Geng Nian An 2

MenoPeace 2 (Peaceful Menopause 2) · 更年安2

Also known as: MenoPeace 2, Geng Nian An Er Hao

A modern formula designed to provide relief from frequent or intense menopausal symptoms such as hot flashes, mood swings, irritability, and insomnia. It works by nourishing the body's cooling and calming resources (Yin), settling excessive rising heat in the Liver and Heart, and calming the mind. It is intended as a symptom relief formula and is often paired with Geng Nian An 1 for long-term maintenance.

Origin Modern clinical formula designed by Dr. Ann Wang (Treasure of the East / Tianjiang Pharmaceutical) — Modern (contemporary clinical formula)
Composition 13 herbs
Shu Di huang
King
Shu Di huang
Nu Zhen Zi
Deputy
Nu Zhen Zi
Ma Bian Cao
Deputy
Ma Bian Cao
Bai Shao
Deputy
Bai Shao
Huang Qin
Assistant
Huang Qin
Gou Teng
Assistant
Gou Teng
Ju Hua
Assistant
Ju Hua
Da Huang
Assistant
Da Huang
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Geng Nian An 2 is designed to correct these specific patterns.

Why Geng Nian An 2 addresses this pattern

Kidney Yin Deficiency is the root pattern of menopause in TCM. As Kidney Yin declines, the body loses its cooling, moistening, and anchoring resources. This produces Heat signs from the unchecked relative excess of Yang. Geng Nian An 2 addresses this with Sheng Di Huang as the primary Yin tonic, supported by the Er Zhi Wan pair (Nu Zhen Zi and Han Lian Cao) and the fluid-preserving action of Wu Wei Zi. Together these herbs replenish the depleted Yin reservoir. Bai Shao further nourishes the Liver-Kidney Yin axis. Although this formula addresses the root, its strength lies in simultaneously managing the branch symptoms that arise from this deficiency.

A practitioner would look for one or more of these signs

Menopausal Hot Flashes

Waves of heat, especially in upper body and face

Night Sweats

Yin deficiency failing to contain fluids at night

Dry Mouth

Fluids depleted by deficiency Heat

Tinnitus

Kidney failing to nourish the ears

Lower Back Pain

Soreness and weakness in the lumbar region

Five Palm Heat

Heat in palms, soles, and chest

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Geng Nian An 2 when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, menopause corresponds to the natural decline of Kidney Yin and the waning of Tian Gui (the reproductive essence). As Kidney Yin diminishes, two critical relationships break down. First, the Kidney can no longer nourish and anchor the Liver, so Liver Yang rises unchecked, producing hot flashes, headaches, irritability, and dizziness. Second, Kidney Water can no longer ascend to cool and communicate with the Heart, causing Heart Fire to flare upward, which manifests as insomnia, palpitations, restlessness, and anxiety. The result is an upper body dominated by Heat and agitation, while the lower body shows signs of depletion like low back soreness and weakened knees.

Why Geng Nian An 2 Helps

Geng Nian An 2 addresses all three layers of this menopausal pathology simultaneously, which is what makes it suitable for acute or severe presentations. Sheng Di Huang, Nu Zhen Zi, Han Lian Cao, and Bai Shao replenish the depleted Kidney and Liver Yin at the root level. Gou Teng, Ju Hua, and Long Chi subdue the rising Liver Yang responsible for hot flashes, headaches, and emotional volatility. Huang Qin and Da Huang clear and drain Heat that has accumulated in the upper and middle body. Suan Zao Ren, He Huan Pi, and Long Chi calm the Heart spirit to restore sleep and emotional stability. Wu Wei Zi prevents further fluid loss from sweating. This multi-target approach provides faster symptom relief compared to purely Yin-tonifying formulas.

