Jiu Xian San

Nine Immortals Powder · 九仙散

Also known as: Jiu Xian Yin (九仙饮), Jiu Xian Dan (九仙丹)

A classical formula for persistent, long-standing coughs that have weakened the lungs. It works by restraining the scattered Lung Qi while replenishing both Qi and Yin (the body's vital moisture), and is best suited for dry, lingering coughs with shortness of breath and spontaneous sweating. It should only be used when there is no active infection or heavy phlegm production.

Origin Wei Sheng Bao Jian (卫生宝鉴) by Luo Tianyi, recording Wang Zi Zhao's formula — Yuán dynasty, 1281 CE
Composition 9 herbs
Ying Su Ke
King
Ying Su Ke
Ren Shen
Deputy
Ren Shen
E Jiao
Deputy
E Jiao
Wu Wei Zi
Deputy
Wu Wei Zi
Wu Mei
Deputy
Wu Mei
Kuan Dong Hua
Assistant
Kuan Dong Hua
Chuan Bei Mu
Assistant
Chuan Bei Mu
Sang Bai Pi
Assistant
Sang Bai Pi
+1
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Jiu Xian San is designed to correct these specific patterns.

Why Jiu Xian San addresses this pattern

When chronic, unrelenting cough persists over weeks or months, it gradually exhausts the Lung's Qi. The Lungs lose their ability to contain and control the downward movement of Qi, leading to further coughing, shortness of breath, and spontaneous sweating (as Qi can no longer hold the pores closed). Jiu Xian San addresses this through its three-pronged astringent core (Ying Su Ke, Wu Wei Zi, Wu Mei) that firmly restrains the leaking Lung Qi, while Ren Shen directly replenishes the depleted Qi at its source. The assistant herbs Kuan Dong Hua and Sang Bai Pi restore the Lung's descending function, and Jie Geng re-establishes its disseminating function, together rebuilding the Lung's normal Qi dynamic.

A practitioner would look for one or more of these signs

Chronic Coughing

Long-standing cough that will not resolve, worse with exertion

Shortness Of Breath

Breathlessness, especially after bouts of coughing

Spontaneous Sweat

Sweating without exertion, indicating Qi can no longer secure the exterior

Eye Fatigue

General tiredness and weak voice from Qi depletion

Wheezing

Wheezing or gasping after prolonged coughing episodes

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Jiu Xian San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, chronic bronchitis is understood as a condition where repeated or prolonged coughing has gradually exhausted the Lung's Qi and Yin. The Lungs, weakened from sustained illness, lose their capacity to properly descend and contain Qi. This creates a vicious cycle: the weakened Lungs cannot suppress the cough reflex, and ongoing coughing further depletes the Lungs. When Yin is also consumed, the airways dry out, producing the characteristic dry or minimally productive cough with sticky sputum. The spontaneous sweating and breathlessness that accompany this picture indicate that the Lung's governing role over Qi and the body's protective exterior has been compromised.

Why Jiu Xian San Helps

Jiu Xian San breaks the self-perpetuating cycle of cough and depletion. The astringent trio of Ying Su Ke, Wu Wei Zi, and Wu Mei strongly restrains the leaking Lung Qi and halts the chronic cough. Ren Shen replenishes the depleted Qi that drives the weakness, while E Jiao restores the moistening Yin fluids of the Lungs. Kuan Dong Hua and Chuan Bei Mu address any residual Phlegm and direct Qi downward. Clinical reports have shown this formula effective for chronic bronchitis with cough, phlegm, shortness of breath, and sweating as primary symptoms.

Also commonly used for

Emphysema

With chronic cough, shortness of breath, and Lung Qi weakness

Asthma

Chronic asthma with Qi-Yin deficiency pattern, not during acute attacks

Pulmonary Tuberculosis

Chronic cough stage with Qi and Yin depletion, sticky sputum difficult to expectorate

Whooping Cough

Late-stage or post-infectious lingering cough with Lung deficiency

Laryngopharyngeal Cough

Throat-source cough (喉源性咳嗽) with chronic irritation

What This Formula Does

Every TCM formula has a specific set of actions — here's what Jiu Xian San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Jiu Xian San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Jiu Xian San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Jiu Xian San works at the root level.

