Xie Bai San

Drain the White Powder · 瀉白散

Also known as: Xie Fei San (泻肺散, Drain the Lung Powder)

A gentle classical formula originally designed for children to clear hidden heat from the Lungs. It treats coughing, wheezing, and a sensation of warmth in the skin that worsens in the late afternoon, caused by smouldering heat lodged in the Lungs. Its mild, sweet-natured herbs clear Lung heat without harming the body's reserves.

Origin Xiao Er Yao Zheng Zhi Jue (小儿药证直诀) by Qian Yi (钱乙), compiled by Yan Xiaozhong (阎孝忠) — Northern Sòng dynasty, 1119 CE
Composition 4 herbs
Sang Bai Pi
King
Sang Bai Pi
Di Gu Pi
Deputy
Di Gu Pi
Gan Cao
Assistant
Gan Cao
Jing Mi
Envoy
Jing Mi
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Xie Bai San is designed to correct these specific patterns.

Why Xie Bai San addresses this pattern

Xie Bai San specifically targets Lung heat of the 'hidden fire' (伏火) type, not acute blazing Lung heat. In this pattern, heat becomes lodged within the Lungs over time, disrupting the Lung's essential function of keeping Qi flowing smoothly downward. When Lung Qi rebels upward due to heat obstruction, coughing and wheezing result. Because the Lungs govern the skin and body hair, internal Lung heat steams outward to the surface, causing a distinctive warmth in the skin that is felt on light touch but fades on sustained pressure, distinguishing it from the intense heat of exterior febrile conditions. The heat worsens in the late afternoon (around 3-5 PM), which corresponds to the time when Lung-Metal Qi is naturally most active. Sang Bai Pi and Di Gu Pi together drain this hidden fire from both the Qi and Yin layers of the Lungs. Zhi Gan Cao and Jing Mi protect the Stomach and Spleen, ensuring the clearing action does not weaken the child's constitution.

A practitioner would look for one or more of these signs

Hypochondrial Pain That Is Worse On Coughing And Breathing

Persistent cough, often dry or with scant sputum

Wheezing

Wheezing or shortness of breath from upward-rebelling Lung Qi

Low Grade Fever

Skin feels warm to light touch but not deep pressure, worse in late afternoon

Flushed Face

Flushing on the right cheek, indicating Lung heat

Dry Mouth

Dry mouth with thirst as heat begins to consume Lung fluids

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Xie Bai San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Lung Heat

TCM Interpretation

In TCM, bronchitis with a heat pattern is understood as heat lodging in the Lungs and disrupting their core function of descending and distributing Qi and fluids. The Lungs are described as a 'delicate organ' that is easily disturbed by both external invasion and internal heat. When heat accumulates, it causes Lung Qi to rebel upward instead of descending, producing cough, wheezing, and a feeling of chest tightness. In children especially, this heat can smoulder quietly (伏火) rather than flaring dramatically, producing a warm skin sensation and afternoon worsening rather than high fever. The heat also begins to dry out Lung fluids over time, which is why the cough may be dry or produce only scanty, sticky sputum.

Why Xie Bai San Helps

Xie Bai San directly addresses this pattern by using Sang Bai Pi to clear Lung heat and redirect Lung Qi downward, relieving cough and wheezing at their source. Di Gu Pi reaches deeper to drain the hidden, smouldering fire that sustains the chronic inflammation. Because both herbs are mild and sweet-cold rather than harshly bitter-cold, they clear heat without further drying out the Lungs or damaging digestive function. Zhi Gan Cao and Jing Mi protect the Stomach and support the Spleen, which is especially important in children or patients with weak digestion. Modern research has confirmed anti-inflammatory activity in the formula's key components, aligning with its traditional use for inflammatory respiratory conditions.

Also commonly used for

Whooping Cough

Pertussis (whooping cough) with Lung heat pattern

Measles

Early-stage measles with Lung heat signs before rash fully erupts

Bronchiectasis

Bronchiectasis with chronic cough from residual Lung heat

Urticaria

Skin rashes or hives related to Lung heat steaming outward to the skin

Allergic Sinusitis

Nasal conditions where Lung heat drives congestion or inflammation

What This Formula Does

Every TCM formula has a specific set of actions — here's what Xie Bai San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Xie Bai San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Xie Bai San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Xie Bai San works at the root level.

