Sha Shen Mai Men Dong Tang

Glehnia and Ophiopogon Decoction · 沙參麥門冬湯

Also known as: Sha Shen Mai Dong Tang, Adenophora and Ophiopogon Combination

A gentle, cooling formula used to restore moisture and fluids to the Lungs and Stomach when they have become dried out. It is commonly used for persistent dry cough, dry throat, thirst, and other symptoms of dryness, particularly during autumn or following a feverish illness. The formula nourishes without being heavy, making it well-suited for conditions where the body's natural moistening fluids have been depleted.

Origin Wen Bing Tiao Bian (温病条辨, Systematic Differentiation of Warm Diseases) by Wu Jutong (吴鞠通) — Qīng dynasty, 1798 CE
Composition 7 herbs
Bei Sha Shen
King
Bei Sha Shen
Mai Dong
King
Mai Dong
Yu zhu
Deputy
Yu zhu
Tian Hua Fen
Deputy
Tian Hua Fen
Sang Ye
Assistant
Sang Ye
Bai Bian Dou
Assistant
Bai Bian Dou
Gan Cao
Envoy
Gan Cao
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Sha Shen Mai Men Dong Tang is designed to correct these specific patterns.

Why Sha Shen Mai Men Dong Tang addresses this pattern

This is the primary pattern addressed by the formula. When dryness (whether from autumn climate, lingering warm-disease, or chronic depletion) damages the Yin fluids of the Lungs and Stomach, the body loses its ability to moisten the respiratory tract and digestive system. The Lungs, which prefer moisture and are easily injured by dryness, develop dry cough and a parched throat. The Stomach, deprived of its lubricating fluids, fails to properly receive food and transport nutrients, causing thirst and poor appetite. Bei Sha Shen and Mai Men Dong directly nourish the Yin of both organs, while Yu Zhu and Tian Hua Fen generate fresh fluids. Sang Ye gently clears residual dryness-heat from the Lung surface, and Sheng Bian Dou protects the Spleen from being overwhelmed by the moistening herbs. The overall effect is a gentle, thorough restoration of fluid balance in the upper and middle parts of the body.

A practitioner would look for one or more of these signs

Dry Cough

Dry cough with little or no phlegm, or phlegm that is scanty and sticky

Dry Throat

Dry, parched throat and mouth

Thirst

Persistent thirst with desire to drink

Low Grade Fever

Low-grade fever or mild heat sensation, especially in the afternoon

Hoarseness

Hoarse or weakened voice

Dark Skin

Dry skin or dry nose

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Sha Shen Mai Men Dong Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, the throat is governed by the Lung and Stomach channels. When the Yin fluids of these two organs become depleted (whether from prolonged illness, overuse of the voice, dry climate, or lingering heat), the throat loses its natural lubrication. Without sufficient moisture, the throat becomes dry, hot, and irritated. This creates a self-perpetuating cycle: dryness generates deficiency-heat, which further burns up fluids, causing more dryness. The condition tends to worsen in autumn and winter when environmental dryness compounds the internal deficiency.

Why Sha Shen Mai Men Dong Tang Helps

Sha Shen Mai Men Dong Tang restores the moisture supply to the throat from its source. Bei Sha Shen and Mai Men Dong nourish the Lung and Stomach Yin that feeds the throat tissues, while Tian Hua Fen and Yu Zhu generate fresh fluids to directly relieve dryness. Sang Ye gently clears residual heat from the Lung channel that passes through the throat. Clinical studies have reported a total effective rate exceeding 95% when this formula was used for chronic pharyngitis with Yin deficiency presentation, significantly outperforming conventional treatments.

Also commonly used for

Pulmonary Tuberculosis

When presenting with dry cough and Yin deficiency signs

Chronic Hemorrhagic Gastritis

With Stomach Yin deficiency pattern

Constipation

Dryness-type constipation due to fluid depletion in the intestines

Diabetes

Upper and middle wasting-thirst (xiao ke) with Yin deficiency

Pneumonia

Late-stage or recovery phase with residual dry cough and Yin damage

Mouth Ulcers

Recurrent oral ulcers due to Stomach Yin deficiency with virtual fire

Dry Cough

Persistent dry cough from any cause where Lung Yin depletion is identified

What This Formula Does

Every TCM formula has a specific set of actions — here's what Sha Shen Mai Men Dong Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Sha Shen Mai Men Dong Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Sha Shen Mai Men Dong Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Sha Shen Mai Men Dong Tang works at the root level.

