Jiang Zhi Yin

Lipid-Reducing Drink · 降脂饮

Also known as: Crataegus Combination (降脂饮, Lipid-Reducing Drink)

A modern TCM formula designed to support healthy cholesterol and lipid balance. It works by dissolving food stagnation (especially from rich, fatty diets), promoting blood circulation, draining dampness, and gently clearing accumulated turbidity from the body. It is commonly used for people with high cholesterol, fatty liver, or metabolic imbalances related to diet and lifestyle.

Origin Modern clinical formula (contemporary TCM hospital formulation) — Modern era, late 20th century
Composition 11 herbs
Shan Zha
King
Shan Zha
Jue Ming Zi
Deputy
Jue Ming Zi
He Shou Wu
Deputy
He Shou Wu
Hu Zhang
Assistant
Hu Zhang
Yin Chen
Assistant
Yin Chen
Chai Hu
Assistant
Chai Hu
Ze Xie
Assistant
Ze Xie
Yu Jin
Assistant
Yu Jin
+3
more
Explore composition
Available in our store
View in Store
From $39.00

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Jiang Zhi Yin is designed to correct these specific patterns.

Why Jiang Zhi Yin addresses this pattern

In TCM, elevated blood lipids are often understood as an accumulation of turbid phlegm and dampness within the blood vessels and tissues. When the Spleen fails to properly transform and transport fluids and nutrients, dampness accumulates and over time condenses into phlegm. This turbid phlegm circulates in the blood, creating what modern medicine recognizes as high cholesterol and triglycerides. Jiang Zhi Yin addresses this pattern through multiple pathways: Shan Zha dissolves food-derived turbidity at its source in the digestive tract, Yi Yi Ren strengthens the Spleen to correct the root cause of dampness production, Ze Xie and Yin Chen drain dampness through the urinary and hepatobiliary routes, and Da Huang pushes turbid waste downward and out through the bowels.

A practitioner would look for one or more of these signs

Hyperlipidemia

Elevated cholesterol or triglycerides

Obesity

Overweight, especially abdominal

Dyspepsia

Bloating and fullness after meals

Eye Fatigue

Heaviness and fatigue in the limbs

Nausea

Nausea or greasy taste in mouth

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Jiang Zhi Yin when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM does not have a historical category called 'hyperlipidemia' by name, but the condition maps closely to classical concepts of turbid phlegm (痰浊) and damp accumulation (湿滞). The condition typically arises from a combination of dietary excess (particularly rich, greasy, and sweet foods), insufficient physical activity, and constitutional weakness of the Spleen's transformative capacity. When the Spleen cannot properly process what is consumed, the unprocessed material accumulates as dampness, which over time thickens into phlegm and turbid fat. The Liver's role in smooth metabolic flow is also critical. If Liver Qi stagnates, it further impairs the transport and transformation of these substances. Over time, the turbid phlegm lodges in the blood vessels and obstructs circulation, leading to blood stasis.

Why Jiang Zhi Yin Helps

Jiang Zhi Yin addresses hyperlipidemia through a multi-layered approach that mirrors the condition's complex pathomechanism. Shan Zha, the King herb, dissolves the food-derived turbidity at its source and has well-documented pharmacological effects on reducing serum cholesterol and triglycerides. Jue Ming Zi and He Shou Wu support hepatic cholesterol metabolism. The damp-draining herbs (Ze Xie, Yin Chen, Yi Yi Ren) provide multiple elimination pathways for turbid dampness. Blood-moving herbs (Hu Zhang, Yu Jin) address the blood stasis component that develops in chronic hyperlipidemia. Da Huang in small dose promotes bowel elimination of lipid-laden waste. Modern research confirms that these herbs collectively influence cholesterol synthesis (via HMG-CoA reductase), absorption, LDL receptor expression, and bile acid conversion.

Also commonly used for

Atherosclerosis

Early-stage arterial plaque formation

Nephrotic Syndrome

Cluster of metabolic risk factors

Coronary Artery Disease

As adjunctive support for cardiovascular risk

What This Formula Does

Every TCM formula has a specific set of actions — here's what Jiang Zhi Yin does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Jiang Zhi Yin is primarily used to support these areas of health:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Jiang Zhi Yin works at the root level.

In TCM understanding, elevated blood lipids (hyperlipidemia) are not viewed as a standalone disease but as a manifestation of deeper imbalance, primarily involving the accumulation of Phlegm-Turbidity (痰浊) and Blood stasis (血瘀) in the vessels and tissues. The disease logic begins with the Spleen and Liver.

