Sang Ju Yin

Mulberry Leaf and Chrysanthemum Decoction · 桑菊飲

Also known as: Morus and Chrysanthemum Combination, Mulberry and Chrysanthemum Drink, Sang Ju Yin

A gentle, cooling formula used for early-stage colds and respiratory infections marked by cough as the main symptom, with mild fever, slight thirst, and a floating rapid pulse. It gently clears Wind-Heat from the Lungs and restores their natural ability to regulate breathing and stop coughing.

Origin Wēn Bìng Tiáo Biàn (温病条辨, Systematic Differentiation of Warm Diseases) by Wú Jūtōng (吴鞠通) — Qīng dynasty, 1798 CE
Composition 8 herbs
Sang Ye
King
Sang Ye
Ju Hua
King
Ju Hua
Bo He
Deputy
Bo He
Xing Ren
Deputy
Xing Ren
Jie Geng
Deputy
Jie Geng
Lian Qiao
Assistant
Lian Qiao
Lu Gen
Assistant
Lu Gen
Gan Cao
Envoy
Gan Cao
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Sang Ju Yin is designed to correct these specific patterns.

Why Sang Ju Yin addresses this pattern

This is the primary pattern addressed by Sang Ju Yin. Wind-Heat enters the body through the nose and mouth, lodging in the Lung's network vessels and disrupting its descending and disseminating functions. The Lung's failure to properly direct Qi downward produces cough as the main symptom. Because the invasion is still at an early, superficial stage, the Heat is mild: the fever is slight, the thirst is only mild, and the tongue coat remains thin and white. Sang Ye and Ju Hua directly scatter Wind-Heat from the Lung network vessels, while Bo He assists the release of the pathogen outward through the exterior. Xing Ren and Jie Geng restore the Lung's up-and-down Qi movement to stop the cough. Lian Qiao clears residual Heat and toxins, and Lu Gen replenishes the fluids that early-stage Heat has begun to consume. The formula's intentionally light dosage makes it perfectly calibrated for this mild stage of Wind-Heat, avoiding the risk of over-chilling and damaging the body's Qi.

A practitioner would look for one or more of these signs

Hypochondrial Pain That Is Worse On Coughing And Breathing

Dominant symptom; may be dry or with scant thin white or slightly yellow phlegm

Fever

Mild or low-grade; the patient may not feel significantly hot

Thirst

Slight thirst (微渴), indicating early fluid consumption by Heat

Sore Throat

Mild scratchy or slightly sore throat

Headaches

Mild headache from Wind-Heat rising to the head

Red Eyes

Possible redness or discomfort of the eyes from Wind-Heat affecting the upper body

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Sang Ju Yin when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, the common cold is understood as an invasion of the body's exterior defensive layer (Wei Qi) by environmental pathogens, most commonly Wind combined with either Cold or Heat. In the Wind-Heat type, the pathogen enters through the nose and mouth and attacks the Lung system, which governs the skin surface, breathing, and the body's outer defenses. When the Lung is impaired by Wind-Heat, it loses its ability to properly regulate Qi flow, leading to cough, a slight fever as the body fights the invader, a mildly sore or scratchy throat, and slight thirst as the warmth begins to consume fluids.

Why Sang Ju Yin Helps

Sang Ju Yin is specifically calibrated for the mild Wind-Heat type of common cold where cough is the main complaint. Sang Ye and Ju Hua gently disperse the Wind-Heat pathogen from the Lungs and upper body. Bo He helps release the pathogen outward through the skin. Xing Ren and Jie Geng restore normal Lung Qi movement to stop the cough, while Lian Qiao clears residual Heat and Lu Gen replenishes fluids. The formula's notably light dosing is intentional: because the illness is mild, heavy medicines would risk driving the pathogen deeper or over-cooling the body. This makes it an ideal first-line formula at the very onset of a Wind-Heat cold.

