Shi Hu Ye Guang Wan

Dendrobium Pill for Night Vision · 石斛夜光丸

Also known as: Ye Guang Wan (夜光丸), Dendrobium Night Vision Pill

A classical formula for eye health, designed to nourish the Liver and Kidneys, clear deficiency Heat, and brighten the eyes. It is commonly used for blurred vision, early-stage cataracts, glaucoma, and other eye conditions caused by chronic depletion of the body's nourishing fluids, particularly in middle-aged and older adults.

Origin Rui Zhu Tang Jing Yan Fang (瑞竹堂经验方) by Sha Tumusu (沙图穆苏), later renamed and recorded in Yuan Ji Qi Wei (原机启微) by Ni Weide (倪维德) — Yuán dynasty, 1326 CE (original as Yè Guāng Wán); renamed 1370 CE
Composition 25 herbs
Tian Men Dong
King
Tian Men Dong
Ren Shen
King
Ren Shen
Tu Si Zi
King
Tu Si Zi
Wu Wei Zi
Deputy
Wu Wei Zi
Tian Men Dong
Deputy
Tian Men Dong
Gou Qi Zi
Deputy
Gou Qi Zi
Shu Di huang
Deputy
Shu Di huang
Shu Di huang
Deputy
Shu Di huang
+17
more
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Shi Hu Ye Guang Wan is designed to correct these specific patterns.

Why Shi Hu Ye Guang Wan addresses this pattern

This is the primary pattern addressed by the formula. When Liver and Kidney Yin become chronically depleted, the eyes lose their source of nourishment. In TCM, the Kidneys store essence (Jing) which rises to supply the eyes, while the Liver stores Blood that moistens them. When both organs are depleted, the eyes gradually lose clarity. The formula's large group of Yin-tonifying herbs (Tian Men Dong, Mai Men Dong, Sheng Di, Shu Di, Gou Qi Zi, Tu Si Zi, Shi Hu, Wu Wei Zi, Niu Xi) directly replenishes these depleted reserves, while Ren Shen, Fu Ling, and Shan Yao strengthen the Spleen to sustain ongoing production of Qi and Blood.

A practitioner would look for one or more of these signs

Blurry Vision

Gradual onset, progressive deterioration

Dry Eyes

Due to insufficient fluid nourishment

Dizziness

From Yin deficiency failing to anchor Yang

Tinnitus

Kidney essence failing to fill the ears

Lower Back Pain

Lumbar soreness and weak knees

Night Sweats

Deficiency Heat forcing fluids outward at night

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Shi Hu Ye Guang Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, cataracts (called 'round opacity internal obstruction' or yuan yi nei zhang, 圆翳内障) develop when the Liver and Kidneys can no longer supply sufficient essence and nourishing fluids to the eyes. The lens is considered part of the 'spirit water' (shen shui, 神水) system, which depends on the upward flow of Kidney essence through the Liver channel to maintain clarity. As people age, their Kidney essence naturally declines. When compounded by overwork, chronic illness, or constitutional weakness, the essence becomes too depleted to keep the lens clear, and it gradually becomes cloudy. If deficiency Fire is also present, the Heat accelerates this deterioration, changing the color of the spirit water from clear to green-tinged, then white, and eventually opaque.

Why Shi Hu Ye Guang Wan Helps

Shi Hu Ye Guang Wan directly addresses the root mechanism by replenishing Kidney essence and Liver Blood through its core Yin-nourishing ingredients: Shu Di Huang, Gou Qi Zi, Tu Si Zi, Tian Men Dong, and Shi Hu work together to refill the depleted reserves. The formula also clears the deficiency Fire (via Huang Lian, Ling Yang Jiao, Shui Niu Jiao) that accelerates lens degeneration. Additionally, eye-specific herbs like Ju Hua, Jue Ming Zi, and Qing Xiang Zi direct the formula's benefit specifically to the eyes. The formula is recommended for early-stage cataracts and works best with extended use, reflecting its gradual, nourishing approach.

