Shi Zhen Fang

Eczema Formula · 湿疹方

Also known as: Lonicera & Smilax Combination, Against Eczema Formula

A modern formula designed to treat eczema and skin rashes by clearing Heat, resolving Dampness, and stopping itching. It addresses both the acute stage (red, itchy, blistered, oozing skin) and the subacute stage (dry, scabbing, flaking skin). The formula can be taken internally or used externally as a wash.

Origin Modern clinical formula (现代经验方), developed from TCM hospital practice for treating eczema and dermatitis — Modern era (contemporary clinical formula)
Composition 8 herbs
Jin Yin Hua
King
Jin Yin Hua
Tu Fu Ling
King
Tu Fu Ling
Huang Lian
Deputy
Huang Lian
Ju Hua
Deputy
Ju Hua
Yi Yi Ren
Assistant
Yi Yi Ren
Fang Feng
Assistant
Fang Feng
Chan Tui
Assistant
Chan Tui
Gan Cao
Envoy
Gan Cao
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Shi Zhen Fang is designed to correct these specific patterns.

Why Shi Zhen Fang addresses this pattern

This is the primary pattern Shi Zhen Fang addresses. When external Wind-Heat combines with internal Dampness and lodges in the skin, it produces red, hot, itchy rashes that may blister and ooze. The Wind component causes itching and the tendency of lesions to shift locations. The Heat component causes redness, burning, and inflammation. The Dampness component causes oozing, blistering, and a sticky quality to the lesions. Shi Zhen Fang targets all three factors: Jin Yin Hua, Huang Lian, and Ju Hua clear Heat and toxins; Tu Fu Ling and Yi Yi Ren resolve Dampness; Fang Feng and Chan Tui disperse Wind and stop itching. This multi-pronged approach makes it particularly suited for acute and subacute eczema where all three pathogenic factors are present.

A practitioner would look for one or more of these signs

Skin Rashes

Red, inflamed skin rash with burning sensation

Twitching

Intense itching that worsens with heat

Skin Blisters

Small blisters or vesicles on skin, may ooze when broken

Skin Erosion

Erosion and weeping of skin in acute stage

Dark Skin

Dryness, scabbing, and flaking in subacute stage

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Shi Zhen Fang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM understands eczema (called "shi chuang" or "shi zhen" in Chinese, meaning "damp sore" or "damp rash") as arising from the interplay of internal and external factors. Internally, weakness of the Spleen leads to accumulation of Dampness, which can transform into Heat over time. Externally, Wind, Heat, and Dampness invade the skin. When internal Dampness meets external pathogenic factors, they combine and lodge in the skin, blocking the smooth flow of Qi and fluids in the superficial tissues. The resulting stagnation produces the characteristic eczema symptoms: redness (Heat), oozing and blistering (Dampness), itching (Wind), and the tendency to recur (lingering Dampness is hard to clear). The Spleen, Lung, and Liver organ systems are most closely involved, as the Spleen governs Dampness metabolism, the Lung governs the skin, and the Liver relates to Wind and emotional stress that can trigger flares.

Why Shi Zhen Fang Helps

Shi Zhen Fang directly addresses the core pathogenic triad of Wind, Dampness, and Heat that drives eczema. Jin Yin Hua and Huang Lian clear the Heat-toxin responsible for redness and inflammation. Tu Fu Ling, a herb with a long history of treating toxic Damp-Heat skin conditions, works with Yi Yi Ren to drain Dampness through the urine and support Spleen function, tackling the Dampness that causes oozing and blistering. Fang Feng and Chan Tui disperse Wind to stop the itching that is often the most distressing symptom. Ju Hua adds gentle Wind-Heat clearing. The formula is particularly well suited for acute and subacute eczema where all three pathogenic factors are active, and can be used both internally and externally as a wash for affected areas.

Also commonly used for

Urticaria

Hives with red, hot, itchy wheals, especially Wind-Heat type

Skin Rashes

Various allergic skin rashes with inflammation and oozing

Twitching

Generalized or localized pruritus associated with skin inflammation

What This Formula Does

Every TCM formula has a specific set of actions — here's what Shi Zhen Fang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Shi Zhen Fang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Shi Zhen Fang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Shi Zhen Fang works at the root level.

