Ming Mu Di Huang Wan

Rehmannia Pill for Brightening the Eyes · 明目地黄丸

Also known as: Improve Vision Pill with Rehmannia, Rehmannia Pills to Brighten the Eyes

A classical formula designed to nourish the Liver and Kidneys in order to support eye health. It is used for symptoms such as dry or gritty eyes, sensitivity to light, blurred vision, and watery eyes caused by Wind, all stemming from an underlying deficiency of Liver and Kidney Yin. It builds on the well-known Liu Wei Di Huang Wan (Six-Ingredient Pill with Rehmannia) by adding herbs that specifically benefit the eyes, nourish the Blood, and calm overactive Liver Yang.

Origin Shěn Shì Yáo Hán (审视瑶函, Discerning Patterns and Guiding Remedies for the Eyes) by Fù Rényǔ (傅仁宇) — Míng dynasty, 1644 CE
Composition 12 herbs
Shu Di Huang
King
Shu Di Huang
Shan Zhu Yu
Deputy
Shan Zhu Yu
Shan Yao
Deputy
Shan Yao
Gou Qi Zi
Deputy
Gou Qi Zi
Ju Hua
Assistant
Ju Hua
Dang Gui
Assistant
Dang Gui
Bai Shao
Assistant
Bai Shao
Ji Li
Assistant
Ji Li
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Ming Mu Di Huang Wan is designed to correct these specific patterns.

Why Ming Mu Di Huang Wan addresses this pattern

When the Yin of both the Liver and Kidneys becomes depleted, the eyes lose their source of nourishment. In TCM, the Kidneys store Essence that generates marrow and nourishes the brain, while the Liver stores Blood and opens to the eyes. When Kidney Yin is insufficient, it fails to nourish Liver Yin, leading to a combined deficiency. The eyes, being the sensory opening of the Liver, are among the first organs to show signs of this depletion: dryness, grittiness, blurred vision, and light sensitivity.

Ming Mu Di Huang Wan addresses this through its Liu Wei Di Huang Wan base, which deeply replenishes Kidney Yin with Shu Di Huang, Shan Zhu Yu, and Shan Yao. The added herbs (Gou Qi Zi, Dang Gui, Bai Shao) specifically direct nourishment to the Liver and its Blood, while Ju Hua, Ji Li, and Shi Jue Ming clear and calm the Liver to benefit the eyes directly. The formula thus treats both the root (Kidney and Liver Yin deficiency) and the branch (eye symptoms).

A practitioner would look for one or more of these signs

Blurry Vision

Gradual onset, worse with prolonged use of the eyes

Dry Eyes

Gritty or sandy sensation, reduced tear production

Photophobia

Sensitivity to light, discomfort in bright environments

Excessive Sweating

Watering of the eyes when exposed to wind (迎风流泪)

Dizziness

Light-headedness from Yin deficiency failing to anchor Yang

Tinnitus

Ringing in the ears from Kidney Yin deficiency

Lower Back Pain

Soreness and weakness of the lower back and knees

Night Sweats

Reflecting deficiency Heat from depleted Yin

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Ming Mu Di Huang Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM views chronic dry eyes as primarily a problem of insufficient nourishment reaching the eyes. The Liver 'opens to the eyes' and its Blood moistens them, while the Kidneys store the Essence that is the deep reservoir supporting Liver Blood. When Liver and Kidney Yin become depleted over time (through aging, overwork, prolonged screen use, chronic illness, or excessive emotional stress), the eyes dry out because they are no longer being adequately nourished from below. In addition, Yin deficiency can generate deficiency Heat, which further evaporates the fluids that should moisten the eyes.