Also commonly used for

Upper Respiratory Tract Infections

Mild cases with cough as the leading symptom

Influenza

Early stage with mild fever and prominent cough

Pneumonia

Very early or mild cases with Wind-Heat pattern

Acute Tonsillitis

Mild cases with Wind-Heat pattern; often modified with Niu Bang Zi

Keratitis

Wind-Heat type with redness and irritation of the eyes

What This Formula Does

Every TCM formula has a specific set of actions — here's what Sang Ju Yin does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Sang Ju Yin is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Sang Ju Yin performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Sang Ju Yin works at the root level.

Sang Ju Yin addresses the earliest and mildest stage of a warm-pathogen invasion of the Lungs. In TCM, warm (Heat-type) pathogens enter the body through the nose and mouth and, as the classical teaching states, "first attack the Lungs." When Wind-Heat settles in the upper body, it disrupts the Lung's two essential functions: dispersing Qi outward and downward (called the Lung's "dispersing and descending"). When dispersing fails, Qi stagnates in the chest, producing cough. Because the invasion is still superficial, the body mounts only a mild defensive response, so fever is low-grade or even absent, and only slight thirst appears (indicating that Heat has just barely begun to damage fluids).

The key diagnostic picture is cough as the dominant symptom, with mild or no fever, slight thirst, a thin white tongue coating, and a floating, rapid pulse. Wu Jutong described the mechanism precisely: "Cough means Heat is injuring the Lung network vessels; the body is not very hot because the illness is not severe; thirst is slight because the Heat is not intense." The pathology sits between the exterior (the body's surface defense layer) and the Lung organ itself, in what Wu Jutong termed the "Lung network" (肺络). This is lighter than a full Defensive-level (Wei) pattern (which Yin Qiao San addresses) but already involves functional impairment of the Lung.

If this mild condition is wrongly treated with warming, acrid herbs (as was common with Xing Su San in Wu Jutong's era), the Heat is not cleared and the Lung's precious fluids are "scorched," potentially leading to chronic cough or even consumptive wasting. The formula's design reflects the Wen Bing principle of "treating the Upper Burner like a feather — only light [medicines] can lift it" (治上焦如羽,非轻不举), using gentle, cool, and light ingredients rather than heavy or harsh ones.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly acrid (pungent) and slightly sweet with a mild bitter note — acrid to disperse Wind-Heat, sweet to gently moisten and protect fluids, bitter to descend and settle Lung Qi.

Target Organs

Channels Entered

Lung Liver

Ingredients

8 herbs

The herbs that make up Sang Ju Yin, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Sang Ye

Sang Ye

Mulberry leaf

Dosage 7.5g
Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Liver

Role in Sang Ju Yin

Sweet, bitter, and cool in nature, Sang Ye is the primary herb in this formula. It excels at dispersing Wind-Heat from the upper body, particularly from the Lung network vessels (肺络). It clears Lung Heat and stops coughing, directly addressing the core symptom of this pattern.
Ju Hua

Ju Hua

Chrysanthemum flower

Dosage 3g
Temperature Slightly Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Liver

Role in Sang Ju Yin

Pungent, sweet, and slightly cold, Ju Hua disperses Wind-Heat from the upper burner, clears the head and eyes, and assists the Lungs in their descending function. Working together with Sang Ye, the two herbs are light, aromatic, and upward-moving, forming a synergistic pair that excels at scattering Wind-Heat from the Lungs. The yellow variety (huang ju hua) is traditionally preferred for this formula due to its stronger exterior-releasing action.
Deputies — Assists and enhances the King
Bo He

Bo He

Mint herb

Dosage 2.5g
Temperature Cool
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Lungs, Liver
Preparation Added in the last 3-5 minutes of decoction (后下) to preserve its volatile aromatic oils.

