Bai He Gu Jin Tang

Lily Bulb Decoction to Preserve the Metal · 百合固金湯

Also known as: Lily Bulb Decoction to Consolidate the Lungs, Lily Bulb Decoction to Preserve the Metal

A classical formula for nourishing the Lungs and Kidneys when they have become too dry and hot internally. It is commonly used for chronic dry cough, sore throat, blood-tinged sputum, night sweats, and afternoon fevers caused by a deep depletion of the body's moistening fluids. The name means "Lily Bulb Decoction to Preserve the Metal," where "Metal" refers to the Lungs in TCM's Five Phase system.

Origin Writings for Posterity of [Zhou] Shen-Zhai (1573 AD) — Míng dynasty, c. 1573 CE
Composition 10 herbs
Bai He
King
Bai He
Shu Di Huang
King
Shu Di Huang
Shu Di Huang
King
Shu Di Huang
Mai Dong
Deputy
Mai Dong
Xuan Shen
Deputy
Xuan Shen
Dang Gui
Assistant
Dang Gui
Bai Shao
Assistant
Bai Shao
Chuan Bei Mu
Assistant
Chuan Bei Mu
+2
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Bai He Gu Jin Tang is designed to correct these specific patterns.

Why Bai He Gu Jin Tang addresses this pattern

This is the core pattern Bai He Gu Jin Tang was designed for. When Kidney Yin becomes depleted, it can no longer nourish its 'mother' organ, the Lung (in Five Phase theory, Metal generates Water, so the Lung is the mother of the Kidney). With both organs running dry, internal Heat flares upward, scorching the Lung's delicate tissues and airways. This produces a dry, hacking cough, parched and sore throat, and potentially blood-streaked sputum where the deficiency Heat damages the fine vessels of the Lung.

The formula addresses both root and branch simultaneously. The three chief herbs, Bai He (lily bulb), Sheng Di Huang (raw Rehmannia), and Shu Di Huang (prepared Rehmannia), replenish Yin in both the Lung and the Kidney. Bai He moistens the Lung directly, while the two Rehmannias together nourish Kidney Yin and cool the Blood. Sheng Di Huang adds the important action of cooling Blood and stopping bleeding. Mai Dong (Ophiopogon) reinforces Lung moisture alongside Bai He, while Xuan Shen (Scrophularia) assists the Rehmannias in enriching Kidney Yin and quelling deficiency Fire. Bei Mu (Fritillaria) and Jie Geng (Platycodon) address the branch symptoms by resolving Phlegm and opening the throat. Dang Gui and Bai Shao nourish Blood to support Yin regeneration and soften the Liver to prevent it from further attacking the weakened Lung. Gan Cao harmonises the formula and, paired with Jie Geng, specifically soothes the throat.

A practitioner would look for one or more of these signs

Dry Cough

Persistent dry cough, or cough with scant, sticky phlegm that is difficult to expectorate

Sore Throat

Dry, burning sore throat that worsens in the afternoon or evening

Hemoptysis

Blood-streaked sputum or frank coughing of blood from deficiency Heat damaging Lung vessels

Night Sweats

Night sweats from Yin deficiency with internal Heat

Afternoon Fever

Low-grade tidal fever, typically in the afternoon, from Yin deficiency Heat

Hot Palms And Soles

Five-palm Heat: warmth in palms, soles, and chest from deficiency Fire

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Bai He Gu Jin Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, chronic bronchitis that presents with a dry, persistent cough, little or sticky sputum, dry throat, and signs of Heat (such as afternoon warmth, night sweats, or a red tongue with little coating) is understood as the Lung failing to moisten and descend properly. Prolonged illness, repeated infections, smoking, or dry environments gradually consume Lung Yin, the body's lubricating and cooling resources for the airways. Over time, this Lung damage draws on the Kidney, which is the root source of all Yin in the body. When both Lung and Kidney Yin are depleted, deficiency Heat rises unchecked, further drying the airways and perpetuating the cough.

