen when thirst, fluid damage, or Yangming-level symptoms predominate.

Bo He
Chai Hu vs Bo He

Both herbs enter the Liver channel and can spread Liver Qi, and both disperse Wind-Heat. Bo He (mint) is more aromatic and lighter, excelling at clearing the head and eyes, soothing the throat, and venting rashes. It is typically used in small doses as an assistant. Chai Hu is stronger at coursing Liver Qi for deep-seated emotional stagnation, harmonizing the Shaoyang, and raising Yang Qi. Choose Bo He for milder Liver constraint with head and eye symptoms; choose Chai Hu for more pronounced Liver Qi stagnation or Shaoyang patterns.

Qing Hao
Chai Hu vs Qing Hao

Both herbs treat alternating fever and chills and are used for Shaoyang-type conditions. However, Qing Hao (Sweet Wormwood) is cold and excels at clearing deficiency heat (bone-steaming tidal fever from Yin deficiency) and treating summerheat. Chai Hu is slightly cool and is better for resolving exterior pathogens from the Shaoyang, spreading Liver Qi, and raising Yang. Qing Hao is preferred when Yin deficiency heat is prominent; Chai Hu when the Shaoyang pattern or Liver Qi stagnation is the primary issue.

Common Substitutes & Adulterants

Related species and common adulterations to be aware of when sourcing Chai Hu

The most dangerous adulterant is Da Ye Chai Hu (大叶柴胡, Bupleurum longiradiatum), which is toxic and listed as unfit for medicinal use in the Chinese Pharmacopoeia. It can be distinguished by its larger, elliptical or spoon-shaped leaves, much taller growth habit (up to 140 cm), and a strong distinctive aroma. Its root shows dense nodes. Yin Chai Hu (银柴胡, Stellaria dichotoma) from the Caryophyllaceae family is sometimes confused with Chai Hu due to the similar name, but it is a completely different herb with different functions (clears deficiency Heat rather than dispersing exterior pathogens). Its root surface shows characteristic bead-like protrusions ('pearl dots'). Other substitutes include various regional Bupleurum species (over 25 species have been used as local substitutes), such as Hei Chai Hu (B. smithii), Yin Zhou Chai Hu (B. yinchowense), and Zhui Ye Chai Hu (B. bicaule). These have different saikosaponin profiles and pharmacological activities compared to the official species.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herb.

Toxicity Classification

Classical Chinese pharmacopoeia toxicity rating for Chai Hu

Non-toxic

Chai Hu is classified as non-toxic in the Chinese Pharmacopoeia at standard clinical doses. However, modern research has identified potential hepatotoxicity with prolonged use or excessive dosage. The saikosaponins (particularly saikosaponin d) and volatile oils are the main compounds responsible for possible liver injury at supra-therapeutic doses. Animal studies show that saikosaponins administered continuously at high doses for 15 days can cause liver cell damage and necrosis. Essential oils from B. chinense have been shown to cause hepatic injury at 1.5 to 3.4 times the standard clinical daily dosage. The large-leaf Bupleurum (B. longiradiatum) is a toxic species listed in the Chinese Pharmacopoeia as unfit for medicinal use, containing bupleurotoxin. It must never be substituted for authentic Chai Hu.

Contraindications

Situations where Chai Hu should not be used or requires extra caution

Caution

Yin deficiency with Heat signs (dry mouth, red tongue with little coating, night sweats). Chai Hu's ascending and dispersing nature can further damage Yin fluids and worsen deficiency Heat.

Caution

Liver Yang rising (hyperactive Liver Yang) with headache, dizziness, irritability, and high blood pressure. Chai Hu's upward-lifting quality can aggravate the upward flaring of Yang.

Caution

Loose stools or chronic diarrhea due to Spleen deficiency. Classical texts note Chai Hu has a slippery, free-flowing quality that can worsen diarrhea.