Role in Sang Ju Yin

Pungent and cool, Bo He reinforces the ability of the King herbs to disperse Wind-Heat from the exterior and the upper body. It also benefits the head, eyes, and throat, helping to release the pathogen outward through the skin.
Xing Ren

Xing Ren

Bitter apricot kernel

Dosage 6g
Temperature Slightly Warm
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Large Intestine

Role in Sang Ju Yin

Bitter and slightly warm, Xing Ren descends Lung Qi. When paired with Jie Geng, the two form a classic combination: one opens the Lungs upward while the other directs Qi downward. This restores the Lung's natural rising-and-descending rhythm, which is the key mechanism for stopping cough.
Jie Geng

Jie Geng

Platycodon root

Dosage 6g
Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs

Role in Sang Ju Yin

Bitter and pungent, Jie Geng opens and lifts Lung Qi, promoting the Lung's disseminating function. Paired with Xing Ren, the one-up-one-down combination restores the Lung's normal Qi movement and relieves cough. It also guides the other herbs upward to the upper body where the pathogen resides.
Assistants — Supports or moderates other herbs
Lian Qiao

Lian Qiao

Forsythia fruit

Dosage 5g
Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Heart, Small Intestine

Role in Sang Ju Yin

Bitter and slightly cold, Lian Qiao clears Heat and resolves toxins from the upper burner. It also has a mild exterior-releasing quality that helps vent the pathogen outward, reinforcing the formula's overall Wind-Heat dispersing action.
Lu Gen

Lu Gen

Reed rhizome

Dosage 6g
Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Lungs, Stomach

Role in Sang Ju Yin

Sweet and cold, Lu Gen clears Heat and generates body fluids. It addresses the mild thirst that accompanies this pattern, where early-stage Heat has begun to slightly damage the Lung's fluids. Its gentle moistening quality prevents the formula from being too drying.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 2.5g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Sang Ju Yin

Sweet and neutral (raw form used here), Gan Cao harmonizes all the herbs in the formula. Combined with Jie Geng, it also benefits the throat and helps relieve cough. Its mild Heat-clearing action supports the overall treatment strategy.

Why This Combination Works

How the herbs in Sang Ju Yin complement each other

Overall strategy

This formula addresses early-stage Wind-Heat that has entered through the nose and mouth and lodged in the Lung network vessels, disrupting the Lung's descending and disseminating functions and causing cough as the dominant symptom. The strategy, described by Wu Jutong as "pungent-cool with a touch of bitter" (辛凉微苦), uses light, aromatic herbs in small doses to gently disperse Heat from the upper body while restoring normal Lung Qi movement. This embodies his principle that "treating the upper burner is like handling a feather: only something light can lift it" (治上焦如羽,非轻不举).

King herbs

Sang Ye (Mulberry Leaf) and Ju Hua (Chrysanthemum) serve jointly as King herbs. Sang Ye is sweet, bitter, and cool, and is particularly noted for its affinity to the Lung network vessels, where it disperses Wind-Heat and stops coughing. Ju Hua is pungent, sweet, and slightly cold, excelling at scattering Wind-Heat from the upper burner and clearing the head and eyes. Together they are light and aromatic, rising naturally to the upper body to address the core pathology of Wind-Heat lodged in the Lungs.

Deputy herbs

Three herbs serve as Deputies, reinforcing the Kings from two directions. Bo He (Mint) is pungent and cool, strengthening the Kings' ability to release Wind-Heat from the exterior surface. Xing Ren (Apricot Kernel) and Jie Geng (Platycodon Root) form a classic paired combination: Jie Geng opens the Lung Qi upward while Xing Ren directs it downward. This one-up-one-down mechanism (一宣一降) restores the Lung's natural rhythm of dissemination and descent, which is the fundamental approach to stopping cough.

Assistant herbs

Lian Qiao (Forsythia) is a reinforcing assistant that clears Heat and resolves toxins from the upper burner. It also has a mild venting quality that aids the formula's exterior-releasing action. Lu Gen (Reed Rhizome) is also a reinforcing assistant that clears Heat and generates fluids, addressing the mild thirst present when early-stage Heat begins to consume the body's fluids.

