Mai Men Dong Tang

Ophiopogon Decoction · 麦门冬汤

Also known as: Mai Dong Tang (麦冬汤)

A classical formula for nourishing the lungs and stomach, used for persistent dry cough, throat dryness, shortness of breath, or nausea caused by depleted fluids in the respiratory and digestive systems. It works by replenishing moisture in the body while gently directing upward-rising Qi back downward.

Origin Jin Gui Yao Lue (金匮要略) by Zhang Zhongjing — Hàn dynasty, ~200 CE
Composition 6 herbs
Tian Men Dong
King
Tian Men Dong
Ban Xia
Deputy
Ban Xia
Ren Shen
Assistant
Ren Shen
Jing Mi
Assistant
Jing Mi
Da Zao
Assistant
Da Zao
Gan Cao
Envoy
Gan Cao
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Mai Men Dong Tang is designed to correct these specific patterns.

Why Mai Men Dong Tang addresses this pattern

When the Stomach's fluids are depleted, it can no longer send moisture upward to nourish the Lungs. The Lungs dry out, lose their natural descending function, and Qi rebels upward, producing cough, wheezing, and spitting of thin frothy sputum. The throat and mouth become parched because fluids cannot rise to moisten them. This formula addresses the root by heavily nourishing Lung and Stomach Yin with Mai Men Dong, while supporting the Stomach's fluid-generating capacity with Ren Shen, Jing Mi, Da Zao, and Gan Cao. Ban Xia descends the rebellious Qi that causes coughing and vomiting. The overall strategy restores the Lung-Stomach fluid axis from its source.

A practitioner would look for one or more of these signs

Chronic Coughing

Persistent dry cough or cough with thin frothy sputum

Dry Throat

Dry mouth and throat, especially worse at night

Shortness Of Breath

Shortness of breath, especially on exertion

Dry Mouth

Persistent thirst and dryness

Night Sweats

Warm palms and soles (five-palm heat)

Hoarseness

Hoarse or weak voice

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Mai Men Dong Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, chronic cough that persists after an illness or develops gradually is often attributed to depletion of the Lung's moisture. The Lung needs adequate fluids to perform its descending and dispersing functions. When Yin is depleted, the Lung dries out and its Qi rises upward instead of descending, producing a dry, persistent cough that may be accompanied by thin frothy sputum, a dry scratchy throat, and a weak or hoarse voice. Crucially, the Lung's fluids depend on the Stomach, because the digestive system is the primary source of all body fluids. So a chronic cough that arises from dryness often has its true root in weakened Stomach function.

Why Mai Men Dong Tang Helps

Mai Men Dong Tang attacks chronic cough from two directions. The heavy dose of Mai Men Dong (Ophiopogon root) directly moistens the dried Lung tissues and clears the low-grade heat that perpetuates the dryness. Simultaneously, Ren Shen, Jing Mi, Da Zao, and Gan Cao strengthen the Stomach's ability to produce fluids, addressing the root source. Ban Xia descends the rebellious Qi that drives the coughing reflex and helps transform any accumulated thin phlegm. Modern research supports this traditional use: a systematic review found that this formula reduced cough severity significantly compared to conventional antitussive medications, and experimental studies have confirmed anti-inflammatory and immunomodulatory effects relevant to airway hyperreactivity.

Also commonly used for

Chronic Bronchitis

When presenting with dry cough and Yin deficiency signs

Bronchiectasis

With Lung Yin deficiency presentation

Gastroesophageal Reflux Disease

With Yin-deficient nausea and dry throat

Vomit

When due to Stomach Yin deficiency

Pulmonary Tuberculosis

With Lung Yin deficiency pattern

Gastric Ulcer

With Stomach Yin deficiency presentation

Pertussis

Paroxysmal cough with thin sputum and throat dryness

What This Formula Does

Every TCM formula has a specific set of actions — here's what Mai Men Dong Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Mai Men Dong Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Mai Men Dong Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Mai Men Dong Tang works at the root level.

