Yin Qiao San

Honeysuckle and Forsythia Powder · 銀翹散

Also known as: Yin Qiao Jie Du San (銀翹解毒散), Yin Qiao Jie Du Wan (銀翹解毒丸, pill form), Yin Qiao Jie Du Pian (銀翹解毒片, tablet form)

A classic formula for the early stages of colds and flu caused by Wind-Heat, with symptoms like fever, sore throat, headache, thirst, and cough. It works by gently releasing the exterior to expel the pathogen while clearing heat and resolving toxicity, targeting the upper respiratory system. One of the most widely used formulas in Chinese medicine for acute infections with heat signs.

Origin Wen Bing Tiao Bian (Systematic Differentiation of Warm Diseases) by Wu Jutong (吴鞠通) — Qīng dynasty, 1798 CE
Composition 10 herbs
Jin Yin Hua
King
Jin Yin Hua
Lian Qiao
King
Lian Qiao
Bo He
Deputy
Bo He
Niu Bang Zi
Deputy
Niu Bang Zi
Jing Jie
Deputy
Jing Jie
Dan Dou Chi
Deputy
Dan Dou Chi
Jie Geng
Assistant
Jie Geng
Dan Zhu Ye
Assistant
Dan Zhu Ye
+2
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Yin Qiao San is designed to correct these specific patterns.

Why Yin Qiao San addresses this pattern

When a Wind-Heat pathogen enters through the nose and mouth, it first attacks the Lungs and the body's defensive (Wei) layer. The defensive Qi becomes constrained, losing its ability to properly regulate the opening and closing of the pores. This produces fever with mild chills, headache, and absent or incomplete sweating. Because the Lungs govern the throat and are connected to the nose, the pathogen rising upward causes sore throat and cough. The warm nature of the pathogen begins to consume body fluids, producing thirst.

Yin Qiao San is precisely designed for this scenario. Jin Yin Hua and Lian Qiao clear the heat-toxin accumulating in the Lungs while dispersing the pathogen from the surface. Bo He, Niu Bang Zi, Jing Jie, and Dan Dou Chi work together to open the pores and push the trapped pathogen outward. Jie Geng restores the Lung's descending and dispersing function, while Lu Gen, Dan Zhu Ye, and Gan Cao protect fluids and soothe the throat. The formula treats both the surface constraint and the underlying heat simultaneously.

A practitioner would look for one or more of these signs

Fever

Fever with mild aversion to wind and cold

Sore Throat

Red, swollen, painful throat

Headaches

Headache from Wind-Heat rising

Thirst

Thirst from heat damaging fluids

Absence Of Sweating

No sweating or incomplete sweating

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Yin Qiao San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, influenza is understood as an invasion by seasonal warm-pathogen or epidemic toxin (温毒) that enters through the nose and mouth and first attacks the Lungs and defensive Qi. The body's defensive layer becomes constrained as it tries to fight off the pathogen, producing fever. Because the pathogen is warm in nature (as opposed to cold), the fever is prominent while aversion to cold is mild. The heat damages fluids (causing thirst), inflames the throat (causing sore throat), and disrupts the Lung's dispersing function (causing cough). The tongue tip turns red, reflecting heat in the Upper Burner, and the pulse becomes floating and rapid, indicating the pathogen is still at the surface level.

Why Yin Qiao San Helps

Yin Qiao San directly targets the pathomechanism of early-stage influenza. Jin Yin Hua and Lian Qiao clear the heat-toxin that the influenza pathogen generates, while Bo He, Jing Jie, and Dan Dou Chi release the constrained exterior to help the body expel the pathogen. Niu Bang Zi and Jie Geng specifically address the sore, swollen throat that is common in flu. Lu Gen and Dan Zhu Ye protect body fluids from being consumed by the fever. Modern pharmacological research has shown that the formula's compounds can inhibit viral replication and modulate immune responses, which aligns with its traditional use. The formula is most effective when taken at the very first signs of illness, before the pathogen moves deeper into the body.

Also commonly used for

Pharyngitis

Acute pharyngitis

Bronchitis

Acute bronchitis at early stage

Measles

Early-stage measles with incomplete eruption

Lumps

Mumps (epidemic parotitis)

Pneumonia

Early-stage pneumonia with Wei-level pattern

Viral Conjunctivitis

Acute conjunctivitis from Wind-Heat

Urticaria

Acute urticaria triggered by Wind-Heat

What This Formula Does

Every TCM formula has a specific set of actions — here's what Yin Qiao San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Yin Qiao San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Yin Qiao San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Yin Qiao San works at the root level.