This is fundamentally different from the phlegm-damp type of bronchitis (which produces copious white or clear sputum). The Yin-deficient presentation is marked by dryness and Heat rather than dampness and cold.

Why Bai He Gu Jin Tang Helps

Bai He Gu Jin Tang addresses chronic bronchitis of the Yin-deficient type by restoring moisture to the Lung while simultaneously replenishing the deeper Yin reserves of the Kidney. Bai He and Mai Dong directly moisten the Lung tissues and calm cough. Bei Mu transforms any thick, sticky Phlegm that has formed from the dryness, while Jie Geng opens the airways and guides the other herbs to the chest. The two Rehmannias (Sheng Di Huang and Shu Di Huang) nourish Kidney Yin at the root level, ensuring the Lung has a deep reservoir of moisture to draw from. Xuan Shen reinforces this Yin-nourishing and Heat-clearing action. Dang Gui and Bai Shao nourish the Blood, which is essential because Blood and Yin share a common source: replenishing one supports the other. Modern pharmacological research has confirmed the formula's anti-inflammatory, antitussive, and expectorant properties, supporting its traditional use for chronic cough conditions.

Also commonly used for

Bronchiectasis

When the main complaint is hemoptysis or blood-streaked sputum from Yin deficiency Heat

Asthma

Dry-type asthma with Yin deficiency, dry cough, and little sputum

Spontaneous Pneumothorax

Particularly in cases with underlying tuberculosis and Lung-Kidney Yin deficiency

Chronic Coughing

Persistent post-infectious or idiopathic cough with dryness and Yin deficiency signs

Pneumonia

Late-stage or recovery-phase pneumonia where Heat has damaged Lung Yin

Lung Cancer

As integrative supportive therapy, especially to reduce side effects of chemo/radiotherapy in Yin-deficient patients

Epistaxis

Nosebleeds from Yin deficiency with deficiency Heat rising to damage nasal vessels

What This Formula Does

Every TCM formula has a specific set of actions — here's what Bai He Gu Jin Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Bai He Gu Jin Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Bai He Gu Jin Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Bai He Gu Jin Tang works at the root level.

This formula addresses a pattern where both the Lungs and Kidneys have become depleted of Yin (the body's cooling, moistening substances). In TCM theory, the Lungs and Kidneys share a mother-child relationship through the Metal-Water (金水) cycle of the Five Phases: the Lungs (Metal) are the "mother" that generates Kidney (Water). When the Lungs are weakened, the Kidneys eventually suffer too, and when Kidney Yin is depleted, it can no longer nourish the Lungs from below. This creates a vicious cycle of mutual depletion.

Without sufficient Yin to anchor and cool the body, deficiency Heat (虚火, "empty fire") flares upward. This rising Heat dries out the throat, causing burning soreness and hoarseness. It scorches the delicate Lung vessels, which can lead to blood appearing in the phlegm. The Lungs lose their ability to descend and purify Qi, resulting in coughing and mild wheezing. Because body fluids are depleted, any phlegm that forms tends to be scanty and sticky rather than copious. The general depletion of Yin also produces systemic signs like afternoon tidal fever, night sweats, flushed cheeks, and a sensation of heat in the palms and soles.

The tongue and pulse reflect this underlying dryness and Heat: the tongue is red with little or no coating (because fluids are insufficient to produce a normal coating), and the pulse is thin and rapid (thin from depleted blood and fluids, rapid from deficiency Heat).

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly sweet and bitter with undertones of salty flavor. Sweet to nourish Yin and generate fluids, bitter to gently clear deficiency Heat, salty to soften and direct action downward to the Kidneys.