Xie Bai San addresses a specific pattern: lurking Fire (伏火 fú huǒ) smoldering within the Lungs. This is not a raging, full-blown Heat condition, but rather a low-grade, persistent Heat that has settled deep inside the Lung system.

The Lungs are responsible for governing Qi and maintaining a natural downward, clearing flow. When Fire becomes lodged inside the Lungs, this descending function is disrupted. Qi rebels upward instead of descending, producing coughing and wheezing. Because the Lungs connect to the skin and body surface, this internal Heat seeps outward, causing the skin to feel warm to the touch. A distinctive diagnostic feature is that this steaming skin heat is worse in the late afternoon (around 3-5 PM, the time associated with the Lung system). Importantly, the warmth is superficial: it can be felt on light touch but fades when one presses deeply, distinguishing it from the burning Heat of a full Yang Ming fever. The tongue turns red with a yellow coating, and the pulse becomes thin and rapid, signs that the Heat is beginning to consume the body's Yin (cooling, moistening) fluids.

This type of lurking Fire is especially common in children, whose bodies are described in classical texts as having "delicate organs, easily affected by deficiency or excess, easily chilled or overheated" (脏腑柔弱,易虚易实,易寒易热). A child's Lung system is immature and vulnerable to Heat settling in without a dramatic exterior presentation. The formula's gentle, draining approach matches this pathology perfectly: it clears the smoldering Heat without being so cold and harsh that it damages the child's fragile constitution.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly sweet and mildly bitter. The sweet taste from Sang Bai Pi, Gan Cao, and Jing Mi nourishes and protects the Stomach, while the bitter quality from Di Gu Pi drains Heat downward from the Lungs.

Channels Entered

Ingredients

4 herbs

The herbs that make up Xie Bai San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Sang Bai Pi

Sang Bai Pi

White mulberry root bark

Dosage 9 - 15g
Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Lungs, Spleen
Preparation Stir-fried with honey (蜜炙)

Role in Xie Bai San

Sweet and cold, enters the Lung channel, directly clears and drains Lung heat, descends rebellious Lung Qi, and stops coughing and wheezing. As the principal herb it addresses the core pathomechanism of heat obstructing the Lung's descending function.
Deputy — Assists and enhances the King
Di Gu Pi

Di Gu Pi

Lycium root bark

Dosage 9 - 15g
Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Lungs, Liver, Kidneys

Role in Xie Bai San

Sweet, bland, and cold, enters the Lung and Kidney channels. Penetrates deeply into the Yin level to drain hidden fire (伏火) from the Lungs and clear deficiency heat. Complements the King herb by addressing the deeper, smouldering aspect of Lung heat that produces steaming sensations in the skin and afternoon worsening.
Assistant — Supports or moderates other herbs
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Xie Bai San

Sweet and neutral, nourishes the Spleen and Stomach to protect them from the cold nature of the other herbs. Supports the Spleen to 'nourish the mother of Metal' (培土生金), indirectly supporting Lung Qi while harmonising the formula.
Envoy — Directs the formula to its target
Jing Mi

Jing Mi

Non-glutinous rice

Dosage 6 - 10g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Lungs

Role in Xie Bai San

Sweet and neutral, protects the Stomach and harmonises the Middle Burner. Works alongside Zhi Gan Cao to ensure the cold, draining herbs do not injure the Spleen and Stomach, embodying the 'nourish Earth to generate Metal' strategy.

Why This Combination Works

How the herbs in Xie Bai San complement each other

Overall strategy

The formula targets hidden fire lodged in the Lungs (肺有伏火) that disrupts the Lung's normal descending function. Rather than using intensely bitter-cold herbs like Huang Qin or Huang Lian, which could damage a child's delicate constitution, it employs sweet, mildly cold bark herbs that gently drain Lung heat while protecting Yin and Stomach Qi.

King herbs

Sang Bai Pi (Mulberry Root Bark) is the sole King herb. Sweet and cold with a descending nature, it enters the Lung channel directly to clear heat and redirect Lung Qi downward. This addresses the core problem: heat forcing Lung Qi upward, causing coughing and wheezing. Its mild nature allows it to drain without injuring the Lungs, which TCM regards as a 'delicate organ' (娇脏) that cannot tolerate harshness.

Deputy herbs

Di Gu Pi (Lycium Root Bark) serves as Deputy. While Sang Bai Pi clears heat from the Qi level of the Lungs, Di Gu Pi penetrates deeper into the Yin level to draw out hidden, smouldering fire. This is crucial because the pattern involves not surface-level heat but fire lodged deep within the Lungs, which is why the skin feels warm to light touch but not to sustained pressure. Together, King and Deputy clear both the superficial and deep layers of Lung heat.

