Formula

Shi Zhen Fang

Lonicera & Smilax Combination | 湿疹方

Also known as:

Eczema formula , Against Eczema formula

Properties

Heat-clearing formulas · Cool

Key Ingredients

Jin Yin Hua, Tu Fu Ling

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A modern formula designed to treat eczema and skin rashes by clearing Heat, resolving Dampness, and stopping itching. It addresses both the acute stage (red, itchy, blistered, oozing skin) and the subacute stage (dry, scabbing, flaking skin). The formula can be taken internally or used externally as a wash.

Formula Category

Main Actions

  • Clears Heat and Drains Dampness
  • Dispels Wind and Stops Itching
  • Clears Heat-Toxin from the Skin
  • Resolves Dampness from the Skin

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Shi Zhen Fang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Shi Zhen Fang addresses this pattern

This is the primary pattern Shi Zhen Fang addresses. When external Wind-Heat combines with internal Dampness and lodges in the skin, it produces red, hot, itchy rashes that may blister and ooze. The Wind component causes itching and the tendency of lesions to shift locations. The Heat component causes redness, burning, and inflammation. The Dampness component causes oozing, blistering, and a sticky quality to the lesions. Shi Zhen Fang targets all three factors: Jin Yin Hua, Huang Lian, and Ju Hua clear Heat and toxins; Tu Fu Ling and Yi Yi Ren resolve Dampness; Fang Feng and Chan Tui disperse Wind and stop itching. This multi-pronged approach makes it particularly suited for acute and subacute eczema where all three pathogenic factors are present.

A practitioner would look for one or more of these signs

Skin Rashes

Red, inflamed skin rash with burning sensation

Twitching

Intense itching that worsens with heat

Skin Blisters

Small blisters or vesicles on skin, may ooze when broken

Skin Erosion

Erosion and weeping of skin in acute stage

Dark Skin

Dryness, scabbing, and flaking in subacute stage

How It Addresses the Root Cause

Eczema, known in TCM as Shi Zhen (湿疹, "damp eruption"), arises from a combination of internal and external pathogenic factors converging on the skin. The core disease mechanism involves Wind, Dampness, and Heat becoming entangled in the skin and flesh layer (肌肤).

Externally, Wind-Heat invades through the skin's surface, while Dampness (from environmental exposure or internal accumulation due to Spleen weakness) becomes trapped in the tissue. When Wind, Dampness, and Heat combine, they create the characteristic presentation: redness and burning (Heat), weeping and blistering (Dampness), and itching that moves or spreads (Wind). The itching itself is a hallmark of Wind, while the oozing, erosion, and "sticky" quality of the lesions reflect Dampness accumulating beneath the skin. Heat drives the inflammation, causing redness and a burning sensation.

In the acute and subacute stages, Damp-Heat predominates. The Dampness is heavy and turbid, tending to linger and making the condition stubborn and prone to relapse. Because Wind carries the other pathogens to the skin surface and causes them to spread, the rash can appear suddenly and migrate to different areas. This formula targets precisely this acute Damp-Heat with Wind pattern, addressing all three pathogenic factors simultaneously rather than treating any one in isolation.

Formula Properties

Temperature

Cool

Taste Profile

Predominantly bitter and sweet with a bland undertone. Bitter to clear Heat and dry Dampness, sweet to moderate the formula and harmonize the Stomach, bland to drain Dampness through urination.

Target Organs
Lungs Spleen Liver Stomach Large Intestine
Channels Entered
Lung Spleen Stomach Liver Large Intestine

Formula Origin

Modern clinical formula (现代经验方), developed from TCM hospital practice for treating eczema and dermatitis

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Shi Zhen Fang

Detailed information about each herb in Shi Zhen Fang and their roles

Kings
Deputies
Assistants
Envoys
Jin Yin Hua
Jin Yin Hua

Honeysuckle flower

Dosage: 9 - 15g

Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Lungs, Heart, Stomach, Large Intestine
Parts Used Flower bud (花蕾 huā lěi)
Role in Shi Zhen Fang

Clears Heat and resolves toxins from the skin. As the primary herb, it targets the Heat-toxin component driving skin inflammation, redness, and burning sensations. Its broad-spectrum Heat-clearing action addresses the root cause of acute eczema flare-ups.

