Ke Xue Fang

Coughing of Blood Formula · 咳血方

A classical formula for coughing up blood caused by excessive Liver Fire flaring upward and scorching the Lungs. It clears Fire from the Liver, calms the Lungs, cools the Blood, and stops bleeding. Commonly used when coughing produces thick, sticky phlegm streaked with blood, accompanied by irritability, chest and rib-side pain, and a bitter taste in the mouth.

Origin Dan Xi Xin Fa (丹溪心法), by Zhu Danxi (朱丹溪) — Yuán dynasty, c. 1347 CE (published 1481 CE)
Composition 5 herbs
Qing Dai
King
Qing Dai
Zhi Zi
King
Zhi Zi
Gua Lou Ren
Deputy
Gua Lou Ren
Hai Fu Shi
Deputy
Hai Fu Shi
He Zi
Assistant
He Zi
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Ke Xue Fang is designed to correct these specific patterns.

Why Ke Xue Fang addresses this pattern

This is the primary pattern addressed by Ke Xue Fang. In this pattern, excessive Fire in the Liver flares upward along the Wood-Metal (Liver-Lung) relationship, a dynamic described as 'Wood Fire punishing Metal' (木火刑金). The Lungs are a delicate organ that cannot tolerate Heat. When Liver Fire invades, it scorches Lung fluids into thick Phlegm, disrupts the Lung's descending function (causing cough), and damages the fine network vessels (络脉) of the Lungs, causing blood to seep into the airways.

Ke Xue Fang addresses this by using Qing Dai and Zhi Zi to clear Liver Fire at its source and cool the Blood, Gua Lou Ren and Hai Fu Shi to clear the hot Phlegm that has already formed, and He Zi to astringe the Lungs and contain Lung Qi. The formula embodies the principle of 'embedding hemostasis within Fire-clearing' (寓止血于清热泻火之中): rather than using hemostatic herbs directly, it removes the cause of bleeding so that the Blood naturally returns to its proper pathways.

A practitioner would look for one or more of these signs

Hemoptysis

Coughing up blood-streaked phlegm

Cought With Sticky Phlegm

Thick, sticky phlegm that is difficult to expectorate

Chest Pain

Distending pain in the chest and rib-side (hypochondriac region)

Irritability

Irritability and restlessness with easily triggered anger

Bitter Taste In The Mouth

Bitter taste in the mouth, dry throat

Constipation

Constipation with red cheeks

Red Tongue

Red tongue with yellow coating, wiry and rapid pulse

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Ke Xue Fang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, hemoptysis (coughing up blood) can arise from several different internal imbalances. Ke Xue Fang specifically targets hemoptysis caused by Liver Fire invading the Lungs. The Liver stores Blood and governs the free flow of Qi. When Liver Qi stagnates (often from emotional stress, frustration, or anger), it can transform into Fire. This Fire rises along the Wood-Metal pathway, scorching the delicate Lung tissue and its network vessels. Blood then leaks from the damaged vessels into the airways, appearing as blood-streaked phlegm or frank hemoptysis. Key distinguishing signs are the co-occurrence of Liver symptoms (irritability, rib-side pain, bitter taste, wiry pulse) alongside Lung symptoms (cough, blood in phlegm).

Why Ke Xue Fang Helps

Ke Xue Fang treats hemoptysis by addressing its root cause rather than simply stopping the bleeding. Qing Dai and Zhi Zi clear the Liver Fire that is the underlying driver, while simultaneously cooling the Blood to help seal the damaged lung vessels. Gua Lou Ren and Hai Fu Shi dissolve the hot Phlegm that perpetuates coughing, since each bout of coughing further damages the fragile vessels. He Zi astringes the Lungs to calm the cough reflex. Clinical studies on bronchiectasis patients with hemoptysis have shown an overall effective rate of approximately 88% with modified versions of this formula.

Also commonly used for

Pulmonary Tuberculosis

With coughing blood, when Liver Fire pattern predominates

Chronic Bronchitis

With blood-streaked phlegm and signs of Liver Fire

Chronic Coughing

Persistent cough with thick phlegm and blood, worse with emotional stress

What This Formula Does

Every TCM formula has a specific set of actions — here's what Ke Xue Fang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Ke Xue Fang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Ke Xue Fang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Ke Xue Fang works at the root level.