The Spleen is responsible for transforming and transporting the essence of food and water. When Spleen function weakens, whether from overindulgence in rich, greasy foods, sedentary lifestyle, or constitutional factors, it can no longer properly process fluids and nutrients. These unprocessed substances congeal into Dampness, which over time thickens into Phlegm-Turbidity. This "turbid fat" (脂浊) accumulates in the blood and tissues, corresponding closely to what modern medicine recognizes as elevated cholesterol and triglycerides.

Simultaneously, the Liver governs the smooth flow of Qi throughout the body. Emotional stress, frustration, or long-standing metabolic stagnation can cause Liver Qi to become constrained. When Qi stagnates, Blood circulation also slows, eventually leading to Blood stasis. Furthermore, stagnant Liver Qi impairs the Spleen's transformative function (the Liver "overacting" on the Spleen), worsening Phlegm-Dampness production. Over time, Phlegm and stasis bind together in the vessels, creating the sticky, obstructive pathology that underlies atherosclerosis and cardiovascular risk. Some patients also develop Damp-Heat as stagnant Phlegm and stasis generate pathological heat, or the Liver and Kidneys become depleted, adding a deficiency dimension to what is primarily an excess condition.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly sour, bitter, and bland. Sour (Shan Zha) to digest food stagnation, bitter (Da Huang, Hu Zhang, Yin Chen, Yu Jin, Chai Hu) to drain Dampness and clear Heat, bland (Ze Xie, Yi Yi Ren) to leach out Dampness through urination.

Ingredients

11 herbs

The herbs that make up Jiang Zhi Yin, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Shan Zha

Shan Zha

Hawthorn fruit

Dosage 15 - 30g
Temperature Slightly Warm
Taste Sour (酸 suān), Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Liver

Role in Jiang Zhi Yin

The chief herb of the formula. Shan Zha (Hawthorn Fruit) powerfully dissolves food stagnation, especially from greasy and fatty foods. It invigorates blood circulation, transforms accumulations, and has well-documented modern lipid-lowering effects. It directly addresses the core therapeutic target of reducing turbid lipids.
Deputies — Assists and enhances the King
Jue Ming Zi

Jue Ming Zi

Cassia seed

Dosage 9 - 15g
Temperature Slightly Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Liver, Large Intestine
Preparation Dry-fried (炒) to moderate cold nature

Role in Jiang Zhi Yin

Clears Liver Heat, brightens the eyes, and moistens the intestines to promote bowel movement. Strongly synergizes with Shan Zha to lower lipids. Dry-frying moderates its cold nature while retaining its lipid-lowering properties.
He Shou Wu

He Shou Wu

Fleeceflower Root

Dosage 9 - 15g
Temperature Slightly Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān), Astringent (涩 sè)
Organ Affinity Liver, Kidneys
Preparation Must use processed form (制何首乌); raw He Shou Wu is inappropriate here

Role in Jiang Zhi Yin

Tonifies Liver and Kidney, nourishes Blood and Essence. The processed form is used to provide a nourishing and stabilizing counterbalance to the many draining herbs in this formula, preventing excessive depletion. It also has documented cholesterol-regulating properties.
Assistants — Supports or moderates other herbs
Hu Zhang

Hu Zhang

Giant Knotweed Rhizome

Dosage 9 - 15g
Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Liver, Gallbladder, Lungs

Role in Jiang Zhi Yin

Invigorates blood, resolves stasis, clears heat, and resolves toxins. It addresses blood stasis, a key pathological factor in hyperlipidemia. Contains resveratrol, which has recognized anti-inflammatory and lipid-lowering properties.
Yin Chen

Yin Chen

Virgate Wormwood Herb

Dosage 10 - 15g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Liver, Gallbladder

Role in Jiang Zhi Yin

Clears damp-heat, particularly from the Liver and Gallbladder. Promotes bile secretion and supports healthy hepatic metabolism of lipids. Helps the body process and excrete turbid dampness that contributes to elevated blood fats.
Chai Hu

Chai Hu

Bupleurum root

Dosage 6 - 10g
Temperature Slightly Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Gallbladder, Lungs

Role in Jiang Zhi Yin

Courses Liver Qi and relieves stagnation. Liver Qi stagnation impairs the Liver's role in governing the smooth flow of Qi and the metabolism of fats. Chai Hu ensures that Qi flows freely, supporting the overall dispersing and transforming action of the formula.
Ze Xie

