Herb Flower (花 huā)

Ye Ju Hua

Wild chrysanthemum flower · 野菊花

Chrysanthemum indicum L. · Chrysanthemi Indici Flos

Images shown are for educational purposes only

Wild chrysanthemum flower is a potent heat-clearing herb used primarily for treating infections, boils, sore throats, and red swollen eyes. It is considerably stronger than regular chrysanthemum (Ju Hua) in its detoxifying action and is a key ingredient in formulas for skin abscesses and inflammatory conditions. Because of its cold nature, it should be used with care by those with weak digestion.

TCM Properties

Temperature

Slightly Cool

Taste

Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)

Channels entered

Liver, Heart

Parts used

Flower (花 huā)

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What This Herb Does

Every herb has a specific set of actions — here's what Ye Ju Hua does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Ye Ju Hua is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Ye Ju Hua performs to restore balance in the body:

How these actions work

'Clears Heat and resolves toxins' is the primary action of Wild Chrysanthemum. This means it combats what TCM calls 'toxic Heat', the kind of intense, localized inflammation seen in boils (furuncles), abscesses, carbuncles, and infected sores that are red, hot, swollen, and painful. Its bitter and acrid flavour combined with its cool nature gives it strong detoxifying power. Classical sources describe it as excelling among the chrysanthemum family for this purpose, and it is considered a go-to herb for conditions the classical texts call 'ding chuang' (疔疮, deep-rooted sores resembling nail heads).

'Drains Fire and reduces swelling' means it actively draws out excess Heat that has accumulated and caused tissue swelling. This applies to swollen, painful throats (pharyngitis, tonsillitis), swollen lymph nodes, and inflamed eyes. It can be used both internally as a decoction and externally as a wash or poultice for localized swelling.

'Calms the Liver and clears Liver Fire' refers to its ability to cool down an overactive Liver system. In TCM, when Liver Fire flares upward it causes headaches, dizziness, red irritated eyes, and high blood pressure. Wild Chrysanthemum enters the Liver channel and has a descending, cooling quality that helps settle this upward-surging Heat. It is commonly paired with herbs like Xia Ku Cao (Prunella) and Jue Ming Zi (Cassia seed) for Liver-Heat type hypertension.

'Disperses Wind-Heat' means it can help release the early stages of a Wind-Heat invasion, the TCM equivalent of the common cold or flu with sore throat, fever, and headache. However, this is a secondary action. Regular chrysanthemum (Ju Hua) is preferred for Wind-Heat colds; Wild Chrysanthemum is chosen when the presentation involves more pronounced toxic Heat, such as severe throat inflammation or developing skin infections.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony. Ye Ju Hua is used to help correct these specific patterns.

Why Ye Ju Hua addresses this pattern

Toxic Heat is a pattern of intense, concentrated Heat that produces red, swollen, hot, painful lesions, often with pus formation. Wild Chrysanthemum's bitter and acrid flavour, combined with its cool temperature, makes it one of the strongest Heat-clearing and toxin-resolving herbs in the chrysanthemum family. Its bitter taste drains Heat downward and its acrid quality disperses and breaks up the toxic accumulation, while its affinity for the Liver and Heart channels allows it to cool the Blood and clear Heat from these organ systems. This directly addresses the pathomechanism of toxic Heat congesting in the flesh and skin.

A practitioner would look for one or more of these signs

Boils

Red, swollen, hot, painful boils or carbuncles

Skin Abscess

Deep-rooted sores with pus formation

Sore Throat

Swollen, painful throat with redness

Fever

Fever accompanying acute infection

Commonly Used For

These are conditions where Ye Ju Hua is frequently used — but only when they arise from the specific patterns it addresses, not in all cases

Arises from: Toxic-Heat

TCM Interpretation

TCM understands boils and carbuncles as the result of toxic Heat accumulating in the skin and underlying flesh. This Heat may arise from external invasion by pathogenic factors, internal buildup from dietary excess (rich, greasy, or spicy foods), or emotional stress generating internal Fire. The Heat 'stews' in the local tissue, corrupts the flesh, and produces the classic signs of redness, swelling, heat, and pain. If the Heat is not cleared, it thickens into pus. The Liver channel, which governs the smooth flow of Qi, is often involved because stagnation easily transforms into Heat.

