Xiao Feng San

Wind-Eliminating Powder · 消風散

Also known as: Eliminate Wind Powder, Wind-Dispersing Powder, Tangkuei and Arctium Formula,

A classical formula for itchy, red skin rashes that may ooze fluid after scratching, such as eczema, hives, and allergic dermatitis. It works by dispersing Wind from the skin surface, clearing Heat, draining Dampness, and nourishing the Blood to address both the symptoms and the underlying causes of these skin eruptions.

Origin Wài Kē Zhèng Zōng (外科正宗, Orthodox Lineage of External Medicine) by Chén Shí Gōng (陈实功) — Míng dynasty, 1617 CE
Composition 13 herbs
Jing Jie
King
Jing Jie
Fang Feng
King
Fang Feng
Niu Bang Zi
King
Niu Bang Zi
Chan Tui
King
Chan Tui
Cang Zhu
Deputy
Cang Zhu
Ku Shen
Deputy
Ku Shen
Mu Tong
Deputy
Mu Tong
Shi Gao
Deputy
Shi Gao
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Xiao Feng San is designed to correct these specific patterns.

Why Xiao Feng San addresses this pattern

When Wind and Heat invade the skin together, they become trapped in the pores and interstices, unable to dissipate outward or be resolved inward. The Heat inflames the skin, causing redness and a burning sensation, while the Wind triggers restless itching that shifts from place to place. The formula's four King herbs (Jing Jie, Fang Feng, Niu Bang Zi, Chan Tui) open the interstices to vent the Wind outward, while Shi Gao and Zhi Mu clear the Heat component. Sheng Di Huang cools any Heat that has entered the Blood level, preventing deeper progression.

A practitioner would look for one or more of these signs

Itchy Skin

Intense, shifting itching that worsens with warmth

Skin Rashes

Red rashes or hives appearing suddenly across the body

Skin Dryness

Bright red coloration of skin lesions

Restlessness

Irritability and restlessness from persistent itching

Thirst

Thirst and dry mouth indicating interior Heat

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Xiao Feng San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Wind-Damp Blood-Heat with Wind

TCM Interpretation

In TCM, eczema is understood as arising when Wind, Dampness, and Heat combine and lodge in the skin. There is often a pre-existing internal tendency toward Damp-Heat (perhaps from dietary habits or constitutional factors) that creates vulnerability. When external Wind invades, it becomes trapped in the space between skin and muscle, unable to be vented outward or resolved inward. The trapped Wind causes itching, the Dampness causes weeping and oozing, and the Heat causes redness and inflammation. Over time, the condition can damage the Blood and Yin, leading to dry, thickened skin in chronic cases. The Spleen and Lung organ systems are typically involved: the Spleen governs moisture metabolism (Dampness tends to accumulate when the Spleen is weak), while the Lung governs the skin and the body's defensive boundary.

Why Xiao Feng San Helps

Xiao Feng San attacks the three pathogenic factors driving eczema simultaneously. Its four King herbs (Jing Jie, Fang Feng, Niu Bang Zi, Chan Tui) open the pores to vent Wind outward, directly relieving the itching. Cang Zhu, Ku Shen, and Mu Tong dry and drain the Dampness responsible for oozing and weeping. Shi Gao and Zhi Mu clear the Heat that causes redness and burning. Crucially, Dang Gui, Sheng Di Huang, and Hei Zhi Ma nourish the Blood and Yin to prevent the formula's drying herbs from worsening skin dryness. A randomized, double-blind, placebo-controlled trial found that Xiao Feng San significantly reduced lesion scores, itching, and sleep disruption in patients with refractory atopic dermatitis compared to placebo.

Also commonly used for

Allergic Dermatitis

Contact dermatitis and allergic skin reactions

Drug Eruption

Drug-induced dermatitis or skin eruptions

Psoriasis

Psoriasis with red, itchy plaques in the acute inflammatory stage

Neurodermatitis

Neurodermatitis (神经性皮炎) with chronic itching

Scabies

Scabies (疥疮) as mentioned in the original source text

Herpes Zoster Infection

Shingles (带状疱疹) with red, painful vesicles

What This Formula Does

Every TCM formula has a specific set of actions — here's what Xiao Feng San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Xiao Feng San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Xiao Feng San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Xiao Feng San works at the root level.