Envoy herbs

Gan Cao (Licorice Root) in its raw form harmonizes all herbs in the formula. When paired with Jie Geng, it directs the formula's action to the throat and upper respiratory tract, while also clearing mild Heat and relieving cough.

Notable synergies

The Sang Ye and Ju Hua pairing is the heart of this formula. Both enter the Lung and Liver channels and are light, aromatic substances that naturally rise to the head and upper body. Their combined effect on dispersing Lung Wind-Heat is greater than either alone. The Jie Geng and Xing Ren pairing is one of the most commonly used drug combinations in TCM for regulating Lung Qi and treating cough. The entire formula uses remarkably small doses, totalling only about 39 grams, which keeps it light and prevents over-cooling of a pattern that is still relatively mild.

How to Prepare

Traditional preparation instructions for Sang Ju Yin

The classical method calls for using approximately 400 ml (two cups) of water, bringing it to a boil and simmering until reduced to approximately 200 ml (one cup). Take warm, twice daily. Because all ingredients in this formula are light, aromatic herbs (leaves, flowers, and thin stems), the decoction should not be boiled for a long time. A total boiling time of 15 to 20 minutes is sufficient. Prolonged boiling will cause the volatile aromatic compounds to evaporate, weakening the formula's ability to disperse Wind-Heat. Bo He (mint) should ideally be added in the last 3 to 5 minutes of decoction.

Common Modifications

How practitioners adapt Sang Ju Yin for specific situations

Added
Shi Gao

15-30g, clears Qi-level Heat

Zhi Mu

6-10g, clears Heat and nourishes Yin

When Heat deepens from the Lung's surface to the Qi level, the original light formula is insufficient. Shi Gao and Zhi Mu strongly clear Qi-level Heat while protecting fluids, following Wu Jutong's original modification instructions.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Sang Ju Yin should not be used or requires extra caution

Avoid

Wind-Cold patterns: This formula is cooling in nature and designed exclusively for Wind-Heat or warm-pathogen conditions. Using it for cough due to Wind-Cold invasion (with chills, clear nasal discharge, thin white tongue coating, and tight pulse) will worsen the condition.

Avoid

Severe high fever with strong interior Heat: As an 'acrid-cool light formula,' Sang Ju Yin is intended for mild, early-stage Wind-Heat. When Heat has already entered deeper levels (the Qi, Ying, or Blood levels) with high fever, severe thirst, or red/crimson tongue, the formula is too light and must be replaced or substantially modified with stronger Heat-clearing agents.

Caution

Yin-deficient or chronic dry cough without external pathogen: The formula is designed for acute external invasion. Chronic cough from internal Yin deficiency or Lung dryness without an external Wind-Heat component requires nourishing, not dispersing, treatment.

Caution

Qi-deficient or Yang-deficient constitutions: People with underlying Qi or Yang weakness (who tire easily, feel cold, or have pale complexion) should use this formula with caution and for short durations only, as its cool, dispersing nature may further weaken the body's Qi.

Caution

Spleen and Stomach deficiency with loose stools: The cool nature of most ingredients may aggravate digestive weakness. Use with caution or add Spleen-supporting herbs if needed.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe for short-term use in pregnancy under professional guidance. All eight herbs in the formula are mild and light in nature, and none are classically listed as prohibited during pregnancy. Clinical reports exist of Sang Ju Yin being used for pregnant women with Wind-Heat coughs. However, Xing Ren (apricot kernel) contains trace amygdalin, which in excessive doses could theoretically pose concerns. At the standard low dose in this formula (6g), this is not typically considered a risk. Pregnant individuals should always consult a qualified practitioner rather than self-prescribing.

Breastfeeding

Generally considered compatible with breastfeeding. The herbs in this formula are light and mild, and there are no classically documented concerns about transfer through breast milk affecting the nursing infant. Gan Cao (licorice) in very high doses could theoretically affect fluid balance, but the dose in this formula (2.5g) is minimal. The formula's cooling nature is appropriate for acute short-term use. Breastfeeding mothers should still consult a practitioner, especially if the infant shows any signs of digestive disturbance (such as loose stools) while the mother is taking the formula.

