Herb Stem (茎 jīng)

Ji Xue Teng

Spatholobus stem · 鸡血藤

Spatholobus suberectus Dunn · Caulis Spatholobi

Also known as: Chicken Blood Vine, Spatholobus vine, Millettia stem,

Images shown are for educational purposes only

Ji Xue Teng (Spatholobus stem) is a widely used herb in Chinese medicine valued for its gentle ability to both nourish the Blood and improve its circulation. It is most commonly used for menstrual problems such as painful, irregular, or absent periods, and for joint or muscle pain accompanied by numbness or stiffness. Its name, meaning "chicken blood vine," comes from the blood-red juice that flows when its stem is cut.

TCM Properties

Temperature

Warm

Taste

Bitter (苦 kǔ), Sweet (甘 gān)

Channels entered

Heart, Liver, Kidneys

Parts used

Stem (茎 jīng)

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What This Herb Does

Every herb has a specific set of actions — here's what Ji Xue Teng does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Ji Xue Teng is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Ji Xue Teng performs to restore balance in the body:

How these actions work

'Invigorates Blood and tonifies Blood' means Ji Xue Teng can both get stagnant Blood moving and nourish Blood that is depleted. This is a rare and valuable dual action. Most herbs that move Blood tend to be drying or drastic, but Ji Xue Teng is gentle in nature. It moves without breaking and tonifies without causing stagnation. This makes it especially suited for conditions where Blood Deficiency and Blood Stasis coexist, such as a pale complexion with sharp menstrual cramps. It is considered a key herb for gynaecological conditions where the Blood needs both replenishing and freeing.

'Regulates menstruation and stops pain' refers to its strong affinity for the Liver channel, which governs the smooth flow of Blood and is closely tied to the menstrual cycle. Because Ji Xue Teng can both invigorate and nourish Blood, it addresses painful periods (dysmenorrhoea), irregular periods, or absent periods (amenorrhoea) regardless of whether the root cause is Blood Deficiency or Blood Stasis. It is regarded as a primary herb for menstrual regulation in Chinese medicine.

'Relaxes sinews and unblocks collaterals' means this herb can ease stiffness, numbness, and pain in the muscles, tendons, and joints. The collaterals (luò) are the fine branches of the channel network. When Blood fails to nourish the sinews, or when stagnation blocks the collaterals, numbness, weakness, or joint pain can result. Ji Xue Teng's warming nature and Blood-moving action help restore circulation through these fine networks, making it useful for conditions like Wind-Damp painful obstruction (bì zhèng), limb numbness, and even paralysis.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony. Ji Xue Teng is used to help correct these specific patterns.

Why Ji Xue Teng addresses this pattern

Ji Xue Teng directly nourishes the Blood through its sweet taste and warm nature, entering the Liver channel where Blood is stored. When Blood is insufficient, the body shows signs of pallor, dizziness, and scanty menstruation. Ji Xue Teng's tonifying action replenishes the Blood while its gentle invigorating quality ensures that newly formed Blood circulates properly rather than pooling. This dual action makes it particularly well-suited for Blood Deficiency where there is also an element of poor circulation.

A practitioner would look for one or more of these signs

Dull Pale Complexion

Sallow or pale face from insufficient Blood

Dizziness

Dizziness from Blood failing to nourish the head

Irregular Menstruation

Scanty or delayed periods due to Blood Deficiency

Skin Numbness

Numbness in the limbs from Blood failing to nourish the sinews

Commonly Used For

These are conditions where Ji Xue Teng is frequently used — but only when they arise from the specific patterns it addresses, not in all cases

Arises from: Blood Deficiency Blood Stasis

TCM Interpretation

In TCM, menstrual regularity depends on the Liver storing sufficient Blood and releasing it smoothly. Irregular periods can arise from two main directions: Blood Deficiency (where there simply is not enough Blood to fill the uterus on schedule) or Blood Stasis (where Blood is present but stuck, failing to flow freely). Many women have elements of both, as prolonged stasis can consume Blood, and prolonged deficiency can slow circulation and create stasis. The Liver and the Kidney channels are the primary organ systems involved.