Xiao Feng San addresses a condition where external pathogenic factors (Wind, Dampness, and Heat) invade the body and become trapped between the skin and flesh, unable to vent outward or drain inward. The underlying disease logic involves several interacting layers.

First, Wind is the primary pathogen driving the itching. In TCM, Wind is characterized by rapid movement and change, which explains why the rashes and itching appear suddenly, shift location, and come and go unpredictably. When Wind invades the exterior, it lodges in the interstices (the spaces between skin and muscle) and disrupts the normal flow of Qi and Blood through the skin. Second, Dampness combines with Wind, causing the characteristic weeping and oozing of fluid when lesions are scratched. Dampness is heavy, sticky, and lingering, which is why these skin conditions tend to be stubborn and slow to resolve. Third, Heat contributes redness, inflammation, and a burning quality to the lesions. Heat may arrive from outside along with Wind, or it may be generated internally when Wind and Dampness stagnate and transform over time.

Critically, as the pathogenic factors linger, they begin to affect the Blood. Wind dries and consumes Blood, while Heat enters the Blood level, making the skin poorly nourished and increasingly irritable. This creates a vicious cycle: depleted Blood fails to nourish the skin, which becomes more vulnerable to Wind invasion. The formula therefore must address all three pathogenic layers (Wind, Dampness, Heat) simultaneously while protecting and nourishing the Blood to break this cycle and allow the skin to heal.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly pungent and bitter, with a sweet undertone. The pungent herbs disperse Wind and open the skin's pores, the bitter herbs dry Dampness and clear Heat, and the sweet herbs nourish Blood and harmonize the formula.

Channels Entered

Ingredients

13 herbs

The herbs that make up Xiao Feng San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Jing Jie

Jing Jie

Japanese catnip

Dosage 6 - 10g
Temperature Neutral
Taste Pungent
Organ Affinity Liver, Lungs

Role in Xiao Feng San

Opens the interstices and pores, disperses Wind from the skin surface, and relieves itching. Jing Jie is particularly valued for its ability to expel Wind from the Blood level.
Fang Feng

Fang Feng

Saposhnikovia roots

Dosage 6 - 10g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Urinary Bladder, Liver, Spleen

Role in Xiao Feng San

Disperses Wind and releases the exterior, working synergistically with Jing Jie to unblock the pores and expel Wind pathogens lodged in the skin and muscle layer.
Niu Bang Zi

Niu Bang Zi

Greater burdock fruits

Dosage 6 - 10g
Temperature Cold
Taste Bitter, Pungent
Organ Affinity Lungs, Stomach

Role in Xiao Feng San

Disperses Wind-Heat, vents rashes to the surface, clears toxins, and benefits the throat. Helps drive Wind pathogens outward through the skin.
Chan Tui

Chan Tui

Cicada sloughs

Dosage 6 - 10g
Temperature Cold
Taste Bitter, Salty
Organ Affinity Liver, Lungs

Role in Xiao Feng San

Disperses Wind-Heat, vents rashes, and relieves itching. Its light, ascending nature helps push Wind pathogens out through the skin surface.
Deputies — Assists and enhances the King
Cang Zhu

Cang Zhu

Black atractylodes rhizomes

Dosage 6 - 10g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Spleen, Stomach

Role in Xiao Feng San

Dries Dampness with its bitter, warm, and aromatic nature. Addresses the Dampness component that causes weeping and oozing of the skin lesions.
Ku Shen

Ku Shen

Sophora roots

Dosage 6 - 10g
Temperature Cold
Taste Bitter
Organ Affinity Urinary Bladder, Heart, Large Intestine, Liver, Stomach

Role in Xiao Feng San

Clears Heat and dries Dampness, with a specific affinity for the skin. One of the most effective herbs for stopping Damp-Heat itching.
Mu Tong

Mu Tong

Akebia stems

Dosage 3 - 6g
Temperature Cold
Taste Bitter
Organ Affinity Heart, Lungs, Small Intestine