Children

Sang Ju Yin is widely used in pediatric practice in China and is considered appropriate for children with Wind-Heat coughs. Dosage should be reduced according to age and body weight: - Infants under 1 year: typically 1/4 to 1/3 of the adult dose - Children 1–5 years: approximately 1/3 to 1/2 of the adult dose - Children 6–12 years: approximately 1/2 to 2/3 of the adult dose The formula's light, gentle nature makes it particularly suited for children, whose constitutions are delicate. Classical case literature includes pediatric applications, such as Pu Fuzhou's treatment of a child with adenovirus pneumonia using modified Sang Ju Yin. The decoction should not be boiled for long, as the volatile aromatic components are easily lost. For young children who resist the taste, the decoction may be given in smaller, more frequent doses.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Sang Ju Yin

Gan Cao (Licorice root): Although present in a very small dose (2.5g), Gan Cao contains glycyrrhizin, which at higher or prolonged doses can cause potassium depletion and sodium retention. In this formula's typical short-term, low-dose use, clinically significant interactions are unlikely. However, if a patient is concurrently taking potassium-depleting diuretics, digoxin, corticosteroids, or antihypertensive medications, practitioners should be aware of this theoretical interaction and monitor accordingly.

Xing Ren (Apricot kernel): Contains small amounts of amygdalin, which can release hydrogen cyanide during metabolism. At standard formula doses (6g) the amount is well below toxic thresholds. However, caution is warranted if the patient is taking other cyanogenic compounds or medications metabolized through similar pathways.

Lian Qiao (Forsythia fruit): Has demonstrated mild anticoagulant properties in some pharmacological studies. Patients taking warfarin or other anticoagulant/antiplatelet drugs should inform their practitioner, though the low dose in this formula makes significant interaction unlikely.

General note: Because this formula is typically used for only 3–7 days for acute conditions, the risk of clinically meaningful drug interactions is low. Patients on any regular medications should always disclose this to their prescribing practitioner.

Usage Guidance

Practical advice for getting the most out of Sang Ju Yin

Best time to take

Twice daily, warm, 30–60 minutes after meals. Do not over-boil the decoction — a brief simmering preserves the volatile aromatic compounds.

Typical duration

Acute use: 3–7 days. As an acrid-cool light formula for early-stage conditions, it should resolve symptoms quickly; reassess if no improvement within 3 days.

Dietary advice

While taking this formula, favor light, easily digestible foods such as congee (rice porridge), clear soups, steamed vegetables, and pears (which moisten the Lungs). Drink plenty of warm water to support the formula's fluid-generating action. Avoid greasy, fried, or heavy foods that can generate Dampness and Phlegm, obstructing the Lung's function. Avoid spicy, heating foods (chili, lamb, ginger in large amounts, fried snacks) that could add Heat and counteract the formula's cooling action. Also avoid cold, raw, and iced foods and drinks, which can impair the Stomach's digestive function during illness. Alcohol should be avoided as it generates Heat and Dampness.

Sang Ju Yin originates from Wēn Bìng Tiáo Biàn (温病条辨, Systematic Differentiation of Warm Diseases) by Wú Jūtōng (吴鞠通) Qīng dynasty, 1798 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Sang Ju Yin and its clinical use

Original condition statement from Wen Bing Tiao Bian (《温病条辨》), Upper Burner Chapter:

「太阴风温,但咳,身不甚热,微渴者,辛凉轻剂桑菊饮主之。」

"For Wind-Warmth of the Taiyin [Lung], presenting with only cough, body heat that is not severe, and slight thirst, the acrid-cool light formula Sang Ju Yin governs."


Wu Jutong's commentary on the formula's design principle, Wen Bing Tiao Bian:

「此辛甘化风,辛凉微苦之方也。盖肺为清虚之脏,微苦则降,辛凉则平,立此方所以避辛温也。」

"This is a formula of acrid-sweet [to disperse] Wind and acrid-cool with slight bitterness. The Lung is a clear, delicate organ: slight bitterness causes descending, acrid-cool brings balance. This formula was created specifically to avoid using acrid-warm [methods for cough]."