This formula addresses a condition where prolonged, chronic coughing has exhausted the Lungs' capacity to function properly. In TCM, the Lungs govern the descent and dispersal of Qi and fluids throughout the body. When coughing persists for a long time — whether the original cause was an external pathogen, internal dryness, or another factor — it gradually damages the Lungs' ability to hold and contain their Qi. Think of it like a bellows that has been overworked until it can no longer maintain its seal: Lung Qi begins to leak out, unable to be restrained.

As Lung Qi scatters, the body loses its ability to manage the protective exterior, leading to spontaneous sweating. The Lungs' Yin (its moistening, nourishing fluids) is also consumed by the prolonged illness, resulting in scanty, sticky phlegm that is difficult to expectorate, and a dry, weakened cough. The pulse becomes rapid (reflecting Yin depletion and low-grade heat from fluid deficiency) and weak or thin (reflecting Qi exhaustion). This is the pattern of Qi and Yin dual deficiency of the Lungs — the body is caught in a vicious cycle where coughing depletes Lung Qi and Yin, and the depletion causes more uncontrolled coughing.

The formula breaks this cycle by simultaneously restraining the leaking Lung Qi (to stop the cough at its root), replenishing the depleted Qi and Yin (to restore the Lungs' substance), and gently directing Qi downward and transforming residual phlegm (to restore normal Lung function without trapping pathological products).

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Neutral

Taste Profile

Predominantly sour and astringent with sweet undertones — sour to astringe and restrain the Lungs, sweet to tonify Qi and nourish Yin, with mild bitter notes to direct Qi downward and transform phlegm.

Channels Entered

Lung Kidney Large Intestine

Ingredients

9 herbs

The herbs that make up Jiu Xian San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Ying Su Ke

Ying Su Ke

Opium poppy husk

Dosage 3 - 6g
Temperature Neutral
Taste Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Lungs, Large Intestine, Kidneys
Preparation Remove the cap (去顶), honey-roast until yellow (蜜炒黄)

Role in Jiu Xian San

The principal astringent herb in this formula, used at the highest dose. Its strongly astringent and sour nature powerfully restrains leaking Lung Qi and stops persistent coughing. It is the most effective single herb for arresting chronic, intractable cough by securing the Lungs.
Deputies — Assists and enhances the King
Ren Shen

Ren Shen

Ginseng root

Dosage 3 - 6g
Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys
Preparation May be decocted separately (另炖)

Role in Jiu Xian San

Powerfully tonifies Lung and Spleen Qi, addressing the root Qi deficiency caused by long-standing cough. Works alongside E Jiao to replenish both the Qi and Yin aspects of the Lungs.
E Jiao

E Jiao

Donkey-hide gelatin

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Lungs, Liver, Kidneys
Preparation Dissolve separately into strained decoction (烊化)

Role in Jiu Xian San

Nourishes Lung Yin and moistens dryness, directly addressing the Yin depletion caused by prolonged coughing. Complements Ren Shen by replenishing the fluid aspect while Ren Shen restores the Qi aspect.
Wu Wei Zi

Wu Wei Zi

Schisandra berry

Dosage 3 - 6g
Temperature Warm
Taste Sour (酸 suān), Sweet (甘 gān)
Organ Affinity Lungs, Heart, Kidneys

Role in Jiu Xian San

Sour and astringent, it restrains and gathers the dissipating Lung Qi. Works in concert with Wu Mei and Ying Su Ke to form a trio of astringent substances that firmly secure the Lungs.
Wu Mei

Wu Mei

Dark plum fruit

Dosage 3 - 6g
Temperature Neutral
Taste Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Liver, Spleen, Lungs, Large Intestine

Role in Jiu Xian San

Strongly sour and astringent, it restrains Lung Qi and generates fluids. Reinforces the astringent action of the King herb while also helping to nourish Yin through its fluid-generating property.
Assistants — Supports or moderates other herbs
Kuan Dong Hua