The condition this formula addresses begins in the Stomach, not the Lungs. In TCM, the Stomach is the body's primary source of fluids: it receives food and drink, extracts nourishment, and sends precious fluids upward to moisten the Lungs. When the Stomach's Yin (its cooling, moistening reserves) becomes depleted, whether through chronic illness, febrile disease that consumed fluids, or overwork, this upward supply of moisture dries up. The Lungs, which depend on the Stomach as a mother depends on Earth nurturing Metal (the "Earth generates Metal" or 培土生金 principle), are left parched.

Without adequate moisture, the Lungs cannot perform their normal descending and distributing function. Qi that should flow smoothly downward instead rebels upward, producing coughing, wheezing, and a sense of obstruction in the throat. The dryness also generates a paradoxical form of phlegm: because fluids are not being properly distributed, they congeal into sticky, turbid sputum or frothy saliva that is coughed up repeatedly. The more this sputum is expectorated, the more fluid is lost, creating a vicious cycle. Meanwhile, the Yin deficiency allows deficiency Heat (a low-grade smoldering warmth, not robust fever) to develop unchecked. This Heat further scorches the remaining fluids, producing dry mouth, dry throat, warm palms and soles, a red tongue with little coating, and a weak, rapid pulse. If the Stomach aspect predominates, nausea, hiccups, poor appetite, and vomiting may be the chief complaints instead.

The key insight of this formula is that treating the cough or the phlegm directly would miss the root cause. Instead, the strategy is to replenish the Stomach's fluid reserves so that moisture can once again rise naturally to nourish the Lungs, while simultaneously redirecting the rebellious Qi downward.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly sweet and mildly cool, with a slight acrid accent from the small dose of Ban Xia. The sweetness nourishes Yin, generates fluids, and tonifies the Middle Burner, while the subtle pungency prevents cloying stagnation and promotes Qi descent.

Channels Entered

Ingredients

6 herbs

The herbs that make up Mai Men Dong Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Tian Men Dong

Tian Men Dong

Asparagus tuber

Dosage 42 - 70g
Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Kidneys

Role in Mai Men Dong Tang

Used in a large dose as the principal herb, Mai Men Dong is sweet and cold. It nourishes Yin of both the Lung and Stomach, clears deficiency Heat, generates fluids, and moistens dryness. Its heavy dosage reflects the severity of Yin depletion that underlies this pattern.
Deputy — Assists and enhances the King
Ban Xia

Ban Xia

Pinellia rhizome

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs

Role in Mai Men Dong Tang

Though warm and drying by nature, Ban Xia is used in a deliberately small dose to descend rebellious Qi, resolve phlegm, and stop coughing. Paired with the large amount of Mai Men Dong, its drying properties are restrained while its descending action is preserved. This pairing exemplifies the classical principle of using opposites together for synergistic effect (相反相成).
Assistants — Supports or moderates other herbs
Ren Shen

Ren Shen

Ginseng root

Dosage 6 - 9g
Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys

Role in Mai Men Dong Tang

Tonifies Qi and generates fluids. Working with the Stomach-nourishing herbs, it strengthens the Spleen and Stomach's ability to produce and transport fluids upward to moisten the Lungs, embodying the 'nourishing Earth to generate Metal' (培土生金) strategy.
Jing Mi

Jing Mi

Non-glutinous rice

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Lungs

Role in Mai Men Dong Tang

Nourishes the Stomach, protects Stomach Qi, and assists in the production of fluids. Supports the strategy of strengthening the digestive system as the source of moisture for the Lungs.
Da Zao

Da Zao

Jujube fruit

Dosage 4 pieces (approximately 12g)
Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart

Role in Mai Men Dong Tang

Tonifies Qi, nourishes the Stomach, and generates fluids. Together with Ren Shen, Gan Cao, and Jing Mi, it supports the middle Qi so that the Stomach can produce adequate fluids to nourish the Lungs.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Mai Men Dong Tang

Moistens the Lungs, soothes the throat, tonifies the middle Qi, and harmonises all the herbs in the formula. Serves both as an assistant to support the Stomach and as an envoy to harmonise the prescription.

