Herb Stem (茎 jīng)

Gou Teng

Uncaria hook vine · 钩藤

Uncaria rhynchophylla (Miq.) Miq. ex Havil. · Ramulus Uncariae cum Uncis

Also known as: Double Hook Vine, Shuāng Gōu Téng (双钩藤), Gōu Dīng (钩丁),

Images shown are for educational purposes only

Gou Teng is a gentle, cooling vine-stem herb best known for calming Liver-related headaches, dizziness, and high blood pressure. It is also widely used for childhood convulsions and seizures caused by high fever. An important note for preparation: it should not be boiled for long periods, as prolonged cooking destroys its active compounds.

TCM Properties

Temperature

Cool

Taste

Sweet (甘 gān)

Channels entered

Liver, Pericardium

Parts used

Stem (茎 jīng)

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What This Herb Does

Every herb has a specific set of actions — here's what Gou Teng does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Gou Teng is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Gou Teng performs to restore balance in the body:

How these actions work

'Extinguishes Wind and stops spasms' means Gōu Téng calms internal Wind, a TCM concept that describes involuntary movements such as tremors, convulsions, and spasms. Internal Wind in TCM most often arises from the Liver, which governs the smooth movement of tendons and sinews. Gōu Téng's cool nature and sweet taste allow it to gently settle the Liver and calm this stirring Wind. It is widely used for childhood febrile convulsions, epileptic seizures, and the convulsions of eclampsia in pregnancy. Its anti-spasmodic effect is milder than that of Líng Yáng Jiǎo (Antelope Horn) or Quán Xiē (Scorpion), so for severe convulsions it is typically combined with stronger Wind-extinguishing substances.

'Clears Heat and calms the Liver' describes how Gōu Téng's cool thermal nature helps drain mild Heat from the Liver channel. When the Liver generates excess Heat, it can cause a distending headache, red eyes, irritability, and a flushed face. Gōu Téng clears this Liver Heat, bringing relief to these symptoms. Its Heat-clearing power is moderate rather than strong, so for intense Liver Fire it is usually combined with herbs like Huáng Qín (Scutellaria) or Xià Kū Cǎo (Prunella).

'Subdues Liver Yang' refers to Gōu Téng's ability to bring down the overactive ascending force of the Liver. When Liver Yang rises excessively, it causes dizziness, vertigo, throbbing headache, tinnitus, and a sensation of pressure in the head. Gōu Téng gently settles this rising Yang. This is the action most directly linked to its modern use for high blood pressure with symptoms of dizziness and headache. It is often paired with Tiān Má (Gastrodia) or Shí Jué Míng (Abalone Shell) to strengthen this effect.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony. Gou Teng is used to help correct these specific patterns.

Why Gou Teng addresses this pattern

When Liver Yang rises excessively upward, it produces headache, dizziness, and irritability. Gōu Téng enters the Liver channel with a cool, sweet nature that directly subdues this excessive rising Yang. Its gentle descending action settles the hyperactive Liver, relieving the upward pressure that causes head symptoms. This is the pattern most strongly associated with Gōu Téng, and it forms the rationale for its use in hypertension formulas like Tiān Má Gōu Téng Yǐn.

A practitioner would look for one or more of these signs

Dizziness

Especially with a sensation of upward pressure

Headaches

Distending or throbbing headache, often at the temples or vertex

Hypertension

High blood pressure with dizziness and facial flushing

Commonly Used For

These are conditions where Gou Teng is frequently used — but only when they arise from the specific patterns it addresses, not in all cases

TCM Interpretation

In TCM, high blood pressure is not treated as a single disease but is understood through the patterns that produce it. The most common pattern is Liver Yang Rising, where insufficient Yin (the cooling, anchoring force) fails to restrain the Liver's Yang (its active, ascending force). The Yang rises unchecked to the head, producing dizziness, throbbing headache, and facial flushing. The underlying root is often Liver-Kidney Yin Deficiency, but the urgent symptoms are caused by the Yang excess above. Over time, if not addressed, this rising Yang can generate Wind and lead to more serious events like stroke.

