Shi Jun Zi Wan

Quisqualis Pill · 使君子丸

A gentle classical pill formula designed primarily for children with intestinal parasites (especially roundworms) combined with poor digestion. It expels parasites while supporting the Spleen and Stomach, helping restore appetite, relieve abdominal bloating and pain, and reverse the progressive weight loss and weakness that result from parasitic infestation and nutritional decline.

Origin Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方), Shaoxing supplementary additions section (绍兴续添方) — Song dynasty (宋代), circa 1148 CE (Shaoxing period additions)
Composition 4 herbs
Shi Jun Zi
King
Shi Jun Zi
Hou Po
Deputy
Hou Po
Chen Pi
Assistant
Chen Pi
Chuan Xiong
Assistant
Chuan Xiong
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Shi Jun Zi Wan is designed to correct these specific patterns.

Why Shi Jun Zi Wan addresses this pattern

This formula directly treats intestinal parasitic infestation (虫积) in children. Shi Jun Zi is one of the most important antiparasitic herbs in the Chinese materia medica, with a long history of use against roundworms (Ascaris) and pinworms. Modern pharmacological research confirms that quisqualic acid, the active compound in Shi Jun Zi, paralyzes and kills intestinal parasites. The supporting herbs Hou Po and Chen Pi move Qi and relieve the abdominal distension and pain caused by parasites, while helping to expel the dead worms through normal bowel movements.

A practitioner would look for one or more of these signs

Abdominal Pain

Intermittent colicky pain around the navel, worse on empty stomach

Loss Of Appetite

Refusal to eat or picky eating habits

Abdominal Distention

Bloated abdomen, especially after eating

Emaciation

Progressive weight loss and muscle wasting despite eating

Nausea

Nausea or vomiting of clear fluid, sometimes with visible worms

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Shi Jun Zi Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, roundworm infestation (蛔虫病) is understood as a condition where parasites take up residence in the intestines due to an environment of internal Dampness and Spleen weakness. Children are particularly vulnerable because their Spleen and Stomach systems are still developing and easily disrupted by irregular diet or contaminated food. The parasites consume the child's nourishment and produce toxins that further weaken the Spleen, creating a vicious cycle of declining health. The key organ systems involved are the Spleen and Stomach, with Dampness accumulation and Qi stagnation as the primary pathogenic factors.

Why Shi Jun Zi Wan Helps

Shi Jun Zi Wan is specifically designed for this condition. The King herb, Shi Jun Zi, has been recognized for centuries as the premier child-safe antiparasitic herb. Unlike harsher alternatives, it is sweet and gentle, making it suitable for young patients with already weakened digestion. Hou Po and Chen Pi address the abdominal bloating and Qi stagnation that accompany the infestation, while Chuan Xiong helps move Blood to counter the stagnation from chronic malnutrition. The honey pill form makes the medicine palatable for children and provides mild nourishment to the weakened digestive system.

Also commonly used for

Enterobiasis

Pinworm infection in children

Abdominal Pain

Parasitic abdominal pain in children

Loss Of Appetite

Poor appetite in children due to parasites or Spleen weakness

Indigestion

Childhood dyspepsia with abdominal distension

What This Formula Does

Every TCM formula has a specific set of actions — here's what Shi Jun Zi Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Shi Jun Zi Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Shi Jun Zi Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Shi Jun Zi Wan works at the root level.

This formula addresses a condition commonly seen in children where intestinal parasites (particularly roundworms) combine with Spleen and Stomach weakness to produce a progressive decline in health known as "five gan" (五疳). The pathomechanism unfolds in several connected stages.

When a child's diet is irregular or contaminated, intestinal parasites take hold. The parasites themselves damage the Spleen and Stomach's ability to transform and transport food. As the Spleen weakens, Dampness accumulates internally, and Qi movement becomes sluggish. This creates abdominal bloating, intermittent abdominal pain (especially around the navel), and poor appetite. Since the Spleen can no longer properly extract nourishment from food, the child gradually becomes emaciated, with a sallow complexion and dry, listless hair.

The combination of parasitic infestation, Qi stagnation, and Spleen deficiency forms a self-reinforcing cycle: parasites weaken the Spleen, the weak Spleen fails to move Qi and fluids properly, and the resulting stagnation and Dampness create an environment where parasites thrive. This formula breaks the cycle by simultaneously expelling the parasites and restoring digestive function through moving Qi and strengthening the Spleen.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly sweet and slightly acrid, with mild aromatic and bitter undertones from the Qi-moving herbs. Sweet to benefit the Spleen and kill parasites gently, aromatic to move stagnant Qi and relieve abdominal distension.

