Herb Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)

Zi Su Zi

Perilla fruit · 紫苏子

Perilla frutescens (L.) Britt. · Fructus Perillae

Also known as: Su Zi (苏子), Hei Su Zi (黑苏子), Tie Su Zi (铁苏子),

Images shown are for educational purposes only

Perilla fruit is a warm, gently oily seed used primarily to ease wheezing and coughing caused by phlegm buildup in the chest. It works by redirecting Qi downward and dissolving accumulated phlegm, and its natural oil content also helps relieve constipation. It is especially popular in formulas for elderly patients with chronic cough, breathing difficulty, and digestive sluggishness.

TCM Properties

Temperature

Warm

Taste

Acrid / Pungent (辛 xīn)

Channels entered

Lungs, Large Intestine

Parts used

Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)

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What This Herb Does

Every herb has a specific set of actions — here's what Zi Su Zi does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Zi Su Zi is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Zi Su Zi performs to restore balance in the body:

How these actions work

'Descends Qi and resolves Phlegm' means Zi Su Zi redirects Lung Qi downward when it is rebelliously surging upward. In TCM, the Lungs are supposed to send Qi downward. When phlegm accumulates and blocks the Lungs, Qi reverses direction and rises, causing wheezing, chest fullness, and copious sputum. Zi Su Zi's warm, acrid nature cuts through this accumulated cold phlegm while powerfully pushing the Qi back downward. As a classical source puts it, it is a key herb for "directing Qi downward and resolving phlegm" (降气消痰). This action is primarily used for cough and asthma with abundant thin, white sputum and a feeling of chest oppression.

'Relieves coughing and calms wheezing' follows directly from its Qi-descending action. Once rebellious Lung Qi is redirected downward and phlegm obstruction is cleared, the coughing and wheezing naturally resolve. This herb is especially suited for wheezing-predominant conditions rather than dry cough, and works best when phlegm is copious and the patient feels short of breath.

'Moistens the intestines and unblocks the bowels' refers to the herb's oil-rich nature. Perilla seeds contain approximately 45% fatty oil, which gently lubricates the intestinal wall and helps pass dry, hard stools. This makes it useful for constipation in elderly patients or those with Qi stagnation in the Lungs and Large Intestine, where the same downward-directing action benefits both the chest and the bowels simultaneously.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony. Zi Su Zi is used to help correct these specific patterns.

Why Zi Su Zi addresses this pattern

When cold phlegm accumulates in the Lungs, the normal downward flow of Lung Qi is blocked, causing it to rebel upward. This produces wheezing, cough with copious thin white sputum, and a sensation of chest fullness. Zi Su Zi directly addresses this mechanism through its warm, acrid nature: warmth disperses cold phlegm, while its strong Qi-descending action restores the Lungs' normal downward-directing function. Its entry into the Lung channel means it acts directly at the site of pathology. Among phlegm-resolving herbs, Zi Su Zi is particularly valued for its descending action, making it the first-choice herb when wheezing is the dominant symptom rather than cough alone.

A practitioner would look for one or more of these signs

Wheezing

Wheezing with copious thin white sputum

Hypochondrial Pain That Is Worse On Coughing And Breathing

Cough with chest oppression and fullness

Exertional Dyspnea

Shortness of breath, difficulty inhaling

Chest Congestion

Chest and diaphragm feeling blocked and stuffy

Commonly Used For

These are conditions where Zi Su Zi is frequently used — but only when they arise from the specific patterns it addresses, not in all cases

TCM Interpretation

TCM views asthma primarily as a disorder of Lung Qi failing to descend properly, with phlegm as the key obstructing factor. In many chronic asthma patients, especially those whose symptoms worsen in cold weather, the underlying mechanism involves cold phlegm lodging in the Lungs. This phlegm blocks the airways and forces Lung Qi to rebel upward, producing the characteristic wheezing and labored breathing. In cases of long-standing asthma, TCM also recognizes a 'lower deficiency' component where the Kidneys lose their ability to anchor the Qi that the Lungs send downward, creating a pattern of 'upper excess with lower deficiency' (上实下虚).