Also commonly used for

Blurry Vision

Progressive visual decline in middle-aged and elderly

Rhinitis

Including macular degeneration

Optic Neuritis

Inflammation of the optic nerve

Eye Floaters

Vitreous floaters from Liver-Kidney deficiency

Viral Conjunctivitis

Chronic conjunctivitis with Yin deficiency background

High Blood Pressure

When due to Liver-Kidney Yin deficiency with ascending Yang

Headaches

Chronic or migraine headaches from Yin deficiency

What This Formula Does

Every TCM formula has a specific set of actions — here's what Shi Hu Ye Guang Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Shi Hu Ye Guang Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Shi Hu Ye Guang Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Shi Hu Ye Guang Wan works at the root level.

The disease pattern addressed by Shi Hu Ye Guang Wan centers on the relationship between the Liver, Kidneys, and the eyes. In TCM theory, the Liver "opens into the eyes" — meaning the health of the eyes depends fundamentally on adequate nourishment from the Liver. The Kidneys, in turn, store the body's essential Yin (the deep, cooling, moistening reserves), and Kidney Yin is the root source that replenishes Liver Yin and Liver Blood.

When the Kidneys and Liver both become depleted in Yin over time — through aging, chronic illness, overwork, or emotional strain — two problems develop simultaneously. First, the eyes lose their nourishing supply: Yin, Blood, and vital fluids can no longer ascend to moisten and sustain the eyes, leading to dryness, blurred vision, and gradual clouding (what classical texts call "inner obstruction," or cataracts in modern terms). Second, when Yin becomes too weak to anchor Yang, deficiency Heat flares upward. This "false Fire" rises to the head and eyes, further drying them out and disturbing the clear fluids ("spirit water") that maintain normal vision. The classical text describes this as a slow, progressive loss: first a haze like fog, then dark floaters, then double vision, and ultimately near-total loss of useful sight.

Because the Spleen and Stomach are responsible for generating the Qi and Blood that ultimately supply the Liver and Kidneys, any weakness in these digestive organs compounds the problem — the raw materials for Yin and Blood replenishment are insufficient. The formula therefore addresses not just the Liver-Kidney Yin deficiency and the rising deficiency Fire, but also supports the Spleen's ability to produce new resources, while simultaneously clearing Wind-Heat from the eye region to relieve surface symptoms.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly sweet and slightly bitter — sweet to tonify Yin and Blood, bitter to clear deficiency Heat and drain Fire from the Liver, with mild pungent notes from wind-dispersing herbs.

Channels Entered

Ingredients

25 herbs

The herbs that make up Shi Hu Ye Guang Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Tian Men Dong

Tian Men Dong

Chinese asparagus tubers

Dosage 30g
Temperature Cold
Taste Bitter, Sweet
Organ Affinity Kidneys, Lungs

Role in Shi Hu Ye Guang Wan

Strongly nourishes Kidney Yin and clears deficiency Heat from the Lung and Kidney. As one of the primary King herbs, it replenishes the deep Yin reserves that sustain the eyes, working at the root level to restore the vital fluids that have become depleted.
Ren Shen

Ren Shen

Ginseng

Dosage 30g
Temperature Warm
Taste Bitter, Sweet
Organ Affinity Heart, Lungs, Spleen

Role in Shi Hu Ye Guang Wan

Powerfully tonifies the original Qi and strengthens the Spleen, which is the source of Qi and Blood production. Without adequate Qi, the nourishing Yin substances cannot be transported upward to reach the eyes. Ren Shen ensures the body can generate and deliver essential nutrients.
Tu Si Zi

Tu Si Zi

Cuscuta seeds

Dosage 23g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver, Spleen

Role in Shi Hu Ye Guang Wan

Tonifies both Kidney Yin and Yang in a gentle, balanced manner, and specifically benefits the eyes. It is a key Kidney-nourishing herb that fills essence (Jing) and supports visual acuity, anchoring the formula's Kidney-restoring strategy.
Deputies — Assists and enhances the King
Wu Wei Zi

Wu Wei Zi

Schisandra berries

Dosage 15g
Temperature Warm
Taste Sour, Sweet
Organ Affinity Heart, Kidneys, Lungs

