Geng Nian An Yi

Peaceful Menopause Formula No. 1 · 更年安一

Also known as: MenoPeace 1, Geng Nian An 1, Rehmannia & Fleece-Flower Combination

A modern formula designed to support women through menopause by nourishing the Kidneys and calming the mind. It addresses common menopausal complaints such as hot flashes, night sweats, mood swings, dizziness, and sleep difficulties that arise when the body's cooling and moistening resources decline with age. It is considered a maintenance formula for long-term balance rather than acute symptom relief.

Origin Modern formula developed for TCM hospital use (现代经验方), based on classical principles of Kidney Yin nourishment and Liver Yang pacification, produced by Tianjiang Pharmaceutical — Modern, contemporary formula (20th century)
Composition 16 herbs
Shu Di huang
King
Shu Di huang
Shu Di huang
King
Shu Di huang
He Shou Wu
Deputy
He Shou Wu
Shan Zhu Yu
Deputy
Shan Zhu Yu
Xuan Shen
Deputy
Xuan Shen
Mai Dong
Deputy
Mai Dong
Xian Mao
Assistant
Xian Mao
Mu Dan Pi
Assistant
Mu Dan Pi
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Geng Nian An Yi is designed to correct these specific patterns.

Why Geng Nian An Yi addresses this pattern

Kidney Yin deficiency is the fundamental pattern in menopausal transition. As Kidney Essence and Yin naturally decline with age, the body loses its cooling, moistening, and anchoring resources. This leads to Empty Heat signs such as hot flashes, night sweats, and five-palm heat, along with dizziness, tinnitus, and lower back soreness. Geng Nian An 1 addresses this directly through its core Yin-nourishing herbs: Shu Di Huang fills Kidney Essence and Blood, Sheng Di Huang clears Empty Heat while nourishing Yin, and Xuan Shen enriches Kidney Yin and clears floating Fire. He Shou Wu reinforces Liver-Kidney Yin and Essence, while Shan Yu Rou astringes to prevent Essence leakage. The draining trio of Mu Dan Pi, Ze Xie, and Fu Ling ensures the heavy tonifying herbs are properly absorbed without creating stagnation.

A practitioner would look for one or more of these signs

Menopausal Hot Flashes

Waves of heat rising to the face and upper body

Night Sweats

Sweating during sleep, waking with damp bedclothes

Dizziness

Lightheadedness, especially on standing

Tinnitus

Ringing in the ears

Insomnia

Difficulty falling or staying asleep

Lower Back Pain

Soreness and weakness of the lower back and knees

Dry Mouth

Dry mouth and throat, especially at night

Five Center Heat

Heat in the palms, soles, and chest

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Geng Nian An Yi when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Kidney Yin Deficiency Liver Yang Rising Heart and Kidneys not harmonized

TCM Interpretation

TCM views menopause as a natural transition driven by the gradual decline of Kidney Essence and the waning of what classical texts call Tian Gui, the substance that governs reproductive capacity. As Kidney Yin becomes insufficient, the body loses its cooling, moistening, and anchoring functions. This creates a cascade: Empty Heat flares upward causing hot flashes and sweating, Liver Yang rises unchecked causing headaches and emotional volatility, and the Heart-Kidney axis loses its balance causing insomnia and palpitations. The Kidneys, Liver, and Heart are the three organ systems most centrally involved. The pattern is predominantly one of deficiency (Kidney Yin and Essence depletion) with secondary excess manifestations (Liver Yang rising, Empty Heat flaring).

Why Geng Nian An Yi Helps

Geng Nian An 1 is specifically constructed as a maintenance formula for menopausal support. Its core strategy of deeply nourishing Kidney Yin (Shu Di Huang, Sheng Di Huang, He Shou Wu, Shan Yu Rou, Xuan Shen) addresses the root cause. The inclusion of Xian Mao acknowledges that Kidney Yang also declines during menopause and prevents the formula from being one-sidedly cold. The formula simultaneously manages the three main symptom clusters: hot flashes and sweating (Sheng Di Huang, Xuan Shen, Wu Wei Zi, Fu Xiao Mai), emotional instability and headaches (Zhen Zhu Mu, Ci Shi, Gou Teng), and sleep disturbance with palpitations (Mai Men Dong, Shou Wu Teng, Fu Ling). This multi-layered approach makes it well-suited for the complex presentation of menopausal syndrome.