Why This Combination Works

How the herbs in Mai Men Dong Tang complement each other

Overall strategy

This formula addresses Lung and Stomach Yin deficiency with deficiency-Heat and rebellious Qi rising upward. The core logic follows the principle of 'nourishing Earth to generate Metal' (培土生金): by replenishing Stomach fluids and strengthening the Spleen, the formula restores the Lung's moisture from its source, while simultaneously directing upward-surging Qi back downward.

King herb

Mai Men Dong is used in an exceptionally large dose (42-70g), far outweighing all other ingredients combined. This dominance reflects the severity of the fluid deficit. Its sweet, cold nature directly nourishes the Yin of both the Lung and Stomach, clears deficiency-Heat, and generates fluids to moisten the dried respiratory tract. It addresses the root cause of the entire pattern.

Deputy herb

Ban Xia, though warm and drying, is the key strategic partner. Used in a deliberately small dose (about one-seventh of Mai Men Dong in the original text), it descends rebellious Qi, transforms accumulated phlegm, and opens the Stomach to promote fluid circulation. Its warming and drying nature is fully controlled by the massive amount of Mai Men Dong, while its Qi-descending function remains fully active. This pairing is one of the most celebrated examples in Chinese medicine of using opposites to enhance each other.

Assistant herbs

Ren Shen (reinforcing) tonifies Qi and generates fluids, strengthening the Spleen and Stomach as the source of all body fluids. Jing Mi and Da Zao (reinforcing) further nourish the Stomach and support fluid production. Together with Ren Shen, they ensure the digestive system can produce enough moisture to send upward to the Lungs.

Envoy herb

Gan Cao harmonises the formula, moderates the other herbs, and adds its own Lung-moistening and throat-soothing action. It guides the formula's effects to benefit the Lung and Stomach while protecting the middle Qi.

Notable synergies

The Mai Men Dong and Ban Xia pairing is the intellectual heart of the formula. Their 7:1 ratio in the original text ensures that moistening dominates while descending function is preserved. Mai Men Dong prevents Ban Xia from drying the fluids further, and Ban Xia prevents Mai Men Dong from being too cloying and generating stagnation. The four Stomach-supporting herbs (Ren Shen, Gan Cao, Jing Mi, Da Zao) together create a nourishing base that treats the root of the Lung's dryness by addressing the Stomach, its 'mother' organ in Five Phase theory.

How to Prepare

Traditional preparation instructions for Mai Men Dong Tang

Combine all six ingredients with approximately 2.4 litres (one dǒu two shēng) of water. Bring to a boil and simmer until the liquid is reduced to approximately 1.2 litres (six shēng). Strain and take warm, approximately 200 ml (one shēng) per dose, three times during the day and once at night.

In modern practice, use the standard dosages listed, decoct with water, and take in two divided doses per day. The rice (Jing Mi) should be cooked together with the herbs in the decoction, not added separately.

Common Modifications

How practitioners adapt Mai Men Dong Tang for specific situations

Added
Bei Sha Shen

9-15g, to enhance Yin-nourishing and fluid-generating effects

Yu Zhu

9-12g, to nourish Stomach Yin and moisten dryness

When fluid depletion is severe, adding Bei Sha Shen and Yu Zhu strengthens the formula's ability to generate fluids and nourish Yin without producing cloying stagnation.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Mai Men Dong Tang should not be used or requires extra caution

Avoid

Lung atrophy due to Deficiency Cold (虚寒肺痿). This formula is designed for Yin deficiency with Heat; using it in Cold-type Lung atrophy (characterized by thin white sputum, absence of thirst, frequent urination, and a pale tongue) would worsen the condition by introducing further cooling, moistening herbs where warming is needed.

Avoid

Dampness or Phlegm-Damp obstruction. The heavily moistening, Yin-nourishing nature of this formula (especially the large dose of Mai Men Dong) can trap existing Dampness and worsen phlegm accumulation in patients with a greasy tongue coating, heavy limbs, or copious watery sputum.

Caution

Cough or wheezing caused by external Wind-Cold invasion. When a pathogen is still lodged at the Exterior level, Yin-nourishing formulas can retain the pathogen inward rather than expelling it. The exterior condition should be resolved first before using this formula.

