Xiang Sha Liu Junzi Tang

Aucklandia and Amomum Six Gentlemen Decoction · 香砂六君子湯

Also known as: Xiang Sha Liu Jun Tang (香砂六君汤), Xiang Sha Liu Jun Zi Wan (香砂六君子丸, pill form)

A classical formula designed to strengthen weak digestion and relieve bloating, nausea, and abdominal discomfort caused by a weak Spleen and Stomach with dampness and stagnation. It builds upon the foundational Si Jun Zi Tang (Four Gentlemen Decoction) by adding herbs that move Qi and resolve phlegm, making it especially suited for people whose digestive weakness is accompanied by a feeling of fullness, poor appetite, and loose stools.

Origin Gǔ Jīn Míng Yī Fāng Lùn (古今名医方论, Ancient and Modern Famous Physicians' Formula Discussions), Volume 1, citing Ke Yunbo (柯韵伯) — Qīng dynasty, circa 1675 CE
Composition 8 herbs
Ren Shen
King
Ren Shen
Bai Zhu
Deputy
Bai Zhu
Fu Ling
Assistant
Fu Ling
Ban Xia
Assistant
Ban Xia
Chen Pi
Assistant
Chen Pi
Mu Xiang
Assistant
Mu Xiang
Sha Ren
Assistant
Sha Ren
Gan Cao
Envoy
Gan Cao
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Xiang Sha Liu Junzi Tang is designed to correct these specific patterns.

Why Xiang Sha Liu Junzi Tang addresses this pattern

When the Spleen is too weak to properly transform food and fluids, unprocessed dampness accumulates and condenses into phlegm. This phlegm-dampness obstructs the middle burner, further impairing the Spleen's already compromised function and creating a vicious cycle. Simultaneously, the weakened Spleen cannot circulate Qi smoothly, so Qi stagnation develops on top of the deficiency. The patient experiences the characteristic combination of deficiency signs (fatigue, poor appetite, pale tongue) alongside excess signs (bloating, fullness, nausea, greasy tongue coating). This formula directly breaks this cycle: Ren Shen, Bai Zhu, Fu Ling, and Zhi Gan Cao rebuild the Spleen's foundational strength; Ban Xia and Chen Pi dissolve the accumulated phlegm-dampness; and Mu Xiang and Sha Ren restore Qi circulation to relieve stagnation. The formula addresses both root (deficiency) and branch (stagnation and phlegm) simultaneously.

A practitioner would look for one or more of these signs

Abdominal Pain

Epigastric and abdominal distension that worsens after eating

Poor Appetite

Reduced appetite or aversion to food

Nausea

Nausea or vomiting of clear or phlegmy fluid

Loose Stools

Loose, unformed stools

Eye Fatigue

Tiredness and lack of physical energy

Abdominal Pain

Dull epigastric or abdominal pain that improves with warmth and pressure

Belching

Frequent belching or acid reflux

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Xiang Sha Liu Junzi Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, functional dyspepsia is understood primarily through the lens of Spleen and Stomach dysfunction. The Spleen is responsible for transforming food into usable nourishment and transporting it throughout the body. The Stomach receives food and "ripens" it, then sends the turbid residue downward. When these paired organs become weakened, the entire digestive process breaks down. Food sits undigested, fluids fail to be transformed and accumulate as dampness or phlegm, and Qi stagnates in the middle burner. This produces the hallmark symptoms of fullness, bloating, nausea, and epigastric discomfort that define functional dyspepsia. The condition is classified under the TCM categories of "epigastric pain" (胃痛 wèi tòng) and "focal distension" (痞满 pǐ mǎn).

Why Xiang Sha Liu Junzi Tang Helps

Xiang Sha Liu Jun Zi Tang is considered a primary formula for functional dyspepsia with Spleen deficiency pattern in Chinese clinical practice. Its dual action of tonifying Spleen Qi (through Ren Shen, Bai Zhu, Fu Ling, and Zhi Gan Cao) while simultaneously moving Qi and resolving dampness (through Mu Xiang, Sha Ren, Ban Xia, and Chen Pi) directly addresses both the root cause and the symptoms of the condition. Mu Xiang and Sha Ren specifically relieve the Qi stagnation responsible for epigastric pain and distension, while Ban Xia descends rebellious Stomach Qi to control nausea. Modern pharmacological research suggests the formula improves gastrointestinal motility, restores mitochondrial function in gut smooth muscle, and regulates brain-gut axis signaling through neuropeptides like ghrelin and cholecystokinin. Multiple meta-analyses of randomized controlled trials have found it more effective than prokinetic drugs for symptom improvement in functional dyspepsia.

