Zhen Gan Xi Feng Tang

Sedate the Liver and Extinguish Wind Decoction · 鎮肝熄風湯

Also known as: Zhen Gan Xi Feng Tang, Settle the Liver and Extinguish Wind Decoction, Pacifying the Liver and Extinguishing Wind Decoction

A classical formula designed to calm the Liver and stop internally generated Wind, used for conditions related to high blood pressure, dizziness, headache, and stroke risk caused by an overactive Liver and depleted Kidney Yin. It works by anchoring rising Qi and Blood back downward, calming the Liver, nourishing Yin, and preventing the chaotic upward rush that can lead to serious neurological symptoms.

Origin Yi Xue Zhong Zhong Can Xi Lu (医学衷中参西录, Records of Medicine with Reference to East and West) by Zhang Xichun — Late Qīng dynasty to early Republican era, first published 1918 CE
Composition 12 herbs
Chuan Niu Xi
King
Chuan Niu Xi
Dai Zhe Shi
Deputy
Dai Zhe Shi
Long Gu
Deputy
Long Gu
Mu Li
Deputy
Mu Li
Gui Ban
Deputy
Gui Ban
Bai Shao
Deputy
Bai Shao
Xuan Shen
Assistant
Xuan Shen
Tian Men Dong
Assistant
Tian Men Dong
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Zhen Gan Xi Feng Tang is designed to correct these specific patterns.

Why Zhen Gan Xi Feng Tang addresses this pattern

When Liver and Kidney Yin are depleted over time, Yin can no longer anchor Yang, and Liver Yang rises unchecked to the upper body. This produces dizziness, headache with a sensation of heat, tinnitus, eye distension, facial flushing, and irritability. The pulse is characteristically wiry, long, and forceful. Zhen Gan Xi Feng Tang directly addresses this by using Niu Xi and Dai Zhe Shi to strongly direct the rebellious Qi and Blood back downward, while Long Gu, Mu Li, Gui Ban, and Bai Shao anchor the floating Yang and nourish the depleted Yin at its root. The Yin-nourishing herbs (Xuan Shen, Tian Dong, Gui Ban, Bai Shao) replenish the Kidney Water needed to keep Liver Wood in check, treating the underlying cause.

A practitioner would look for one or more of these signs

Dizziness

Persistent or severe dizziness and vertigo

Headaches

Headache with sensation of heat or distension in the head

Tinnitus

Ringing in the ears

Facial Flushing

Face red as if intoxicated

Irritability

Restlessness and irritability with heat sensation in the chest

Hypertension

High blood pressure with a wiry, forceful pulse

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Zhen Gan Xi Feng Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, what Western medicine calls high blood pressure most commonly corresponds to Liver Yang Rising from an underlying Liver and Kidney Yin Deficiency. The Liver governs the smooth flow of Qi throughout the body, and the Kidneys store the body's foundational Yin. When Kidney Yin becomes depleted (through aging, chronic stress, overwork, or constitutional factors), it can no longer anchor and nourish the Liver. The Liver's Yang then rises unchecked, dragging Qi and Blood upward to the head. This produces the characteristic cluster of symptoms: dizziness, throbbing headache, facial flushing, tinnitus, and irritability. The wiry, long, forceful pulse that Zhang Xichun identified as the key diagnostic sign directly reflects this pattern of excessive upward force.

Why Zhen Gan Xi Feng Tang Helps

Zhen Gan Xi Feng Tang addresses hypertension through a multi-layered strategy. Niu Xi and Dai Zhe Shi at heavy dosages (30g each) powerfully redirect the upward-surging Qi and Blood back downward, which can produce relatively rapid relief of acute symptoms. Long Gu, Mu Li, and Gui Ban anchor the floating Yang and calm the spirit. Gui Ban, Bai Shao, Xuan Shen, and Tian Dong replenish the depleted Kidney and Liver Yin, addressing the root imbalance that drives the elevated blood pressure over time. Modern research has demonstrated that this formula can reduce blood pressure in spontaneously hypertensive rats and improve vascular health, supporting its traditional use.