Also commonly used for

Night Sweats

Night sweating due to Yin deficiency

Anxiety

Menopausal anxiety and emotional instability

Dizziness

Dizziness and lightheadedness

Tinnitus

Ringing in the ears

Palpitations

Heart palpitations

Mood Swings

Emotional fluctuations during menopause

Spontaneous Sweat

Daytime sweating with minimal exertion

What This Formula Does

Every TCM formula has a specific set of actions — here's what Geng Nian An Yi does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Geng Nian An Yi is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Geng Nian An Yi performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Geng Nian An Yi works at the root level.

In TCM theory, menopause represents the natural depletion of Kidney Essence (Jing) and the exhaustion of Tian Gui, the substance that governs reproductive capacity. As Kidney Yin declines, it can no longer adequately nourish and cool the body. This creates a state of "deficiency Heat" where the cooling, moistening Yin is insufficient to balance the body's warming Yang. The result is upward-flaring of empty Fire, producing hot flashes, night sweats, heat in the palms and soles ("five-center heat"), dry mouth and throat, and a general feeling of internal restlessness.

When Kidney Yin is depleted, the Liver loses its nourishment because the Kidneys are the "mother" of the Liver in the generating cycle. Under-nourished Liver Yin fails to anchor Liver Yang, which then rises unchecked. This Liver Yang rising is responsible for dizziness, headaches, tinnitus, irritability, and emotional volatility. The unsettled Yang also disturbs the Heart Spirit (Shen), which depends on adequate Yin and Blood to remain calm and anchored. Disrupted Shen manifests as insomnia, anxiety, palpitations, and restless dreaming.

Geng Nian An 1 addresses this cascade at its root by replenishing Kidney Yin to restore the body's cooling and moistening capacity, while simultaneously anchoring rising Liver Yang with heavy mineral and shell substances, and including a small amount of Kidney Yang support (via Xian Mao) to reflect the reality that menopausal decline involves both Yin and Yang, not Yin alone.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly sweet and salty with mild bitter notes. Sweet to nourish Yin and Blood, salty to soften hardness and anchor Yang downward, bitter to clear deficiency Heat.

Channels Entered

Kidney Liver Heart Chong Mai (冲脉) Penetrating Vessel Ren Mai (任脉) Conception Vessel

Ingredients

16 herbs

The herbs that make up Geng Nian An Yi, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 12 - 24g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Geng Nian An Yi

The primary Kidney Yin and Blood tonic in the formula. Shu Di Huang fills Kidney Essence, nourishes Blood, and replenishes marrow, directly addressing the fundamental Kidney Yin deficiency that underlies menopausal symptoms.
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 12 - 15g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Geng Nian An Yi

Complements Shu Di Huang by clearing Empty Heat while simultaneously nourishing Yin. Its cool nature helps prevent Heat from damaging Body Fluids, addressing hot flashes and night sweats more directly than the prepared form.
Deputies — Assists and enhances the King
He Shou Wu

He Shou Wu

Fleeceflower roots

Dosage 9 - 15g
Temperature Warm
Taste Bitter, Sweet
Organ Affinity Heart, Kidneys, Liver

Role in Geng Nian An Yi

Reinforces the Liver and Kidneys, tonifies Essence and Blood. Supports the King herbs in replenishing the deep Kidney reserves that decline during menopause, while also nourishing Liver Blood to help stabilize emotions.
Shan Zhu Yu

Shan Zhu Yu

Cornelian cherries

Dosage 9 - 12g
Temperature Warm
Taste Sour
Organ Affinity Kidneys, Liver

Role in Geng Nian An Yi

Astringes and secures Kidney Essence, prevents the leakage of Yin fluids. Tonifies and stabilizes the Liver and Kidneys, helping to contain the sweating and fluid loss associated with Yin deficiency.
Xuan Shen

Xuan Shen

Ningpo figwort roots

Dosage 9 - 15g
Temperature Cold
Taste Bitter
Organ Affinity Large Intestine, Liver, Stomach

Role in Geng Nian An Yi

Enriches Kidney Yin and clears floating Empty Fire. Particularly useful for dry throat, irritability, and the sensation of heat rising upward that accompanies Yin deficiency.
Mai Dong

Mai Dong

Dwarf lilyturf roots

Dosage 9 - 12g
Temperature Cool
Taste Bitter, Sweet
Organ Affinity Heart, Lungs, Stomach