This formula addresses a specific pattern known as "Liver Fire assaulting the Lungs" (肝火犯肺, Gan Huo Fan Fei), also called "Wood Fire tormenting Metal" (木火刑金, Mu Huo Xing Jin). In TCM's Five Element framework, the Liver (Wood) and Lungs (Metal) have a controlling relationship. When Liver Fire flares upward — often due to emotional frustration, anger, or prolonged stress — it rebels against the Lungs, scorching this delicate organ.

The Lungs are described as "an organ of utmost purity" (至清之脏) that cannot tolerate any disturbance. When fierce Liver Fire invades, it scorches the Lung's fluids, concentrating them into thick, sticky phlegm. The heat damages the fine blood vessels (络脉) in the Lungs, causing blood to seep into the airways and mix with phlegm. The result is the hallmark symptom: coughing up thick, sticky phlegm streaked with blood, accompanied by chest and rib-side pain, irritability, a bitter taste in the mouth, red cheeks, constipation, a red tongue with yellow coating, and a wiry, rapid pulse.

The key insight behind this formula is that the disease is located in the Lungs, but its root cause is in the Liver. Therefore, the primary treatment strategy is to "treat the root" (治本) by clearing Liver Fire. The formula embodies a principle called "stopping bleeding by clearing Heat and draining Fire" (寓止血于清热泻火之中): it contains no dedicated hemostatic (blood-stopping) herbs, because once the Fire causing the bleeding is extinguished, the blood returns to its proper channels on its own.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter and salty with some sour astringency — bitter to clear Fire and drain Heat downward, salty to soften hardness and dissolve Phlegm, sour-astringent to restrain the Lungs and stop cough.

Ingredients

5 herbs

The herbs that make up Ke Xue Fang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Kings — Main ingredient driving the formula
Qing Dai

Qing Dai

Indigo Naturalis

Dosage 6g
Temperature Cold
Taste Salty (咸 xián)
Organ Affinity Liver, Lungs
Preparation Water-processed (水飞, shuǐ fēi) to produce an ultra-fine powder

Role in Ke Xue Fang

Enters both the Liver and Lung channels. Clears Liver Fire, drains Heat, cools the Blood, and stops bleeding. As the primary King herb, it directly addresses the root cause of the pattern by clearing the Liver Fire that is scorching the Lungs.
Zhi Zi

Zhi Zi

Gardenia fruit

Dosage 9g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, San Jiao (Triple Burner)
Preparation Dry-fried until blackened (炒黑) to enhance Blood-level hemostatic action

Role in Ke Xue Fang

Bitter and cold, enters the Heart, Liver, and Lung channels. Clears Heat and drains Fire, cools the Blood, and eliminates irritability. When dry-fried until blackened (炒黑), it enters the Blood level and enhances its hemostatic action. Together with Qing Dai, it addresses the root by clearing Liver Fire and cooling Blood from multiple angles.
Deputies — Assists and enhances the King
Gua Lou Ren

Gua Lou Ren

Trichosanthes seed

Dosage 9g
Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Lungs, Stomach, Large Intestine
Preparation De-oiled (去油) to reduce its greasy, slippery nature

Role in Ke Xue Fang

Sweet and cold, enters the Lung channel. Clears Heat and transforms Phlegm, moistens the Lungs and stops coughing. Addresses the secondary pathology of hot Phlegm that forms when Liver Fire scorches Lung fluids. Without clearing the Phlegm, the cough persists and bleeding cannot stop.
Hai Fu Shi

Hai Fu Shi

Pumice

Dosage 9g
Temperature Cold
Taste Salty (咸 xián)
Organ Affinity Lungs, Kidneys

Role in Ke Xue Fang

Salty and cold. Clears Lung Heat, descends Fire, softens hardness, and dissolves Phlegm. Works alongside Gua Lou Ren to clear hot Phlegm from the Lungs. The original text uses 'Hai Fen' (sea powder), which Qing-dynasty physician Wang Ang later interpreted as Hai Fu Shi (pumice).
Assistant — Supports or moderates other herbs
He Zi