Why Zi Su Zi Helps

Zi Su Zi is one of the principal herbs for asthma because its core action directly targets the two main problems: rebellious Lung Qi and accumulated phlegm. Its warm nature disperses cold phlegm, while its powerful Qi-descending property restores the Lungs' normal function of sending Qi downward. Modern pharmacological studies on Perilla seed extracts have shown bronchospasmolytic effects, supporting its traditional use. In Su Zi Jiang Qi Tang, where it serves as the King herb, it works alongside half a dozen other herbs to address both the upper phlegm obstruction and the underlying Kidney Yang deficiency that perpetuates the asthma cycle.

Also commonly used for

Emphysema

Breathing difficulty with upper excess and lower deficiency pattern

Chronic Cough With Copious Sputum

Persistent productive cough in elderly patients

Exertional Dyspnea

Shortness of breath due to phlegm obstruction

Wheezing

Wheezing from cold-phlegm blocking the Lungs

Herb Properties

Every herb has an inherent temperature, taste, and affinity for specific channels — these properties determine how it interacts with the body

Temperature

Warm

Taste

Acrid / Pungent (辛 xīn)

Channels Entered

Lungs Large Intestine

Parts Used

Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)

Dosage & Preparation

These are general dosage guidelines for Zi Su Zi — always follow your practitioner's recommendation, as dosages vary based on the formula and your individual condition

Standard dosage

3-10g

Maximum dosage

Up to 15g in some clinical contexts for severe phlegm obstruction with wheezing, under practitioner supervision. This is a mild, food-grade herb with no significant toxicity concerns at therapeutic doses.

Dosage notes

Use lower doses (3-6g) when combining with other phlegm-resolving and Qi-descending herbs in a formula, as the combined effect is synergistic. Higher doses (6-10g) are appropriate when Zi Su Zi is the primary herb targeting severe cough with copious phlegm and chest oppression. For intestinal dryness with constipation, the full dose range (6-10g) is typically used to leverage the seed's oily, intestine-moistening quality. For patients with Spleen deficiency who need the Qi-descending action but cannot tolerate the intestine-lubricating effect, the processed form Su Zi Shuang (Perilla Seed Frost, with oil removed) can be used instead. Dry-frying (chao) moderates the seed's dispersing nature and enhances its warming, Lung-descending action. Honey-processing (mi zhi) adds a moistening, Lung-nourishing quality suited for deficiency-type cough.

Preparation

Best lightly crushed or cracked (捣碎) before decocting to release the oily contents and improve extraction of active components. Should not be boiled for too long, as prolonged decoction can degrade the aromatic and oily constituents. When used in San Zi Yang Qin Tang, the classical method wraps the crushed seeds in a gauze bag (包煎) to prevent the fine particles from clouding the decoction.

Processing Methods

In TCM, the same herb can be prepared in different ways to change its effects — here's how processing alters what Zi Su Zi does

Processing method

Clean perilla seeds are placed in a dry wok over gentle heat and stir-fried until they begin to pop and release a fragrant aroma, then removed and cooled.

How it changes properties

Stir-frying moderates the herb's descending action, making it less abrupt and gentler on the digestive system. The thermal nature remains warm but the overall effect becomes more moderate. The cracked seed coat also improves extraction of active compounds during decoction. This is the most commonly used form in clinical practice.

When to use this form

Preferred for most clinical applications involving phlegm-congested cough and wheezing, especially when treating patterns of upper excess with lower deficiency (as in Su Zi Jiang Qi Tang). Also preferred when the patient's constitution is somewhat weak and the raw herb's stronger descending action might be too aggressive.

Common Herb Pairs

These ingredients are traditionally combined with Zi Su Zi for enhanced therapeutic effect

Lai Fu Zi
Lai Fu Zi 1:1 (typically 9g each)

Zi Su Zi descends Lung Qi and resolves phlegm, while Lai Fu Zi (radish seed) excels at breaking down food stagnation and also promotes downward Qi movement. Together, they address the common clinical scenario where phlegm obstruction and food stagnation reinforce each other, producing both respiratory and digestive symptoms. Lai Fu Zi's food-dissolving action complements Zi Su Zi's phlegm-resolving strength.