Why Ye Ju Hua Helps

Wild Chrysanthemum is one of TCM's most relied-upon herbs for toxic Heat in the skin. Its bitter, acrid, and cool properties directly drain and disperse the concentrated Heat causing the boil. It enters the Liver channel, addressing the stagnant Heat that commonly underlies these lesions. It can be taken internally as a decoction and simultaneously applied externally as a fresh poultice, attacking the problem from both inside and outside. Classical formulas pair it with herbs like Jin Yin Hua (Honeysuckle), Pu Gong Ying (Dandelion), and Zi Hua Di Ding (Viola) to amplify the detoxifying effect.

Also commonly used for

Skin Abscess

Acute suppurative skin infections

Sore Throat

Acute pharyngitis and tonsillitis

Eczema

Inflammatory skin rashes with redness and itching

Lumps

Acute parotitis (mumps) with swelling

Mastitis

Acute breast inflammation, especially early stage

Upper Respiratory Tract Infections

Wind-Heat type common cold or flu

Acne

Inflammatory acne with red, painful pustules

Cervicitis

Chronic cervical inflammation, used topically and internally

Herb Properties

Every herb has an inherent temperature, taste, and affinity for specific channels — these properties determine how it interacts with the body

Temperature

Slightly Cool

Taste

Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)

Channels Entered

Liver Heart

Parts Used

Flower (花 huā)

Dosage & Preparation

These are general dosage guidelines for Ye Ju Hua — always follow your practitioner's recommendation, as dosages vary based on the formula and your individual condition

Standard dosage

9-15g

Maximum dosage

Up to 30-60g when using fresh herb (鲜品) for acute Heat-toxin conditions, under practitioner supervision. Dried herb should generally not exceed 15g in standard decoction.

Dosage notes

Use the lower end of the range (9-10g) for mild conditions such as early-stage sore throat or red eyes. Use the higher end (12-15g) for acute inflammatory conditions like boils, abscesses, or severe pharyngitis. For external use (as a wash or compress for skin conditions, boils, or eczema), there is no strict gram limit. The fresh herb can be used in larger amounts (30-60g) when available. When making Ye Ju Hua tea for occasional use (not long-term), 1-2g is sufficient and reflects its stronger potency compared to regular chrysanthemum tea. Excessive dosage or prolonged use can cause stomach discomfort, poor appetite, and loose stools due to its bitter and cold nature.

Preparation

No special decoction handling required. Ye Ju Hua is added to the decoction with other herbs and decocted normally. For external use, it can be decocted in water for washing or compressing affected areas, or the fresh herb can be pounded and applied directly as a poultice.

Common Herb Pairs

These ingredients are traditionally combined with Ye Ju Hua for enhanced therapeutic effect

Jin Yin Hua
Jin Yin Hua Jin Yin Hua 15-20g : Ye Ju Hua 10-15g

Together, Wild Chrysanthemum and Honeysuckle create a powerful detoxifying combination. Jin Yin Hua clears Heat and toxins broadly through the Lung and Stomach channels, while Ye Ju Hua focuses its detoxifying action through the Liver and Heart channels. The pair covers a wider range of toxic Heat conditions than either herb alone, enhancing both the breadth and intensity of the detoxifying effect.

When to use: For any presentation of toxic Heat with red, swollen, painful sores, abscesses, or severe sore throat. This is the core pairing within Wu Wei Xiao Du Yin (Five-Ingredient Toxin-Clearing Drink).