Target Organs

Channels Entered

Lung Kidney Heart

Ingredients

10 herbs

The herbs that make up Bai He Gu Jin Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Bai He

Bai He

Lily bulb

Dosage 9 - 15g
Temperature Slightly Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Heart, Lungs

Role in Bai He Gu Jin Tang

Sweet, slightly bitter, and slightly cold, Bai He is the formula's namesake and lead herb for moistening the Lung, stopping cough, and clearing deficiency Heat from the upper body. It generates fluids and protects the Lung directly.
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 9 - 15g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Bai He Gu Jin Tang

Cold and sweet-bitter, Sheng Di Huang nourishes Yin, clears Heat, and cools the Blood to stop bleeding. Working alongside Shu Di Huang, it addresses both the Kidney Yin deficiency and the bleeding caused by deficiency Fire scorching the Lung vessels.
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 9 - 15g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Bai He Gu Jin Tang

Warm and sweet, Shu Di Huang is the primary herb for deeply nourishing Kidney Yin and replenishing Blood. Paired with Sheng Di Huang, it fulfills the strategy of enriching the Kidneys and strengthening the Water source so the Kidneys can again nourish the Lungs (Metal).
Deputies — Assists and enhances the King
Mai Dong

Mai Dong

Ophiopogon root

Dosage 6 - 12g
Temperature Slightly Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, Stomach

Role in Bai He Gu Jin Tang

Sweet and cold, Mai Dong assists Bai He in nourishing Lung Yin, clearing Heat, and moistening dryness. It generates fluids and soothes the throat.
Xuan Shen

Xuan Shen

Ningpo figwort root

Dosage 3 - 6g
Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Lungs, Stomach, Kidneys

Role in Bai He Gu Jin Tang

Salty and cold, Xuan Shen assists the two Rehmannia roots in enriching Yin and strengthening the Water element to clear deficiency Fire. It also benefits the throat, helping to relieve dryness and soreness.
Assistants — Supports or moderates other herbs
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 6 - 9g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Bai He Gu Jin Tang

Warm, sweet, and acrid, Dang Gui nourishes and invigorates the Blood. Chronic coughing with blood-streaked phlegm depletes the Blood over time. Dang Gui replenishes the Blood and, classically noted for treating cough with rebellious Qi, it complements the Yin-nourishing herbs from a different angle.
Bai Shao

Bai Shao

White peony root

Dosage 3 - 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen

Role in Bai He Gu Jin Tang

Bitter, sour, and slightly cold, Bai Shao nourishes the Blood, restrains Yin, and softens the Liver. When Lung Metal is weakened it cannot restrain Liver Wood, and unchecked Liver Fire further attacks the Lungs. Bai Shao calms the Liver and preserves Yin fluids.
Chuan Bei Mu

Chuan Bei Mu

Sichuan fritillary bulb

Dosage 3 - 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Lungs, Heart

Role in Bai He Gu Jin Tang

Bitter, sweet, and slightly cold, Chuan Bei Mu clears Heat from the Lungs, moistens dryness, and transforms phlegm to stop coughing. It addresses the secondary symptom of phlegm that accompanies the primary Yin deficiency.
Envoys — Directs the formula to its target
Jie Geng

Jie Geng

Platycodon root

Dosage 3 - 6g
Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs

Role in Bai He Gu Jin Tang

Bitter, acrid, and neutral, Jie Geng opens and diffuses Lung Qi, clears the throat, and disperses phlegm. Critically, it directs the other herbs upward to the Lungs, serving as the formula's guide herb. Paired with Gan Cao, it forms a classic combination for soothing sore throats.
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Preparation Use raw (Sheng Gan Cao 生甘草), not honey-prepared

Role in Bai He Gu Jin Tang

Sweet and neutral (raw form used here), Gan Cao clears Heat, soothes the throat in combination with Jie Geng, and harmonizes all the herbs in the formula. The raw form (Sheng Gan Cao) is preferred for its Heat-clearing properties.

Why This Combination Works

How the herbs in Bai He Gu Jin Tang complement each other

Overall strategy

This formula addresses a condition where both the Lung and Kidney Yin have become depleted, allowing deficiency Fire to flare upward and damage the Lungs. The prescription strategy simultaneously nourishes Kidney Yin (the root) and moistens the Lungs (the branch), a classical approach called "Metal and Water nourished together" (金水并补). By replenishing the Yin source in the Kidneys and directly soothing the Lungs, the deficiency Fire is quenched at its origin rather than forcibly suppressed with bitter-cold herbs.