Why Gou Teng Helps

Gōu Téng directly addresses the core mechanism of Liver Yang Rising hypertension. Its cool thermal nature counteracts the Heat that accompanies rising Yang, while its Liver channel affinity ensures it acts precisely where the problem originates. It gently descends the Yang force back downward, relieving the upward pressure that causes headache and dizziness. Modern pharmacological research has confirmed that its alkaloids (rhynchophylline and isorhynchophylline) produce vasodilation through calcium channel modulation and nitric oxide release, providing a biomedical basis for the blood pressure lowering observed clinically. Importantly, Gōu Téng's action is mild and gradual, making it suitable for sustained use in formulas rather than as an emergency intervention.

Also commonly used for

Headaches

Liver-related headache with distension and throbbing

Dizziness

Vertigo and dizziness from Liver Yang or Liver Wind

Eclampsia

Pregnancy-related eclampsia with convulsions

Epilepsy

As part of formulas for epileptic seizures

Insomnia

When caused by Liver Yang disturbing the Heart-mind

Tinnitus

Ringing in the ears from Liver Yang Rising

Stroke

Acute cerebrovascular events from Liver Wind and Yang Rising

Herb Properties

Every herb has an inherent temperature, taste, and affinity for specific channels — these properties determine how it interacts with the body

Temperature

Cool

Taste

Sweet (甘 gān)

Channels Entered

Liver Pericardium

Parts Used

Stem (茎 jīng)

Dosage & Preparation

These are general dosage guidelines for Gou Teng — always follow your practitioner's recommendation, as dosages vary based on the formula and your individual condition

Standard dosage

3-12g

Maximum dosage

Up to 30g in acute hypertension or severe Liver Yang rising, under practitioner supervision. Clinical reports of treating hypertension used doses of 30-60g (2 liang) with good results, though such high doses require careful monitoring.

Dosage notes

Lower doses (3-9g) are appropriate for mild headaches, dizziness, and as part of multi-herb formulas. Higher doses (12-30g) are used for acute hypertension, severe Liver Yang headaches, and high febrile convulsions. Clinical experience with hypertension suggests that doses below 9-15g are often insufficient for meaningful blood pressure reduction, while 30g or more may be needed for significant effect. Excessive prolonged use in patients with Spleen-Stomach deficiency-cold may cause digestive discomfort. The decoction must not be boiled for too long: the active alkaloids decompose after approximately 20 minutes of boiling, significantly reducing therapeutic effect.

Preparation

Must be added near the end of decoction (后下, hou xia). Add Gou Teng during the last 5 to 15 minutes of boiling only. Prolonged boiling (over 20 minutes) destroys the active indole alkaloids (primarily rhynchophylline and isorhynchophylline), significantly reducing both the sedative and blood pressure-lowering effects. This is one of the most important preparation instructions in TCM herbology for this herb.

Common Herb Pairs

These ingredients are traditionally combined with Gou Teng for enhanced therapeutic effect

Tian Ma
Tian Ma Tiān Má 9g : Gōu Téng 12g

Tiān Má and Gōu Téng are the definitive herb pair for calming the Liver and extinguishing Wind. Tiān Má excels at subduing Liver Yang and stopping dizziness, while Gōu Téng contributes cooling Heat-clearing and gentle anti-spasmodic action. Together they address both the Yang rising and the Wind it generates, providing a comprehensive approach to headache, vertigo, and tremors from Liver imbalance.

When to use: Liver Yang Rising or Liver Wind causing dizziness, vertigo, headache, tremors, or hypertension. This is the core herb pair of Tiān Má Gōu Téng Yǐn.

Shi Jue Ming
Shi Jue Ming Shí Jué Míng 15-30g : Gōu Téng 9-12g

Shí Jué Míng (Abalone Shell) is heavy and sinking, powerfully anchoring Liver Yang downward and clearing Liver Heat. Gōu Téng complements this by extinguishing Wind and relaxing the sinews. Together, one anchors from below while the other calms from within, greatly strengthening the combined ability to subdue Liver Yang.

When to use: Liver Yang Rising with pronounced dizziness, distending headache, and red eyes. Commonly seen in hypertension presentations.

Ju Hua
Ju Hua 1:1 (9g each)

Jú Huā (Chrysanthemum) clears Liver Heat, brightens the eyes, and disperses Wind-Heat from the head. Paired with Gōu Téng, which subdues Yang and calms Wind, the combination effectively addresses headache with dizziness from Liver Yang Rising or Liver Fire, especially when accompanied by red, dry eyes.