This formula addresses a situation in which the Lungs and Stomach have been depleted of their vital moisture. In TCM, the Lungs are called the "tender organ" (娇脏) because they are particularly vulnerable to external drying forces. The Stomach similarly depends on a steady supply of fluids to carry out its digestive functions. When a warm-dryness pathogen (温燥) invades during autumn, or when lingering Heat from a febrile illness has consumed the body's Yin fluids, both organs are left parched.

Without adequate moisture, the Lungs cannot perform their normal function of dispersing and descending Qi. This causes Lung Qi to rebel upward, producing a dry, hacking cough with little or no phlegm. The throat and nose become dry and irritated. When the Stomach is also affected, its fluids are depleted, leading to thirst, a dry mouth, and poor appetite. The tongue typically appears red with little coating or a bare, shiny surface, reflecting the loss of nourishing fluids.

The key insight of Wu Jutong's approach is that this condition sits at a specific severity level: the external pathogen has largely been dealt with, but the damage it caused to the body's fluids remains. It is deeper than a simple Wind-Dryness invasion (which would be treated with Sang Xing Tang) but less severe than extreme fluid depletion with intense residual Heat (treated with Qing Zao Jiu Fei Tang). The formula's gentle, sweet, and cool nature is perfectly calibrated for this middle ground, restoring lost fluids without being too heavy or stagnating.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly sweet with mild bitter undertones. The sweet taste nourishes Yin and generates fluids, while the slight bitterness gently clears residual Heat without drying.

Target Organs

Channels Entered

Ingredients

7 herbs

The herbs that make up Sha Shen Mai Men Dong Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Bei Sha Shen

Bei Sha Shen

Glehnia root

Dosage 9 - 15g
Temperature Slightly Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Stomach

Role in Sha Shen Mai Men Dong Tang

Clears and nourishes Lung Yin, generates fluids, and moistens dryness. As one of the two King herbs, it directly addresses the core pathomechanism of Lung and Stomach Yin depletion caused by dryness.
Mai Dong

Mai Dong

Ophiopogon root

Dosage 9 - 15g
Temperature Slightly Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, Stomach

Role in Sha Shen Mai Men Dong Tang

Nourishes Yin and moistens the Lungs, clears Heat from the Heart and Stomach, and generates fluids. Paired with Bei Sha Shen, it forms the core nourishing axis of the formula, targeting both Lung and Stomach Yin deficiency.
Deputies — Assists and enhances the King
Yu zhu

Yu zhu

Solomon's seal rhizome

Dosage 6 - 10g
Temperature Slightly Cool
Taste Sweet (甘 gān)
Organ Affinity Lungs, Stomach

Role in Sha Shen Mai Men Dong Tang

Nourishes Yin and moistens dryness without being cloying or stagnating. It reinforces the King herbs by generating fluids in the Stomach and Lung, helping to restore depleted body fluids.
Tian Hua Fen

Tian Hua Fen

Trichosanthes root

Dosage 4.5 - 10g
Temperature Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Stomach

Role in Sha Shen Mai Men Dong Tang

Clears Heat, generates fluids, and relieves thirst. It supplements the King herbs by directly addressing the dry-heat component of the pathomechanism and strongly promotes fluid production.
Assistants — Supports or moderates other herbs
Sang Ye

Sang Ye

Mulberry leaf

Dosage 4.5 - 10g
Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Liver

Role in Sha Shen Mai Men Dong Tang

Gently clears and disperses dryness-heat from the Lungs without being harsh or overly drying. It helps to vent residual pathogenic factors from the Lung system and supports cough relief.
Bai Bian Dou

Bai Bian Dou

White hyacinth bean

Dosage 4.5 - 10g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach

Role in Sha Shen Mai Men Dong Tang

Strengthens the Spleen and supports its transformation and transportation function. When Stomach Yin is depleted, Spleen function is inevitably affected. This herb protects the middle and ensures the rich Yin-nourishing herbs do not cause stagnation.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Sha Shen Mai Men Dong Tang

Clears Heat, harmonizes the Middle Burner, generates fluids to relieve thirst, and harmonizes all other herbs in the formula.