Ze Xie

Water plantain rhizome

Dosage 9 - 15g
Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Kidneys, Urinary Bladder

Role in Jiang Zhi Yin

Promotes urination and drains dampness. It leaches out turbid dampness through the urinary pathway, providing a direct route for the body to expel accumulated damp-turbidity that manifests as elevated blood lipids.
Yu Jin

Yu Jin

Turmeric tuber

Dosage 9 - 12g
Temperature Cold
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Lungs

Role in Jiang Zhi Yin

Invigorates blood and resolves stasis, moves Qi and resolves constraint. Yu Jin works on both the Qi and Blood levels to address the stagnation that accompanies turbid lipid accumulation. It also clears heat from the Liver and Gallbladder.
Yi Yi Ren

Yi Yi Ren

Job's Tears seed

Dosage 10 - 20g
Temperature Cool
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Spleen, Stomach, Lungs

Role in Jiang Zhi Yin

Strengthens the Spleen and leaches out dampness. Addresses the root Spleen deficiency that leads to dampness and phlegm accumulation. Also supports healthy metabolism of turbid substances.
Da Huang

Da Huang

Rhubarb root and rhizome

Dosage 3 - 6g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium
Preparation May be added in the last 5-10 minutes of decoction (后下) to preserve purgative effect; use small dose

Role in Jiang Zhi Yin

Purges heat accumulation and drives out stasis. Used in small dose to promote bowel movement and expel turbid waste through the intestines, providing a downward-draining exit for accumulated lipid-related stagnation. Also invigorates blood.
Envoy — Directs the formula to its target
Jin Ying Zi

Jin Ying Zi

Cherokee rose fruit

Dosage 9 - 12g
Temperature Neutral
Taste Sour (酸 suān), Sweet (甘 gān), Astringent (涩 sè)
Organ Affinity Kidneys, Urinary Bladder, Large Intestine

Role in Jiang Zhi Yin

Astringes and consolidates Kidney Essence. Serves as a restraining assistant and envoy to prevent the many draining and purging herbs (Ze Xie, Da Huang, Yin Chen) from excessively depleting the body's Essence and righteous Qi. This balancing role is critical in a formula heavily weighted toward elimination.

Why This Combination Works

How the herbs in Jiang Zhi Yin complement each other

Overall strategy

This formula addresses the complex pathomechanism of turbid lipid accumulation by simultaneously dissolving food stagnation, draining dampness and phlegm, invigorating blood circulation, and coursing Liver Qi. Because excessive draining can injure the body's vital resources, it also includes herbs that nourish and consolidate, creating a balanced approach to metabolic imbalance.

King herbs

Shan Zha (Hawthorn Fruit) is the undisputed King. As the herb with the largest dose, it directly targets the primary pathological product by dissolving food stagnation from rich, greasy diets and invigorating blood to prevent lipid-laden stasis in the vessels. Its dual action on both the digestive tract and the blood makes it ideally suited as the lead herb for turbid lipid conditions.

Deputy herbs

Chao Jue Ming Zi (dry-fried Cassia Seed) reinforces the King by clearing Liver Heat and promoting intestinal elimination of waste. Its lipid-lowering action has been extensively studied and it synergizes directly with Shan Zha. Zhi He Shou Wu (processed Fleeceflower Root) takes a different but essential deputy role: it tonifies Liver and Kidney, nourishing Blood and Essence. This prevents the formula's numerous draining herbs from leaving the body depleted, while also contributing its own cholesterol-regulating properties.

Assistant herbs

Several assistant herbs work from different angles. Hu Zhang and Yu Jin are reinforcing assistants that invigorate blood and resolve stasis, addressing the blood stasis component of the pathomechanism. Yin Chen Hao and Ze Xie are reinforcing assistants that drain damp-heat and turbid dampness through the bile and urinary pathways respectively. Chai Hu courses Liver Qi to ensure the smooth flow needed for proper lipid metabolism. Yi Yi Ren strengthens the Spleen to address the root cause of dampness production. Da Huang acts as a restraining assistant in small dose, providing a downward-purging exit for accumulated turbidity through the bowels without being overly harsh.