When to use: Elderly patients with chronic cough, phlegm congestion, poor appetite, and bloating. This is the core pairing within San Zi Yang Qin Tang.

Bai Jie Zi
Bai Jie Zi 3:2 (e.g. Zi Su Zi 9g : Bai Jie Zi 6g)

Bai Jie Zi (white mustard seed) is a powerful phlegm-expelling herb that can reach phlegm lodged in hard-to-access areas like between the skin and membranes. While Zi Su Zi descends Qi and resolves phlegm from the Lungs, Bai Jie Zi penetrates more deeply to expel stubborn cold phlegm throughout the body. Together they provide comprehensive phlegm resolution from both the airways and the deeper tissue layers.

When to use: Cold-phlegm cough with wheezing, chest fullness, and flank pain. Also used in San Zi Yang Qin Tang alongside Lai Fu Zi.

Ban Xia
Ban Xia 1:1 (typically 9-10g each)

Ban Xia (Pinellia) is the premier herb for drying dampness and transforming phlegm, while Zi Su Zi excels at descending Qi. Together, Ban Xia dries and dissolves the phlegm while Zi Su Zi pushes the Qi downward, providing a powerful two-pronged approach. Ban Xia also has a strong anti-nausea effect, addressing any vomiting or nausea that accompanies the phlegm obstruction.

When to use: Phlegm-congested cough and wheezing with nausea, chest fullness, and copious white sputum. This is the core herb pair in Su Zi Jiang Qi Tang.

Huo Ma Ren
Huo Ma Ren 1:1 (typically 10-15g each)

Both herbs are oil-rich seeds that moisten the intestines. Zi Su Zi adds Qi-descending power to the physical lubrication, while Huo Ma Ren (hemp seed) is a gentle, neutral moistener without strong Qi-moving effects. Together they provide enhanced intestinal lubrication with functional Qi support for bowel movement.

When to use: Constipation from intestinal dryness, especially in elderly or postpartum patients who need gentle, non-purging relief.

Key Formulas

These well-known formulas feature Zi Su Zi in a prominent role

Su Zi Jiang Qi Tang 蘇子降氣湯 King

The definitive formula showcasing Zi Su Zi's core properties. From the Tai Ping Hui Min He Ji Ju Fang, this formula treats the classic 'upper excess with lower deficiency' asthma pattern. Zi Su Zi serves as King herb, powerfully descending rebellious Lung Qi, dissolving cold phlegm, and calming wheezing. The formula perfectly illustrates how Zi Su Zi's descending action addresses the upper phlegm obstruction while complementary herbs like Rou Gui warm the Kidneys below.

San Zi Yang Qin Tang 三子養親湯 King

From Han Shi Yi Tong, this elegant three-herb formula pairs Zi Su Zi with Bai Jie Zi and Lai Fu Zi to treat elderly patients with phlegm-congested cough, wheezing, and food stagnation. Zi Su Zi is typically designated King when wheezing predominates. The formula highlights how Zi Su Zi works synergistically with other seed herbs, each contributing a distinct angle on phlegm resolution.

Ding Chuan Tang 定喘湯 Assistant

From She Sheng Zhong Miao Fang, this formula treats wind-cold exterior constraint with interior phlegm-heat. Zi Su Zi plays an assistant role alongside Ban Xia and Kuan Dong Hua, supporting the main herbs in directing Qi downward, dissolving phlegm, and arresting wheezing. This formula illustrates Zi Su Zi's versatility in both pure cold-phlegm and mixed cold-heat presentations.