Caution

Qi or Blood deficiency without appropriate tonifying herbs in the formula. As the Ben Cao Qiu Zhen warns, Chai Hu's dispersing nature can scatter Qi if not paired with tonifiers like Dang Gui or Huang Qi.

Caution

Low blood pressure or bradycardia. Pharmacological research indicates Chai Hu can lower blood pressure and slow heart rate, so prolonged or high-dose use may worsen these conditions.

Caution

Diabetes or hyperglycemia. Chai Hu extracts have been shown to raise blood sugar levels in animal studies.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Chai Hu's ascending, dispersing, and Qi-moving properties may disturb fetal stability and potentially cause restless fetus. While it is not classified among the strictly prohibited pregnancy herbs, its ability to course Liver Qi and raise Yang means it should be avoided in pregnancy unless specifically indicated and prescribed by a qualified practitioner. Some classical formulas (such as Xiao Chai Hu Tang) have been used cautiously during pregnancy, but only under careful clinical supervision.

Breastfeeding

No specific classical or modern prohibitions for breastfeeding have been established for Chai Hu at standard doses. However, because Chai Hu's active saikosaponins could theoretically transfer into breast milk, it is generally advised to use with caution during lactation and only when clearly needed. Chai Hu's Qi-moving and dispersing properties should be considered in the context of a nursing mother's constitution.

Children

Chai Hu can be used in children at appropriately reduced doses, typically one-third to one-half of the adult dose depending on age and body weight. It has a long history of pediatric use in classical formulas for childhood fevers and alternating hot-cold patterns. The Ben Cao Gang Mu specifically notes its use for residual heat from childhood eruptions and consumptive heat from pediatric nutritional accumulation (gan). However, prolonged or high-dose use should be avoided in infants and young children. As with all herbs in pediatric use, a qualified practitioner should determine the appropriate dosage.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Chai Hu

Metal ion medications: Chai Hu contains quercetin, a flavonoid with multiple phenolic hydroxyl groups that can form chelation complexes with metal ions. It should not be taken concurrently with aluminum hydroxide preparations, calcium supplements, iron supplements, zinc preparations, or bismuth-containing drugs, as this may reduce the absorption and effectiveness of both the herb and the medication.

Vitamin C: Vitamin C can hydrolyze the glycosides (saponins) in Chai Hu into aglycones and sugars, potentially reducing therapeutic effectiveness. Concurrent use is not recommended.

Antihypertensive and cardiac medications: Chai Hu may lower blood pressure and slow heart rate; combined use with antihypertensives or negative chronotropic agents could cause excessive hypotension or bradycardia.

Hypoglycemic agents: Chai Hu has been shown to raise blood sugar in animal studies, which could potentially counteract the effects of diabetes medications. Monitor blood glucose levels.

Interferon therapy: In Japan, concurrent use of Xiao Chai Hu Tang with interferon-alpha for hepatitis treatment was associated with cases of interstitial pneumonia. This combination is now contraindicated in Japanese clinical guidelines.

Dietary Advice

Foods and dietary considerations when taking Chai Hu

When using Chai Hu to release the exterior or reduce fever, avoid cold and raw foods that could impede the herb's dispersing action. When using Chai Hu for Liver Qi stagnation, avoid excessive alcohol, greasy/fried foods, and excessively spicy foods that may generate Liver Heat or Damp-Heat. In general, a light, easily digestible diet supports the herb's therapeutic effects.

Botanical Description

Physical characteristics and morphology of the Chai Hu source plant

Bupleurum chinense DC. (North Chai Hu) is a perennial herb of the Apiaceae (Umbelliferae) family, growing 50–85 cm tall with erect, branching stems that are slightly zigzag-shaped in the upper portions. The leaves are alternate, broadly lanceolate to linear-lanceolate, 4–7 cm long and 6–13 mm wide, with prominent parallel veins and a tapering apex. The plant produces compound umbels with small yellow bisexual flowers from July to September, followed by ellipsoid brown fruits (schizocarps) that ripen from August to October. The root, the medicinal part, is long and conical with few branches, yellowish-brown on the surface, and tough and fibrous inside.