He Zi

Chebulic myrobalan fruit

Dosage 6g
Temperature Neutral
Taste Bitter (苦 kǔ), Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Lungs, Large Intestine
Preparation Baked (煨) and the flesh used (取肉)

Role in Ke Xue Fang

Bitter, sour, astringent, and neutral in nature. Enters the Lung and Large Intestine channels. Astringes and contains Lung Qi to stop coughing, while also transforming Phlegm. Provides a restraining balance to the formula's strongly clearing and draining herbs, preventing excessive dispersal of Lung Qi while ensuring the cough is controlled.

Why This Combination Works

How the herbs in Ke Xue Fang complement each other

Overall strategy

The core problem is Liver Fire flaring upward and attacking the Lungs, a pattern known as 'Wood insulting Metal' (木火刑金). The treatment principle is to clear and drain Liver Fire at its source so that the Lungs can naturally regain their descending function, Phlegm is resolved, and bleeding stops on its own. Notably, the formula contains no dedicated hemostatic herbs. As the Ming-dynasty physician Wu Kun observed, 'there are no Blood-stopping herbs because once the Fire is removed, the Blood stops on its own' (火去而血自止).

King herbs

Qing Dai (Natural Indigo) and Zhi Zi (Gardenia Fruit) jointly serve as King herbs. Qing Dai is salty and cold, entering both the Liver and Lung channels, making it uniquely suited to clear Liver Fire while simultaneously cooling the Blood in the Lungs. Zhi Zi is bitter and cold, clearing Heat from the Heart, Liver, and Lungs. When charred (炒黑), it specifically enters the Blood level to enhance hemostasis. Together they address the root cause from two angles: Qing Dai focuses on clearing Liver Fire and cooling Blood, while Zhi Zi descends Qi, drains Fire, and resolves irritability.

Deputy herbs

Gua Lou Ren (Trichosanthes Seed) and Hai Fu Shi (Pumice) serve as Deputies, targeting the secondary pathology of hot Phlegm. When Liver Fire scorches Lung fluids, the fluids congeal into thick, sticky Phlegm. Gua Lou Ren moistens the Lungs and transforms Phlegm, while Hai Fu Shi softens hardness and dissolves stubborn Phlegm. Together they ensure that Phlegm is cleared, because as long as Phlegm remains, coughing continues, and as long as coughing continues, bleeding cannot fully stop.

Assistant herbs

He Zi (Chebula Fruit) is the lone Assistant, serving a restraining role. The formula is dominated by cold, clearing, and descending herbs, which effectively purge Fire but risk over-dispersing Lung Qi. He Zi is astringent and gently contains Lung Qi, preventing excessive leakage while also helping to stop the cough. Its neutral temperature does not conflict with the cold nature of the other ingredients.

Notable synergies

The pairing of Qing Dai and Zhi Zi exemplifies the strategy of 'treating the root to resolve the branch' (治本以消标). By targeting the Liver (the root) and the Lungs (the branch) simultaneously, they ensure that Fire is drained at its source while the damaged Lung network vessels are given a chance to heal. The combination of clearing herbs (Qing Dai, Zhi Zi) with Phlegm-resolving Deputies (Gua Lou Ren, Hai Fu Shi) and an astringent Assistant (He Zi) creates a balanced formula that drains without dispersing excessively and stops bleeding without trapping pathological factors.

How to Prepare

Traditional preparation instructions for Ke Xue Fang

Grind all ingredients into a fine powder. Mix with honey and a small amount of fresh ginger juice to form pills. The traditional method calls for slowly dissolving one pill (approximately 5g) in the mouth (噙化, qín huà). This slow dissolution allows the medicinals to coat and soothe the throat and upper airways directly.

In modern clinical practice, this formula is also commonly prepared as a decoction: combine the herbs in the proportions given (adjusting dosages as appropriate) and decoct in water. It may also be taken as a powder in 9g doses.