Role in Shi Hu Ye Guang Wan

Astringes and consolidates Kidney essence, preventing the further leakage of Yin fluids. Its sour taste gathers and holds the vital substances that nourish the eyes, complementing the King herbs' tonifying action.
Tian Men Dong

Tian Men Dong

Chinese asparagus tubers

Dosage 30g
Temperature Cold
Taste Bitter, Sweet
Organ Affinity Kidneys, Lungs

Role in Shi Hu Ye Guang Wan

Nourishes Yin and generates fluids, particularly for the Lung and Stomach. Pairs with Tian Men Dong to create a powerful Yin-restoring duo that moistens dryness and cools deficiency Heat from below.
Gou Qi Zi

Gou Qi Zi

Goji berries

Dosage 23g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Shi Hu Ye Guang Wan

Nourishes Liver and Kidney Yin, enriches the Blood, and specifically brightens the eyes. One of the most important herbs for eye nourishment, it directly supplements the Liver Blood and Kidney essence that sustain vision.
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 30g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Shi Hu Ye Guang Wan

Cools the Blood and nourishes Yin, clearing deficiency Heat. Its cool nature counteracts the empty Fire that rises upward to disturb the eyes when Yin is depleted.
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 30g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Shi Hu Ye Guang Wan

Strongly tonifies Kidney Yin and nourishes the Blood and essence. Where Sheng Di cools and clears, Shu Di warms slightly and fills, providing the deep nutritive substance the Kidneys need to send essence upward to the eyes.
Niu Xi

Niu Xi

Achyranthes roots

Dosage 23g
Temperature Neutral
Taste Bitter, Sour
Organ Affinity Kidneys, Liver
Preparation Prepared with wine (酒浸)

Role in Shi Hu Ye Guang Wan

Tonifies the Liver and Kidneys, strengthens the sinews and bones, and conducts Blood downward. In this formula, it reinforces the Kidney-nourishing strategy and helps anchor the rising deficiency Fire by guiding it back downward.
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 30g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Shi Hu Ye Guang Wan

Strengthens the Spleen and drains dampness, supporting Ren Shen in fortifying the middle burner. The Spleen is responsible for transporting nutrients, so this herb ensures the tonifying herbs are properly absorbed and distributed.
Xing Ren

Xing Ren

Apricot seeds

Dosage 15g
Temperature Warm
Taste Bitter, Sweet
Organ Affinity Large Intestine, Lungs

Role in Shi Hu Ye Guang Wan

Descends Lung Qi and opens the waterways. The Lungs govern the downward movement of fluids; by regulating Lung Qi, this herb ensures proper distribution of moisture and prevents fluid stagnation that could cloud the eyes.
Assistants — Supports or moderates other herbs
Shi Hu

Shi Hu

Dendrobium

Dosage 15g
Temperature Cool
Taste Sweet
Organ Affinity Stomach, Kidneys, Lungs
Preparation Soaked in wine, then dried and ground (酒浸,焙干,另捣)

Role in Shi Hu Ye Guang Wan

Nourishes Stomach and Kidney Yin, generates fluids, and clears deficiency Heat. Although the formula is named after this herb, in the classical role assignment from the Yuan Ji Qi Wei it serves as an Assistant that supports the Yin-nourishing strategy and specifically benefits visual clarity.
Rou Cong Rong

Rou Cong Rong

Desert-living cistanches

Dosage 15g
Temperature Warm
Taste Salty, Sweet
Organ Affinity Kidneys, Large Intestine

Role in Shi Hu Ye Guang Wan

Gently warms and tonifies Kidney Yang and essence without drying. It balances the many cool Yin-tonifying herbs, preventing the formula from becoming too cold, and supports the Kidney's function of generating essence for the eyes.
Ju Hua

Ju Hua

Chrysanthemum flowers

Dosage 23g
Temperature Cool
Taste Bitter, Sweet
Organ Affinity Liver, Lungs

Role in Shi Hu Ye Guang Wan

Clears the Liver, brightens the eyes, and disperses wind-Heat from the head and eyes. It directly addresses eye redness, dryness, and blurred vision while calming ascendant Liver Yang.
Bai Jie Zi