Role in Geng Nian An Yi

Nourishes Heart and Stomach Yin, clears Heart Heat. Addresses palpitations and irritability by moistening the Heart and calming the spirit, while also generating fluids to relieve dryness.
Assistants — Supports or moderates other herbs
Xian Mao

Xian Mao

Curculigo rhizomes

Dosage 6 - 9g
Temperature Hot
Taste Pungent
Organ Affinity Spleen, Kidneys, Liver

Role in Geng Nian An Yi

Tonifies Kidney Yang to prevent the formula from being excessively cold and one-sided. Reflects the Er Xian Tang principle that menopause involves decline of both Kidney Yin and Kidney Yang, ensuring the formula maintains a balanced approach to restoring Kidney function.
Mu Dan Pi

Mu Dan Pi

Mudan peony bark

Dosage 6 - 9g
Temperature Cool
Taste Bitter, Pungent
Organ Affinity Heart, Kidneys, Liver

Role in Geng Nian An Yi

Clears Heat from Yin deficiency and cools the Blood. Works alongside Ze Xie and Fu Ling (as in Liu Wei Di Huang Wan) to clear and drain, balancing the rich tonifying herbs and preventing stagnation.
Ze Xie

Ze Xie

Water plantain

Dosage 6 - 9g
Temperature Cold
Taste Sweet
Organ Affinity Urinary Bladder, Kidneys

Role in Geng Nian An Yi

Drains Kidney Fire and promotes urination to clear turbidity. Prevents the rich Yin-tonifying herbs from causing dampness or stagnation, ensuring smooth absorption of the nourishing ingredients.
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 9 - 12g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Geng Nian An Yi

Strengthens the Spleen and promotes the transformation of dampness to support the digestion of the heavy tonifying herbs. Also quiets the Heart and calms the spirit, helping with insomnia and restlessness.
Zhen Zhu Mu

Zhen Zhu Mu

Mother of pearl

Dosage 15 - 30g
Temperature Cold
Taste Salty, Sweet
Organ Affinity Heart, Liver
Preparation Decoct first for 20-30 minutes (先煎)

Role in Geng Nian An Yi

A heavy substance that subdues rising Liver Yang and benefits Liver Yin. Calms the spirit and addresses headaches, dizziness, irritability, and emotional instability caused by Liver Yang ascending due to Yin deficiency.
Ci Shi

Ci Shi

Magnetite

Dosage 15 - 30g
Temperature Cold
Taste Salty
Organ Affinity Heart, Kidneys, Liver, Lungs
Preparation Decoct first for 20-30 minutes (先煎)

Role in Geng Nian An Yi

A heavy mineral that anchors floating Yang and calms a restless mind. Particularly effective for tinnitus, dizziness, and insomnia caused by Kidney Yin failing to anchor Yang, allowing it to float upward.
Gou Teng

Gou Teng

Gambir stems and thorns

Dosage 9 - 12g
Temperature Cool
Taste Sweet
Organ Affinity Liver, Pericardium
Preparation Add in the last 5 minutes of decoction (后下)

Role in Geng Nian An Yi

Pacifies the Liver and extinguishes internal Wind that arises from Liver Yang rising. Addresses headaches, dizziness, and irritability, complementing the mineral substances in settling Liver Yang.
Sh

Shou Wu Teng / Ye Jiao Teng (Flowery Knotweed Stem)

Dosage 9 - 15g

Role in Geng Nian An Yi

Nourishes the Heart Blood and calms the spirit. Specifically indicated for insomnia and dream-disturbed sleep, providing gentle sedation while also promoting Blood circulation through the channels.
Wu Wei Zi

Wu Wei Zi

Schisandra berries

Dosage 3 - 6g
Temperature Warm
Taste Sour, Sweet
Organ Affinity Heart, Kidneys, Lungs

Role in Geng Nian An Yi

An astringent herb that reduces sweating, secures Kidney Essence, and calms the Heart spirit. Particularly effective at curbing night sweats and spontaneous sweating when combined with Xuan Shen and Fu Xiao Mai.
Envoy — Directs the formula to its target
Fu Xiao Mai

Fu Xiao Mai

Light wheats

Dosage 15 - 30g
Temperature Cool
Taste Sweet
Organ Affinity Heart

Role in Geng Nian An Yi

Nourishes the Heart, stops sweating, and clears deficiency Heat. Works synergistically with Wu Wei Zi and Xuan Shen to address the sweating component of menopausal symptoms while harmonizing the overall formula.