Envoy herbs

Jin Ying Zi (Cherokee Rose Fruit) serves as the formula's envoy and restraining element. Its astringent nature consolidates Kidney Essence, counterbalancing the strong draining and purging actions of Ze Xie, Da Huang, and other eliminating herbs. This prevents the formula from being purely dispersing and ensures the body's foundational resources are protected during the cleansing process.

Notable synergies

The Shan Zha and Jue Ming Zi pairing is the formula's central synergy, combining digestive dissolution with hepatic clearance for a two-pronged approach to lipid reduction. The Chai Hu and Yu Jin pairing ensures that both Qi stagnation and blood stasis in the Liver are addressed simultaneously. Yin Chen Hao and Ze Xie together create powerful damp-draining action through both the hepatobiliary and urinary systems, while Jin Ying Zi and He Shou Wu together protect the Kidney Essence and prevent the draining herbs from being over-depleting.

How to Prepare

Traditional preparation instructions for Jiang Zhi Yin

Place all herbs in a clay or ceramic pot and soak in approximately 600-800 mL of cold water for 30 minutes. Bring to a boil over high heat, then reduce to a gentle simmer and cook for 25-30 minutes. Strain the liquid and set aside. Add fresh water (approximately 400-500 mL) to the dregs and perform a second decoction for 20 minutes. Combine the two decoctions and divide into two portions. Drink one portion in the morning and one in the evening, preferably 30 minutes after meals. Da Huang (Rhubarb) may be added in the final 5-10 minutes of cooking if the practitioner wishes to preserve its purgative effect.

For granule preparations: dissolve approximately 4.5 g of concentrated granules in hot water and drink as tea, 2-3 times daily.

Common Modifications

How practitioners adapt Jiang Zhi Yin for specific situations

Added
Dan Shen

15-20g, powerfully invigorates blood and clears blood stasis in the Heart and vessels

Chuan Xiong

6-10g, moves blood and Qi upward to the head and chest

When blood stasis is the dominant presenting feature, adding Dan Shen and Chuan Xiong strengthens the formula's blood-invigorating capacity, particularly for vascular stasis manifesting as chest pain or headaches.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Jiang Zhi Yin should not be used or requires extra caution

Avoid

Pregnancy. The formula contains Da Huang (Rhubarb), Yu Jin (Curcuma), and Hu Zhang (Bushy Knotweed), all of which promote Blood movement and may stimulate uterine contractions. Da Huang also has a strong purgative effect.

Avoid

Pre-existing liver disease or liver insufficiency. The formula contains Zhi He Shou Wu (Processed Fleeceflower Root), which has documented potential for hepatotoxicity, particularly in individuals with compromised liver function. Liver function should be monitored during use.

Caution

Spleen and Stomach deficiency-cold with chronic loose stools or diarrhea. Several herbs in this formula are cool or cold in nature (Jue Ming Zi, Ze Xie, Da Huang, Hu Zhang, Yin Chen) and will further damage already-weak digestive function. The draining and purging strategy is inappropriate for deficient constitutions.

Caution

Blood deficiency or Yin deficiency without Phlegm-Dampness. This formula emphasizes draining, moving, and purging. Using it in a depleted patient without significant Phlegm, Dampness, or stasis could consume Yin and Blood further.

Caution

Active hemorrhage or heavy menstrual bleeding. The formula contains multiple Blood-invigorating herbs (Hu Zhang, Yu Jin, Shan Zha) that could worsen bleeding.

Caution

Concurrent use with anticoagulant or antiplatelet medications without professional supervision, due to the Blood-invigorating properties of multiple ingredients.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. Da Huang (Rhubarb) is a strong purgative that stimulates intestinal contractions and has been classically listed as a pregnancy-prohibited herb due to its potential to induce uterine contractions. Hu Zhang (Bushy Knotweed Rhizome) and Yu Jin (Curcuma Root) both invigorate Blood circulation and move stasis, which poses a risk of threatening pregnancy. He Shou Wu, even in processed form, carries a documented risk of hepatotoxicity, and the metabolic changes of pregnancy may increase susceptibility. The overall draining and purging nature of this formula is inappropriate for pregnancy, which requires supporting and stabilizing strategies.

Breastfeeding

Use with caution during breastfeeding and only under professional supervision. Da Huang (Rhubarb) contains anthraquinone compounds that are known to pass into breast milk and may cause loose stools or diarrhea in the nursing infant. He Shou Wu (Fleeceflower Root) has documented hepatotoxicity concerns, and it is unknown to what extent its potentially harmful compounds transfer into breast milk. The formula's overall draining and purging nature may also reduce the quality or quantity of breast milk. If lipid management is needed during breastfeeding, a practitioner should consider a gentler formula without Da Huang and He Shou Wu.

