Gui Shao Di Huang Tang

Angelica, Peony, and Rehmannia Decoction · 歸芍地黃湯

Also known as: Gui Shao Di Huang Wan (归芍地黄丸, pill form from Jǐng Yuè Quán Shū), Dang Gui Shao Yao Di Huang Tang

A classical formula that nourishes the Liver and Kidneys, replenishes Blood, and clears mild deficiency Heat. It is commonly used for dizziness, tinnitus, dry throat, afternoon tidal fever, lower back and leg soreness, and menstrual irregularities caused by combined Liver and Kidney weakness with insufficient Blood and Yin.

Origin Zhèng Yīn Mài Zhì (《症因脉治》Pathology, Causes, Pulse, and Treatment), Volume 2, by Qin Jingming (秦景明), Qīng dynasty — Qīng dynasty, circa 1706 CE
Composition 8 herbs
Shu Di Huang
King
Shu Di Huang
Dang Gui
Deputy
Dang Gui
Bai Shao
Deputy
Bai Shao
Shan Zhu Yu
Deputy
Shan Zhu Yu
Shan Yao
Assistant
Shan Yao
Mu Dan Pi
Assistant
Mu Dan Pi
Fu Ling
Assistant
Fu Ling
Ze Xie
Envoy
Ze Xie
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Gui Shao Di Huang Tang is designed to correct these specific patterns.

Why Gui Shao Di Huang Tang addresses this pattern

When the Liver and Kidneys become depleted of Yin, the body loses its ability to moisten, cool, and anchor its internal functions. The Kidneys, as the root of Yin for the entire body, fail to nourish the Liver, and the Liver in turn cannot properly store Blood or keep its Yang in check. This manifests as dizziness, tinnitus, dry eyes, soreness in the lower back and knees, and a sensation of Heat in the afternoon or at night (when Yin is naturally at its lowest). Gui Shao Di Huang Tang addresses this through its core Liu Wei Di Huang Wan structure, which nourishes Kidney Yin and clears deficiency Heat through its balanced "three supplement, three drain" architecture. The addition of Dang Gui and Bai Shao strengthens this approach by also replenishing Liver Blood, recognizing that in clinical reality, Liver-Kidney Yin deficiency almost always involves some degree of Blood insufficiency. The formula thereby restores the Yin-Blood foundation that the Liver and Kidneys share.

A practitioner would look for one or more of these signs

Dizziness

Especially with a sense of lightheadedness upon standing

Tinnitus

Low-pitched ringing or buzzing in the ears

Lower Back Pain

Soreness and weakness in the lower back and knees

Night Sweats

Sweating during sleep due to Yin failing to contain fluids

Dry Mouth

Dry throat, especially in the afternoon or evening

Insomnia

Difficulty sleeping due to deficiency Heat disturbing the spirit

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Gui Shao Di Huang Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, the ability to conceive depends on the health of the Kidneys (which govern reproduction and store essence), the Liver (which stores Blood and regulates the menstrual cycle), and the Chong and Ren extraordinary vessels (which directly nourish the uterus). When Kidney Yin is depleted, the body lacks the foundational material to produce healthy follicles and build a receptive uterine lining. When Liver Blood is also insufficient, the menstrual cycle becomes irregular or scanty, and the uterus is undernourished. The follicular phase of the menstrual cycle, in particular, is understood as a time when Yin and Blood must build to prepare for ovulation. If this building phase is weak, fertility is compromised.

Why Gui Shao Di Huang Tang Helps

Gui Shao Di Huang Tang directly targets the follicular phase by nourishing Kidney Yin (through Sheng Di Huang, Shan Zhu Yu, and Shan Yao) and building Liver Blood (through Dang Gui and Bai Shao). Modern clinical practice frequently uses this formula during days 5-12 of the menstrual cycle to support follicular development and endometrial growth. Research has shown that the formula's ingredients may promote uterine blood vessel development (angiogenesis) and positively influence estrogen and progesterone receptor expression, providing a potential biological basis for its traditional use in fertility support.