Yin Qiao San addresses the earliest stage of a warm-pathogen disease (温病 Wen Bing), when a Heat-natured external pathogen has just entered the body through the nose and mouth and lodged at the Wei (defensive) level of the Lungs. In TCM theory, the Wei level is the body's outermost energetic layer, controlled by the Lungs, which governs the opening and closing of the pores and the circulation of protective Qi just beneath the skin.

When a Wind-Heat pathogen invades, it disrupts the Lungs' control over the body's surface. The defensive Qi becomes congested and cannot circulate properly, leading to fever and a mild sensation of chills (much less pronounced than in a cold-type illness). Because the pathogen is warm in nature, it also begins to scorch the body's fluids, causing thirst and a dry throat. The Heat rising upward and pressing on the throat produces soreness and redness. The Lungs' normal descending function is disrupted, producing cough. The tongue tip turns red (indicating Heat reaching the Heart area via the Lung connection), while the coating remains thin and white or slightly yellow, confirming the pathogen is still at the surface level and has not yet penetrated deeper.

The critical clinical window for Yin Qiao San is precisely this moment: Heat is present but still superficial, the body's deeper Yin fluids have not yet been seriously damaged, and the pathogen can still be pushed outward. If treatment is delayed or inappropriate (such as using warming, pungent herbs meant for cold-type illness), the Heat can drive inward toward the Qi, Ying (nutritive), or Blood levels, creating a much more serious and harder-to-treat condition. The formula works by opening the surface with light, aromatic, acrid-cool herbs that vent the Heat outward while simultaneously clearing the toxic Heat and protecting fluids from being consumed.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly acrid and slightly bitter with a sweet undertone. The acrid flavor disperses the exterior pathogen, the bitter taste clears Heat and directs it downward, and the sweetness harmonizes and protects the fluids.

Channels Entered

Ingredients

10 herbs

The herbs that make up Yin Qiao San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Jin Yin Hua

Jin Yin Hua

Honeysuckle flower

Dosage 9 - 15g
Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Lungs, Heart, Stomach, Large Intestine

Role in Yin Qiao San

Acrid, cool, and aromatic. Clears heat and resolves toxicity while lightly dispersing exterior Wind-Heat. As the primary King herb, it addresses both the surface pathogen and the underlying heat-toxin that characterises warm-pathogen diseases.
Lian Qiao

Lian Qiao

Forsythia fruit

Dosage 9 - 15g
Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Heart, Small Intestine

Role in Yin Qiao San

Acrid, bitter, and slightly cold. Clears heat, resolves toxicity, and disperses Wind-Heat from the exterior. Paired with Jin Yin Hua as co-King, it reinforces both the exterior-releasing and heat-clearing actions and helps disperse clumped heat-toxin.
Deputies — Assists and enhances the King
Bo He

Bo He

Peppermint herb

Dosage 3 - 6g
Temperature Cool
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Lungs, Liver
Preparation Added in the last 5 minutes of decoction (后下)

Role in Yin Qiao San

Acrid and cool. Disperses Wind-Heat, clears the head and eyes, and benefits the throat. Supports the King herbs in releasing the exterior and directing the formula's action upward to the head and throat.
Niu Bang Zi

Niu Bang Zi

Burdock fruit

Dosage 6 - 9g
Temperature Cold
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Stomach

Role in Yin Qiao San

Acrid, bitter, and cold. Disperses Wind-Heat, benefits the throat, and promotes the expression of skin rashes. Complements the King herbs by specifically targeting sore throat and swollen glands.
Jing Jie

Jing Jie

Schizonepeta herb

Dosage 3 - 6g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Lungs, Liver

Role in Yin Qiao San

Acrid and slightly warm. Opens the pores and helps expel the pathogen from the exterior. Although slightly warm, it is mild and non-drying. Used here by the method of 'borrowing its nature' (去性取用): its warm-dispersing power enhances exterior release without contradicting the overall cooling strategy.
Dan Dou Chi

Dan Dou Chi

Fermented soybean

Dosage 3 - 6g
Temperature Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Stomach