Children

This formula is generally not appropriate for children. It was designed for adult metabolic conditions (hyperlipidemia) that rarely affect pediatric populations. The formula contains Da Huang (Rhubarb), which has strong purgative effects that can easily cause diarrhea and electrolyte imbalance in children. He Shou Wu carries hepatotoxicity risks that may be more concerning in children with still-developing liver function. If a practitioner determines that a child or adolescent genuinely needs lipid management with TCM, the formula would require significant dose reduction (typically one-third to one-half of the adult dose depending on age) and close monitoring, but in practice a different, gentler approach would usually be preferred.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Jiang Zhi Yin

Anticoagulant and antiplatelet medications (e.g. warfarin, heparin, aspirin, clopidogrel): Multiple herbs in this formula invigorate Blood and transform stasis (Hu Zhang, Yu Jin, Shan Zha, Da Huang). Hu Zhang contains resveratrol, which has known antiplatelet effects. Concurrent use may increase bleeding risk. Close monitoring of INR/coagulation parameters is recommended if combined use is unavoidable.

Statin medications (e.g. atorvastatin, simvastatin, rosuvastatin): The formula targets similar cholesterol metabolism pathways (LDL receptor upregulation, HMG-CoA reductase modulation). While research on Jiang-Zhi-Ning suggests complementary mechanisms, combination use may have additive effects on liver enzyme stress. He Shou Wu's documented hepatotoxicity potential is of particular concern when combined with statins, which also carry hepatotoxic risk. Liver function monitoring is advised.

Acetaminophen (paracetamol): Research has shown that stilbene glycoside (TSG), a key component of He Shou Wu, can exacerbate acetaminophen-induced hepatotoxicity by increasing CYP2E1, CYP3A4, and CYP1A2 expression. Concurrent use should be avoided.

Antihypertensive medications: Ze Xie (Alisma) has mild diuretic effects and Jue Ming Zi (Cassia Seed) has documented blood-pressure-lowering properties. Combined use with antihypertensives may produce additive hypotensive effects.

Diabetic medications: Da Huang and Jue Ming Zi may influence blood glucose levels. Patients taking insulin or oral hypoglycemics should monitor blood sugar more closely when using this formula.

Usage Guidance

Practical advice for getting the most out of Jiang Zhi Yin

Best time to take

30 minutes after meals, twice daily (morning and evening). Taking it after meals reduces potential gastrointestinal irritation from Da Huang and other bitter, draining herbs.

Typical duration

Typically taken for 4 to 12 weeks as a course of treatment, then reassessed by a practitioner based on lipid levels and symptom improvement. Long-term continuous use is not recommended without periodic liver function monitoring due to the presence of He Shou Wu.

Dietary advice

Avoid greasy, fatty, and fried foods, as these directly contribute to the Phlegm-Turbidity and food stagnation that this formula is designed to address. Reduce intake of rich meats, dairy, alcohol, and heavily processed foods. Favor light, easily digestible meals: leafy green vegetables, whole grains, mung beans, winter melon, radish, celery, seaweed, and moderate amounts of fish. These foods support the Spleen's transformative function and help resolve Dampness. Avoid excessive cold or raw foods, as these can impair the Spleen's digestive function even though the formula itself is cooling in nature. Room-temperature or warm foods are preferable. Limit sugar and refined carbohydrates, which in TCM terms generate Dampness and Phlegm. Moderate daily exercise is an important complement to the formula, as movement promotes the free flow of Qi and helps transform Phlegm-Dampness.

Jiang Zhi Yin originates from Modern clinical formula (contemporary TCM hospital formulation) Modern era, late 20th century

Classical Texts

Key passages from the classical Chinese medical texts that first described Jiang Zhi Yin and its clinical use

Jiang Zhi Yin (降脂饮) is a modern TCM formula rather than a classical prescription from the ancient canon. It does not have direct quotations from classical texts like the Shang Han Lun or Jin Gui Yao Lue.

