Tian Ma Gou Teng Yin

Gastrodia and Uncaria Decoction · 天麻鉤藤飲

Also known as: Gastrodia and Gambir Combination, Tianma Gouteng Decoction

A modern formula designed to calm an overactive Liver and settle internal Wind, used for headaches, dizziness, and insomnia caused by rising Liver Yang. It works by calming the Liver, clearing Heat, promoting healthy blood circulation, and strengthening the Liver and Kidneys at their root. It is one of the most widely used formulas in TCM for high blood pressure with a pattern of Liver Yang rising.

Origin Zhōng Yī Nèi Kē Zá Bìng Zhèng Zhì Xīn Yì (中医内科杂病证治新义) by Hú Guāngcí (胡光慈) — Modern China, 1958 CE
Composition 11 herbs
Tian Ma
King
Tian Ma
Gou Teng
King
Gou Teng
Shi Jue Ming
Deputy
Shi Jue Ming
Chuan Niu Xi
Deputy
Chuan Niu Xi
Zhi Zi
Assistant
Zhi Zi
Huang Qin
Assistant
Huang Qin
Du Zhong
Assistant
Du Zhong
Sang Ji Sheng
Assistant
Sang Ji Sheng
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Tian Ma Gou Teng Yin is designed to correct these specific patterns.

Why Tian Ma Gou Teng Yin addresses this pattern

Liver Yang Rising is the primary pattern this formula targets. When the Liver and Kidneys become deficient (often due to chronic stress, aging, or constitutional weakness), they can no longer anchor Liver Yang, which then flares upward. This causes headache, dizziness, tinnitus, and flushed face. The formula addresses this with Tian Ma and Gou Teng to calm Liver Yang, Shi Jue Ming to weigh it down, and Chuan Niu Xi to redirect Blood downward. Meanwhile, Du Zhong and Sang Ji Sheng nourish the Liver and Kidneys to restore the root, and Zhi Zi with Huang Qin clear the Heat generated by the excess Yang. The spirit-calming herbs Ye Jiao Teng and Zhu Fu Shen address the insomnia that results from Yang disturbing the Heart.

A practitioner would look for one or more of these signs

Headaches

Distending headache at the temples or vertex, worse with stress or anger

Dizziness

Dizziness and vertigo, often with a sensation of the head being heavy or swollen

Insomnia

Difficulty falling or staying asleep, with vivid or disturbing dreams

Tinnitus

Ringing in the ears that worsens with emotional upset

Facial Flushing

Red face, especially when agitated or stressed

Bitter Taste In The Mouth

Bitter taste in the mouth, indicating Liver Heat

Tremors

Trembling or involuntary movements of the limbs

Irritability

Irritability and restlessness

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Tian Ma Gou Teng Yin when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Liver Yang Rising

TCM Interpretation

In TCM, hypertension most commonly corresponds to the pattern of Liver Yang Rising. The Liver is responsible for the smooth flow of Qi throughout the body, and when it becomes imbalanced, Yang (the active, rising aspect) can escape upward. This often happens when chronic stress, emotional strain, or aging depletes the Liver and Kidneys, leaving insufficient Yin (the cooling, anchoring aspect) to keep Yang rooted. The upward surge of Yang to the head produces the characteristic symptoms: headache, dizziness, red face, irritability, and a wiry pulse. The original source text explicitly designed this formula for hypertensive headache caused by what it termed "Liver reversal" (肝厥证), where Liver Fire flares upward and attacks the head.

Why Tian Ma Gou Teng Yin Helps

Tian Ma Gou Teng Yin directly addresses the mechanism behind Liver Yang type hypertension from multiple angles. Tian Ma and Gou Teng calm the Liver and settle Wind, reducing the upward surge. Shi Jue Ming anchors the Yang with its heavy mineral nature. Chuan Niu Xi directs Blood downward, reducing pressure in the head. Zhi Zi and Huang Qin clear the Heat that excess Yang generates. Du Zhong and Sang Ji Sheng strengthen the Liver and Kidneys at their root, addressing why Yang rose in the first place. Modern pharmacological research has confirmed that many herbs in this formula have vasodilating and blood-pressure-lowering effects through multiple pathways, including dilating peripheral blood vessels, reducing vascular resistance, and regulating nervous system activity.