Also commonly used for

Peptic Ulcer

Gastric and duodenal ulcers with Qi deficiency and cold pattern

Gastroparesis

Including diabetic gastroparesis

Gastric Prolapse

Gastroptosis due to Spleen Qi sinking

Chronic Diarrhea

Due to Spleen deficiency with dampness

Nausea

Chemotherapy-induced nausea and gastrointestinal side effects

Acid Reflux

With underlying Spleen-Stomach Qi deficiency

Loss Of Appetite

Chronic poor appetite from Spleen Qi deficiency

What This Formula Does

Every TCM formula has a specific set of actions — here's what Xiang Sha Liu Junzi Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Xiang Sha Liu Junzi Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Xiang Sha Liu Junzi Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Xiang Sha Liu Junzi Tang works at the root level.

This formula addresses a condition where the Spleen and Stomach have become weak in their core functions of transforming food and drink and transporting nutrients throughout the body. When these organs lose vitality, three problems tend to arise together, each making the others worse.

First, because the Spleen lacks the strength to properly transform fluids, moisture accumulates and thickens into Phlegm and turbid Dampness in the middle part of the torso. Second, without adequate Qi to drive the digestive process, the normal downward movement of the Stomach and the upward lifting function of the Spleen both stall, resulting in Qi stagnation. This stagnation creates a feeling of bloating, fullness, and pressure in the upper abdomen. Third, the combination of weak Qi, stagnant fluids, and blocked movement feeds a self-reinforcing cycle: Dampness further bogs down the Spleen, worsening the deficiency, which produces more Dampness. The classical term for this pattern is "Spleen-Stomach Qi deficiency with Phlegm obstruction and Qi stagnation" (脾胃气虚,痰阻气滞).

Patients caught in this cycle typically experience poor appetite or aversion to food, a sense of fullness or distension in the stomach area even without eating much, nausea or vomiting, loose stools, fatigue, and a pale tongue with a white greasy coating. The formula works by rebuilding the Spleen's Qi while simultaneously clearing away the Phlegm-Dampness and unblocking the stagnant Qi, breaking the vicious cycle from multiple angles at once.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly sweet and acrid (pungent) with mild bitter notes. Sweet from the tonifying herbs to nourish the Spleen, acrid and aromatic from Mu Xiang, Sha Ren, and Chen Pi to move Qi and transform Dampness.

Ingredients

8 herbs

The herbs that make up Xiang Sha Liu Junzi Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Ren Shen

Ren Shen

Ginseng root

Dosage 3 - 9g
Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys

Role in Xiang Sha Liu Junzi Tang

The chief herb for powerfully tonifying the Qi of the Spleen and Stomach, restoring the fundamental digestive capacity that drives the entire formula's therapeutic strategy. As the core of the underlying Si Jun Zi Tang structure, it addresses the root deficiency.
Deputy — Assists and enhances the King
Bai Zhu

Bai Zhu

White Atractylodes rhizome

Dosage 6 - 12g
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach

Role in Xiang Sha Liu Junzi Tang

Strengthens the Spleen and dries dampness, directly supporting Ren Shen in tonifying the middle burner while addressing the accumulation of dampness that impairs digestive function.
Assistants — Supports or moderates other herbs
Fu Ling

Fu Ling

Poria

Dosage 6 - 12g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Xiang Sha Liu Junzi Tang

Promotes water metabolism and leaches out dampness through the urinary pathway, while gently strengthening the Spleen. Works alongside Bai Zhu to address the dampness component from a complementary angle.
Ban Xia

Ban Xia

Pinellia tuber

Dosage 3 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs
Preparation Use processed form (法半夏 or 姜半夏) to reduce toxicity