King herbs

Bai He (Lily Bulb), Sheng Di Huang (raw Rehmannia), and Shu Di Huang (prepared Rehmannia) form the three-herb core. Bai He directly moistens the Lungs, stops coughing, and gently clears deficiency Heat from the upper body. The two Rehmannia roots work together to replenish Kidney Yin and nourish the Blood: Sheng Di Huang is cold and excels at cooling the Blood and stopping bleeding (addressing blood-streaked phlegm), while Shu Di Huang is warm and deeply nourishes Kidney Yin and essence. Together these three herbs address both the Lung and the Kidney aspects of the condition.

Deputy herbs

Mai Dong (Ophiopogon) reinforces Bai He's Lung-moistening and Heat-clearing action, further generating fluids and soothing dryness. Xuan Shen (Scrophularia) reinforces the Rehmannia roots' Kidney-nourishing function, enriching Yin to control deficiency Fire, while also benefiting the throat to relieve soreness and dryness.

Assistant herbs

Dang Gui and Bai Shao nourish and harmonize the Blood (reinforcing assistants). Chronic Yin deficiency with bleeding gradually depletes the Blood, and these two herbs replenish it. Bai Shao also calms the Liver, which is important because weakened Lung Metal cannot restrain Liver Wood, and unchecked Liver Fire would further attack the Lungs. Chuan Bei Mu serves as a different type of reinforcing assistant: it moistens the Lungs, clears Heat, and transforms phlegm, directly addressing the secondary symptom of cough with phlegm.

Envoy herbs

Jie Geng opens and diffuses Lung Qi and guides the other herbs upward to reach the Lungs, making it an essential directional envoy. It also disperses phlegm and clears the throat. Gan Cao (raw form) clears residual Heat, soothes the throat in its classic pairing with Jie Geng, and harmonizes all the ingredients. The use of raw rather than honey-prepared Gan Cao preserves its Heat-clearing capacity.

Notable synergies

The Sheng Di Huang and Shu Di Huang pairing is central: raw Rehmannia cools and stops bleeding while prepared Rehmannia deeply nourishes Yin, together covering both the acute symptom (bleeding) and the root cause (Yin depletion). The Jie Geng and Gan Cao pair (a small formula in its own right) specifically targets throat soreness and pain. The overall design uses exclusively sweet and cool herbs rather than harsh bitter-cold ingredients, reflecting the classical principle of nurturing the body's regenerative capacity (甘寒培元清本) rather than risking further damage to weakened Yin.

How to Prepare

Traditional preparation instructions for Bai He Gu Jin Tang

Prepare as a standard water decoction (水煎服). Place all herbs in a ceramic or clay pot with approximately 600–800 mL of water. Bring to a boil, then simmer on low heat for 25–30 minutes. Strain the liquid and set aside. A second decoction can be prepared by adding 400–500 mL of fresh water and simmering for 15–20 minutes. Combine the two decoctions and divide into two portions, taken warm in the morning and evening, ideally between meals.

The original text in the Shen Zhai Yi Shu (慎斋遗书) does not specify detailed preparation instructions beyond water decoction. Modern clinical practice typically follows the standard decoction method described above.

Common Modifications

How practitioners adapt Bai He Gu Jin Tang for specific situations

Added
Bai Ji

Bai Ji 9–15g, astringes the Lung and stops bleeding

Bai Mao Gen

Bai Mao Gen 15–30g, cools the Blood and stops bleeding

Xian He Cao

Xian He Cao 9–15g, astringes to stop bleeding

Removed
Jie Geng

Remove to avoid its upward-lifting action, which may worsen bleeding

When hemoptysis is prominent, the ascending nature of Jie Geng may aggravate bleeding by directing Qi upward. Replacing it with hemostatic herbs directly addresses the damaged Lung vessels while preserving the formula's Yin-nourishing base.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Bai He Gu Jin Tang should not be used or requires extra caution

Avoid

External pathogen cough (wind-cold or wind-heat invasion). This formula is purely nourishing and does not expel pathogens. Using it during an active external invasion can trap the pathogen inside and worsen the condition.

