Formula Pill (Wan)

Qing Qi Hua Tan Wan

Clear Qi and Transform Phlegm Pill · 清氣化痰丸

Also known as: Qing Qi Hua Tan Tang, Clear the Qi and Transform Phlegm Pill

A classical formula for coughs with thick, sticky, yellow phlegm caused by Heat and Phlegm congesting the Lungs. It clears Heat, breaks down stubborn Phlegm, and restores the normal downward flow of Lung Qi to relieve coughing, chest fullness, and wheezing.

Origin Yi Fang Kao (醫方考, Investigations of Medical Formulas) by Wu Kun — Míng dynasty, 1584 CE
Composition 8 herbs
Da
King
Dan Nan Xing (Bile-processed Arisaema)
Gua Lou Ren
King
Gua Lou Ren
Ban Xia
Deputy
Ban Xia
Huang Qin
Deputy
Huang Qin
Xing Ren
Assistant
Xing Ren
Zhi Shi
Assistant
Zhi Shi
Chen Pi
Assistant
Chen Pi
Fu Ling
Assistant
Fu Ling
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qing Qi Hua Tan Wan is designed to correct these specific patterns.

Why Qing Qi Hua Tan Wan addresses this pattern

Phlegm-Heat in the Lungs is the primary pattern this formula treats. When internal Heat (from emotional stress, diet, or external pathogens transforming into Heat) combines with Phlegm, the Lung's normal descending and purifying function is blocked. The Heat thickens normal fluids into sticky, yellow Phlegm that is hard to expectorate, while the Phlegm obstruction prevents Qi from flowing properly, causing cough, wheezing, and chest tightness.

Qing Qi Hua Tan Wan addresses every dimension of this pattern. Dan Nan Xing and Gua Lou Ren directly clear Heat-Phlegm from the Lungs. Huang Qin drains the Fire fueling Phlegm production. Ban Xia dissolves the already-formed Phlegm. Xing Ren, Zhi Shi, and Chen Pi restore proper Qi movement. Fu Ling strengthens Spleen function to stop new Phlegm from forming. The combined effect is that Heat is cleared, Qi descends properly, and Phlegm resolves.

A practitioner would look for one or more of these signs

Hypochondrial Pain That Is Worse On Coughing And Breathing

Productive cough with thick, sticky, yellow phlegm that is difficult to expectorate

Wheezing

Wheezing or shortness of breath due to Phlegm obstruction

Chest Stiffness

Feeling of fullness, stuffiness, or oppression in the chest and diaphragm area

Nausea

Nausea or retching triggered by upward-surging Qi from Phlegm obstruction

Restlessness

Irritability and restlessness caused by Phlegm-Heat disturbing the Spirit

Copious Thick Yellow Sputum

Sputum that is distinctly yellow, thick, and viscid

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Qing Qi Hua Tan Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, acute bronchitis is most often understood as an external pathogen (such as Wind-Heat or Wind-Cold that transforms into Heat) invading the Lungs and disrupting their descending and purifying function. When the Lung's ability to move fluids is compromised and Heat is present, normal thin fluids thicken and congeal into Phlegm. This Phlegm obstructs the airways, triggering cough and wheezing. The Heat component explains the yellow color and sticky texture of the sputum, as well as accompanying symptoms like dry mouth, sore throat, and irritability.

Why Qing Qi Hua Tan Wan Helps

Qing Qi Hua Tan Wan directly targets the Phlegm-Heat mechanism underlying acute bronchitis. Dan Nan Xing and Gua Lou Ren powerfully dissolve the thick, sticky Phlegm clogging the airways. Huang Qin clears the Heat driving Phlegm formation and has demonstrated antibacterial properties in modern research. Xing Ren restores the Lung's natural downward Qi flow to relieve coughing and wheezing. Ban Xia further dissolves Phlegm and calms the rebellious upward Qi that causes the cough reflex. Fu Ling and Chen Pi address the Spleen's role in Phlegm production, preventing recurrence.

Also commonly used for

Upper Respiratory Tract Infections

With productive cough and yellow sputum

Bronchiectasis

With copious yellow-green sputum and Heat signs

Chronic Obstructive Pulmonary Disease

During acute exacerbations with Phlegm-Heat

Hypochondrial Pain That Is Worse On Coughing And Breathing

Productive cough with thick yellow phlegm as the dominant symptom

Sinusitis

With thick yellow nasal discharge and Phlegm-Heat signs

What This Formula Does

Every TCM formula has a specific set of actions — here's what Qing Qi Hua Tan Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Qing Qi Hua Tan Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Qing Qi Hua Tan Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Qing Qi Hua Tan Wan works at the root level.