Kuan Dong Hua

Coltsfoot flower bud

Dosage 3 - 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs

Role in Jiu Xian San

Moistens the Lungs, directs Qi downward, and stops coughing. Prevents the strongly astringent herbs from over-constraining Lung Qi by gently directing it downward, while also transforming any residual Phlegm.
Chuan Bei Mu

Chuan Bei Mu

Sichuan fritillary bulb

Dosage 3 - 5g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Lungs, Heart

Role in Jiu Xian San

Clears Lung Heat, transforms Phlegm, and stops coughing. Its cool, moistening nature addresses any lingering Heat or sticky Phlegm that chronic coughing produces, balancing the formula's predominantly restraining strategy.
Sang Bai Pi

Sang Bai Pi

White mulberry root bark

Dosage 3 - 6g
Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Lungs, Spleen

Role in Jiu Xian San

Drains Lung Heat and directs Lung Qi downward to calm wheezing. Its descending nature complements Jie Geng's ascending action, restoring the normal up-and-down movement of Lung Qi.
Envoy — Directs the formula to its target
Jie Geng

Jie Geng

Platycodon root

Dosage 3 - 6g
Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs

Role in Jiu Xian San

Opens and disseminates Lung Qi, guides the other herbs upward to the Lungs, and helps to expel Phlegm. Though it has a dispersing action, it serves the crucial function of directing the entire formula to its target organ and preventing the astringent herbs from trapping pathogenic residues.

Why This Combination Works

How the herbs in Jiu Xian San complement each other

Overall strategy

This formula addresses chronic cough caused by Lung Qi and Yin depletion through a dual approach: restraining the scattered Lung Qi with astringent herbs while simultaneously replenishing Qi and Yin. A notable feature is the inclusion of Lung-disseminating and Phlegm-transforming herbs alongside the astringents, ensuring the Lungs are not over-locked and residual pathogenic factors are not trapped inside.

King herb

Ying Su Ke (Poppy Husk) is the King at the highest dose in the original formula (8 liang versus 1 liang for most other herbs). It is the single most powerful astringent for restraining Lung Qi and stopping cough, directly addressing the core problem of Lung Qi leaking outward due to prolonged coughing.

Deputy herbs

Four herbs serve as Deputies. Ren Shen tonifies the depleted Lung and Spleen Qi, treating the root deficiency. E Jiao nourishes Lung Yin and moistens dryness, addressing the fluid depletion from chronic cough. Together, Ren Shen and E Jiao restore both the Qi and Yin aspects of the Lungs. Wu Wei Zi and Wu Mei reinforce the King's astringent action with their sour, gathering nature, and Wu Mei additionally generates fluids.

Assistant herbs

Kuan Dong Hua (reinforcing assistant) moistens the Lungs and directs Qi downward, stopping cough while preventing the heavy astringency from stagnating Lung Qi. Chuan Bei Mu (reinforcing assistant) clears residual Lung Heat and transforms sticky Phlegm that accumulates from chronic coughing. Sang Bai Pi (reinforcing assistant) drains Lung Heat and descends Lung Qi to calm wheezing, complementing the formula's downward-directing action.

Envoy herb

Jie Geng guides the entire formula to the Lung system and disseminates Lung Qi. This is a strategically important inclusion: within a predominantly astringent formula, Jie Geng's gentle dispersing and ascending action prevents over-constriction and ensures the Lungs can still perform their normal function of disseminating and descending Qi.

Notable synergies

The trio of Ying Su Ke, Wu Wei Zi, and Wu Mei creates a powerful astringent core that restrains leaking Lung Qi from three angles. The pairing of Jie Geng (ascending, disseminating) with Sang Bai Pi (descending, draining) restores the Lung's normal up-and-down Qi dynamic. The overall structure exemplifies the principle of "restraining within dispersing, descending within ascending" (敛中有散, 降中寓升), with the balance tilted toward restraining and descending.

How to Prepare

Traditional preparation instructions for Jiu Xian San

Grind all nine herbs into a fine powder. Take 9g per dose, mixed with warm boiled water, twice daily. Stop taking once the cough has resolved. The formula can also be prepared as a decoction by reducing the original proportions accordingly and boiling in water.