Ingredients

4 herbs

The herbs that make up Shi Jun Zi Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Shi Jun Zi

Shi Jun Zi

Rangoon creeper fruit

Dosage 9 - 15g
Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach
Preparation Kernels soaked and black skin removed (仁浸,去黑皮)

Role in Shi Jun Zi Wan

The primary herb in this formula, Shi Jun Zi is sweet, warm, and enters the Spleen and Stomach channels. It is the principal anthelmintic (parasite-expelling) agent, effective at killing roundworms and other intestinal parasites. It also strengthens the Spleen and helps resolve childhood nutritional impairment (gan accumulation). Its large dosage relative to the other herbs confirms its King role.
Deputy — Assists and enhances the King
Hou Po

Hou Po

Magnolia bark

Dosage 3 - 6g
Temperature Warm
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs, Large Intestine
Preparation Bark removed, prepared with ginger juice (去皮,姜汁炙)

Role in Shi Jun Zi Wan

Hou Po is bitter, acrid, and warm. It dries Dampness, moves Qi, and resolves abdominal distension and fullness. In this formula it supports the King herb by addressing the bloating and Qi stagnation that accompany Spleen weakness and parasitic infestation in children.
Assistants — Supports or moderates other herbs
Chen Pi

Chen Pi

Tangerine peel

Dosage 3 - 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Spleen
Preparation White pith removed (去白)

Role in Shi Jun Zi Wan

Chen Pi regulates Qi, strengthens the Spleen, and dries Dampness. It works alongside Hou Po to relieve abdominal distension and improve digestive function, helping restore the child's appetite and ability to absorb nourishment.
Chuan Xiong

Chuan Xiong

Sichuan lovage rhizome

Dosage 3 - 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium

Role in Shi Jun Zi Wan

Chuan Xiong activates Blood circulation and moves Qi. In this formula it addresses the Blood stasis component that develops when prolonged Spleen weakness and parasitic infestation lead to poor nourishment and stagnation. It also helps distribute the formula's effects throughout the body.

Why This Combination Works

How the herbs in Shi Jun Zi Wan complement each other

Overall strategy

The formula addresses the dual problem of parasitic infestation and Spleen-Stomach weakness by combining a potent antiparasitic herb with Qi-moving and Spleen-supporting herbs. The goal is to eliminate the parasites while restoring the digestive system's ability to nourish the child.

King herbs

Shi Jun Zi (Quisqualis seed) is the undisputed King, used at a dosage vastly exceeding the other ingredients (1 liang versus 1 fen each in the original). It is sweet, warm, and fragrant, making it gentle enough for children while being highly effective at killing roundworms and other intestinal parasites. Unlike most antiparasitic herbs which are bitter or harsh, Shi Jun Zi also tonifies the Spleen, making it uniquely suited for treating the combined pattern of parasites with Spleen weakness.

Deputy herbs

Hou Po (Magnolia bark) serves as Deputy, using its bitter warmth to dry Dampness, move Qi downward, and relieve the abdominal distension and fullness that characterize this condition. It directly supports the King by addressing the Qi stagnation and Dampness that accompany parasitic infestation.

Assistant herbs

Chen Pi (tangerine peel) is a reinforcing Assistant that complements Hou Po's Qi-moving action with its gentle ability to regulate the Middle Burner, dry Dampness, and restore appetite. Chuan Xiong (Sichuan lovage root) serves as an Assistant that activates Blood circulation. In prolonged gan conditions, Blood stasis develops alongside Qi stagnation, and Chuan Xiong ensures that stagnant Blood is also addressed, helping distribute nourishment throughout the emaciated child's body.

Notable synergies

The pairing of Hou Po and Chen Pi creates a powerful Qi-moving duo that addresses Dampness and stagnation in the digestive tract from complementary angles. The combination of Shi Jun Zi's parasite-killing action with the Qi-moving herbs ensures that once parasites are killed, they are efficiently expelled rather than lingering in the intestines.

How to Prepare

Traditional preparation instructions for Shi Jun Zi Wan

Preparation of Shi Jun Zi Wan

Classical pill preparation: The Shi Jun Zi kernels are soaked and the black skin removed. Hou Po (Magnolia bark) is prepared by removing the outer bark and toasting with ginger juice. Chen Pi (tangerine peel) has the white pith removed. All four herbs (Shi Jun Zi Ren 30g, Hou Po 1g, Chen Pi 1g, Chuan Xiong 1g) are ground into a fine powder and formed into pills using refined honey, each pill about the size of a soapberry (皂子大).

Dosage: For children over 3 years old, take 1 pill dissolved in aged rice water (陈米汤). For infants 100 days old to 3 years, take half a pill dissolved in breast milk or thin rice water.

