Tiao Jing Cu Yun Wan

Menstruation-Regulating Fertility-Promoting Pills · 调经促孕丸

Also known as: Motherhood Form Pills, Tiaojing Cuyun Wan

A widely used Chinese patent medicine designed to support fertility and regulate menstrual cycles. It works by warming and strengthening the Kidneys and Spleen while gently activating blood circulation to address delayed periods, scanty menstruation with clots, cold pain in the lower abdomen, and difficulty conceiving due to underlying coldness and weakness in the body.

Origin Chinese Pharmacopoeia (中国药典); modern formulation by Beijing Tong Ren Tang — Modern (contemporary Chinese patent medicine, included in the Chinese Pharmacopoeia)
Composition 18 herbs
Lu Rong
King
Lu Rong
Yin Yang Huo
Deputy
Yin Yang Huo
Xian Mao
Deputy
Xian Mao
Tu Si Zi
Deputy
Tu Si Zi
Xu Duan
Assistant
Xu Duan
Sang Ji Sheng
Assistant
Sang Ji Sheng
Gou Qi Zi
Assistant
Gou Qi Zi
Fu Pen Zi
Assistant
Fu Pen Zi
+10
more
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Tiao Jing Cu Yun Wan is designed to correct these specific patterns.

Why Tiao Jing Cu Yun Wan addresses this pattern

This is the primary pattern addressed by Tiao Jing Cu Yun Wan. When both Kidney Yang and Spleen Qi are deficient, the body lacks the warming force needed to sustain normal reproductive function. The Kidneys govern reproduction, store Essence, and warm the uterus through the Ming Men fire. When Kidney Yang is weak, the uterus becomes cold, ovulation falters, and conception becomes difficult. Simultaneously, when the Spleen is weak, it cannot generate sufficient Qi and Blood to fill the Chong and Ren vessels, leading to scanty or absent periods. The formula's large group of Kidney-warming herbs (Lu Rong, Yin Yang Huo, Xian Mao, Tu Si Zi) directly restores Kidney Yang, while Shan Yao, Fu Ling, Huang Qi, and Lian Zi rebuild the Spleen foundation to ensure adequate Blood production.

A practitioner would look for one or more of these signs

Infertility

Prolonged inability to conceive

Irregular Menstruation

Delayed periods or irregular cycle

Scanty Menstruation

Reduced menstrual flow

Amenorrhea

Absent periods for extended time

Cold Lower Abdomen

Cold pain in the lower abdomen during menstruation

Chronic Lower Back Pain

Sore, cold lower back and knees

Eye Fatigue

Fatigue and general weakness

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Tiao Jing Cu Yun Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Spleen and Kidney Qi Deficiency Blood Stasis in the Uterus

TCM Interpretation

In TCM, the Kidneys are the organ system most directly responsible for reproduction. They store Essence (Jing), which governs fertility, egg maturation, and the body's capacity to conceive and sustain pregnancy. The Kidneys also govern the Chong and Ren vessels, the two extraordinary channels that directly control menstruation and the uterus. When Kidney Yang is deficient, the uterus receives insufficient warming, ovulation may fail to occur, and the endometrial lining may not develop properly for implantation.

The Spleen plays a critical supporting role: it transforms food into Qi and Blood, which nourish the Chong vessel. When the Spleen is weak, Blood production drops, the menstrual cycle becomes irregular or scanty, and the body lacks the resources to support a pregnancy. When Blood stasis compounds these deficiencies, the uterine environment becomes further impaired.

Why Tiao Jing Cu Yun Wan Helps

Tiao Jing Cu Yun Wan addresses infertility through a three-pronged approach. First, Lu Rong, Yin Yang Huo, Xian Mao, and Tu Si Zi warm Kidney Yang and replenish Essence to restore ovarian function and warm the uterus. Second, Shan Yao, Huang Qi, Fu Ling, and Lian Zi strengthen the Spleen to boost Qi and Blood production, ensuring the Chong vessel is well nourished. Third, Dan Shen, Chi Shao, and Ji Xue Teng invigorate Blood to clear stasis from the uterus and improve endometrial receptivity. Modern research supports that Yin Yang Huo may increase estrogen receptor density and improve endometrial thickness, while Dan Shen and Ji Xue Teng can improve uterine blood flow and reduce vascular resistance.