Why Ming Mu Di Huang Wan Helps

Ming Mu Di Huang Wan addresses dry eyes by restoring the deep source of nourishment. Shu Di Huang and Shan Zhu Yu replenish Kidney Yin and Essence, rebuilding the reservoir. Gou Qi Zi nourishes Liver and Kidney Yin while directly benefiting the eyes. Dang Gui and Bai Shao supplement Liver Blood, providing the moisture the eyes need. Mu Dan Pi clears the deficiency Heat that can evaporate eye moisture, and Ju Hua clears Heat and brightens the eyes. This formula is most appropriate for dry eyes that develop gradually and are accompanied by other signs of Yin deficiency like a dry mouth, lower back soreness, or fatigue.

Also commonly used for

Cataract

Early-stage age-related cataracts with Liver-Kidney Yin deficiency pattern

Glaucoma

Chronic open-angle type with Yin deficiency and Liver Yang rising

Central Serous Chorioretinopathy

Central retinal inflammation with Yin deficiency pattern

Optic Neuritis

When presenting with Liver-Kidney Yin deficiency signs

Photophobia

Chronic light sensitivity from deficiency, not acute infection

Excessive Sweating

Tearing triggered by wind exposure due to Yin deficiency

Macular Degeneration

Age-related macular changes with Liver-Kidney deficiency

Diabetic Neuropathy

Early stages with Yin deficiency pattern

Night Blindness

Reduced night vision from Liver Blood and Kidney Essence deficiency

What This Formula Does

Every TCM formula has a specific set of actions — here's what Ming Mu Di Huang Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Ming Mu Di Huang Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Ming Mu Di Huang Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Ming Mu Di Huang Wan works at the root level.

In TCM, the eyes depend on nourishment from the Liver and Kidneys more than any other organ pair. The Liver stores Blood and "opens to the eyes" (肝开窍于目), meaning the Liver supplies Blood and Yin fluids that keep the eyes moist, comfortable, and able to see clearly. The Kidneys store Essence (Jing), which is the deepest source of Yin in the body and provides the foundation for all the body's fluids and nourishing substances. When Kidney Essence is abundant, it generates sufficient Yin to support the Liver and ultimately the eyes.

When the Kidneys weaken over time (from aging, overwork, chronic illness, or constitutional factors), Kidney Yin becomes depleted. Because the Liver and Kidneys share a common Yin foundation (a relationship described as "Liver and Kidney share the same source," 肝肾同源), Kidney Yin depletion inevitably leads to Liver Yin and Liver Blood insufficiency. Without enough Liver Blood to nourish them, the eyes become dry, gritty, and light-sensitive. Vision grows blurry. Furthermore, when Yin is insufficient, it can no longer properly restrain Yang. Deficiency Heat or mildly rising Liver Yang develops, causing the eyes to tear when exposed to wind. In essence, the root of the problem is below (in the Kidneys), but the symptoms manifest above (in the eyes).

Ming Mu Di Huang Wan addresses this by replenishing the depleted Kidney Yin and Liver Blood at their source, while simultaneously calming Liver Yang and clearing mild Deficiency Heat that disturbs the eyes, thereby restoring proper nourishment to the visual system from the ground up.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly sweet and slightly bitter, with sour and astringent undertones. Sweet to nourish and tonify, bitter to gently clear Heat, sour to astringently preserve Essence.

Channels Entered

Ingredients

12 herbs

The herbs that make up Ming Mu Di Huang Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 12 - 24g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Ming Mu Di Huang Wan

Strongly enriches Kidney Yin and nourishes Liver Blood, providing the root-level replenishment of Yin and Essence that the eyes depend on for moisture and clear vision.
Deputies — Assists and enhances the King
Shan Zhu Yu

Shan Zhu Yu

Asiatic cornelian cherry fruit

Dosage 6 - 12g
Temperature Slightly Warm
Taste Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Liver, Kidneys

Role in Ming Mu Di Huang Wan

Nourishes Liver and Kidney Yin and restrains the leakage of Essence, reinforcing the tonifying action of Shu Di Huang while stabilizing the Liver.
Shan Yao

Shan Yao

Chinese yam

Dosage 6 - 12g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs, Kidneys

Role in Ming Mu Di Huang Wan

Tonifies the Spleen and Kidneys, stabilizing postnatal Essence production and ensuring the body can generate and transport the nourishment the eyes need.
Gou Qi Zi