Eczema, known in TCM as Shi Zhen (湿疹, "damp eruption"), arises from a combination of internal and external pathogenic factors converging on the skin. The core disease mechanism involves Wind, Dampness, and Heat becoming entangled in the skin and flesh layer (肌肤).

Externally, Wind-Heat invades through the skin's surface, while Dampness (from environmental exposure or internal accumulation due to Spleen weakness) becomes trapped in the tissue. When Wind, Dampness, and Heat combine, they create the characteristic presentation: redness and burning (Heat), weeping and blistering (Dampness), and itching that moves or spreads (Wind). The itching itself is a hallmark of Wind, while the oozing, erosion, and "sticky" quality of the lesions reflect Dampness accumulating beneath the skin. Heat drives the inflammation, causing redness and a burning sensation.

In the acute and subacute stages, Damp-Heat predominates. The Dampness is heavy and turbid, tending to linger and making the condition stubborn and prone to relapse. Because Wind carries the other pathogens to the skin surface and causes them to spread, the rash can appear suddenly and migrate to different areas. This formula targets precisely this acute Damp-Heat with Wind pattern, addressing all three pathogenic factors simultaneously rather than treating any one in isolation.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter and sweet with a bland undertone. Bitter to clear Heat and dry Dampness, sweet to moderate the formula and harmonize the Stomach, bland to drain Dampness through urination.

Ingredients

8 herbs

The herbs that make up Shi Zhen Fang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Jin Yin Hua

Jin Yin Hua

Honeysuckle flowers

Dosage 9 - 15g
Temperature Cold
Taste Sweet
Organ Affinity Heart, Lungs, Stomach

Role in Shi Zhen Fang

Clears Heat and resolves toxins from the skin. As the primary herb, it targets the Heat-toxin component driving skin inflammation, redness, and burning sensations. Its broad-spectrum Heat-clearing action addresses the root cause of acute eczema flare-ups.
Tu Fu Ling

Tu Fu Ling

Smilax glabra roots

Dosage 15 - 30g
Temperature Neutral
Taste Sweet
Organ Affinity Liver, Stomach

Role in Shi Zhen Fang

Clears Heat, resolves toxins, and eliminates Dampness. It works in tandem with Jin Yin Hua to address both the Heat and Dampness that underlie eczema, and has a particular affinity for resolving Damp-Heat skin lesions with oozing and erosion.
Deputies — Assists and enhances the King
Huang Lian

Huang Lian

Goldthread rhizomes

Dosage 3 - 6g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Large Intestine, Liver, Spleen, Stomach

Role in Shi Zhen Fang

Strongly clears Heat and dries Dampness. Its bitter, cold nature powerfully drains Damp-Heat from the Middle Burner and skin, helping to reduce inflammation, redness, and oozing in eczema. It reinforces the Heat-clearing action of the King herbs.
Ju Hua

Ju Hua

Chrysanthemum flowers

Dosage 9 - 12g
Temperature Cool
Taste Bitter, Sweet
Organ Affinity Liver, Lungs

Role in Shi Zhen Fang

Disperses Wind-Heat from the upper body and skin surface, clears Heat and detoxifies. It supports the King herbs by helping to vent exterior Wind-Heat, addressing the itching and superficial redness of eczema.
Assistants — Supports or moderates other herbs
Yi Yi Ren

Yi Yi Ren

Job's tears

Dosage 15 - 30g
Temperature Cool
Taste Sweet
Organ Affinity Lungs, Spleen, Stomach

Role in Shi Zhen Fang

Strengthens the Spleen and drains Dampness through the urine. By promoting the elimination of Dampness from below and supporting Spleen function, it addresses the underlying tendency for fluid accumulation that manifests as oozing, blistering skin lesions.
Fang Feng

Fang Feng

Saposhnikovia roots

Dosage 6 - 9g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Urinary Bladder, Liver, Spleen

Role in Shi Zhen Fang

Expels Wind and stops itching. Wind is the classical pathogenic factor most associated with itching and the migratory, relapsing nature of eczema rashes. Fang Feng disperses Wind from the skin surface and helps relieve the intense pruritus.
Chan Tui

