Shen Ling Bai Zhu San

Ginseng, Poria, and White Atractylodes Powder · 参苓白术散

Also known as: Shen Ling Bai Zhu Wan (参苓白术丸, Ginseng, Poria, and White Atractylodes Pill), Bai Zhu Tiao Yuan San (白术调元散), Shen Zhu Yin (参术饮)

A gentle classical formula that strengthens weak digestion, clears excess internal dampness, and stops diarrhea. It is commonly used for people experiencing chronic loose stools, bloating, poor appetite, fatigue, and a sallow complexion caused by a weakened digestive system. By supporting the Spleen and Stomach, it also indirectly benefits the Lungs, helping with shortness of breath and chronic cough with thin white phlegm.

Origin Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方) — Sòng dynasty, 1107 CE
Composition 10 herbs
Ren Shen
King
Ren Shen
Bai Zhu
King
Bai Zhu
Fu Ling
King
Fu Ling
Shan Yao
Deputy
Shan Yao
Lian Zi
Deputy
Lian Zi
Bai Bian Dou
Deputy
Bai Bian Dou
Yi Yi Ren
Deputy
Yi Yi Ren
Sha Ren
Assistant
Sha Ren
+2
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Shen Ling Bai Zhu San is designed to correct these specific patterns.

Why Shen Ling Bai Zhu San addresses this pattern

This is the primary pattern this formula was designed to treat. When the Spleen's Qi is weak, it cannot properly transform food and fluids, leading to incomplete digestion and accumulation of Dampness in the Middle Burner. The underpinning logic is that Dampness is both a product of Spleen deficiency and a further burden on it, creating a vicious cycle. Ren Shen, Bai Zhu, and Fu Ling directly restore the Spleen's transforming and transporting capacity, while Shan Yao, Lian Zi, Bai Bian Dou, and Yi Yi Ren reinforce this action and drain the accumulated Dampness. Sha Ren keeps Qi moving so the dampness does not stagnate further. The formula breaks the cycle by addressing both the root weakness and the pathological product simultaneously.

A practitioner would look for one or more of these signs

Chronic Diarrhea

Loose stools or watery diarrhea, often chronic

Loss Of Appetite

Reduced appetite with poor digestion of food

Abdominal Distention

Bloating and a sense of fullness in the stomach and chest

Eye Fatigue

Tiredness and weakness of the limbs

Weight Loss

Emaciation or thin frame with sallow, yellowish complexion

Borborygmi

Gurgling sounds in the intestines (borborygmus)

Nausea Or Vomiting

Occasional nausea or vomiting

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Shen Ling Bai Zhu San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, diarrhea-predominant IBS is most often understood as a condition rooted in Spleen Qi deficiency. The Spleen is responsible for 'transforming and transporting' food and fluids. When the Spleen is weak, it cannot properly separate the 'clear' (usable nutrients) from the 'turbid' (waste), and Dampness accumulates in the intestines. This leads to the hallmark symptoms of loose stools, bloating, and abdominal discomfort. Emotional stress can further impair the Spleen's function, as the Liver (which governs the smooth flow of Qi) may 'overact' on the already weakened Spleen, worsening symptoms during periods of anxiety or tension.

Why Shen Ling Bai Zhu San Helps

Shen Ling Bai Zhu San directly addresses the Spleen Qi deficiency and Dampness accumulation that drive diarrhea-predominant IBS. The King herbs (Ren Shen, Bai Zhu, Fu Ling) restore digestive strength, while the Deputy herbs (Yi Yi Ren, Bai Bian Dou, Lian Zi, Shan Yao) drain Dampness and firm the stools. Sha Ren's aromatic quality reduces bloating by keeping Qi moving through the digestive tract. Modern pharmacological research has shown that the formula can regulate intestinal motility, with small doses stimulating movement in sluggish bowels and larger doses relieving intestinal spasms, while also improving the gut's ability to absorb water, directly reducing watery diarrhea.