Also commonly used for

Menstrual Irregularity

Scanty, delayed, or absent periods from Blood and Yin insufficiency

Dizziness

Related to Liver-Kidney Yin deficiency

Tinnitus

Chronic type associated with Kidney Yin deficiency

Night Sweats

Due to Yin deficiency failing to contain fluids

Chronic Hepatitis

Liver-Kidney Yin deficiency type

Amenorrhea

Blood deficiency type with dull aching pain

Osteoporosis

Associated with Kidney Yin and essence deficiency

What This Formula Does

Every TCM formula has a specific set of actions — here's what Gui Shao Di Huang Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Gui Shao Di Huang Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Gui Shao Di Huang Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Gui Shao Di Huang Tang works at the root level.

Gui Shao Di Huang Tang addresses a pattern of combined Liver and Kidney Yin deficiency with concurrent Blood insufficiency. In TCM theory, the Kidneys store Essence (Jing) and are the root of Yin for the entire body, while the Liver stores Blood and depends on Kidney Yin to nourish it. When Kidney Yin becomes depleted through chronic illness, overwork, emotional strain, or the natural aging process, the Liver loses its source of nourishment. The Liver then fails to store Blood adequately, and Liver Blood becomes deficient alongside Kidney Yin.

This dual deficiency produces a characteristic cluster of symptoms. Insufficient Yin means the cooling, moistening aspect of the body is weakened, allowing empty Heat (deficiency Heat) to rise. This manifests as afternoon tidal fevers, night sweats, dry mouth and throat, and a flushed feeling. Meanwhile, Blood deficiency leads to poor nourishment of the head, eyes, and Heart: dizziness, blurred vision, heart palpitations, insomnia, and a pale or sallow complexion appear. In women, Liver Blood deficiency commonly disrupts menstruation, leading to scanty periods, delayed cycles, or amenorrhea. The Yin deficiency at the root level also weakens the lower back and knees (the domain of the Kidneys), producing soreness and weakness in those areas, as well as heel pain.

Because the Liver and Kidneys share a common Yin source (a classical principle known as "Liver and Kidney share the same origin," or gān shèn tóng yuán 肝肾同源), deficiency in one organ inevitably affects the other. The formula works by replenishing Kidney Yin at its source while simultaneously nourishing Liver Blood, thereby addressing both the root cause and its downstream consequences.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly sweet and sour with mild bitter notes. Sweet to tonify and nourish, sour to astringently preserve Yin and Blood, and mildly bitter to clear Deficiency Heat.

Channels Entered

Ingredients

8 herbs

The herbs that make up Gui Shao Di Huang Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 15 - 24g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Gui Shao Di Huang Tang

As the chief herb at the highest dosage, Sheng Di Huang nourishes Yin, cools Blood, and generates fluids. It replenishes the depleted Kidney and Liver Yin that forms the root of this pattern, while its cooling nature helps clear deficiency Heat.
Deputies — Assists and enhances the King
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 9 - 12g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Gui Shao Di Huang Tang

Nourishes and activates Blood, softens the Liver, and supports the generation of new Blood. Together with Bai Shao, it extends the formula beyond pure Yin nourishment into Blood-level nourishment, making it especially suitable when Blood deficiency accompanies Yin deficiency.
Bai Shao

Bai Shao

White peony root

Dosage 9 - 12g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen

Role in Gui Shao Di Huang Tang

Nourishes Blood and preserves Yin, softens the Liver and restrains Liver Yang. It works alongside Dang Gui to strengthen Blood-nourishing capacity and helps prevent the rising of unanchored Yang that can cause dizziness and headache when Yin is depleted.
Shan Zhu Yu

Shan Zhu Yu

Asiatic cornelian cherry fruit

Dosage 9 - 12g
Temperature Slightly Warm
Taste Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Liver, Kidneys

Role in Gui Shao Di Huang Tang

Nourishes and astringes the Liver and Kidneys, secures the essence (Jing). Its sour and warm nature helps consolidate Kidney Yin and prevent further leakage of vital substances.
Assistants — Supports or moderates other herbs
Shan Yao

Shan Yao

Chinese yam

Dosage 9 - 12g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs, Kidneys

Role in Gui Shao Di Huang Tang

Tonifies the Spleen and nourishes the Kidneys. By strengthening the Spleen, it supports the digestive system's role in generating Blood and Qi, providing a foundation for the nourishing herbs to build upon.
Mu Dan Pi