This formula addresses a condition where Heat and Phlegm have become bound together inside the body, particularly in the Lungs. The underlying mechanism typically begins with stagnant Qi. When Qi circulation becomes obstructed (from emotional stress, dietary excess, or other causes), the blocked Qi generates internal Heat or Fire over time. This Fire then "cooks" the body's normal fluids, thickening them into sticky, concentrated Phlegm. At the same time, pre-existing Dampness from a sluggish Spleen provides raw material that Fire readily condenses into Phlegm. The result is a vicious cycle: Phlegm and Heat reinforce each other.

When this Phlegm-Heat lodges in the Lungs, it blocks the Lungs' natural descending function. The Lungs can no longer send Qi smoothly downward, leading to coughing, wheezing, and a feeling of fullness or stuffiness in the chest. The Phlegm produced is thick, yellow, and sticky, difficult to cough up. If Phlegm-Heat disrupts Stomach Qi (which also normally descends), there may be nausea or vomiting. If it disturbs the Heart-Spirit, irritability and restlessness can occur. The tongue is red with a yellow greasy coating, and the pulse is slippery and rapid, both classic signs of Phlegm-Heat.

The formula works by simultaneously clearing the Heat, dissolving the Phlegm, and restoring the normal downward flow of Qi. Because the root of the problem lies in disordered Qi generating Fire that produces Phlegm, the classical teaching emphasizes that "transforming Phlegm must begin with clearing the Qi" (化痰必以清气为先). When the Qi mechanism is restored, Fire naturally subsides; when Fire subsides, Phlegm has nothing to sustain it and dissolves.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter and pungent, with some sweetness. The bitterness clears Heat and dries Dampness, the pungency opens and moves stagnant Qi and Phlegm, and the mild sweetness from Fu Ling and Gua Lou Ren supports the Spleen and moistens.

Channels Entered

Ingredients

8 herbs

The herbs that make up Qing Qi Hua Tan Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Kings — Main ingredient driving the formula
Da

Dan Nan Xing (Bile-processed Arisaema)

Dosage 6 - 9g

Role in Qing Qi Hua Tan Wan

Bitter and cool, Dan Nan Xing is the primary Phlegm-transforming herb in this formula. Processed with bile, it powerfully clears Heat-Phlegm and resolves thick, stubborn mucus congesting the Lungs. Its bile processing reduces the drying, toxic nature of raw Tian Nan Xing while enhancing its ability to clear Heat and dissolve Phlegm.
Gua Lou Ren

Gua Lou Ren

Trichosanthes seed

Dosage 6 - 9g
Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Lungs, Stomach, Large Intestine
Preparation Defatted (去油) to form Gua Lou Ren Shuang (frost)

Role in Qing Qi Hua Tan Wan

Sweet and cold with a moist, slippery quality, Gua Lou Ren clears Heat from the Lungs and transforms Phlegm. It can also guide Phlegm-Heat downward to be expelled through the bowels, providing a second route of elimination. Working alongside Dan Nan Xing, it reinforces the core strategy of clearing Heat while dissolving Phlegm.
Deputies — Assists and enhances the King
Ban Xia

Ban Xia

Pinellia tuber

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs

Role in Qing Qi Hua Tan Wan

Although warm in nature, processed Pinellia is a powerful Phlegm-transforming and Qi-descending herb. When paired with the cold Huang Qin, its warmth is tempered while its ability to dissolve Phlegm masses and stop vomiting is fully utilized. It strongly assists the King herbs in breaking down the Phlegm that has already formed.
Huang Qin

Huang Qin

Chinese skullcap root

Dosage 6 - 9g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach
Preparation Wine-fried (酒炒)

Role in Qing Qi Hua Tan Wan

Bitter and cold, Huang Qin excels at clearing Heat and draining Fire from the Lungs. It directly addresses the Heat component of the Phlegm-Heat pathology and restrains the warm nature of Ban Xia, creating a complementary pairing that is both mutually reinforcing and mutually moderating.
Assistants — Supports or moderates other herbs
Xing Ren

Xing Ren

Bitter apricot kernel

Dosage 6 - 9g
Temperature Slightly Warm
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Large Intestine