Common Modifications

How practitioners adapt Ke Xue Fang for specific situations

Added
Tian Men Dong

9-12g, nourishes Lung Yin and generates fluids

Mu Dan Pi

6-9g, cools Blood and clears deficiency Heat

When prolonged Liver Fire has begun to consume Lung Yin, adding Yin-nourishing and Blood-cooling herbs prevents further damage and supports recovery.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Ke Xue Fang should not be used or requires extra caution

Avoid

Lung-Kidney Yin deficiency patterns. This formula is a cold, descending formula that clears excess Heat. It is not appropriate when coughing blood arises from Yin deficiency with deficiency-Fire, as there is no true excess Liver Fire to clear.

Avoid

Spleen deficiency with loose stools. The formula's cold nature (Qing Dai, Zhi Zi, Gua Lou Ren) and the lubricating effect of Gua Lou Ren may worsen diarrhea and further damage Spleen Yang.

Avoid

Wind-Cold cough or cough with thin, white, watery phlegm (Cold-Phlegm). This formula targets Heat and Fire, not Cold patterns. Using it for Cold-type cough could trap the Cold pathogen and worsen the condition.

Avoid

Massive or life-threatening hemoptysis. While this formula addresses coughing blood from Liver Fire, any severe or rapidly worsening bleeding requires urgent medical evaluation and should not be managed with herbal medicine alone.

Caution

Prolonged use without reassessment. Because the formula is entirely cold and descending with no tonifying herbs, extended use may injure the Spleen and Stomach or deplete the body's Qi.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Qing Dai (Indigo Naturalis) is cold in nature and traditionally considered potentially harsh during pregnancy. Gua Lou Ren (Trichosanthes seed) has a lubricating, downward-moving action that may theoretically stimulate the bowels and uterus. Zhi Zi (Gardenia) is bitter and cold, and high doses of cold, descending herbs are generally avoided in pregnancy due to risk of disturbing the fetus. This formula should only be considered during pregnancy if clearly indicated and prescribed by a qualified practitioner, with careful monitoring.

Breastfeeding

Caution is advised during breastfeeding. Qing Dai (Indigo Naturalis) contains indigo and indirubin, which are biologically active compounds that may transfer into breast milk. Zhi Zi (Gardenia) is strongly cold and bitter, and its cooling properties could theoretically affect the nursing infant's digestion. The formula's overall cold nature may reduce milk production in some individuals, as cold herbs can inhibit the warm Qi needed for lactation. If use is necessary, it should be under professional guidance, with close observation of the infant for signs of digestive upset or loose stools.

Children

Ke Xue Fang may be used in children with appropriate dose reductions, but only under professional supervision. The formula's cold, descending nature requires particular caution in pediatric patients, whose digestive systems are considered immature and vulnerable to cold damage. Dosages should typically be reduced to one-third to one-half of adult doses depending on age and body weight. It is not suitable for very young children (under age 3) due to the strong cold properties. Duration of use should be kept short, and the child's appetite and stool quality monitored closely for signs of Spleen damage.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Ke Xue Fang

Anticoagulants and antiplatelet agents (warfarin, heparin, aspirin, clopidogrel): While this formula does not contain strong Blood-moving herbs, its mechanism involves clearing Heat from the Blood. In patients already on anticoagulant therapy, combined use should be carefully monitored, as the underlying bleeding condition may be complex.

Antihypertensive medications: Zhi Zi (Gardenia) has demonstrated hypotensive effects in pharmacological studies. Combined use with antihypertensive drugs may potentiate blood pressure lowering.

Gua Lou Ren (Trichosanthes seed): Trichosanthes-derived compounds have been studied for various bioactivities. According to the traditional incompatibility principle (十八反), Gua Lou is listed as incompatible with Wu Tou (Aconite), so concurrent use of aconite-containing preparations should be strictly avoided.

Hepatotoxicity considerations: Zhi Zi (Gardenia) has been associated with potential hepatotoxicity at high doses or with prolonged use in some pharmacological reports. Patients taking other hepatotoxic medications should use this formula with caution and monitoring.

Usage Guidance

Practical advice for getting the most out of Ke Xue Fang

Best time to take

30 minutes after meals, 2–3 times daily. The original pill form was designed to be dissolved slowly in the mouth (噙化) between meals.

