Shi Wei Bai Du San

Ten-Ingredient Powder to Overcome Toxicity · 十味敗毒散

Also known as: Bupleurum and Schizonepeta Formula, Shi Wei Bai Du Tang, Jūmi-Haidoku-San (Japanese reading),

A ten-herb formula originally developed in Japan for treating the early stages of skin infections, boils, and abscesses. It is now widely used for a range of inflammatory skin conditions including acne, eczema, and hives, working by dispelling Wind and Dampness from the skin while clearing Heat and toxins from the body.

Origin Experiential formula (經驗方) by Hanaoka Seishū (華岡青洲), Edo period Japan — Edo period, Japan, c. 1760–1835 CE
Composition 10 herbs
Jing Jie
King
Jing Jie
Fang Feng
King
Fang Feng
Chai Hu
Deputy
Chai Hu
Du Huo
Deputy
Du Huo
Chuan Xiong
Assistant
Chuan Xiong
Jie Geng
Assistant
Jie Geng
Fu Ling
Assistant
Fu Ling
Ying Pi
Assistant
Ying Pi
+2
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Shi Wei Bai Du San is designed to correct these specific patterns.

Why Shi Wei Bai Du San addresses this pattern

When Heat-toxin accumulates in the skin and flesh, it produces painful, red, swollen lesions such as boils, carbuncles, and abscesses, especially in their initial stages before suppuration is complete. Shi Wei Bai Du San addresses this by using Jing Jie and Fang Feng to vent Heat from the exterior, Chai Hu to clear Heat from the Shao Yang level, and Ying Pi (cherry bark) to directly clear Heat-toxin from the skin. Jie Geng and Chuan Xiong work together to expel pus and resolve the local toxic accumulation. Gan Cao further assists in resolving toxicity. This formula is best suited for cases where the toxin has not yet fully suppurated and is still in its early, inflammatory stage.

A practitioner would look for one or more of these signs

Boils

Red, painful, swollen skin lesions in early stages

Skin Abscess

Localized hot, painful swellings with pus formation

Carbuncles

Deep, painful inflammatory skin nodules

Fever

Mild fever or aversion to wind and cold accompanying skin lesions

Red Eyes

Redness of the eyes accompanying toxic Heat

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Shi Wei Bai Du San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, acne is understood as a condition where Heat and Dampness accumulate in the skin, often influenced by the Lung (which governs the skin), the Spleen (which processes Dampness), and the Liver (which can generate Heat when Qi becomes stagnant). In adolescents and young adults, constitutional Heat in the Blood can drive toxins to the face and upper body. When Dampness from poor Spleen function combines with this Heat, it creates the sticky, pus-filled lesions typical of cystic acne. The Liver's role is particularly relevant because emotional stress or hormonal fluctuations can cause Liver Qi to stagnate and transform into Heat, worsening breakouts.

Why Shi Wei Bai Du San Helps

Shi Wei Bai Du San approaches acne through multiple channels. Jing Jie and Fang Feng release Wind-Heat from the skin surface and are classical herbs for clearing skin eruptions. Chai Hu spreads Liver Qi and clears Heat from the Shao Yang level, directly addressing the Liver Heat and stagnation component. Chuan Xiong invigorates Blood to help resolve the local stagnation that forms painful nodules, while Jie Geng lifts and directs toxins outward for expulsion. Fu Ling drains underlying Dampness that feeds the formation of pustules. Ying Pi (cherry bark) provides additional Heat-toxin clearing action targeted at the skin. This multi-pronged approach makes the formula especially suitable for inflammatory and cystic acne with a mixed presentation of Heat, Dampness, and toxin accumulation.

Also commonly used for

Boils

Early-stage boils before full suppuration

Carbuncles

Initial stage with redness, heat, swelling, and pain

Skin Abscess

Superficial abscesses in early inflammatory stage

Seborrheic Dermatitis

Oily, red, flaking skin conditions

Mastitis

Early-stage breast abscess with inflammation

Otitis Media

Acute middle ear inflammation

Styes

Acute eyelid abscess

Lymphadenitis

Swollen, inflamed lymph nodes

Cysts

Inflamed subcutaneous cysts

What This Formula Does

Every TCM formula has a specific set of actions — here's what Shi Wei Bai Du San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Shi Wei Bai Du San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Shi Wei Bai Du San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Shi Wei Bai Du San works at the root level.