Why This Combination Works

How the herbs in Sha Shen Mai Men Dong Tang complement each other

Overall strategy

When autumn dryness or lingering warmth damages the Yin fluids of the Lungs and Stomach, the treatment principle is to use sweet, cool substances to gently restore moisture and nourish the depleted fluids. Wu Jutong described this approach as using "sweet-cold methods to rescue the body's fluids" (甘寒救其津液), a strategy that avoids bitter-cold herbs which would further dry out the body.

King herbs

Bei Sha Shen and Mai Men Dong serve as the paired King herbs, both used at the highest dosage in the formula (three qian each in the original text). Bei Sha Shen enters the Lung and Stomach channels, directly nourishing the Yin of both organs. Mai Men Dong complements this by moistening the Lung and clearing deficiency-heat. Together they form the core "sweet-cold nourishing" action that addresses the root cause of Lung-Stomach Yin depletion.

Deputy herbs

Yu Zhu and Tian Hua Fen reinforce the King herbs from complementary angles. Yu Zhu is prized for nourishing Yin and generating fluids without being cloying or heavy, making it ideal for a formula that needs to moisten without creating stagnation. Tian Hua Fen adds a stronger fluid-generating and thirst-relieving action while gently clearing residual dryness-heat.

Assistant herbs

Sang Ye (mulberry leaf, specifically the winter-harvested variety) serves as a reinforcing assistant that lightly clears and disperses dryness-heat from the Lung. It provides the formula with a gentle outward-moving action to address any residual pathogenic dryness still lodged in the upper body, preventing the formula from being purely supplementing. Sheng Bian Dou (raw hyacinth bean) acts as a restraining assistant, strengthening Spleen Qi and supporting the Middle Burner's digestive function. Since a damaged Stomach inevitably compromises the Spleen's ability to transport and transform, this herb ensures that the rich Yin-nourishing herbs can be properly absorbed without causing dampness or stagnation.

Envoy herbs

Sheng Gan Cao (raw licorice) harmonizes all the other ingredients while contributing its own mild Heat-clearing and fluid-generating actions. It directs the formula's benefits toward the Middle Burner and ensures smooth coordination among the formula's components.

Notable synergies

The pairing of Bei Sha Shen and Mai Men Dong is the signature combination: both nourish Lung and Stomach Yin, but Sha Shen has a lighter, more Qi-oriented nourishing quality while Mai Men Dong is richer and more moistening, creating a balanced restoration of both Qi and Yin aspects. The combination of Sang Ye with the Yin-nourishing body of the formula is also notable: Sang Ye provides a subtle outward-dispersing quality that prevents the formula from simply supplementing inward, ensuring that any remaining pathogenic dryness is gently expelled rather than trapped.

How to Prepare

Traditional preparation instructions for Sha Shen Mai Men Dong Tang

Place the herbs in a pot with approximately 1000 ml (five cups) of water. Bring to a boil, then reduce to a gentle simmer and cook until the liquid is reduced to approximately 400 ml (two cups). Strain and divide into two portions. Take one portion in the morning and one in the evening, on the same day. Prepare a fresh decoction daily.

Common Modifications

How practitioners adapt Sha Shen Mai Men Dong Tang for specific situations

Added
Di Gu Pi

9g, clears deficiency-heat from the Lung to address lingering low-grade fever

This is the original modification specified in the source text. When dryness-heat lingers in the Lung and causes persistent fever or cough, Di Gu Pi's bitter-cold nature helps clear the deeper heat that sweet-cold herbs alone cannot resolve.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Sha Shen Mai Men Dong Tang should not be used or requires extra caution

Avoid

Wind-Cold or exterior patterns that have not yet resolved. Using moistening, Yin-nourishing herbs in the presence of an unresolved external pathogen can trap the pathogen inside the body (a principle known as 'closing the door on the thief').

Avoid

Phlegm-Dampness obstruction or profuse, watery sputum. The rich, moistening nature of this formula can worsen Dampness and increase phlegm production in people who already have heavy, turbid phlegm or a thick, greasy tongue coating.

Caution

Spleen and Stomach deficiency Cold with loose stools or diarrhea. Most herbs in this formula are cool or cold in nature, and they are cloying (rich and sticky), which can further impair a weak, cold digestive system.

Caution

Severe, high-grade Heat patterns actively consuming fluids (such as Qi-level blazing Heat). This formula is gentle and nourishing, designed for the aftermath of Heat damage rather than for combating vigorous active Heat. Stronger Heat-clearing formulas are more appropriate in those situations.