Also commonly used for

Amenorrhea

Secondary amenorrhea

Amenorrhea

Menstrual pain with cold sensation and clots

Scanty Menstruation

Hypomenorrhea (reduced menstrual flow)

Anovulation

Ovulatory dysfunction

Luteal Phase Defect

Insufficient corpus luteum function

What This Formula Does

Every TCM formula has a specific set of actions — here's what Tiao Jing Cu Yun Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Tiao Jing Cu Yun Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Tiao Jing Cu Yun Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Tiao Jing Cu Yun Wan works at the root level.

In TCM, a woman's fertility depends on a chain of interconnected functions: the Kidneys must produce sufficient essence (Jing) to fuel the reproductive system, the Spleen must generate enough Qi and Blood to nourish the uterus, and the Blood must flow freely through the Chong and Ren vessels to produce regular menstruation and support conception. When this chain breaks down at the root level, the result is a pattern called Spleen-Kidney Yang Deficiency with Blood Stasis (脾肾阳虚、瘀血阻滞).

The core problem begins with Kidney Yang deficiency. The Kidneys are considered the root of reproductive function. When Kidney Yang is weak, the body lacks the warming, activating force needed to mature eggs, support ovulation, and maintain a hospitable uterine environment. The uterus becomes "cold" (宫寒), leading to delayed periods, scanty flow, and difficulty conceiving. At the same time, a weakened Spleen fails to produce sufficient Qi and Blood from food, meaning the reproductive organs are undernourished. Qi deficiency further compounds the problem: when Qi is too weak to move Blood properly, Blood stagnates. This creates clots in the menstrual flow, causes cold pain in the lower abdomen during periods, and obstructs the uterine vessels that need to be open and well-perfused for an embryo to implant.

The result is a vicious cycle: deficiency leads to stagnation, and stagnation worsens deficiency. Periods become delayed, scanty, and painful. The lining of the uterus does not build up properly. Ovulation may fail or be irregular. And even when conception occurs, the cold, stagnant uterine environment may not sustain it. Tiao Jing Cu Yun Wan addresses all three aspects simultaneously: warming Kidney Yang to restore the reproductive fire, strengthening the Spleen to rebuild Qi and Blood, and activating Blood circulation to clear stasis from the uterus and pelvic vessels.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly sweet and slightly bitter. Sweet from the many tonifying herbs (Shan Yao, Lian Zi, Huang Qi, Gou Qi Zi, Tu Si Zi) to nourish and supplement, slightly bitter from Dan Shen and Chi Shao to activate Blood circulation.

Channels Entered

Kidney Spleen Liver Chong Mai (冲脉) Penetrating Vessel Ren Mai (任脉) Conception Vessel

Ingredients

18 herbs

The herbs that make up Tiao Jing Cu Yun Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Lu Rong

Lu Rong

Pilose antlers

Dosage 5g
Temperature Warm
Taste Salty, Sweet
Organ Affinity Kidneys, Liver
Preparation Hair removed (去毛)

Role in Tiao Jing Cu Yun Wan

The chief herb of the formula, Lu Rong powerfully tonifies Kidney Yang, replenishes Essence (Jing), and nourishes Blood. It directly addresses the root deficiency of Kidney Yang that underlies infertility, amenorrhea, and cold in the uterus. It also strengthens the Chong and Ren vessels, which are essential for menstruation and conception.
Deputies — Assists and enhances the King
Yin Yang Huo

Yin Yang Huo

Epimedium herbs

Dosage 10g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Kidneys, Liver
Preparation Processed with sheep fat (炙)