When to use: Liver Yang or Liver Fire producing headache, dizziness, and eye symptoms such as blurred vision or red eyes.

Ling Yang Jiao
Ling Yang Jiao Líng Yáng Jiǎo 4.5g (decocted first) : Gōu Téng 9g (added near end of decoction)

Líng Yáng Jiǎo (Antelope Horn) is one of the most powerful substances for cooling the Liver and extinguishing Wind. When combined with Gōu Téng, which is milder but shares the same channel affinity and Wind-calming action, the pair creates a potent anti-convulsive combination that is the core of Líng Jiǎo Gōu Téng Tāng. The two reinforce each other for clearing Heat, calming Wind, and stopping spasms.

When to use: High fever with convulsions, eclampsia, or severe Liver Wind from extreme Heat. This is the core pair of the Líng Jiǎo Gōu Téng Tāng formula.

Key Formulas

These well-known formulas feature Gou Teng in a prominent role

Tian Ma Gou Teng Yin 天麻鉤藤飲 King

This is the definitive formula for Gōu Téng's Liver Yang-subduing action. Gōu Téng serves as co-King alongside Tiān Má, at 12g, directly showcasing its core ability to calm the Liver, subdue Yang, and clear Heat. The formula is the most widely used prescription for hypertension with Liver Yang Rising and is the first formula that comes to mind when practitioners think of Gōu Téng.

Ling Jiao Gou Teng Tang 羚角鉤藤湯 King

This formula showcases Gōu Téng's Wind-extinguishing and anti-spasmodic action in acute, Heat-driven convulsions. Gōu Téng serves as co-King with Líng Yáng Jiǎo, where it contributes its cooling, Wind-calming property to treat high fever with convulsions or eclampsia. It is the representative formula for Gōu Téng's role in the treatment of Liver Wind from extreme Heat.

Comparable Ingredients

These ingredients have overlapping uses — here's how to tell them apart

Tian Ma
Gou Teng vs Tian Ma

Both Tiān Má and Gōu Téng calm the Liver and extinguish Wind, and they are frequently used together. The key difference: Tiān Má is neutral in temperature and excels at stopping dizziness and vertigo regardless of whether Heat is present. Gōu Téng is cool, so it additionally clears Liver Heat, making it more suitable when Heat signs (red face, irritability, yellow tongue coating) accompany the dizziness. For patterns without clear Heat, Tiān Má can be used alone. When Heat is prominent, Gōu Téng is preferred or the two are combined.

Ling Yang Jiao
Gou Teng vs Ling Yang Jiao

Both cool the Liver and extinguish Wind, but Líng Yáng Jiǎo (Antelope Horn) is far more powerful in clearing intense Heat and stopping severe convulsions. It is used for critical, acute conditions like high fever with loss of consciousness and violent spasms. Gōu Téng is much milder, with a gentler cooling action, and is better suited for chronic or moderate conditions like Liver Yang headaches and hypertension. Gōu Téng is also far more accessible and affordable.

Xia Ku Cao
Gou Teng vs Xia Ku Cao

Both clear Liver Heat and are used for Liver-related headaches and hypertension. Xià Kū Cǎo (Prunella) is bitter and acrid, giving it a stronger Heat-clearing and nodule-dispersing action, so it is preferred when there are firm lumps (like thyroid nodules or lymphadenopathy) or when Liver Fire is intense. Gōu Téng, being sweet and cool, has the additional ability to extinguish Wind and stop spasms, which Xià Kū Cǎo does not possess. Choose Gōu Téng when dizziness, tremor, or convulsions are present alongside the headache.

Common Substitutes & Adulterants

Related species and common adulterations to be aware of when sourcing Gou Teng

The Chinese Pharmacopoeia accepts five Uncaria species as legitimate sources, but quality varies significantly between them. The most prized are U. rhynchophylla and U. sinensis (华钩藤), which have the highest alkaloid content. Common quality issues include: (1) Mixing of old hookless stems (老枝) with the hooked segments; old stems over 0.5 cm diameter have very poor therapeutic activity, especially for blood pressure-lowering effects. (2) Large-leaf Uncaria (大叶钩藤, U. macrophylla) and hairy Uncaria (毛钩藤, U. hirsuta) are accepted but produce yellowish-brown rather than purplish-red material after processing, and may differ in alkaloid profiles. (3) Stems of other climbing plants may occasionally be mixed in. The key authentication feature is the presence of characteristic paired hooks at the nodes, which is unique to Uncaria species.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herb.