Role in Xiang Sha Liu Junzi Tang

Dries dampness and transforms phlegm, while harmonizing the Stomach and directing rebellious Qi downward to stop nausea and vomiting. A key herb for resolving the phlegm-dampness that accumulates when the Spleen fails to transform fluids.
Chen Pi

Chen Pi

Tangerine peel

Dosage 3 - 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Spleen

Role in Xiang Sha Liu Junzi Tang

Regulates Qi flow and dries dampness, helping to prevent the tonifying herbs from creating stagnation. Its aromatic nature awakens the Spleen and its Qi-moving action relieves the chest and epigastric fullness.
Mu Xiang

Mu Xiang

Costus root

Dosage 2 - 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, San Jiao (Triple Burner), Gallbladder

Role in Xiang Sha Liu Junzi Tang

Strongly promotes the movement of Qi through the three burners, relieving pain and distension in the epigastrium and abdomen. Its warm, acrid nature breaks through Qi stagnation that accumulates when the Spleen is too weak to circulate Qi properly.
Sha Ren

Sha Ren

Amomum fruit

Dosage 2 - 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Spleen, Stomach, Kidneys
Preparation Crush before use; add in the final 5 minutes of decoction (后下) to preserve volatile oils

Role in Xiang Sha Liu Junzi Tang

Aromatically transforms dampness and warms the middle burner, while promoting Qi circulation between the Spleen and Kidney. Its fragrant warmth awakens a sluggish Spleen and stops vomiting and diarrhea.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 2 - 3g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Xiang Sha Liu Junzi Tang

Tonifies the Spleen Qi in its own right while harmonizing all the other herbs in the formula. Its sweet flavor supports the middle burner and moderates the drying and moving properties of the other ingredients.

Why This Combination Works

How the herbs in Xiang Sha Liu Junzi Tang complement each other

Overall strategy

This formula addresses the intertwined problem of Spleen Qi deficiency and Qi stagnation with phlegm-dampness obstruction. Its genius lies in simultaneously tonifying and moving: the tonifying herbs restore digestive power while the aromatic Qi-movers ensure that the tonics do not create further stagnation in an already sluggish system.

King herbs

Ren Shen (Ginseng) serves as the sole King herb, powerfully replenishing the Qi of the Spleen and Stomach. This is the root cause being treated: when Spleen Qi is deficient, the entire digestive system loses its ability to transform food and fluids, leading to the cascade of dampness, phlegm, and stagnation that produces the formula's target symptoms.

Deputy herbs

Bai Zhu reinforces the King by strengthening the Spleen with the added benefit of drying dampness. Where Ren Shen provides raw Qi power, Bai Zhu specifically targets the Spleen's ability to transport and transform, addressing the dampness that has already begun to accumulate.

Assistant herbs

Fu Ling (reinforcing assistant) supports the Spleen from a different angle by draining dampness downward through urination, complementing Bai Zhu's drying action. Ban Xia (reinforcing assistant) specifically targets phlegm that has already formed, dries dampness, and critically descends rebellious Stomach Qi to stop nausea and vomiting. Chen Pi (reinforcing assistant) regulates Qi and dries dampness, ensuring the tonic herbs do not cause stagnation. Mu Xiang and Sha Ren are the distinguishing additions that elevate this formula beyond Liu Jun Zi Tang. Mu Xiang (reinforcing assistant) powerfully moves Qi through all three burners, breaking through the stagnation that causes epigastric and abdominal pain and distension. Sha Ren (reinforcing assistant) aromatically awakens the Spleen and warms the middle burner, addressing both the cold and dampness aspects of the condition.

Envoy herbs

Zhi Gan Cao harmonizes all the ingredients, moderating the drying nature of herbs like Ban Xia and Bai Zhu while contributing its own gentle Spleen-tonifying quality. Its sweet flavor anchors the formula in the middle burner.

Notable synergies

The Ren Shen and Bai Zhu pairing is the classical Qi-and-dampness combination: one builds power, the other clears the path. Bai Zhu and Fu Ling together dry dampness from two directions (internal drying and downward draining). Mu Xiang and Sha Ren together provide a powerful one-two punch for Qi stagnation: Mu Xiang moves Qi broadly through the three burners while Sha Ren specifically warms and aromatizes the middle burner. Ban Xia and Chen Pi form the core of Er Chen Tang, the foundational phlegm-resolving combination. The overall design pairs four tonifying herbs (Si Jun Zi Tang) with four Qi-regulating and phlegm-resolving herbs, creating the principle of "supplementing without stagnating" (补而不滞).