Why This Combination Works

How the herbs in Geng Nian An Yi complement each other

Overall strategy

Geng Nian An 1 addresses the root cause of menopausal symptoms, Kidney Yin deficiency leading to Empty Heat and Liver Yang rising, by building a strong foundation of Kidney Yin nourishment while simultaneously clearing deficiency Heat, subduing Liver Yang, and calming the spirit. It draws structural elements from Liu Wei Di Huang Wan and conceptual elements from Er Xian Tang, creating a comprehensive maintenance formula that addresses multiple layers of menopausal pathology.

King herbs

Shu Di Huang and Sheng Di Huang together form the core Yin-nourishing pair. Shu Di Huang is the primary Kidney Yin and Blood tonic that fills Essence and replenishes marrow at the deepest level. Sheng Di Huang complements this by actively clearing Empty Heat while nourishing Yin, directly cooling the hot flashes and night sweats that result from deficiency Heat. Together they address both the root (Yin depletion) and a key branch (Heat signs).

Deputy herbs

He Shou Wu (processed) reinforces Liver and Kidney function by tonifying Essence and Blood, adding depth to the Yin-nourishing strategy. Shan Yu Rou astringes and secures Kidney Essence, preventing the leakage of Yin fluids through sweating. Xuan Shen enriches Kidney Yin and clears floating Empty Fire, targeting the rising Heat sensations. Mai Men Dong nourishes Heart and Stomach Yin, directly calming Heart Heat responsible for palpitations and irritability.

Assistant herbs

Xian Mao (reinforcing) provides a small amount of Kidney Yang warmth, preventing the formula from becoming excessively cold and ensuring that the Kidney's warming function is not neglected, since menopause involves decline of both Yin and Yang. Mu Dan Pi, Ze Xie, and Fu Ling (restraining) form the draining trio from Liu Wei Di Huang Wan, preventing the heavy tonifying herbs from causing stagnation or dampness. Zhen Zhu Mu and Ci Shi (counteracting) are heavy minerals that anchor floating Yang and calm the restless spirit, addressing the secondary symptoms of dizziness, tinnitus, headaches, and insomnia. Gou Teng pacifies the Liver and extinguishes internal Wind from ascending Yang. Shou Wu Teng nourishes Heart Blood and calms the spirit specifically for insomnia. Wu Wei Zi astringes to stop sweating and secure Essence.

Envoy herbs

Fu Xiao Mai nourishes the Heart, stops sweating, and clears deficiency Heat. It harmonizes the formula by bridging the Yin-nourishing and spirit-calming functions, while working synergistically with Wu Wei Zi to control the sweating that is a hallmark menopausal complaint.

Notable synergies

Shu Di Huang and Sheng Di Huang together provide both deep Yin nourishment and active Heat-clearing, a more comprehensive approach than either alone. The pairing of Wu Wei Zi, Xuan Shen, and Fu Xiao Mai forms a potent anti-sweating trio effective for both day and night sweating. Zhen Zhu Mu and Ci Shi together create a powerful anchoring effect on floating Yang, addressing dizziness, tinnitus, and mental restlessness more effectively than either mineral alone. Xian Mao's small Yang-tonifying contribution balances the predominantly Yin-nourishing formula, echoing the Er Xian Tang principle that menopausal treatment should not neglect Yang.

How to Prepare

Traditional preparation instructions for Geng Nian An Yi

As a concentrated 5:1 granule extract: mix 4.5 g of granules in hot water and drink as a tea, 2 to 3 times daily. If using the capsule form, take 4 capsules, 2 to 3 times daily. The daily total of approximately 9 g of granules is equivalent to roughly 45 g of raw herbs.

If preparing as a traditional decoction from raw herbs, combine the herbs in their indicated proportions. Add approximately 600-800 mL of water. Bring to a boil, then simmer on low heat for 30 to 40 minutes. Strain and divide the resulting liquid into two portions, taken warm in the morning and evening. Mineral substances (Zhen Zhu Mu, Ci Shi) should be decocted first for 20 to 30 minutes before adding the remaining herbs.