Also commonly used for

Ulcerative Colitis

Maintenance phase with Spleen deficiency pattern

Chronic Bronchitis

With copious thin white phlegm and weak digestion

Dyspepsia

With bloating, poor appetite and loose stools

Malnutrition

In children with poor digestion and failure to thrive

Chronic Fatigue Syndrome

When rooted in digestive weakness

Diabetes

Spleen deficiency with Dampness presentation

Chronic Nephritis

With proteinuria and Spleen Qi deficiency

Leukorrhea

Chronic vaginal discharge from Spleen deficiency with Dampness

Anemia

When associated with poor absorption and Spleen weakness

What This Formula Does

Every TCM formula has a specific set of actions — here's what Shen Ling Bai Zhu San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Shen Ling Bai Zhu San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Shen Ling Bai Zhu San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Shen Ling Bai Zhu San works at the root level.

The Spleen is the body's central digestive engine, responsible for transforming food and drink into usable nourishment and for managing the body's fluids. When Spleen Qi becomes weak, whether from chronic illness, poor diet, overwork, or constitutional vulnerability, two problems arise simultaneously. First, the body cannot properly extract nourishment from food, leading to poor appetite, fatigue, weight loss, and a sallow complexion. Second, the weakened Spleen loses its ability to transform and transport fluids, causing Dampness to accumulate internally. This excess Dampness settles in the digestive tract and produces bloating, a heavy feeling in the limbs, loose stools or diarrhea, and a white greasy tongue coating.

Because the Spleen and Lungs are closely linked (the Spleen is the "mother" of the Lungs in five-phase theory), prolonged Spleen weakness also starves the Lungs of Qi. When Lung Qi becomes insufficient, the Lungs can no longer properly regulate the water passages or maintain strong breathing, which may result in shortness of breath, a weak cough, and thin watery phlegm. The classical text describes this condition as "Spleen and Stomach weakness with inability to eat, drowsiness and lack of strength, fullness in the middle, palpitations and shortness of breath, vomiting and diarrhea." Shen Ling Bai Zhu San addresses both the root (Spleen Qi deficiency) and the branch (internal Dampness accumulation), while also replenishing Lung Qi through the principle known as "cultivating Earth to generate Metal" (培土生金).

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Neutral

Taste Profile

Predominantly sweet and bland. Sweet to tonify Spleen Qi and nourish the Middle Burner, bland to gently leach out Dampness without harsh drying, with a light aromatic note from Sha Ren to awaken the Stomach.

Channels Entered

Ingredients

10 herbs

The herbs that make up Shen Ling Bai Zhu San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Ren Shen

Ren Shen

Ginseng root

Dosage 9 - 15g
Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys

Role in Shen Ling Bai Zhu San

Powerfully tonifies the Spleen and Stomach Qi, serving as the primary force to restore the weakened digestive function. As the chief Qi tonic, it addresses the root deficiency that underlies all the symptoms.
Bai Zhu

Bai Zhu

White Atractylodes rhizome

Dosage 9 - 15g
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach
Preparation Dry-fried (炒)

Role in Shen Ling Bai Zhu San

Strengthens the Spleen and dries Dampness. Works alongside Ren Shen and Fu Ling as the core trio (the formula's namesake herbs) to tonify Qi while resolving accumulated dampness in the digestive system.
Fu Ling

Fu Ling

Poria

Dosage 9 - 15g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Shen Ling Bai Zhu San

Leaches out Dampness through gentle diuresis while supporting the Spleen. Complements Bai Zhu's drying action by draining dampness downward through urination, ensuring that the Spleen's environment stays dry enough to function properly.
Deputies — Assists and enhances the King
Shan Yao

Shan Yao

Chinese yam

Dosage 9 - 15g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs, Kidneys

Role in Shen Ling Bai Zhu San

Reinforces the Spleen, tonifies the Lungs, and mildly astringes to help stop diarrhea. Its bland, nourishing quality supports digestion without creating stagnation, and it bridges the Spleen-Lung axis that this formula aims to strengthen.
Lian Zi

Lian Zi

Lotus seed

Dosage 6 - 9g
Temperature Neutral
Taste Sweet (甘 gān), Astringent (涩 sè)
Organ Affinity Spleen, Kidneys, Heart
Preparation Remove skin (去皮)