Also commonly used for

Mood Swings

Emotional volatility during menopause

Night Sweats

Nocturnal sweating from Yin deficiency

Anxiety

Restlessness and nervousness during menopause

Hypertension

Blood pressure instability associated with Liver Yang rising pattern

Palpitations

Heart palpitations from Heart-Kidney disharmony

Premature Ovarian Insufficiency

Early decline of ovarian function with Yin deficiency signs

What This Formula Does

Every TCM formula has a specific set of actions — here's what Geng Nian An 2 does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Geng Nian An 2 is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Geng Nian An 2 performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Geng Nian An 2 works at the root level.

In TCM, menopause is understood as a natural life transition rooted in the decline of Kidney Essence (Jing). As described in the Huang Di Nei Jing, around age 49 a woman's Tian Gui (reproductive essence) becomes exhausted, and the Chong and Ren vessels weaken. This fundamental Kidney Yin depletion sets off a cascade of imbalances across multiple organ systems.

Geng Nian An 2 specifically addresses the pattern where this Kidney Yin decline has progressed to cause two additional, more acute problems. First, when Kidney Water can no longer nourish and anchor the Liver (known as 'Water failing to nourish Wood'), Liver Yang flares upward unchecked, producing headaches, dizziness, irritability, sudden anger, and emotional volatility. Second, when Kidney Yin is insufficient, the Heart-Kidney axis breaks down: Kidney Water cannot ascend to cool Heart Fire, and Heart Fire cannot descend to warm the Kidneys. This failure of Heart-Kidney communication (心肾不交) leaves Heart Fire blazing upward, causing insomnia, palpitations, anxiety, mental restlessness, and the characteristic sensation of heat rising to the face and chest.

The Empty Heat generated by Yin deficiency also forces fluids outward, producing hot flashes and night sweats. The formula's disease logic therefore involves three interlocking layers: Kidney Yin deficiency as the root, Liver Yang rising as a branch manifestation, and Heart Fire flaring as an additional branch. Unlike Geng Nian An 1, which focuses primarily on replenishing Kidney Yin for maintenance, Geng Nian An 2 places greater emphasis on controlling these acute Liver and Heart manifestations while still addressing the underlying Kidney deficiency.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly sweet and salty with bitter undertones. Sweet to nourish Yin and Blood, salty to soften and anchor rising Yang, bitter to clear Empty Heat and calm the Mind.

Channels Entered

Ingredients

13 herbs

The herbs that make up Geng Nian An 2, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 12 - 15g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Geng Nian An 2

Nourishes Kidney Yin, clears deficiency Heat, cools the Blood, and generates fluids. As the primary Yin-nourishing herb, it addresses the root deficiency of Kidney Yin that underlies menopausal symptoms.
Deputies — Assists and enhances the King
Nu Zhen Zi

Nu Zhen Zi

Glossy privet fruits

Dosage 9 - 15g
Temperature Neutral
Taste Bitter, Sweet
Organ Affinity Kidneys, Liver

Role in Geng Nian An 2

Tonifies Liver and Kidney Yin, clears deficiency Heat, and brightens the eyes. Reinforces the King herb's Yin-nourishing action and specifically supports the Liver-Kidney axis.
Ma Bian Cao

Ma Bian Cao

Verbena leaves

Dosage 9 - 15g
Temperature Cool
Taste Bitter
Organ Affinity Spleen, Liver

Role in Geng Nian An 2

Nourishes Liver and Kidney Yin and cools the Blood. Together with Nu Zhen Zi it forms the classical Er Zhi Wan pairing, powerfully supplementing Yin from below.
Bai Shao

Bai Shao

White peony roots

Dosage 9 - 15g
Temperature Neutral
Taste Bitter, Sour
Organ Affinity Liver, Spleen

Role in Geng Nian An 2

Nourishes Blood, softens and calms the Liver, alleviates pain, and preserves Yin. Addresses Liver Yang rising by anchoring the Liver with its sour, astringent nature.
Assistants — Supports or moderates other herbs
Huang Qin

Huang Qin

Baikal skullcap roots

Dosage 6 - 12g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Large Intestine, Lungs, Small Intestine, Spleen