Typical duration

Acute use: typically 5–10 days until bleeding stops and cough improves, then reassess and consider switching to a nourishing follow-up formula.

Dietary advice

While taking this formula, avoid spicy, hot, fried, and greasy foods, as these generate internal Heat and can worsen Liver Fire and Phlegm-Heat. Alcohol and tobacco should be strictly avoided, as they inflame the Lungs and aggravate bleeding. Avoid shellfish and other "stimulating" (发物) foods that may trigger or worsen bleeding. Favor cooling, moistening foods such as pears, lotus root, water chestnuts, white fungus (tremella), mung beans, and fresh vegetables. Light, easily digestible meals help protect the Spleen and Stomach from the formula's cold nature.

Ke Xue Fang originates from Dan Xi Xin Fa (丹溪心法), by Zhu Danxi (朱丹溪) Yuán dynasty, c. 1347 CE (published 1481 CE)

Classical Texts

Key passages from the classical Chinese medical texts that first described Ke Xue Fang and its clinical use

Original Source — Dan Xi Xin Fa (《丹溪心法》), Volume 2, Chapter 19 "Ke Xue" (Coughing Blood):

The formula is listed under the chapter on coughing blood (咳血十九), with the terse notation: "咳血" ("Coughing blood"). The original text gives the composition — Qing Dai, He Zi, Gua Lou Ren, Hai Fen, Shan Zhi Zi — and instructs to grind into powder, form pills with honey and ginger juice, and dissolve slowly in the mouth.


Wu Kun, Yi Fang Kao (《医方考》), Volume 3, Blood Pattern Chapter (血证门):

"咳嗽痰血者,此方蜜丸噙化。肺者,至清之脏,纤芥不容,有气有火则咳,有痰有血则嗽。咳者有声之名,嗽者有物之义也。青黛、山栀所以降火,瓜蒌、海粉所以行痰,诃子所以敛肺。然而无治血之药者,火去而血自止也。"

Translation: "For cough with bloody phlegm, this formula is made into honey pills to be dissolved slowly in the mouth. The Lungs are an organ of utmost purity that cannot tolerate the slightest impurity. When there is Qi and Fire, there is cough; when there is phlegm and blood, there is expectoration. 'Cough' refers to the sound, 'expectoration' refers to the substance. Qing Dai and Shan Zhi Zi bring down Fire; Gua Lou and Hai Fen move phlegm; He Zi restrains the Lungs. Yet there is no herb specifically to stop bleeding — because once the Fire is gone, the blood naturally stops on its own."

Historical Context

How Ke Xue Fang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Ke Xue Fang originates from the Dan Xi Xin Fa (《丹溪心法》), a work compiled by the disciples of the great Yuan Dynasty physician Zhu Danxi (朱丹溪, also known as Zhu Zhenheng 朱震亨, 1281–1358). Zhu Danxi was one of the four great masters of the Jin-Yuan medical reform era, famous for his doctrine that "Yang is always in excess, Yin is always insufficient" (阳常有余,阴常不足). His emphasis on Fire as a major cause of disease and his skill in treating bleeding disorders through clearing Heat rather than simply staunching blood are reflected perfectly in this formula's design.

The original formula used "Hai Fen" (海粉, literally "sea powder," a processed marine substance) as one of its ingredients. During the Qing Dynasty, the physician Wang Ang (汪昂), author of the influential Yi Fang Ji Jie (《医方集解》), substituted Hai Fu Shi (海浮石, Pumice) for Hai Fen, and this substitution became standard in later usage. Notably, the original text recorded no specific dosages, which was characteristic of many Yuan Dynasty prescriptions that left dosing to the practitioner's discretion. The formula was originally prepared as honey pills with ginger juice, designed to be slowly dissolved in the mouth (噙化) rather than swallowed, allowing the herbs to coat the throat and act locally on the airways.

The Ming Dynasty physician Wu Kun (吴昆) provided the most famous commentary on this formula in his Yi Fang Kao (《医方考》), eloquently explaining its logic: the formula contains no blood-stopping herbs because "once the Fire is gone, the blood naturally stops on its own" (火去而血自止也). This principle became a model for treating bleeding disorders through addressing the root cause rather than the symptoms.