Wu Jutong's warning against misuse, Wen Bing Tiao Bian:

「风温咳嗽,虽系小病,常见误用辛温重剂,销铄肺液,致久咳成痨者,不一而足。」

"Although Wind-Warmth cough is a minor illness, one frequently sees cases where the mistaken use of acrid-warm heavy formulas scorches the Lung fluids, leading to chronic cough that develops into consumption [tuberculosis-like wasting] — such cases are too numerous to count."

Historical Context

How Sang Ju Yin evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Sang Ju Yin was created by Wu Jutong (吴鞠通, 1758–1836), one of the four great masters of the Warm Disease (Wen Bing) school in the Qing Dynasty. It first appeared in his landmark work Wen Bing Tiao Bian (温病条辨, "Systematic Differentiation of Warm Diseases"), completed around 1798 and first published in 1813. Wu Jutong built upon the theoretical foundations laid by Ye Tianshi (叶天士), who had formulated the principle "warm pathogens attack from above, first striking the Lungs" (温邪上受,首先犯肺), but whose own prescriptions were scattered across clinical case records rather than organized systematically.

Wu Jutong's great innovation was organizing warm disease treatment into a graded system of acrid-cool formulas matched to disease severity: Sang Ju Yin as the "acrid-cool light formula" (辛凉轻剂) for the mildest cases, Yin Qiao San as the "acrid-cool balanced formula" (辛凉平剂) for moderate cases, and Bai Hu Tang as the "acrid-cool heavy formula" (辛凉重剂) for severe Qi-level Heat. This systematic layering was a major contribution to clinical medicine. Wu Jutong specifically warned practitioners of his time against the widespread habit of using the warming formula Xing Su San for all coughs regardless of Heat or Cold type, noting that this error frequently led to chronic lung damage.

The famous physician Pu Fuzhou (蒲辅周, 1888–1975) later demonstrated the formula's effectiveness in modern clinical settings, including a notable case of adenovirus pneumonia in a child, where two doses of modified Sang Ju Yin produced sweating and fever reduction, validating Wu Jutong's principle of treating the Upper Burner with light, feather-like medicines. During the 2009 H1N1 influenza pandemic and again during COVID-19, Sang Ju Yin was included in several provincial TCM treatment guidelines in China for early-stage respiratory infections with mild fever and cough.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Sang Ju Yin

1

Anti-inflammatory active component screening in Sang Ju Yin using UPLC/Q-TOF and NF-κB reporter gene assay (Laboratory study, 2016)

Jiang M, et al. Tianjin Journal of Traditional Chinese Medicine (中草药), 2016, 47(8).

Researchers used advanced chromatography combined with a cell-based inflammation assay to identify 16 anti-inflammatory compounds in Sang Ju Yin. Five came from chrysanthemum, six from licorice, four from forsythia, and one from platycodon. Several compounds including caffeic acid, glycyrrhizic acid, and forsythoside A were shown to inhibit the NF-κB inflammatory pathway in human bronchial epithelial cells, providing a molecular basis for the formula's traditional use in treating respiratory inflammation.

Link
2

Network pharmacology analysis of the targets and mechanisms of Sang Ju Yin for COVID-19 treatment (Computational study, 2022)

Li I. Journal of Student Research, 2022, 11(4).

This network pharmacology study identified potential molecular targets through which Sang Ju Yin may act against COVID-19. The analysis found that active ingredients including luteolin, kaempferol, and quercetin may bind to and inhibit ACE2 and the 3CL protease involved in viral entry and replication. Key gene targets identified were AKT1, IL-6, and MAPK3, suggesting the formula may regulate inflammatory and immune pathways relevant to COVID-19. This is a computational prediction study and has not been validated in clinical trials.

Link

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.