Why Ji Xue Teng Helps

Ji Xue Teng is considered a key herb for menstrual regulation precisely because it addresses both sides of the problem at once. Its bitter taste disperses stagnant Blood, while its sweet taste and warm nature nourish and replenish Blood. It enters the Liver channel, directly targeting the organ responsible for menstrual flow. Classical sources describe it as 'moving without breaking, tonifying without stagnating,' meaning it gently restores proper menstrual function without being overly harsh or cloying.

Also commonly used for

Premenstrual Pain

Dysmenorrhoea from Blood Stasis or Blood Deficiency

Amenorrhea

Absent periods from Blood Stasis or Blood Deficiency

Osteoarthritis

Degenerative joint pain with stiffness and reduced mobility

Skin Numbness

Peripheral numbness from Blood Deficiency or stasis

Leukopenia

Low white blood cell count, especially after chemotherapy or radiation

Sciatica

Lower back and leg pain with numbness along the nerve pathway

Cervical Spondylosis

Neck stiffness and pain radiating to the arms

Herb Properties

Every herb has an inherent temperature, taste, and affinity for specific channels — these properties determine how it interacts with the body

Temperature

Warm

Taste

Bitter (苦 kǔ), Sweet (甘 gān)

Channels Entered

Heart Liver Kidneys

Parts Used

Stem (茎 jīng)

Dosage & Preparation

These are general dosage guidelines for Ji Xue Teng — always follow your practitioner's recommendation, as dosages vary based on the formula and your individual condition

Standard dosage

9-15g

Maximum dosage

Up to 30g in standard decoction for conditions like anemia or severe Blood deficiency; up to 60g daily has been reported in clinical practice for treating severe anemia and leukopenia, under practitioner supervision only.

Dosage notes

Use lower doses (9-15g) for general Blood-nourishing and menstrual-regulating purposes. Use higher doses (15-30g) for more significant Blood stasis conditions, wind-damp impediment pain, or numbness and paralysis. For treating leukopenia (low white blood cell count), particularly that associated with chemotherapy or radiation therapy, clinical reports often use 30-60g per day. The herb can also be prepared as a wine infusion (浸酒) for joint pain and rheumatic conditions, or boiled into a concentrated paste (膏) for long-term tonic use. When using large doses, practitioners typically monitor for signs of excessive Blood movement.

Preparation

No special decoction handling required. Ji Xue Teng slices are simply added to the decoction pot and boiled with other herbs in the standard manner. For wine preparations, the sliced herb is soaked in rice wine or grain alcohol. It can also be boiled down into a concentrated paste (鸡血藤膏) for long-term use.

Processing Methods

In TCM, the same herb can be prepared in different ways to change its effects — here's how processing alters what Ji Xue Teng does

Processing method

The sliced herb is stir-fried with rice wine (huáng jiǔ) until the wine is fully absorbed and the slices are slightly darker.

How it changes properties

Wine-processing enhances the herb's Blood-invigorating and collateral-opening actions by leveraging wine's ascending and dispersing nature. The warming effect is slightly amplified, and the herb's ability to penetrate the channels and relieve pain is strengthened. The Blood-tonifying action remains but is secondary to the enhanced movement of Blood.

When to use this form

Preferred when Blood Stasis is the primary problem, such as severe dysmenorrhoea with dark clots, fixed joint pain, or numbness from stagnant Blood in the collaterals. The wine-processed form is stronger for moving Blood and relieving pain than the raw form.

Common Herb Pairs

These ingredients are traditionally combined with Ji Xue Teng for enhanced therapeutic effect

Dang Gui
Dang Gui 1:1 (e.g. Ji Xue Teng 15g : Dang Gui 15g)

Together, Ji Xue Teng and Dang Gui form a powerful Blood-nourishing and Blood-invigorating pair. Dang Gui is the stronger Blood tonic and also moistens the Intestines, while Ji Xue Teng contributes additional collateral-opening and sinew-relaxing actions. The combination addresses Blood Deficiency and Blood Stasis simultaneously.