Role in Tiao Jing Cu Yun Wan

Strongly warms Kidney Yang and tonifies the Ming Men fire. Works synergistically with Lu Rong to reinforce Kidney warming. Modern research indicates it may support ovarian function and improve endometrial receptivity.
Xian Mao

Xian Mao

Curculigo rhizomes

Dosage 10g
Temperature Hot
Taste Pungent
Organ Affinity Spleen, Kidneys, Liver

Role in Tiao Jing Cu Yun Wan

Warms Kidney Yang and expels cold-dampness from the lower body. Pairs with Yin Yang Huo (the classical Er Xian pair used for warming the Kidneys) to strengthen the warming and Yang-tonifying effect of the formula.
Tu Si Zi

Tu Si Zi

Cuscuta seeds

Dosage 15g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver, Spleen

Role in Tiao Jing Cu Yun Wan

Tonifies both Kidney Yin and Yang in a balanced way, supplements Essence, and secures the Chong and Ren vessels. It is a key fertility herb that nourishes without being too drying or too warming, supporting both ovulation and embryo implantation.
Assistants — Supports or moderates other herbs
Xu Duan

Xu Duan

Japanese teasel roots

Dosage 10g
Temperature Warm
Taste Bitter, Sour
Organ Affinity Kidneys, Liver

Role in Tiao Jing Cu Yun Wan

Tonifies the Liver and Kidneys, strengthens sinews and bones, and promotes blood circulation. It also calms the fetus and is traditionally used for Kidney deficiency with lower back pain and threatened miscarriage, supporting the reproductive function of the formula.
Sang Ji Sheng

Sang Ji Sheng

Mulberry Mistletoe

Dosage 10g
Temperature Neutral
Taste Bitter, Sweet
Organ Affinity Kidneys, Liver

Role in Tiao Jing Cu Yun Wan

Tonifies the Liver and Kidneys, strengthens sinews and bones, and nourishes Blood. Works with Xu Duan and Tu Si Zi to support the Kidney foundation. Traditionally used for lower back and knee pain and to calm the fetus.
Gou Qi Zi

Gou Qi Zi

Goji berries

Dosage 10g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Tiao Jing Cu Yun Wan

Nourishes Liver and Kidney Yin and Blood, supplementing the Essence that feeds reproductive capacity. Balances the warming herbs by adding a nourishing Yin component, preventing excessive dryness.
Fu Pen Zi

Fu Pen Zi

Palmleaf raspberries

Dosage 10g
Temperature Warm
Taste Sour, Sweet
Organ Affinity Urinary Bladder, Kidneys

Role in Tiao Jing Cu Yun Wan

Tonifies and stabilizes the Kidneys, secures Essence, and astringes urine. Supports Kidney function and works alongside Tu Si Zi and Gou Qi Zi as part of the classical Wu Zi group of fertility-supporting seeds.
Shan Yao

Shan Yao

Yam

Dosage 30g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Lungs, Spleen

Role in Tiao Jing Cu Yun Wan

Tonifies both Spleen and Kidney simultaneously, supplementing Qi and nourishing Yin. Used at the highest dose in the formula (30g), it is the primary Spleen-supporting herb, ensuring the postnatal foundation generates adequate Qi and Blood to support fertility.
Lian Zi

Lian Zi

Lotus seeds

Dosage 10g
Temperature Neutral
Taste Sour, Sweet
Organ Affinity Heart, Kidneys, Spleen
Preparation Core removed (去心)

Role in Tiao Jing Cu Yun Wan

Tonifies the Spleen, benefits the Kidneys, astringes Essence, and calms the spirit. The core is removed (去心) to eliminate its bitter, Heart-clearing component, leaving its tonifying and astringent properties to support the Spleen-Kidney axis.
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 15g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Tiao Jing Cu Yun Wan

Strengthens the Spleen and leaches dampness. Supports the Spleen-tonifying function of the formula and ensures that fluids are properly transformed, preventing dampness from obstructing the reproductive organs.
Huang Qi