Bai Jie Zi

White mustard seeds

Dosage 15g
Temperature Warm
Taste Bitter
Organ Affinity Stomach, Lungs
Preparation Salt-fried (盐炒)

Role in Shi Hu Ye Guang Wan

Calms the Liver, subdues ascendant Yang, and dispels Wind from the eyes. It addresses eye itching, tearing, and blurred vision caused by Liver Wind rising upward, and helps remove superficial visual obstructions.
Qing Xiang Zi

Qing Xiang Zi

Celosia seed

Dosage 15g
Temperature Cool
Taste Bitter
Organ Affinity Liver, Large Intestine

Role in Shi Hu Ye Guang Wan

Clears Liver Heat and improves visual acuity. It directly treats eye conditions including cataracts and glaucoma by draining excess Heat from the Liver channel that rises to disturb the eyes.
Chuan Xiong

Chuan Xiong

Szechuan lovage roots

Dosage 15g
Temperature Warm
Taste Pungent
Organ Affinity Gallbladder, Liver, Pericardium

Role in Shi Hu Ye Guang Wan

Invigorates Blood circulation and moves Qi, particularly in the head region. It ensures that the nourishing substances from the tonifying herbs actually reach the eyes by promoting Blood flow to the head and preventing stasis.
Zhi Ke

Zhi Ke

Bitter oranges

Dosage 15g
Temperature Warm
Taste Bitter, Pungent, Sour
Organ Affinity Spleen, Stomach
Preparation Bran-fried (麸炒)

Role in Shi Hu Ye Guang Wan

Regulates Qi movement and prevents stagnation. With so many rich, cloying tonifying herbs in the formula, Zhi Ke keeps the Qi flowing smoothly to prevent bloating and ensure proper absorption.
Shan Yao

Shan Yao

Yam

Dosage 23g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Lungs, Spleen

Role in Shi Hu Ye Guang Wan

Tonifies the Spleen, Lung, and Kidney simultaneously. It supports the middle burner's digestive capacity while gently nourishing the Kidneys, serving as a bridge between the Qi-tonifying and Yin-tonifying aspects of the formula.
Gan Cao

Gan Cao

Liquorice

Dosage 15g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach
Preparation Honey-prepared (炙甘草)

Role in Shi Hu Ye Guang Wan

Tonifies the Spleen and harmonizes the actions of all 25 herbs, moderating any conflicting properties and ensuring smooth cooperation among the formula's many ingredients.
Envoys — Directs the formula to its target
Fang Feng

Fang Feng

Saposhnikovia roots

Dosage 15g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Urinary Bladder, Liver, Spleen

Role in Shi Hu Ye Guang Wan

Disperses external Wind from the head and eyes while guiding the formula's actions to the upper body. It addresses Wind-related eye symptoms like excessive tearing and itching, and directs the other herbs toward the eye region.
Huang Lian

Huang Lian

Goldthread rhizomes

Dosage 15g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Large Intestine, Liver, Spleen, Stomach

Role in Shi Hu Ye Guang Wan

Strongly clears Heart and Liver Fire, draining the excess Heat that has risen to disturb the eyes. Its bitter-cold nature directly counteracts the burning, inflammatory quality of deficiency Fire affecting the eyes.
Jue Ming Zi

Jue Ming Zi

Cassia seeds

Dosage 23g
Temperature Cool
Taste Bitter, Sweet
Organ Affinity Large Intestine, Liver
Preparation Dry-fried (炒)

Role in Shi Hu Ye Guang Wan

Clears Liver Heat and brightens the eyes, specifically targeting visual cloudiness and elevated intraocular pressure. Its name literally means 'seed that decides brightness,' reflecting its strong eye-clarifying action.
Ling Yang Jiao

Ling Yang Jiao

Saiga antelope's horns

Dosage 15g
Temperature Cold
Taste Salty
Organ Affinity Heart, Liver
Preparation Ground to powder separately and taken with the decoction (另研冲服)

Role in Shi Hu Ye Guang Wan

Powerfully clears Liver Heat, calms Liver Wind, and brightens the eyes. It addresses the most severe manifestations of ascending Liver Fire and internal Wind, such as headache, dizziness, and acute visual disturbance.
Shui Niu Jiao

Shui Niu Jiao

Water buffalo horns

Dosage 15g (concentrated powder)
Temperature Cold
Taste Bitter, Salty
Organ Affinity Stomach, Heart, Liver
Preparation Used as concentrated powder (浓缩粉)

Role in Shi Hu Ye Guang Wan

Clears Heat from the Blood level and cools the Liver, used as a modern substitute for the now-prohibited Xi Jiao (rhinoceros horn). It drains deep-level Heat from the Blood and calms internal stirring that disturbs the eyes.