Also commonly used for

Cerebral Hemorrhage

Zhang Xichun's original indication of 'brain congestion'

Headaches

Vascular headache or hypertensive headache with Liver Yang rising signs

Parkinson's Disease

Tremor and rigidity fitting the Liver Wind pattern

Menopausal Symptoms

Hot flashes, dizziness, irritability with Liver-Kidney Yin deficiency and Yang rising

Tinnitus

Ringing ears from Liver Yang rising

Insomnia

Restless insomnia due to Liver Yang disturbing the spirit

Epilepsy

Seizures fitting the Liver Wind pattern

Facial Paralysis

Bell's palsy or facial spasm from internal Wind

Tourette Syndrome

Childhood tic disorders fitting the Liver Wind pattern

What This Formula Does

Every TCM formula has a specific set of actions — here's what Zhen Gan Xi Feng Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Zhen Gan Xi Feng Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Zhen Gan Xi Feng Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Zhen Gan Xi Feng Tang works at the root level.

The core disease mechanism addressed by Zhen Gan Xi Feng Tang is internal Wind generated by Liver Yang rising, rooted in Liver and Kidney Yin deficiency. In TCM theory, the Liver is a Wood-phase organ that stores Blood and governs the smooth flow of Qi. When Kidney and Liver Yin become depleted (from aging, chronic illness, emotional strain, or overwork), they can no longer anchor the Liver's Yang aspect. This unanchored Yang rises unchecked, and when it intensifies further, it transforms into internal Wind.

Zhang Xichun explains that when Liver Wood's fire blazes, the Lung's descending function fails, the Kidney's anchoring function weakens, and the Qi of the Penetrating Vessel (Chong Mai) and Stomach also rebel upward. All the organ systems' Qi moves excessively upward, carrying Blood up to the brain. The brain's blood vessels become overfilled, affecting the nervous system. In mild cases, this produces headache with a sensation of heat in the head, dizziness, eye distension, ear ringing, a flushed face, and irritability. In severe cases, the chaotic upward surging of Qi and Blood leads to sudden collapse, loss of consciousness, and what he terms "internal Wind-stroke" (equivalent to what he recognized as cerebral hemorrhage or severe hypertension).

Crucially, this is not Wind coming from outside the body. The Wind is generated internally by the body's own imbalance. Zhang Xichun specifically warns that confusing this with externally-contracted Wind and using dispersing herbs would be disastrous, as such herbs would drive more Blood upward to the brain. The underlying pattern is one of excess above (Yang and Wind surging to the head) combined with deficiency below (depleted Yin failing to anchor), with the acute excess being the dominant clinical concern.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly salty and bitter with some sweet notes. The salty quality (from shells and minerals) softens hardness and anchors the Yang downward, while the bitter quality (from Xuan Shen, Chuan Lian Zi, Yin Chen) clears Heat and descends. The sweet taste of Gan Cao and Mai Ya harmonizes and protects the Stomach.

Channels Entered

Liver Kidney Stomach Lung Chong Mai (冲脉) Penetrating Vessel

Ingredients

12 herbs

The herbs that make up Zhen Gan Xi Feng Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Chuan Niu Xi

Chuan Niu Xi

Cyathula root

Dosage 30g
Temperature Neutral
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Liver, Kidneys

Role in Zhen Gan Xi Feng Tang

Used at heavy dosage to powerfully direct Blood downward, counteracting the pathological upward rush of Qi and Blood to the head. Also nourishes the Liver and Kidneys, addressing the root deficiency.
Deputies — Assists and enhances the King
Dai Zhe Shi

Dai Zhe Shi

Hematite

Dosage 30g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Liver, Heart, Stomach, Pericardium
Preparation Grind finely (轧细) before decocting

Role in Zhen Gan Xi Feng Tang

Heavy mineral that strongly directs Qi downward, sedates the Liver, anchors rising Yang, descends Stomach Qi, and pacifies rebellious Qi in the Penetrating Vessel (Chong Mai). Works with Niu Xi to urgently pull Qi and Blood downward.
Long Gu

Long Gu

Dragon bone (fossilized bone)

