Herb Rhizome (根茎 gēn jīng)

Sheng Ma

Bugbane rhizome · 升麻

Cimicifuga foetida L., Cimicifuga dahurica (Turcz.) Maxim., Cimicifuga heracleifolia Kom. · Rhizoma Cimicifugae

Also known as: Cimicifuga rhizome, Zhou Sheng Ma (周升麻), Zhou Ma (周麻),

Images shown are for educational purposes only

Shēng Má is a versatile herb used in Chinese medicine primarily for three purposes: helping skin rashes (like measles) come to the surface properly, clearing inflammatory Heat and toxins from the mouth and throat (such as gum infections and mouth sores), and supporting the body's Qi when it is sinking, which can manifest as organ prolapse or chronic diarrhea. It is a common ingredient in formulas for dental pain, sore throat, and conditions where internal organs have dropped from their normal position.

TCM Properties

Temperature

Slightly Cool

Taste

Acrid / Pungent (辛 xīn), Sweet (甘 gān)

Channels entered

Lungs, Spleen, Stomach, Large Intestine

Parts used

Rhizome (根茎 gēn jīng)

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What This Herb Does

Every herb has a specific set of actions — here's what Sheng Ma does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Sheng Ma is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Sheng Ma performs to restore balance in the body:

How these actions work

'Releases the exterior and vents rashes' means Shēng Má helps push out pathogenic factors from the body's surface layer. Its most important clinical application in this regard is not ordinary colds (its surface-releasing power is relatively mild) but rather helping measles or other eruptive skin conditions come to the surface properly. When a rash should be appearing but is stuck or incomplete, Shēng Má's light, ascending, dispersing nature helps push it outward. It is classically paired with Gě Gēn (Kudzu root) for this purpose.

'Clears Heat and resolves toxins' is considered one of Shēng Má's strongest and most distinctive actions. Because it enters the Stomach and Large Intestine channels (both part of the Yáng Míng system), it is particularly effective at clearing toxic Heat from the mouth and face. This is why it is a key herb for conditions like painful, swollen gums, mouth sores, sore throat, and facial skin infections driven by Heat toxin. It is often combined with Huáng Lián (Coptis) and Shí Gāo (Gypsum) for severe Stomach Fire manifesting as toothache and oral ulcers.

'Raises Yang and lifts sunken Qi' refers to Shēng Má's ability to direct the body's Qi upward. In TCM, certain conditions arise when the Spleen's Qi is too weak to hold organs and functions in their proper place, leading to prolapse (of the rectum, uterus, or stomach), chronic diarrhea, and a heavy, dragging sensation in the abdomen. In small doses (3 to 6g), typically honey-processed, Shēng Má acts as a lifting agent that helps restore the upward movement of clear Qi. In the famous formula Bǔ Zhōng Yì Qì Tāng, it works alongside Chái Hú to lift the Qi that the main tonic herbs (Huáng Qí, Rén Shēn) have replenished.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony. Sheng Ma is used to help correct these specific patterns.

Why Sheng Ma addresses this pattern

Shēng Má enters the Stomach channel and has a slightly cool temperature with Heat-clearing and toxin-resolving properties. This makes it highly effective against Stomach Fire, where excessive Heat accumulates in the Yáng Míng (Stomach) system and flares upward to the gums, mouth, and face. The herb's acrid taste disperses the congested Heat while its cool nature directly clears the Fire. It is considered a 'guiding herb' (引经药) for the Yáng Míng channel, directing other cooling herbs to the area where Stomach Fire manifests most visibly.

A practitioner would look for one or more of these signs

Toothache

Especially with swollen, bleeding gums from Stomach Heat

Sore

Oral ulcers with hot, foul breath

Anus Swelling

Red, swollen, eroded gums

Bad Breath

Hot, fetid mouth odour from Stomach Fire

Commonly Used For

These are conditions where Sheng Ma is frequently used — but only when they arise from the specific patterns it addresses, not in all cases

Arises from: Spleen Qi Sinking

TCM Interpretation

In TCM, rectal prolapse is understood as a failure of the Spleen's 'lifting and holding' function. The Spleen Qi is responsible for keeping organs and tissues in their proper position. When Qi becomes severely deficient through chronic illness, overwork, poor diet, or prolonged diarrhea, it can no longer support the structures of the lower body. The rectum, lacking the upward support of Qi, descends and protrudes. This is classified as a 'Qi sinking' pattern, often accompanied by fatigue, poor appetite, loose stools, and a general sense of heaviness or bearing-down in the abdomen.