When to use: Menstrual disorders (irregular periods, dysmenorrhoea, amenorrhoea) caused by Blood Deficiency with Blood Stasis, or anaemia with poor peripheral circulation.

Huang Qi
Huang Qi Huang Qi 30g : Ji Xue Teng 30g (equal parts, large doses)

Huang Qi tonifies Qi while Ji Xue Teng tonifies and invigorates Blood. Since Qi is the commander of Blood, combining a Qi tonic with a Blood tonic enhances Blood production and circulation. This pair is especially valued for boosting white blood cell and red blood cell counts.

When to use: Leukopenia (low white blood cell count) following chemotherapy or radiation therapy, anaemia, or chronic fatigue with Blood Deficiency and Qi Deficiency.

Chuan Xiong
Chuan Xiong Ji Xue Teng 15-30g : Chuan Xiong 6-10g

Chuan Xiong is a potent Blood-invigorating and Qi-moving herb that targets the head and upper body, while Ji Xue Teng moves Blood more gently and throughout the channels and collaterals. Together they amplify Blood circulation, relieve pain, and regulate menstruation more effectively than either alone.

When to use: Dysmenorrhoea with Blood Stasis, headache from Blood Stasis (especially with concurrent Blood Deficiency), or Wind-Damp Bi with prominent pain.

Yi Mu Cao
Yi Mu Cao 1:1 (e.g. Ji Xue Teng 15g : Yi Mu Cao 15g)

Yi Mu Cao (Motherwort) strongly invigorates Blood and regulates menstruation, with particular affinity for the uterus. Paired with Ji Xue Teng, the Blood-moving effect is strengthened while Ji Xue Teng's Blood-tonifying quality prevents Yi Mu Cao from over-consuming the Blood. The pair achieves vigorous menstrual regulation with built-in nourishment.

When to use: Menstrual disorders with significant Blood Stasis, such as amenorrhoea, painful periods with dark clots, or postpartum Blood Stasis with lochia retention.

Du Huo
Du Huo Ji Xue Teng 15-30g : Du Huo 9-15g

Du Huo dispels Wind-Dampness and relieves pain, particularly in the lower body (lower back, knees, legs). Ji Xue Teng adds Blood nourishment and collateral-opening action. Together they treat Bi Syndrome in the lower body where Wind-Damp obstruction is combined with Blood Deficiency and Blood Stasis in the channels.

When to use: Wind-Damp Bi Syndrome affecting the lower back and legs, sciatica, or chronic arthritis with numbness and weakness in the lower limbs.

Key Formulas

These well-known formulas feature Ji Xue Teng in a prominent role

Sheng Bai Wan 升白丸 Assistant

This modern patent formula for headache combines Wind-dispelling, Blood-invigorating, and Blood-nourishing herbs. Ji Xue Teng acts as Assistant, contributing its collateral-opening and Blood-nourishing qualities alongside Chuan Xiong, Dang Gui, Tao Ren, and Hong Hua. This demonstrates Ji Xue Teng's versatility in treating pain from Blood Stasis and Wind obstruction beyond gynaecology.

Comparable Ingredients

These ingredients have overlapping uses — here's how to tell them apart

Dang Gui
Ji Xue Teng vs Dang Gui

Both tonify and invigorate Blood and are used for menstrual disorders. However, Dang Gui is the stronger Blood tonic and also moistens the Intestines (useful for dry constipation from Blood Deficiency), while Ji Xue Teng has a stronger collateral-opening and sinew-relaxing action, making it more suited for joint pain, numbness, and Bi Syndrome alongside gynaecological use. Ji Xue Teng invigorates Blood primarily and tonifies secondarily, whereas Dang Gui tonifies primarily and invigorates secondarily.

Dan Shen
Ji Xue Teng vs Dan Shen

Both invigorate Blood and are used for pain from Blood Stasis. However, Dan Shen is cool in nature and also clears Heat from the Blood and calms the spirit, making it better suited for Blood Stasis with Heat signs or Heart Blood Stasis with restlessness. Ji Xue Teng is warm and also tonifies Blood, making it better for Blood Stasis with concurrent Blood Deficiency or Cold patterns, and it has additional sinew-relaxing properties that Dan Shen lacks.