Caution

Poor appetite, bloating, or food stagnation. The Yin-nourishing herbs in the formula may aggravate feelings of fullness and impede digestion.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe in pregnancy based on its composition of mild, nourishing herbs. The formula contains no known abortifacient, blood-moving, or strongly descending herbs. Tian Hua Fen (Trichosanthes root) warrants attention because related Trichosanthes preparations (particularly trichosanthin protein) have documented abortifacient properties. However, the root as used in standard decoction dosages is not the same as concentrated trichosanthin and has traditionally been used without specific pregnancy prohibitions in this context. Some commercial formulations list pregnancy as a contraindication out of caution. Pregnant individuals should consult a qualified practitioner before use.

Breastfeeding

No specific safety concerns have been identified for breastfeeding. The formula consists of mild, nourishing herbs that do not contain known toxic compounds likely to transfer into breast milk in harmful concentrations. The cool nature of the formula is theoretically appropriate for a nursing parent experiencing Yin deficiency with dryness symptoms. However, the formula's cool and moistening character could potentially affect milk quality in individuals with underlying Spleen-Stomach weakness. A qualified practitioner should be consulted for individual guidance.

Children

This formula is suitable for pediatric use and has been widely applied in children's clinical practice, particularly for chronic cough with Yin deficiency and mycoplasma pneumonia during recovery. Dosages should be reduced according to age: roughly one-third of the adult dose for children under 6, and one-half to two-thirds for children aged 6 to 12. The sweet taste profile makes it relatively palatable for children. Because children's digestive systems are more delicate, practitioners should monitor for any signs of loose stools or appetite reduction, which may indicate the formula's cool, moistening nature is too heavy for the child's Spleen function. Adding a small amount of a Spleen-supporting herb may be appropriate in such cases.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Sha Shen Mai Men Dong Tang

Gan Cao (Licorice root) in this formula may interact with several classes of medications. Glycyrrhizin in licorice can cause potassium loss and sodium retention, potentially interacting with diuretics (especially thiazides and loop diuretics), cardiac glycosides (such as digoxin, where hypokalemia increases toxicity risk), corticosteroids (additive potassium-depleting effects), and antihypertensive medications (by promoting fluid retention that counteracts their effect).

Tian Hua Fen (Trichosanthes root) has blood-sugar-lowering properties and may potentiate the effects of hypoglycemic agents (including insulin and oral antidiabetics), warranting closer blood glucose monitoring.

The formula's overall fluid-nourishing and moistening properties may theoretically influence the absorption of concurrently taken oral medications. As a general precaution, it is advisable to separate the formula from pharmaceutical drugs by at least one to two hours.

Usage Guidance

Practical advice for getting the most out of Sha Shen Mai Men Dong Tang

Best time to take

30 minutes before meals or 1 hour after meals, twice daily (morning and evening), for optimal absorption of Yin-nourishing herbs.

Typical duration

Typically taken for 1 to 4 weeks for acute dryness conditions; may be used for several weeks to months for chronic Yin deficiency, with periodic reassessment by a practitioner.

Dietary advice

Favor foods that moisten and nourish: pears, white fungus (yin er/tremella), lily bulb (bai he), congee, honey, tofu, and sesame. Drink plenty of warm fluids. Avoid spicy, pungent, greasy, and fried foods, which generate Heat and further consume fluids. Limit alcohol, coffee, and strong tea, as these are drying. Raw and cold foods should be consumed in moderation to protect Stomach function. Dry roasted nuts and heavily salted snacks should also be minimized as they contribute to internal dryness.

Sha Shen Mai Men Dong Tang originates from Wen Bing Tiao Bian (温病条辨, Systematic Differentiation of Warm Diseases) by Wu Jutong (吴鞠通) Qīng dynasty, 1798 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Sha Shen Mai Men Dong Tang and its clinical use

Wu Jutong (吴鞠通), Wen Bing Tiao Bian (《温病条辨》), Upper Burner Chapter, Autumn Dryness section:

燥伤肺胃阴分,或热或咳者,沙参麦冬汤主之。

"When Dryness injures the Yin of the Lungs and Stomach, with either Heat or cough, Sha Shen Mai Men Dong Tang governs."