Huang Qi

Milkvetch roots

Dosage 10g
Temperature Warm
Taste Sweet
Organ Affinity Lungs, Spleen

Role in Tiao Jing Cu Yun Wan

Tonifies Spleen Qi and raises Yang Qi. Supports the postnatal source of Qi and Blood production, which is essential for nourishing the Chong and Ren vessels and sustaining menstruation and pregnancy.
Bai Shao

Bai Shao

White peony roots

Dosage 15g
Temperature Neutral
Taste Bitter, Sour
Organ Affinity Liver, Spleen

Role in Tiao Jing Cu Yun Wan

Nourishes Blood, preserves Yin, softens the Liver, and alleviates pain. Helps regulate the Liver to ensure smooth flow of Qi and Blood in the uterus, and moderates the drying nature of the warming herbs.
Suan Zao Ren

Suan Zao Ren

Jujube seeds

Dosage 10g
Temperature Neutral
Taste Sour, Sweet
Organ Affinity Gallbladder, Heart, Liver
Preparation Dry-fried (炒)

Role in Tiao Jing Cu Yun Wan

Nourishes Heart Blood, calms the spirit, and benefits the Liver. Addresses the emotional and sleep disturbances that often accompany infertility and menstrual irregularity due to Blood deficiency. Dry-fried processing enhances its calming properties.
Gou Teng

Gou Teng

Gambir stems and thorns

Dosage 10g
Temperature Cool
Taste Sweet
Organ Affinity Liver, Pericardium

Role in Tiao Jing Cu Yun Wan

Clears Liver Heat and calms Liver Yang rising. Acts as a restraining assistant to prevent the large number of warming, Yang-tonifying herbs from generating excessive heat or causing Liver Yang to flare, which could disturb the menstrual cycle.
Dan Shen

Dan Shen

Red sage roots

Dosage 15g
Temperature Cool
Taste Bitter
Organ Affinity Heart, Liver

Role in Tiao Jing Cu Yun Wan

Invigorates Blood, dispels stasis, and cools the Blood. Addresses the Blood stasis component of the pathomechanism, improving circulation to the uterus and supporting endometrial receptivity. It also helps prevent the warming herbs from causing Blood Heat.
Chi Shao

Chi Shao

Red peony roots

Dosage 15g
Temperature Cool
Taste Bitter
Organ Affinity Liver

Role in Tiao Jing Cu Yun Wan

Clears Heat from the Blood and invigorates Blood circulation. Works with Dan Shen to remove Blood stasis and improve pelvic microcirculation, while its cooling nature balances the warmth of the Yang-tonifying herbs.
Envoy — Directs the formula to its target
Ji Xue Teng

Ji Xue Teng

Spatholobus stems

Dosage 30g
Temperature Warm
Taste Bitter, Sweet
Organ Affinity Spleen, Heart, Liver

Role in Tiao Jing Cu Yun Wan

Tonifies and invigorates Blood simultaneously, unblocks the channels and collaterals, and warms the lower back and knees. Used at a high dose (30g), it harmonizes the entire formula by bridging its tonifying and Blood-moving strategies, ensuring that newly generated Blood flows freely through the Chong and Ren vessels.

Why This Combination Works

How the herbs in Tiao Jing Cu Yun Wan complement each other

Overall strategy

Tiao Jing Cu Yun Wan addresses a root deficiency of Kidney Yang and Spleen Qi combined with secondary Blood stasis obstructing the uterus. The prescription strategy is to warm and supplement the Kidney foundation to restore the source of reproductive vitality, strengthen the Spleen to generate Qi and Blood, and simultaneously invigorate Blood to clear stasis from the Chong and Ren vessels so that menstruation normalizes and conception becomes possible.