Why Sheng Ma Helps

Shēng Má directly addresses the sinking tendency of Qi with its powerful upward-lifting nature. It enters the Spleen and Stomach channels, which are the very organ systems whose weakness causes the prolapse. In the classical formula Bǔ Zhōng Yì Qì Tāng, Shēng Má is used in small doses (around 3 to 6g, typically honey-processed) alongside Chái Hú to act as a 'lifting pair' that raises the Qi replenished by the formula's tonic herbs. It does not tonify Qi itself but rather redirects the newly strengthened Qi upward, restoring its holding function and encouraging the prolapsed tissue to return to its normal position.

Also commonly used for

Sore

Oral ulcers, aphthous stomatitis

Sore Throat

From Heat toxin or Wind-Heat

Chronic Diarrhea

Prolonged diarrhea from Spleen Qi collapse

Anus Swelling

Swollen, bleeding, eroded gums

Skin Rashes

Measles or eruptive rashes that fail to emerge fully

Gastroptosis

Stomach prolapse from Qi deficiency

Headaches

Wind-Heat headache or Yáng Míng channel headache

Bad Breath

Foul breath from Stomach Fire

Herb Properties

Every herb has an inherent temperature, taste, and affinity for specific channels — these properties determine how it interacts with the body

Temperature

Slightly Cool

Taste

Acrid / Pungent (辛 xīn), Sweet (甘 gān)

Channels Entered

Lungs Spleen Stomach Large Intestine

Parts Used

Rhizome (根茎 gēn jīng)

Dosage & Preparation

These are general dosage guidelines for Sheng Ma — always follow your practitioner's recommendation, as dosages vary based on the formula and your individual condition

Standard dosage

3-9g

Maximum dosage

Up to 15g when used raw (生用) for its heat-clearing and toxin-resolving function, under practitioner supervision. Some classical sources (e.g. Ben Cao Xin Bian) describe using up to 15g (五钱) in severe rash conditions with adequate supporting herbs, but this is exceptional. Do not exceed 9g for the Qi-raising indication.

Dosage notes

Sheng Ma's therapeutic effect varies significantly with dosage. At small doses (3-6g), typically honey-processed or wine-processed, it primarily raises Yang Qi and is used for organ prolapse, chronic diarrhea, and similar Qi-sinking conditions. At medium doses (6-9g), it disperses the exterior and helps push rashes outward. At larger doses (9-15g), used raw, it focuses on clearing Heat and resolving toxins for conditions like severe toothache, mouth sores, and throat swelling. This dose-dependent shift in action is an important clinical feature. For the Qi-raising function, exceeding the dose paradoxically weakens the lifting effect.

Preparation

No special decoction handling required for standard use. Sheng Ma is simply sliced and decocted normally with other herbs. However, the choice of processing form matters clinically: raw Sheng Ma (生升麻) is preferred for clearing Heat and toxins; honey-processed Sheng Ma (蜜升麻) is preferred for the gentler, more sustained Qi-raising function and is less irritating to the stomach; charred Sheng Ma (升麻炭) is used specifically for Blood-level dysentery with a mild lifting action.

Processing Methods

In TCM, the same herb can be prepared in different ways to change its effects — here's how processing alters what Sheng Ma does

Processing method

Refined honey is diluted with a small amount of boiling water, mixed with Shēng Má slices, and allowed to soak in. The mixture is then stir-fried over gentle heat until the pieces are no longer sticky to the touch. Ratio: 25 kg honey per 100 kg herb.

How it changes properties

Honey processing moderates the acrid, dispersing nature of raw Shēng Má. The sweet honey makes the lifting action gentler and more sustained while reducing irritation to the stomach. The herb's exterior-releasing and Heat-clearing actions are weakened, while the Yang-raising action becomes the dominant effect.

When to use this form

Preferred for Qi deficiency with sinking, including organ prolapse (rectal, uterine, gastric), chronic diarrhea from Spleen Qi collapse, and Qi-deficient bleeding (崩漏). This is the standard form used in tonifying and Yang-raising formulas like Bǔ Zhōng Yì Qì Tāng.