Tu Fu Ling
Tu Fu Ling

Glabrous greenbrier rhizome

Dosage: 15 - 30g

Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Liver, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Shi Zhen Fang

Clears Heat, resolves toxins, and eliminates Dampness. It works in tandem with Jin Yin Hua to address both the Heat and Dampness that underlie eczema, and has a particular affinity for resolving Damp-Heat skin lesions with oozing and erosion.

Huang Lian
Huang Lian

Coptis rhizome

Dosage: 3 - 6g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen
Parts Used Rhizome (根茎 gēn jīng)
Role in Shi Zhen Fang

Strongly clears Heat and dries Dampness. Its bitter, cold nature powerfully drains Damp-Heat from the Middle Burner and skin, helping to reduce inflammation, redness, and oozing in eczema. It reinforces the Heat-clearing action of the King herbs.

Ju Hua
Ju Hua

Chrysanthemum flower

Dosage: 9 - 12g

Temperature Slightly Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Liver
Parts Used Flower (花 huā)
Role in Shi Zhen Fang

Disperses Wind-Heat from the upper body and skin surface, clears Heat and detoxifies. It supports the King herbs by helping to vent exterior Wind-Heat, addressing the itching and superficial redness of eczema.

Yi Yi Ren
Yi Yi Ren

Job's Tears seed

Dosage: 15 - 30g

Temperature Cool
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Spleen, Stomach, Lungs
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in Shi Zhen Fang

Strengthens the Spleen and drains Dampness through the urine. By promoting the elimination of Dampness from below and supporting Spleen function, it addresses the underlying tendency for fluid accumulation that manifests as oozing, blistering skin lesions.

Fang Feng
Fang Feng

Siler root

Dosage: 6 - 9g

Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Urinary Bladder, Liver, Spleen
Parts Used Root (根 gēn)
Role in Shi Zhen Fang

Expels Wind and stops itching. Wind is the classical pathogenic factor most associated with itching and the migratory, relapsing nature of eczema rashes. Fang Feng disperses Wind from the skin surface and helps relieve the intense pruritus.

Chan Tui
Chan Tui

Cicada Slough

Dosage: 3 - 6g

Temperature Cold
Taste Sweet (甘 gān), Salty (咸 xián)
Organ Affinity Lungs, Liver
Parts Used Shell (壳 ké / 甲 jiǎ)
Role in Shi Zhen Fang

Disperses Wind and stops itching, vents rashes to the surface. Chan Tui is a key anti-itch herb that specifically targets Wind-Heat skin conditions. It works synergistically with Fang Feng to address itching from a different angle, helping to vent pathogenic factors outward through the skin.

Gan Cao
Gan Cao

Licorice root

Dosage: 3 - 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Shi Zhen Fang

Harmonizes all the other herbs in the formula, moderates the cold and bitter nature of the Heat-clearing herbs to protect the Stomach, and adds mild Heat-clearing and detoxifying action of its own.

Modern Research (2 studies)

  • Efficacy and action mechanisms of a Chinese herbal formula on experimental models of atopic dermatitis (Preclinical study, 2021)
  • Systems Pharmacology and In Silico Docking Analysis Uncover Association of CA2, PPARG, RXRA, and VDR with the Mechanisms Underlying the Shi Zhen Tea Formula Effect on Eczema (Network pharmacology study, 2021)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

30 minutes after meals, 2 to 3 times daily, to reduce potential stomach discomfort from the bitter and cold herbs.

Typical Duration

Acute flares: 1 to 2 weeks; subacute eczema: 2 to 4 weeks, then reassess. Not intended for continuous long-term use without practitioner review.

Dietary Advice

While taking this formula, avoid foods that generate Dampness and Heat: greasy or deep-fried foods, alcohol, spicy foods (chili, pepper, raw garlic), shellfish, shrimp, and crab (which are considered "hair-trigger" or fa wu foods in TCM that can aggravate skin conditions). Also avoid overly sweet or rich foods that burden the Spleen and generate internal Dampness. Favor light, easily digestible foods that support Spleen function and help drain Dampness: plain rice or rice porridge, mung beans, winter melon, cucumber, barley water (Yi Yi Ren), celery, and leafy greens. Adequate water intake supports the Dampness-draining function of the formula.