Role in Xiao Feng San

Promotes urination to drain Damp-Heat downward and out of the body through the urine, providing an exit route for the pathogenic Dampness trapped in the skin.
Shi Gao

Shi Gao

Gypsum

Dosage 6 - 10g
Temperature Cold
Taste Pungent, Sweet
Organ Affinity Lungs, Stomach

Role in Xiao Feng San

Clears Heat from the Qi level and drains Fire, addressing the Heat component responsible for redness, burning sensations, and inflammation of the skin.
Zhi Mu

Zhi Mu

Anemarrhena rhizomes

Dosage 6 - 10g
Temperature Cold
Taste Bitter, Sweet
Organ Affinity Kidneys, Lungs, Stomach

Role in Xiao Feng San

Clears Heat and nourishes Yin fluids, working with Shi Gao to clear interior Heat while also preventing the drying herbs in the formula from further depleting fluids.
Assistants — Supports or moderates other herbs
Dang Gui

Dang Gui

Dong quai

Dosage 6 - 10g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Heart, Liver, Spleen

Role in Xiao Feng San

Nourishes and invigorates the Blood, embodying the classical principle of 'to treat Wind, first treat the Blood; when Blood flows, Wind naturally subsides.' Also counterbalances the drying tendency of the Wind-dispersing and Dampness-drying herbs.
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 6 - 10g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Xiao Feng San

Cools the Blood and nourishes Yin. Its cold nature directly addresses Blood-level Heat that manifests as red, inflamed skin, while its moistening quality prevents the formula from being too drying.
Hei Zhi Ma

Hei Zhi Ma

Black sesame seeds

Dosage 6 - 10g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Xiao Feng San

Nourishes the Blood, moistens dryness, and replenishes Yin fluids. Supports skin repair and prevents the Wind-dispersing and Dampness-drying herbs from excessively drying the skin and Blood.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Liquorice

Dosage 3 - 6g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Xiao Feng San

Clears Heat, resolves toxins, and harmonizes all the other herbs in the formula. Moderates the harsh properties of the other ingredients and helps unify their combined actions.

Why This Combination Works

How the herbs in Xiao Feng San complement each other

Overall strategy

This formula addresses a complex condition where Wind, Dampness, and Heat have all invaded the skin and become trapped in the interstices (the space between skin and muscle). The prescription strategy combines four therapeutic approaches: dispersing Wind to relieve itching, clearing Heat to reduce inflammation, draining Dampness to stop oozing, and nourishing Blood to prevent the drying herbs from injuring the body's fluids and to treat the root cause of vulnerability to Wind.

King herbs

Jing Jie, Fang Feng, Niu Bang Zi, and Chan Tui together form the King group. Their primary role is to open the pores and interstices of the skin, allowing the trapped Wind pathogen to be vented outward. This directly addresses the dominant symptom of itching, following the classical teaching: "Itching comes from Wind; to stop itching, one must first disperse Wind." Jing Jie is especially effective at expelling Wind from the Blood level, while Chan Tui and Niu Bang Zi also help vent rashes and clear Heat-toxins.

Deputy herbs

Five herbs serve as Deputies, addressing the Dampness and Heat that accompany the Wind. Cang Zhu dries Dampness with its warm, aromatic nature. Ku Shen clears Heat and dries Dampness specifically in the skin, making it highly effective for itchy, weeping lesions. Mu Tong provides a downward drainage route for Damp-Heat through the urine. Shi Gao and Zhi Mu clear Heat from the Qi level, reducing the internal fire that manifests as redness and inflammation on the skin.

Assistant herbs

Dang Gui, Sheng Di Huang, and Hei Zhi Ma (Hu Ma Ren) are restraining Assistants that serve a dual purpose. First, they nourish and cool the Blood, applying the time-honored principle: "To treat Wind, first treat the Blood; when Blood circulates freely, Wind naturally subsides" (治风先治血,血行风自灭). Second, their moistening, Yin-nourishing properties counterbalance the drying effects of the Wind-dispersing and Dampness-drying herbs, preventing the formula from causing further damage to the skin and body fluids. Sheng Di Huang (raw Rehmannia) specifically cools Blood-level Heat, while Dang Gui invigorates Blood circulation.