Common Herb Pairs

These ingredients are traditionally combined with Sheng Ma for enhanced therapeutic effect

Chai Hu
Chai Hu 1:1 (both typically 3-6g in tonifying formulas)

Shēng Má lifts the clear Yang of the Yáng Míng (Stomach) system on the right side, while Chái Hú lifts the clear Yang of the Shào Yáng (Liver/Gallbladder) on the left side. Together they create a bilateral lifting action that powerfully raises sunken Qi, restoring organs and functions to their proper position. This pair also mutually reinforces exterior-releasing and fever-reducing actions.

When to use: Central Qi sinking with organ prolapse (rectal, uterine, gastric), chronic diarrhea from Qi collapse, or Qi-deficient fever. Also used together to guide other herbs upward in ascending formulas.

Ge Gen
Ge Gen 1:1 (typically 9g each)

Both herbs release the muscle layer and vent rashes outward. Shēng Má excels at dispersing and detoxifying while Gě Gēn excels at generating fluids and relaxing the muscle layer. Together they form the classical combination for promoting the eruption of incomplete rashes and relieving the body surface in early-stage febrile illness.

When to use: Measles or eruptive rashes in the early stage that are slow to emerge or incomplete, with fever, headache, and thirst. Also for early-stage Wind-Heat invasion.

Huang Qi
Huang Qi Huáng Qí 15-30g : Shēng Má 3-6g (Shēng Má is used in small dose as a lifting guide)

Huáng Qí powerfully tonifies Spleen and Lung Qi, while Shēng Má lifts that newly replenished Qi upward. Huáng Qí provides the substance and Shēng Má provides the direction. Together they both replenish deficient Qi and restore its proper upward movement, addressing root and branch simultaneously.

When to use: Qi deficiency with sinking, including organ prolapse, chronic diarrhea, uterine bleeding from Qi failing to hold Blood, and general fatigue with a bearing-down sensation.

Huang Lian
Huang Lian 1:1 (typically 6g each, though ratios vary by formula)

Shēng Má clears and disperses Yáng Míng Heat toxin while guiding other herbs to the Stomach channel. Huáng Lián powerfully drains Fire and dries Dampness with its intense bitter-cold nature. Together they combine dispersing and draining actions to strongly clear Stomach Fire, particularly effective for oral and dental inflammation.

When to use: Stomach Fire causing toothache, gum swelling and erosion, mouth sores, or foul breath. The core pair within Qīng Wèi Sǎn (Clear the Stomach Powder).

Key Formulas

These well-known formulas feature Sheng Ma in a prominent role

Sheng Ma Ge Gen Tang 升麻葛根湯 King

The definitive formula showcasing Shēng Má's surface-releasing and rash-venting action. As co-King alongside Gě Gēn, Shēng Má drives the formula's ability to push incompletely erupted measles or other skin rashes to the surface. A simple four-herb formula (with Sháo Yào and Gān Cǎo) that highlights Shēng Má's dispersing and detoxifying properties.

Bu Zhong Yi Qi Tang 補中益氣湯 Assistant

The most famous formula demonstrating Shēng Má's Yang-raising action. Here it serves as the 'lifting pair' alongside Chái Hú, used in small dose (3-6g) to raise the Spleen Qi that the formula's King herb Huáng Qí and other tonics have replenished. This formula is the definitive treatment for Spleen Qi sinking with organ prolapse, chronic diarrhea, and Qi-deficient fever.

Qing Wei San 清胃散 Assistant

The key formula demonstrating Shēng Má's ability to clear Stomach Fire and resolve toxins in the mouth. Here it serves as a channel-guiding herb that directs the formula's cooling ingredients (Huáng Lián, Shēng Dì Huáng, Mǔ Dān Pí) into the Yáng Míng system while simultaneously dispersing the accumulated Heat. This formula is the standard treatment for Stomach Fire toothache with gum swelling.

Pu Ji Xiao Du Yin 普濟消毒飲 Assistant

Showcases Shēng Má's role in treating severe toxic Heat affecting the head and face. In this major Heat-clearing formula for epidemic facial swelling (大头瘟), Shēng Má helps guide the detoxifying herbs upward to the head and face while contributing its own Heat-clearing and toxin-resolving action.

Comparable Ingredients

These ingredients have overlapping uses — here's how to tell them apart

Chai Hu
Sheng Ma vs Chai Hu

Both Shēng Má and Chái Hú raise Yang and are used together for Qi sinking. However, Shēng Má lifts the Yang of the Yáng Míng (Stomach) system and also clears Heat toxins, making it the better choice when there is concurrent Stomach Fire or oral/dental inflammation. Chái Hú lifts the Yang of the Shào Yáng (Liver/Gallbladder) and also soothes Liver Qi stagnation, making it better for conditions involving emotional constraint or alternating chills and fever. Shēng Má's lifting power is considered stronger than Chái Hú's.