Role in Geng Nian An 2

Clears Heat, particularly from the upper body and Liver-Gallbladder. Wine processing directs it upward and softens its cold nature. Addresses the Heat symptoms of hot flashes, irritability, and flushed face.
Gou Teng

Gou Teng

Gambir stems and thorns

Dosage 9 - 15g
Temperature Cool
Taste Sweet
Organ Affinity Liver, Pericardium
Preparation Added in the last 5 minutes of decoction (后下) to preserve active alkaloids, when used in decoction form

Role in Geng Nian An 2

Extinguishes Liver Wind and subdues Liver Yang rising. Addresses dizziness, headache, and the agitation that comes from uncontrolled ascending Yang.
Ju Hua

Ju Hua

Chrysanthemum flowers

Dosage 9 - 12g
Temperature Cool
Taste Bitter, Sweet
Organ Affinity Liver, Lungs

Role in Geng Nian An 2

Clears Liver Heat, calms Liver Yang, and brightens the eyes. Works synergistically with Gou Teng to subdue rising Yang and address headache and dizziness.
Da Huang

Da Huang

Rhubarb

Dosage 3 - 6g
Temperature Cold
Taste Bitter
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium

Role in Geng Nian An 2

Drains Heat downward and unblocks the bowels. Used in small dosage to purge accumulated Heat from the interior, break stagnation, and direct pathogenic Heat downward and out of the body.
Suan Zao Ren

Suan Zao Ren

Jujube seeds

Dosage 9 - 15g
Temperature Neutral
Taste Sour, Sweet
Organ Affinity Gallbladder, Heart, Liver

Role in Geng Nian An 2

Nourishes Heart Blood and Liver Yin, calms the spirit, and treats insomnia. Directly addresses the sleep disturbance and restlessness that are hallmarks of menopausal Heart and Liver imbalance.
He Huan Pi

He Huan Pi

Silktree albizia barks

Dosage 9 - 15g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Liver

Role in Geng Nian An 2

Calms the spirit, relieves emotional constraint, and promotes joy. Specifically addresses irritability, anxiety, depression, and mood swings by soothing the Liver and settling the Heart.
Long Chi

Long Chi

Dragon tooth

Dosage 15 - 30g
Temperature Cool
Taste Sweet
Organ Affinity Heart, Liver
Preparation Decocted first for 20-30 minutes (先煎)

Role in Geng Nian An 2

Heavily settles and calms the spirit, anchors floating Yang. Its mineral weight helps draw down pathological ascending Yang and Fire from the Heart and Liver, addressing palpitations and restlessness.
Lian Zi

Lian Zi

Lotus seeds

Dosage 9 - 15g
Temperature Neutral
Taste Sour, Sweet
Organ Affinity Heart, Kidneys, Spleen

Role in Geng Nian An 2

Tonifies the Spleen and Kidney, stabilizes essence, and calms the Heart. Supports the middle, secures the lower, and clears Heart Heat, providing a gentle stabilizing action.
Envoy — Directs the formula to its target
Wu Wei Zi

Wu Wei Zi

Schisandra berries

Dosage 3 - 6g
Temperature Warm
Taste Sour, Sweet
Organ Affinity Heart, Kidneys, Lungs

Role in Geng Nian An 2

Astringes Lung Qi, generates fluids, tonifies the Kidney, calms the Heart, and contains leaking of essence and fluids. Its sour nature helps prevent the sweating and fluid loss associated with Yin deficiency. It harmonizes the formula by binding its nourishing and calming actions together.

Why This Combination Works

How the herbs in Geng Nian An 2 complement each other

Overall strategy

Geng Nian An 2 is built around the understanding that acute menopausal symptoms arise when declining Kidney Yin fails to anchor Liver Yang, which flares upward and disturbs the Heart. The formula simultaneously nourishes Yin from the root, subdues rising Liver Yang, clears Heat, and calms the spirit to provide broad relief from the most distressing symptoms of menopause.