Envoy herbs

Gan Cao (Licorice) serves as Envoy, clearing residual Heat-toxins and harmonizing the actions of all the other herbs. Its moderating nature helps reconcile the potentially conflicting properties within the formula, such as the warm, drying herbs and the cool, moistening herbs.

Notable synergies

The pairing of Jing Jie and Fang Feng is one of the most classic Wind-dispersing combinations in TCM, together opening the exterior powerfully. The combination of Shi Gao and Zhi Mu (from Bai Hu Tang logic) efficiently clears interior Heat. The triad of Dang Gui, Sheng Di Huang, and Hei Zhi Ma provides Blood-nourishing and Yin-protecting support that prevents the strongly dispersing and drying main herbs from causing further harm. The overall design of the formula demonstrates an elegant balance: it attacks the pathogen (Wind, Dampness, Heat) on three fronts while simultaneously protecting the body's vital substances (Blood and Yin).

How to Prepare

Traditional preparation instructions for Xiao Feng San

Decoct all 13 ingredients in approximately 400 ml (2 bowls) of water. Bring to a boil, then simmer until the liquid is reduced to about 300–320 ml (roughly 80% of the original volume). Strain and take the decoction warm, between meals (about 1–2 hours after eating). One dose per day, divided into two servings if desired.

During the course of treatment, spicy foods, seafood, alcohol, strong tea, and other irritating or heating foods should be strictly avoided, as they may worsen the skin condition and interfere with the formula's effectiveness.

Common Modifications

How practitioners adapt Xiao Feng San for specific situations

Added
Jin Yin Hua

9-15g, clears Heat and resolves toxins

Lian Qiao

9-12g, disperses Wind-Heat and clears toxins

When Wind-Heat is the dominant pathogen, the dose of Shi Gao should also be increased, and Jin Yin Hua and Lian Qiao are added to strengthen the formula's ability to clear Heat-toxins and disperse Wind-Heat from the exterior.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Xiao Feng San should not be used or requires extra caution

Avoid

Skin conditions due to Cold-deficiency or Yang deficiency (pale, cold skin without Heat signs). This formula contains multiple cooling and Heat-clearing herbs that would worsen Cold patterns.

Caution

Severe Qi or Blood deficiency. The formula's dispersing Wind-expelling herbs can further deplete Qi and Blood in already weakened patients.

Caution

Pre-existing kidney disease or impaired renal function. Mu Tong (Akebia stem) requires caution in patients with kidney problems. Historically, confusion between Mu Tong (Akebia) and the nephrotoxic Guan Mu Tong (Aristolochia manshuriensis, which contains aristolochic acid) has caused serious harm. Ensure the correct, non-toxic Mu Tong species is used.

Caution

Liver disease. Some of the cooling and bitter herbs may place additional burden on compromised liver function.

Caution

Active bleeding or patients on anticoagulant therapy. Dang Gui (Angelica sinensis) moves Blood, and Sheng Di Huang (raw Rehmannia) cools Blood, which may theoretically affect clotting.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Several herbs in this formula raise concern: - Mu Tong (Akebia stem) promotes urination and moves Blood; classical texts note it should be used cautiously in pregnancy. - Niu Bang Zi (Burdock seed) has a slippery, descending nature that is traditionally considered potentially problematic in pregnancy. - Cang Zhu (Atractylodes) is drying and aromatic, which may not be suitable for the Yin-nourishing requirements of pregnancy. - The overall dispersing and cooling nature of the formula is generally not aligned with the need to secure and warm the fetus during pregnancy. Pregnant women should avoid this formula unless specifically prescribed by an experienced practitioner who has weighed the risks and benefits.

Breastfeeding

Use with caution during breastfeeding. The formula contains Ku Shen (Sophora root), which is very bitter and cold, and its constituents may transfer into breast milk and potentially cause digestive upset in infants. Mu Tong classically promotes lactation but also drains fluids through urination, which could theoretically affect milk volume. Shi Gao (Gypsum) and Zhi Mu (Anemarrhena) are cold-natured and could affect the infant's digestion if significant amounts enter the milk. No well-documented adverse breastfeeding events have been reported, but because data is limited, nursing mothers should use this formula only under the guidance of a qualified practitioner, ideally at reduced dosage and for the shortest effective duration.