Also commonly used for

Headaches

Hypertensive headache or migraine associated with Liver Yang Rising

Tinnitus

Ringing in the ears associated with Liver Yang Rising

Stroke

Acute cerebrovascular events where Liver Yang and Wind are involved

Meniere's Disease

Inner ear vertigo with a Liver Yang Rising presentation

Tremors

Involuntary tremor related to Liver Wind, including early Parkinson's presentations

Epilepsy

When the pattern involves Liver Wind and Liver Yang

Menopausal Symptoms

Perimenopausal symptoms with Liver Yang Rising pattern including hot flushes, headache, and insomnia

What This Formula Does

Every TCM formula has a specific set of actions — here's what Tian Ma Gou Teng Yin does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Tian Ma Gou Teng Yin is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Tian Ma Gou Teng Yin performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Tian Ma Gou Teng Yin works at the root level.

The pattern addressed by Tian Ma Gou Teng Yin arises when the Liver and Kidneys become gradually depleted, typically through chronic stress, overwork, ageing, or constitutional weakness. In TCM theory, the Kidneys store Yin (the body's cooling, nourishing, and anchoring substance), while the Liver depends on adequate Kidney Yin to keep its Yang in check. When Kidney Yin is insufficient, Liver Yang loses its anchor and flares upward uncontrollably, much like a fire that burns higher when fuel is consumed but nothing dampens it. This is Liver Yang Rising (肝阳上亢).

When Liver Yang rises excessively, it generates internal Wind, an invisible turbulence that stirs in the upper body and head. Wind in the head causes headache, dizziness, and a sensation of spinning or unsteadiness. Because the nature of Yang is hot and active, the rising Yang also transforms into Heat that disturbs the Heart and Spirit, producing irritability, restlessness, dream-disturbed sleep, and insomnia. The face may flush red, the mouth tastes bitter, the tongue turns red with a yellow coating, and the pulse becomes wiry (taut like a guitar string) or rapid. This is a pattern of "root deficiency with branch excess" (本虚标实): the root problem is Liver-Kidney insufficiency, but the urgent, dominant symptoms come from the excess Yang and Wind stirring above.

In modern clinical terms, this pathomechanism maps closely onto hypertension with associated symptoms of headache, vertigo, and sleep disturbance. The formula's strategy addresses both the acute excess (subduing Yang, extinguishing Wind, clearing Heat) and the underlying deficiency (nourishing the Liver and Kidneys), while also calming the disturbed Spirit to restore sleep.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter and sweet with a salty undertone — bitter to clear Heat and descend, sweet to tonify and harmonise, salty to anchor Yang and soften hardness.

Channels Entered

Ingredients

11 herbs

The herbs that make up Tian Ma Gou Teng Yin, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Kings — Main ingredient driving the formula
Tian Ma

Tian Ma

Gastrodia rhizomes

Dosage 9g
Temperature Neutral
Taste Sweet
Organ Affinity Liver

Role in Tian Ma Gou Teng Yin

Calms the Liver and extinguishes Wind. As one of the two King herbs, Tian Ma directly addresses the core pathomechanism of Liver Wind stirring upward, relieving headache, dizziness, and tremor.
Gou Teng

Gou Teng

Gambir stems and thorns

Dosage 12g
Temperature Cool
Taste Sweet
Organ Affinity Liver, Pericardium
Preparation Added in the last 5 minutes of decoction (后下) to preserve its active alkaloids, which are destroyed by prolonged boiling.

Role in Tian Ma Gou Teng Yin

Clears Heat from the Liver channel and extinguishes Wind. Paired with Tian Ma as co-King, its cool nature complements Tian Ma's balanced nature to powerfully calm Liver Yang and stop spasms.
Deputies — Assists and enhances the King
Shi Jue Ming

Shi Jue Ming

Abalone shells

Dosage 18g
Temperature Cold
Taste Salty
Organ Affinity Kidneys, Liver, Lungs
Preparation Decocted first for 30 minutes (先煎) due to its hard mineral nature.