Assistant herbs

Zhi Gan Cao (honey-prepared Licorice) acts as a reinforcing Assistant. Its sweet flavour tonifies the Spleen, implementing the 'nourish Earth to generate Metal' (培土生金) principle: by strengthening the Spleen (Earth), the Lungs (Metal) are indirectly supported. It also moderates the cold properties of the two bark herbs, protecting the digestive system.

Envoy herbs

Jing Mi (rice) harmonises the Middle Burner and anchors the formula in the Stomach, ensuring that the draining action of the formula does not deplete the body's righteous Qi. Together with Zhi Gan Cao, it keeps the formula balanced between clearing and protecting.

Notable synergies

The Sang Bai Pi and Di Gu Pi pairing is the heart of the formula. Both are root barks, both are sweet and cold, but they work at different levels: Sang Bai Pi drains Lung Qi-level heat while Di Gu Pi clears deeper Yin-level hidden fire. Their combined effect is described classically as 'clearing with moisture, draining with nourishment' (清中有润,泻中有补). The Zhi Gan Cao and Jing Mi pairing forms a protective base that prevents the cold herbs from harming the Spleen and Stomach.

How to Prepare

Traditional preparation instructions for Xie Bai San

In the original text, the herbs are ground into a coarse powder (锉散). A small handful of rice (粳米) is added, along with approximately 300 mL of water. The mixture is decocted down to about 200 mL and taken before meals.

In modern practice, the herbs are simply prepared as a standard decoction (水煎服). All ingredients are combined with approximately 400-500 mL of water, brought to a boil, then simmered for 20-30 minutes. The decoction is strained and taken warm in two divided doses, ideally before meals.

Common Modifications

How practitioners adapt Xie Bai San for specific situations

Added
Huang Qin

9-12g, strongly clears Lung heat

Zhi Mu

9-12g, clears heat and nourishes Yin

When Lung heat is intense and the base formula's gentle approach is insufficient, Huang Qin and Zhi Mu add stronger heat-clearing power while Zhi Mu also protects Yin from heat damage.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Xie Bai San should not be used or requires extra caution

Avoid

Wind-Cold cough: This formula is cold in nature and designed for Heat patterns. Using it for cough caused by external Wind-Cold invasion (with chills, clear or white watery phlegm, absence of thirst) would worsen the condition by further cooling the Lungs.

Avoid

Lung deficiency cough or wheezing: If the cough arises from chronic Lung Qi or Lung Yin deficiency rather than from lurking Fire, this formula's draining action could further weaken the Lungs. Signs include a weak, breathy cough, shortness of breath on exertion, and a pale tongue.

Avoid

Damp-Phlegm obstruction cough: Coughing with copious white, sticky phlegm from Spleen deficiency generating Dampness requires a Phlegm-transforming approach, not Heat-clearing. This formula does not address Phlegm accumulation.

Caution

Spleen and Stomach deficiency with cold: The cool nature of Sang Bai Pi and Di Gu Pi may injure a weak digestive system. If there are signs of poor appetite, loose stools, or cold limbs, use with caution or modify by increasing the dose of Zhi Gan Cao and Jing Mi.

Caution

External Wind-Heat with strong exterior symptoms: If the patient has active fever, chills, sore throat, and a floating pulse indicating an unresolved exterior condition, this formula alone is insufficient because it only addresses internal lurking Heat, not exterior pathogens.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered low-risk, but caution is advised. Sang Bai Pi (mulberry root bark) has a mild diuretic action and Di Gu Pi (lycium root bark) is cold in nature. While neither herb is classically listed as a pregnancy-prohibited substance, the formula's overall cold and draining character could theoretically weaken Qi in a pregnant woman with an already fragile constitution. Pregnant women should consult a qualified practitioner before use. If Lung Heat symptoms are present during pregnancy, the formula may be used short-term under professional supervision with appropriate dose adjustments.

Breastfeeding

No classical prohibitions exist for use during breastfeeding. The herbs in this formula (Sang Bai Pi, Di Gu Pi, Zhi Gan Cao, Jing Mi) are generally mild and are not known to contain toxic or strongly bioactive compounds that would pose a significant transfer risk through breast milk. Glycyrrhizin from Gan Cao (licorice) is the compound of most theoretical concern, as it can affect fluid balance and potassium levels, but the small amount of honey-fried Gan Cao in this formula makes this risk minimal. Short-term use at standard doses is likely safe during breastfeeding, but professional supervision is recommended as with all herbal formulas during lactation.