King herbs

Sheng Di Huang serves as the primary Yin-nourishing and Heat-clearing herb. Raw Rehmannia enters the Kidney and Heart channels, directly replenishing the depleted Yin that is the root cause of menopausal Heat signs while cooling the Blood. Its choice over Shu Di Huang (prepared Rehmannia) is deliberate, as the cooling and Heat-clearing properties of the raw form are essential for addressing the active deficiency Heat of acute symptoms.

Deputy herbs

Nu Zhen Zi and Han Lian Cao form the classical Er Zhi Wan pair, reinforcing the Kidney and Liver Yin from a complementary angle. Together they strengthen the lower source of Yin without being overly cloying. Bai Shao softens and nourishes the Liver directly, restraining the Liver Yang that tends to rise when Yin is depleted, while also nourishing Blood to support the Heart.

Assistant herbs

This formula has a large assistant tier reflecting the complexity of acute menopausal presentations. Gou Teng and Ju Hua form a Wind-subduing and Yang-settling pair that directly addresses headache, dizziness, and the rising quality of symptoms. Huang Qin (wine-processed) clears upper body Heat and addresses hot flashes and irritability. Da Huang in small dose drains accumulated Heat downward, acting as a counterbalancing force that prevents Heat from lingering in the upper body. Suan Zao Ren, He Huan Pi, and Long Chi together form a powerful spirit-calming group: Suan Zao Ren nourishes Heart Blood and treats insomnia; He Huan Pi relieves emotional constraint and mood swings; Long Chi is a heavy mineral that anchors floating Yang and settles palpitations. Lian Zi gently supports the Spleen and Kidney while clearing residual Heart Heat.

Envoy herbs

Wu Wei Zi, with its unique five-flavour profile dominated by sourness, acts as an astringent envoy. It binds the formula's nourishing actions, prevents further leaking of fluids through sweating, and harmonizes the Kidney-Heart axis by supporting both organs simultaneously.

Notable synergies

The Nu Zhen Zi and Han Lian Cao pairing (Er Zhi Wan) is a classical combination that nourishes Liver-Kidney Yin more effectively than either herb alone. The Gou Teng and Ju Hua pair subdues Liver Yang while clearing Liver Heat, providing dual coverage for ascending symptoms. Suan Zao Ren combined with Long Chi addresses insomnia from both a Blood-nourishing and a Yang-anchoring direction, making it effective for both difficulty falling asleep and restless, disturbed sleep.

How to Prepare

Traditional preparation instructions for Geng Nian An 2

Available as concentrated granules (5:1 ratio). Dissolve approximately 4.5g of granules in hot water, taken 2 to 3 times daily. Stir until fully dissolved and drink as a warm herbal tea. The dosage may be adjusted by a qualified practitioner based on the severity of symptoms and individual response.

Common Modifications

How practitioners adapt Geng Nian An 2 for specific situations

Added
Mu Dan Pi

9-12g, cools Blood and clears deficiency Heat

Di Gu Pi

9-15g, clears deficiency Heat from the Kidney and Liver

Mu Dan Pi and Di Gu Pi are classical herbs for clearing deficiency Heat without injuring Yin, providing additional cooling power when hot flashes are intense and frequent.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Geng Nian An 2 should not be used or requires extra caution

Avoid

Pregnancy. This formula contains Yin-nourishing and heavy mineral substances that are not appropriate during pregnancy.

Avoid

Acute exterior conditions such as colds or flu with fever. The formula's Yin-nourishing and heavy-settling herbs can trap a pathogen inside the body.

Avoid

Full Heat patterns (excess Heat without underlying Yin deficiency). This formula is designed for Empty Heat arising from Yin deficiency, not for robust excess Heat conditions.

Caution

Severe Kidney Yang deficiency with pronounced cold signs (cold limbs, clear copious urination, pale tongue with white wet coating). The formula's overall cooling tendency may worsen Yang deficiency.

Caution

Spleen deficiency with Dampness (loose stools, poor appetite, heavy limbs). The rich Yin-nourishing herbs such as Shu Di Huang may be difficult to digest and may generate further Dampness.