Avoid

Phlegm-Dampness congestion (copious, white, sticky sputum). The formula's rich, moistening herbs will generate more Dampness and aggravate phlegm accumulation rather than resolve it.

Caution

Spleen and Stomach deficiency cold with loose stools. Many herbs in this formula are sweet, cold, and cloying (Sheng Di Huang, Shu Di Huang, Mai Dong, Xuan Shen, Bai He), which can further impair weak digestion and worsen diarrhea.

Avoid

Yang deficiency cough with internal cold or fluid retention. The formula's Yin-nourishing, cooling nature would compound existing Yang deficiency and could worsen fluid accumulation.

Avoid

Concurrent use with Wu Tou (Aconite root) preparations. The formula contains Bei Mu (Fritillaria), which is classically contraindicated with Wu Tou according to the traditional "Eighteen Incompatible Medicinals" (十八反).

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe when appropriately prescribed, but should be used with caution during pregnancy and only under professional supervision. Sheng Di Huang (raw Rehmannia) is cold in nature and Dang Gui (Angelica sinensis) mildly moves Blood, which warrant care during pregnancy. Neither herb is strongly abortifacient at standard doses, but the overall cold, Yin-nourishing character of the formula could theoretically affect digestive function during pregnancy. Pregnant individuals should only use this formula when clearly indicated for Lung-Kidney Yin deficiency and under the guidance of a qualified practitioner who can adjust the composition as needed.

Breastfeeding

No specific contraindication during breastfeeding has been established. The formula consists of gentle, nourishing herbs without known toxic components that would pose a risk through breast milk. However, its cold, Yin-enriching nature may theoretically affect the nursing parent's digestive function if the Spleen is already weak, which could indirectly impact milk production. Sheng Di Huang and Xuan Shen are cold herbs that should be used with awareness. Practitioners typically advise using the formula only when the presenting pattern clearly calls for it, and monitoring the infant for any changes in stool consistency. Professional guidance is recommended.

Children

Bai He Gu Jin Tang can be used in children when the pattern of Lung-Kidney Yin deficiency is clearly present, but with significant dosage reduction. The general guideline is to reduce the adult dose proportionally based on age and body weight: roughly one-quarter to one-third of the adult dose for children aged 3 to 6, and one-half for children aged 7 to 14. Because the formula contains rich, cloying herbs (particularly Shu Di Huang), it may be harder for children with immature digestive systems to tolerate. Practitioners often add small amounts of digestive-supporting herbs such as Chen Pi (dried tangerine peel) or reduce the Shu Di Huang dose when prescribing for children. Not recommended for infants under age 2 without specialist guidance.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Bai He Gu Jin Tang

Gan Cao (Licorice root) in this formula contains glycyrrhizin, which can cause potassium loss and sodium/fluid retention with prolonged use. This may interact with digoxin (increased toxicity risk due to hypokalemia), diuretics (compounded potassium loss, especially with thiazides and loop diuretics), corticosteroids (additive mineralocorticoid effects), and antihypertensive medications (reduced efficacy due to fluid retention).

Dang Gui (Angelica sinensis) has mild anticoagulant properties and may potentiate the effects of warfarin and other anticoagulants or antiplatelet drugs, increasing bleeding risk. Patients on blood thinners should be monitored.

Sheng Di Huang and Shu Di Huang (Rehmannia) may have mild hypoglycemic effects and could theoretically enhance the action of antidiabetic medications, warranting blood sugar monitoring in diabetic patients.

Xuan Shen (Scrophularia) has cardiac glycoside-like compounds and should be used with caution alongside cardiac glycosides (digoxin) due to potential additive effects.

Usage Guidance

Practical advice for getting the most out of Bai He Gu Jin Tang

Best time to take

Twice daily, 30 to 60 minutes after meals, to minimize any potential digestive discomfort from the rich, Yin-nourishing herbs.