Dosage 15g
Temperature Neutral
Taste Sweet (甘 gān), Astringent (涩 sè)
Organ Affinity Heart, Liver, Kidneys
Preparation Crush before decocting; decoct first 20 minutes

Role in Zhen Gan Xi Feng Tang

Settles and calms the spirit, anchors ascending Liver Yang, and restrains internal Wind. Its heavy, astringent nature helps contain the upward surge of Yang.
Mu Li

Mu Li

Oyster shell

Dosage 15g
Temperature Slightly Cool
Taste Salty (咸 xián), Astringent (涩 sè)
Organ Affinity Liver, Gallbladder, Kidneys
Preparation Crush before decocting; decoct first 20 minutes

Role in Zhen Gan Xi Feng Tang

Calms and anchors the spirit, subdues rising Yang, nourishes Yin, and softens hardness. Paired with Long Gu to powerfully subdue Liver Yang and restrain Wind.
Gui Ban

Gui Ban

Tortoise plastron

Dosage 15g
Temperature Cold
Taste Salty (咸 xián), Sweet (甘 gān)
Organ Affinity Liver, Heart, Kidneys
Preparation Crush before decocting; decoct first 20 minutes

Role in Zhen Gan Xi Feng Tang

Nourishes Yin, subdues Yang, and strengthens the Kidneys. As a shell substance, it anchors floating Yang while simultaneously enriching Kidney Yin to address the root of the condition.
Bai Shao

Bai Shao

White peony root

Dosage 15g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen

Role in Zhen Gan Xi Feng Tang

Nourishes Liver Blood and Yin, softens and restrains the Liver, alleviates pain, and helps calm Liver Yang. Its sour, astringent quality counteracts the Liver's tendency to overact.
Assistants — Supports or moderates other herbs
Xuan Shen

Xuan Shen

Ningpo figwort root

Dosage 15g
Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Lungs, Stomach, Kidneys

Role in Zhen Gan Xi Feng Tang

Nourishes Kidney Yin, clears deficiency Heat, and cools the Blood. Works with Tian Dong to enrich Yin at the root level, helping Kidney Water control Liver Wood.
Tian Men Dong

Tian Men Dong

Asparagus tuber

Dosage 15g
Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Kidneys

Role in Zhen Gan Xi Feng Tang

Nourishes Kidney and Lung Yin, clears Lung Heat. Zhang Xichun specifically noted that when the Lung's descending function is restored, it naturally restrains the Liver. Supports the Kidney Yin foundation.
Yin Chen

Yin Chen

Capillary wormwood

Dosage 6g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Liver, Gallbladder

Role in Zhen Gan Xi Feng Tang

Clears Liver Heat and gently soothes Liver constraint. Zhang Xichun described it as resonating with the Liver's spring-like nature, allowing the formula to subdue the Liver without suppressing its natural tendency toward free-flowing movement.
Chuan Lian Zi

Chuan Lian Zi

Szechwan chinaberry fruit

Dosage 6g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Liver, Small Intestine, Urinary Bladder
Preparation Crush before decocting

Role in Zhen Gan Xi Feng Tang

Directs Liver Qi downward and drains Liver Heat. Zhang Xichun noted it can curb the Liver's rebellious counterforce when the Liver resists being suppressed by heavy sedating herbs.
Mai Ya

Mai Ya

Barley sprout (Malt)

Dosage 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Liver

Role in Zhen Gan Xi Feng Tang

Gently soothes and smooths Liver Qi, prevents the heavy sedating herbs from causing Liver Qi stagnation. As a sprouting grain, it harmonizes with the Liver's nature of growth and spreading. Also protects the Stomach from the heavy mineral ingredients.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 4.5g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Zhen Gan Xi Feng Tang

Harmonizes the actions of all the other herbs, protects the Stomach from damage by the heavy mineral and shell substances, and supports the Spleen's digestive function together with Mai Ya.