Lu Lu Tong
Ji Xue Teng vs Lu Lu Tong

Both open the channels and collaterals and invigorate Blood. Lu Lu Tong (Sweetgum fruit) focuses more on promoting the smooth flow of Qi and unblocking the channels, and is commonly used for joint pain, mastitis, and urinary difficulty. Ji Xue Teng has a much stronger Blood-tonifying action and is better suited where Blood Deficiency underlies the channel obstruction, particularly in gynaecological conditions.

Common Substitutes & Adulterants

Related species and common adulterations to be aware of when sourcing Ji Xue Teng

Ji Xue Teng has one of the most complex adulteration histories of any Chinese herb. The name "chicken blood vine" was historically applied to any vine producing red sap, leading to widespread confusion. The sole official source in the Chinese Pharmacopoeia is Spatholobus suberectus Dunn. Common substitutes and adulterants include: 1. Millettia dielsiana (香花崖豆藤, also called 丰城鸡血藤 or 山鸡血藤) - a very common substitute from a related legume genus, used particularly in Jiangxi and some southern regions. 2. Millettia reticulata (网络鸡血藤) - used in some southern localities. 3. Millettia nitida (光叶崖豆藤) - roots used as Ji Xue Teng in Guangdong and Guangxi. 4. Mucuna sempervirens (常绿油麻藤) - used in Fujian province. 5. Mucuna birdwoodiana (白花油麻藤) - stem called "blood wind vine" in Guangzhou, sometimes mixed in. 6. Sargentodoxa cuneata (大血藤, Da Xue Teng) - from a completely different family, used in northern regions (e.g. Beijing) as Ji Xue Teng. This herb has heat-clearing and toxin-resolving properties quite different from true Ji Xue Teng and lacks its Blood-nourishing action. 7. Kadsura interior (内南五味子) - from the Schisandraceae family, used in Yunnan for making "Yunnan Ji Xue Teng paste." This is a completely different plant. Authentic Spatholobus suberectus is distinguished by its characteristic cross-section showing eccentric semicircular alternating rings of wood and dark resin, and by the bright red sap when freshly cut.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herb.

Toxicity Classification

Classical Chinese pharmacopoeia toxicity rating for Ji Xue Teng

Non-toxic

Ji Xue Teng is classified as non-toxic in the Chinese Pharmacopoeia. Toxicological studies in mice showed that its tolerance dose was approximately 200 times the therapeutic dose, and the LD50 exceeded 100 g/kg by injection, indicating a very wide safety margin. No reports of toxicity or significant adverse reactions have been documented in the available Chinese medical literature at standard dosages. No special processing is required to render it safe for internal use.

Contraindications

Situations where Ji Xue Teng should not be used or requires extra caution

Avoid

Pregnancy. Ji Xue Teng activates Blood circulation and has demonstrated anti-early-pregnancy effects in pharmacological studies. Its Blood-moving properties may pose risk to the fetus.

Caution

Heavy menstrual bleeding (menorrhagia). As a Blood-invigorating herb, it may worsen excessive menstrual flow. Should only be used in menorrhagia if Blood stasis is the confirmed underlying cause and combined with appropriate hemostatic herbs.

Caution

Blood Heat with reckless bleeding (blood-heat patterns with active hemorrhage). The warm nature of this herb may aggravate heat in the Blood, potentially worsening bleeding from Heat.

Caution

Yin deficiency with internal Heat. The warm nature of Ji Xue Teng may exacerbate symptoms such as tidal fever, night sweats, and dry mouth in Yin-deficient patients.

Caution

Concurrent use with anticoagulant or antiplatelet medications without medical supervision. Pharmacological studies show Ji Xue Teng has antiplatelet activity through inhibition of the glycoprotein IIb/IIIa receptor, which may potentiate the effects of blood-thinning drugs.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. Ji Xue Teng is a Blood-activating herb with demonstrated effects on uterine tissue metabolism and circulation. Pharmacological studies have noted anti-early-pregnancy effects. Its Blood-moving and warming properties may stimulate uterine contractions, potentially leading to miscarriage or disruption of fetal development. Pregnant women should avoid this herb entirely.