Role in Yin Qiao San

Acrid and slightly warm. Releases the exterior and relieves irritability. Like Jing Jie, it is mildly warm and helps push the pathogen outward through the surface. Its warmth is restrained by the surrounding cool herbs.
Assistants — Supports or moderates other herbs
Jie Geng

Jie Geng

Balloon flower root

Dosage 3 - 6g
Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs

Role in Yin Qiao San

Bitter and acrid. Opens and disseminates Lung Qi, benefits the throat, and directs the actions of the other herbs upward to the Upper Burner. Paired with Gan Cao, it specifically addresses sore throat.
Dan Zhu Ye

Dan Zhu Ye

Lophatherum herb

Dosage 3 - 6g
Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Stomach, Small Intestine

Role in Yin Qiao San

Sweet, bland, and cold. Clears heat from the Upper Burner and relieves restlessness. Gently generates fluids to counter the drying effect of the exterior-releasing herbs.
Lu Gen

Lu Gen

Reed rhizome

Dosage 15 - 30g
Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Lungs, Stomach
Preparation Use fresh (鲜芦根) when available; in the original formula it is decocted first to make the cooking liquid

Role in Yin Qiao San

Sweet and cold. Clears heat and generates fluids to protect body fluids from being damaged by the warm pathogen. In the original formula, fresh Lu Gen decoction is used as the cooking medium for the powder, underscoring its role in preserving fluids.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Yin Qiao San

Sweet and neutral-to-cool (in raw form). Harmonises all the herbs in the formula, clears heat and resolves toxicity, and paired with Jie Geng specifically soothes sore throat.

Why This Combination Works

How the herbs in Yin Qiao San complement each other

Overall strategy

This formula addresses the early stage of a warm-pathogen (Wen Bing) invasion, when the pathogen is lodged at the body's defensive (Wei) layer, blocking the Lungs and Upper Burner. The strategy is to gently release the exterior using acrid-cool herbs while simultaneously clearing heat-toxin, rather than forcibly opening the pores with hot, pungent herbs as would be done for a Wind-Cold invasion. Wu Jutong called this an "acrid-cool balanced formula" (辛凉平剂).

King herbs

Jin Yin Hua (Honeysuckle) and Lian Qiao (Forsythia) are used in the heaviest dose. Both are aromatic, acrid, and cool. They simultaneously perform two critical tasks: dispersing Wind-Heat from the exterior, and clearing heat-toxin that warm pathogens tend to generate. Their aromatic quality also helps counteract the turbid, foul Qi that often accompanies epidemic diseases. The formula is named after these two herbs precisely because its focus is on treating the warm pathogen itself, not merely relieving surface symptoms.

Deputy herbs

Bo He (Mint) and Niu Bang Zi (Burdock Seed) are acrid and cool. They reinforce the King herbs by further dispersing Wind-Heat, clearing the head and eyes, and specifically benefiting the sore, swollen throat. Jing Jie Sui (Schizonepeta Spike) and Dan Dou Chi (Prepared Soybean) are slightly warm and acrid. Their inclusion is a hallmark of this formula's design: they powerfully open the pores and push the pathogen outward, yet they are mild enough that their warmth does not conflict with the overall cooling direction. The cool herbs keep their warming tendency in check, while their dispersing force amplifies the formula's ability to release the exterior.

Assistant herbs

Jie Geng (Platycodon) is a reinforcing assistant that opens and raises Lung Qi, helping to direct the formula upward to the Upper Burner where the pathogen resides. It also benefits the throat. Dan Zhu Ye (Bamboo Leaf) and Lu Gen (Reed Rhizome) are restraining assistants that clear residual Upper Burner heat, generate fluids, and counteract the fluid-depleting tendency of the dispersing herbs, thus protecting the body's Yin from damage by the warm pathogen.

Envoy herbs

Sheng Gan Cao (Raw Licorice) harmonises the entire formula and has its own mild heat-clearing and toxin-resolving actions. Paired with Jie Geng, it forms a classical two-herb combination specifically effective for sore throat.

Notable synergies

The Jin Yin Hua and Lian Qiao pairing is one of the most iconic in Chinese medicine: together they create a broad-spectrum heat-clearing and toxin-resolving effect that neither achieves alone. The Jing Jie and Jin Yin Hua combination exemplifies the principle that a small amount of warm-dispersing action, when embedded within a cool formula, enhances exterior release without generating internal heat. The Jie Geng and Gan Cao pair (from the classical Jie Geng Tang) directly treats sore throat by opening the Lung Qi and soothing inflammation.