Role in Qing Qi Hua Tan Wan

Descends and diffuses Lung Qi to address the upper body, relieving cough and wheezing. By restoring the Lung's natural downward-directing function, it helps move Phlegm out and stops the counterflow of Qi that causes coughing.
Zhi Shi

Zhi Shi

Immature bitter orange

Dosage 6 - 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn), Sour (酸 suān)
Organ Affinity Spleen, Stomach, Large Intestine
Preparation Bran-fried (麸炒)

Role in Qing Qi Hua Tan Wan

Breaks up Qi stagnation and dissolves Phlegm accumulation, relieving the feeling of chest fullness and tightness. Its strong Qi-moving action helps open the chest and restore normal Qi circulation, which is essential because stagnant Qi and Phlegm reinforce each other.
Chen Pi

Chen Pi

Tangerine peel

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Spleen

Role in Qing Qi Hua Tan Wan

Regulates Qi in the middle portion of the body and dries Dampness to transform Phlegm. It smooths the Qi mechanism in the digestive area and assists in preventing new Phlegm formation by addressing Dampness at its source.
Fu Ling

Fu Ling

Poria

Dosage 6 - 9g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Qing Qi Hua Tan Wan

Strengthens the Spleen and drains Dampness through urination, cutting off Phlegm at its source. TCM teaches that the Spleen is the organ that produces Phlegm, so supporting Spleen function and removing Dampness prevents new Phlegm from forming.

Why This Combination Works

How the herbs in Qing Qi Hua Tan Wan complement each other

Overall strategy

This formula targets Phlegm-Heat congesting the Lungs, a condition where Fire has thickened normal body fluids into stubborn, sticky Phlegm. The prescription strategy combines three approaches simultaneously: clearing Heat to remove the cause, dissolving the existing Phlegm, and regulating Qi flow to restore the Lung's descending function and prevent Phlegm from re-forming.

King herbs

Dan Nan Xing (bile-processed Arisaema) and Gua Lou Ren (trichosanthes seed) share the King role. Dan Nan Xing is bitter and cool, making it exceptionally effective at clearing Heat and dissolving thick, sticky Phlegm in the Lungs. Gua Lou Ren is sweet and cold with a moistening quality. It clears Lung Heat and transforms Phlegm, and can also guide Phlegm-Heat downward to be expelled through the bowels. Together they mount a two-pronged attack on Phlegm-Heat from above and below.

Deputy herbs

Zhi Ban Xia (processed Pinellia) and Huang Qin (Scutellaria) form a carefully balanced pairing. Ban Xia is warm and excels at dissolving Phlegm and descending rebellious Qi, while Huang Qin is cold and drains Fire from the Lungs. Paired together, Huang Qin restrains Ban Xia's warmth so it won't aggravate the Heat, while Ban Xia's Phlegm-dissolving power is fully harnessed. They are both mutually reinforcing and mutually moderating.

Assistant herbs

Four Assistant herbs each address a different angle. Xing Ren (apricot seed) descends Lung Qi to relieve cough and wheezing (reinforcing assistant, targeting the upper body). Zhi Shi (immature bitter orange) breaks up Qi stagnation and opens the chest (reinforcing assistant, targeting Phlegm obstruction). Chen Pi (tangerine peel) regulates Qi flow in the middle body and dries residual Dampness (reinforcing assistant, smoothing Qi circulation). Fu Ling (Poria) strengthens the Spleen and drains Dampness, cutting off Phlegm production at its root (reinforcing assistant, addressing the underlying Dampness).

Envoy herbs

Ginger juice (Jiang Zhi) serves as the Envoy by binding the pills together and by opening up the Phlegm pathway. It also moderates the toxicity of Ban Xia and enhances the formula's ability to descend Qi and disperse Phlegm.

Notable synergies

The Ban Xia and Huang Qin pairing is the formula's most elegant combination: warm and cold, Phlegm-dissolving and Fire-draining, they check and complement each other perfectly. The trio of Chen Pi, Ban Xia, and Fu Ling echoes the core of Er Chen Tang (Two Aged Ingredients Decoction), the classical foundation for Phlegm treatment, ensuring the formula addresses Dampness and Phlegm at the Spleen level while the King herbs handle the Heat component in the Lungs.

How to Prepare

Traditional preparation instructions for Qing Qi Hua Tan Wan

The original preparation is as pills (丸). The eight herbs (except Gua Lou Ren, which is pressed into a defatted powder called Gua Lou Ren Shuang) are ground into a fine powder and mixed with the Gua Lou Ren powder. Fresh ginger (approximately 100g) is crushed and pressed to extract the juice, which is then mixed with the herbal powder to form small pills by the water-pill method (泛丸). The pills are dried thoroughly.