Breastfeeding

No specific studies exist on the transfer of Ji Xue Teng constituents into breast milk. Given its Blood-activating properties, it should be used with caution during breastfeeding and only under practitioner guidance. The herb's isoflavonoid content (including compounds with structural similarity to phytoestrogens such as formononetin and daidzein) warrants caution regarding potential hormonal effects during lactation.

Children

Ji Xue Teng is not commonly prescribed for young children. When used in older children or adolescents (particularly for menstrual irregularities in adolescent girls), the dosage should be reduced proportionally, typically to one-third to one-half of the adult dose. There is limited specific pediatric safety data. Use in children should be guided by a qualified practitioner.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Ji Xue Teng

Anticoagulant and antiplatelet medications (e.g. warfarin, aspirin, clopidogrel): Pharmacological studies demonstrate that Ji Xue Teng has significant antiplatelet activity through inhibition of the glycoprotein IIb/IIIa receptor. Concurrent use with anticoagulant or antiplatelet drugs may increase the risk of bleeding. Patients on blood-thinning medications should consult their healthcare provider before using this herb.

Estrogen-related medications (e.g. hormone replacement therapy, oral contraceptives): Ji Xue Teng contains isoflavonoid compounds such as formononetin and daidzein, which have phytoestrogenic activity. Theoretical interaction with hormonal therapies is possible, though no specific clinical reports of adverse interactions have been documented. Caution is advised in patients with estrogen-receptor-positive cancers or those taking hormonal medications.

Dietary Advice

Foods and dietary considerations when taking Ji Xue Teng

The classical text Bencao Gangmu Shiyi specifically advises avoiding sour and cold foods (忌食酸冷) while taking Ji Xue Teng preparations. Cold and raw foods may counteract the herb's warming, Blood-activating properties. Warm, nourishing foods that support Blood production (such as red dates, dark leafy greens, and lean meats) complement its therapeutic effects.

Botanical Description

Physical characteristics and morphology of the Ji Xue Teng source plant

Spatholobus suberectus Dunn is a large, evergreen, woody climbing vine belonging to the Leguminosae (pea/bean) family. It is a vigorous climber that can grow extremely long, winding through forest canopies and over rocky terrain in tropical and subtropical forests. The stems are thick and woody, covered in greyish-brown bark with visible longitudinal grooves and scattered pale lenticels (small pores). The most distinctive feature is the bright red, blood-like sap that flows freely from the stem when it is cut, which gives the herb its Chinese name ("chicken blood vine").

The leaves are pinnately compound and alternate, typically with 7 to 9 leaflets that are ovate-elliptic or oblong, measuring 3 to 10 cm long, with nearly round bases and small stipules. Flowers are dark purple with smooth (glabrous) petals, arranged in raceme clusters, blooming from May to August. The pods are elongated and smooth, with fruits ripening from October to November. The plant thrives in warm, humid environments in southern Chinese forests, often growing along mountain slopes, valley edges, and forest margins.

Sourcing & Harvesting

Where Ji Xue Teng is sourced, when it's harvested or collected, and how to assess quality

Harvesting season

Autumn and winter (秋、冬二季). The vine stems are harvested, stripped of branches and leaves, cut into slices or sections, and sun-dried.

Primary growing regions

The primary producing regions are Guangxi (广西), Guangdong (广东), and Yunnan (云南) provinces of southern China, which are considered the authentic terroir (道地药材) areas for this herb. It is also found in Fujian province. Spatholobus suberectus grows wild in tropical and subtropical forests and has historically depended almost entirely on wild harvesting. Due to decades of unsustainable collection, high-quality wild resources within China have declined significantly, and much commercial supply now comes from neighboring Southeast Asian countries including Vietnam, Myanmar, and Laos.