Chan Tui

Cicada sloughs

Dosage 3 - 6g
Temperature Cold
Taste Bitter, Salty
Organ Affinity Liver, Lungs

Role in Shi Zhen Fang

Disperses Wind and stops itching, vents rashes to the surface. Chan Tui is a key anti-itch herb that specifically targets Wind-Heat skin conditions. It works synergistically with Fang Feng to address itching from a different angle, helping to vent pathogenic factors outward through the skin.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Liquorice

Dosage 3 - 6g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Shi Zhen Fang

Harmonizes all the other herbs in the formula, moderates the cold and bitter nature of the Heat-clearing herbs to protect the Stomach, and adds mild Heat-clearing and detoxifying action of its own.

Why This Combination Works

How the herbs in Shi Zhen Fang complement each other

Overall strategy

Eczema in TCM arises when Wind, Dampness, and Heat combine to invade the skin, causing itching, redness, oozing, and blistering. Shi Zhen Fang simultaneously clears Heat-toxins, transforms Dampness, and expels Wind to address all three pathogenic factors in a single formula.

King herbs

Jin Yin Hua and Tu Fu Ling form a powerful dual-King pair. Jin Yin Hua is one of the most important Heat-clearing and toxin-resolving herbs in the materia medica, targeting the inflammatory Heat-toxin that drives skin redness and burning. Tu Fu Ling complements it by specializing in resolving Damp-Heat from the skin and joints, with a long history of treating toxic skin conditions. Together they attack the two primary pathogenic factors, Heat and Dampness, from the core.

Deputy herbs

Huang Lian reinforces the Heat-clearing strategy with its intensely bitter, cold nature that powerfully dries Dampness and drains Fire, especially from the Heart and Stomach channels, which relate closely to skin conditions in TCM theory. Ju Hua adds a lighter, dispersing quality that helps to vent Wind-Heat from the superficial layers of the body, addressing itching and exterior signs.

Assistant herbs

Yi Yi Ren acts as a reinforcing Assistant by draining Dampness downward through the urine while supporting the Spleen, addressing the root tendency toward Dampness accumulation. Fang Feng and Chan Tui are both Wind-dispersing Assistants with strong anti-itch effects. Fang Feng is considered the "commander of all Wind-expelling herbs" and has a broad anti-allergic reputation in TCM dermatology. Chan Tui specifically vents Heat rashes outward and is prized for its targeted action on itching skin conditions.

Envoy herbs

Gan Cao harmonizes the formula, protecting the digestive system from the cold, bitter herbs while adding its own mild detoxifying properties. It helps direct the other herbs to work smoothly together.

Notable synergies

Jin Yin Hua paired with Huang Lian creates a strong Heat-clearing and Damp-drying combination that targets the inflammatory core of eczema. Fang Feng combined with Chan Tui provides comprehensive Wind-dispersing and itch-relieving action that covers both superficial and deeper levels of pathogenic Wind. Tu Fu Ling and Yi Yi Ren together establish a thorough Dampness-resolving axis, with Tu Fu Ling clearing toxic Dampness and Yi Yi Ren draining bland Dampness through the Spleen and urinary system.

How to Prepare

Traditional preparation instructions for Shi Zhen Fang

As a granule extract, mix 4.5g of granules in hot water and drink as a tea, 2 to 3 times daily. The formula can also be prepared as a traditional decoction: combine all herbs with approximately 600ml of water, bring to a boil, then simmer on low heat for 20 to 30 minutes. Strain and divide into two portions, taken warm morning and evening. For external use, the decoction can be cooled and applied as a wash or compress to affected skin areas.

Common Modifications

How practitioners adapt Shi Zhen Fang for specific situations

Added
Bai Xian Pi

15g, strongly clears Damp-Heat and stops itching

Di Fu Zi

9 - 15g, clears Heat and relieves itching from Dampness

Bai Xian Pi and Di Fu Zi are two of the most effective Damp-Heat itch-stopping herbs in TCM dermatology. Adding them significantly strengthens the anti-pruritic action when standard Wind-dispersing herbs are insufficient.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Shi Zhen Fang should not be used or requires extra caution

Caution

Not suitable for chronic eczema presenting with Blood Deficiency and Wind-Dryness pattern (dry, thickened, scaly skin without redness or weeping). This formula's cooling and Dampness-draining nature would further deplete Blood and Yin fluids, worsening dryness. A formula like Dang Gui Yin Zi would be more appropriate.