Comparable Ingredients

These ingredients have overlapping uses — here's how to tell them apart

Lai Fu Zi
Zi Su Zi vs Lai Fu Zi

Both Zi Su Zi and Lai Fu Zi descend Qi and resolve phlegm to relieve cough and wheezing. However, Zi Su Zi's primary strength is descending Lung Qi and calming wheezing, while Lai Fu Zi's primary strength is dissolving food stagnation and promoting digestion. A classical summary states: Zi Su Zi 'descends Lung Qi to resolve phlegm,' while Lai Fu Zi 'breaks down food accumulation to move Qi.' When wheezing is the main symptom, Zi Su Zi takes the lead; when food stagnation and bloating dominate, Lai Fu Zi takes priority.

Xing Ren
Zi Su Zi vs Xing Ren

Both descend Lung Qi to relieve cough and wheezing, and both moisten the intestines. However, Xing Ren (apricot kernel) is slightly warm to neutral and is better for dry cough with little phlegm, as it has a milder moistening action on the Lungs themselves. Zi Su Zi is better for phlegm-predominant cough with copious sputum, where its stronger phlegm-dissolving and Qi-descending action is needed. Xing Ren is more versatile across hot and cold patterns, while Zi Su Zi is specifically suited for cold-phlegm patterns.

Bai Jie Zi
Zi Su Zi vs Bai Jie Zi

Both are warm and acrid, and both resolve cold phlegm. However, Bai Jie Zi (white mustard seed) specializes in expelling phlegm from deep, hard-to-reach areas (the 'skin-membrane' layer) and has a stronger dissipating action, while Zi Su Zi focuses on descending Qi in the Lungs and calming wheezing. Zi Su Zi also moistens the intestines due to its oil content, while Bai Jie Zi is more drying and dispersing. For phlegm stuck in the chest and flanks, Bai Jie Zi is preferred; for wheezing with rebellious Lung Qi, Zi Su Zi is preferred.

Common Substitutes & Adulterants

Related species and common adulterations to be aware of when sourcing Zi Su Zi

The most common substitution is Bai Su Zi (白苏子), the seed of the white-leaved Perilla variety (Perilla frutescens var. frutescens). White Perilla seed is larger, greyish-white in color, and has a milder aroma and weaker therapeutic effect compared to the authentic dark Zi Su Zi, which is smaller, yellowish-black, and strongly aromatic. Classical texts note: "Su Zi is yellow-black with small grains and strong, thick fragrance; Bai Su Zi is grey-white with larger grains and thin, weak fragrance; its effect is similar but weaker." To distinguish them, check for the characteristic dark grey-brown color, small size, prominent reticulate surface pattern, and strong aromatic oil when crushed. Wild Perilla seed (Perilla frutescens var. purpurascens) may also be mixed in; it is slightly smaller (0.6 to 1.5 mm) and the outer layer tends to peel away more easily, revealing a pale yellow stone cell layer underneath.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herb.

Toxicity Classification

Classical Chinese pharmacopoeia toxicity rating for Zi Su Zi

Non-toxic

Zi Su Zi is classified as non-toxic in both the Chinese Pharmacopoeia and classical sources (the Yao Xing Lun states "wu du" / 无毒). The seeds are a recognized food-grade substance in China with a long history of safe culinary use. No toxic components have been identified in normal human dosage ranges. One animal study noted that feeding large quantities of raw Perilla seed (2.3 to 15.5 g/kg) to cattle could cause atypical interstitial pneumonia, but this toxicity was not observed after frost and is not relevant to human medicinal use at standard doses.

Contraindications

Situations where Zi Su Zi should not be used or requires extra caution

Caution

Qi deficiency with chronic cough (气虚久嗽). Zi Su Zi's dispersing and descending nature can further deplete Qi in already weakened individuals, worsening the cough rather than resolving it.

Caution

Yin deficiency with wheezing or dry cough (阴虚喘逆). The warm, acrid nature of this herb can further damage Yin fluids and worsen dryness symptoms such as dry throat, scanty sticky phlegm, or night sweats.

Caution

Spleen deficiency with loose stools or diarrhea (脾虚便滑/便溏). Because Zi Su Zi is rich in oil and has a moistening, intestine-lubricating effect, it can aggravate loose stools in people with weak digestion.