Mu Dan Pi

Tree peony root bark

Dosage 6 - 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys

Role in Gui Shao Di Huang Tang

Clears Heat from the Liver, cools Blood, and mildly invigorates Blood circulation. It restrains the warmth of Shan Zhu Yu and helps clear any deficiency Heat that arises from Yin depletion.
Fu Ling

Fu Ling

Poria

Dosage 6 - 9g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Gui Shao Di Huang Tang

Strengthens the Spleen and drains Dampness through gentle diuresis. It prevents the rich, cloying nourishing herbs from creating stagnation, and supports Shan Yao in protecting digestive function.
Envoy — Directs the formula to its target
Ze Xie

Ze Xie

Water plantain rhizome

Dosage 6 - 9g
Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Kidneys, Urinary Bladder

Role in Gui Shao Di Huang Tang

Drains Kidney turbidity and clears Damp-Heat from the Lower Burner through urination. It prevents the heavy nourishing nature of Sheng Di Huang from becoming overly cloying and directs the formula's action downward to the Kidneys.

Why This Combination Works

How the herbs in Gui Shao Di Huang Tang complement each other

Overall strategy

This formula addresses a pattern where both the Liver and Kidneys are depleted of Yin and Blood, leading to deficiency Heat and inadequate nourishment of the sinews, eyes, ears, and reproductive system. The prescription strategy combines the foundational Kidney-Yin nourishment of Liu Wei Di Huang Wan with dedicated Blood-tonifying herbs to simultaneously restore both the root (Kidney Yin) and the branch (Liver Blood insufficiency).

King herbs

Sheng Di Huang serves as the sole King herb at the highest dosage. Its sweet, bitter, and cold nature enters the Heart, Liver, and Kidney channels, where it powerfully nourishes Yin, generates fluids, and cools Blood. By replenishing Kidney Yin, it addresses the deepest layer of deficiency. Its cooling property also directly counteracts the deficiency Heat that arises when Yin can no longer restrain Yang.

Deputy herbs

Dang Gui and Bai Shao are the two herbs that distinguish this formula from Liu Wei Di Huang Wan. Dang Gui nourishes and gently activates Blood, ensuring that new Blood is generated and flows smoothly rather than stagnating. Bai Shao nourishes Blood while also preserving Yin and calming the Liver, preventing Liver Yang from rising unchecked when Liver Blood is insufficient. Together they address Liver Blood deficiency, which standard Kidney-Yin formulas do not fully cover. Shan Zhu Yu complements them by astringently securing the Liver and Kidney essence, preventing the body's depleted resources from leaking further.

Assistant herbs

Shan Yao serves as a reinforcing assistant, supporting the Spleen and Kidneys to create a foundation for Blood and Yin production. Mu Dan Pi acts as a restraining assistant: it cools Blood and clears Liver Heat, preventing Shan Zhu Yu's warm, astringent nature from trapping Heat. Fu Ling is also a restraining assistant, draining Dampness and supporting the Spleen so the rich, heavy nourishing herbs do not overwhelm digestion.

Envoy herbs

Ze Xie directs the formula downward to the Kidneys by draining turbidity and promoting urination. It prevents the accumulation of pathological Dampness that could result from the formula's substantial nourishing action, and it ensures the cloying nature of Sheng Di Huang does not impair the body's fluid metabolism.

Notable synergies

The Dang Gui and Bai Shao pairing is a classical Blood-nourishing combination: Dang Gui moves and generates Blood while Bai Shao conserves and stabilizes it, together achieving smooth Blood flow without depletion. The classical "three supplements and three drains" structure inherited from Liu Wei Di Huang Wan (Sheng Di + Shan Zhu Yu + Shan Yao supplementing, while Ze Xie + Mu Dan Pi + Fu Ling drain) ensures that nourishment does not create stagnation, allowing the body to receive and distribute the formula's benefits efficiently.

How to Prepare

Traditional preparation instructions for Gui Shao Di Huang Tang

Place all herbs in a clay or enamel pot with approximately 600-800 mL of water. Soak for 30 minutes before cooking. Bring to a boil over high heat, then reduce to a gentle simmer and decoct for 30-40 minutes until approximately 300 mL of liquid remains. Strain and divide into two portions. Take one portion warm in the morning and one in the evening, ideally on an empty stomach. A second decoction can be made by adding fresh water and simmering again for 20-30 minutes.