Gou Qi Zi

Chinese Wolfberry Fruit

Dosage 6 - 12g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys, Lungs

Role in Ming Mu Di Huang Wan

Nourishes Liver and Kidney Yin, enriches the Essence and Blood, and directly benefits the eyes. A premier eye-nourishing herb that bridges the Kidney-tonifying base with the eye-focused therapeutic strategy.
Assistants — Supports or moderates other herbs
Ju Hua

Ju Hua

Chrysanthemum flower

Dosage 6 - 9g
Temperature Slightly Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Liver

Role in Ming Mu Di Huang Wan

Clears Liver Heat, disperses Wind from the head and eyes, and brightens the vision. Paired with Gou Qi Zi, it directs the formula's action upward to the eyes.
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 6 - 9g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Ming Mu Di Huang Wan

Nourishes and moves the Blood, ensuring adequate Blood supply to the eyes. Addresses Liver Blood deficiency, which is a key component of eye symptoms in this pattern.
Bai Shao

Bai Shao

White peony root

Dosage 6 - 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen

Role in Ming Mu Di Huang Wan

Nourishes Liver Blood, softens and restrains Liver Yang from rising, and works with Dang Gui to comprehensively address Blood deficiency affecting the eyes.
Ji Li

Ji Li

Tribulus fruit

Dosage 6 - 9g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver

Role in Ming Mu Di Huang Wan

Calms the Liver, disperses Wind, and brightens the eyes. Helps relieve eye symptoms like itching, redness, and tearing caused by Liver Wind or rising Liver Yang.
Shi Jue Ming

Shi Jue Ming

Abalone shell

Dosage 9 - 15g
Temperature Cold
Taste Salty (咸 xián)
Organ Affinity Liver
Preparation Calcined (煅). Should be decocted first for 20-30 minutes (先煎).

Role in Ming Mu Di Huang Wan

A heavy mineral substance that anchors and subdues rising Liver Yang, clears Liver Heat obstructing the vision, and directly benefits the eyes. Its weight helps pull down excess Yang that floats upward to disturb the eyes.
Mu Dan Pi

Mu Dan Pi

Tree peony root bark

Dosage 6 - 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys

Role in Ming Mu Di Huang Wan

Clears deficiency Heat from the Liver and Kidney, cools the Blood, and prevents the formula's rich tonifying herbs from generating stagnant Heat.
Fu Ling

Fu Ling

Poria

Dosage 6 - 9g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Ming Mu Di Huang Wan

Drains Dampness and supports the Spleen's transport function, preventing the rich, cloying tonifying herbs from overwhelming digestion. Helps Shan Yao strengthen the Spleen.
Envoy — Directs the formula to its target
Ze Xie

Ze Xie

Water plantain rhizome

Dosage 6 - 9g
Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Kidneys, Urinary Bladder

Role in Ming Mu Di Huang Wan

Drains Dampness and clears turbidity from the Kidneys, preventing the heavy tonifying properties of Shu Di Huang from creating congestion. Directs excess downward and out via urination.

Why This Combination Works

How the herbs in Ming Mu Di Huang Wan complement each other

Overall strategy

This formula addresses eye problems that arise from depleted Liver and Kidney Yin, where insufficient nourishment causes the eyes to become dry and vision to blur, while deficiency Heat or unchecked Liver Yang rises to further disturb them. The prescription combines deep Yin replenishment (using Liu Wei Di Huang Wan as its foundation) with Blood nourishment, Liver-calming, and eye-brightening herbs to treat both the root deficiency and the branch symptoms affecting the eyes.

King herbs

Shu Di Huang (Prepared Rehmannia) serves as the sole King herb at the highest dosage. It powerfully enriches Kidney Yin and Essence, the deep reservoir that ultimately nourishes the Liver and sustains clear vision. In TCM theory, the eyes are the opening of the Liver, and the Liver stores Blood, but the Liver in turn depends on the Kidneys for its Yin foundation. By strongly replenishing Kidney Yin, Shu Di Huang addresses the root cause of the entire pattern.