Pu Gong Ying
Pu Gong Ying 1:1 (typically 15g each)

Dandelion and Wild Chrysanthemum both clear Heat and resolve toxins, but Pu Gong Ying has a particular affinity for the breast and Liver channel and also promotes urination to drain Heat downward. Together they provide a stronger and more comprehensive detoxifying effect, particularly for breast and skin abscesses.

When to use: Acute mastitis (breast abscess) in the early inflammatory stage, or any skin abscess with pronounced redness and swelling. Often used together in Wu Wei Xiao Du Yin.

Lian Qiao
Lian Qiao 1:1 (typically 10-15g each)

Forsythia fruit and Wild Chrysanthemum both clear Heat and resolve toxins while also dispersing exterior Wind-Heat. Lian Qiao excels at dispersing stagnant Heat in the upper body and is especially effective at the boundary between exterior and interior conditions. Combined, they treat infections that involve both surface symptoms and deeper toxic Heat.

When to use: Upper respiratory infections with concurrent skin sores or lymph node swelling, or early-stage abscesses where toxic Heat has not yet fully localized.

Xia Ku Cao
Xia Ku Cao 1:1 (typically 15g each)

Prunella and Wild Chrysanthemum both clear Liver Fire and calm the Liver. Xia Ku Cao is particularly effective at softening hardness and dissolving nodules (like swollen lymph nodes or thyroid nodules), while Ye Ju Hua more strongly clears toxic Heat. Together they address Liver Fire presentations that involve both inflammation and masses or swelling.

When to use: Liver-Heat type hypertension with headache and red eyes, swollen lymph nodes (scrofula), or inflammatory eye conditions from Liver Fire.

Key Formulas

These well-known formulas feature Ye Ju Hua in a prominent role

Wu Wei Xiao Du Yin 五味消毒饮 Deputy

Wu Wei Xiao Du Yin (Five-Ingredient Toxin-Clearing Drink) from the Yi Zong Jin Jian is the most iconic formula containing Wild Chrysanthemum. It consists of five Heat-clearing, toxin-resolving herbs (Jin Yin Hua, Ye Ju Hua, Pu Gong Ying, Zi Hua Di Ding, and Zi Bei Tian Kui Zi) and is the go-to formula for boils, carbuncles, and deep-rooted sores with red, hot, swollen, painful skin. Ye Ju Hua serves as Deputy, reinforcing the King herb Jin Yin Hua and specifically contributing its Liver-clearing and toxin-resolving action. Modern research confirmed that among the five herbs, Wild Chrysanthemum showed the strongest antibacterial effect.

Comparable Ingredients

These ingredients have overlapping uses — here's how to tell them apart

Ju Hua
Ye Ju Hua vs Ju Hua

Both are chrysanthemum flowers that clear Heat from the Liver and benefit the eyes, but they differ substantially. Regular chrysanthemum (Ju Hua) is sweet and bitter, enters the Lung and Liver, and is primarily used for Wind-Heat colds, blurred vision, and calming Liver Yang. Wild chrysanthemum (Ye Ju Hua) is bitter and acrid, enters the Liver and Heart, and has a much stronger Heat-clearing and toxin-resolving action. Choose Ju Hua for gentle exterior-releasing and vision support; choose Ye Ju Hua when toxic Heat is the main problem, as in boils, abscesses, and severe infections. Ye Ju Hua's stronger bitter-cold nature also means it is more likely to damage the Spleen and Stomach if overused.

Pu Gong Ying
Ye Ju Hua vs Pu Gong Ying

Both clear Heat and resolve toxins for sores and abscesses. Pu Gong Ying (Dandelion) enters the Liver and Stomach, has a particular affinity for breast abscesses and is also effective at promoting urination to drain Damp-Heat. Ye Ju Hua enters the Liver and Heart, has a stronger action at calming Liver Fire and treating head and facial infections, and is better for conditions with prominent redness, swelling, and toxicity of the skin. For breast abscess, Pu Gong Ying is the primary choice; for deep-rooted boils and facial sores, Ye Ju Hua takes precedence.