B. scorzonerifolium Willd. (South Chai Hu) is similar but with narrower, linear leaves (2–6 mm wide) and reddish-brown roots that are more brittle and break more easily. Both species grow in dry grasslands, sunny slopes, and edges of shrubby woodlands across northern and central China.

Sourcing & Harvesting

Where Chai Hu is sourced, when it's harvested or collected, and how to assess quality

Harvesting season

Spring and autumn. The roots are dug up, cleaned of stems, leaves, and soil, and dried.

Primary growing regions

North Chai Hu (Bei Chai Hu, B. chinense): Primary production regions are Henan, Hebei, and Liaoning provinces. Henan's Luoning County produces the highly regarded 'Wang Fan Chai Hu.' Shanxi, Shandong, and Inner Mongolia also produce significant quantities. South Chai Hu (Nan Chai Hu, B. scorzonerifolium): Primary production regions are Hubei, Jiangsu, and Sichuan provinces. As a traditional 'Northern herb' (bei yao), Chai Hu is categorized among the dao di yao cai of the northern Chinese regions (Hebei, Shanxi, Shandong, Inner Mongolia), where the dry grasslands and sunny slopes produce herb material with the highest saikosaponin content.

Quality indicators

North Chai Hu (Bei Chai Hu): Good quality roots are long, thick (0.3-0.8 cm diameter), firm but slightly flexible, with a yellowish-brown to dark brown surface showing longitudinal wrinkles and visible lenticels. The cross-section should be clearly fibrous, with a pale brown cortex and yellowish-white wood. The aroma should be faintly fragrant, and the taste mildly bitter and slightly pungent. The best-regarded variety is 'Wang Fan Chai Hu' from Luoning, Henan. Avoid roots that are hollow, dark inside, or excessively thin. South Chai Hu (Nan Chai Hu): Good quality shows a reddish-brown surface with prominent horizontal wart-like protuberances near the root head. It should break more crisply than the northern variety, with a relatively flat and pale brown cross-section. It has a slight oily/rancid smell.

Classical Texts

Key passages from the classical Chinese medical texts that describe Chai Hu and its therapeutic uses

Shen Nong Ben Cao Jing (《神农本草经》)

Chinese: 主心腹肠胃中结气,饮食积聚,寒热邪气,推陈致新。

English: Governs knotted Qi in the chest, abdomen, intestines, and stomach; accumulations from food and drink; pathogenic cold and heat; and promotes the expulsion of the old and renewal of the new.

Ben Cao Gang Mu (《本草纲目》, Li Shizhen)

Chinese: 治阳气下陷,平肝、胆、三焦、包络相火,头痛、眩晕,目昏、赤痛障翳,耳聋耳鸣,诸疟及肥气寒热,妇人热入血室,经水不调,小儿痘疹余热,五疳羸热。

English: Treats sinking of Yang Qi; calms ministerial Fire of the Liver, Gallbladder, Triple Burner, and Pericardium; headache, dizziness, blurred vision, red painful eyes with obstructive films, deafness and tinnitus; all forms of malaria and alternating cold and heat from masses; Heat entering the Blood Chamber in women and menstrual irregularity; lingering heat from childhood eruptions; and consumptive heat from the five types of gan accumulation.

Dian Nan Ben Cao (《滇南本草》)

Chinese: 伤寒发汗解表要药,退六经邪热往来,痹痿,除肝家邪热、劳热,行肝经逆结之气,止左胁肝气疼痛,治妇人血热烧经,能调月经。

English: An essential herb for inducing sweating and releasing the exterior in Cold Damage disorders; disperses alternating pathogenic Heat of the six channels; treats impediment and wilting; eliminates pathogenic Heat and consumptive Heat of the Liver; moves rebellious knotted Qi of the Liver channel; stops pain in the left hypochondrium from Liver Qi; treats women's menstrual scorching from Blood Heat; and regulates menstruation.