Shi Wei Bai Du San addresses a pattern where Wind, Dampness, and Toxic Heat converge in the skin and superficial tissues. In TCM, the skin is governed by the Lungs (which control the body's outer defense) and nourished by the Spleen (which manages fluid metabolism). When external Wind and Dampness invade and become trapped in the skin layers, they can generate localized Heat. This Heat intensifies and becomes toxic (what TCM calls "Fire Poison"), producing the characteristic signs of skin inflammation: redness, swelling, pain, and eventually pus formation.

The pathological sequence typically begins with Wind carrying Dampness into the body's exterior. Dampness, being heavy and sticky, tends to linger and obstruct the flow of Qi and Blood in the superficial tissues. Stagnation generates Heat, and as the Heat intensifies, it "cooks" the fluids and flesh, leading to suppuration. This mechanism explains conditions like boils, carbuncles, acne, and early-stage abscesses, as well as inflammatory skin conditions like eczema, urticaria, and dermatitis where Wind-Dampness-Heat interplay is prominent.

The formula intervenes by simultaneously opening the body's exterior (releasing Wind), resolving Dampness, clearing Toxic Heat, and invigorating Blood flow to the affected area. By addressing all three pathogenic factors at once rather than just one, it can break the cycle of stagnation and toxin accumulation that drives the skin disease.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly pungent and bitter, with a mild sweet undertone. The pungent taste disperses Wind and opens the exterior, while the bitter taste clears Heat and dries Dampness.

Channels Entered

Lung Spleen Liver Bladder

Ingredients

10 herbs

The herbs that make up Shi Wei Bai Du San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Jing Jie

Jing Jie

Schizonepeta herb

Dosage 1.5 - 3g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Lungs, Liver

Role in Shi Wei Bai Du San

Releases the exterior, dispels Wind from the skin surface, and vents rashes. Strongly promotes the outward expression and resolution of skin lesions.
Fang Feng

Fang Feng

Siler root

Dosage 1.5 - 3g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Urinary Bladder, Liver, Spleen

Role in Shi Wei Bai Du San

Dispels Wind-Dampness from the exterior and skin, resolves toxic accumulations at the body surface, and alleviates itching and swelling.
Deputies — Assists and enhances the King
Chai Hu

Chai Hu

Bupleurum root

Dosage 2 - 3g
Temperature Slightly Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Gallbladder, Lungs

Role in Shi Wei Bai Du San

Clears Heat from the Shao Yang level, spreads Liver Qi, and helps vent pathogenic factors from the half-exterior half-interior. Works with the King herbs to drive toxins outward.
Du Huo

Du Huo

Pubescent angelica root

Dosage 1.5 - 3g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Kidneys, Liver, Urinary Bladder

Role in Shi Wei Bai Du San

Dispels Wind-Dampness particularly from the lower body and deeper levels, complementing the superficial Wind-releasing action of Jing Jie and Fang Feng.
Assistants — Supports or moderates other herbs
Chuan Xiong

Chuan Xiong

Szechuan lovage rhizome

Dosage 2 - 3g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium

Role in Shi Wei Bai Du San

Invigorates Blood circulation, helps thrust out pus and toxins from skin lesions, and relieves pain. Its Blood-moving action supports the Wind-dispelling herbs.
Jie Geng

Jie Geng

Platycodon root

Dosage 2 - 3g
Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs

Role in Shi Wei Bai Du San

Opens the Lung Qi, resolves toxicity, and helps expel pus. Directs the formula's action upward and outward toward the skin surface.
Fu Ling

Fu Ling

Poria

Dosage 2 - 4g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Shi Wei Bai Du San

Drains Dampness through urination, strengthens the Spleen to resolve underlying Dampness that contributes to skin lesions. Provides a downward drainage route for toxins.
Ying Pi

Ying Pi

Cherry bark

Dosage 2 - 3g
Temperature Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Lungs

Role in Shi Wei Bai Du San

A distinctive ingredient of this formula, cherry bark clears Heat-toxin from the skin, relieves itching, and helps resolve suppurative skin conditions. Its inclusion reflects Hanaoka Seishū's use of locally available Japanese botanicals.
Sheng Jiang

Sheng Jiang

Fresh ginger rhizome

Dosage 1 - 3g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Stomach

Role in Shi Wei Bai Du San

Warms the middle, harmonizes the Stomach, and assists the exterior-releasing herbs in dispersing pathogenic factors from the surface.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 1 - 1.5g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Shi Wei Bai Du San

Harmonizes all the other herbs in the formula, clears residual toxicity, and protects the Spleen and Stomach from the dispersing nature of the Wind-releasing herbs.