Children

Xie Bai San was specifically designed for pediatric use by Qian Yi, China's foremost historical pediatric specialist. It is one of the most appropriate Heat-clearing formulas for children because its herbs are mild in nature and avoid the harsh, bitter coldness of substances like Huang Lian or Huang Qin, which can easily damage a child's delicate digestive system. Dosage should be adjusted by age and weight. A common guideline: infants under 1 year may take one-quarter of the adult dose; children aged 1-5 may take one-third to one-half; children aged 6-12 may take one-half to two-thirds of the adult dose. The original text specifies preparing it as a fine powder and decocting with rice (Jing Mi), which both moderates the formula and protects the Stomach. The formula is considered safe for short-term use in children when the pattern fits (cough, wheezing, skin warmth worse in the afternoon, red tongue with yellow coating). It should not be continued long-term, as prolonged use of cold-natured herbs may weaken a child's Spleen Qi. Discontinue or modify once the Heat has cleared.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Xie Bai San

Glycyrrhiza (Gan Cao / Licorice) interactions: The honey-fried licorice in this formula, though present in small amounts, contains glycyrrhizin, which can cause potassium depletion and sodium retention with prolonged use. This may interact with diuretics (especially thiazides and loop diuretics, increasing the risk of hypokalemia), cardiac glycosides such as digoxin (hypokalemia increases digoxin toxicity), and corticosteroids (additive potassium loss and fluid retention). Glycyrrhizin may also reduce the effectiveness of antihypertensive medications through its mineralocorticoid-like effects.

Sang Bai Pi (Mulberry Root Bark): Has a mild diuretic and hypoglycemic effect. Theoretically, it could have an additive effect with antidiabetic medications (increasing risk of hypoglycemia) or diuretic drugs. Patients on these medications should be monitored.

At standard short-term doses, clinically significant interactions are unlikely. However, patients taking any of the above medication classes should inform their prescribing physician and TCM practitioner.

Usage Guidance

Practical advice for getting the most out of Xie Bai San

Best time to take

Before meals (食前服), as originally specified in the classical text. Traditionally taken warm, twice daily.

Typical duration

Acute use: 3-7 days for active cough and wheezing episodes. Reassess if symptoms persist beyond one week.

Dietary advice

While taking this formula, avoid foods that generate Heat or Phlegm: greasy, fried, and heavily spiced foods; lamb, shrimp, and other warming meats; chocolate, coffee, and alcohol. Cold and raw foods should also be limited, as they can impair the Spleen's digestive function, which the formula relies on to support the Lungs (Earth generates Metal in Five-Phase theory). Favor light, easy-to-digest foods that moisten the Lungs and clear mild Heat: pears, white radish (daikon), lotus root, lily bulb (bai he), loquat, mung beans, and congee (rice porridge, which complements the Jing Mi already in the formula). Adequate hydration is important to help the body clear Heat and protect Yin fluids.

Xie Bai San originates from Xiao Er Yao Zheng Zhi Jue (小儿药证直诀) by Qian Yi (钱乙), compiled by Yan Xiaozhong (阎孝忠) Northern Sòng dynasty, 1119 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Xie Bai San and its clinical use

《医方考》 (Yī Fāng Kǎo, Investigations of Medical Formulas):
"肺火为患,喘满气急者,此方主之。"
"When Lung Fire causes illness with wheezing, fullness, and rapid breathing, this formula governs it."

《古方选注》 (Gǔ Fāng Xuǎn Zhù, Selected Annotations on Classical Formulas):
"桑皮、甘草,其气俱薄,不燥不刚,虽泻而不伤于娇脏。"
"The Qi of Sang Bai Pi and Gan Cao is thin and mild, neither drying nor harsh. Though they drain, they do not injure the delicate organ [the Lungs]."

《古方选注》:
"肺苦气上逆,急食苦以泄之,故复以地骨皮之苦,泄阴火,退虚热,而平肺气。使以粳米、甘草,缓桑、骨二皮于上,以清肺定喘。"
"The Lungs suffer from Qi counterflowing upward; one should quickly use something bitter to drain it. Thus Di Gu Pi's bitter nature is used to drain Yin-level Fire, retire deficiency Heat, and calm Lung Qi. Jing Mi and Gan Cao moderate the two bark herbs above, to clear the Lungs and settle wheezing."