Modern Usage

This formula is used to address patterns such as Wind-Dampness, which causes eczema. It manifests as skin rash, burning sensation, itching, blisters, and skin erosion in the acute stage, and dryness, scabbing, and flaking in the subacute stage. It can be used both internally and externally.

Special Populations

Pregnancy

Use with caution during pregnancy. Huang Lian (Coptis Rhizome) is very bitter and cold, and while not strictly contraindicated, its strong cold nature may be too harsh during pregnancy, particularly in the first trimester. Chan Tui (Cicada Slough) is generally considered safe in pregnancy but should still be used judiciously. Yi Yi Ren (Coix Seed) is traditionally noted as having a mild downward-directing quality that some classical sources advise against during pregnancy, though this concern applies mainly to raw (uncooked) Yi Yi Ren at high doses. Overall, this formula should only be used during pregnancy under the guidance of a qualified practitioner, and only when the clinical need is clear.

Breastfeeding

Use with caution during breastfeeding. Huang Lian (Coptis Rhizome) contains berberine, which can transfer into breast milk. While the amounts in a standard herbal formula are generally small, berberine has been reported to potentially cause jaundice in newborns in rare cases. The other herbs in the formula are generally considered low-risk during breastfeeding, but as a precaution, nursing mothers should consult a qualified practitioner before use, especially if the infant is very young (under 3 months).

Pediatric Use

Eczema is extremely common in children, and this formula may be considered for pediatric use under professional guidance. Dosage should be reduced according to the child's age and body weight: roughly one-third of the adult dose for children aged 3 to 6, and one-half for children aged 6 to 12. For very young children (under 3), the formula should only be used with explicit practitioner supervision, with further dose reduction. The bitter and cold nature of Huang Lian may be difficult for children to tolerate, and the taste can be masked by adding a small amount of honey (for children over 1 year old) or mixing with a palatable liquid. External application as a wash or compress may be better tolerated than oral administration in very young children.

Drug Interactions

Huang Lian (Coptis Rhizome) and berberine-containing interactions: Berberine, a major alkaloid in Huang Lian, can inhibit certain cytochrome P450 enzymes (especially CYP3A4 and CYP2D6) and may increase the blood levels and effects of drugs metabolized through these pathways. This is particularly relevant for cyclosporine, statins, and certain antihistamines. Berberine may also enhance the blood sugar-lowering effects of metformin and other diabetes medications, potentially causing hypoglycemia.

Gan Cao (Licorice Root): Glycyrrhizin in licorice can cause sodium retention and potassium loss, potentially interacting with diuretics, corticosteroids (including topical steroids commonly used for eczema), cardiac glycosides (digoxin), and antihypertensive medications. In an eczema formula often used alongside topical corticosteroids, this interaction deserves particular attention.

Anticoagulant and antiplatelet interactions: Some herbs in the formula have mild blood-activating properties that could theoretically enhance the effects of warfarin, aspirin, or other blood thinners, though this risk is low at standard doses.

Contraindications

Caution

Not suitable for chronic eczema presenting with Blood Deficiency and Wind-Dryness pattern (dry, thickened, scaly skin without redness or weeping). This formula's cooling and Dampness-draining nature would further deplete Blood and Yin fluids, worsening dryness. A formula like Dang Gui Yin Zi would be more appropriate.

Caution

Use with caution in individuals with Spleen and Stomach deficiency Cold (poor appetite, loose stools, cold abdomen). The formula contains several cold and bitter herbs (Huang Lian, Ju Hua) that can further injure the middle burner. If used, consider adding Spleen-supporting herbs.

Caution

Not appropriate for skin conditions caused purely by external Wind-Cold without Heat or Dampness signs. The formula is designed for Wind-Heat and Damp-Heat patterns and would be ineffective or counterproductive for Cold-type presentations.

Caution

Use with caution in individuals with liver disease, as several herbs in the formula undergo hepatic metabolism. Liver function should be monitored during extended use.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Treasure of the East

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