Why This Combination Works

How the herbs in Shi Wei Bai Du San complement each other

Overall strategy

Shi Wei Bai Du San addresses skin conditions that arise when Wind, Dampness, and Heat-toxin accumulate in the exterior and skin layers. The formula's strategy is to release the exterior, dispel Wind-Dampness, promote Blood circulation to resolve stagnation, and provide drainage routes for toxins both upward through the skin and downward through urination.

King herbs

Jing Jie and Fang Feng jointly serve as the King herbs. Jing Jie is light, aromatic, and particularly effective at releasing the exterior and venting skin rashes. Fang Feng dispels Wind-Dampness from the body surface and is classically known for treating skin conditions with itching and swelling. Together they provide the primary therapeutic thrust: driving Wind and toxic pathogens outward from the skin.

Deputy herbs

Chai Hu clears Heat from the Shao Yang (half-exterior, half-interior) level and spreads Liver Qi, helping to vent deeper-seated Heat-toxin toward the surface where it can be expelled. Du Huo dispels Wind-Dampness from the lower body and deeper tissue layers, ensuring the formula reaches areas that Jing Jie and Fang Feng alone may not fully address. Together, the Deputies extend the King herbs' reach both vertically (upper and lower body) and horizontally (from surface to deeper layers).

Assistant herbs

Chuan Xiong invigorates Blood and helps thrust out pus from skin lesions, a reinforcing assistant that addresses the Blood stasis component of abscesses. Jie Geng opens the Lungs and directs the formula's action upward and outward, while also resolving toxicity and helping expel pus. Fu Ling provides a drainage route for Dampness through urination and strengthens the Spleen to address the root of Damp accumulation, serving as a restraining assistant that prevents the strongly dispersing herbs from scattering Qi without resolution. Ying Pi (cherry bark) is the formula's signature ingredient, clearing Heat-toxin from the skin and relieving itching. Sheng Jiang warms the Stomach and assists the dispersing action of the exterior-releasing herbs.

Envoy herbs

Gan Cao harmonizes all the herbs in the formula and provides mild toxin-clearing action of its own. It also protects the middle Qi from the strongly dispersing nature of the other herbs.

Notable synergies

Jing Jie paired with Fang Feng is one of the most classical combinations for treating Wind-related skin conditions, as their combined action of releasing the exterior and dispelling Wind is greater than either alone. Chuan Xiong paired with Jie Geng creates a pus-expelling effect: Chuan Xiong moves stagnant Blood while Jie Geng lifts and directs this action outward. The pairing of Fu Ling with the exterior-releasing herbs ensures Dampness is resolved both through the skin surface (sweating) and through the urinary tract (drainage), providing two exit routes for pathogenic Dampness.

How to Prepare

Traditional preparation instructions for Shi Wei Bai Du San

Traditionally prepared as a crude powder (散剂). The herbs are ground into a coarse powder and mixed. A standard single dose is approximately 6g of the powder, decocted in about 150ml of water until reduced to roughly 100ml, then strained and taken warm.

In modern clinical practice, this formula is more commonly prepared as a decoction (煎剤) or taken as concentrated granules or capsules. When prepared as a decoction, combine all herbs in approximately 400–600ml of water, bring to a boil, then simmer for 20–30 minutes. Strain and divide into two doses to be taken morning and evening, typically before meals.

Common Modifications

How practitioners adapt Shi Wei Bai Du San for specific situations

Added
Yi Yi Ren

15 - 30g, strengthens Spleen, drains Dampness, and clears pus from skin

Yi Yi Ren powerfully drains Dampness and has a specific action of clearing pus from skin lesions. This modification, attributed to the 20th-century Kampo practitioner Domei Yakazu, is one of the most common additions for exudative skin conditions.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Shi Wei Bai Du San should not be used or requires extra caution

Caution

Toxic sores or abscesses that have already fully suppurated and ulcerated. This formula is designed for the early stage of skin lesions with redness, swelling, and pain, not for already-ruptured lesions.