King herbs

Lu Rong (Deer Velvet Antler) is the sole King herb. It is the most powerful Yang-tonifying substance in the materia medica, directly supplementing Kidney Yang, replenishing Essence, and nourishing the Blood of the Chong and Ren vessels. Even at a relatively small dose (5g), its potency makes it the driving force of the formula, targeting the core deficiency of Kidney Yang that underlies cold in the uterus, failure to ovulate, and inability to conceive.

Deputy herbs

Yin Yang Huo (Epimedium) and Xian Mao (Curculigo) form the classical warming pair that strongly reinforces Kidney Yang and Ming Men fire. Tu Si Zi (Cuscuta Seed) complements them by tonifying both Kidney Yin and Yang in a balanced, gentle manner, securing Essence and stabilizing the Chong and Ren vessels. Together these three deputies amplify the King herb's warming and Kidney-supplementing action from multiple angles.

Assistant herbs

Reinforcing assistants for the Kidneys: Xu Duan, Sang Ji Sheng, Gou Qi Zi, and Fu Pen Zi further tonify the Liver and Kidneys, nourish Essence, and strengthen the lower back. Several of these overlap with ingredients of the classical fertility formula Wu Zi Yan Zong Wan, providing a broad Kidney-supplementing foundation. Gou Qi Zi also nourishes Yin, preventing the warming herbs from depleting fluids.

Reinforcing assistants for the Spleen: Shan Yao (at the formula's highest dose of 30g), Fu Ling, Huang Qi, and Lian Zi strengthen the Spleen, boost Qi production, and ensure adequate Blood generation. Since the Spleen is the postnatal root of Qi and Blood, strengthening it is essential to sustain the menstrual cycle and support pregnancy.

Blood-nourishing and spirit-calming assistants: Bai Shao nourishes Blood and softens the Liver, while Suan Zao Ren calms the spirit, addresses insomnia, and nourishes Heart Blood. These address the emotional strain and Blood deficiency that commonly accompany chronic infertility.

Blood-invigorating assistants: Dan Shen and Chi Shao are the Blood-moving pair that directly addresses the Blood stasis component, clearing clots, improving uterine microcirculation, and enhancing endometrial receptivity.

Restraining assistant: Gou Teng clears Liver Heat and subdues Liver Yang, counterbalancing the numerous warm and hot Yang-tonifying herbs to prevent them from generating pathological heat or causing headaches and irritability.

Envoy herbs

Ji Xue Teng (Spatholobus Stem) serves as the envoy at a high dose of 30g. It uniquely bridges the formula's two main strategies by both tonifying and invigorating Blood, and it directs the formula's effects through the channels and collaterals to the uterus and lower body. It harmonizes the tonifying and Blood-moving components into a unified therapeutic action.

Notable synergies

Lu Rong paired with Yin Yang Huo and Xian Mao creates a powerful triple warming combination that addresses even severe Kidney Yang deficiency with cold uterus. Tu Si Zi, Gou Qi Zi, and Fu Pen Zi together echo the classical Wu Zi Yan Zong Wan seed combination for fertility support. Dan Shen paired with Chi Shao ensures Blood stasis is cleared without damaging normal Blood, while Bai Shao and Gou Teng together prevent the warming herbs from disturbing the Liver, keeping Qi flow smooth and preventing menstrual irregularity from Liver constraint.

How to Prepare

Traditional preparation instructions for Tiao Jing Cu Yun Wan

This formula is a standardized Chinese patent medicine (中成药) prepared as honey-bound water pills (水蜜丸). The eighteen herbs are ground into fine powder, sieved, and mixed evenly. For every 100g of powder, 40 to 50g of refined honey is added with an appropriate amount of water, then formed into pills, dried, and coated with a gelatin coating.

Standard dosage: take 5g (approximately 50 pills) orally, twice daily. Begin from the fifth day of the menstrual cycle and continue for 20 consecutive days. For those without a regular cycle, take for 20 consecutive days each month. A typical course of treatment is three months. The pills should be swallowed with warm water.