The standard adult dose is 6 to 9 grams taken twice daily with warm water. Children's doses should be reduced proportionally. The formula may also be prepared as a decoction (汤剂) by adding 3 slices of fresh ginger and boiling with water, using proportionally reduced amounts of each herb.

Common Modifications

How practitioners adapt Qing Qi Hua Tan Wan for specific situations

Added
Shi Gao

15 - 30g, strongly clears Lung Heat and drains Fire

Zhi Mu

9 - 12g, clears Heat and nourishes Yin to prevent fluid damage

When Heat predominates over Phlegm, Shi Gao and Zhi Mu powerfully drain Lung Fire, addressing the root cause of Phlegm formation and relieving fever and thirst.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Qing Qi Hua Tan Wan should not be used or requires extra caution

Avoid

Cold-Phlegm or Damp-Phlegm cough with thin, white, copious sputum and a white greasy tongue coating. This formula targets Phlegm-Heat and would be inappropriate (and potentially worsening) for cold-type Phlegm conditions.

Avoid

Yin-deficiency dry cough with little or no phlegm. The formula's predominantly bitter and drying nature would further injure Yin fluids.

Avoid

Pregnancy. The formula contains Ban Xia (Pinellia) and Zhi Shi (Immature Bitter Orange), both traditionally cautioned against during pregnancy due to their strong descending and Qi-breaking actions.

Caution

Spleen and Stomach deficiency-cold with loose stools and poor appetite. The cold, bitter herbs in this formula can further impair weak digestive function. If loose stools develop during use, dosage should be reduced or the formula discontinued.

Caution

Exterior Wind-Cold patterns at early onset. This formula treats interior Phlegm-Heat and should not be used when a person has chills, body aches, and thin white tongue coating indicating an unresolved surface-level cold invasion.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The formula contains Ban Xia (Pinellia), which is traditionally listed among herbs prohibited in pregnancy due to potential embryotoxicity. Zhi Shi (Immature Bitter Orange) has strong Qi-breaking and descending actions that could theoretically stimulate uterine contractions. Dan Nan Xing (Bile-Processed Arisaema) also carries traditional pregnancy cautions. Pregnant women should not use this formula.

Breastfeeding

No specific classical prohibitions exist for breastfeeding, but caution is advised. Ban Xia (Pinellia) and Dan Nan Xing (Bile-Processed Arisaema) are potent herbs whose transfer through breast milk has not been studied. The formula's cold, bitter, and drying properties could theoretically reduce milk production or cause digestive upset in a nursing infant. Breastfeeding mothers should use this formula only under professional guidance and for the shortest duration necessary.

Children

Qing Qi Hua Tan Wan can be used in children but with reduced dosage appropriate to age and body weight. Classical sources note "children should reduce the dose" (小儿酌减). General guidelines: children under 3 years old should use roughly one-quarter of the adult dose; ages 3-7 approximately one-third; ages 7-14 approximately one-half. The pill form can be crushed and mixed with warm water for younger children who cannot swallow pills. Because the formula is cold and bitter in nature, it should not be used long-term in children whose digestion is still developing. A practitioner should monitor for loose stools or reduced appetite, which signal that the formula is too cold for the child's constitution.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Qing Qi Hua Tan Wan

Huang Qin (Scutellaria baicalensis): Contains the flavonoid baicalin, which has been shown to inhibit certain cytochrome P450 enzymes (including CYP1A2 and CYP3A4) and may affect the metabolism of drugs processed through these pathways, including some antibiotics, anticoagulants, and sedatives. Baicalin may also potentiate the effects of antibiotics, so concurrent use with antibiotic therapy should be monitored.

Ban Xia (Pinellia ternata): May interact with sedative or anti-nausea medications, potentially enhancing their effects due to its own anti-emetic properties.

Ku Xing Ren (Bitter Apricot Seed): Contains amygdalin, which can release small amounts of hydrogen cyanide. In normal therapeutic doses this is safe, but caution is warranted if combined with other cyanogenic substances. Patients taking antitussive medications should be aware of potentially additive cough-suppressant effects.

General: Patients taking anticoagulant or antiplatelet medications should consult their healthcare provider, as Huang Qin has demonstrated mild anticoagulant activity in pharmacological studies.