Zi Hua Di Ding
Ye Ju Hua vs Zi Hua Di Ding

Both are key herbs in Wu Wei Xiao Du Yin and both strongly clear Heat and resolve toxins. Zi Hua Di Ding (Viola) enters the Heart and Liver, excels at clearing Blood-level Heat, and is often chosen for hot, red, swollen sores. Ye Ju Hua has additional Liver-calming and Wind-dispersing actions, making it more versatile for conditions that also involve headache, dizziness, red eyes, or hypertension from Liver Fire. For pure toxic sores, either can be used; when Liver symptoms are also present, Ye Ju Hua is preferred.

Identity & Adulterants

Related species and common adulterations to be aware of when sourcing Ye Ju Hua

Ye Ju Hua (wild chrysanthemum, Chrysanthemum indicum) is sometimes confused with cultivated chrysanthemum (Ju Hua, Chrysanthemum morifolium). The two are distinct medicines with different clinical applications: Ju Hua is milder and favours dispersing Wind-Heat and brightening the eyes, while Ye Ju Hua is much more bitter and strongly clears Heat-toxin. Authentic Ye Ju Hua flower heads are smaller (1.5-2.5 cm), nearly spherical, and deep yellow, with a pronounced bitter taste. Ju Hua flower heads are larger and less bitter. Another potential adulterant is Yan Xiang Ju Hua (岩香菊花), the flower head of Chrysanthemum lavandulaefolium, which has smaller heads (1-1.5 cm) with linear outer involucral bracts rather than the ovate bracts of true Ye Ju Hua. The two can be distinguished by examining the bract shape and flower head size.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herb.

Toxicity Classification

Classical Chinese pharmacopoeia toxicity rating for Ye Ju Hua

Slightly toxic

The Ben Cao Hui Yan classifies Ye Ju Hua as having "slight toxicity" (小毒), though the Sichuan Materia Medica records it as non-toxic. The Chinese Pharmacopoeia classifies it as slightly toxic. In practice, the "slight toxicity" mainly manifests as gastrointestinal irritation when taken in excessive doses or over prolonged periods, due to its strongly bitter and cold properties. Symptoms of overconsumption may include nausea, stomach discomfort, reduced appetite, and loose stools. Preclinical animal studies have shown no mortality or clinical signs of toxicity at oral doses up to 2,000 mg/kg body weight in mice, suggesting a wide safety margin at normal therapeutic doses. At standard decoction dosages (9-15g), Ye Ju Hua is considered safe for short-term use. The risk comes from chronic overuse, which may injure Spleen and Stomach Yang.

Contraindications

Situations where Ye Ju Hua should not be used or requires extra caution

Caution

Spleen and Stomach deficiency-cold (脾胃虚寒): People with cold constitutions who experience symptoms like cold limbs, loose stools, poor appetite, or abdominal pain after eating cold foods should avoid Ye Ju Hua. Its bitter, cold nature can further damage the already weakened digestive system and its warming functions.

Caution

Pregnancy: Ye Ju Hua's cold nature and its traditional classification as slightly toxic warrant caution during pregnancy. Pregnant women should avoid this herb unless specifically prescribed by a qualified practitioner.

Caution

Qi deficiency without Heat signs: Ye Ju Hua is a cooling, draining herb. Using it in people who are already depleted in Qi, without any signs of Heat or toxicity, can further weaken their constitution and deplete the body's resources.