Common Modifications

How practitioners adapt Tiao Jing Cu Yun Wan for specific situations

Added
Tao Ren

9g, to strongly break Blood stasis

Hong Hua

6g, to invigorate Blood and dispel stasis

When Blood stasis is more prominent than deficiency, adding Tao Ren and Hong Hua strengthens the formula's Blood-moving capacity to break through stubborn clots and improve uterine blood flow.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Tiao Jing Cu Yun Wan should not be used or requires extra caution

Avoid

Yin deficiency with Empty Heat (Yin Xu Huo Wang). This formula is predominantly warming and Yang-tonifying. Using it in someone with Yin deficiency Heat signs (night sweats, hot flashes, dry mouth, red tongue with little coating) would intensify the Heat and worsen symptoms.

Avoid

Excessive menstrual bleeding (menorrhagia). The Blood-activating herbs (Dan Shen, Chi Shao, Ji Xue Teng) may increase bleeding. This formula is designed for scanty periods, not heavy ones.

Avoid

Active menstruation. The formula should be stopped during the menstrual period itself and resumed on day 5 of the cycle, as taking it during menstruation may disrupt the normal shedding phase.

Avoid

Confirmed pregnancy. Once pregnancy is established, this formula should be discontinued. It contains Blood-moving herbs that are not appropriate during pregnancy.

Caution

Acute febrile illness or common cold. The warming, tonifying nature of this formula can trap pathogens and worsen fever. Suspend use until the acute illness resolves.

Caution

Damp-Heat patterns of the lower Jiao (e.g. pelvic inflammatory disease with yellow discharge, foul odor, burning urination). The warming herbs may aggravate Damp-Heat conditions.

Caution

Polycystic Ovary Syndrome (PCOS) with elevated androgens or LH. The Kidney Yang-tonifying herbs (Lu Rong, Yin Yang Huo, Xian Mao) may further raise androgen and LH levels. Use only under practitioner supervision with monitoring.

Caution

Allergic or hypersensitive constitution. Rare cases of skin rash have been reported. Discontinue if allergic reactions occur.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated once pregnancy is confirmed. The formula contains several Blood-activating herbs (Dan Shen/Salvia root, Chi Shao/Red Peony root, Ji Xue Teng/Spatholobus) that promote blood circulation and may pose a risk to pregnancy stability. The official product labeling states that there is no safety research data on effects to offspring (尚无本药品对子代安全性研究资料). The formula is designed for use during the pre-conception period to regulate menstruation and promote ovulation, not during pregnancy. Women should discontinue use as soon as pregnancy is suspected or confirmed and consult their practitioner. If the formula was taken unknowingly during very early pregnancy, the risk is likely low given the gentle pill form, but a healthcare provider should be informed.

Breastfeeding

No formal safety data exists for use during breastfeeding. The formula contains Lu Rong (Deer Antler Velvet), Yin Yang Huo (Epimedium), and Xian Mao (Curculigo), which are potent Kidney Yang tonics with potential hormonal activity. Epimedium (Yin Yang Huo) contains icariin, which has been shown to have estrogen-like effects, and these phytoestrogenic compounds could theoretically transfer through breast milk. Additionally, the Blood-moving herbs (Dan Shen, Chi Shao) may alter the quality or quantity of breast milk. The formula is designed to regulate menstruation and promote conception, making it generally unnecessary during the breastfeeding period. If menstrual regulation is needed postpartum while breastfeeding, consult a qualified practitioner for a more appropriate formula.

Children

This formula is not suitable for children. It is designed exclusively for adult women of reproductive age who are experiencing menstrual irregularities or infertility due to Spleen-Kidney Yang deficiency with Blood stasis. The Kidney Yang-tonifying herbs (Lu Rong, Yin Yang Huo, Xian Mao) have hormonal activity that would be inappropriate for children and adolescents whose endocrine systems are still developing. The official product labeling does not include pediatric dosing information.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Tiao Jing Cu Yun Wan

Hormonal medications and oral contraceptives: The formula contains multiple herbs with phytoestrogenic or hormone-modulating activity. Lu Rong (Deer Antler Velvet), Yin Yang Huo (Epimedium, containing icariin), and Xian Mao (Curculigo) may interact with hormone replacement therapy, oral contraceptives, or fertility drugs such as Clomiphene Citrate and Letrozole. While some clinical studies have used the formula alongside Letrozole for ovulation induction, this should only be done under close medical supervision.