Common Modifications

How practitioners adapt Geng Nian An Yi for specific situations

Added
Zhi Mu

9-12g, clears deficiency Heat and nourishes Yin

Huang Qi

6-9g, drains Kidney Fire and clears Empty Heat

Adding Zhi Mu and Huang Bai follows the Zhi Bai Di Huang Wan principle, significantly boosting the formula's ability to clear deficiency Fire when hot flashes and sweating are the dominant complaints.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Geng Nian An Yi should not be used or requires extra caution

Avoid

Pregnancy. This formula contains Xian Mao (Curculigo), which has warming, Yang-tonifying properties that may stimulate the uterus, and several heavy mineral substances (Ci Shi, Zhen Zhu Mu) whose safety in pregnancy is not established. The official drug labelling for Geng Nian An states: contraindicated in pregnancy.

Avoid

True Heat or Excess Heat patterns. This formula is designed for deficiency Heat arising from Yin depletion. It should not be used for conditions with genuine excess Heat or active exterior Wind-Heat infections, as the Yin-tonifying herbs may trap pathogenic factors.

Caution

Spleen and Stomach deficiency with significant Dampness or loose stools. The formula contains multiple rich, cloying Yin-tonifying herbs (Shu Di Huang, Sheng Di Huang, Xuan Shen, Mai Dong, Zhi He Shou Wu) that may burden a weak digestive system and worsen Dampness or diarrhea. Should be modified or combined with Spleen-strengthening herbs if used in such patients.

Caution

Kidney Yang deficiency as the predominant pattern (marked cold limbs, profuse clear urine, deep-slow pulse, pale tongue). While the formula contains a small amount of Xian Mao for mild Yang support, it is primarily a Yin-nourishing, cooling formula and may worsen pronounced Yang deficiency symptoms.

Caution

Individuals with pre-existing liver disease should use with caution, as long-term use of Zhi He Shou Wu (processed Polygonum multiflorum) has been associated with hepatotoxicity in some reports.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The official drug labelling for Geng Nian An explicitly prohibits use in pregnant women. Xian Mao (Curculigo) is a warming, Yang-tonifying herb with potential uterine-stimulating activity that poses a risk of miscarriage. Zhi He Shou Wu (processed Polygonum) also carries precautionary warnings for pregnancy. Additionally, the heavy mineral substances Ci Shi (magnetite) and Zhen Zhu Mu (mother of pearl shell) lack adequate pregnancy safety data. This formula is designed specifically for perimenopausal and postmenopausal women and has no appropriate indication during pregnancy.

Breastfeeding

Use with caution during breastfeeding. This formula is designed for perimenopausal and postmenopausal women, so breastfeeding is rarely a clinical concern. However, if used during lactation for any reason: Zhi He Shou Wu (processed Polygonum multiflorum) has potential hepatotoxicity concerns and its transfer through breast milk is not well studied. Xian Mao (Curculigo) has hormonal effects that could theoretically influence lactation. Ci Shi (magnetite) contains heavy mineral content with unknown transfer to breast milk. No formal lactation safety studies exist for this formula. Consult a qualified practitioner before use while breastfeeding.

Children

Not appropriate for pediatric use. Geng Nian An 1 is specifically designed for perimenopausal and postmenopausal women experiencing Kidney Yin deficiency with Liver Yang rising. It has no pediatric indication. The formula contains heavy mineral substances (magnetite, mother of pearl) and herbs with hormonal activity (Xian Mao) that are not suitable for children. No pediatric dosage guidelines exist for this formula.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Geng Nian An Yi

Antihypertensive medications: Gou Teng (Uncaria) and Zhen Zhu Mu (mother of pearl) have blood-pressure-lowering effects. Concurrent use with antihypertensive drugs may potentiate hypotensive effects, requiring blood pressure monitoring.

Anticoagulant and antiplatelet drugs: Xian Mao (Curculigo) has been noted to have blood-activating properties. Caution is advised when combining with warfarin, aspirin, or other anticoagulants, as this may increase bleeding risk.

Hormone replacement therapy (HRT) and oral contraceptives: Xian Mao has phytoestrogenic and hormone-like activity. Concurrent use with exogenous hormones may produce unpredictable additive effects on estrogen-sensitive tissues.

Hepatotoxic medications: Zhi He Shou Wu (processed Polygonum multiflorum) has been associated with idiosyncratic hepatotoxicity. Combining with other potentially hepatotoxic drugs (e.g. acetaminophen/paracetamol at high doses, statins, certain antibiotics) may increase liver burden. Liver function monitoring is recommended during long-term use.