Common Modifications

How practitioners adapt Gui Shao Di Huang Tang for specific situations

Added
Zhi Mu

9-12g, clears deficiency Heat and nourishes Yin

Huang Qi

6-9g, drains ministerial Fire from the Lower Burner

When deficiency Heat is prominent, adding Zhi Mu and Huang Bai (as in Zhi Bai Di Huang Wan) powerfully clears Fire from the Kidney and Liver levels without being overly cold, directly targeting the afternoon tidal fever and night sweats.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Gui Shao Di Huang Tang should not be used or requires extra caution

Caution

Spleen and Stomach deficiency with poor digestion, loose stools, or reduced appetite. The rich, cloying nature of Shu Di Huang (prepared Rehmannia) and the formula's overall Yin-nourishing character can further impair digestive function in those with weak Spleen Qi.

Caution

Patterns of excess Dampness, Phlegm-Damp accumulation, or significant fluid retention. The heavy, moistening herbs in this formula (particularly Shu Di Huang and Dang Gui) can worsen Dampness. If Dampness is present, the formula requires modification or should be avoided.

Caution

Yang deficiency with pronounced Cold signs such as cold extremities, clear profuse urination, and a pale tongue with white coating. This formula is designed for Yin and Blood deficiency and does not warm Yang. Use of Yin-enriching formulas in true Yang deficiency can further damage Yang.

Caution

Exterior pathogen invasion (common cold or flu) that has not been resolved. Tonifying formulas should generally not be used while an external pathogen is still active, as they can trap the pathogen inside the body.

Avoid

Known allergy or hypersensitivity to any of the eight herbs in the formula.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy and only under the guidance of a qualified practitioner. While the formula does not contain strongly prohibited herbs, Dang Gui (Chinese Angelica) has mild Blood-moving properties that could theoretically stimulate uterine activity. Mu Dan Pi (Moutan bark) is also traditionally used with caution in pregnancy due to its Blood-cooling and mildly Blood-moving nature. The formula is not absolutely contraindicated, but its use must be carefully evaluated against the individual's clinical needs.

Breastfeeding

There is insufficient evidence to confirm absolute safety during breastfeeding. The formula's ingredients are generally considered mild, and Shu Di Huang (prepared Rehmannia) and Dang Gui (Chinese Angelica) have a long tradition of postpartum use in TCM to replenish Blood. However, because the formula contains Ze Xie (Alisma), which promotes urination and may theoretically affect fluid balance and milk production, and because data on the transfer of active compounds through breast milk is lacking, breastfeeding mothers should only use this formula under professional guidance.

Children

This formula is not commonly prescribed for young children and is more suited to adolescents and adults. If used in children (generally over age 6), dosages should be reduced to approximately one-third to one-half of the adult dose, adjusted by the child's age and body weight. Children and adolescents should only take this formula under the supervision of a qualified practitioner. The cloying, rich nature of Shu Di Huang may cause digestive upset in children with weak digestion.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Gui Shao Di Huang Tang

Antihypertensive medications: Shu Di Huang (Rehmannia) has demonstrated mild blood-pressure-lowering effects in pharmacological studies. Combined use with antihypertensive drugs may produce an additive hypotensive effect, requiring blood pressure monitoring.

Antidiabetic medications: Rehmannia oligosaccharides have shown hypoglycemic activity in preclinical studies. Patients taking insulin or oral hypoglycemic agents should monitor blood sugar closely, as additive effects on blood glucose are possible.

Anticoagulant and antiplatelet drugs: Dang Gui (Chinese Angelica) contains ligustilide and ferulic acid, which have mild anticoagulant and Blood-moving properties. Concurrent use with warfarin, heparin, aspirin, or other blood thinners may increase bleeding risk.

Immunosuppressants: Rehmannia extracts have shown immunomodulatory activity. Patients taking immunosuppressive medications (e.g., cyclosporine, tacrolimus) should exercise caution, as the formula may alter immune function in unpredictable ways.