Ge Gen
Sheng Ma vs Ge Gen

Both Shēng Má and Gě Gēn release the muscle layer and promote rash eruption. However, Gě Gēn is primarily a Yáng Míng channel herb that generates fluids and relieves thirst and stiff neck, while Shēng Má's strength lies in its Heat-clearing and toxin-resolving action. Gě Gēn is preferred for thirst-predominant presentations and stiff upper back; Shēng Má is preferred when there is more toxic Heat in the mouth, gums, or throat. Gě Gēn can also raise Spleen Yang to stop diarrhea (especially when baked), but it lacks Shēng Má's strong organ-lifting action for prolapse.

Chan Tui
Sheng Ma vs Chan Tui

Both vent rashes and disperse Wind-Heat. Chán Tuì (cicada moulting) is lighter and cooler, better at soothing itching, clearing the voice, and benefiting the eyes. Shēng Má is stronger at clearing Heat toxins from the gums and mouth and has the additional ability to raise Yang for prolapse conditions. For rash venting, Chán Tuì is preferred when itching is prominent; Shēng Má is preferred when toxic Heat is the dominant factor preventing rash eruption.

Common Substitutes & Adulterants

Related species and common adulterations to be aware of when sourcing Sheng Ma

Sheng Ma has several common adulterants and substitutes that should be carefully distinguished: 1. Guang Dong Sheng Ma (广东升麻): Root of Serratula chinensis (Asteraceae family), used in Guangdong, Guangxi, and Fujian. This is a completely different plant family. It appears as a cylindrical or spindle-shaped root, grayish-yellow on the surface, brittle and easy to break (unlike true Sheng Ma which is hard and fibrous). It should not be used interchangeably. 2. Hong Sheng Ma (红升麻): Rhizome of Astilbe chinensis (Saxifragaceae family), used in parts of Gansu and Shaanxi. It lacks the characteristic round hollow stem-base cavities and has a white to reddish cross-section rather than yellow-green. 3. Lü Dou Sheng Ma (绿豆升麻): Rhizome of Actaea asiatica (a related Ranunculaceae species), sometimes mixed in from Sichuan and Hubei. Distinguishable by its smaller rhizome and the production of berry-like fruits (rather than follicles). 4. Fraudulent weight increase: Some commercial samples have been found adulterated with heavy stone powder to increase weight by up to 30%, which is a serious quality and safety concern.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herb.

Toxicity Classification

Classical Chinese pharmacopoeia toxicity rating for Sheng Ma

Non-toxic

Sheng Ma is classified as non-toxic at standard dosage in the Chinese Pharmacopoeia. However, its active triterpene saponins, cimigenol glycosides, and the alkaloid cimicifugine can cause adverse reactions when used in excessive amounts or when the whole plant (rather than just the rhizome) is used. Overdose symptoms include nausea, vomiting, gastrointestinal inflammation, headache, dizziness, tremor, rigid muscle spasms in the limbs, weakness, drop in blood pressure, difficulty breathing, and in severe cases delirium or respiratory paralysis. Only the dried rhizome should be used medicinally. Keeping within the standard 3-9g dosage range and avoiding prolonged unsupervised use are the primary safeguards. Proper processing (honey-roasting for the Qi-lifting function, raw use for heat-clearing) also modulates the herb's activity and reduces the risk of adverse effects.

Contraindications

Situations where Sheng Ma should not be used or requires extra caution

Avoid

Yin deficiency with floating Yang (阴虚阳浮): Sheng Ma's ascending and dispersing nature can worsen symptoms such as headache, dizziness, and feverishness in people whose condition involves deficient Yin unable to anchor Yang. This is one of the most important cautions for this herb.

Avoid

Measles that has already fully erupted (麻疹已透): Since Sheng Ma's key action is to push rashes outward, using it after the rash has already surfaced is unnecessary and can provoke excessive Heat rising, potentially causing wheezing and chest fullness.

Avoid

Wheezing and fullness with Qi rebelling upward (喘满气逆): Sheng Ma's strongly ascending nature can worsen conditions where Qi is already surging upward inappropriately, such as asthma attacks or severe bloating with rebellious Qi.