Quality indicators

Good quality Ji Xue Teng drug material comes as elliptical, oblong, or irregularly shaped slices, 0.3 to 1 cm thick. The outer bark (cork layer) should be greyish-brown, sometimes with greyish-white patches, with the inner surface showing reddish-brown where the bark has fallen away. The cross-section is the key indicator: the wood portion should be reddish-brown or brown with numerous visible vessel pores, and the phloem (inner bark) should contain abundant resinous secretions that appear reddish-brown to dark brown. These resinous layers should alternate with the wood in 3 to 8 eccentric semicircular rings, which is the most characteristic identifying feature. The pith is small and offset to one side. The herb should be hard and firm in texture, with a faint smell and an astringent taste. The traditional quality maxim is: the more eccentric resin rings visible on the cut surface and the more abundant the dark resinous secretions, the better the quality.

Classical Texts

Key passages from the classical Chinese medical texts that describe Ji Xue Teng and its therapeutic uses

《本草纲目拾遗》(Bencao Gangmu Shiyi, Supplement to the Compendium of Materia Medica, Qing Dynasty, Zhao Xuemin, c. 1765)

Original: 活血,暖腰膝,已风瘫。

Translation: "Activates Blood, warms the lumbar region and knees, and resolves wind-induced paralysis."

Original: 土人得之,以刀斫断,则汁出如血,每得一茎,可得汁数升……壮筋骨,已酸痛,和酒服,于老人最宜。治老人气血虚弱,手足麻木瘫痪等症。

Translation: "When the local people find it and cut the vine with a knife, juice flows out like blood; from a single stem, several sheng [an old unit of volume] of juice can be obtained… It strengthens sinews and bones, resolves soreness and pain, and is best taken with wine. It is especially suitable for the elderly. It treats elderly persons with deficiency of Qi and Blood, numbness and paralysis of the hands and feet."


《饮片新参》(Yinpian Xincan, New Reference for Prepared Medicines)

Original: 去瘀血,生新血,流利经脉。治暑痧,风血痹症。

Translation: "Dispels stagnant Blood, generates new Blood, and frees the channels and vessels. Treats summer heat afflictions and wind-blood impediment patterns."


《现代实用中药》(Xiandai Shiyong Zhongyao, Modern Practical Chinese Medicine)

Original: 为强壮性之补血药,适用于贫血性之神经麻痹症,如肢体及腰膝酸痛,麻木不仁等。又用于妇女月经不调,月经闭止等,有活血镇痛之效。

Translation: "A tonic Blood-nourishing medicine of strengthening nature, suitable for anemic neurological numbness syndromes, such as soreness of the limbs, lower back and knees, and numbness. Also used for women's menstrual irregularities and amenorrhea, with Blood-activating and pain-relieving effects."

Historical Context

The history and evolution of Ji Xue Teng's use in Chinese medicine over the centuries

Ji Xue Teng is a relatively late entry into the Chinese medicinal canon. It was first recorded in the Qing dynasty work Bencao Beiyao (本草备要, approximately 1694 AD), and received its most detailed early description in Zhao Xuemin's Bencao Gangmu Shiyi (本草纲目拾遗, c. 1765). Notably, the great Ming dynasty physician Li Shizhen did not include it in his Bencao Gangmu, as the herb was not yet widely known in central Chinese medicine at that time.

The name Ji Xue Teng (鸡血藤, literally "chicken blood vine") comes from the vivid blood-red sap that flows when the vine stem is cut. The Bencao Gangmu Shiyi describes this dramatically: the local people would cut the vine and collect the bright red juice, which was then boiled into a concentrated paste (鸡血藤膏). This paste became a prized folk medicine in Yunnan province, especially from the Shunning Prefecture area (modern-day Fengqing County), where it was prepared annually around the Dragon Boat Festival. It was used as a major tonic for Qi and Blood, particularly valued for elderly people and women. Among the Zhuang and Yao ethnic groups of Guangxi, the red sap was symbolically regarded as the "lifeblood of the earth" and associated with natural healing power.