Caution

Long-term, high-dose use: Because Ye Ju Hua is more bitter and cold than cultivated chrysanthemum (Ju Hua), prolonged or excessive use can injure Spleen and Stomach Yang, causing digestive discomfort, poor appetite, or diarrhea.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Ye Ju Hua is classified as "use with caution" during pregnancy (孕妇慎用) in the Chinese Pharmacopoeia. Its strongly bitter, cold nature may be harmful to the fetus by depleting the mother's Spleen and Stomach Yang, which is essential for nourishing the pregnancy. Additionally, the Ben Cao Hui Yan's traditional classification of "slight toxicity" adds a further note of caution. There are no specific studies on teratogenicity, but given the availability of safer alternatives for clearing Heat during pregnancy, Ye Ju Hua should generally be avoided unless prescribed by a knowledgeable practitioner for a clear indication where the benefits outweigh the risks.

Breastfeeding

There are no specific studies on the transfer of Ye Ju Hua constituents into breast milk. Given its bitter, cold nature, the main concern is that it could potentially reduce the mother's appetite and digestive function, indirectly affecting milk production. The classical designation of slight toxicity also warrants prudence. If a breastfeeding mother has a clear Heat-toxin condition requiring this herb, short-term use at standard doses under practitioner guidance is generally considered acceptable, but routine or prolonged use should be avoided.

Children

Ye Ju Hua may be used cautiously in children for short-term treatment of Heat-toxin conditions (such as boils or sore throat), but the dosage should be reduced according to age and body weight, typically one-third to one-half of the adult dose. Children's digestive systems are immature and more susceptible to damage from bitter, cold herbs. It should not be used as a routine tea or health drink for children. The classical teaching that children are of "pure Yang" constitutions does not mean they tolerate cold herbs well. In fact, their Spleen and Stomach functions are still developing, making prolonged use of cold herbs particularly harmful.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Ye Ju Hua

Anticoagulant and antiplatelet medications (e.g. warfarin, aspirin): Ye Ju Hua contains flavonoid compounds (including quercetin and luteolin) that have demonstrated blood-pressure-lowering and mild blood-thinning properties in preclinical studies. Though direct clinical interaction studies with Ye Ju Hua are lacking, chrysanthemum-derived flavonoids have the theoretical potential to enhance the effects of anticoagulants, potentially increasing bleeding risk. Concurrent use should be monitored.

Antihypertensive medications: Ye Ju Hua has demonstrated hypotensive effects in animal studies, primarily by reducing peripheral vascular resistance. If combined with antihypertensive drugs, there is a theoretical risk of additive blood-pressure-lowering effects, which could cause hypotension in susceptible individuals.

Iron supplements and mineral-based medications: Like other flavonoid-rich herbs, the tannins and organic acids in Ye Ju Hua may bind to iron and certain metal ions, potentially reducing absorption if taken simultaneously. It is advisable to space their administration by at least 1-2 hours.

Dietary Advice

Foods and dietary considerations when taking Ye Ju Hua

While taking Ye Ju Hua, avoid excessive consumption of cold, raw foods (such as ice cream, raw salads, chilled drinks) as these compound the herb's cold nature and may further burden the Spleen and Stomach. Warm, easily digestible foods are preferable during treatment. Since Ye Ju Hua is used to clear Heat and toxin, it is also advisable to avoid spicy, greasy, and fried foods that may generate more internal Heat and counteract the therapeutic effect. Light, bland foods support the herb's detoxifying action.

Botanical Description

Physical characteristics and morphology of the Ye Ju Hua source plant

Chrysanthemum indicum L. is a perennial herbaceous plant in the Asteraceae (daisy) family, growing 25 to 100 cm tall from creeping underground rhizomes. The stems are erect or spreading, branched, and sparsely covered with fine hairs. The middle stem leaves are ovate to elliptic-ovate, 3 to 7 cm long, pale green on both surfaces with sparse pubescence, and pinnately lobed or divided. The lower leaves typically wither by flowering time.

The flower heads are arranged in loose, flat-topped clusters (corymbs). Each small flower head is 1.5 to 2.5 cm across, much smaller than cultivated chrysanthemum, with a single ring of bright yellow ray florets surrounding a dense centre of deeper yellow disc florets. The involucral bracts are arranged in 4 to 5 rows with broad, papery white or brown margins. Flowering occurs from June through November, with peak bloom in autumn (September to October).