Caution

Upper excess with lower deficiency (上盛下虚): When there is excessive Heat or fullness in the upper body combined with weakness and deficiency below, Sheng Ma's upward-driving action can aggravate the imbalance.

Caution

Liver and Kidney impairment: Triterpene saponins and related compounds in Sheng Ma may pose a burden on liver and kidney function. People with pre-existing liver or kidney disease should use this herb only with careful professional guidance and reduced dosage.

Caution

Spleen and Stomach deficiency with cold: Sheng Ma is slightly cold in nature. In people whose digestive weakness stems from cold, using it without warming herbs may worsen diarrhea or poor appetite.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Sheng Ma should be used with great caution during pregnancy and is generally considered contraindicated. Its strong ascending and dispersing nature may disturb the fetus, and the triterpene saponin compounds it contains have shown potential effects on smooth muscle contraction (including uterine smooth muscle). Some sources report possible teratogenic risk. Classical texts advise against its use in pregnancy unless specifically indicated by a qualified practitioner for a defined clinical purpose at minimal effective dosage.

Breastfeeding

Safety during breastfeeding has not been well studied. Given that Sheng Ma contains bioactive triterpene saponins and alkaloids that could potentially transfer into breast milk, and given the herb's ascending and dispersing properties, it is generally recommended that breastfeeding women avoid Sheng Ma or use it only under professional guidance at minimal effective dosage for a clearly defined clinical purpose. There is insufficient data to confirm safety for the nursing infant.

Children

Sheng Ma has a long traditional history of use in pediatric formulas, particularly for helping measles rash emerge properly (as in Sheng Ma Ge Gen Tang). Dosage should be significantly reduced for children, typically to one-third to one-half of the adult dose depending on the child's age and weight. Classical pediatric sources give doses as low as 1.5g for infants. It should only be used under professional guidance, and is contraindicated once the rash has fully erupted. Given its ascending and dispersing properties, it should not be used long-term in children.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Sheng Ma

Limited formal drug interaction studies exist for Sheng Ma specifically, but the following considerations apply based on its known pharmacological properties:

  • Antihypertensive medications: Sheng Ma extracts have demonstrated blood pressure-lowering and heart rate-reducing effects in animal studies. Concurrent use with antihypertensive drugs may potentially enhance hypotensive effects.
  • Hepatotoxic drugs: Cimicifuga species have been associated with rare cases of liver injury. Concurrent use with other hepatotoxic drugs (such as acetaminophen/paracetamol at high doses, statins, or certain antibiotics) warrants caution and liver function monitoring.
  • Sedative and CNS-depressant drugs: Animal studies show Sheng Ma extracts have sedative and anticonvulsant properties. Combined use with benzodiazepines, barbiturates, or other CNS depressants could theoretically produce additive sedation.
  • Anticoagulant and antiplatelet drugs: Sheng Ma contains salicylic acid derivatives and has been described as having both anticoagulant and haemostatic properties. Patients on warfarin or similar medications should use Sheng Ma with caution.

Dietary Advice

Foods and dietary considerations when taking Sheng Ma

When using Sheng Ma for its Qi-raising function (as in Bu Zhong Yi Qi Tang), avoid cold and raw foods that could further burden the Spleen and counteract the herb's lifting action. When using it for Heat-clearing, avoid excessively spicy and greasy foods that could generate more internal Heat. The herb is slightly cold in nature, so people with cold constitutions using it should ensure adequate warm, cooked foods in the diet.

Botanical Description

Physical characteristics and morphology of the Sheng Ma source plant

Sheng Ma comes from the dried rhizome of plants in the Ranunculaceae (buttercup) family. Three species are recognized in the Chinese Pharmacopoeia: Cimicifuga foetida L. (the classic "Chuan Sheng Ma" or Sichuan type), Cimicifuga dahurica (Turcz.) Maxim. (the northern "Bei Sheng Ma"), and Cimicifuga heracleifolia Kom. (the "Guan Sheng Ma" from the northeast).

C. foetida is a perennial herb growing 1 to 2 metres tall with erect, hollow, branching stems covered in fine hairs. The leaves are large, triangular in outline, and divided two to three times into three-parted pinnate leaflets. The terminal leaflets are rhombic (diamond-shaped) with serrated edges. It produces tall panicles of small whitish or greenish-white flowers from July to September, with the flower stalks densely covered in grayish or rust-coloured glandular hairs. The fruits are oblong follicles bearing 3 to 8 seeds with membranous, scale-like wings. The plant grows naturally in forest understories and mountain slope grasslands at elevations of 1,700 to 2,300 metres.