Avoid

Known allergy or hypersensitivity to Perilla frutescens. Though uncommon, allergic reactions including skin rash, itching, nausea, or vomiting have been reported.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe at standard doses for short-term use during pregnancy. The sister herb Zi Su Ye (Perilla leaf) and Zi Su Geng (Perilla stem) are actually used in classical formulas to calm the fetus and treat pregnancy-related nausea. However, because Zi Su Zi has a descending, Qi-moving action and lubricates the intestines, caution is warranted in pregnancy, particularly in cases with a history of threatened miscarriage or those with weak Spleen Qi and loose stools. Use under practitioner guidance.

Breastfeeding

No specific contraindications have been documented for breastfeeding. Perilla seed is a recognized food-grade substance with a long history of culinary use across East Asia, and its main active components (unsaturated fatty acids like alpha-linolenic acid) are common in human nutrition. Standard medicinal doses are unlikely to pose a risk to the nursing infant. However, because formal safety studies in breastfeeding women are lacking, it is prudent to use under practitioner guidance.

Children

Zi Su Zi has been used for children in classical formulas. The Su Zi San from the Dian Nan Ben Cao specifically recommends a dose of about one qian (approximately 3g) for children with chronic cough and phlegm, compared to three qian for adults. For modern pediatric use, reduce dosage proportionally based on age and body weight, typically one-third to one-half of the adult dose. Because the seeds are oily and can loosen stools, monitor bowel function in children, especially those with weak digestion. Use under practitioner supervision.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Zi Su Zi

No well-documented pharmaceutical drug interactions specific to Zi Su Zi have been established in clinical literature. However, based on the pharmacological properties of its major active compounds, the following theoretical considerations apply:

  • Anticoagulant/antiplatelet medications: Perilla seed oil is very rich in alpha-linolenic acid (an omega-3 fatty acid), which at high doses may have mild blood-thinning effects. Concurrent use with warfarin, heparin, or antiplatelet drugs could theoretically increase bleeding risk, though this has not been confirmed clinically at standard herbal doses.
  • Hypoglycemic medications: Some sources suggest Perilla may have mild blood sugar-lowering effects. Diabetic patients on insulin or oral hypoglycemic agents should monitor blood glucose levels if taking Zi Su Zi regularly.
  • Antihypertensive medications: Perilla seed oil has shown mild blood pressure-lowering activity in some research. Additive effects with antihypertensive drugs are theoretically possible.

These interactions are theoretical rather than clinically confirmed at standard decoction doses. Patients on any of these medications should inform their healthcare providers.

Dietary Advice

Foods and dietary considerations when taking Zi Su Zi

Avoid excessive cold, raw foods while taking Zi Su Zi for cough and phlegm conditions, as cold foods can increase phlegm production and counteract the herb's warming, phlegm-resolving action. Greasy, rich foods should also be moderated, as they contribute to phlegm dampness. Fish and crab are traditionally considered compatible with Perilla (the whole plant is classically used to detoxify fish and crab), so no special avoidance is needed. Warm soups and congees complement this herb's action well.

Botanical Description

Physical characteristics and morphology of the Zi Su Zi source plant

Perilla frutescens (L.) Britt. is an annual herbaceous plant in the Lamiaceae (mint) family, growing 60 to 150 cm tall. The stems are erect, square-shaped, hairy, and often purple-tinged, with many branches. The leaves are opposite, broadly ovate with pointed tips and serrated margins, measuring 7 to 12 cm long and 5 to 8 cm wide. In the purple-leaved variety used medicinally, both leaf surfaces are deep purple or the upper surface is green with the underside purple. The small tubular flowers are pale purple to pink, appearing in late summer on terminal and axillary racemes. The fruit is a small nutlet (the medicinal part, Zi Su Zi), ovoid to spherical, approximately 0.6 to 2 mm in diameter, with a grey-brown to dark brown surface bearing a raised reticulate (net-like) pattern.