Typical duration

Typically prescribed for 2 to 8 weeks, with reassessment by a practitioner at regular intervals depending on symptom improvement.

Dietary advice

Avoid spicy, hot, and fried foods (chili peppers, strong ginger, deep-fried items, alcohol, and coffee), which can generate Heat and consume Yin, directly opposing the formula's therapeutic intent. Smoking and tobacco should be strictly avoided. Favor moistening, Yin-nourishing foods such as pears, white fungus (Yin Er), lily bulb porridge, honey, sesame seeds, duck, tofu, and lightly cooked vegetables. Adequate hydration is important. Avoid cold, raw foods and iced drinks if digestion is already weak, since the formula itself is cooling and cloying. Rich, greasy, or heavily sweetened foods should also be minimized as they generate Dampness and Phlegm, which would counteract the formula's effect.

Bai He Gu Jin Tang originates from Writings for Posterity of [Zhou] Shen-Zhai (1573 AD) Míng dynasty, c. 1573 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Bai He Gu Jin Tang and its clinical use

《周慎斋遗书》(Zhou Shenzhai's Posthumous Writings) — Original Source Text

"手太阴肺病,有因悲哀伤肺,患背心、前胸肺募间热,咳嗽咽痛,咯血,恶寒,手大拇指循白肉际间上肩背,至胸前如火烙,宜百合固金汤。"

Translation: "For diseases of the Hand Taiyin Lung channel, when grief and sorrow injure the Lungs, the patient experiences heat between the upper back, the front of the chest, and the Lung alarm point region, with cough, sore throat, coughing blood, aversion to cold, and burning sensation along the thumb's lateral border up the shoulder and back to the front of the chest, as if seared by fire — use Bai He Gu Jin Tang."

《医方集解》(Collected Explanations of Medical Formulas) — Wang Ang (Qing Dynasty)

"此手太阴足少阴药也。金不生水,火炎水干,故以二地助肾滋水退热为君。百合保肺安神,麦冬清热润燥,元参助二地以生水,贝母散肺郁而除痰,归、芍养血兼以平肝,甘、桔清金,成功上部,皆以甘寒培元清本,不欲以苦寒伤生发之气也。"

Translation: "This is a formula for the Hand Taiyin [Lung] and Foot Shaoyin [Kidney] channels. When Metal fails to generate Water, and Fire blazes while Water dries up, the two Rehmanniae serve as sovereigns to assist the Kidneys, enrich Water, and clear Heat. Bai He protects the Lungs and calms the spirit; Mai Dong clears Heat and moistens dryness; Xuan Shen assists the two Rehmanniae in generating Water; Bei Mu disperses Lung stagnation and eliminates phlegm; Dang Gui and Bai Shao nourish Blood while also calming the Liver; Gan Cao and Jie Geng benefit the Metal [Lung] and direct action to the upper body. All use sweet and cool medicinals to cultivate the source and clear the root, without wishing to use bitter cold that would damage the generative Qi."

《医方论》(Discussion of Medical Formulas) — Fei Boxiong (Qing Dynasty)

"此方金水相生,又兼养血,治肺伤咽痛失血者最宜。"

Translation: "This formula uses the Metal-Water generating relationship and also nourishes the Blood. It is most suitable for treating Lung injury with sore throat and blood loss."

Historical Context

How Bai He Gu Jin Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Bai He Gu Jin Tang was first recorded in the Zhou Shenzhai Yi Shu (《周慎斋遗书》, "Zhou Shenzhai's Posthumous Writings"), attributed to the Ming Dynasty physician Zhou Zhigan (周之干, also known as Zhou Shenzhai). The text was published around 1573. The formula's theoretical roots trace back much earlier to Zhang Zhongjing's Jin Gui Yao Lue, which included Bai He Di Huang Tang (Lily Bulb and Rehmannia Decoction) for Lung and emotional disorders. Zhou Shenzhai built upon this foundation, expanding the formula into a comprehensive Yin-nourishing prescription for Lung-Kidney deficiency.