Why This Combination Works

How the herbs in Zhen Gan Xi Feng Tang complement each other

Overall strategy

This formula addresses a condition where the Liver and Kidney Yin are depleted, causing Liver Yang to rise unchecked and generate internal Wind. The resulting chaotic upward surge of Qi and Blood toward the head produces dizziness, headache, flushed face, and in severe cases, stroke-like collapse. The prescription combines heavy downward-directing and Yang-anchoring substances with Yin-nourishing herbs and gentle Liver-soothing agents to both quell the acute crisis (the standard) and address the underlying deficiency (the root).

King herbs

Huai Niu Xi is the sole King herb, used at the highest dosage (30g). It enters the Liver and Kidney channels and has a strong downward-directing nature, making it ideal for pulling the rebelliously ascending Blood back downward. Zhang Xichun called it the primary herb for treating the acute manifestation. It also nourishes the Liver and Kidneys, contributing to the root treatment.

Deputy herbs

Dai Zhe Shi (30g) partners with Niu Xi as a heavy mineral that powerfully descends Qi and sedates the Liver, also calming rebellious Stomach and Penetrating Vessel Qi. Long Gu and Mu Li (each 15g) work as a classic pair to anchor floating Yang, calm the spirit, and restrain internal Wind. Gui Ban (15g) enriches Kidney Yin while subduing Yang from below, addressing the root Yin deficiency. Bai Shao (15g) nourishes Liver Blood, softens the Liver's rigid nature, and assists the sedating action from a Yin-nourishing angle.

Assistant herbs

Xuan Shen and Tian Dong (each 15g) are reinforcing assistants that nourish Kidney and Lung Yin. Zhang Xichun specifically noted that restoring the Lung's descending function helps naturally restrain the Liver, leveraging the Metal-controls-Wood relationship in Five Phase theory. Together with Gui Ban and Bai Shao, they enrich the depleted Yin that is the root cause of the Yang uprising.

Yin Chen, Chuan Lian Zi, and Sheng Mai Ya (each 6g) are restraining assistants added to prevent an important side effect: because the Liver is a rigid organ that hates being suppressed, using only heavy sedating herbs can provoke a rebound worsening. Zhang Xichun discovered this through clinical experience and added these three herbs to gently soothe and course Liver Qi, allowing the Liver to be subdued without losing its natural free-flowing character. Yin Chen clears Liver Heat while resonating with spring-like Liver Qi. Chuan Lian Zi directs Liver Qi downward and curbs its rebellious force. Mai Ya, as a sprouting grain, harmonizes with the Liver's growth-oriented nature.

Envoy herbs

Gan Cao (4.5g) harmonizes all the other ingredients and, together with Mai Ya, protects the Stomach and Spleen from irritation by the heavy mineral and shell substances in the formula.

Notable synergies

The Niu Xi and Dai Zhe Shi pairing creates a powerful downward-directing force that neither achieves alone: Niu Xi works through the Blood level while Dai Zhe Shi works through the Qi level, together pulling both Qi and Blood downward. The Long Gu and Mu Li pairing is a classical combination for anchoring Yang and calming the spirit, with their combined sinking and astringent qualities far exceeding their individual effects. The trio of Yin Chen, Chuan Lian Zi, and Mai Ya represents Zhang Xichun's unique clinical insight: they prevent the formula's strong sedating action from provoking a Liver backlash, a subtlety that distinguishes this formula from simpler heavy-sedation approaches.

How to Prepare

Traditional preparation instructions for Zhen Gan Xi Feng Tang

Decoct in water. The mineral and shell ingredients (Dai Zhe Shi, Long Gu, Mu Li, and Gui Ban) should be crushed (捣碎) before decocting and ideally decocted first for 20 to 30 minutes before adding the remaining herbs. Dai Zhe Shi should be ground finely (轧细). Chuan Lian Zi should also be lightly crushed. Decoct the full formula in approximately 800 mL of water, reducing to about 300 mL. Strain and take warm in two divided doses per day.