Role in Tian Ma Gou Teng Yin

Heavy, salty, and cold, it anchors rising Yang and subdues the Liver. Reinforces the King herbs' Wind-calming action and adds the downward-directing weight of a mineral/shell substance to pull hyperactive Yang downward.
Chuan Niu Xi

Chuan Niu Xi

Cyathula roots

Dosage 12g
Temperature Neutral
Taste Bitter, Sweet
Organ Affinity Kidneys, Liver

Role in Tian Ma Gou Teng Yin

Directs Blood downward, counteracting the upward rush of Qi and Blood to the head. Also invigorates Blood and promotes urination, helping to relieve the fullness and pressure caused by Liver Yang rising.
Assistants — Supports or moderates other herbs
Zhi Zi

Zhi Zi

Cape jasmine fruits

Dosage 9g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Lungs, Sanjiao, San Jiao (Triple Burner)

Role in Tian Ma Gou Teng Yin

Clears Heat and drains Fire, especially from the Liver channel. Prevents Liver Yang from transforming into Liver Fire, addressing irritability and restlessness.
Huang Qin

Huang Qin

Baikal skullcap roots

Dosage 9g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Large Intestine, Lungs, Small Intestine, Spleen

Role in Tian Ma Gou Teng Yin

Clears Heat and dries Dampness, reinforcing Zhi Zi in clearing Liver Fire. Together they prevent the excess Yang from generating pathological Heat that would further agitate Wind.
Du Zhong

Du Zhong

Eucommia bark

Dosage 9g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Tian Ma Gou Teng Yin

Tonifies the Liver and Kidneys and strengthens sinews and bones. Addresses the root deficiency of Liver and Kidney that allows Yang to rise unchecked, treating the underlying cause while the other herbs manage the symptoms.
Sang Ji Sheng

Sang Ji Sheng

Mulberry Mistletoe

Dosage 9g
Temperature Neutral
Taste Bitter, Sweet
Organ Affinity Kidneys, Liver

Role in Tian Ma Gou Teng Yin

Nourishes the Liver and Kidneys and strengthens sinews and bones. Works alongside Du Zhong to reinforce the root, preventing further depletion of Liver-Kidney Yin that would fuel more Yang rising.
Yi Mu Cao

Yi Mu Cao

Motherwort herbs

Dosage 9g
Temperature Cool
Taste Bitter, Pungent
Organ Affinity Heart, Liver

Role in Tian Ma Gou Teng Yin

Invigorates Blood and promotes urination. Paired with Chuan Niu Xi, it helps move Blood and drain fluids, preventing Blood stasis and fluid retention that can worsen hypertension and headache.
Ye Jiao Teng

Ye Jiao Teng

Fleeceflower stems

Dosage 9g
Temperature Neutral
Taste Bitter, Sweet
Organ Affinity Heart, Liver

Role in Tian Ma Gou Teng Yin

Nourishes the Heart and calms the Spirit, addressing the insomnia and restlessness caused by Liver Yang harassing the Heart. Also nourishes Blood and opens the channels.
Fu Shen

Fu Shen

Host-wood Poria

Dosage 9g
Temperature Neutral
Taste Sweet
Organ Affinity Spleen, Heart

Role in Tian Ma Gou Teng Yin

Calms the Heart and quiets the Spirit. Works with Ye Jiao Teng to settle restlessness and improve sleep quality, a key secondary symptom of this pattern.

Why This Combination Works

How the herbs in Tian Ma Gou Teng Yin complement each other

Overall strategy

This formula addresses a condition where the Liver and Kidneys are deficient at the root, allowing Liver Yang to rise unchecked and generate internal Wind and Heat. The prescription simultaneously calms the rising Yang (the acute problem), clears the Heat it generates, nourishes the Liver and Kidneys (the underlying weakness), and settles the Spirit disturbed by the upward turbulence.

King herbs

Tian Ma (Gastrodia) and Gou Teng (Uncaria) together form the core of this formula. Tian Ma is the premier herb for extinguishing Liver Wind and calming the Liver, specifically indicated for headache, dizziness, and tremor due to internal Wind. Gou Teng is cool in nature and excels at clearing Liver Heat while extinguishing Wind. Together, they powerfully calm Liver Yang, stop Wind, and relieve the upward disturbance that causes the main symptoms.

Deputy herbs

Shi Jue Ming (Abalone Shell) is heavy, salty, and cold. Its mineral weight physically anchors the rising Yang and pulls it downward, reinforcing the King herbs' Wind-calming effect with a subduing, settling quality they lack on their own. Chuan Niu Xi (Cyathula Root) directs Blood downward away from the head, directly countering the upward rush that causes headache and flushed face. It also invigorates Blood and promotes urination, reducing vascular pressure.