As decoction (alternative): The herbs may also be prepared as a decoction. Reduce doses proportionally to standard decoction quantities. Decoct in water, strain, and administer warm on an empty stomach.

Common Modifications

How practitioners adapt Shi Jun Zi Wan for specific situations

Added
Bing Lang

6-9g, strengthens the parasite-expelling action and promotes downward movement

Ku Lian Pi

6-9g, a powerful antiparasitic that enhances worm-killing effect

When the parasitic burden is heavy and pain is severe, Bing Lang and Ku Lian Pi are added to intensify the anthelmintic action and help expel dead worms more efficiently.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Shi Jun Zi Wan should not be used or requires extra caution

Avoid

Do not use in patients with no confirmed parasitic infection or food stagnation. The classical text Ben Cao Hui Yan warns that if there is no worm accumulation, taking this formula will inevitably cause harm.

Avoid

Do not consume hot tea while taking this formula. Shi Jun Zi (Fructus Quisqualis) combined with hot tea is classically documented to cause hiccups (呃逆) and diarrhea.

Caution

Use with caution in children with Spleen and Stomach deficiency-cold (脾胃虚寒). Ben Cao Hui Yan states that in such children, excessive use will provoke hiccups, and the formula should not be taken for prolonged periods.

Caution

Use with caution regarding dosage. Overdose of Shi Jun Zi can cause hiccups, dizziness, nausea, vomiting, and in severe cases cardiac rhythm disturbances. Never exceed the age-appropriate dose for children.

Caution

Use with caution in patients with pre-existing liver disease or impaired liver function, as Shi Jun Zi has mild toxicity and is metabolized through the liver.

Caution

Avoid hot, greasy, and hard-to-digest foods during treatment, as they can burden the Spleen and Stomach and counteract the formula's effects.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. While none of the herbs in Shi Jun Zi Wan are among the classically listed pregnancy-contraindicated substances, Chuan Xiong (Ligusticum chuanxiong) is a Blood-moving herb that should be used carefully in pregnant women. Additionally, Shi Jun Zi itself has mild toxicity and its safety during pregnancy has not been established. This formula is designed primarily for pediatric use, so pregnancy is rarely a relevant clinical scenario. If parasitic infection occurs during pregnancy, consult a qualified practitioner for safer alternatives.

Breastfeeding

There is limited classical or modern data on the transfer of Shi Jun Zi Wan constituents through breast milk. Since this is primarily a pediatric formula, it is not typically prescribed to breastfeeding mothers. If a nursing mother requires deworming treatment, caution is advised because the active compounds of Shi Jun Zi (particularly quisqualic acid) may potentially pass into breast milk. The formula's aromatic and Qi-moving herbs (Hou Po, Chen Pi, Chuan Xiong) are generally considered mild, but their effects on lactation have not been formally studied. Consult a qualified practitioner before use during breastfeeding.

Children

Shi Jun Zi Wan is specifically designed as a pediatric formula. Classical dosing is weight- and age-based: - Infants 100 days to 3 years: half a pill, dissolved in breast milk or thin rice water. - Children over 3 years: 1 pill, dissolved in aged rice water. When using Shi Jun Zi kernels alone (as chewed or in powder), the traditional guideline is 1 to 1.5 kernels per year of age per day, with a strict maximum of 20 kernels daily regardless of age. Overdosing in children is the primary safety concern. Excessive Shi Jun Zi can cause hiccups (呃逆), dizziness, nausea, vomiting, and in rare cases abnormal heart rhythm. If hiccups occur after taking the formula, classical remedies include sipping plain rice water, chewing Gan Cao (licorice root), or drinking Ding Xiang (clove) tea. Do not give with hot tea, as this combination classically provokes hiccups and diarrhea. Treatment courses are typically short (3 days), and the formula should be taken on an empty stomach for best efficacy against intestinal parasites.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Shi Jun Zi Wan

No well-documented pharmaceutical drug interactions have been established for Shi Jun Zi Wan in peer-reviewed literature. However, the following theoretical considerations apply:

  • Anthelmintic medications: If combining with pharmaceutical dewormers (e.g. albendazole, mebendazole), there is a theoretical risk of additive gastrointestinal side effects (nausea, abdominal pain, diarrhea). Avoid concurrent use without medical supervision.
  • Chuan Xiong (Ligusticum chuanxiong): This herb has mild blood-moving and vasodilating properties. Patients on anticoagulant or antiplatelet medications (e.g. warfarin, aspirin) should use with caution, though the amount in this formula is very small (1g in the classical dose).
  • Hot beverages containing tannins (tea): While not a pharmaceutical interaction, the classical prohibition against drinking hot tea with Shi Jun Zi is well documented and should be observed. Tea tannins may interact with the active alkaloids and cause gastrointestinal distress.