Caution

Nursing mothers and postpartum women should use with caution due to the formula's cooling and heavy-settling properties.

Caution

Patients with liver disease should consult a practitioner before use, as several herbs in the formula (notably Zhi He Shou Wu) have been associated with rare hepatotoxicity reports.

Caution

Gluten intolerance or celiac disease. The formula contains Fu Xiao Mai (light wheat grain), which contains gluten.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The formula contains heavy mineral substances such as Ci Shi (magnetite) and Zhen Zhu Mu (mother-of-pearl) that are classified as settling and heavy-descending, which are generally avoided in pregnancy. Additionally, Mu Dan Pi (moutan bark) has mild Blood-moving properties, and Xian Mao (curculigo) is a warm Kidney Yang tonic that may not be appropriate during gestation. The overall cooling and Yin-nourishing strategy of this formula is also not aligned with the needs of pregnancy, which require supporting and securing the fetus rather than clearing Heat and subduing Yang.

Breastfeeding

Use with caution during breastfeeding. The formula's cooling and heavy-settling properties may not be ideal for the postpartum and nursing period, when the body's Qi and Blood are already depleted. Several herbs, particularly Ci Shi (magnetite) and Zhen Zhu Mu (mother-of-pearl), are heavy minerals whose constituents could theoretically transfer through breast milk. Zhi He Shou Wu (processed Polygonum multiflorum) has been associated with rare cases of liver toxicity in adults, and its safety during lactation has not been formally established. Women who are breastfeeding should consult a qualified TCM practitioner before taking this formula.

Children

Not applicable. Geng Nian An 2 is specifically formulated for perimenopausal and menopausal women and is not intended for pediatric use. Its therapeutic strategy of nourishing Kidney Yin, subduing Liver Yang, and clearing Heart Fire addresses an age-related hormonal transition that does not occur in children. There are no established pediatric dosing guidelines for this formula.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Geng Nian An 2

Antihypertensive medications: Geng Nian An 2 contains herbs that subdue Liver Yang and have potential blood pressure-lowering effects (notably Gou Teng/Uncaria and Zhen Zhu Mu/mother-of-pearl). Concurrent use with antihypertensive drugs may have an additive hypotensive effect, potentially causing excessive blood pressure reduction. Blood pressure should be monitored.

Anticoagulant and antiplatelet drugs: Mu Dan Pi (moutan bark) contains paeonol, which has demonstrated antiplatelet activity in pharmacological studies. Patients taking warfarin, heparin, aspirin, or other blood thinners should use this formula with caution, as it may enhance bleeding risk.

Sedative and anxiolytic medications: The heavy mineral substances Ci Shi (magnetite) and Zhen Zhu Mu (mother-of-pearl), along with the calming herb Shou Wu Teng (Caulis Polygoni Multiflori), have sedative properties. Combined use with benzodiazepines, sleep aids, or other CNS depressants may produce additive sedation.

Hepatotoxic medications: Zhi He Shou Wu (processed Polygonum multiflorum) has been associated with rare idiosyncratic hepatotoxicity. Caution is advised when combining with other potentially hepatotoxic drugs such as acetaminophen (paracetamol), statins, or methotrexate. Liver function monitoring may be warranted.

Hormone replacement therapy (HRT): While many women use this formula as an alternative to HRT, concurrent use with estrogen or progesterone supplements should be monitored by a healthcare provider, as the formula's phytoestrogenic herbs may interact with exogenous hormones.

Usage Guidance

Practical advice for getting the most out of Geng Nian An 2

Best time to take

Twice to three times daily, ideally 30 minutes to 1 hour before or after meals. If insomnia is a prominent symptom, taking one dose in the late afternoon and another before bed may be beneficial.

Typical duration

Used during the acute symptomatic phase of menopause, typically 4 to 8 weeks. Once symptoms stabilize, practitioners often transition to the maintenance formula Geng Nian An 1 for long-term support. Reassessment by a practitioner is recommended every 2 to 4 weeks.