Note: E Jiao (Donkey-hide Gelite) should be dissolved separately (melted into the strained liquid). Ying Su Ke (Poppy Husk) should be honey-roasted before use (remove the top cap, coat with honey, and dry-roast until yellow).

Common Modifications

How practitioners adapt Jiu Xian San for specific situations

Added
Zi Wan

6-9g, to moisten the Lungs and stop cough

Pi Pa Ye

9-12g, to direct Lung Qi downward and stop cough

Xing Ren

6-9g, to descend Lung Qi and relieve cough

When coughing is very intense, additional cough-suppressing herbs that descend Lung Qi reinforce the formula's core action without conflicting with its astringent strategy.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Jiu Xian San should not be used or requires extra caution

Avoid

External pathogen (Wind-Cold or Wind-Heat) cough at the acute stage. Using astringent herbs when an external pathogen is still present will trap the pathogen inside the body ('closing the door on the thief'), worsening and prolonging the illness.

Avoid

Cough with copious, profuse phlegm congesting the Lungs. The astringent nature of this formula would lock in the phlegm rather than expel it, obstructing Lung function further.

Avoid

Prolonged or excessive use. The chief herb Ying Su Ke (Poppy Husk) contains opiate alkaloids including morphine and codeine, which can cause physical dependence and addiction. In China, prescriptions containing it are limited to no more than 7 consecutive days and are regulated as narcotic medications. The formula should be stopped as soon as the cough improves.

Caution

Cough due to Liver Fire invading the Lungs or Phlegm-Heat patterns. These require clearing and draining strategies, not astringent and tonifying ones.

Caution

Patients with a history of substance dependence or opioid sensitivity, due to the opiate alkaloid content of Ying Su Ke (Poppy Husk).

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. Ying Su Ke (Poppy Husk), the chief herb used in the largest dosage, contains opiate alkaloids (morphine, codeine, thebaine) that cross the placental barrier and can affect fetal development. Chinese regulatory guidelines explicitly prohibit the use of Ying Su Ke in pregnant women. E Jiao (Donkey-Hide Gelatin) is generally safe in pregnancy, but the presence of Ying Su Ke makes the overall formula unsuitable. This formula should not be used by pregnant women under any circumstances.

Breastfeeding

Contraindicated during breastfeeding. Ying Su Ke (Poppy Husk) contains opiate alkaloids including morphine and codeine, which are known to transfer into breast milk. Even small amounts of these substances in breast milk can cause sedation, respiratory depression, and feeding difficulties in nursing infants. Neonates and young infants are particularly sensitive to opiates. Chinese pediatric guidelines explicitly prohibit Ying Su Ke use for infants and young children, and exposure through breast milk carries the same risks. This formula should not be used by breastfeeding mothers.

Children

Ying Su Ke (Poppy Husk) is strictly contraindicated in infants, neonates, and young children due to extreme sensitivity to its opiate alkaloid content (morphine, codeine), which can cause respiratory depression, excessive sedation, and potentially fatal complications. Chinese regulatory guidelines classify Ying Su Ke as a narcotic substance and prohibit its use in pediatric patients. Therefore, Jiu Xian San in its classical form should NOT be used in children. For pediatric chronic cough with Lung Qi and Yin deficiency, practitioners should consider alternative formulas that do not contain Ying Su Ke, or use a modified version with the Poppy Husk removed and replaced with safer astringent alternatives.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Jiu Xian San

Ying Su Ke (Poppy Husk) and CNS depressants: The opiate alkaloids (morphine, codeine, papaverine) in Poppy Husk may have additive sedative and respiratory depressant effects when combined with benzodiazepines, barbiturates, opioid analgesics, antihistamines, or alcohol. Concurrent use increases the risk of excessive sedation and respiratory depression.

Ying Su Ke and MAO inhibitors: Monoamine oxidase inhibitors can intensify and prolong the effects of opioid alkaloids, potentially causing dangerous spikes in blood pressure, serotonin syndrome-like reactions, or severe respiratory depression. This is a well-documented and potentially life-threatening interaction.

Ren Shen (Ginseng) and anticoagulants/antiplatelet drugs: Ginseng may reduce the effectiveness of warfarin and similar anticoagulants. Patients on blood-thinning medications should be monitored.