Toxicity Classification

Classical Chinese pharmacopoeia toxicity rating for Gou Teng

Non-toxic

Gou Teng is classified as non-toxic in traditional and modern sources. The Ming Yi Bie Lu explicitly states it is "non-toxic" (无毒). Animal toxicology studies show a wide safety margin: the LD50 of the decoction in mice by intraperitoneal injection is approximately 29 g/kg, and the oral LD50 of total alkaloids is about 515 mg/kg, both far exceeding clinical doses. Sub-acute toxicity testing in rabbits at 2.5 times the therapeutic dose for 10 days showed no signs of toxicity. However, prolonged high-dose administration of the isolated total alkaloids (100 mg/kg daily for two months) in young rats caused pathological changes in the heart, liver, and kidneys. At therapeutic doses, no significant organ damage has been observed. The key alkaloids (rhynchophylline, isorhynchophylline) are the primary active and potentially concerning components at extreme doses.

Contraindications

Situations where Gou Teng should not be used or requires extra caution

Caution

People with deficiency-cold constitutions or those without internal Heat or Liver Yang rising should avoid Gou Teng. As a cool-natured herb that clears Heat and subdues Liver Yang, it can worsen cold-type patterns and further deplete Yang Qi.

Caution

Low blood pressure (hypotension). Gou Teng has well-documented blood pressure-lowering effects through vasodilation and central nervous system mechanisms. It may cause excessive drops in blood pressure in those already prone to low readings.

Caution

Concurrent use of strong sedative or antihypertensive medications without dose adjustment. The herb's sedative and hypotensive properties may compound these drug effects, leading to excessive drowsiness or dangerously low blood pressure.

Caution

Active hemorrhage or bleeding disorders. Animal studies show that rhynchophylline (the main alkaloid) can inhibit platelet aggregation and has antithrombotic properties, which may worsen bleeding tendencies.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Gou Teng has a complex relationship with pregnancy in TCM. On one hand, it is traditionally used to treat pregnancy eclampsia (子痫, zi xian), a dangerous condition of convulsions and high blood pressure during pregnancy, as seen in the classical formula Gou Teng Tang from the Tai Chan Xin Fa. On the other hand, animal studies show that rhynchophylline can stimulate uterine smooth muscle in rats. Because of its cool nature and blood pressure-lowering properties, it should only be used during pregnancy under the guidance of a qualified practitioner, for specific indications such as eclampsia, and not as a casual supplement. Modern sources list pregnant women as a caution group.

Breastfeeding

There is limited specific data on Gou Teng's safety during breastfeeding. While the herb is classified as non-toxic and has a long history of safe use in paediatric practice, the alkaloid components (rhynchophylline, isorhynchophylline) could theoretically pass into breast milk. The sedative and blood pressure-lowering effects are a theoretical concern for nursing infants. Use during breastfeeding should be under practitioner supervision, at standard doses, and for limited duration.

Children

Gou Teng has an exceptionally long history as a paediatric herb; for the first thousand years of its recorded use, it was considered exclusively a children's medicine. It is gentle and well-tolerated, commonly used for childhood febrile convulsions, night crying due to Heat, and fright syndromes. Dosage should be adjusted by age: approximately one-third of the adult dose for infants, and one-half to two-thirds for children aged 3 to 12. As with adult use, it must be added late in the decoction (last 5 to 15 minutes) to preserve its active alkaloids.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Gou Teng

Antihypertensive medications: Gou Teng has well-documented blood pressure-lowering effects through vasodilation and reduced peripheral resistance. Combined use with pharmaceutical antihypertensives (ACE inhibitors, ARBs, calcium channel blockers, beta-blockers) may result in additive hypotensive effects and an excessive drop in blood pressure. Blood pressure should be monitored closely.

Sedatives and CNS depressants: The herb has demonstrated sedative effects in animal models, reducing cortical excitability. Combined use with benzodiazepines, barbiturates, or other sedative-hypnotic drugs may potentiate drowsiness or over-sedation.

CYP3A4-metabolised drugs: A recent pharmacokinetic review noted that the alkaloids of Gou Teng undergo significant first-pass metabolism via CYP3A4. There is a theoretical potential for interaction with drugs that are also substrates or inhibitors of this enzyme pathway, though this has not been confirmed clinically.