Usage Guidance

Practical advice for getting the most out of Qing Qi Hua Tan Wan

Best time to take

30 minutes after meals, twice daily, with warm water. Taking after meals protects the Stomach from the formula's cold, bitter properties.

Typical duration

Acute use: 3-7 days for acute respiratory infections with yellow phlegm. May be extended to 1-2 weeks for subacute or lingering coughs, reassessed by a practitioner.

Dietary advice

Avoid greasy, fried, and fatty foods, as these generate Dampness and Phlegm, directly counteracting the formula's effects. Also avoid overly sweet foods, dairy products, and cold or raw foods, all of which burden the Spleen and promote further Phlegm production. Spicy and heating foods (chili, alcohol, lamb) should be limited, as they may aggravate the Heat component of the condition. Favour light, easy-to-digest meals such as congee with daikon radish, pear (lightly stewed), and leafy greens. Adequate warm water intake helps thin mucus secretions.

Qing Qi Hua Tan Wan originates from Yi Fang Kao (醫方考, Investigations of Medical Formulas) by Wu Kun Míng dynasty, 1584 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Qing Qi Hua Tan Wan and its clinical use

Wu Kun (吴昆), Yi Fang Kao (《医方考》), Phlegm Chapter (痰门):

「气之不清,痰之故也,能治其痰,则气清矣。是方也,星、夏所以燥痰湿,杏、陈所以利痰滞,枳实所以攻痰积,黄芩所以消痰热,茯苓之用,渗痰湿也;若栝蒌者,则下气利痰云尔。」

"When the Qi is unclear, it is because of Phlegm. If one can treat the Phlegm, then the Qi becomes clear. In this formula, [Dan Nan] Xing and [Ban] Xia dry Phlegm-Dampness; [Ku Xing] Ren and Chen [Pi] free Phlegm stagnation; Zhi Shi attacks Phlegm accumulation; Huang Qin dispels Phlegm-Heat; Fu Ling percolates away Phlegm-Dampness; and Gua Lou descends Qi and frees Phlegm."


Wang Ang (汪昂), Yi Fang Ji Jie (《医方集解》), Chapter on Phlegm-Eliminating Formulas (除痰之剂):

「此手足太阴之药,治痰火之通剂也。气能发火,火能役痰……盖气之亢则为火,火退则还为正气而安其位矣,故化痰必以清气为先也。」

"This is a formula for the Hand and Foot Taiyin [Lung and Spleen] channels, a universal formula for treating Phlegm-Fire. Qi can generate Fire, and Fire can drive Phlegm… When Qi becomes excessive it transforms into Fire; when Fire recedes, it returns to normal Qi and settles back into its proper place. Therefore, transforming Phlegm must begin with clearing the Qi."

Historical Context

How Qing Qi Hua Tan Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Qing Qi Hua Tan Wan was first recorded in the Yi Fang Kao (《医方考》, "Investigations of Medical Formulas") by Wu Kun (吴昆), published in 1584 during the Ming Dynasty. Wu Kun was a physician from Anhui province known for his systematic, analytical approach to formulas. His Yi Fang Kao was groundbreaking as one of the first works to provide detailed critical analysis of why each formula works, covering over 780 prescriptions organized by disease category.

The formula itself is an elaboration of the earlier Er Chen Tang (二陈汤), the classical base formula for treating Phlegm. Wu Kun removed Gan Cao (licorice) and Wu Mei (smoked plum) from Er Chen Tang and added Dan Nan Xing, Gua Lou Ren, Huang Qin, Ku Xing Ren, and Zhi Shi. This transformed a mild, neutral Phlegm-resolving formula into a targeted treatment for Phlegm-Heat. The conceptual foundation draws on the influential ideas of Zhu Danxi (朱丹溪), the Jin-Yuan era physician who championed the principle "treat Phlegm by treating Qi" (善治痰者,不治痰而治气), reflecting the understanding that disordered Qi is the root cause of Phlegm production.

The later commentator Wang Ang (汪昂) in his Yi Fang Ji Jie (《医方集解》, 1682) called it "a universal formula for Phlegm-Fire" (治痰火之通剂) and provided an influential analysis of how each herb addresses a different aspect of Qi dysfunction. Today, Qing Qi Hua Tan Wan remains one of the most commonly used Chinese patent medicines for respiratory conditions with yellow, sticky phlegm, and is listed in the Chinese Pharmacopoeia.