Deputy herbs

Shan Zhu Yu astringes and supplements the Liver and Kidneys, preventing Essence from leaking away and reinforcing Shu Di Huang's tonifying work. Shan Yao supports the Spleen (the source of postnatal Essence), ensuring the body can properly generate and transport nourishment. Gou Qi Zi nourishes both Liver and Kidney Yin while directly benefiting the eyes, making it an essential bridge between the formula's tonifying foundation and its eye-focused therapeutic aim.

Assistant herbs

The assistant herbs serve several distinct functions. Dang Gui and Bai Shao form a classical Blood-nourishing pair: Dang Gui tonifies and moves Blood while Bai Shao nourishes Liver Blood and softens Liver Yang, together ensuring the eyes receive adequate Blood supply (reinforcing assistants). Ju Hua, Ji Li, and Shi Jue Ming work as a group to calm and clear the Liver: Ju Hua disperses Wind-Heat from the eyes, Ji Li calms Liver Wind and brightens vision, and Shi Jue Ming anchors rising Liver Yang with its heavy nature (counteracting assistants addressing branch symptoms). Mu Dan Pi clears deficiency Heat from the Blood, and Fu Ling drains Dampness while supporting digestion. These two herbs prevent the rich tonifying ingredients from generating pathological byproducts like stagnant Heat or Dampness (restraining assistants).

Envoy herbs

Ze Xie directs turbidity and excess fluids downward and out through urination, complementing Fu Ling in preventing the cloying nature of Shu Di Huang from congesting the Kidneys. Together with Fu Ling and Mu Dan Pi, it maintains the classic "three supplement, three drain" balance inherited from Liu Wei Di Huang Wan.

Notable synergies

Gou Qi Zi and Ju Hua together form the famous eye-benefiting pair (as seen in Qi Ju Di Huang Wan): Gou Qi Zi nourishes from below while Ju Hua clears and lifts from above, directing the formula's action to the eyes. Dang Gui and Bai Shao together nourish Liver Blood more comprehensively than either alone, with Dang Gui moving and generating Blood while Bai Shao preserves and restrains it. The Shu Di Huang, Shan Zhu Yu, and Shan Yao trio provides the foundational "three tonifying" axis of Liu Wei Di Huang Wan, targeting Kidneys, Liver, and Spleen respectively.

How to Prepare

Traditional preparation instructions for Ming Mu Di Huang Wan

The original text instructs grinding all ingredients into a fine powder and blending with refined honey to form pills. The standard modern preparation uses honey pills (蜜丸): the herbs are finely powdered and mixed with honey to form either large honey pills (大蜜丸, each about 9g) or small honey pills. For water-honey pills (水蜜丸), take 6g per dose, twice daily. For large honey pills, take 1 pill per dose, twice daily. Pills are taken on an empty stomach with lightly salted warm water or plain warm water.

When adapted as a decoction, standard dosages can be used with approximately 400-500 mL of water, decocted for about 30 minutes. Shi Jue Ming (abalone shell) should be decocted first for 20-30 minutes before adding other herbs.

Common Modifications

How practitioners adapt Ming Mu Di Huang Wan for specific situations

Added
Zhi Mu

9-12g, clears deficiency Heat from the Kidneys

Huang Qi

6-9g, drains deficiency Fire from the lower burner

Adding Zhi Mu and Huang Bai strengthens the formula's ability to clear deficiency Fire that depletes Yin fluids and disturbs the eyes, similar to incorporating the strategy of Zhi Bai Di Huang Wan.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Ming Mu Di Huang Wan should not be used or requires extra caution

Avoid

Acute conjunctivitis (暴发火眼) with red, congested eyes, excessive discharge, and acute inflammation. This formula nourishes Yin deficiency and is not appropriate for acute excess-Heat eye conditions.