Caution

High fever with irritability from Excess Heat. This formula addresses deficiency Heat arising from depleted Yin, not robust Excess Heat patterns. Using it in cases of high fever with strong, forceful pulse and thick yellow tongue coating would be insufficient and could delay appropriate treatment.

Caution

Active Stomach bleeding or peptic ulcer with hemorrhage. Although the formula treats Stomach Yin deficiency, the Ren Shen (Ginseng) in the formula can potentially affect clotting dynamics. In acute hemorrhagic conditions, the underlying bleeding must be addressed first.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe with appropriate practitioner guidance. None of the six herbs in this formula are classified as abortifacient or strongly contraindicated in pregnancy. Ban Xia (Pinellia) has historically been listed as a pregnancy caution herb due to its acrid, drying nature, but in this formula it is used in very small proportion relative to the moistening Mai Men Dong, and Zhang Zhongjing himself used Ban Xia in pregnancy formulas (e.g. Gan Jiang Ren Shen Ban Xia Wan for morning sickness in the Jin Gui Yao Lue). The formula has in fact been used clinically for pregnancy-related nausea and vomiting due to Stomach Yin deficiency. Nevertheless, because Ban Xia is present, use should be supervised by a qualified practitioner, and the processed form (Zhi Ban Xia) should always be used rather than raw Ban Xia.

Breastfeeding

No specific safety concerns have been established for breastfeeding. The formula's ingredients are generally mild and nourishing. Gan Cao (Licorice) in sustained high doses can theoretically affect electrolyte balance, but the moderate dose in this formula is unlikely to cause problems. Mai Men Dong and Ren Shen are not known to have adverse effects on lactation or transfer harmful substances through breast milk. However, as with all herbal formulas during breastfeeding, use should be guided by a qualified practitioner and the minimum effective course should be used.

Children

Mai Men Dong Tang can be used in children, with appropriate dosage adjustments. General pediatric dosing follows age-based reductions: children under 3 years typically receive one-quarter to one-third of the adult dose, ages 3-7 receive one-third to one-half, and ages 7-14 receive one-half to two-thirds. Clinical case reports in the literature describe successful use in children (including a 14-year-old treated for post-meningitis sputum production). Because the formula is gentle and nourishing rather than harsh or purgative, it is generally well-tolerated in pediatric populations. The Ban Xia (Pinellia) component should always be in its processed form. For very young children, the decoction can be given in small, frequent doses rather than large single servings.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Mai Men Dong Tang

Gan Cao (Licorice root) is the most pharmacologically active herb in terms of drug interactions. Glycyrrhizin and glycyrrhetinic acid in Licorice can cause pseudoaldosteronism (sodium retention and potassium loss) with prolonged use. This creates potential interactions with:

  • Antihypertensives: Licorice may counteract blood pressure-lowering effects by promoting sodium and water retention.
  • Diuretics (especially potassium-wasting types like furosemide or thiazides): Combined potassium depletion can increase the risk of hypokalemia, which is dangerous for patients on cardiac glycosides.
  • Digoxin and cardiac glycosides: Licorice-induced hypokalemia can potentiate digoxin toxicity, increasing the risk of arrhythmias.
  • Corticosteroids: Licorice inhibits the enzyme 11-beta-hydroxysteroid dehydrogenase, potentially enhancing and prolonging corticosteroid effects.
  • Warfarin and anticoagulants: Some components of Licorice may have mild effects on coagulation pathways; monitoring is advised.

Ren Shen (Ginseng) may interact with:

  • Anticoagulants/antiplatelet agents: Ginsenosides have been reported to affect platelet aggregation. Close monitoring of INR is recommended if combined with Warfarin.
  • Hypoglycemic agents and insulin: Ginseng may have blood sugar-lowering effects, potentially enhancing the action of diabetes medications.
  • MAO inhibitors: Theoretical interaction due to Ginseng's stimulatory properties.

Patients taking any of these medications should inform their prescribing physician and herbalist to allow proper monitoring.

Usage Guidance

Practical advice for getting the most out of Mai Men Dong Tang

Best time to take

30 minutes after meals, 2-3 times daily. The original text specifies 'three times during the day and once at night' (日三夜一服), reflecting a frequent dosing strategy to maintain consistent nourishment of depleted fluids.