Why This Combination Works

How the herbs in Shi Hu Ye Guang Wan complement each other

Overall strategy

This formula addresses a complex condition where chronic Liver and Kidney Yin depletion allows deficiency Fire to flare upward and internal Wind to stir, depriving the eyes of nourishment while simultaneously assaulting them with pathological Heat. The prescription therefore combines deep Yin tonification at its core with Heat-clearing, Wind-calming, and Qi-supporting herbs to restore the eyes from both root and branch.

King herbs

Tian Men Dong, Ren Shen, and Tu Si Zi form the King tier. Tian Men Dong strongly replenishes Kidney Yin, the deep reservoir that ultimately supplies the eyes with nourishing fluids. Tu Si Zi gently fills Kidney essence and has a specific affinity for benefiting vision. Ren Shen powerfully strengthens the Spleen and original Qi, which is essential because without strong Qi to transport and transform, Yin-nourishing substances cannot be generated or delivered to the eyes. Together they address the two fundamental deficiencies: depleted Yin and weakened Qi.

Deputy herbs

A large team of Deputies reinforces the Kings from multiple angles. Mai Men Dong pairs with Tian Men Dong to create the classical "Two Winters" (Er Dong) combination for powerful Yin restoration. Sheng Di Huang cools the Blood and clears deficiency Heat, while Shu Di Huang deeply nourishes Kidney essence and Blood. Gou Qi Zi and Niu Xi specifically strengthen the Liver-Kidney axis and benefit the eyes. Wu Wei Zi astringes leaking essence to prevent further loss. Fu Ling and Ku Xing Ren support the middle and upper burners respectively, ensuring fluid metabolism functions properly so the tonifying herbs can be properly utilized.

Assistant herbs

The Assistants divide into three functional groups. First, the reinforcing Assistants: Shi Hu, Rou Cong Rong, and Shan Yao further strengthen the Yin-nourishing and Qi-supporting core. Rou Cong Rong is notable as a restraining Assistant as well: its mild warmth prevents the many cold, Yin-nourishing herbs from damaging the Spleen's digestive Yang. Second, the eye-directing Assistants: Ju Hua, Bai Ji Li, and Qing Xiang Zi clear Liver Heat and dispel Wind from the eyes, directly treating the symptoms of blurred vision, tearing, and visual cloudiness. Third, Chuan Xiong and Zhi Ke move Blood and Qi respectively, counteracting the tendency of rich, heavy tonifying formulas to create stagnation. Gan Cao harmonizes all ingredients.

Envoy herbs

Fang Feng, Huang Lian, Jue Ming Zi, Ling Yang Jiao, and Shui Niu Jiao serve as Envoys that scatter stagnation, drain Heat, and direct the formula's action to the eyes and head. Ling Yang Jiao and Shui Niu Jiao are the most powerful Heat-clearing and Wind-calming agents in the formula, addressing the acute manifestations of rising Fire. Huang Lian directly drains Heart and Liver Fire. Fang Feng guides the formula upward and outward to dispel Wind from the eye region. Jue Ming Zi clears Liver Heat with a specific affinity for brightening the eyes.

Notable synergies

The Tian Men Dong and Mai Men Dong pairing ("Two Winters") creates a synergistic Yin-nourishing effect greater than either alone. Sheng Di Huang and Shu Di Huang ("Two Rehmannias") work together to both cool-and-clear and nourish-and-fill simultaneously. Gou Qi Zi and Ju Hua form a classic Liver-eye pair: one nourishes from below while the other clears from above. The combination of Ren Shen, Fu Ling, Shan Yao, and Gan Cao embedded within the formula echoes the Si Jun Zi Tang structure, ensuring the Spleen can support this large, rich prescription.