Historically, the identity of "Ji Xue Teng" was quite confused, as the name was applied to many different vine species across different regions of China. It was only with the 1977 edition of the Chinese Pharmacopoeia that Spatholobus suberectus Dunn was established as the sole official source species. The 饮片新参 (Yinpian Xincan) praised it as capable of "dispelling stagnant Blood and generating new Blood," and modern clinicians have come to regard it as a versatile herb that bridges the categories of Blood-nourishing and Blood-activating medicines.

Modern Research

5 published studies investigating the pharmacological effects or clinical outcomes of Ji Xue Teng

1

Comprehensive Review: Botany, Phytochemistry, Traditional Uses, Pharmacology, and Toxicology of Spatholobus suberectus Vine Stems (2023)

Huang X, Fei Q, Yu S, Liu S, Zhang L, Chen X, Cao L, Wang Z, Shan M. Journal of Ethnopharmacology, 2023, 312: 116500.

A thorough review covering the traditional uses, chemical composition, biological activities, and safety profile of Ji Xue Teng. The review identified approximately 243 chemical compounds from the herb, predominantly flavonoids, and summarized evidence for antioxidant, anti-inflammatory, anti-tumor, antiviral, and anti-diabetic activities. It noted a long safety record and highlighted the need for more clinical pharmacokinetic studies.

DOI
2

Antiplatelet Effects of Spatholobus suberectus via Inhibition of the Glycoprotein IIb/IIIa Receptor (In vitro and in vivo study, 2011)

Lee BJ, Jo IY, Bu Y, Park JW, Maeng S, Kang H, Jang W, Hwang DS, Lee MY, Kim TH. Journal of Ethnopharmacology, 2011, 133(2): 751-758.

This study demonstrated that an ethanol extract of Spatholobus suberectus showed significant antiplatelet activity in human platelet-rich plasma and in a mouse thromboembolic model. The antiplatelet effect worked primarily by inhibiting fibrinogen binding to the GP IIb/IIIa receptor, without producing anticoagulant effects. These findings provide pharmacological support for the traditional use of Ji Xue Teng in Blood stasis conditions.

PubMed
3

Spatholobus suberectus Ameliorates Diabetes-Induced Renal Damage by Suppressing Advanced Glycation End Products in db/db Mice (Preclinical study, 2018)

Do MH, Lee JH, Wahedi HM, Pak C, Lee CH, Yeo EJ, Lim Y, Ha SK, Choi I, Kim SY. Nutrients, 2018, 10(11): 1702.

This animal study in diabetic mice found that Spatholobus suberectus extract significantly reduced kidney damage associated with diabetes. The protective mechanism involved suppressing advanced glycation end products (AGEs) and activating the Nrf2/glyoxalase 1 pathway, suggesting potential renoprotective applications in diabetic complications.

PubMed
4

Spatholobus suberectus Inhibits Cancer Cell Growth by Inducing Apoptosis and Arresting Cell Cycle at G2/M Checkpoint (Preclinical study, 2011)

Wang ZY, Wang DM, Loo TY, Cheng Y, Chen LL, Shen JG, Yang DP, Chow LWC, Guan XY, Chen JP. Journal of Ethnopharmacology, 2011, 133(2): 751-758.

This in vitro and in vivo study investigated the anti-cancer effects of Spatholobus suberectus on breast cancer (MCF-7) and colon cancer (HT-29) cell lines. The extract inhibited cancer cell growth by inducing apoptosis and arresting the cell cycle at the G2/M checkpoint. In nude mouse xenograft models, tumor growth was also significantly suppressed.

PubMed
5

Spatholobus suberectus Inhibits Osteoclastogenesis and Stimulates Chondrogenesis (Preclinical study, 2014)

Ha YJ, et al. Archives of Pharmacal Research, 2014.

This laboratory study found that Spatholobus suberectus extract inhibited the expression of matrix metalloproteinases (MMPs) involved in cartilage degradation and suppressed RANKL-induced osteoclast differentiation. The results suggest the herb may have therapeutic potential for osteoarthritis and bone loss conditions, providing scientific support for its traditional use in joint pain.

PubMed

Research on individual TCM herbs is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.