Ren Shen (Ginseng) and hypoglycemic agents: Ginseng can lower blood sugar levels, potentially enhancing the effect of insulin or oral hypoglycemic drugs and increasing the risk of hypoglycemia.

E Jiao (Donkey-Hide Gelatin) and anticoagulants: E Jiao has mild hemostatic properties and may theoretically interact with anticoagulant or antiplatelet medications, though clinical significance is unclear.

Usage Guidance

Practical advice for getting the most out of Jiu Xian San

Best time to take

Two to three times daily between meals, taken warm. The classical instruction states to take it with warm water (白汤点服) and to stop once the cough subsides (嗽住止后服).

Typical duration

Short-term use only: stop as soon as the cough is controlled. In China, Ying Su Ke prescriptions are limited to a maximum of 7 consecutive days due to narcotic regulations.

Dietary advice

Avoid cold, raw foods, iced beverages, and greasy or deep-fried foods, which can generate phlegm and further burden the already weakened Lungs. Spicy, hot, and drying foods (chili, strong alcohol, heavily roasted or smoked foods) should also be limited, as they can injure Lung Yin and aggravate the dry cough. Favor warm, easily digestible, moistening foods that support the Lungs: pear (steamed with a little rock sugar), white fungus (Tremella) soup, lily bulb (Bai He) congee, honey water, almonds, and well-cooked rice porridge. These foods gently nourish Lung Yin without producing excess phlegm.

Jiu Xian San originates from Wei Sheng Bao Jian (卫生宝鉴) by Luo Tianyi, recording Wang Zi Zhao's formula Yuán dynasty, 1281 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Jiu Xian San and its clinical use

Formula verse (方歌):
「九仙散中罂粟君,参胶梅味共为臣,款冬贝桑桔佐使,敛肺止咳益气阴。」
Translation: In Jiu Xian San, Poppy Husk is the sovereign; Ginseng, Donkey-Hide Gelatin, Mume, and Schisandra together serve as ministers; Coltsfoot, Fritillary, Mulberry Bark, and Platycodon are assistants and envoys — together they restrain the Lungs, stop coughing, and benefit Qi and Yin.

From Zhongyao Zhifa Yu Fangji (中医治法与方剂):
「久咳不已导致肺气不敛,法当敛肺;肺气不敛导致肺气虚损,又当补肺,只有补敛同施,才合肺气耗散病情。」
Translation: Prolonged coughing leads to Lung Qi that fails to restrain itself — the method should be to astringe the Lungs. When Lung Qi fails to restrain, it leads to Lung Qi depletion — one must also supplement the Lungs. Only by combining supplementation and restraint together does one match the disease pattern of Lung Qi dissipation.

Historical Context

How Jiu Xian San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Jiu Xian San ("Nine Immortal Powder") originates from a formula attributed to a physician named Wang Zizhao (王子昭), recorded in the Wei Sheng Bao Jian (卫生宝鉴, "Precious Mirror of Health"), compiled by the Yuan dynasty physician Luo Tianyi (罗天益, courtesy name Qianfu 谦甫) and first published in 1281. Luo Tianyi was a prominent student of Li Dongyuan (李东垣), one of the four great masters of the Jin-Yuan medical era, placing this formula squarely within the Yi Shui (易水) school tradition that emphasized internal organ deficiency as a root cause of disease. The formula is also commonly attributed to the Yi Xue Zheng Zhuan (医学正传, "True Lineage of Medicine").

The name "Nine Immortals" refers to the nine herbs in the formula, poetically suggesting that these medicines together possess almost miraculous power to halt an intractable chronic cough. The formula is notable for its bold use of Ying Su Ke (Poppy Husk) as the chief herb in the highest dosage — a controversial choice that reflects the severity of the condition it treats. Later commentators praised the formula's sophisticated structure: it combines astringent herbs (to restrain), tonifying herbs (to replenish), descending herbs (to direct Qi downward), and dispersing herbs (to open and ventilate), creating a formula where "restraint and dispersal coexist, descent and ascent work in tandem" (敛中有散,降中寓升). This elegant balance of opposing strategies within a single prescription is considered a hallmark of advanced formula design.