Caution

Use with caution in individuals with Spleen and Stomach deficiency Cold (poor appetite, loose stools, cold abdomen). The formula contains several cold and bitter herbs (Huang Lian, Ju Hua) that can further injure the middle burner. If used, consider adding Spleen-supporting herbs.

Caution

Not appropriate for skin conditions caused purely by external Wind-Cold without Heat or Dampness signs. The formula is designed for Wind-Heat and Damp-Heat patterns and would be ineffective or counterproductive for Cold-type presentations.

Caution

Use with caution in individuals with liver disease, as several herbs in the formula undergo hepatic metabolism. Liver function should be monitored during extended use.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Huang Lian (Coptis Rhizome) is very bitter and cold, and while not strictly contraindicated, its strong cold nature may be too harsh during pregnancy, particularly in the first trimester. Chan Tui (Cicada Slough) is generally considered safe in pregnancy but should still be used judiciously. Yi Yi Ren (Coix Seed) is traditionally noted as having a mild downward-directing quality that some classical sources advise against during pregnancy, though this concern applies mainly to raw (uncooked) Yi Yi Ren at high doses. Overall, this formula should only be used during pregnancy under the guidance of a qualified practitioner, and only when the clinical need is clear.

Breastfeeding

Use with caution during breastfeeding. Huang Lian (Coptis Rhizome) contains berberine, which can transfer into breast milk. While the amounts in a standard herbal formula are generally small, berberine has been reported to potentially cause jaundice in newborns in rare cases. The other herbs in the formula are generally considered low-risk during breastfeeding, but as a precaution, nursing mothers should consult a qualified practitioner before use, especially if the infant is very young (under 3 months).

Children

Eczema is extremely common in children, and this formula may be considered for pediatric use under professional guidance. Dosage should be reduced according to the child's age and body weight: roughly one-third of the adult dose for children aged 3 to 6, and one-half for children aged 6 to 12. For very young children (under 3), the formula should only be used with explicit practitioner supervision, with further dose reduction. The bitter and cold nature of Huang Lian may be difficult for children to tolerate, and the taste can be masked by adding a small amount of honey (for children over 1 year old) or mixing with a palatable liquid. External application as a wash or compress may be better tolerated than oral administration in very young children.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Shi Zhen Fang

Huang Lian (Coptis Rhizome) and berberine-containing interactions: Berberine, a major alkaloid in Huang Lian, can inhibit certain cytochrome P450 enzymes (especially CYP3A4 and CYP2D6) and may increase the blood levels and effects of drugs metabolized through these pathways. This is particularly relevant for cyclosporine, statins, and certain antihistamines. Berberine may also enhance the blood sugar-lowering effects of metformin and other diabetes medications, potentially causing hypoglycemia.

Gan Cao (Licorice Root): Glycyrrhizin in licorice can cause sodium retention and potassium loss, potentially interacting with diuretics, corticosteroids (including topical steroids commonly used for eczema), cardiac glycosides (digoxin), and antihypertensive medications. In an eczema formula often used alongside topical corticosteroids, this interaction deserves particular attention.

Anticoagulant and antiplatelet interactions: Some herbs in the formula have mild blood-activating properties that could theoretically enhance the effects of warfarin, aspirin, or other blood thinners, though this risk is low at standard doses.

Usage Guidance

Practical advice for getting the most out of Shi Zhen Fang

Best time to take

30 minutes after meals, 2 to 3 times daily, to reduce potential stomach discomfort from the bitter and cold herbs.

Typical duration

Acute flares: 1 to 2 weeks; subacute eczema: 2 to 4 weeks, then reassess. Not intended for continuous long-term use without practitioner review.