How to Prepare

Traditional preparation instructions for Shi Hu Ye Guang Wan

Grind all 25 herbs into a fine powder and mix with refined honey to form pills. The traditional pill size is approximately 9 grams for large honey pills. The standard dose is one large honey pill (9g) or 6g of water-honey pills, taken orally twice daily. For water-honey pill preparations, the dose is 6g per serving, twice daily.

When adapted as a decoction for individualized treatment, reduce the number of herbs according to the primary pattern. Practitioners typically adjust based on the relative severity of Yin deficiency versus internal Heat. The formula is meant for gradual, long-term use rather than acute treatment.

Common Modifications

How practitioners adapt Shi Hu Ye Guang Wan for specific situations

Added
Chen Pi

6-9g, regulates Qi and dries Dampness

Sha Ren

3-6g, transforms Dampness and harmonizes the Stomach

The base formula is rich and cloying. When signs of Phlegm-Dampness appear, adding Chen Pi and Sha Ren prevents digestive stagnation and helps the Stomach absorb the heavy tonifying ingredients.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Shi Hu Ye Guang Wan should not be used or requires extra caution

Caution

Spleen deficiency with loose stools or diarrhea. The formula contains many rich, Yin-nourishing herbs (Shu Di Huang, Tian Dong, Mai Dong, Rou Cong Rong) that are cloying and difficult to digest, which may worsen Spleen deficiency and cause digestive upset.

Caution

External pathogenic invasion (Wind-Cold or Wind-Heat) with acute symptoms such as fever, chills, or sore throat. Tonifying formulas should not be used during active external conditions, as they may trap the pathogen inside.

Caution

Eye conditions caused by excess Liver Fire or Damp-Heat without underlying Yin deficiency. This formula is designed for deficiency patterns and would not be appropriate for purely excess conditions.

Caution

Diabetes or significant blood sugar dysregulation. The honey-bound pill form contains sugar, and the formula's tonifying herbs may affect glucose metabolism. Medical supervision is recommended.

Avoid

Pregnancy. The formula contains Niu Xi (Achyranthes root) which promotes downward movement of blood and may stimulate uterine activity. Chuan Xiong also moves blood. Use only under strict medical supervision.

Avoid

Known allergy or hypersensitivity to any of the 25 ingredients in the formula.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The formula contains Niu Xi (Achyranthes root), which has a strong downward-directing action and is classically noted for promoting blood movement in the lower body, posing a risk of stimulating uterine contractions. Chuan Xiong (Sichuan Lovage) is also a blood-moving herb that should be used cautiously in pregnancy. Additionally, Ku Xing Ren (Bitter Apricot Seed) contains trace amygdalin. Ling Yang Jiao (Antelope Horn) and Shui Niu Jiao (Water Buffalo Horn) are potent cooling substances whose safety in pregnancy has not been established. Pregnant women should avoid this formula unless specifically prescribed and monitored by a qualified practitioner.

Breastfeeding

Use with caution during breastfeeding and only under practitioner guidance. While most of the herbs in this formula are nourishing tonics unlikely to cause direct harm, several considerations apply. Huang Lian (Coptis) is very bitter and cold, and its alkaloid berberine can transfer into breast milk, potentially causing digestive upset in the infant. Ku Xing Ren (Bitter Apricot Seed) contains trace amygdalin, a precursor to hydrogen cyanide, and its transfer to breast milk has not been adequately studied. The animal-derived ingredients (Ling Yang Jiao, Shui Niu Jiao) have not been evaluated for breastfeeding safety. Nursing mothers should consult a qualified practitioner before use.