The medicinal rhizome is stout, blackish on the surface, irregular in shape with many branches forming a knotty mass. Its most distinctive feature is the round, hollow depressions on the upper surface where old stems once grew, giving it the folk names "ghost-face Sheng Ma" (鬼脸升麻) or "ghost-eye Sheng Ma" (鬼眼升麻).

Sourcing & Harvesting

Where Sheng Ma is sourced, when it's harvested or collected, and how to assess quality

Harvesting season

Autumn, after the aboveground parts wither. The rhizomes are dug up, cleaned of soil, sun-dried until the rootlets are dry, then the rootlets are singed off or removed, and the rhizome is fully dried.

Primary growing regions

The historically prized terroir region (道地产区) for Sheng Ma is Sichuan province (particularly the Aba/Ngawa region) and the Gansu-Qinghai border area on the southeastern edge of the Tibetan Plateau, producing the classic "Chuan Sheng Ma" (川升麻, C. foetida). Classical texts from the Shen Nong Ben Cao Jing onward note "produced in Yi Zhou" (modern Sichuan), and the Ben Cao Tu Jing states Sichuan-produced herb is superior. Major production regions today also include Liaoning, Jilin, and Heilongjiang provinces (for Guan Sheng Ma / C. heracleifolia and Bei Sheng Ma / C. dahurica), as well as Hebei, Shanxi, and Inner Mongolia. Wild-harvested rhizome from mountainous forests at 1,700-2,300m elevation is traditionally considered highest quality.

Quality indicators

Good quality Sheng Ma rhizome (especially the Sichuan type, C. foetida) should be compact, hard, and heavy relative to its size, with a dark blackish-brown to dark brown outer surface. The characteristic round, hollow stem-base depressions on the upper surface should show clear netlike (reticulate) grooves on their inner walls. The cross-section should be yellowish-green or pale yellowish-white with visible radial patterns in the wood, and should have a fibrous texture. The smell should be faint, and the taste slightly bitter and astringent. Avoid pieces that are too light (may indicate adulteration or poor development), excessively rootlet-covered, or that have a soft, spongy texture. The best-regarded variety historically is described as "inner white, outer black, and compact" (里白外黑而紧实).

Classical Texts

Key passages from the classical Chinese medical texts that describe Sheng Ma and its therapeutic uses

Shen Nong Ben Cao Jing (《神农本草经》)

Chinese: 升麻,一名周升麻,味甘、辛。生山谷。主辟百毒,杀百老殃鬼,辟温疾障稚毒蛊。

English: "Sheng Ma, also called Zhou Sheng Ma, is sweet and acrid in flavour. It grows in mountain valleys. It treats all manner of toxins, wards off pestilential warm diseases and poisonous parasites."


Ming Yi Bie Lu (《名医别录》)

Chinese: 主中恶腹痛,时气毒疠,头痛寒热,风肿诸毒,喉痛,口疮。

English: "It treats sudden abdominal pain from evil influences, seasonal epidemic toxins, headache with alternating chills and fever, wind-type swelling with various toxins, sore throat, and mouth sores."


Ben Cao Gang Mu (《本草纲目》, Li Shizhen)

Chinese: 消斑疹,行瘀血,治阳陷眩运,胸胁虚痛,久泄下痢后重,遗浊,带下,崩中,血淋,下血,阴痿足寒。

English: "It resolves macular rashes, moves Blood stasis, treats Yang sinking with dizziness, empty pain in the chest and flanks, chronic diarrhea and dysentery with tenesmus, turbid discharge, vaginal discharge, flooding and spotting, bloody painful urination, and lower body coldness with impotence."


Ben Cao Gang Mu (《本草纲目》, Li Shizhen, on the name)

Chinese: 其叶似麻,其性上升,故名。

English: "Its leaves resemble hemp (麻), and its nature is to ascend (升), hence the name Sheng Ma."