Anticoagulants and antiplatelet agents: Rhynchophylline has shown significant platelet aggregation inhibition and antithrombotic effects in animal studies. Caution is warranted when combining with warfarin, heparin, aspirin, or clopidogrel.

Dietary Advice

Foods and dietary considerations when taking Gou Teng

Avoid excessive alcohol consumption while taking Gou Teng, as both have blood pressure-lowering and sedative effects that may compound each other. Avoid excessively greasy, spicy, or Heat-producing foods (deep-fried foods, chilli, lamb), as these may aggravate the Liver Yang or Liver Fire conditions that Gou Teng is typically prescribed to treat. A diet emphasizing cooling vegetables, leafy greens, and light, easily digested foods supports the herb's therapeutic direction.

Botanical Description

Physical characteristics and morphology of the Gou Teng source plant

Gou Teng comes from several species of Uncaria, a genus of woody climbing vines (lianas) in the Rubiaceae (coffee/madder) family. The primary species is Uncaria rhynchophylla (Miq.) Miq. ex Havil., with U. sinensis, U. macrophylla, U. hirsuta, and U. sessilifructus also accepted as official sources in the Chinese Pharmacopoeia.

Uncaria rhynchophylla is a vigorous climbing vine reaching up to 10 metres in length. Its young stems are distinctly square (four-angled) and smooth. The leaves are opposite, papery, elliptical to oblong, 5 to 12 cm long, with pointed tips. The most distinctive feature is the pair of curved, hook-shaped structures at each leaf node (modified sterile flower stalks), which the plant uses to cling to supporting trees. These hooks, typically 1 to 2 cm long, curve downward like a fishhook and give the herb both its Chinese name ("hook vine") and its medicinal identity. The small yellowish flowers appear in spherical heads from June to August. The plant grows naturally in moist, shaded forests, forest margins, and shrubby thickets in subtropical and tropical regions of East and Southeast Asia.

Sourcing & Harvesting

Where Gou Teng is sourced, when it's harvested or collected, and how to assess quality

Harvesting season

Autumn and winter, when the hooked stem branches are cut, leaves removed, and the material is sun-dried.

Primary growing regions

Gou Teng is primarily produced in the southern Chinese provinces. The highest quality habitat (high suitability zones) includes Guangxi, Guizhou, Hunan, and Fujian provinces. Guangxi is particularly notable as a major production and cultivation area. Additional producing regions include Guangdong, Hubei, Jiangxi, Sichuan, Zhejiang, and Yunnan. Guizhou province (especially Jianhe County) has become a major centre for cultivated Gou Teng. The plant also occurs naturally in Japan and Vietnam.

Quality indicators

Good quality Gou Teng consists of stem segments 2 to 3 cm long, 0.2 to 0.5 cm in diameter, with intact, well-formed double hooks at the nodes (both hooks present and curving downward). The outer surface should be reddish-brown to purplish-red, smooth, and slightly glossy. The texture should be firm and resilient when broken, with a yellowish-brown cross-section showing fibrous bark and a yellowish-white or hollow pith. High hook content (hooks present at most nodes) is the most important quality indicator. The herb should be free of thick old stems (over 6 mm diameter), broken or missing hooks, insect damage, and mould. It should have no particular smell and a bland taste. Pieces that are yellowish-green with visible lenticel spots are from different species and considered lower grade.

Classical Texts

Key passages from the classical Chinese medical texts that describe Gou Teng and its therapeutic uses

《本草经集注》 (Collected Commentaries on the Classic of Materia Medica) — Tao Hongjing

Original: 微寒,无毒。主治小儿寒热,十二惊痫。

Translation: Slightly cold, non-toxic. Treats children's alternating chills and fever, and the twelve types of childhood convulsions.

《本草纲目》 (Compendium of Materia Medica) — Li Shizhen

Original: 钩藤,手、足厥阴药也。足厥阴主风,手厥阴主火,惊癎眩运,皆肝风相火之病,钩藤通心包于肝木,风静火熄,则诸症自除。

Translation: Gou Teng is a herb of the Hand and Foot Jueyin channels. The Foot Jueyin (Liver) governs Wind, and the Hand Jueyin (Pericardium) governs Fire. Convulsions, epilepsy, and dizziness are all diseases of Liver Wind and Ministerial Fire. Gou Teng connects the Pericardium to the Liver; when Wind is calmed and Fire is extinguished, all symptoms resolve naturally.