Children

This formula is generally not recommended for children under 12 years of age. The pattern it treats — chronic Liver-Kidney Yin deficiency with deficiency Fire — is predominantly an adult and elderly condition resulting from long-term depletion, and is uncommon in children. The large number of ingredients (25 herbs) and the richness of the Yin-tonifying herbs make it a heavy formula that could overwhelm a child's digestive system. If a practitioner determines it is necessary for an adolescent (over 12), the dose should be reduced to approximately one-third to one-half of the adult dose, adjusted by body weight and constitution. The Spleen-supporting herbs (Ren Shen, Shan Yao, Fu Ling) in the formula help offset digestive burden, but monitoring for loose stools or appetite loss is advisable.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Shi Hu Ye Guang Wan

Anticoagulants and antiplatelet drugs: Chuan Xiong (Sichuan Lovage) and Niu Xi (Achyranthes) both promote blood circulation. When combined with warfarin, heparin, aspirin, or clopidogrel, there is a theoretical risk of enhanced anticoagulant effects and increased bleeding tendency.

Antihypertensive medications: Several herbs in this formula have blood-pressure-lowering properties, including Ju Hua (Chrysanthemum), Jue Ming Zi (Cassia Seed), and Ling Yang Jiao (Antelope Horn). Combined use with antihypertensive drugs may cause additive hypotensive effects.

Hypoglycemic drugs: Ren Shen (Ginseng) and Shan Yao (Chinese Yam) may affect blood glucose levels. Patients taking insulin or oral hypoglycemic agents should monitor blood sugar closely, and the honey excipient in pill form adds a small sugar load.

Cardiac glycosides (digoxin): Gan Cao (Licorice) can cause potassium depletion with prolonged use, which may potentiate digoxin toxicity. Patients on digoxin should be monitored for hypokalemia.

Corticosteroids and diuretics: Gan Cao's mineralocorticoid-like effects may compound fluid retention and potassium loss when taken with corticosteroids or potassium-wasting diuretics.

Usage Guidance

Practical advice for getting the most out of Shi Hu Ye Guang Wan

Best time to take

Twice daily, ideally 30 minutes after meals with warm water or warm lightly salted water (as noted in the classical instructions). The classical text also suggests taking it in the late morning after an earlier dose of Ci Zhu Wan.

Typical duration

Long-term use over 4–12 weeks or longer, reassessed periodically by a practitioner. As the classical text states, this formula 'benefits through gentleness and duration, not through speed.'

Dietary advice

Avoid spicy, fried, greasy, and heavily seasoned foods, which can generate Heat and counteract the formula's cooling, Yin-nourishing effects. Alcohol and tobacco should be strictly avoided as they damage Yin and aggravate Liver Fire. Caffeine and strong tea should be limited as they can dry fluids and disturb the spirit. Foods that support the formula's action include dark leafy greens, goji berries (Gou Qi Zi), chrysanthemum tea, black sesame seeds, mulberries, and foods rich in beta-carotene such as carrots and sweet potatoes. Adequate hydration with warm or room-temperature water is important. Cold, raw foods and iced beverages should be moderated to protect the Spleen, which needs to function well to convert nutrients into the Yin and Blood being replenished.

Shi Hu Ye Guang Wan originates from Rui Zhu Tang Jing Yan Fang (瑞竹堂经验方) by Sha Tumusu (沙图穆苏), later renamed and recorded in Yuan Ji Qi Wei (原机启微) by Ni Weide (倪维德) Yuán dynasty, 1326 CE (original as Yè Guāng Wán); renamed 1370 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Shi Hu Ye Guang Wan and its clinical use

From the Yuan Ji Qi Wei (原机启微) by Ni Weide:

「上方,羡补药也,补上治下,利以缓,利以久,不利以速也。故君以天门冬、人参、菟丝子之通肾安神,强阴填精也;臣以五味子、麦门冬、杏仁、茯苓、枸杞子、牛膝、生熟地黄之敛气除湿、凉血补血也;佐以甘菊花、刺蒺藜、石斛、苁蓉、川芎、甘草、枳壳、山药、青葙子之疗风治虚,益气祛毒也;使以防风、黄连、决明子、羚羊角、犀角之散滞泄热,解结明目也。阴虚不能配阳之病,亦宜服之。此从则顺之治法也。」