Children

Xiao Feng San has been used in children historically. The original text in the Wai Ke Zheng Zong explicitly mentions treating both adults and children (大人小儿) for Wind-Heat urticaria. For pediatric use: - Dosage should be reduced according to age and body weight, typically to one-third to one-half of the adult dose for children over 6 years, and further reduced for younger children. - The bitter and cold herbs (Ku Shen, Shi Gao, Zhi Mu) may be harsh on a child's immature digestive system. Watch for loose stools, reduced appetite, or stomach discomfort. - Mu Tong should be used at minimal dosage or substituted with the milder Tong Cao in pediatric formulations. - Not generally recommended for infants or toddlers under 3 without specialist supervision. - The clinical trial by Cheng et al. (2011) included patients as young as 8 years with good tolerability.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Xiao Feng San

Gan Cao (Licorice root) in this formula may interact with several drug classes:

  • Antihypertensives and diuretics: Glycyrrhizin in licorice can cause sodium retention and potassium loss, potentially counteracting blood pressure medications and increasing the risk of hypokalemia when combined with thiazide or loop diuretics.
  • Corticosteroids: Licorice may potentiate the effects of corticosteroids by inhibiting cortisol metabolism, which is particularly relevant for dermatology patients already using topical or oral steroids.
  • Digoxin and cardiac glycosides: Licorice-induced hypokalemia can increase sensitivity to digoxin toxicity.

Dang Gui (Angelica sinensis) has mild Blood-moving properties and coumarin content that may theoretically enhance the effects of anticoagulants (warfarin, heparin) or antiplatelet drugs (aspirin, clopidogrel), increasing bleeding risk.

Shi Gao (Gypsum, calcium sulfate) is a calcium-containing mineral that may reduce the absorption of tetracycline antibiotics and fluoroquinolones if taken simultaneously.

Mu Tong (Akebia stem) has diuretic properties and should be used cautiously alongside pharmaceutical diuretics to avoid excessive fluid and electrolyte loss.

General note: Patients taking immunosuppressants for dermatological conditions (e.g. cyclosporine, tacrolimus) should inform their practitioner, as the immunomodulatory effects of the formula may interact with these medications in unpredictable ways.

Usage Guidance

Practical advice for getting the most out of Xiao Feng San

Best time to take

Between meals (on a relatively empty stomach), typically 30–60 minutes after eating, twice daily. The classical instruction is 食远服 (take well after meals).

Typical duration

Acute flare-ups: 1–2 weeks; subacute or recurring conditions: 4–8 weeks with regular reassessment by a practitioner.

Dietary advice

Avoid spicy, pungent, and heavily seasoned foods (chili, pepper, garlic) as they generate Heat and may worsen skin inflammation. Avoid fishy and shellfish foods (shrimp, crab, certain fish), which are considered "hair-generating" (发物) foods in TCM that can trigger or aggravate skin eruptions. Avoid alcohol, strong tea, and coffee, which produce Dampness and Heat internally. Avoid greasy, deep-fried, and rich foods that generate Dampness. Favor light, easily digestible foods such as mung bean soup, fresh vegetables, and cooling foods like cucumber, winter melon, and barley (Yi Yi Ren) congee, which help clear Heat and drain Dampness.

Xiao Feng San originates from Wài Kē Zhèng Zōng (外科正宗, Orthodox Lineage of External Medicine) by Chén Shí Gōng (陈实功) Míng dynasty, 1617 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Xiao Feng San and its clinical use

Original text from the Wai Ke Zheng Zong (《外科正宗》), Volume 4, by Chen Shigong (陈实功):

「治风湿浸淫血脉,致生疥疮,瘙痒不绝,及大人小儿风热瘾疹,遍身云片斑点,乍有乍无并效。」

Translation: "Treats Wind-Dampness that soaks into the blood vessels, giving rise to scabies and sores with unrelenting itching, as well as Wind-Heat urticaria in adults and children, with cloud-like patches and spots appearing all over the body that come and go intermittently."

Classical teaching on the treatment principle:

「痒自风来,止痒必先疏风。」

Translation: "Itching comes from Wind; to stop itching, one must first disperse Wind."