Caution

Skin conditions caused by Yin deficiency with internal Heat. The formula's warm, dispersing nature can further damage Yin fluids.

Caution

Wind-Heat patterns with pronounced high fever, severe thirst, and a red tongue with yellow coating. The formula is primarily warm and pungent, which could aggravate excess Heat.

Caution

Chronic, deficiency-type skin conditions without signs of exterior pathogenic involvement (Wind, Dampness, or Toxic Heat). The formula is designed to expel pathogens, not to tonify.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Safety during pregnancy has not been established. According to Japanese pharmaceutical guidelines, use during pregnancy should only be considered when the expected therapeutic benefit outweighs potential risks. Several herbs in the formula (Chuan Xiong, Jing Jie, Fang Feng) have dispersing and Blood-moving properties that warrant caution. Consult a qualified practitioner before use during pregnancy.

Breastfeeding

No specific safety data exists for use during breastfeeding. The formula contains Gan Cao (licorice), whose active compound glycyrrhizin could theoretically transfer into breast milk. The formula's ingredients are generally mild, but prolonged use has not been studied in nursing mothers. Caution is advised; consult a practitioner before use while breastfeeding.

Children

Shi Wei Bai Du San has a long history of pediatric use in Japan and was originally designed with mild, well-tolerated herbs. The Tsumura formulation (No. 6) is commonly prescribed for children with appropriate dose reductions based on age and weight. General guidelines: children under 4 years typically receive one-third of the adult dose; ages 4 to 7 receive one-half; ages 7 to 15 receive two-thirds. Always consult a practitioner for pediatric dosing. Monitor for digestive upset, as children's Spleen function may be sensitive to the dispersing herbs in the formula.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Shi Wei Bai Du San

Gan Cao (Licorice): This formula contains Gan Cao, which may cause pseudoaldosteronism (low potassium, high blood pressure, fluid retention) when taken alongside other licorice-containing preparations or glycyrrhizin-based drugs. Risk increases with concurrent use of potassium-depleting diuretics (thiazides, loop diuretics), digoxin (low potassium increases toxicity risk), or corticosteroids.

Anticoagulant and antiplatelet medications: Chuan Xiong (Ligusticum) has mild Blood-invigorating properties that could theoretically enhance anticoagulant effects when combined with warfarin, heparin, or antiplatelet drugs like aspirin or clopidogrel. Although the dose in this formula is small, monitoring is advised.

Immunosuppressants: Because the formula modulates immune function (particularly macrophage activity), caution is warranted when combining it with immunosuppressive medications, as the interaction has not been studied.

Usage Guidance

Practical advice for getting the most out of Shi Wei Bai Du San

Best time to take

Before meals (30 minutes before eating) or between meals on an empty stomach, 2 to 3 times daily.

Typical duration

Acute skin conditions (boils, early-stage abscess): 5–14 days. Chronic or recurring conditions (acne, eczema, urticaria): 4–8 weeks, reassessed by a practitioner.

Dietary advice

While taking this formula, avoid greasy, fried, and heavily spiced foods, as these can generate internal Dampness and Heat that work against the formula's action. Limit alcohol, shellfish, and fermented or overly rich foods, which are considered potential triggers for skin flare-ups in TCM tradition. Favor light, easily digestible meals with plenty of fresh vegetables. Reducing sugar and dairy intake may also support the formula's skin-clearing effects. Drink adequate water to support the body in flushing out toxins.

Shi Wei Bai Du San originates from Experiential formula (經驗方) by Hanaoka Seishū (華岡青洲), Edo period Japan Edo period, Japan, c. 1760–1835 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Shi Wei Bai Du San and its clinical use

Asada Sōhaku (浅田宗伯, 1814–1894) noted in the Butsugō Yakushitsu Hōkan Kuketsu (勿誤薬室方函口訣) that Shi Wei Bai Du San (十味敗毒湯) is a modification of Jing Fang Bai Du San (荊防敗毒散), the formula from the Ming Dynasty text Wan Bing Hui Chun (万病回春, 1587). This positions it as a streamlined derivative focused specifically on skin and superficial suppurative conditions.