Assistant herbs

Reinforcing assistants: Du Zhong and Sang Ji Sheng tonify the Liver and Kidneys, addressing the root deficiency that allows Yang to escape upward. Without these, the formula would only suppress symptoms without correcting the underlying imbalance. Restraining/clearing assistants: Zhi Zi and Huang Qin clear Heat and drain Fire from the Liver, preventing the excess Yang from transforming into pathological Fire that would further agitate Wind and disturb the Spirit. Blood-moving assistant: Yi Mu Cao invigorates Blood and promotes urination, complementing Chuan Niu Xi to ensure Blood circulates smoothly rather than accumulating in the upper body. Spirit-calming assistants: Ye Jiao Teng and Zhu Fu Shen nourish the Heart and calm the Spirit. They directly address the insomnia and restlessness that Liver Yang rising commonly causes when it harasses the Heart.

Notable synergies

Tian Ma and Gou Teng are a classic pairing: Tian Ma is neutral in temperature and excels at extinguishing Wind, while Gou Teng adds a cooling, Heat-clearing dimension. Together they calm Liver Yang from two angles. Chuan Niu Xi and Yi Mu Cao work as a pair to move Blood downward and promote urination, a dual mechanism that reduces upward pressure from both the blood vessels and fluid pathways. Du Zhong and Sang Ji Sheng together nourish the Liver-Kidney axis, ensuring the formula treats both the branch (excess Yang) and the root (Yin deficiency).

How to Prepare

Traditional preparation instructions for Tian Ma Gou Teng Yin

Place all herbs except Gou Teng (Uncaria) into the pot. Shi Jue Ming (Abalone Shell) should be decocted first for approximately 30 minutes due to its mineral nature, then add the remaining herbs (excluding Gou Teng). Bring to a boil over high heat, then reduce to a simmer for 20 to 25 minutes. Add Gou Teng during the last 5 minutes of cooking, as its active alkaloids are easily destroyed by prolonged heating.

Strain the liquid. Perform a second decoction following the same procedure. Combine the two batches of liquid and divide into 2 to 3 servings per day, taken warm.

Common Modifications

How practitioners adapt Tian Ma Gou Teng Yin for specific situations

Added
Ling Yang Jiao

1.5 - 3g, filed into powder and taken separately; powerfully subdues Liver Yang

Long Gu

15 - 30g, decocted first; heavy mineral to anchor Yang

Mu Li ke

15 - 30g, decocted first; works with Long Gu to subdue Yang and calm the Spirit

When Liver Yang rising is severe and produces intense headache and vertigo, adding these heavy, subduing substances strengthens the formula's ability to anchor Yang downward and calm internal Wind.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Tian Ma Gou Teng Yin should not be used or requires extra caution

Caution

Headache, dizziness, or tremor caused by Yin Deficiency with internal Wind (where the root problem is severe Yin depletion rather than Yang excess). This formula focuses on subduing Yang and clearing Heat, and does not sufficiently nourish Yin to address that pattern.

Avoid

Headache or dizziness caused by Liver-channel Damp-Heat or by Qi-and-Blood deficiency. The cooling, descending nature of this formula is inappropriate for deficiency patterns, and Damp-Heat requires a different treatment strategy.

Caution

Excess Liver Fire presenting with constipation, severe irritability, and red eyes. While this formula clears some Heat, it is designed for Liver Yang rising with Wind, not for blazing Liver Fire. A formula like Long Dan Xie Gan Tang may be more appropriate.

Caution

Use with caution in patients taking anticoagulant or antiplatelet medications (e.g. warfarin, aspirin). The formula contains Blood-moving herbs (Chuan Niu Xi, Yi Mu Cao) that may potentiate anticoagulant effects.

Avoid

Pregnancy. The formula contains Chuan Niu Xi (Achyranthes root) and Yi Mu Cao (Motherwort), both of which promote Blood movement and can stimulate uterine contractions.

Caution

Early stages of acute external infections (common cold, influenza). This interior-focused formula is not suited for exterior conditions and may trap pathogens inside.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The formula contains Chuan Niu Xi (Cyathula/Achyranthes root), which has a strong descending and Blood-moving action and is traditionally classified as contraindicated in pregnancy due to its ability to promote downward movement and potentially stimulate uterine contractions. Yi Mu Cao (Motherwort herb) is another ingredient of concern: it is a well-known uterine stimulant traditionally used to invigorate Blood and regulate menstruation, and is specifically contraindicated in pregnancy. The combination of these two Blood-moving herbs makes this formula unsuitable for pregnant women. Huang Qin (Scutellaria) in the formula is sometimes used to calm the fetus, but this does not outweigh the risks posed by the other ingredients.