Avoid

Eye conditions caused by external Wind-Heat invasion or Damp-Heat accumulation. This formula addresses internal deficiency, not external excess pathogens.

Caution

Spleen deficiency with pronounced digestive weakness, loose stools, or poor appetite. The rich, Yin-nourishing herbs (especially Shu Di Huang) are heavy and cloying, and may further burden a weak Spleen. The formula should be modified or combined with Spleen-supporting herbs if needed.

Caution

Cold-Dampness patterns or Kidney Yang deficiency with cold extremities and clear, copious urination. This cooling, Yin-nourishing formula would worsen Yang deficiency.

Caution

Active cold or flu (common cold) with exterior symptoms. Tonifying formulas should generally be withheld until the exterior pathogen is resolved.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Dang Gui (Angelica sinensis) has mild Blood-moving properties that could theoretically stimulate uterine activity at high doses. Mu Dan Pi (Moutan bark) also mildly invigorates Blood. While the formula as a whole is gentle and primarily nourishing, it is prudent for pregnant individuals to consult a qualified practitioner before use. Not absolutely contraindicated, but not recommended for unsupervised use during pregnancy.

Breastfeeding

Generally considered safe during breastfeeding. The formula is composed of nourishing, supplementing herbs without known toxic components that would transfer in clinically significant amounts through breast milk. The mild Blood-nourishing herbs (Dang Gui, Bai Shao) may even support postpartum Blood recovery. However, the rich, cloying nature of the formula could theoretically affect digestion in those with a sensitive constitution. Consult a practitioner if any concerns arise.

Children

Children should have a proper eye examination before taking this formula to rule out other conditions. Dosage should be reduced proportionally by age and body weight, typically to one-third to one-half the adult dose for children over 6. Not typically used in very young children (under 3) without specific practitioner guidance, as the rich Yin-nourishing herbs may be difficult for immature digestive systems. If symptoms such as rapid vision decline occur, discontinue and seek immediate ophthalmological evaluation. A 4-week course is standard, with reassessment needed if no improvement is seen within one week.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Ming Mu Di Huang Wan

Anticoagulants and antiplatelet drugs: Dang Gui (Angelica sinensis) has demonstrated mild anticoagulant activity and may potentiate the effects of warfarin, heparin, aspirin, or other blood-thinning medications, increasing bleeding risk. Monitor INR if taken concurrently with warfarin.

Antihypertensive medications: Several ingredients (Mu Dan Pi, Ze Xie, Ju Hua, Shi Jue Ming) have mild blood pressure-lowering effects. Combined use with antihypertensive drugs may cause additive hypotension. Blood pressure should be monitored.

Hypoglycemic agents: Shu Di Huang and Shan Yao have been reported to have mild blood sugar-lowering properties. Diabetic patients on insulin or oral hypoglycemics should monitor blood glucose more closely when starting this formula.

Diuretics: Ze Xie and Fu Ling promote urination. Concurrent use with pharmaceutical diuretics could lead to excessive fluid loss or electrolyte imbalance.

Usage Guidance

Practical advice for getting the most out of Ming Mu Di Huang Wan

Best time to take

Best taken on an empty stomach, typically 30 minutes before meals, twice or three times daily.

Typical duration

Often taken for 4 weeks per course, with reassessment by a practitioner. May be continued for 2-3 months for chronic conditions, with periodic breaks.

Dietary advice

Avoid cold and raw foods, greasy or fried foods, and excessive spicy or pungent foods that can generate Heat or burden the Spleen. The classical source text specifically advises against eating turnips (luobo) while taking this formula, as they are thought to counteract the tonifying action of the herbs. Favor dark leafy greens, berries, goji berries, black sesame seeds, and other foods that nourish Liver Blood and Kidney Yin. Adequate hydration supports the Yin-nourishing actions of the formula.