However, the formula's core lipid-lowering herbs (Shan Zha, He Shou Wu, Jue Ming Zi) have roots in the classical tradition. Research on the closely related formula Jiang Zhi Ning attributes its herbal combination to the Qian Jin Fang (千金方, Prescriptions Worth a Thousand Gold) by Sun Simiao of the Tang Dynasty (652 CE), where these herbs were used together for conditions overlapping with what we now understand as hyperlipidemia. The classical TCM understanding of this condition falls under categories such as 痰证 (Phlegm patterns), 眩晕 (dizziness), 胸痹 (chest impediment), and 虚损 (consumptive deficiency).

A foundational classical principle underlying this formula's approach is from TCM internal medicine: 「肥人多痰湿」 ("Obese people tend to have abundant Phlegm-Dampness"), reflecting the understanding that excess body fat and elevated blood lipids are manifestations of Phlegm-Turbidity accumulation due to impaired Spleen transformation and Liver Qi stagnation.

Historical Context

How Jiang Zhi Yin evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Jiang Zhi Yin (降脂饮, "Lipid-Lowering Beverage") is a modern TCM formula developed in contemporary Chinese clinical practice to address hyperlipidemia, a disease category that did not exist by name in classical TCM but whose manifestations were recognized under broader categories such as Phlegm patterns, chest impediment, and dizziness.

The formula draws on a long tradition of using specific food-stagnation-resolving and Phlegm-transforming herbs for conditions related to excessive dietary fat. Several of its core herbs, particularly Shan Zha (Hawthorn), He Shou Wu (Fleeceflower Root), and Jue Ming Zi (Cassia Seed), appear together in the closely related classical formula Jiang Zhi Ning (降脂宁), which according to research was first recorded in Sun Simiao's Qian Jin Fang (Prescriptions Worth a Thousand Gold, 652 CE). The modern Jiang Zhi Yin expands on this core by adding herbs that address Liver Qi stagnation (Chai Hu, Yu Jin), clear Damp-Heat (Yin Chen, Hu Zhang), drain Dampness (Ze Xie, Yi Yi Ren), purge accumulation (Da Huang), and consolidate the Kidneys (Jin Ying Zi) to prevent excessive draining.

This formula reflects the modern TCM approach to "civilizational diseases" that has emerged since the mid-20th century, integrating traditional pattern differentiation with knowledge of modern disease mechanisms. It is now widely manufactured as a prepared granule, capsule, and tablet form for clinical convenience.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Jiang Zhi Yin

1

The Effects of Jiang-Zhi-Ning and Its Main Components on Cholesterol Metabolism (In vitro study, 2012)

Chen JX, Zhao HH, Ma XL, Han X, Luo LT, Wang LY, Han J, Liu B, Wang W. Evidence-Based Complementary and Alternative Medicine, 2012, Vol. 2012, Article ID 928234.

This laboratory study investigated how Jiang-Zhi-Ning (a closely related 4-herb formula sharing core ingredients with Jiang Zhi Yin) affects cholesterol processing in human liver cells. The researchers found that the formula's serum significantly increased the expression of LDL receptors (which help clear 'bad' cholesterol from the blood) and key cholesterol-processing enzymes, while decreasing enzymes involved in cholesterol storage. All four active components showed individual cholesterol-lowering effects through multiple pathways.

DOI
2

Lipid-Lowering and Antioxidant Activities of Jiang-Zhi-Ning in Traditional Chinese Medicine (Preclinical study, 2011)

Chen JX, Zhao HH, Yang Y, Liu B, Ni J, Wang W. Journal of Ethnopharmacology, 2011, Vol. 134(3), pp. 919-930.

This preclinical study using hyperlipidemic rats evaluated the lipid-lowering and antioxidant effects of Jiang-Zhi-Ning (sharing core herbs with Jiang Zhi Yin: Fleeceflower Root, Hawthorn, Lotus Leaf, and Cassia Seed). The formula demonstrated significant reductions in total cholesterol, triglycerides, and LDL-cholesterol, along with antioxidant activity, supporting its traditional use for cardiovascular protection.

DOI
3

Screening of Hypolipidemic Active Components in Jiang-Zhi-Ning and Its Preliminary Mechanism Research (Preclinical study, 2021)

Zhang Y, Li LH, Zhang JH, Lin TF, Jiang YY, Lin B. Journal of Ethnopharmacology, 2021, Vol. 272, Article 113926.

This study screened the active lipid-lowering components absorbed into rat blood after oral administration of Jiang-Zhi-Ning. Researchers identified key absorbed compounds responsible for the formula's cholesterol and triglyceride-lowering effects, providing evidence for its pharmacological mechanism at the molecular level.

DOI

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.