The Tsumura Kampo formulary description states its primary indications: acute and purulent skin disorders, urticaria, acute eczema, and athlete's foot, in patients of moderate constitution with skin redness, swelling, and pain in early-stage presentations.

Historical Context

How Shi Wei Bai Du San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Shi Wei Bai Du San (十味敗毒散/湯, "Ten-Ingredient Powder to Overcome Toxicity") was created by the renowned Japanese Edo-period surgeon Hanaoka Seishū (華岡青洲, 1760–1835). Hanaoka is best remembered as the first physician in recorded history to perform surgery under general anesthesia, achieving a successful breast cancer mastectomy in 1804, nearly 40 years before ether anesthesia was demonstrated in the West. He also created other still-used formulas including Shiunko (紫雲膏) and Chūōkō (中黄膏).

Hanaoka based Shi Wei Bai Du San on Jing Fang Bai Du San (荆防败毒散), a 15-ingredient formula found in Gong Tingxian's 1587 Ming Dynasty text Wan Bing Hui Chun (万病回春). Drawing on his extensive clinical experience treating skin and surgical conditions, Hanaoka streamlined the formula to just 10 ingredients, adding the distinctive Ying Pi (cherry bark, 櫻皮) and replacing several herbs. A key innovation was the substitution of Qiang Huo (notopterygium) with the more broadly acting Du Huo (pubescent angelica), and the inclusion of Sheng Jiang (fresh ginger) to harmonize the Stomach. Some versions use Boku Soku (樸樕, oak bark) instead of cherry bark.

The formula became one of the most widely prescribed Kampo medicines in Japan for dermatological conditions. It is approved by the Japanese Ministry of Health as a pharmaceutical-grade prescription Kampo medicine (Tsumura formula No. 6) and remains a first-line herbal treatment for inflammatory acne, eczema, urticaria, and suppurative skin conditions in Japanese clinical practice today.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Shi Wei Bai Du San

1

Suppression of P. acnes-induced Dermatitis by Jumihaidokuto, Modifying Macrophage Functions (Preclinical, 2015)

Sekiguchi K, Koseki J, Tsuchiya K, et al. Evidence-Based Complementary and Alternative Medicine, 2015, 2015:439258.

This animal study found that oral administration of Jumihaidokuto suppressed skin inflammation induced by Propionibacterium acnes bacteria in rats. The formula worked by enhancing macrophage accumulation and function at the inflammation site, through a mechanism distinct from prednisolone. Active constituents liquiritigenin and isoliquiritin promoted phagocytic activity.

2

Jumihaidokuto Decreases the Disease Activity of Palmoplantar Pustulosis (Clinical study, 2016)

Mizawa M, Makino T, Inami C, Shimizu T. Dermatology Research and Practice, 2016, 2016:4060673.

Patients with palmoplantar pustulosis were given Jumihaidokuto (6.0 g/day) for 4 to 8 weeks in addition to their existing medications. The palmoplantar pustular psoriasis area and severity index (PPPASI) decreased significantly after treatment, suggesting clinical effectiveness for this condition.

3

Impact of Jumihaidokuto on Treatment of Chronic Spontaneous Urticaria: A Randomized Controlled Study (RCT, 2019)

Murota H, Azukizawa H, Katayama I. Chinese Journal of Integrative Medicine, 2019, 25(11):820-824.

This randomized controlled trial investigated the effects of Jumihaidokuto on chronic spontaneous urticaria. The study provided evidence that the formula may be beneficial as an adjunctive treatment for chronic hives.

4

Oral Administration of Jumihaidokuto Inhibits UVB-induced Skin Damage and PGE2 Production in Hairless Mice (Preclinical, 2021)

Journal of Natural Medicines, 2021, 75(2):344-356.

This study showed that 3 weeks of oral pretreatment with Jumihaidokuto protected against UVB-induced skin damage in mice, improving skin hydration and reducing epidermal thickening. The protective effect was associated with suppression of prostaglandin E2 production, suggesting anti-inflammatory and skin-barrier-protective properties.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.