Breastfeeding

Use with caution during breastfeeding. While there is no specific classical prohibition, several herbs in the formula warrant care. Yi Mu Cao (Motherwort) is a Blood-moving herb whose active alkaloids could potentially transfer through breast milk. Huang Qin (Scutellaria) is cold in nature and could theoretically affect the infant's digestion if transferred in significant amounts. The overall cooling and descending nature of the formula may not be ideal for postpartum women who are often in a state of Qi and Blood deficiency. Nursing mothers should consult a qualified practitioner before using this formula, and the infant should be monitored for any changes in feeding, stool, or temperament.

Children

This formula is not commonly prescribed for young children and has limited paediatric clinical data. In adolescents with early-onset hypertension showing a clear Liver Yang Rising pattern (headache, dizziness, irritability, wiry pulse), it may be considered with significant dosage reduction, typically 1/3 to 1/2 of the adult dose depending on age and body weight. The formula's cooling and descending nature should be used cautiously in children, as their constitutions tend toward Yang and their Spleen-Stomach systems are relatively delicate. The Blood-moving herbs (Chuan Niu Xi, Yi Mu Cao) should be reduced or removed in younger patients. A qualified paediatric TCM practitioner should supervise any use in children under 12.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Tian Ma Gou Teng Yin

Antihypertensive medications: This formula has demonstrated blood-pressure-lowering effects in clinical studies. When taken alongside Western antihypertensive drugs (ACE inhibitors, ARBs, calcium channel blockers, beta-blockers, or diuretics), there is a risk of additive hypotension. Blood pressure should be monitored regularly and medication doses may need adjustment to avoid excessive lowering.

Anticoagulant and antiplatelet drugs: Chuan Niu Xi (Achyranthes) and Yi Mu Cao (Motherwort) both invigorate Blood circulation and have demonstrated effects on platelet aggregation and blood viscosity. When combined with warfarin, heparin, aspirin, clopidogrel, or direct oral anticoagulants (DOACs), there is a theoretical risk of increased bleeding. Coagulation parameters (INR for warfarin users) should be monitored more closely.

Sedative and anxiolytic medications: Ye Jiao Teng (Caulis Polygoni Multiflori) and Zhu Fu Shen (Poria with pine root) have calming, spirit-settling effects. Combined with benzodiazepines, barbiturates, or other CNS depressants, there may be additive sedative effects causing excessive drowsiness.

Hepatically-metabolised drugs: Huang Qin (Scutellaria) contains baicalein and baicalin, which have been shown in pharmacological studies to affect certain cytochrome P450 enzymes. This could theoretically alter the metabolism of drugs processed through the same pathways, though clinically significant interactions have not been well documented for this formula specifically.

Usage Guidance

Practical advice for getting the most out of Tian Ma Gou Teng Yin

Best time to take

Twice daily, morning and evening, 30 minutes after meals. The decoction should be taken warm.

Typical duration

Typically prescribed for 4–8 weeks, with reassessment by a practitioner. May be taken longer for chronic hypertension management under supervision.

Dietary advice

While taking this formula, favour foods that calm the Liver and support Yin: celery, chrysanthemum tea, mung beans, leafy greens, pears, and bland grains. Avoid foods that aggravate Liver Yang and generate Heat or Wind: alcohol, coffee, spicy foods (chilli, pepper, garlic in excess), fried or greasy foods, lamb, and heavily roasted or barbecued meats. Rich, heavy foods and excessive salt should also be limited, as they can worsen hypertension and counteract the formula's descending action. Emotional agitation, anger, and excessive stress should be minimised, as these directly stir Liver Yang. Light, regular meals taken at consistent times support the formula's calming effect.

Tian Ma Gou Teng Yin originates from Zhōng Yī Nèi Kē Zá Bìng Zhèng Zhì Xīn Yì (中医内科杂病证治新义) by Hú Guāngcí (胡光慈) Modern China, 1958 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Tian Ma Gou Teng Yin and its clinical use

Source text — Hu Guangci, Zhong Yi Nei Ke Za Bing Zheng Zhi Xin Yi (中医内科杂病证治新义, 1958):

Original indication:
「治高血压头痛、眩晕、失眠。」
"Treats hypertension with headache, dizziness, and insomnia."