Usage Guidance

Practical advice for getting the most out of Shi Jun Zi Wan

Best time to take

On an empty stomach, ideally early morning before breakfast (空腹, traditionally at the fifth watch / dawn).

Typical duration

Short-course treatment: typically 3 days for parasite expulsion, reassessed after each course. May be repeated after a 3-5 day break if needed.

Dietary advice

Avoid drinking hot tea while taking this formula, as this is a strongly emphasized classical dietary prohibition (食忌). The combination of Shi Jun Zi with tea causes hiccups and diarrhea. Avoid greasy, oily, and hard-to-digest foods during treatment, as they burden the Spleen and Stomach and interfere with the formula's action. Favor easily digestible, warm foods such as rice porridge (congee), steamed vegetables, and light soups. These support the Spleen and Stomach while the formula works to expel parasites and resolve food stagnation. Avoid raw, cold foods and excessive sweets, which can worsen dampness and food accumulation in children.

Shi Jun Zi Wan originates from Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方), Shaoxing supplementary additions section (绍兴续添方) Song dynasty (宋代), circa 1148 CE (Shaoxing period additions)

Classical Texts

Key passages from the classical Chinese medical texts that first described Shi Jun Zi Wan and its clinical use

Classical Quotes on Shi Jun Zi Wan

From the Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方):

「治小儿五疳,脾胃不和,心腹膨胀,时复疞痛,不进饮食,渐致羸瘦。」
Translation: "Treats the five types of childhood malnutrition (gan), disharmony of the Spleen and Stomach, distension of the chest and abdomen, recurring pain, refusal of food and drink, and gradual emaciation."

From the Xiao Er Yao Zheng Zhi Jue (小儿药证直诀), a case recorded by Qian Yi:

「脾虚泻……当即补脾。若以使君子丸即缓。」
Translation: "Spleen-deficiency diarrhea... the Spleen must be supplemented immediately. If Shi Jun Zi Wan is used, [the condition] will gradually ease."

From the Ben Cao Gang Mu (本草纲目) by Li Shizhen, on the chief herb:

「此物味甘气温,既能杀虫,又益脾胃,所以能敛虚热而止泻痢,为小儿诸病要药。」
Translation: "This substance is sweet in flavor and warm in nature. It can both kill parasites and benefit the Spleen and Stomach, which is why it can restrain deficiency-heat and stop diarrhea and dysentery. It is an essential medicine for all manner of childhood diseases."

From the Ben Cao Jing Shu (本草经疏):

「使君子,为补脾健胃之要药……不苦不辛,而能杀疳蛔,此所以为小儿上药也。」
Translation: "Shi Jun Zi is an essential medicine for supplementing the Spleen and strengthening the Stomach... Neither bitter nor acrid, yet able to kill parasites causing malnutrition. This is what makes it a superior medicine for children."

Historical Context

How Shi Jun Zi Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Historical Context of Shi Jun Zi Wan

Shi Jun Zi Wan first appears in the Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方), the Song dynasty's official government formulary, within the "Shaoxing supplementary additions" (绍兴续添方) section for pediatric diseases. This places its formal codification around 1148 CE or shortly after, when the formulary was expanded and renamed. A related but distinct version also appears in the Bo Ji Fang (博济方, Volume 4), which includes Gan Cao and Da Zao in the composition and lists a slightly different set of indications.

The formula became closely associated with Qian Yi (钱乙, c. 1032-1113), the renowned Song dynasty pediatrician honored as the "ancestor of pediatric medicine" (幼科之鼻祖). In his Xiao Er Yao Zheng Zhi Jue (小儿药证直诀), Qian Yi records using Shi Jun Zi Wan in multiple clinical cases to supplement the Spleen and calm the Stomach after episodes of vomiting, diarrhea, and chronic infantile convulsions. He paired it with formulas like Yi Huang San for warming and supplementing the middle, demonstrating the pill's role not just as a dewormer but as a gentle Spleen-supporting remedy for fragile children.

The herb Shi Jun Zi itself has an interesting name origin: according to tradition, a provincial official (使君, "Imperial Commissioner") first discovered the fruit's anthelmintic properties by feeding it to children, hence the name "the Envoy's fruit" or "Commissioner's seed." Li Shizhen in the Ben Cao Gang Mu noted Shi Jun Zi as uniquely sweet among parasite-killing herbs, which are typically bitter or acrid, making it especially suitable for pediatric use.