Role in Shen Ling Bai Zhu San

Tonifies the Spleen and has an astringent quality that helps consolidate the intestines and stop diarrhea. Also calms the spirit, addressing the restlessness and palpitations that can accompany Spleen Qi deficiency.
Bai Bian Dou

Bai Bian Dou

White hyacinth bean

Dosage 9 - 12g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach
Preparation Soaked in ginger juice, skin removed, lightly stir-fried (姜汁浸,去皮,微炒)

Role in Shen Ling Bai Zhu San

Strengthens the Spleen and resolves Dampness. Its mild, food-like quality gently supports the Spleen's transforming function and helps stop diarrhea without being overly drying.
Yi Yi Ren

Yi Yi Ren

Job's Tears seed

Dosage 6 - 9g
Temperature Cool
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Spleen, Stomach, Lungs
Preparation Stir-fried (炒)

Role in Shen Ling Bai Zhu San

Strengthens the Spleen and leaches out Dampness through the urine. Assists Fu Ling and Bai Zhu in resolving the accumulated dampness that is a key part of the pathomechanism.
Assistants — Supports or moderates other herbs
Sha Ren

Sha Ren

Amomum fruit

Dosage 3 - 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Spleen, Stomach, Kidneys
Preparation Crushed before use; added near end of decoction (后下) if used as decoction

Role in Shen Ling Bai Zhu San

Aromatically awakens the Spleen and transforms Dampness, while promoting Qi movement in the Middle Burner. Its warm, fragrant nature counteracts the tendency of the many tonifying herbs in this formula to cause stagnation, ensuring that supplementation does not create bloating.
Jie Geng

Jie Geng

Balloon flower root

Dosage 3 - 6g
Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs
Preparation Stir-fried until deep yellow (炒令深黄色)

Role in Shen Ling Bai Zhu San

Opens and diffuses the Lung Qi, serving as the 'boat' that carries the formula's actions upward. By directing Qi to the Lungs, it embodies the 'nourishing Earth to generate Metal' (培土生金) principle and helps regulate the water passages from above.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Preparation Honey-processed (炙)

Role in Shen Ling Bai Zhu San

Tonifies the Spleen, harmonizes the Middle Burner, and moderates and harmonizes all the other herbs in the formula. Its sweet flavor directly benefits the Spleen while ensuring the prescription works as a unified whole.

Why This Combination Works

How the herbs in Shen Ling Bai Zhu San complement each other

Overall strategy

This formula addresses Spleen deficiency complicated by Dampness accumulation. The prescription strategy is to tonify the Spleen Qi as the root treatment while simultaneously resolving Dampness and promoting Qi movement, so that supplementation does not create further stagnation. A secondary aim is to benefit the Lungs through the 'nourishing Earth to generate Metal' (培土生金) principle.

King herbs

Ren Shen (Ginseng), Bai Zhu (White Atractylodes), and Fu Ling (Poria) form the core trio that gives the formula its name. These three herbs, together with Gan Cao, constitute Si Jun Zi Tang (Four Gentlemen Decoction), the foundational Spleen Qi tonic. Ren Shen powerfully replenishes the depleted Spleen Qi. Bai Zhu strengthens the Spleen while drying internal Dampness. Fu Ling drains Dampness downward through gentle diuresis while also supporting the Spleen. Together, they tackle both sides of the problem: the underlying Qi deficiency and the Dampness it produces.

Deputy herbs

Shan Yao, Lian Zi, Bai Bian Dou, and Yi Yi Ren reinforce the Kings from complementary angles. Shan Yao and Lian Zi assist in strengthening the Spleen while adding mild astringency to firm the stools and stop diarrhea. Bai Bian Dou and Yi Yi Ren bolster the dampness-resolving action of Bai Zhu and Fu Ling, further draining accumulated moisture while nourishing the Spleen. This group of Deputies is notably food-like and mild, reflecting the formula's gentle, long-term therapeutic character.