Dietary advice

While taking this formula, avoid foods that generate Dampness and Heat: greasy or deep-fried foods, alcohol, spicy foods (chili, pepper, raw garlic), shellfish, shrimp, and crab (which are considered "hair-trigger" or fa wu foods in TCM that can aggravate skin conditions). Also avoid overly sweet or rich foods that burden the Spleen and generate internal Dampness. Favor light, easily digestible foods that support Spleen function and help drain Dampness: plain rice or rice porridge, mung beans, winter melon, cucumber, barley water (Yi Yi Ren), celery, and leafy greens. Adequate water intake supports the Dampness-draining function of the formula.

Shi Zhen Fang originates from Modern clinical formula (现代经验方), developed from TCM hospital practice for treating eczema and dermatitis Modern era (contemporary clinical formula)

Classical Texts

Key passages from the classical Chinese medical texts that first described Shi Zhen Fang and its clinical use

This is a modern empirical formula (经验方) rather than a classical prescription, so no passages from the traditional canon directly describe it. However, the formula's design draws on fundamental TCM dermatology principles:

The classical concept of eczema as "Shi Zhen" (湿疹, literally "damp eruption") reflects the understanding that this condition arises from Dampness interacting with Wind and Heat. The Wai Ke Zheng Zong (《外科正宗》) by Chen Shigong (陈实功), a foundational Ming Dynasty text on external medicine, established core treatment principles for skin diseases involving clearing Heat, resolving Dampness, and dispelling Wind that this formula follows.

The classical teaching "治湿不利小便非其治也" ("treating Dampness without promoting urination is not the correct treatment") underpins the inclusion of Dampness-draining herbs like Yi Yi Ren (Coix Seed) in this formula.

Historical Context

How Shi Zhen Fang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Shi Zhen Fang (湿疹方, "Eczema Formula") is a modern empirical formula rather than a classical prescription from a specific historical text. It was developed based on well-established TCM dermatology principles for treating Damp-Heat skin conditions, and has been adopted by several herbal product manufacturers, including Tianjiang Pharmaceutical (天江药业), as a standardized formula for clinical use in TCM hospitals.

The formula draws on a long tradition of treating "Shi Zhen" (湿疹) in Chinese medicine. Classical dermatology texts like Chen Shigong's Wai Ke Zheng Zong (《外科正宗》, 1617) and later works established the framework of clearing Heat, draining Dampness, and dispelling Wind for oozing, itchy skin eruptions. Separately, Prof. Zhi-Xiu Lin at the Chinese University of Hong Kong developed a related but distinct nine-herb Shi Zhen Formula that has been the subject of published pharmacological research into atopic dermatitis, demonstrating anti-inflammatory and skin barrier-restoring effects in preclinical models.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Shi Zhen Fang

1

Efficacy and action mechanisms of a Chinese herbal formula on experimental models of atopic dermatitis (Preclinical study, 2021)

Wang L, Xian YF, Hu Z, Loo SKF, Ip SP, Chan WY, Lin ZX, Wu JCY. Journal of Ethnopharmacology, 2021, 274:114021.

This preclinical study investigated a Shi Zhen Formula (SZF) in mouse models of atopic dermatitis. The formula significantly reduced epidermal thickening, mast cell infiltration, and serum IgE and histamine levels. It suppressed Th2 cytokines (IL-4, IL-13, IL-31), restored skin barrier proteins (filaggrin, involucrin, loricrin), and inhibited the NF-kB inflammatory signaling pathway. The researchers concluded that SZF alleviates atopic dermatitis-like lesions by rebalancing Th1/Th2 immunity, improving the skin barrier, and reducing inflammation.

DOI
2

Systems Pharmacology and In Silico Docking Analysis Uncover Association of CA2, PPARG, RXRA, and VDR with the Mechanisms Underlying the Shi Zhen Tea Formula Effect on Eczema (Network pharmacology study, 2021)

Wang ZZ, Li Y, Huang W, Tiwari R, Wu AN, Gong J, Marella M, Shi K, Li XM. Evidence-Based Complementary and Alternative Medicine, 2021, Article 6626728.

This network pharmacology study analyzed the active compounds and molecular targets of a Shi Zhen Tea formula for eczema. Researchers identified 51 active compounds interacting with 81 potential eczema-related targets across 327 interactions, suggesting the formula works through multiple pathways including anti-inflammatory, immune-modulatory, and skin barrier repair mechanisms.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.