Typical duration

Typically prescribed for 1-4 weeks for acute dry cough or throat conditions; may be extended to 4-8 weeks for chronic conditions like Lung atrophy or chronic bronchitis, with regular reassessment by a practitioner.

Dietary advice

While taking this formula, favor foods that nourish Yin and moisten dryness: pears, white fungus (tremella/yin er), lily bulb (bai he), lotus seed, congee, honey, sesame, and tofu. Drink adequate warm fluids throughout the day. Avoid foods that are spicy, fried, greasy, or overly warming (such as chili peppers, lamb, ginger in excess, alcohol, and strong coffee), as these can further deplete Yin and generate Heat. Also minimize very cold or raw foods and iced drinks, which can impair the Stomach's digestive and fluid-generating function, undermining the formula's strategy of restoring Stomach Yin to nourish the Lungs.

Mai Men Dong Tang originates from Jin Gui Yao Lue (金匮要略) by Zhang Zhongjing Hàn dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Mai Men Dong Tang and its clinical use

Original indication from the Jin Gui Yao Lue (《金匮要略·肺痿肺痈咳嗽上气病脉证治第七》):

「火逆上气,咽喉不利,止逆下气者,麦门冬汤主之。」
"When fire causes counterflow Qi to rush upward and the throat is obstructed, to direct the counterflow downward and descend the Qi, Mai Men Dong Tang governs."

From the Jin Gui Yao Lue Xin Dian (《金匮要略心典》) by You Yi:

「火热挟饮致逆,为上气,为咽喉不利,与表寒挟饮上逆者悬殊矣。故以麦冬之寒治火逆,半夏之辛治饮气,人参、甘草之甘以补益中气。」
"Fire-Heat carrying fluid upward causes counterflow Qi rising and throat obstruction, entirely different from exterior Cold carrying fluid upward. Therefore, the coldness of Mai Dong treats fire counterflow, the acrid nature of Ban Xia treats the fluid aspect, and the sweetness of Ren Shen and Gan Cao supplements the Middle Qi."

From the Qian Jin Fang Yan Yi (《千金方衍义》):

「当知火逆上气,皆是胃中痰气不清,上溢肺隧,占据津液流行之道而然,是以倍用半夏,更用大枣通津涤饮为先,奥义全在乎此。」
"One should understand that fire causing Qi to surge upward is entirely due to impure phlegm-Qi in the Stomach overflowing into the Lung pathways and obstructing the channels of fluid circulation. This is why Ban Xia is used in relatively generous proportion, and Da Zao promotes fluid flow and clears accumulation. The profound meaning of the formula lies entirely here."

Historical Context

How Mai Men Dong Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Mai Men Dong Tang originates from Zhang Zhongjing's Jin Gui Yao Lue (Synopsis of the Golden Chamber), composed during the late Eastern Han Dynasty (circa 200 CE). It appears in the chapter on Lung atrophy, Lung abscess, cough, and counterflow Qi (肺痿肺痈咳嗽上气病脉证治), where it is the principal formula for the Yin-deficiency Heat type of Lung atrophy (虚热肺痿).

The formula is widely praised in later commentaries for the brilliance of including Ban Xia among strongly moistening herbs. The Qing dynasty physician Yu Chang (喻昌) famously remarked in the Yi Men Fa Lu (医门法律) that Lung atrophy fundamentally arises because "the Stomach's fluids fail to reach the Lungs, leaving them without nourishment, becoming ever more parched and dry." The Yi Zong Jin Jian (医宗金鉴) commentary, citing Zhou Yangzun, celebrated Zhongjing's inclusion of Ban Xia as an innovation "surpassing all ages" (擅古今未有之奇), recognizing that the small dose of this acrid, warm herb among sweet, cool ingredients creates a complementary tension that prevents the moistening herbs from becoming cloying while preserving Ban Xia's ability to descend Qi and clear phlegm.