Assistant herbs

Sha Ren (reinforcing assistant) aromatically transforms Dampness and moves Qi in the Middle Burner. This is critical because the many sweet, tonifying herbs in the formula could easily cause stagnation and bloating. Sha Ren prevents this by keeping the digestive Qi flowing. Jie Geng (reinforcing assistant) opens and lifts the Lung Qi, serving as the 'boat' (舟楫) that carries the formula's effects upward. By directing the pure essence of food and drink up to the Lungs, it embodies the 'nourishing Earth to generate Metal' principle, simultaneously supporting Lung function and helping to regulate the body's water metabolism from above.

Envoy herbs

Zhi Gan Cao (honey-processed Licorice) warms and supplements the Middle Burner while harmonizing all the other herbs in the formula. In the original text, Da Zao (jujube) decoction is used to take the powder, further supplementing the Spleen and serving as a gentle vehicle for the medicine.

Notable synergies

The pairing of Sha Ren and Jie Geng is particularly notable: Sha Ren moves Qi in the Middle Burner while Jie Geng lifts Qi to the Upper Burner, together restoring the proper ascending and descending of Qi that Spleen deficiency disrupts. The overall design carefully balances tonification with Dampness resolution (补中有渗), ensuring the formula supplements without creating heaviness and drains without depleting.

How to Prepare

Traditional preparation instructions for Shen Ling Bai Zhu San

The original source text describes this as a powder (散剂). All ten herbs are ground into a fine powder and mixed well. The traditional dosage is approximately 6g of the powder per serving, taken with a warm jujube (Da Zao) decoction two to three times daily. For children, the dose is reduced according to age.

In modern clinical practice, the formula is also commonly prepared as a decoction (水煎剂): combine the herbs in the proportions given, soak in approximately 500ml of water for 30 minutes, then bring to a boil and simmer on low heat for 30 minutes. Strain the liquid, then add water for a second decoction. Combine both extractions and divide into two doses, taken warm in the morning and evening. The formula is also widely available as prepared granules (6-9g per dose, 2-3 times daily) and as pills (参苓白术丸).

Common Modifications

How practitioners adapt Shen Ling Bai Zhu San for specific situations

Added
Gan Jiang

6-9g, warms the Middle Burner and dispels Cold

Rou Gui

3-6g, warms the interior and assists Yang

When Spleen deficiency is complicated by interior Cold causing cramping abdominal pain and watery diarrhea, adding Gan Jiang and Rou Gui warms the Middle Burner and restores Yang, directly addressing the Cold that the base formula's mild herbs cannot resolve.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Shen Ling Bai Zhu San should not be used or requires extra caution

Caution

Yin deficiency with Heat signs (dry mouth, night sweats, red tongue with little coating). The formula's Dampness-draining and Qi-tonifying herbs can further deplete Yin fluids.

Caution

Acute external pathogen invasion (colds, flu in the early stage). Tonifying the Spleen during a Wind-Cold or Wind-Heat attack can trap the pathogen inside the body.

Caution

Diarrhea or digestive complaints caused by Damp-Heat or food stagnation with Heat signs (foul-smelling stools, burning sensation, yellow greasy tongue coating). This formula is designed for cold-deficiency patterns, not excess Heat.

Caution

Patients with hormone-sensitive breast cancer should exercise caution, as the formula contains Gan Cao (Licorice) and Shan Yao (Chinese Yam), which have estrogenic properties, though evidence on whether the formula acts as a phytoestrogen is lacking.

Avoid

Discontinue at least one week before surgery, as the formula contains Ren Shen (Ginseng), which may increase bleeding risk during surgical procedures.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe during pregnancy when used under professional guidance, as the formula contains gentle tonifying and Dampness-draining herbs with no harsh moving or draining substances. However, caution is warranted because Ren Shen (Ginseng) is a strong Qi tonic that may not be appropriate for all pregnancy constitutions, and Yi Yi Ren (Coix Seed) is traditionally noted with caution in pregnancy due to its slippery, descending nature in some classical texts, though at the moderate doses used in this formula the risk is considered low. A qualified practitioner should assess individual suitability.

Breastfeeding

Generally considered compatible with breastfeeding. The formula's herbs are mild, tonifying substances, many of which (Shan Yao, Yi Yi Ren, Lian Zi, Bai Bian Dou) are also used as common foods. Ren Shen (Ginseng) is the component most likely to transfer bioactive compounds through breast milk. Gan Cao (Licorice) in large doses can cause fluid retention, but at the amounts used in this formula, this is unlikely to be clinically significant. Nonetheless, nursing mothers should consult a qualified practitioner, and the infant should be monitored for any changes in feeding or bowel habits.