Anticoagulant and antiplatelet medications: Dan Shen (Salvia miltiorrhiza) is well documented to enhance the anticoagulant effect of Warfarin by inhibiting CYP enzymes involved in Warfarin metabolism, potentially increasing INR and bleeding risk. Chi Shao (Red Peony) and Ji Xue Teng (Spatholobus) also have antiplatelet activity. Patients on Warfarin, Heparin, Aspirin, or other blood-thinning drugs should use this formula only with medical oversight.

Antihypertensive drugs: Gou Teng (Uncaria rhynchophylla) has documented hypotensive effects. Combined use with antihypertensive medications may cause an additive drop in blood pressure.

Sedative medications: Suan Zao Ren (Ziziphus, fried) has known sedative properties. Combined use with benzodiazepines, sleep medications, or other CNS depressants may produce additive drowsiness.

Usage Guidance

Practical advice for getting the most out of Tiao Jing Cu Yun Wan

Best time to take

Twice daily, 30 minutes after meals, with warm water. Begin on the 5th day of the menstrual cycle and stop when menstruation arrives.

Typical duration

Take for 20 consecutive days per menstrual cycle (starting from cycle day 5), repeated for 3 monthly cycles. Reassess with a practitioner after 3 months.

Dietary advice

Avoid cold and raw foods (ice water, raw salads, chilled fruit, ice cream) while taking this formula, as they can counteract the warming action and further impair Spleen Yang. Also limit greasy, deep-fried, and overly rich foods that burden the Spleen and generate Dampness. Spicy and excessively hot foods should be used in moderation to avoid consuming Yin fluids. Favor warm, cooked, easily digestible foods. Warming soups, congee, gently cooked vegetables, lamb, chicken, walnuts, black sesame, goji berries, and red dates support the formula's Kidney-warming and Blood-nourishing actions. Moderate portions of warming spices like ginger, cinnamon, and fennel can complement the formula's effects.

Tiao Jing Cu Yun Wan originates from Chinese Pharmacopoeia (中国药典); modern formulation by Beijing Tong Ren Tang Modern (contemporary Chinese patent medicine, included in the Chinese Pharmacopoeia)

Classical Texts

Key passages from the classical Chinese medical texts that first described Tiao Jing Cu Yun Wan and its clinical use

Tiao Jing Cu Yun Wan (调经促孕丸) is a modern Chinese patent medicine (中成药) rather than a classical formula from an ancient text. It does not have direct quotations from the classical canon. However, the theoretical principles underlying its design are deeply rooted in classical gynecological thought:

The Huang Di Nei Jing Su Wen states regarding kidney function and reproduction: 「女子七岁肾气盛,齿更发长;二七而天癸至,任脉通,太冲脉盛,月事以时下,故有子」 ("At age seven a girl's Kidney Qi flourishes, her teeth change and hair grows long; at twice seven Tian Gui arrives, the Ren vessel is open, the Chong vessel is abundant, menstruation comes on time, and so she can conceive.") This passage from the Su Wen chapter on the Heavenly Truth of Antiquity (上古天真论) establishes the foundational idea that Kidney Qi and the Chong-Ren vessels govern menstruation and fertility, which is the core theoretical basis for this formula.

The Jing Yue Quan Shu (景岳全书) by Zhang Jiebin discusses the treatment of infertility: 「种子之方,本无定轨,因人而药,各有所宜」 ("Prescriptions for promoting conception have no fixed path; one must tailor the medicine to the person, each having their own appropriate approach.") This principle of individualized treatment for infertility resonates with Tiao Jing Cu Yun Wan's comprehensive approach of simultaneously tonifying Kidney, strengthening Spleen, and moving Blood.