The plant thrives in warm, humid climates with full sun and prefers moist, loose, fertile soils, though it adapts to a wide range of soil types. It is native to East and Southeast Asia, growing wild along roadsides, field margins, and in waste ground, and is widely cultivated across China, Japan, and Korea.

Sourcing & Harvesting

Where Zi Su Zi is sourced, when it's harvested or collected, and how to assess quality

Harvesting season

Autumn (September to October), when the fruits are fully mature and the plant begins to dry. The entire plant or fruit clusters are cut, the fruits are threshed out, cleaned of impurities, and sun-dried.

Primary growing regions

Widely cultivated throughout China. Major producing regions include Hubei (the largest producer), Jiangsu, Henan, Shandong, Jiangxi, Zhejiang, Sichuan, Anhui, and Hebei provinces. Wild Perilla also grows in Guangdong, Guangxi, Shanxi, and parts of southwestern China. There is no single strongly defined dao di (terroir) region, but Hubei province is traditionally recognized as producing the largest quantity of high-quality Zi Su Zi.

Quality indicators

Good quality Zi Su Zi seeds are plump, uniformly sized, and grey-brown in color with a clearly visible raised net-like (reticulate) pattern on the surface. When crushed, the seeds should release a distinctly aromatic, slightly pungent fragrance and reveal yellowish-white, oily seed kernels inside. The fruit skin should be thin, crisp, and easily cracked. Seeds that are shriveled, dark black, musty-smelling, or lacking in oil content are inferior. The best quality seeds are described classically as: large, full grains, grey-brown color, rich in oil (以粒大饱满、色灰棕、油性足者为佳).

Classical Texts

Key passages from the classical Chinese medical texts that describe Zi Su Zi and its therapeutic uses

Ming Yi Bie Lu (名医别录)

Original: 味辛,温。主下气,除寒中。其子尤良。

Translation: Acrid in flavor, warm in nature. Governs directing Qi downward and dispelling Cold from the Middle Burner. The seeds are especially effective.

Ben Cao Gang Mu (本草纲目) — Li Shizhen

Original: 苏子与叶同功,发散风气宜用叶,清利上下则宜用子也。

Translation: The seeds and leaves of Perilla share similar functions. For dispersing wind, the leaves are preferred; for clearing and regulating Qi throughout the upper and lower body, the seeds are preferred.

Ben Cao Shu (本草述) — Liu Ruojin

Original: 每言苏子下气之功胜于叶者。盖叶、茎、子俱能和气,但叶则和而散,茎则和而通,子乃和而降,用者其细审之。

Translation: It is often said that the seed's ability to direct Qi downward surpasses that of the leaf. The leaf, stem, and seed can all harmonize Qi, but the leaf harmonizes and disperses, the stem harmonizes and unblocks, while the seed harmonizes and descends. Practitioners should carefully distinguish these differences.

Ben Cao Feng Yuan (本草逢原)

Original: 诸香皆燥,惟苏子独润,为虚劳咳嗽之专药。

Translation: Among all aromatic herbs, most are drying, yet Perilla seed alone is moistening. It is therefore a specialized remedy for cough due to consumptive deficiency.

Yao Pin Hua Yi (药品化义)

Original: 苏子主降,味辛气香主散,降而且散,故专利郁痰。

Translation: Perilla seed primarily descends. Its acrid taste and aromatic Qi promote dispersal. By descending and dispersing, it especially frees up stagnant phlegm.

Historical Context

The history and evolution of Zi Su Zi's use in Chinese medicine over the centuries

Perilla has been used as both food and medicine in China for over two thousand years. The earliest medicinal distinction of the seed from the leaf appears in the Ming Yi Bie Lu (名医别录) of the Southern and Northern Dynasties period, which noted that "the seeds are especially effective" (其子尤良) for directing Qi downward. Before this, the whole plant was used collectively. The name 紫苏 (Zi Su) literally means "purple revival" or "purple resuscitation," traditionally explained by the plant's striking purple color and its ability to revive and restore proper Qi circulation.