Children

Shen Ling Bai Zhu San has a long history of pediatric use. The original text in the Tai Ping Hui Min He Ji Ju Fang specifically states that children's doses should be adjusted according to age. The formula is well-suited to children because its herbs are mild, many of them being common foods (yam, lotus seed, coix seed, white hyacinth bean). It is frequently used in modern Chinese pediatric practice for childhood diarrhea, poor appetite, malnutrition (gan ji), and failure to thrive due to Spleen deficiency. General dosage guidance: children under 3 years may take one-quarter to one-third of the adult dose; children aged 3-6 may take one-third to one-half; children aged 6-12 may take one-half to two-thirds. A qualified practitioner should determine exact dosing. When substituting for Ren Shen, pediatric practitioners in China commonly use Tai Zi Shen (Pseudostellaria root), which is gentler and also nourishes Yin.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Shen Ling Bai Zhu San

Gan Cao (Licorice) in this formula has the broadest interaction potential. Glycyrrhizin, a major compound in licorice, can cause potassium loss and sodium retention. This may interfere with antihypertensive medications, diuretics (especially potassium-depleting types like thiazides and loop diuretics, potentially worsening hypokalemia), cardiac glycosides (e.g. digoxin, where hypokalemia increases toxicity risk), and corticosteroids (additive mineralocorticoid effects).

Ren Shen (Ginseng) has complex interactions with warfarin and other anticoagulants. Published evidence is mixed, with some reports suggesting ginseng may reduce warfarin's anticoagulant effect. Ginseng may also interact with hypoglycemic agents (insulin, metformin) by potentiating blood-sugar-lowering effects, and with MAO inhibitors. Patients on any anticoagulant or antiplatelet therapy should exercise caution.

Shan Yao (Chinese Yam) and Gan Cao both have estrogenic properties, which may theoretically interact with hormone therapies, oral contraceptives, or selective estrogen receptor modulators (SERMs), though clinical evidence for the formula as a whole acting as a phytoestrogen is lacking.

Usage Guidance

Practical advice for getting the most out of Shen Ling Bai Zhu San

Best time to take

30 minutes before meals, or on an empty stomach, to optimize absorption and support the Spleen's digestive function. Traditionally taken twice daily (morning and early afternoon).

Typical duration

Typically taken for 2-8 weeks for chronic digestive complaints, then reassessed. May be used longer-term (months) for constitutional Spleen deficiency under practitioner guidance, as the formula is mild and well-tolerated.

Dietary advice

Avoid cold, raw, and greasy foods while taking this formula, as they burden the already weakened Spleen and counteract the formula's warming, tonifying action. This includes ice-cold drinks, salads, raw fruits in excess, deep-fried foods, and heavy dairy products. Favor warm, easily digestible, lightly cooked foods that support the Spleen: congee (rice porridge), cooked root vegetables, soups with ingredients like yam, lotus seed, coix seed (Job's tears), and white lentils (many of the same ingredients found in the formula itself). Avoid excessively sweet or sticky foods, as these generate further Dampness. Small, regular meals are preferable to large heavy ones.

Shen Ling Bai Zhu San originates from Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方) Sòng dynasty, 1107 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Shen Ling Bai Zhu San and its clinical use

Original text from the Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方):

「治脾胃虚弱,饮食不进,多困少力,中满痞噎,心忪气喘,呕吐泄泻及伤寒咳噫。此药中和不热,久服养气育神,醒脾悦色,顺正辟邪。」

Translation: "Treats Spleen and Stomach weakness with inability to take in food, excessive drowsiness and lack of strength, fullness and obstruction in the middle, palpitations and shortness of breath, vomiting and diarrhea, and coughing with belching from Cold damage. This medicine is balanced and not heating. Long-term use nourishes Qi and cultivates the spirit, awakens the Spleen and brings a healthy complexion, supports the upright and dispels pathogenic influences."