The formula also had significant influence in Japanese Kampo medicine. The Edo-period physician Otai Yodo (尾台榕堂, 1799-1870) discussed it in the Ruiju Ho Kogi (类聚方广义), noting its use for chronic cough, wheezing, shortness of breath, and nausea. Later, Ye Tianshi (叶天士) in the Qing dynasty developed his famous Sha Shen Mai Men Dong Tang (沙参麦冬汤) as a derivative, adapting the original concept for Warm Disease (温病) treatment of Lung and Stomach dryness, though without Ban Xia's descending action.

Modern Research

5 published studies investigating the pharmacological effects or clinical outcomes of Mai Men Dong Tang

1

A Chinese classical prescription Maimendong decoction in treatment of pulmonary fibrosis: an overview (Narrative Review, 2024)

Lao Q, Wang X, Zhu G, Yuan H, Ma T, Wang N. Frontiers in Pharmacology, 2024, Vol. 15, 1329743.

This comprehensive review examined the clinical and experimental evidence for Maimendong Decoction in treating pulmonary fibrosis. It found that the formula and its individual herbal components demonstrate anti-fibrotic effects through multiple mechanisms: reducing inflammatory cytokines, inhibiting pro-fibrotic factors and oxidative stress, promoting bone marrow mesenchymal stem cell differentiation and homing, and enhancing cellular autophagy. The authors noted that MMDD has been used clinically for pulmonary fibrosis treatment in China, Japan, and South Korea, though high-quality randomized controlled trials remain limited.

DOI
2

Modified Maimendong decoction in the treatment of patients with idiopathic pulmonary fibrosis: Study protocol for a randomized controlled trial (RCT Protocol, 2020)

Medicine, 2020, Vol. 99, Issue 49, e23440.

This study published a protocol for a double-blind, placebo-controlled RCT evaluating Modified Maimendong Decoction combined with Pirfenidone versus placebo plus Pirfenidone in 60 patients with idiopathic pulmonary fibrosis showing Qi and Yin deficiency syndrome. The trial was designed to measure lung function (FVC, FEV1, DLCO), quality of life (SGRQ scores), and safety outcomes over a defined treatment period.

PubMed
3

Maimendong decoction regulates M2 macrophage polarization to suppress pulmonary fibrosis via PI3K/Akt/FOXO3a signalling pathway (Preclinical, 2023)

Shuangshuang H, Mengmeng S, Lan Z, Fang Z, Yu L. Journal of Ethnopharmacology, 2024, Vol. 319, 117308.

Using a bleomycin-induced pulmonary fibrosis rat model, this study found that Maimendong Decoction inhibited M2 macrophage polarization and the release of pro-fibrotic factors. The mechanism involved suppression of the PI3K/Akt/FOXO3a signaling pathway, leading to reduced fibroblast activation. The authors concluded the formula shows promise as an anti-fibrotic treatment, though clinical validation is still needed.

PubMed
4

Maimendong decoction modulates the PINK1/Parkin signaling pathway, alleviates type 2 alveolar epithelial cell senescence and enhances mitochondrial autophagy (Preclinical, 2025)

Journal of Ethnopharmacology, 2025.

This animal study investigated whether Maimendong Decoction alleviates idiopathic pulmonary fibrosis by reducing cellular senescence in type 2 alveolar epithelial cells and enhancing mitochondrial autophagy via the PINK1/Parkin pathway. Using a bleomycin-induced mouse model, the formula was administered for 7 or 28 days and compared with Pirfenidone. Results showed improvement in lung pathology and body weight metrics.

PubMed
5

Maimendong decoction suppresses non-small cell lung cancer growth by promoting dendritic cell maturation via the SIRT1/p65 acetylation pathway (Preclinical, 2026)

Zhou Q, Song Y, Guo Y, et al. iScience, 2026, Vol. 29(2), 114774.

Using a Lewis lung carcinoma mouse model, researchers found that Maimendong Decoction suppressed tumor growth, enhanced CD8+ T cell infiltration, and promoted dendritic cell maturation. The immunological mechanism was linked to the SIRT1/p65 acetylation pathway. While this is an early-stage preclinical study, it suggests potential immunomodulatory properties relevant to lung cancer research.

DOI

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.