Common Modifications

How practitioners adapt Zhen Gan Xi Feng Tang for specific situations

Added
Shi Gao

Sheng Shi Gao 30g, clears interior Heat and drains Fire

Zhang Xichun specified adding raw Gypsum when the patient has intense chest Heat, which he attributed to latent pathogenic factors transforming into Heat. Shi Gao powerfully clears this excess Heat from the Yang Ming level.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Zhen Gan Xi Feng Tang should not be used or requires extra caution

Avoid

Pregnancy. Niu Xi (Achyranthes) has blood-moving and downward-directing properties that may stimulate uterine contractions and risk miscarriage. Dai Zhe Shi and other heavy minerals are also not appropriate during pregnancy.

Avoid

Qi deficiency and Blood stasis patterns (气虚血瘀). This formula is designed for excess above with Yin deficiency below. Using it for stroke or hemiplegia caused by Qi deficiency (where Bu Yang Huan Wu Tang would be appropriate) could worsen the condition.

Caution

Spleen Yang deficiency or weak digestion. The formula contains many enriching, cloying, heavy, and sedating substances (minerals, shells, Yin-nourishing herbs) that can injure the Spleen and Stomach, causing poor appetite, loose stools, or abdominal distension.

Avoid

True Cold with false Heat patterns. If the patient's rising symptoms are due to Yang floating upward from Kidney Yang deficiency (not Liver Yang excess), this cooling and descending formula would further damage the depleted Yang.

Caution

Loose stools or diarrhea. The original text advises removing Gui Ban (turtle shell) and Dai Zhe Shi (hematite) if the bowels are loose, and adding Chi Shi Zhi instead.

Avoid

Wind-stroke caused by external Wind invasion (true Wind-stroke). Zhang Xichun explicitly warns against confusing internal Wind (from Liver Yang rising) with external Wind, as the treatment strategies are completely opposite.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. Niu Xi (Achyranthes, used here in a heavy 30g dose) is a well-known Blood-moving herb that strongly directs Qi and Blood downward, and is classically listed among herbs contraindicated in pregnancy due to risk of inducing uterine contractions and miscarriage. Chuan Lian Zi (Melia fruit) is also considered potentially harmful in pregnancy. Additionally, Dai Zhe Shi (hematite) and the heavy mineral/shell components are not suitable for pregnant women. This formula should not be used at any stage of pregnancy.

Breastfeeding

There is limited specific data on the safety of Zhen Gan Xi Feng Tang during breastfeeding. Chuan Lian Zi (Melia fruit) contains mildly toxic meliacins that could theoretically transfer to breast milk and should be used with caution. Dai Zhe Shi (hematite) and other mineral ingredients raise concerns about trace heavy metal exposure through breast milk. Sheng Mai Ya (raw barley sprout) is traditionally used to promote the return of breast milk (hui ru), meaning it may reduce lactation. The formula's overall cold and descending nature could theoretically affect the nursing infant's digestion. Use only under close practitioner supervision while breastfeeding, and consider alternatives if possible.

Children

This formula is not commonly used in young children, as the pattern it treats (Liver-Kidney Yin deficiency with Liver Yang rising causing stroke-like symptoms) is predominantly seen in middle-aged and older adults. However, modified versions have been used for pediatric conditions such as Tourette syndrome (childhood tic disorders), with reported efficacy in small studies. In such cases, dosages must be significantly reduced according to age and body weight (typically one-third to one-half of adult doses for school-age children). The heavy mineral and shell ingredients (Long Gu, Mu Li, Gui Ban, Dai Zhe Shi) can be hard on children's digestive systems, so Spleen-protecting herbs may need to be added. Use in children should only be under direct supervision of an experienced practitioner. Not suitable for infants or toddlers.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Zhen Gan Xi Feng Tang

Antihypertensive medications: This formula has demonstrated blood pressure-lowering effects in clinical studies. When used alongside pharmaceutical antihypertensives (ACE inhibitors, ARBs, calcium channel blockers, beta-blockers, or diuretics), there is a risk of additive hypotensive effects. Blood pressure should be monitored closely and medication doses may need adjustment.

Gan Cao (Glycyrrhiza/Licorice): Licorice root can cause pseudoaldosteronism with sodium retention and potassium loss, potentially counteracting diuretics and antihypertensives. It may also interact with digoxin (by enhancing toxicity through hypokalemia), corticosteroids, and warfarin.