How to Prepare

Traditional preparation instructions for Xiang Sha Liu Junzi Tang

Add the eight herbs (except Sha Ren) to approximately 600 ml of water along with 2-3 slices of fresh ginger. Bring to a boil, then simmer on low heat for 20-30 minutes. Add the Sha Ren (crushed) during the final 5 minutes of decoction, as prolonged boiling destroys its volatile aromatic oils. Strain and divide into two portions. Take warm, 30 minutes before meals, twice daily.

In the original text, the herbs were prepared as a single dose (一剂) decocted with fresh ginger in water.

Common Modifications

How practitioners adapt Xiang Sha Liu Junzi Tang for specific situations

Added
Wu Zhu Yu

3-6g, warms the Stomach and disperses cold to relieve pain

Gao Liang jiang

3-6g, strongly warms the middle burner and stops pain

When cold congeals in the Stomach causing intense cramping pain relieved by warmth, Wu Zhu Yu and Gao Liang Jiang provide additional warming and pain-relieving power beyond what Sha Ren and Mu Xiang alone can achieve.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Xiang Sha Liu Junzi Tang should not be used or requires extra caution

Avoid

Yin deficiency with Heat signs (dry mouth, night sweats, red tongue with little coating). This formula is warm and drying in nature, which would further deplete Yin fluids and aggravate Heat.

Avoid

Stomach Heat or Damp-Heat patterns (burning epigastric pain, acid reflux with bitter taste, yellow greasy tongue coating). The warming herbs would intensify the Heat.

Caution

Constipation due to dryness or fluid depletion. The drying nature of Ban Xia, Bai Zhu, and Chen Pi may worsen dry constipation.

Caution

Acute exterior conditions (common cold, influenza). Tonifying the interior while a pathogen occupies the exterior may trap the pathogen inside the body.

Caution

Patients with active bleeding or those on anticoagulant therapy should use caution, as Mu Xiang and Sha Ren strongly move Qi and could theoretically influence circulation.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Ban Xia (Pinellia) is traditionally classified as a pregnancy-cautioned herb due to its potential to cause uterine stimulation, though the processed forms (Fa Ban Xia, Jiang Ban Xia) used in this formula are significantly milder than the raw form. Mu Xiang and Sha Ren strongly move Qi, which warrants additional care. Sha Ren, interestingly, is used in some classical formulas to calm a restless fetus in Spleen deficiency, so it is not itself contraindicated. Overall, the formula is not absolutely contraindicated but should only be prescribed by a qualified practitioner who can assess the specific clinical situation. Avoid in early pregnancy without professional guidance.

Breastfeeding

Generally considered compatible with breastfeeding when used appropriately and under professional guidance. The herbs in this formula are mostly gentle tonifying and Qi-moving substances without known toxicity concerns regarding transfer through breast milk. Ren Shen (Ginseng) may mildly stimulate and could theoretically affect a sensitive infant, so practitioners sometimes substitute Dang Shen (Codonopsis) as a gentler alternative. Gan Cao (Licorice) in moderate doses is not expected to cause issues but should not be used in excessive amounts during lactation. No specific adverse effects on milk production or infant health have been reported in the classical literature. Consult a qualified practitioner before use.

Children

This formula can be used in children, particularly for pediatric digestive complaints such as poor appetite, chronic loose stools, and failure to thrive due to Spleen Qi deficiency. Dosage should be reduced proportionally based on age and body weight: roughly one-quarter to one-third of the adult dose for children under 6, and one-half for children aged 6-12. Ren Shen (Ginseng) is sometimes replaced with the milder Dang Shen (Codonopsis) in pediatric prescriptions. The formula should be prescribed by a qualified practitioner who can properly differentiate the pattern. Avoid prolonged use without reassessment, as children's constitutions change rapidly.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Xiang Sha Liu Junzi Tang

Gan Cao (Licorice): The glycyrrhizin in Gan Cao may cause potassium depletion and sodium/water retention. It can interact with corticosteroids (additive potassium loss), digoxin and other cardiac glycosides (hypokalemia increases toxicity risk), diuretics especially loop and thiazide types (compounded electrolyte imbalance), and antihypertensive medications (may counteract blood pressure lowering through fluid retention).