The plant grows wild on mountain slopes, grasslands, riverbanks, field edges, roadsides, and even coastal saline soils at elevations from 100 to 2,900 metres. It thrives in cool, moist climates and tolerates cold well. When bruised, the foliage releases a pungent, refreshing fragrance that is somewhat lemony and reminiscent of chamomile.

Sourcing & Harvesting

Where Ye Ju Hua is sourced, when it's harvested or collected, and how to assess quality

Harvesting season

Autumn and early winter, when the flower buds have just begun to open (typically September to November). The flowers are sun-dried, or briefly steamed then dried.

Primary growing regions

Ye Ju Hua is widely distributed across China, found in virtually all provinces from the northeast through the south and southwest. Its original native range centres on Shanxi and Shaanxi provinces, with broad distribution throughout Hebei, Henan, Hubei, Jiangsu, Zhejiang, Anhui, Jiangxi, Sichuan, Guizhou, and Guangdong. Unlike cultivated chrysanthemum (Ju Hua), which has famous terroir regions such as the "Four Great Huai Medicines" of Henan, wild chrysanthemum does not have a single dominant terroir region because it grows abundantly in the wild. Historical sources from the Qing Dynasty onward have praised the wild chrysanthemum produced in Suichang, Zhejiang as being of particularly fine quality. Outside China, the plant also grows in Japan, Korea, India, and parts of Southeast Asia.

Quality indicators

Good quality Ye Ju Hua flower heads should be nearly spherical and intact, not yet fully opened (buds just beginning to bloom are preferred). The colour should be a vivid yellow to brownish-yellow. The aroma should be distinctly fragrant and the taste decidedly bitter. When examined closely, the outer involucral bracts should appear greyish-green to pale brown with fine white hairs and papery margins. Stems and stalks should be minimal. Avoid material that is dark brown or blackened, overly crumbled, mouldy, or lacking in fragrance. The presence of a strong, characteristic bitter taste confirms authenticity and potency.

Classical Texts

Key passages from the classical Chinese medical texts that describe Ye Ju Hua and its therapeutic uses

《本草汇言》(Compendium of Materia Medica Discussions)

Original: 破血疏肝,解疔散毒。主妇人腹内宿血,解天行火毒丹疔。洗疮疥,又能去风杀虫。

Translation: "Breaks Blood stasis and courses the Liver, resolves boils and disperses toxin. Treats women's abdominal static Blood, resolves epidemic Fire-toxin and boils. Used as a wash for sores and scabies, it also dispels Wind and kills parasites."

《本草纲目》(Comperta Medica Materia, Li Shizhen)

Original: 利五脉、调四肢,治头风热、脑骨肿痛、养目血、去翳膜、主肝气不足。

Translation: "Benefits the five vessels, regulates the four limbs, treats Wind-Heat of the head, swelling and pain of the cranial bones, nourishes the Blood of the eyes, removes eye films and opacities, and addresses insufficiency of Liver Qi."

《牧竖闲谈》(Casual Talks of Herdsmen, Song Dynasty, Jing Huan)

Original: 真菊延龄,野菊泄人。

Translation: "True chrysanthemum prolongs life; wild chrysanthemum drains the person." This classical aphorism highlights the distinction between cultivated chrysanthemum (which gently tonifies) and wild chrysanthemum (which powerfully drains Heat and toxin, and should not be used carelessly as a tonic).

《本草备要》(Essentials of the Materia Medica)

Original: 性甘苦微寒,有疏风热,清头目之功。

Translation: "Its nature is sweet, bitter, and slightly cold. It has the ability to disperse Wind-Heat and clear the head and eyes."