Anticoagulants and antiplatelet drugs: Niu Xi (Achyranthes) and Bai Shao (White Peony) have blood-moving and blood-regulating properties. When combined with warfarin, heparin, aspirin, or clopidogrel, there may be an increased risk of bleeding.

Sedatives and CNS depressants: Long Gu (Dragon Bone) and Mu Li (Oyster Shell) have calming and spirit-settling properties. Combined with benzodiazepines, barbiturates, or other sedatives, excessive sedation is theoretically possible.

Calcium supplements and calcium-containing medications: The high mineral content (Long Gu, Mu Li, Gui Ban, Dai Zhe Shi) means this formula contributes significant calcium and iron. This may affect absorption of tetracycline antibiotics, fluoroquinolones, and levothyroxine if taken simultaneously. Separate doses by at least two hours.

Usage Guidance

Practical advice for getting the most out of Zhen Gan Xi Feng Tang

Best time to take

Twice daily, morning and evening, 30-60 minutes after meals (to reduce gastric irritation from the heavy mineral ingredients). Take warm.

Typical duration

Acute crisis: 3-7 days with close monitoring. Ongoing management of hypertension or chronic Liver Yang rising: 2-8 weeks, reassessed regularly by a practitioner.

Dietary advice

Avoid foods that aggravate Liver Yang rising: alcohol, coffee, strong tea, spicy or heavily seasoned foods, fried and greasy foods, and excessive red meat. These generate internal Heat and can provoke the upward movement of Qi and Blood that this formula aims to calm. Favor cooling, Yin-nourishing foods: celery, chrysanthemum tea, mung beans, cucumber, pears, watermelon, spinach, black sesame, and seaweed. These support the formula's cooling and descending action. Avoid emotional agitation around mealtimes and eat regular, moderate meals. Overeating burdens the Stomach and Spleen, which are already stressed by the formula's heavy mineral ingredients.

Zhen Gan Xi Feng Tang originates from Yi Xue Zhong Zhong Can Xi Lu (医学衷中参西录, Records of Medicine with Reference to East and West) by Zhang Xichun Late Qīng dynasty to early Republican era, first published 1918 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Zhen Gan Xi Feng Tang and its clinical use

Original indication from the Yi Xue Zhong Zhong Can Xi Lu (医学衷中参西录), Volume 7:

「治内中风证(亦名类中风,即西人所谓脑充血证),其脉弦长有力(即西医所谓血压过高),或上盛下虚,头目时常眩晕,或脑中时常作疼发热,或目胀耳鸣,或心中烦热,或时常噫气;或肢体渐觉不利,或口眼渐形歪斜,或面色如醉;甚或眩晕,至于颠仆,昏不知人,移时始醒,或醒后不能复元,精神短少,或肢体痿废,或成偏枯。」

Translation: "Treats internal Wind-stroke (also called 'stroke-like syndrome,' equivalent to what Western physicians call 'cerebral congestion'). The pulse is wiry, long, and forceful (what Western medicine calls high blood pressure). There may be excess above and deficiency below, with frequent dizziness, or hot pain in the head, or eye distension and ear ringing, or irritability and heat in the chest, or frequent belching. The limbs may gradually become unresponsive, the mouth and eye may gradually become deviated, or the face may appear flushed as if intoxicated. In severe cases, dizziness may lead to collapse and loss of consciousness, recovering only after some time, or unable to recover fully, with low spirits, limb weakness, or hemiplegia."


Formula rationale from the same text:

「是以方中重用牛膝以引血下行,此为治标之主药。而复深究病之本源,用龙骨、牡蛎、龟版、芍药以镇熄肝风,赭石以降胃降冲,玄参、天冬以清肺气,肺中清肃之气下行,自能镇制肝木。」

Translation: "Therefore the formula uses a large dose of Niu Xi to direct blood downward; this is the chief herb for treating the branch [acute symptoms]. To address the root cause in depth, Long Gu, Mu Li, Gui Ban, and Shao Yao are used to sedate and extinguish Liver Wind. Zhe Shi descends the Stomach and calms the Penetrating Vessel. Xuan Shen and Tian Dong clear Lung Qi, so that the Lung's pure descending force naturally restrains Liver Wood."