Ren Shen (Ginseng): May interact with warfarin and other anticoagulants (potential alteration of INR), hypoglycemic agents including insulin (additive blood sugar lowering), and MAO inhibitors (risk of overstimulation). Ginseng may also reduce the effectiveness of immunosuppressants due to its immune-modulating properties.

Ban Xia (Pinellia): The processed form used in this formula is low in toxicity, but it is traditionally considered incompatible with Wu Tou (Aconitum) preparations. No major documented pharmaceutical drug interactions, but the herb's gastrointestinal effects may theoretically alter absorption rates of orally administered drugs.

General note: As a formula that affects gastrointestinal motility and gastric function, it may alter the absorption rate or bioavailability of concurrently taken oral medications. It is advisable to separate the timing of this formula from pharmaceutical drugs by at least 1-2 hours.

Usage Guidance

Practical advice for getting the most out of Xiang Sha Liu Junzi Tang

Best time to take

30 minutes before meals, twice daily (morning and evening), taken warm.

Typical duration

Typically prescribed for 2-4 weeks for acute digestive complaints, or 4-8 weeks for chronic conditions such as chronic gastritis or functional dyspepsia, with periodic reassessment by a practitioner.

Dietary advice

Avoid cold and raw foods (salads, iced drinks, raw fruit in excess, sushi), as these burden an already weakened Spleen and Stomach. Reduce greasy, fried, and heavily rich foods, which generate more Dampness and Phlegm. Limit dairy products, sugar, and excessively sweet foods, which also tend to produce Dampness. Favor warm, cooked, easily digestible meals such as congee (rice porridge), soups, steamed vegetables, and well-cooked grains. Foods that gently support Spleen function are helpful: yam (shan yao), cooked lotus seed, millet, ginger, and jujube dates. Eat regular meals at consistent times rather than large irregular meals, and avoid overeating, which strains the already deficient digestive system.

Xiang Sha Liu Junzi Tang originates from Gǔ Jīn Míng Yī Fāng Lùn (古今名医方论, Ancient and Modern Famous Physicians' Formula Discussions), Volume 1, citing Ke Yunbo (柯韵伯) Qīng dynasty, circa 1675 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Xiang Sha Liu Junzi Tang and its clinical use

Ke Yunbo (柯韵伯), as recorded in Gu Jin Ming Yi Fang Lun (《古今名医方论》), Volume 1:

「经曰:壮者气行则愈,怯者着而为病。盖人在气交之中,因气而生,而生气总以胃气为本。」

"The classics say: in the strong, when Qi flows freely, illness resolves; in the weak, Qi stagnates and disease arises. People live amidst the interchange of Qi, are born from Qi, and the root of all vital Qi lies in the Stomach Qi."

「四君子气分之总方也,人参致冲和之气,白术培中宫,茯苓清治节,甘草调五脏,胃气既治,病安从来。然拨乱反正,又不能无为而治,必举夫行气之品以辅之,则补品不至泥而不行。」

"Si Jun Zi Tang is the master formula for the Qi aspect. Ren Shen brings harmonious Qi, Bai Zhu cultivates the Middle Palace, Fu Ling clears and regulates, Gan Cao harmonizes the five organs. Once Stomach Qi is restored, where can disease come from? Yet to set things right, one cannot govern through inaction alone. Qi-moving herbs must be enlisted as assistants, so that the tonifying herbs do not become sluggish and stagnant."

「故加陈皮以利肺金之逆气,半夏以疏脾土之湿气,而痰饮可除也。加木香以行三焦之滞气,缩砂以通脾肾之元气,膹郁可开也。四君得四辅,而补力倍宣;四辅有四君,而元气大振。」

"Chen Pi is added to redirect the rebellious Qi of the Lungs, Ban Xia to disperse the Dampness of the Spleen Earth, so that Phlegm and fluid accumulation can be eliminated. Mu Xiang is added to move stagnant Qi in the San Jiao, and Sha Ren to free the original Qi of the Spleen and Kidneys, so that congestion and obstruction can be opened. When the Four Gentlemen gain these four assistants, their tonifying power is doubly expressed; when the four assistants have the Four Gentlemen behind them, the original Qi is greatly invigorated."