Dietary advice

Avoid spicy, hot, and pungent foods (chili, raw garlic, strong alcohol, deep-fried foods) that can aggravate Heat and Liver Yang rising. Reduce greasy, rich foods that may hinder digestion and impede the absorption of the Yin-nourishing herbs. Favor cooling, Yin-nourishing foods such as pear, lily bulb, black sesame, mulberry, tremella mushroom (snow fungus), lotus seed, mung bean, cucumber, and chrysanthemum tea. During active hot flash episodes, avoid coffee and strong tea, which can worsen restlessness and insomnia. Light, easily digestible meals support the Spleen's role in transforming and transporting the formula's rich Yin-tonifying ingredients.

Geng Nian An 2 originates from Modern clinical formula designed by Dr. Ann Wang (Treasure of the East / Tianjiang Pharmaceutical) Modern (contemporary clinical formula)

Classical Texts

Key passages from the classical Chinese medical texts that first described Geng Nian An 2 and its clinical use

While Geng Nian An 2 is a modern formula and does not have direct classical source quotes, its theoretical foundation rests on principles articulated in the classical literature about women's aging and menopausal transition:

《素问·上古天真论》Su Wen, 'Discourse on the True from High Antiquity':
「女子七七,任脉虚,太冲脉衰少,天癸竭,地道不通,故形坏而无子也。」
"When a woman reaches seven times seven [age 49], the Ren Mai becomes deficient, the Chong Mai declines, Tian Gui (the reproductive essence) is exhausted, the Earth pathway is no longer open, and thus the body deteriorates and she can no longer conceive."

This passage establishes the TCM understanding that menopause results from the natural decline of Kidney Essence, which in turn depletes the Chong and Ren vessels. This Kidney Yin deficiency is the root mechanism that Geng Nian An 2 addresses.

《灵枢·天年》Ling Shu, 'Natural Lifespan':
「五十岁,肝气始衰,肝叶始薄,胆汁始灭,目始不明。」
"At fifty years of age, the Liver Qi begins to decline, the Liver lobes begin to thin, bile diminishes, and the eyes begin to lose their clarity."

This passage highlights that around the menopausal years, Liver function also declines. When Kidney Yin can no longer nourish and anchor the Liver (a concept known as 'Water failing to nourish Wood'), Liver Yang rises unchecked, producing the irritability, headaches, and dizziness that Geng Nian An 2 specifically targets.

Historical Context

How Geng Nian An 2 evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Geng Nian An 2 (更年安 2, MenoPeace 2) is a modern formula, not a classical prescription. It was designed by Dr. Ann Wang, a TCM practitioner and acupuncturist based in New York State, who was formerly a faculty member at Chin's Academy of Chinese Medical Sciences. The formula is produced by Tianjiang Pharmaceutical as part of the Treasure of the East product line and was developed based on clinical efficacy observed in TCM hospitals.

Geng Nian An 2 is a modification of Geng Nian An 1 (the standard Geng Nian An Pian formula, itself a modern Chinese patent medicine). Geng Nian An 1 focuses primarily on Kidney Yin tonification as a maintenance formula, while Geng Nian An 2 was created to provide more targeted, acute symptom relief by placing greater emphasis on calming the Liver and clearing Heart Fire. The relationship between the two formulas is sequential in clinical practice: Geng Nian An 2 is used during the active symptomatic phase, and once symptoms stabilize, patients are transitioned to Geng Nian An 1 for long-term maintenance.

The theoretical roots of both formulas draw upon classical foundations including Liu Wei Di Huang Wan (for Kidney Yin nourishment) and the Er Xian Tang principle (acknowledging that menopause involves decline of both Kidney Yin and Yang). The integration of heavy mineral substances like Ci Shi and Zhen Zhu Mu for anchoring floating Yang reflects the Tian Ma Gou Teng Yin strategy for Liver Yang rising. This modern formula thus represents a synthesis of several classical treatment strategies adapted for the specific needs of perimenopausal women.