Li Shizhen's Ben Cao Gang Mu (16th century) provided the clearest differentiation of the three medicinal parts: the leaf (Su Ye) for exterior-releasing, the stem (Su Geng) for Qi regulation, and the seed (Su Zi) for descending Qi and clearing phlegm. This functional distinction remains the basis of clinical practice today. The famous formula San Zi Yang Qin Tang (Three-Seed Filial Devotion Decoction) from the Han Shi Yi Tong (韩氏医通) by Han Mao pairs Zi Su Zi with Bai Jie Zi and Lai Fu Zi. The formula's poetic name reflects its origin as a gentle remedy designed for elderly parents with phlegm-related cough and wheezing. In the Su Zi Jiang Qi Tang (Perilla Seed Qi-Descending Decoction) from the Tai Ping Hui Min He Ji Ju Fang, Zi Su Zi serves as the lead herb for upper excess with lower deficiency patterns of wheezing.

Perilla seeds have also long served a culinary role across East Asia. In China, roasted seeds were traditionally ground with salt to make a condiment (苏子盐), notably used in Beijing's traditional mian cha (面茶) snack. In Korea, the seeds are pressed for cooking oil (deulkkireum), and in Japan, roasted perilla seeds are used in regional preparations. This dual food-medicine status is officially recognized in China, where Zi Su Zi is classified as a "drug-food dual-use" (药食同源) substance.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Zi Su Zi

1

Review: Applications of Perilla frutescens Extracts in Clinical Practice (2023)

Adam G, Robu S, Flutur MM, Cioanca O, Vasilache IA, Adam AM, Mircea C, Nechita A, Harabor V, Harabor A, Hancianu M. Molecules. 2023;28(6):2760.

A systematic review of all human interventional studies on Perilla frutescens. The authors found evidence for anti-allergic, anti-inflammatory, antioxidant, and lipid-lowering effects from various Perilla preparations (leaf, seed oil), though most clinical evidence remains limited and further controlled trials are needed.

PubMed
2

RCT: Perilla frutescens Seed Oil Combined with Anredera cordifolia Leaf Powder Attenuates Age-Related Cognitive Decline (2022)

Hashimoto M, Matsuzaki K, Maruyama K, Sumiyoshi E, Hossain S, Wakatsuki H, Kato S, Ohno M, Tanabe Y, Kuroda Y, Yamaguchi S, Kajima K, Ohizumi Y, Shido O. Food Funct. 2022;13(13):7226-7239.

A 12-month randomized, double-blind trial in healthy elderly Japanese individuals found that daily supplementation with alpha-linolenic acid-rich Perilla seed oil, especially when combined with Anredera cordifolia, was associated with improved cognitive scores and reduced serum triglyceride and glucose levels.

3

Preclinical: Anti-inflammatory Effect of Perilla frutescens Seed Oil on DSS-induced Colitis in Mice (2021)

Paradee N, Koonyosying P, Kusirisin W, Janthip R, Kanjanapothi D, Pattanapanyasat K, Srichairatanakool S. Biosci Rep. 2021;41(1):BSR20203166.

In a mouse model of colitis, pretreatment with cold-pressed Perilla seed oil (rich in omega-3 alpha-linolenic acid) significantly reduced clinical disease severity, histopathological damage, and levels of pro-inflammatory cytokines (IL-1 beta, IL-6, TNF-alpha) in a dose-dependent manner.

PubMed
4

Review: Comprehensive Review of Perilla frutescens: Chemical Composition, Pharmacological Mechanisms, and Industrial Applications (2025)

PMC article. PMC. 2025;PMC11988686.

A comprehensive review identifying key bioactive compounds (rosmarinic acid, luteolin, apigenin, alpha-linolenic acid) and documenting their antimicrobial, antiviral, anticancer, anti-inflammatory, antioxidant, hypoglycemic, and neuroprotective activities across various experimental models. The seed oil's omega-3 content exceeding 60% is highlighted as a major health-promoting feature.

Research on individual TCM herbs is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.