Historical Context

How Xiang Sha Liu Junzi Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Xiang Sha Liu Jun Zi Tang first appeared in the Gu Jin Ming Yi Fang Lun (《古今名医方论》, Treatise on Famous Physicians' Formulas), compiled by the Qing dynasty physician Luo Mei (罗美) and published around 1675. The formula's accompanying discussion was authored by Ke Qin (柯琴, also known as Ke Yunbo 柯韵伯), one of the most influential Shang Han Lun commentators of the Qing era. Although the book bears Luo Mei's name as editor, the formula and its rationale belong to Ke Qin's clinical tradition.

The formula represents the final stage in a famous "therapeutic ladder" of Qi-tonifying formulas that evolved over centuries. It begins with Si Jun Zi Tang (Four Gentlemen Decoction), the foundational Qi-tonifying formula from the Song dynasty. Adding Chen Pi and Ban Xia produced Liu Jun Zi Tang (Six Gentlemen Decoction), which added Phlegm-resolving capacity. Xiang Sha Liu Jun Zi Tang then added Mu Xiang and Sha Ren to address the additional complication of Qi stagnation. Several variant versions of this formula also exist in other texts, including those found in the Zhang Shi Yi Tong (《张氏医通》), the Jing Yue Quan Shu (《景岳全书》), and the Zeng Bu Wan Bing Hui Chun (《增补万病回春》), each with slightly different compositions and clinical emphases.

In modern times, the formula has become one of the most widely used digestive formulas in Chinese clinical practice. It is commercially available as the patent medicine Xiang Sha Liu Jun Zi Wan (香砂六君子丸) and is commonly prescribed for chronic gastritis, functional dyspepsia, and as a preparatory treatment for patients who are "too weak to receive tonics" (虚不受补), helping restore digestive function before stronger supplementing formulas are introduced.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Xiang Sha Liu Junzi Tang

1

Efficacy and safety of Xiangsha Liujunzi granules for functional dyspepsia: A multi-center randomized double-blind placebo-controlled clinical study (RCT, 2017)

Lv L, Wang FY, Ma XX, et al. World Journal of Gastroenterology, 2017, 23(30): 5380-5390.

A rigorous multi-center, randomized, double-blind, placebo-controlled trial enrolled 216 patients diagnosed with functional dyspepsia (Rome III criteria) and Spleen-deficiency/Qi-stagnation syndrome. Patients received Xiangsha Liujunzi granules or placebo for 4 weeks. The formula group showed significant symptomatic improvement, particularly in postprandial fullness, bloating, early satiety, and epigastric pain, with no adverse effects reported.

PubMed
2

Chinese Herbal Medicine Liu Jun Zi Tang and Xiang Sha Liu Jun Zi Tang for Functional Dyspepsia: Meta-Analysis of Randomized Controlled Trials (Meta-analysis, 2012)

Xiao Y, Liu YY, Yu KQ, Ouyang MZ, Luo R, Zhao XS. Evidence-Based Complementary and Alternative Medicine, 2012, 2012: 936459.

A meta-analysis of 15 RCTs comparing Liu Jun Zi Tang and Xiang Sha Liu Jun Zi Tang with prokinetic drugs (domperidone, cisapride, mosapride) for functional dyspepsia. XSLJZT showed a significantly higher rate of symptom improvement compared to prokinetics (OR 2.63, 95% CI 1.72-4.03). No adverse events were reported in any herbal treatment group across all trials.

PubMed
3

Efficacy and safety of Xiangsha liujunzi decoction for functional dyspepsia: a systematic review and meta-analysis (Systematic review/Meta-analysis, 2024)

Wang Y, et al. Frontiers in Pharmacology, 2024, 15: 1356899.

A systematic review and meta-analysis including 23 RCTs conducted exclusively in China evaluated Xiangsha Liujunzi decoction for functional dyspepsia. The analysis found the formula exhibited clinical effectiveness with no significant adverse events observed. However, the authors noted that the overall quality of the enrolled studies was low and called for more rigorous international trials.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.