The formula became widely known through its inclusion in Wang Ang's (汪昂) influential Yi Fang Ji Jie (《医方集解》, 1682), where Wang attributed a version to Zhao Jian (赵蕺庵). Wang Ang's detailed commentary, classifying it as a "Hand Taiyin, Foot Shaoyin formula," helped establish its theoretical framework. Later, the Qing Dynasty physician Fei Boxiong (费伯雄) commented on it in his Yi Fang Lun (《医方论》), praising the formula's elegant use of the Metal-Water generating (金水相生) relationship.

The formula name itself is rich with meaning: "Bai He" (百合, Lily Bulb) is the representative herb; "Gu Jin" (固金, "securing Metal") refers to strengthening the Lungs (which correspond to Metal in Five Phase theory); and "Tang" (汤) means decoction. The name thus evokes the idea of a formula "as secure as a fortress of gold" (固若金汤) for protecting the Lungs. Over centuries, Bai He Gu Jin Tang has remained one of the most frequently used formulas for Lung-Kidney Yin deficiency and is now available as a modern patent medicine (Bai He Gu Jin Wan/Pian) throughout China.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Bai He Gu Jin Tang

1

Systematic review and meta-analysis: Baihe Gujin Decoction as adjunct to anti-tuberculosis chemotherapy for pulmonary tuberculosis (2025)

Zhao Y, Han Y, Liu J, Niu H, Wang P, Li Y, Liang J, Gong W. Frontiers in Pharmacology, 2025, 16:1538692.

A meta-analysis of 32 randomized controlled trials found that adding Bai He Gu Jin Tang to standard anti-tuberculosis drugs significantly improved clinical efficacy rates, lesion absorption, sputum conversion, and cavity closure compared to anti-TB drugs alone. The combination group also showed better immune function (higher CD4+ T cell levels) and fewer adverse reactions including liver damage and gastrointestinal side effects.

Link
2

Randomized controlled trial: Baihe Gujin Decoction combined with anti-tuberculosis therapy for pulmonary tuberculosis with Yin-deficiency syndrome (2020)

Ge HB, Zhu J. Journal of International Medical Research, 2020, 48(1):0300060519875535.

An RCT examining Bai He Gu Jin Tang as adjunctive therapy for pulmonary tuberculosis patients presenting with the Yin-deficiency and Fire-hyperactivity pattern. The study found that the combined treatment effectively alleviated TB symptoms, enhanced host immune function, and provided renal protection compared to standard anti-tuberculosis therapy alone.

Link
3

Network pharmacology and molecular docking study: Mechanism of Bai He Gu Jin Tang against non-small cell lung cancer (2022)

Xie RF, Song ZY, Xu-shao LY, Huang JG, Zhao T, Yang Z. Medicine (Baltimore), 2022, 101(52):e32555.

A network pharmacology study identified 147 active compounds and 228 potential targets through which this formula may act against non-small cell lung cancer. Key pathways identified included PI3K-Akt, MAPK, and cancer-related signaling pathways. Molecular docking confirmed strong binding between key compounds (luteolin, quercetin, beta-sitosterol) and hub targets. This is a computational study and does not constitute clinical evidence.

Link
4

Preclinical study: Bai-He-Gu-Jin-Tang suppresses lung cancer via AKT/GSK3β/β-catenin and induces autophagy via AMPK/mTORC1/ULK1 (2021)

Wu Q, Li D, Sun T, Liu J, Ou H, Zheng L, Hou X, Li W, Fan F. Journal of Cancer, 2021, 12(21):6576-6587.

A laboratory study using lung cancer cell lines and mouse models found that Bai He Gu Jin Tang inhibited tumor cell proliferation by promoting apoptosis through the AKT/GSK3β/β-catenin pathway and inducing autophagy through the AMPK/mTORC1/ULK1 pathway. These are preclinical findings only, not yet confirmed in human clinical trials.

Link

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.