Historical Context

The history and evolution of Sheng Ma's use in Chinese medicine over the centuries

Sheng Ma was first recorded in the Shen Nong Ben Cao Jing as a "superior grade" (上品) herb, where its primary uses were to ward off toxins and pestilential diseases. The name literally means "ascending hemp" because, as Li Shizhen explained, its leaves resemble hemp and its therapeutic nature is to lift upward. Classical nicknames include "chicken bone Sheng Ma" (鸡骨升麻, referring to fine, dark specimens from Yunnan and Sichuan) and "ghost face Sheng Ma" (鬼脸升麻, referring to the hollow stem-base depressions on the rhizome that look like eyes or a face).

The understanding of Sheng Ma's functions evolved significantly over the centuries. In the earliest texts through the Tang dynasty, it was primarily valued for clearing Heat and toxins. The pivotal shift came during the Jin-Yuan period (12th-13th century): Zhang Yuansu first proposed that Sheng Ma could "raise Yang" and serve as a guiding herb for the Yangming (Stomach) channel. His student Li Dongyuan (Li Gao) developed this concept fully in his Pi Wei Lun (Treatise on the Spleen and Stomach), using Sheng Ma as a key ingredient in Bu Zhong Yi Qi Tang to lift sunken Spleen Qi. From this point onward, the "Yang-raising" function became so prominent that the original Heat-clearing indication was largely overshadowed. Qing dynasty physicians eventually restored a more balanced view, recognizing Sheng Ma as possessing both ascending and descending properties depending on dosage and context.

The botanical source of Sheng Ma also evolved historically. Early texts centred on the Sichuan species (C. foetida), but as the herb entered wider use, northeastern species (C. dahurica, C. heracleifolia) were gradually incorporated. The large-leaf species C. heracleifolia only became an official Pharmacopoeia source in the mid-20th century. Importantly, Sheng Ma should not be confused with the Western "black cohosh" (Cimicifuga racemosa), which is a different species used primarily for menopausal symptoms.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Sheng Ma

1

Comprehensive review: Traditional uses, phytochemistry, pharmacology, quality control and clinical studies of Cimicifugae Rhizoma (2024)

Zhang Q, Wei W, Jin X, Lu J, Chen S, Ogaji OD, Wang S, Du K, Chang Y, Li J. Chinese Medicine, 2024, 19(1):66.

This systematic review compiled research from 1993 to 2023 on all three Pharmacopoeia species of Sheng Ma. It documented over 300 chemical constituents (mainly cycloartane triterpenoid saponins, phenylpropanoids, and chromones) and summarized pharmacological effects including anti-inflammatory, anti-tumour, lipid-lowering, neuroprotective, and antiviral activities. The review also covered quality control methods and noted that isoferulic acid content is the current Pharmacopoeia standard marker.

PubMed
2

Cytotoxic cycloartane triterpenoid saponins from the rhizomes of Cimicifuga foetida (Preclinical, 2019)

Lu J, Peng XR, Shi QQ, et al. Natural Products and Bioprospecting, 2019, 9:263-270.

Researchers isolated actein (a key cycloartane triterpenoid) and four new related compounds from C. foetida rhizomes. The new compounds showed moderate broad-spectrum cytotoxicity against five human cancer cell lines (IC50 values of 4 to 16 micromolar). Actein has been shown in other work to suppress breast cancer growth via NF-kB and EGFR pathways, making these compounds of interest for potential anti-cancer drug development.

PubMed
3

Review: From origins, bioactive constituents to clinical outcomes of Cimicifugae Rhizoma (2006)

Li JX, Yu ZY. Current Medicinal Chemistry, 2006, 13(23):2927-2951.

This review catalogued over 200 compounds from Cimicifuga species and summarized evidence for multiple biological activities including anti-HIV, anti-inflammatory, anti-osteoporosis, anti-diabetic, and vasodilatory effects. It particularly highlighted the potential of cycloartane triterpenoids for anti-bone resorption activity relevant to postmenopausal osteoporosis, with detailed structure-activity relationships.

PubMed
4

Traditional uses, phytochemistry, pharmacology and toxicology of the genus Cimicifuga: A review (2017)

Guo YQ, Yin T, Wang XM, et al. Journal of Ethnopharmacology, 2017, 209:264-282.

A broad review covering seven Cimicifuga species with over 457 identified compounds. It confirmed pharmacological activities including menopausal symptom relief, anti-osteoporosis, antiviral, anti-tumour, and antioxidant effects. The review also addressed safety concerns, noting reported liver, cardiovascular, and nervous system toxicities with Cimicifuga preparations, emphasizing the need for careful dosing.

Research on individual TCM herbs is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.