《本草纲目》 (Compendium of Materia Medica) — Li Shizhen

Original: 状如葡萄藤而有钩,紫色。古方多用皮,后世多用钩,取其力锐耳。

Translation: It resembles a grape vine but has hooks, and is purplish in colour. Ancient formulas mostly used the bark, while later generations favoured the hooks, seeking their sharper therapeutic effect.

《药性论》 (Treatise on the Properties of Medicines)

Original: 主小儿惊啼,瘲热壅。

Translation: Treats children's frightened crying, convulsions, and Heat congestion.

Historical Context

The history and evolution of Gou Teng's use in Chinese medicine over the centuries

Gou Teng was first recorded in the Wei-Jin period text Ming Yi Bie Lu (名医别录, Supplementary Records of Famous Physicians), making it one of the older herbs in the Chinese materia medica with over 1,500 years of documented use. The Xin Xiu Ben Cao (Newly Revised Materia Medica, Tang Dynasty) noted that it was produced in Liangzhou (modern Hanzhong, Shaanxi) and described its slender leaves, long stems, and hook-like thorns at the nodes. Tao Hongjing of the Liang Dynasty wrote that it was produced in Jianping (modern Wushan, Sichuan/Enshi, Hubei) and remarked that it "only treats children and does not enter other formulas" (惟治小儿,不入余方), reflecting its early reputation as a paediatric specialist herb.

The name "Gou Teng" (钩藤) literally means "hook vine," describing the distinctive curved hooks on the stems. Li Shizhen in the Ben Cao Gang Mu (明, Ming Dynasty) explained: "its thorns are curved like a fishhook, hence the name" (其刺曲如钓钩,故名). He also noted the important shift from ancient practice of using the bark to later use of the hooks themselves, "seeking their sharper therapeutic power." By the Qing Dynasty, the great physician Ye Tianshi (叶天士) greatly expanded its clinical application beyond paediatrics, using Gou Teng skillfully in formulas for Liver Yang headaches, phlegm-dizziness, and Liver Fire disturbing the Luo-collaterals in adults. This evolution from a children's-only remedy to a versatile Liver-calming herb represents one of the most significant expansions of a single herb's clinical range in TCM history.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Gou Teng

1

Ethnopharmacological Review of Uncaria rhynchophylla: Traditional Uses, Phytochemistry, and Pharmacology (Systematic Narrative Review, 2026)

Authors not fully specified, Frontiers in Pharmacology, 2026, doi pending

This comprehensive review analysed 78 studies (2000-2025) and found that the herb's main active compounds are monoterpenoid indole alkaloids. Its blood pressure-lowering effects work through calcium channel blocking and nitric oxide-mediated blood vessel relaxation. Neuroprotective effects were confirmed across multiple models. The review noted poor oral bioavailability due to first-pass liver metabolism (CYP3A4) and called for larger clinical trials.

Link
2

Uncaria rhynchophylla and its Major Constituents on Central Nervous System: A Review on Their Pharmacological Actions (Review, 2020)

Zhang C et al., Current Vascular Pharmacology, 2020, 18(4), 346-356

This review summarised the central nervous system effects of Gou Teng and its alkaloids (rhynchophylline, isorhynchophylline, corynoxeine, hirsutine, hirsuteine). The alkaloids showed sedative, anticonvulsant, and neuroprotective properties across multiple animal models. Rhynchophylline in particular showed strong protection against NMDA-mediated excitotoxicity. The authors concluded the herb has multiple beneficial pharmacological effects on the central nervous system.

PubMed
3

Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer's Disease From the Perspective of Pathophysiological Processes (Network Pharmacology Study, 2022)

Zhao Y et al., Frontiers in Pharmacology, 2022, 12, 806984

Using network pharmacology and molecular docking, researchers identified 10 alkaloids from Gou Teng corresponding to 127 targets related to amyloid-beta and tau pathology in Alzheimer's disease. The alkaloids angustoline, angustidine, corynoxine, and isocorynoxeine were identified as the most promising candidates for Alzheimer's treatment. The study found that the alkaloids are brain-permeable and may reduce amyloid-induced cell death and tau hyperphosphorylation.

Link

Research on individual TCM herbs is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.