Classical teaching on Blood and Wind:

「治风先治血,血行风自灭。」

Translation: "To treat Wind, first treat the Blood; when Blood flows freely, Wind naturally subsides."

This widely cited principle, found across multiple classical sources, explains why Xiao Feng San includes Blood-nourishing herbs alongside its Wind-dispersing ingredients.

Historical Context

How Xiao Feng San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Xiao Feng San originates from the Wai Ke Zheng Zong (《外科正宗》, "Orthodox Lineage of External Medicine"), written by the Ming dynasty surgeon Chen Shigong (陈实功, 1555–1636) and published in 1617. Chen was from Chongchuan (modern-day Nantong, Jiangsu province) and is regarded as one of the foremost external medicine specialists in Chinese medical history. The Qing dynasty physician Xu Lingtai praised this text as the ideal first book for anyone studying external medicine.

Importantly, the name "Xiao Feng San" appears in many different texts with entirely different compositions. The earlier Tai Ping Hui Min He Ji Ju Fang (Song dynasty formulary) contains a very different Xiao Feng San aimed at Wind attacking the head with dizziness, tinnitus, and facial numbness. Chen Shigong's version was innovative in its comprehensive approach: rather than treating Wind alone, he recognized the complex interplay of Wind, Dampness, Heat, and Blood deficiency in skin disease, and designed a formula that addresses all four aspects simultaneously. This made his version far more clinically effective for dermatological conditions, and it eclipsed earlier formulas of the same name.

A modern safety note concerns Mu Tong in the formula. The original formula uses Mu Tong from the Akebia family, which does not contain aristolochic acid. However, in the 20th century, some manufacturers substituted the nephrotoxic Guan Mu Tong (from Aristolochia manshuriensis) due to confusion in nomenclature. Following the widely publicized kidney damage cases linked to aristolochic acid (notably the Long Dan Xie Gan Wan incident in 2003), China's drug regulatory authority banned Guan Mu Tong and mandated the use of the safe Akebia-derived Mu Tong. Modern formulations often substitute Tong Cao (Tetrapanax papyriferus, rice paper plant pith) for Mu Tong to avoid any risk entirely.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Xiao Feng San

1

RCT: Xiao-Feng-San for Refractory Atopic Dermatitis (2011)

Cheng HM, Chiang LC, Jan YM, Chen GW, Li TC. International Archives of Allergy and Immunology, 2011, 155(2): 141-148.

A double-blind, placebo-controlled trial enrolled 71 patients with severe, treatment-resistant atopic dermatitis in Taiwan. After 8 weeks of oral Xiao Feng San, the treatment group showed a 79.7% reduction in total lesion score compared to 13.5% in the placebo group (p < 0.001). Significant improvements were also seen in erythema, surface damage, itching, and sleep quality, with benefits persisting 4 weeks after treatment ended. No evidence of liver or kidney toxicity was found.

Link
2

RCT: Xiao-Feng-San Combined with Auricular Acupuncture for Atopic Dermatitis (2025)

Journal of Integrative and Complementary Medicine (Elsevier), 2025. [Randomized sham-controlled trial, 156 participants]

A randomized, sham-controlled trial of 156 adults with non-severe atopic dermatitis of the Wind-Dampness-Heat pattern. All patients received Xiao Feng San decoction, with one group also receiving auricular acupuncture and the other sham acupuncture. At week 4, the combined treatment group showed significantly greater reduction in SCORAD index (mean difference of -9.1, p < 0.0001), with improved quality of life and a favorable safety profile.

Link
3

Systematic Review Protocol: Xiao Feng San for Urticaria (2018)

Chen G, Zhao J, Chen T, Zhang Z, Huang C, Xu Z, Xu H. Medicine, 2018, 97(47): e13344.

A registered systematic review protocol (PROSPERO CRD42018087260) was developed to evaluate the efficacy and safety of Xiao Feng San for urticaria across seven databases. The protocol noted that Xiao Feng San is one of the most commonly prescribed Chinese herbal formulas for urticaria in Taiwan and mainland China, and aimed to synthesize evidence from randomized controlled trials comparing it to conventional Western treatments.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.