How to Prepare

Traditional preparation instructions for Yin Qiao San

The original text instructs: pound all ingredients into a coarse powder. For each dose, take approximately 18g of the powder and decoct it in freshly prepared reed root (Lu Gen) decoction. Remove from heat as soon as the aromatic fragrance fully emerges. Do not over-boil, as Wu Jutong warned that Lung-directed medicines should be light and rising in nature, and over-cooking makes the flavour heavy, causing it to sink to the Middle Burner instead of acting on the Upper Burner.

For severe cases, take one dose every two hours (three doses during the day, one at night). For milder cases, take one dose every three hours (two during the day, one at night). If symptoms persist, continue dosing. Modern usage: prepare as a decoction using proportionally reduced dosages of the raw herbs. It may also be taken as a prepared pill or tablet.

Common Modifications

How practitioners adapt Yin Qiao San for specific situations

Added
Tian Hua Fen

12 - 15g, clears heat and generates fluids

When the warm pathogen has significantly damaged body fluids, causing pronounced thirst, Tian Hua Fen (Trichosanthes Root) is added for its strong fluid-generating and heat-clearing action to supplement Lu Gen and Dan Zhu Ye.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Yin Qiao San should not be used or requires extra caution

Avoid

Exterior Wind-Cold pattern (characterized by strong chills, absence of thirst, white tongue coat, and tight pulse). This formula is cooling and dispersing in nature and would worsen a cold-type condition.

Caution

Spleen Qi deficiency with loose stools or poor digestion. The cold and acrid nature of the formula may further weaken the digestive system.

Caution

Yin deficiency with pronounced interior Heat. Yin Qiao San is designed for exterior-level Heat, not deep-seated Yin-deficiency Heat. Use an appropriate Yin-nourishing formula instead.

Caution

Damp-Heat conditions. If significant Dampness is present alongside Heat, the formula requires modification (e.g., adding aromatic Dampness-transforming herbs) to be appropriate.

Caution

Prolonged use beyond the acute stage. Once fever has broken and the exterior pattern has resolved, the formula should be discontinued to avoid excessive cooling.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe for short-term use during pregnancy based on clinical precedent. A large population-based study in Taiwan found Yin Qiao San among the top herbal formulas prescribed to pregnant women, suggesting it is widely used in clinical practice without major safety concerns. None of the individual herbs in the standard composition (Jin Yin Hua, Lian Qiao, Jie Geng, Bo He, Zhu Ye, Gan Cao, Jing Jie Sui, Dan Dou Chi, Niu Bang Zi, Lu Gen) are classified as contraindicated during pregnancy in the Chinese Pharmacopoeia. However, as with all herbal formulas during pregnancy, it should only be taken under the guidance of a qualified practitioner. Bo He (Mint) in large doses has traditionally been cautioned in pregnancy due to its dispersing nature, but the amounts used in this formula are small and clinically acceptable. Gan Cao (Licorice) in prolonged high doses may affect fluid balance. The formula is designed for short-term acute use (a few days), which minimizes any theoretical risk.

Breastfeeding

Yin Qiao San is generally considered compatible with breastfeeding when used short-term for acute conditions. The formula's constituent herbs are mild and commonly used in postpartum clinical settings throughout East Asia without reported adverse effects on nursing infants. Gan Cao (Licorice) may theoretically affect fluid and electrolyte balance if used in large doses over prolonged periods, but the short-term use (3-5 days) typical for this formula makes this unlikely. Bo He (Mint) in very large quantities has historically been associated with reduced milk supply due to its dispersing nature, but the small amounts in this formula are not expected to have a meaningful effect. As a precaution, nursing mothers should take the formula only when genuinely needed for an acute Wind-Heat condition, keep the course as short as possible, and consult a qualified practitioner.