Historical Context

The history and evolution of Ye Ju Hua's use in Chinese medicine over the centuries

Wild chrysanthemum first appeared in Chinese medical literature under the name "Ku Yi" (苦薏, meaning "bitter seed") in the Ben Cao Jing Ji Zhu (本草经集注) by Tao Hongjing during the Southern and Northern Dynasties period (around the 5th century CE). Over subsequent centuries, it went by many folk names including "Ye Shan Ju" (wild mountain chrysanthemum), "Lu Bian Ju" (roadside chrysanthemum), and "Huang Ju Zi" (little yellow chrysanthemum).

It was Li Shizhen in the Ming Dynasty who elevated Ye Ju Hua to the status of an independent medicinal entry in the Ben Cao Gang Mu (本草纲目), clearly distinguishing it from cultivated chrysanthemum (Ju Hua) and documenting that the entire plant, from root to flower, possesses medicinal value. Before Li Shizhen, wild chrysanthemum was often discussed only as a lesser variety of chrysanthemum rather than a distinct medicine in its own right. The famous Song Dynasty saying "true chrysanthemum prolongs life; wild chrysanthemum drains the person" (真菊延龄,野菊泄人) captures an important clinical principle: while cultivated chrysanthemum is mild enough for long-term use as a health tonic, wild chrysanthemum is far more bitter and draining and should be used therapeutically rather than as an everyday tea.

In modern clinical practice, Ye Ju Hua's reputation as a powerful Heat-clearing and toxin-resolving herb has led to its widespread use well beyond traditional boils and abscesses. It is a key ingredient in the classical formula Wu Wei Xiao Du Yin (Five-Ingredient Decoction to Eliminate Toxin) and appears in numerous prepared medicines listed in the Chinese Pharmacopoeia. Its name "Ye Ju Hua" literally means "wild chrysanthemum flower," distinguishing it clearly from the cultivated varieties used in gentler applications like flower tea.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Ye Ju Hua

1

Comprehensive Review of Botany, Phytochemistry and Pharmacology (Review, 2020)

Shao Y, Sun Y, Li D, Chen Y. Chrysanthemum indicum L.: A Comprehensive Review of its Botany, Phytochemistry and Pharmacology. American Journal of Chinese Medicine, 2020, 48(4):871-897

This comprehensive review surveyed over 190 chemical compounds isolated from Chrysanthemum indicum, including flavonoids, terpenoids, phenylpropanoids, and phenolic acids. The authors found that extracts and isolated compounds demonstrated anti-inflammatory, antioxidant, antimicrobial, anticancer, immune-regulatory, and liver-protective activities in laboratory and animal studies. The review noted that clinical research and quality control methods remain insufficient and warrant further development.

PubMed
2

Antimicrobial, Anti-inflammatory, Antioxidant, and Immunomodulatory Properties (Narrative Review, 2025)

Frontiers in Pharmacology, 2025, 16:1538311

This review compared the pharmacological properties of Chrysanthemum morifolium and Chrysanthemum indicum by searching PubMed literature from 2000 to 2024, identifying 785 relevant articles. The authors found that while both species contain bioactive flavonoids, terpenoids, and phenylpropanoids, their distinct phytochemical profiles may lead to differentiated therapeutic advantages in anti-infective applications. The review highlighted the synergistic potential of these herbs with conventional therapies.

Link
3

Biological Activities: Molecular Prospective (Review, 2024)

Mohamad NV, Zahari CNMC. Biological activities of Chrysanthemum morifolium and Chrysanthemum indicum: molecular prospective. Journal of Applied Pharmaceutical Sciences Online, 2024

This review examined the molecular mechanisms underlying the biological effects of Chrysanthemum indicum. Preclinical studies showed it can reduce pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), inhibit NF-kB signalling, promote apoptosis in cancer cells via caspase activation, and provide antioxidant protection. Importantly, toxicology assessments found no mortality or adverse effects at 2,000 mg/kg body weight orally in mice over 15 days, suggesting a favourable safety profile.

Link

Research on individual TCM herbs is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.