Commentary attributed to later scholars on the formula's mechanism:

「足太阴阳明药也,治脾胃者,补其虚,除其湿,引其滞,调其气而已。」

Translation: "This is a medicine for the Foot Tai Yin and Yang Ming channels. To treat the Spleen and Stomach, one merely supplements the deficiency, eliminates the Dampness, guides out the stagnation, and regulates the Qi."

Historical Context

How Shen Ling Bai Zhu San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Shen Ling Bai Zhu San first appeared in the Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方), a government-compiled formulary of the Song Dynasty (originally published around 1078-1085 CE, with later additions). This was one of China's earliest official pharmacopeias, produced under imperial authority to standardize medical prescriptions for use in government-run pharmacies throughout the empire. The formula was originally prepared as a powder (san), with each dose taken mixed into a jujube (date) decoction.

The formula is recognized as a refined expansion of the foundational Si Jun Zi Tang (Four Gentlemen Decoction), the most basic Qi-tonifying formula. By adding Shan Yao, Bai Bian Dou, Lian Zi, Yi Yi Ren, Sha Ren, and Jie Geng to the four-herb base of Ren Shen, Bai Zhu, Fu Ling, and Gan Cao, the Song-era physicians created a more comprehensive formula that simultaneously addresses Dampness and supports the Lungs. Later practitioners sometimes added Chen Pi (tangerine peel) to enhance its Qi-regulating effect. Over the centuries, its clinical application expanded well beyond its original digestive indications to include respiratory conditions, pediatric malnutrition, chronic nephritis, and numerous other disorders rooted in Spleen deficiency. It remains one of the most widely prescribed classical formulas in modern Chinese clinical practice and is listed in the Chinese Pharmacopoeia.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Shen Ling Bai Zhu San

1

Systematic review and meta-analysis of Shenling Baizhu San for chronic diarrhea in adults (2022)

Wang H, Hou YN, Yang M, Feng Y, Zhang YL, Smith CM, Hou W, Mao JJ, Deng G. Integrative Cancer Therapeutics. 2022; 21: 15347354221081214.

This systematic review analyzed 14 RCTs involving 1,158 patients with ulcerative colitis, chronic diarrhea, and diarrhea-predominant IBS. The pooled results showed that Shen Ling Bai Zhu San, alone or combined with conventional medicine, significantly improved patient-reported satisfaction compared to conventional medicine alone. Analysis of 9 trials also showed that the formula did not increase the risk of adverse effects compared to controls.

2

Systems pharmacology and microbiome dissection of Shen Ling Bai Zhu San for IBD (2019)

Lv WJ, Liu C, Li YF, Chen WQ, Li ZQ, Li Y, et al. Oxidative Medicine and Cellular Longevity. 2019; 2019: 8194804.

This preclinical study used systems pharmacology and gut microbiome analysis to investigate how the formula works against inflammatory bowel disease. The researchers identified multiple active compounds and their molecular targets, and demonstrated that the formula modulates gut microbiota composition while acting on multiple inflammatory and immune-related signaling pathways, supporting its use as a multiscale treatment strategy for IBD.

3

Chinese herbal formula Shen-ling-bai-zhu-san for chronic gastritis: systematic review, meta-analysis and network pharmacology (2022)

Published in World Journal of Gastroenterology. 2022; PMC9476852.

This study combined a systematic review of clinical trials with network pharmacology analysis. The meta-analysis found that the formula may be useful in treating chronic gastritis, with pooled data showing lower recurrence rates and superior H. pylori negative conversion rates compared to conventional therapies. However, the overall quality of evidence was assessed as low, and the authors called for larger, higher-quality clinical trials.

PubMed
4

Pilot RCT of Samryungbaekchul-san combined with otilonium bromide for diarrhea-predominant IBS (2019)

Lee JH, Kim JI, Baeg MK, et al. Journal of Clinical Medicine. 2019; 8(10): 1558.

This Korean pilot randomized controlled trial evaluated the combination of SLBZS (known as Samryungbaekchul-san in Korean medicine) with otilonium bromide for diarrhea-predominant irritable bowel syndrome. The study provided preliminary evidence for the combination approach, though as a pilot study the sample size was limited.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.