Children

Yin Qiao San has a long history of pediatric use and is one of the most commonly given formulas for children with Wind-Heat colds, febrile illnesses, and the early stages of measles or chickenpox. Dosage should be adjusted according to the child's age and weight. A common guideline is: - Infants under 1 year: generally not recommended without direct practitioner supervision - Ages 1-3: approximately one-quarter of the adult dose - Ages 3-6: approximately one-third of the adult dose - Ages 6-12: approximately one-half of the adult dose - Ages 12 and above: adult dose or near-adult dose Commercial preparations (granules, sachets) often include specific pediatric dosing instructions. The formula is mild and well tolerated, but as it is cool in nature, practitioners watch for signs of digestive upset in children with weaker constitutions. The classical instruction to take it frequently in small doses (rather than large infrequent doses) is especially applicable in children.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Yin Qiao San

Gan Cao (Licorice root) is the most pharmacologically active herb in this formula regarding drug interactions:

  • Licorice can cause sodium retention and potassium loss, potentially interacting with antihypertensives (reducing their effect), diuretics (especially thiazides and loop diuretics, compounding potassium loss), and cardiac glycosides such as digoxin (hypokalemia increases toxicity risk).
  • Licorice may interact with corticosteroids, potentiating their mineralocorticoid effects.
  • Glycyrrhizin in licorice can affect the metabolism of drugs processed through CYP3A4 pathways.

Bo He (Mint) contains menthol, which may theoretically affect the absorption of certain drugs when taken simultaneously. It is prudent to separate administration of this formula from pharmaceutical medications by at least 30-60 minutes.

General note: Because Yin Qiao San is typically used for only a few days during an acute illness, the clinical significance of these interactions is low for most patients. However, individuals on cardiac medications, blood pressure medications, or corticosteroids should inform their prescribing physician before taking this formula.

Usage Guidance

Practical advice for getting the most out of Yin Qiao San

Best time to take

Classically taken frequently in small doses throughout the day: every 2-3 hours for severe cases, every 3-4 hours for milder cases, including one dose at night. Best taken warm, between meals, on a relatively empty stomach.

Typical duration

Acute use: 1-5 days. Discontinue once fever breaks and exterior symptoms resolve.

Dietary advice

Avoid greasy, fried, and heavy foods, which obstruct the Lung Qi and impede the formula's light, dispersing action. Avoid spicy, hot foods (chili, ginger, lamb) that may add Heat to an already warm condition. Avoid cold, raw, or iced foods and drinks. Although the condition involves Heat, cold foods can trap the pathogen by constricting the surface and preventing it from being vented outward. Favor light, easily digestible foods such as congee (rice porridge), clear broths, lightly steamed vegetables, and pear. Drink warm water frequently to support the body's fluid recovery. Fresh reed root (Lu Gen) tea or chrysanthemum tea can complement the formula's actions.

Yin Qiao San originates from Wen Bing Tiao Bian (Systematic Differentiation of Warm Diseases) by Wu Jutong (吴鞠通) Qīng dynasty, 1798 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Yin Qiao San and its clinical use

Wu Jutong (吴鞠通), Wen Bing Tiao Bian (《温病条辨》), Upper Burner Chapter, Article 4:

「太阴风温、温热、温疫、冬温,初起恶风寒者,桂枝汤主之;但热不恶寒而渴者,辛凉平剂银翘散主之。」

"For Wind-Warmth of the Taiyin, Warm-Heat, Warm-Pestilence, and Winter-Warmth: if at onset there is aversion to wind and cold, Guizhi Tang governs. If there is only Heat without aversion to cold, and thirst is present, the acrid-cool balanced formula Yin Qiao San governs."

Wu Jutong, self-commentary on Yin Qiao San:

「本方谨遵《内经》'风淫于内,治以辛凉,佐以苦甘;热淫于内,治以咸寒,佐以甘苦'之训。」

"This formula carefully follows the Nei Jing's teaching: 'When Wind prevails internally, treat with acrid-cool, assisted by bitter and sweet; when Heat prevails internally, treat with salty-cold, assisted by sweet and bitter.'"

Wu Jutong, formula commentary:

「此方之妙,预护其虚,纯然清肃上焦,不犯中下,无开门揖盗之弊,有轻以去实之能。」

"The beauty of this formula is that it protectively guards against deficiency, purely clears and calms the Upper Burner, does not disturb the Middle or Lower, avoids the fault of 'opening the door and inviting the thief,' and achieves the ability to use lightness to resolve excess."

Wu Jutong, on preparation method:

「肺药取轻清,过煎则味厚而入中焦矣。」

"Lung medicines should capture what is light and pure; if over-decocted, the flavor becomes heavy and enters the Middle Burner instead."