Historical Context

The history and evolution of Chai Hu's use in Chinese medicine over the centuries

Chai Hu was first recorded in the Shen Nong Ben Cao Jing (circa 1st-2nd century CE), where it was listed as a superior-grade (上品) herb. Its original name was written as 茈胡 (zi hu); the Xin Xiu Ben Cao (Tang Dynasty, 659 CE) notes that 茈 is an ancient form of the character 柴. The name 'Chai Hu' literally means 'firewood barbarian' or 'kindling plant,' likely referencing the tough, woody nature of the dried stems and roots.

Tao Hongjing (456-536 CE), in the Ben Cao Jing Ji Zhu, praised Chai Hu as the premier herb for treating Cold Damage disorders (伤寒第一用). It was Zhang Zhongjing (c. 150-219 CE) in the Shang Han Lun who established Chai Hu's central role in clinical medicine through Xiao Chai Hu Tang (Minor Bupleurum Decoction) and related formulas for Shaoyang-stage patterns. Li Dongyuan (1180-1251 CE) later expanded Chai Hu's application by using small doses in Bu Zhong Yi Qi Tang to lift sunken Yang Qi, establishing a second major use beyond harmonizing the Shaoyang.

It is important to distinguish Chai Hu from Yin Chai Hu (银柴胡, Stellaria dichotoma), which belongs to an entirely different plant family (Caryophyllaceae). These two herbs were historically confused and intermixed from the Tang Dynasty through to the Ming Dynasty, but are now recognized as completely different medicines with different actions: Chai Hu disperses exterior pathogenic factors and courses Liver Qi, while Yin Chai Hu clears deficiency Heat and is used for childhood nutritional accumulation.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Chai Hu

1

Systematic Review: Active saikosaponins and extracts isolated from Radix Bupleuri and their applications (2017)

Yuan B, Yang R, Ma Y, Zhou S, Zhang X, Liu Y. Pharmaceutical Biology, 2017, 55(1): 620-635.

This systematic review examined 128 studies and found that the major saikosaponins (SSa, SSd, SSc, SSb2) from Chai Hu demonstrate anti-inflammatory, antitumor, antiviral, anti-allergic, immunoregulatory, and neuroregulatory activities, primarily through NF-kB and MAPK signaling pathways. The review also noted that the main side effect of Radix Bupleuri is liver damage when dosage is excessive.

Link
2

Comprehensive Review: Pharmacology and toxicology of saikosaponins (2020)

Yuan B, et al. Acta Pharmaceutica Sinica B, 2020.

A comprehensive review of 165 studies covering the pharmacological and toxicological effects of saikosaponins. Confirmed anti-inflammatory, anti-tumor, anti-viral, and hepatoprotective effects, while highlighting the critical importance of dose-dependent safety, as overdose can cause hepatotoxicity through mitochondrial apoptosis in hepatocytes.

PubMed
3

Review: Radix Bupleuri - Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology (2017)

Yang F, Dong X, Yin X, Wang W, You L, Ni J. BioMed Research International, 2017, 2017: 7597596.

A comprehensive review covering over 2000 years of medicinal use of Radix Bupleuri. Summarized the major chemical components including triterpenoid saikosaponins, polyacetylenes, flavonoids, lignans, and essential oils. Documented pharmacological activities including central nervous system protection, liver protection, antiviral, and anti-tumor effects.

PubMed
4

Review: Pharmacology and toxicology of Bupleurum root-containing Kampo medicines in clinical use (2006)

Ikegami F, Sumino M, Fujii Y, Akiba T, Satoh T. Human & Experimental Toxicology, 2006, 25(8): 481-494.

Reviewed the safety profile of Bupleurum-containing formulas (Kampo medicines) used in Japanese clinical practice. Documented rare cases of interstitial pneumonia and hepatic dysfunction associated with Sho-saiko-to (Xiao Chai Hu Tang) in patients with chronic liver disease, particularly when combined with interferon therapy. This led to regulatory warnings in Japan.

PubMed

Research on individual TCM herbs is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.