Historical Context

How Tiao Jing Cu Yun Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Tiao Jing Cu Yun Wan is a modern Chinese patent medicine (中成药) developed in the People's Republic of China, most famously produced by Beijing Tong Ren Tang (北京同仁堂), one of China's oldest and most prestigious pharmaceutical companies, founded in 1669 during the Qing Dynasty. The formula carries the National Drug Approval Number Z11020027.

While not derived from a single classical text, the formula's design synthesizes several streams of traditional gynecological thought. Its Kidney-warming core draws from the classical principle that the Kidneys govern reproduction, as taught in the Nei Jing and elaborated by later physicians such as Zhang Jingyue (张景岳) of the Ming Dynasty, who emphasized Kidney supplementation as the foundation for treating infertility. The integration of Spleen tonification with Kidney warming reflects the Ming-Qing era understanding that the Spleen's role in generating postnatal Qi and Blood is essential for reproductive health. The Blood-activating component follows the gynecological teaching that menstrual disorders almost always involve some degree of Blood stasis.

In contemporary clinical practice, Tiao Jing Cu Yun Wan has become one of the most widely used Chinese patent medicines for female infertility in China. It is commonly prescribed for hypothalamic-pituitary-ovarian axis dysfunction, luteal phase defect, anovulatory infertility, and secondary amenorrhea. Researchers at Shanghai University of Traditional Chinese Medicine have studied a closely related research formula also called "Tiaojing Cuyun Recipe" (ZHU's Tiaojing Cuyun Recipe) in multiple preclinical and clinical studies, building an evidence base for the approach of combining Kidney tonification with Blood activation for fertility support.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Tiao Jing Cu Yun Wan

1

Tiaojing Cuyun Recipe Enhances Pregnancy Outcome via the VEGF/PI3K/AKT/eNOS Signaling Pathway in EID Mice (Preclinical animal study, 2022)

Huang H, Xia L, Xia Y, Yan Y, Jiang Z, Zhao P, Dong L. Disease Markers. 2022;2022:9461444.

This mouse study found that the Tiaojing Cuyun Recipe significantly increased the number of embryo implantation sites in mice with experimentally induced embryo implantation dysfunction. The formula improved endometrial receptivity by upregulating VEGF expression, activating the PI3K/AKT/eNOS signaling pathway, and restoring estrogen and progesterone receptor expression in uterine tissue.

PubMed
2

Treatment of Anovulatory Infertility with Shen Deficiency Syndrome by ZHU's Tiaojing Cuyun Recipe: a Clinical Evaluation (RCT, 2015)

Lin Y, Dong L. Zhongguo Zhong Xi Yi Jie He Za Zhi (Chinese Journal of Integrated Traditional and Western Medicine). 2015;35(10):1181-1185.

This randomized controlled trial compared ZHU's Tiaojing Cuyun Recipe against Clomiphene Citrate in 80 women with anovulatory infertility and Kidney deficiency syndrome. Over two courses (3 menstrual cycles each), the study assessed pregnancy rates and abortion rates, providing clinical evidence for the recipe's efficacy in treating anovulatory infertility.

PubMed
3

Tiaojing Cuyun Recipe Inhibits Ferroptosis through SLC7A11/GSH/GPX4 Axis to Improve Endometrial Receptivity (Preclinical study, 2025)

Authors not fully confirmed from search. Journal of Traditional Chinese Medical Sciences. 2025.

This animal study demonstrated that the Tiaojing Cuyun Recipe improved endometrial receptivity in mice with embryo implantation dysfunction by inhibiting ferroptosis (a form of iron-dependent cell death) in endometrial tissue, working through the SLC7A11/GSH/GPX4 signaling axis. The findings suggest a novel mechanism by which the formula may protect the uterine lining.

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Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.