On the later addition of three herbs:

「盖肝为将军之官,其性刚果,若但用药强制,或转激发其反动之力。茵陈为青蒿之嫩者,得初春少阳生发之气,与肝木同气相求,泻肝热兼舒肝郁,实能将顺肝木之性。麦芽为谷之萌芽,生用之亦善将顺肝木之性,使不抑郁。川楝子善引肝气下达,又有折其反动之力。」

Translation: "The Liver is the general's organ, with a firm and resolute nature. If one only uses herbs to forcibly suppress it, this may instead provoke its rebellious force. Yin Chen is the young shoot of Qing Hao (sweet wormwood), imbued with the rising Qi of early spring's lesser Yang; it resonates with Liver Wood's nature, draining Liver Heat while relieving Liver constraint, thus gently guiding the Liver's nature. Raw Mai Ya (barley sprout) similarly guides the Liver's nature so it does not become depressed. Chuan Lian Zi directs Liver Qi downward and counters its rebellious force."

Historical Context

How Zhen Gan Xi Feng Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Zhen Gan Xi Feng Tang was created by Zhang Xichun (张锡纯, 1860-1933), one of the most influential physicians of the late Qing Dynasty and early Republican era. It was published in his major work, the Yi Xue Zhong Zhong Can Xi Lu (医学衷中参西录, "Records of Heart-Felt Experiences in Medicine with Reference to the West"), first published between 1918 and 1934. Zhang was a pioneer of the "integrative" movement who sought to reconcile traditional Chinese medical theory with Western anatomical and physiological knowledge.

Zhang himself noted that the formula originally contained only the heavy sedating and Yin-nourishing herbs. However, some patients found that the first dose actually made symptoms worse, with Qi and Blood seemingly surging upward more forcefully. He realized this was because the Liver, being "the general's organ" with a firm and unyielding nature, would rebel against pure forceful suppression. He then added Yin Chen (Artemisia capillaris), Sheng Mai Ya (raw barley sprout), and Chuan Lian Zi (Melia fruit) to gently guide and soothe the Liver's natural tendency toward free flow, preventing this rebound effect. This insight represents a remarkable example of clinical refinement based on observed outcomes.

Zhang explicitly discussed how this formula related to earlier developments in stroke theory. He credited the Song Dynasty physician Liu Hejian (刘河间) for first recognizing that stroke could arise from internal causes rather than external Wind. However, Zhang felt that Liu's actual prescriptions were not precise enough, and he saw his own formula as a more targeted approach. He also warned against the indiscriminate use of Wang Qingren's Bu Yang Huan Wu Tang (with its heavy dose of Huang Qi) for patients with strong, forceful pulses, citing a case where such misapplication led to sudden collapse.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Zhen Gan Xi Feng Tang

1

Systematic Review of RCTs: Zhen Gan Xi Feng Decoction for Essential Hypertension (2013)

Xiong XJ, Yang XC, Feng B, et al. Evidence-Based Complementary and Alternative Medicine. 2013; 2013: Article ID 982380.

This systematic review searched five major databases and included six randomized controlled trials evaluating the formula for essential hypertension. Meta-analysis suggested that the formula, alone or combined with antihypertensive drugs, may help lower blood pressure and improve clinical symptoms compared to conventional drugs alone. However, the authors cautioned that included trials had high methodological bias risk, small sample sizes, and heterogeneity, limiting the reliability of conclusions. They called for larger, more rigorous trials.

2

Systematic Review and Meta-Analysis Protocol: Herbal Medicine (Zhengan Xifeng Decoction) for Essential Hypertension (2019)

Huang Y, Chen Y, Cai H, et al. Medicine. 2019; 98(6): e14292.

A registered protocol for a comprehensive systematic review and meta-analysis aiming to evaluate the efficacy and safety of the formula for essential hypertension. The protocol planned to search nine major databases including EMBASE, Cochrane, PubMed, and multiple Chinese databases. This protocol highlights that despite widespread clinical use, high-quality evidence for the formula remains insufficient.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.