Historical Context

How Yin Qiao San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Yin Qiao San was created by Wu Jutong (吴鞠通, 1758–1836), one of the most influential physicians of the Qing Dynasty Warm Disease (温病) school. It first appeared in his landmark work Wen Bing Tiao Bian (Systematic Differentiation of Warm Diseases), written around 1798 and first published in 1813. Wu Jutong described it as an "acrid-cool balanced formula" (辛凉平剂), placing it in the middle of a three-level hierarchy: Sang Ju Yin as the "light formula" for milder cases, Yin Qiao San as the "balanced formula" for moderate Wind-Heat, and Bai Hu Tang as the "heavy formula" for intense interior Heat.

Wu Jutong explicitly credited two sources for the formula's design. First, he followed the Huang Di Nei Jing's principle of treating Wind and Heat conditions with acrid-cool and bitter-sweet herbs. Second, he drew on Yu Jiayan's (喻嘉言) concept of using aromatic herbs to dispel turbid pestilential Qi. The formula was itself a modification of Li Dongyuan's (李东垣) Qingxin Liangge San (清心凉膈散), with the notable removal of Huang Qin (Scutellaria), which Wu considered too interior-penetrating for a surface-level illness. The addition of Jin Yin Hua, Jing Jie Sui, and Niu Bang Zi tailored the formula specifically for the defensive level of Warm Disease.

Wu Jutong's insistence on specific preparation methods became famous: the herbs should be lightly ground, briefly decocted in fresh reed root water, and taken as soon as the fragrance rises. He warned against prolonged cooking, which would make the formula too heavy and direct its effects to the Middle Burner instead of the Upper Burner where it was needed. This reflected his principle: "Treating the Upper Burner is like [lifting] a feather; only lightness can raise it" (治上焦如羽,非轻不举). In the modern era, Yin Qiao San has become one of the most widely used and commercially available Chinese herbal formulas worldwide, produced as tablets (银翘解毒片), pills, granules, and sachets.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Yin Qiao San

1

Maxingshigan-Yinqiaosan vs. Oseltamivir for H1N1 Influenza: A Randomized Controlled Trial (2011)

Wang C, Cao B, Liu QQ, et al. Annals of Internal Medicine, 2011, Vol. 155(4), pp. 217-225.

A prospective, randomized controlled trial across 11 hospitals in China enrolled 410 patients with lab-confirmed H1N1 influenza. Patients received oseltamivir, a combined Maxingshigan-Yinqiaosan decoction, both together, or no treatment. All three active groups significantly reduced time to fever resolution compared to controls (34%, 37%, and 47% reductions respectively). The combination reduced fever time by an additional 19% compared to oseltamivir alone. The herbal treatment was well tolerated with only two cases of mild nausea reported. Note: the herbal formula used was a combination of Maxing Shigan Tang and Yin Qiao San, not Yin Qiao San alone.

2

Eunkyosan (Yin Qiao San) and Samsoeum (Shen Su Yin) for the Common Cold: A Randomized, Placebo-Controlled, Multicenter Clinical Trial (2023)

Published on PubMed (PMID: 38033649), ClinicalTrials.gov: NCT04073511, 2023.

A multicenter, randomized, patient-assessor-blind, placebo-controlled trial evaluated Yin Qiao San (called Eunkyosan in Korean) and Shen Su Yin against placebo for the common cold. Adult participants with cold symptoms within 48 hours took the herbal formulas or placebo three times daily for up to 8 days. The primary outcome was the change in total WURSS-21-K symptom score on day 6. This trial is one of the first rigorous placebo-controlled studies specifically evaluating Yin Qiao San for the common cold.

PubMed
3

Pilot Study of Yin Qiao San in Children with Conventional Antipyretic Hypersensitivity (2015)

Published on PubMed (PMID: 26539405), 2015.

An open-label pilot study explored whether Yin Qiao San could safely provide fever relief in children aged 1-18 who were unable to use standard antipyretics (paracetamol and ibuprofen) due to hypersensitivity. Twenty-one children underwent oral provocation testing with Yin Qiao San and were then monitored during febrile episodes. The study assessed tolerability, time to fever resolution, and adverse events, suggesting feasibility of Yin Qiao San as an alternative antipyretic in this special population.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.