Wu Jutong classified this formula under the sweet and cold method (甘寒法, gān hán fǎ), specifying it as a gentle approach to replenishing damaged fluids rather than aggressively clearing Heat. He noted that the formula's dosages of Sha Shen and Mai Dong are larger than those in Sang Xing Tang, indicating that this formula targets a deeper level of Yin injury than the lighter Sang Xing Tang, but addresses less severe Heat than Qing Zao Jiu Fei Tang. Wu described the overall strategy as "using the sweet and cold method to rescue the body's fluids" (甘寒救其津液).

Historical Context

How Sha Shen Mai Men Dong Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Sha Shen Mai Men Dong Tang was created by Wu Jutong (吴鞠通, 1758–1836), one of the four great masters of the Warm Disease (温病) school, and published in his landmark work Wen Bing Tiao Bian (Systematic Differentiation of Warm Diseases) in 1798. Wu designed this formula as part of his systematic approach to autumn dryness conditions, organizing treatment into graduated levels of severity. He considered it a representative example of the "sweet and cold method" (甘寒法) for rescuing depleted fluids.

The formula is closely related to other formulas in Wu's system. Removing Sang Ye, Bian Dou, and Tian Hua Fen produces Yu Zhu Mai Men Dong Tang, which treats dryness focused more on the Stomach. The formula also shares key herbs with the older Mai Men Dong Tang from Zhang Zhongjing's Jin Gui Yao Lue, though the two formulas differ significantly in strategy: Mai Men Dong Tang uses a large dose of Mai Dong with Ban Xia to simultaneously nourish Yin and redirect rebellious Qi, while Sha Shen Mai Men Dong Tang is lighter and more purely moistening. The famous modern physician Shi Jinmo (施今墨) praised this formula's elegant simplicity, noting that it achieves "clearing without being too cold, moistening without being stagnating" (清不过寒,润不呆滞), making it one of the most widely used Yin-nourishing formulas in modern clinical practice.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Sha Shen Mai Men Dong Tang

1

Systematic Review and Meta-Analysis: Clinical Efficacy and Safety of Shashen Maidong Decoction in the Treatment of Pediatric Mycoplasma Pneumonia (2021)

Wang J, Ma X, Wei S, Yang T, Tong Y, Jing M, Wen J, Zhao Y. Frontiers in Pharmacology, 2021, 12:765656.

This systematic review pooled data from multiple randomized controlled trials evaluating Shashen Maidong Decoction for childhood mycoplasma pneumonia. The analysis found that the formula significantly improved clinical outcomes, reduced cough duration, and shortened fever resolution time when combined with standard antibiotic therapy. However, the authors cautioned that study quality was generally low and larger, more rigorous trials are needed.

2

Clinical Trial: Changes in Urinary Cu, Zn, and Se Levels in Cancer Patients After Treatment with Sha Shen Mai Men Dong Tang (2015)

Journal of Traditional and Complementary Medicine, 2016, 6(2):135-139.

This clinical trial treated 42 head and neck cancer patients and 10 lung cancer patients with the formula during chemoradiotherapy. Treatment was associated with significant changes in urinary trace element levels: decreased copper and increased zinc and selenium, suggesting the formula may help modulate mineral status disrupted by cancer treatment. These trace element shifts are considered potentially favorable for antioxidant status.

3

Preclinical Study: Shashen-Maidong Decoction-Mediated IFN-γ and IL-4 on the Regulation of Th1/Th2 Imbalance in Radiation Pneumonitis Rats (2019)

Yang Y, Zhou Y. BioMed Research International, 2019, 2019:6012473.

This animal study investigated how the formula affects immune balance in rats with radiation-induced lung inflammation. The decoction improved immune function by increasing IFN-γ and decreasing IL-4 concentrations, helping to correct the Th1/Th2 immune imbalance characteristic of radiation pneumonitis. Results suggest a possible immunomodulatory mechanism for the formula's traditional use in treating lung dryness and inflammation.

4

Network Pharmacology Study: Deciphering Potential Pharmacological Mechanism of Sha-Shen-Mai-Dong Decoction on Primary Sjögren's Syndrome (2021)

Jiang Y, Zhao X, Yu J, Wang Q, Wen C, Huang L. BMC Complementary Medicine and Therapies, 2021, 21(1):79.

Using network pharmacology and molecular docking approaches, this study identified potential molecular targets and pathways through which the formula may benefit primary Sjögren's syndrome, a condition characterized by severe dryness of the eyes and mouth. The analysis revealed multiple active components targeting inflammation-related and immune-regulatory pathways, providing a modern scientific basis for the formula's traditional indication of treating dryness syndromes.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.