Diuretics: Ze Xie (Alisma) has mild diuretic properties. Combined use with pharmaceutical diuretics could lead to excessive fluid loss or electrolyte imbalances.

Usage Guidance

Practical advice for getting the most out of Gui Shao Di Huang Tang

Best time to take

Traditionally taken on an empty stomach with warm water or lightly salted warm water (淡盐汤), typically 30 to 60 minutes before meals, morning and evening.

Typical duration

Often taken for 4 to 8 weeks as a course of treatment, then reassessed by a practitioner. May be used longer for chronic deficiency conditions with periodic breaks.

Dietary advice

Avoid excessively greasy, fried, and heavy foods that may impair the Spleen's ability to transform and transport the formula's rich, nourishing ingredients. Limit cold and raw foods (ice cream, raw salads, cold drinks) which can weaken the Spleen and counteract the formula's tonifying effects. Favor warm, easily digestible foods such as congee, soups, steamed vegetables, and lightly cooked dark leafy greens. Foods that nourish Blood and Yin are supportive: black sesame seeds, goji berries, dark grapes, mulberries, eggs, and bone broth. Avoid excessive consumption of spicy, hot foods and alcohol, which can generate Heat and further deplete Yin.

Gui Shao Di Huang Tang originates from Zhèng Yīn Mài Zhì (《症因脉治》Pathology, Causes, Pulse, and Treatment), Volume 2, by Qin Jingming (秦景明), Qīng dynasty Qīng dynasty, circa 1706 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Gui Shao Di Huang Tang and its clinical use

《症因脉治》卷二 (Zhèng Yīn Mài Zhì, Volume 2) by Qín Jǐngmíng (秦景明):

The original text records this formula for the treatment of: "外感吐血,失血太多,脉芤而涩者" — "Vomiting of blood due to external pathogens, with excessive blood loss, and a pulse that is hollow (kōu) and rough (sè)."


《外科证治全书》(Wài Kē Zhèng Zhì Quán Shū):

This text extends the formula's indications to: "肝肾真阴不足,不能滋养荣卫,眼花耳鸣,口燥舌干,津液枯竭" — "True Yin insufficiency of the Liver and Kidneys, unable to nourish the Ying (nutritive) and Wei (defensive) aspects, with blurred vision, tinnitus, dry mouth and tongue, and depletion of body fluids."


《张仲景方方族》(Zhāng Zhòng Jǐng Fāng Fāng Zú):

Commentary on the formula states: "本方为扶正达邪之方,既可凉血止血,又可助新血化生" — "This formula supports the upright [Qi] to expel pathogenic factors; it can both cool the Blood to stop bleeding and help generate new Blood."

Historical Context

How Gui Shao Di Huang Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Gui Shao Di Huang Tang originates from the Zhèng Yīn Mài Zhì (《症因脉治》, "Symptoms, Causes, Pulses, and Treatments"), a clinical text written by the Ming dynasty physician Qín Jǐngmíng (秦景明). This work, organized around a systematic framework linking symptoms to their causes, pulse findings, and corresponding treatments, records the formula for external-pathogen-related vomiting of blood with Yin and Blood deficiency.

The closely related pill form, Gui Shao Di Huang Wan (归芍地黄丸), appears in the Jǐng Yuè Quán Shū (《景岳全书》, "Complete Works of Jingyue") by the great Ming dynasty physician Zhāng Jǐngyuè (张景岳, also known as Zhang Jiebin). Zhang Jingyue was the founder of the Warm Supplementation school (温补学派) and a towering figure in Chinese medical history. His emphasis on nourishing true Yin and Essence made formulas built on the Liu Wei Di Huang Wan framework central to his clinical practice. The pill form became one of the most widely used preparations in the Di Huang Wan family, extending the original Liu Wei Di Huang Wan's Kidney Yin-nourishing function to more fully address Liver Blood deficiency.

In modern clinical practice, Gui Shao Di Huang Tang has found particular application in gynecology, where it is used during fertility cycle therapy for the follicular phase (approximately days 6 to 11 of the menstrual cycle) to nourish Yin and Blood in preparation for ovulation. It is also commonly used for menopausal syndrome, primary hypertension with Liver-Kidney Yin deficiency, and chronic conditions where Blood deficiency and Yin depletion are the core pattern.