Sedative and anxiolytic medications: The Spirit-calming mineral and shell ingredients (Ci Shi, Zhen Zhu Mu) combined with Shou Wu Teng (Caulis Polygoni Multiflori) may have additive sedative effects with benzodiazepines or other CNS depressants.

Usage Guidance

Practical advice for getting the most out of Geng Nian An Yi

Best time to take

Twice or three times daily, 30-60 minutes after meals to reduce digestive burden from the rich Yin-tonifying ingredients.

Typical duration

Often taken for 4-12 weeks as a maintenance formula, with periodic reassessment by a practitioner. May be used long-term with breaks as needed.

Dietary advice

Favor foods that nourish Yin and cool the body: black sesame seeds, walnuts, mulberries, goji berries, pears, lotus seeds, lily bulb (bai he), duck, and tofu. Incorporate foods that support Kidney Essence such as black beans, sea vegetables, and bone broth. Avoid or reduce spicy, hot, and drying foods (chili peppers, garlic, ginger in excess, lamb, deep-fried foods) which may aggravate deficiency Heat and worsen hot flashes. Limit alcohol and coffee, as these can disrupt sleep and intensify night sweats. Avoid cold, raw foods in excess if digestion is weak, since the formula's rich Yin-tonifying herbs already place some burden on the Spleen and Stomach.

Geng Nian An Yi originates from Modern formula developed for TCM hospital use (现代经验方), based on classical principles of Kidney Yin nourishment and Liver Yang pacification, produced by Tianjiang Pharmaceutical Modern, contemporary formula (20th century)

Classical Texts

Key passages from the classical Chinese medical texts that first described Geng Nian An Yi and its clinical use

This is a modern formula without direct classical quotations attributed to it. However, its theoretical foundation draws upon the following key classical passages:

The Huang Di Nei Jing Su Wen describes the natural decline of women's reproductive function: 「女子七七,任脉虚,太冲脉衰少,天癸竭,地道不通,故形坏而无子也。」
("At seven times seven [age 49], the Ren Mai becomes deficient, the Chong Mai declines, Tian Gui [the reproductive essence] is exhausted, the lower passage is blocked, and so the body deteriorates and she can no longer bear children.")

This passage establishes the TCM understanding of menopause as rooted in Kidney depletion and the decline of the Chong and Ren extraordinary vessels, which is precisely the pathological framework Geng Nian An 1 is designed to address.

Historical Context

How Geng Nian An Yi evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Geng Nian An (更年安, "Peaceful Menopause") is a modern Chinese formula, not a classical prescription from the historical medical literature. It was developed in contemporary China as a patent medicine (zhong cheng yao) specifically for menopausal syndrome (绝经前后诸证), and was included in the Chinese Pharmacopoeia as a standardized proprietary Chinese medicine product. It is available in tablet (片), capsule (胶囊), and pill (丸) forms from various manufacturers.

The "Geng Nian An 1" designation represents a specific formulation offered by Tianjiang Pharmaceutical (through the Treasure of the East product line) that positions this version as a maintenance formula focused on long-term Kidney Yin support, distinguishing it from "Geng Nian An 2" which is modified for more acute symptom relief with greater emphasis on clearing Liver and Heart Heat. This paired approach reflects the clinical reality that menopausal treatment often requires both acute management and long-term constitutional support.

The formula's theoretical roots draw from multiple classical traditions: the Yin-nourishing strategy of Liu Wei Di Huang Wan (from Qian Yi's pediatric tradition, later widely adopted for Kidney Yin deficiency), the Yang-supporting principle of Er Xian Tang (a modern formula itself, from Shanghai TCM hospital traditions), and the Spirit-calming approach of heavy mineral and shell substances long used in Chinese medicine for anchoring rising Yang and settling the mind.

Modern Research

A published study investigating the pharmacological effects or clinical outcomes of Geng Nian An Yi

1

Evidence-based Chinese medicine clinical practice guideline on menopausal syndrome in Hong Kong (Guideline, 2022)

Chen H et al. Journal of Traditional and Complementary Medicine, 2022

This evidence-based clinical guideline systematically assessed proprietary Chinese medicines for menopause. Geng Nian An capsule was listed among six recommended proprietary Chinese medicines for improving menopausal symptoms in a mainland China guideline, though the evidence quality for most Chinese herbal treatments for menopause was rated as low to very low.

Link

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.