Author's formula commentary:
「本方为平肝降逆之剂。以天麻、钩藤、生决明平肝祛风降逆为主,辅以清降之山栀、黄芩,活血之牛膝,滋补肝肾之桑寄生、杜仲等,滋肾平肝之逆;并辅以夜交藤、朱茯神以镇静安神,缓其失眠,故为用于肝厥头痛、眩晕、失眠之良剂。」
"This formula calms the Liver and descends the counterflow. It centres on Tian Ma, Gou Teng, and Shi Jue Ming to calm the Liver, dispel Wind, and descend the counterflow. It is supported by the clearing and descending actions of Zhi Zi and Huang Qin, the Blood-invigorating action of Niu Xi, and the Liver-Kidney tonifying actions of Sang Ji Sheng and Du Zhong, which together nourish the Kidneys and calm the Liver's counterflow. Ye Jiao Teng and Zhu Fu Shen are added to sedate the spirit and ease insomnia. It is thus an excellent formula for Liver reversal headache, dizziness, and insomnia."

Historical Context

How Tian Ma Gou Teng Yin evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Tian Ma Gou Teng Yin is a relatively modern formula, created by the physician Hu Guangci (胡光慈) and published in his 1958 work Zhong Yi Nei Ke Za Bing Zheng Zhi Xin Yi (中医内科杂病证治新义, "New Significance of Patterns and Treatment in Internal Medicine Miscellaneous Diseases"). Unlike most famous Chinese formulas that trace back centuries, this formula was deliberately designed during the mid-20th century movement to integrate TCM theory with Western medical knowledge.

Hu Guangci's approach was distinctive: he was an advocate of "Chinese-Western medicine convergence" (中西医汇通), and this formula reflects that philosophy. On one hand, it follows classical TCM principles, addressing what he termed "Liver reversal" (肝厥) as the root cause of hypertensive headache and dizziness. On the other hand, he explicitly selected herbs whose pharmacological actions had been demonstrated in modern research: Huang Qin, Du Zhong, Yi Mu Cao, and Sang Ji Sheng all had documented blood-pressure-lowering effects, while Niu Xi and Yi Mu Cao have vasodilatory and diuretic properties that mirror the Western medical use of diuretics and vasodilators for hypertension.

Despite its relatively recent origin, the formula rapidly became one of the most widely prescribed formulas for hypertension in China and across East Asia. It is now a standard formula in TCM textbooks and has been the subject of extensive modern clinical research, including multiple systematic reviews and meta-analyses. It is also available as a standardised granule preparation (天麻钩藤颗粒) approved by Chinese pharmaceutical authorities.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Tian Ma Gou Teng Yin

1

Tianma Gouteng Yin as Adjunctive Treatment for Essential Hypertension: A Systematic Review of Randomized Controlled Trials (2013)

Wang J, Feng B, Yang X, et al. Evidence-Based Complementary and Alternative Medicine, 2013, Volume 2013, Article ID 706125.

This systematic review included 22 randomised controlled trials (totalling 1,808 patients) examining TGY combined with standard antihypertensive drugs versus antihypertensive drugs alone. The pooled results suggested that adding TGY to conventional treatment may further lower both systolic and diastolic blood pressure (by approximately 6.71 and 4.6 mmHg respectively) and improve clinical symptoms such as headache, dizziness, insomnia, and irritability. However, the authors noted that the overall methodological quality of the included trials was poor, and called for higher-quality research.

2

Tianma Gouteng Yin Formula for Treating Primary Hypertension: Cochrane Systematic Review (2012)

Zhang HW, Tong J, Zhou G, Jia H, Jiang JY. Cochrane Database of Systematic Reviews, 2012, Issue 6, Art. No.: CD008166.

This Cochrane review searched multiple databases in English and Chinese to find randomised or quasi-randomised controlled trials comparing TGY to placebo or no treatment for primary hypertension. No trials meeting the strict Cochrane inclusion criteria (TGY versus placebo or no treatment alone) were identified. The review concluded that the efficacy of TGY compared to placebo remains uncertain, and called for properly designed placebo-controlled trials with clinically meaningful endpoints.

3

Randomized Controlled Trials of Tianma Gouteng Decoction Combined with Nifedipine for Primary Hypertension: A Systematic Review and Meta-Analysis (2020)

Tai J, et al. Evidence-Based Complementary and Alternative Medicine, 2020, Volume 2020, Article ID 5759083.

This meta-analysis included 14 studies with 1,537 hypertensive patients and specifically examined TGY combined with the calcium channel blocker nifedipine versus nifedipine alone. The combination group showed a significantly higher total efficacy rate and greater blood pressure reductions compared to nifedipine monotherapy. No serious adverse events were reported in the included studies, though the authors again noted limitations in trial quality.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.