Historical Context

How Xie Bai San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Xie Bai San was created by Qian Yi (钱乙, courtesy name Zhongyang 仲阳, c. 1032-1113), the most celebrated pediatric physician in Chinese medical history. Qian Yi dedicated over 40 years exclusively to treating children and is honored as the "Sage of Pediatrics" (儿科之圣) and "Ancestor of Pediatric Medicine" (幼科之鼻祖). His clinical teachings were compiled after his death by his student Yan Jizhong (阎季忠) into the landmark text Xiao Er Yao Zheng Zhi Jue (《小儿药证直诀》, Key to Therapeutic Patterns in Children's Medicine), completed in 1119 CE. This book is recognized as the earliest surviving systematic pediatric medical text in the world.

Xie Bai San is one of several organ-specific formulas Qian Yi devised based on his innovative Five-Organ pattern differentiation system for children. Alongside it sit Xie Huang San (draining Spleen Heat), Dao Chi San (guiding out Heart Heat), and Xie Qing Wan (draining Liver Fire), each targeting a specific organ system. This systematic, organ-based approach was groundbreaking. The formula's name, "Drain the White Powder," refers to white as the color associated with the Lungs in Five-Phase theory. In 2018, the Chinese government included Xie Bai San in its first official catalogue of 100 ancient classical prescriptions (古代经典名方目录) approved for modern development, affirming its enduring clinical significance.

Over the centuries, numerous variants emerged. Notable modifications include the addition of Huang Qin and Zhi Mu for more severe Lung Heat (《杂病源流犀烛》), and the Sang Dan Xie Bai San from the Qing Dynasty's Guang Wen Re Lun (《广温热论》), which added Sang Ye, Ju Hua, Dan Pi, and other herbs for treating residual Heat in warm-febrile diseases.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Xie Bai San

1

Network Pharmacology and In Vivo Study of Xie-Bai-San for Allergic Asthma (Preclinical, 2025)

Study published in Journal of Ethnopharmacology, 2025, ScienceDirect

This study used network pharmacology, molecular docking, and mouse experiments to investigate how Xie Bai San works against allergic asthma. Researchers identified 119 active compounds and 237 potential gene targets. In the animal model, XBS reduced inflammatory cells in lung fluid and lowered key inflammatory markers (IL-1β, TNF-α, IL-6). It also decreased goblet cell overgrowth in the airways. The mechanism was linked to IL-17 and TNF signaling pathways.

Link
2

Xiebai San Alleviates Acute Lung Injury via ERK/Stat3 Pathway Inhibition (Preclinical, 2024)

Published in European Journal of Pharmacology, 2024, ScienceDirect

This integrated pharmacology study used LPS-induced acute lung injury in mice to explore XBS mechanisms. Researchers identified primary chemical components via mass spectrometry and established potential drug targets through network pharmacology. The study found that XBS alleviates acute lung injury by inhibiting phosphorylation of the ERK/Stat3 signaling pathway and regulating multiple metabolic pathways, confirmed through transcriptomics and metabolomics.

Link
3

Self-Assembled Nanoparticles from Xie-Bai-San Decoction: Enhancing Oral Bioavailability (Pharmacokinetic, 2024)

Published in International Journal of Nanomedicine, 2024, Volume 19, Pages 3377-3394

This study isolated and characterized natural nanoparticles that spontaneously form when Xie Bai San is decocted. The nanoparticles (average size ~105 nm) contained most of the formula's active compounds and significantly enhanced the oral bioavailability of key components compared to the non-nanoparticle fraction, suggesting the traditional decoction method itself plays a role in optimizing drug delivery.

PubMed
4

Identification and Determination of Major Constituents in Xie-Bai-San (Phytochemical Analysis, 2024)

Published in World Journal of Traditional Chinese Medicine, 2024, Volume 10, Issue 3

This analytical chemistry study used advanced mass spectrometry and molecular networking to identify 91 chemical compounds in the Xie Bai San decoction, including stilbene glycosides, saponins, flavonoids, and alkaloids. It also established a quantification method for four key marker compounds: mulberroside A, kukoamine B, liquiritin, and glycyrrhizic acid, providing a quality control foundation for standardized production.

Link

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.