Ming Mu Di Huang Wan originates from Shěn Shì Yáo Hán (审视瑶函, Discerning Patterns and Guiding Remedies for the Eyes) by Fù Rényǔ (傅仁宇) Míng dynasty, 1644 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Ming Mu Di Huang Wan and its clinical use

《审视瑶函》 (Shen Shi Yao Han, Scrutiny of the Precious Jade Case) by Fu Renyu (傅仁宇), Ming Dynasty:

The source text describes this formula as a supplementing and nourishing prescription for the Liver and Kidneys that brightens the eyes. It states that the formula treats eye disorders arising from Liver and Kidney Yin deficiency with deficiency Fire flaring upward, causing dry and gritty eyes, sensitivity to light, blurred vision, and tearing in wind.

Classical TCM ophthalmology principle:

「五脏六腑之精气,皆上注于目」 — "The essential Qi of all five Zang and six Fu organs ascends and gathers in the eyes."

This passage from the Huang Di Nei Jing (Ling Shu) underpins the entire rationale for treating eye disorders through organ supplementation. Because all five Zang organs contribute their refined substances to nourish the eyes, the eyes are considered a convergence point for the body's vital essence. When the Liver and Kidneys become depleted, the eyes lose their nourishment and vision deteriorates.

Historical Context

How Ming Mu Di Huang Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Ming Mu Di Huang Wan originates from the Shen Shi Yao Han (《审视瑶函》, Scrutiny of the Precious Jade Case), a renowned ophthalmology text written by the Ming Dynasty physician Fu Renyu (傅仁宇, courtesy name Yunke 允科). First published in 1644, the text is a comprehensive six-volume work on eye diseases that synthesized earlier ophthalmological knowledge with Fu's own extensive clinical experience spanning over 30 years. It remains one of the most influential classical TCM ophthalmology texts.

The modern standardized version of Ming Mu Di Huang Wan, as codified in the Chinese Pharmacopoeia (first included in 1963 and refined in the 2000 edition), is built upon Qi Ju Di Huang Wan (itself an extension of Liu Wei Di Huang Wan with Gou Qi Zi and Ju Hua), with the further addition of Dang Gui, Bai Shao, Ji Li (Tribulus), and Shi Jue Ming (calcined Haliotis shell). This makes it an "upgraded" version of Qi Ju Di Huang Wan, with stronger Blood-nourishing capacity and additional Liver-calming, vision-clearing power. Some historical versions of the formula contain slightly different compositions (including Chai Hu, Wu Wei Zi, or Sheng Di Huang alongside Shu Di Huang), reflecting the multiple lineages of formulas bearing this name across different classical texts.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Ming Mu Di Huang Wan

1

Ming-Mu-Di-Huang-Pill Activates SQSTM1 via AMPK-Mediated Autophagic KEAP1 Degradation and Protects RPE Cells from Oxidative Damage (In vitro/in vivo study, 2022)

Chen X, Zhu Y, Shi X, Zuo J, Hu T, Wu H, Xia Y, Shi W, Wei W. Oxidative Medicine and Cellular Longevity. 2022; 2022: 5851315.

This laboratory study investigated how MMDH pill protects retinal pigment epithelium (RPE) cells from oxidative damage, which is a key factor in age-related macular degeneration (AMD). Results showed the formula increased cell viability, restored antioxidant enzyme activity, and reduced reactive oxygen species through AMPK-mediated autophagy pathways. The study provides molecular evidence for the formula's traditional use in protecting vision, though clinical trials in humans are still needed.

DOI
2

Evidence-based Practice Guideline of Chinese Herbal Medicine for Primary Open-Angle Glaucoma (Guideline, 2018)

Li F, Yang G, Zhang L, et al. Journal of Evidence-Based Medicine. 2018; 11(1): 30-42.

This evidence-based clinical practice guideline for treating primary open-angle glaucoma with Chinese herbal medicine included a review of Mingmu Dihuang Wan. The guideline gave MMDH a 'slightly recommended' rating for the pattern of Liver and Kidney Yin deficiency in glaucoma, noting it is low cost, easily accessible, and without reported adverse effects. Evidence quality was limited, and stronger clinical trials were called for.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.