Translation: "This formula is a rich supplementing medicine. It supplements the upper and treats the lower; it benefits through gentleness, benefits through duration, and does not benefit through speed. The Chief herbs — Tian Men Dong, Ren Shen, and Tu Si Zi — open the Kidneys, calm the spirit, strengthen Yin, and fill the essence. The Deputies — Wu Wei Zi, Mai Men Dong, Xing Ren, Fu Ling, Gou Qi Zi, Niu Xi, and raw and prepared Rehmannia — restrain Qi, eliminate Dampness, cool the Blood, and supplement the Blood. The Assistants — Ju Hua, Ji Li, Shi Hu, Rou Cong Rong, Chuan Xiong, Gan Cao, Zhi Qiao, Shan Yao, and Qing Xiang Zi — treat Wind, address deficiency, boost Qi, and dispel toxins. The Envoys — Fang Feng, Huang Lian, Jue Ming Zi, Ling Yang Jiao, and Xi Jiao — scatter stagnation, drain Heat, resolve binding, and brighten the eyes. It is also suitable for conditions where Yin is too weak to balance Yang. This is a treatment method that follows the natural order."


From the Yuan Ji Qi Wei on the disease mechanism addressed by this formula:

「其病无眵泪痛痒羞明紧涩之证。初但昏如雾露中行,渐空中有黑花,又渐睹物成二体,久则光不收,遂为废疾。」

Translation: "This disease presents with no eye discharge, tearing, pain, itching, photophobia, or grittiness. At first, vision is merely hazy as if walking through fog; gradually, dark floaters appear in the visual field; then objects are seen as double; and eventually the eyes can no longer focus light, becoming a disabling condition."

Historical Context

How Shi Hu Ye Guang Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

The formula that would become Shi Hu Ye Guang Wan first appeared under the name "Ye Guang Wan" (Night Vision Pill) in the Rui Zhu Tang Jing Yan Fang (瑞竹堂经验方), compiled in 1326 by the Yuan Dynasty Mongolian physician Sha Tumusu (沙图穆苏). This makes it one of the earliest comprehensive Yin-nourishing eye formulas in Chinese medical history.

The renowned Yuan-to-early-Ming ophthalmologist Ni Weide (倪维德, 1303–1377), styled "Chìshan Laoren" (敕山老人), subsequently incorporated and renamed the formula as "Shi Hu Ye Guang Wan" in his landmark ophthalmology text Yuan Ji Qi Wei (原机启微, published 1370). Ni Weide provided a detailed analysis of the formula's composition using the classical Jun-Chen-Zuo-Shi (Chief-Deputy-Assistant-Envoy) framework, explaining how the 25 ingredients work together. His text became one of the most influential ophthalmology works in Chinese medicine, and this formula became its most celebrated prescription.

Over the centuries, later physicians modified the base formula for different clinical needs. The Ming-dynasty physician Zhou Yangqing removed Xing Ren and added Gu Jing Cao, Mi Meng Hua, and Dang Gui to enhance its ability to clear visual obstructions. The Qing-dynasty physician Wu Shichang simplified it to just seven core herbs in his Qi Fang Lei Bian. Related derivatives include Gu Ben Huan Jing Wan (from the Jing Yue Quan Shu) and Hu Po Huan Jing Wan. In the modern era, the formula has been included in the Chinese Pharmacopoeia as an approved patent medicine (中成药), and it remains one of the most widely used traditional eye care preparations in China.

Modern Research

A published study investigating the pharmacological effects or clinical outcomes of Shi Hu Ye Guang Wan

1

Shihu Yeguang Pill protects against bright light-induced photoreceptor degeneration in part through suppressing photoreceptor apoptosis (Preclinical animal study, 2020)

Wu H, Xu J, Du X, Cui J, Zhang T, Chen Y. Biomedicine & Pharmacotherapy. 2020; 126: 110050.

This mouse study found that Shihu Yeguang Pill treatment protected retinas from bright light-induced photoreceptor damage. The formula partially normalized the abnormal expression of pro-apoptotic genes (c-fos, c-jun) and anti-apoptotic genes (bcl-2) as well as the inflammatory marker TNF-α in light-exposed retinas. This was the first study to provide experimental evidence for SYP's protective effect on photoreceptor cells, supporting its traditional use for retinal degenerative diseases.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.