Formula Pill (Wan)

Bao He Wan

Preserve Harmony Pill · 保和丸

Also known as: Preserve Harmony Pill, Bao He Pill

A gentle, time-tested formula for the uncomfortable, heavy feeling after overeating or consuming rich, greasy foods. It helps break down accumulated food, relieves bloating, acid reflux, nausea, and belching, and restores normal digestive movement. Often described as 'digestive first aid' in Chinese medicine, it works by clearing the blockage rather than masking symptoms.

Origin 丹溪心法 (Dān Xī Xīn Fǎ, Teachings of Dān Xī) by Zhū Zhènhēng (朱震亨) — Yuán dynasty (元朝), ~1347 CE
Composition 7 herbs
Shan Zha
King
Shan Zha
Shen Qu
Deputy
Shen Qu
Lai Fu Zi
Deputy
Lai Fu Zi
Ban Xia
Assistant
Ban Xia
Chen Pi
Assistant
Chen Pi
Fu Ling
Assistant
Fu Ling
Lian Qiao
Assistant
Lian Qiao
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Bao He Wan is designed to correct these specific patterns.

Why Bao He Wan addresses this pattern

Bao He Wan is the representative formula for food stagnation in the Stomach (食滞胃脘证). The pathomechanism here is straightforward: overeating, eating too quickly, or consuming excessive rich and greasy foods overwhelms the Stomach and Spleen's capacity to transform and transport food. The undigested food accumulates in the middle burner, obstructing the Qi mechanism. When Qi cannot flow freely, there is fullness and distension. When the Stomach's descending function fails, turbid Qi rises, producing foul belching, acid reflux, nausea, and vomiting. When the Spleen's ascending function fails, clear Qi cannot rise, resulting in loose stools.

The formula directly addresses this by deploying three specialized digestive herbs as its core: Shan Zha (Hawthorn) as the chief herb excels at dissolving accumulations from meat and greasy foods; Shen Qu (Medicated Leaven) breaks down stale food and alcohol; and Lai Fu Zi (Radish Seed) descends Qi and relieves bloating from grain and flour-based foods. Together they cover all types of dietary excess. Ban Xia and Chen Pi then regulate Qi and dry Dampness to address the stagnation of the Qi mechanism and stop nausea. Fu Ling strengthens the Spleen and drains Dampness. Lian Qiao (Forsythia) clears the Heat that food stagnation readily generates and helps disperse accumulations. The overall effect is gentle but comprehensive, restoring the Stomach's harmony without harsh purgation, which is why the formula is named "Preserve Harmony."

A practitioner would look for one or more of these signs

Epigastric Fullness And Distension

Focal distension and fullness in the upper abdomen after eating

Acid Reflux

Belching with foul, rotten-smelling odor and sour regurgitation

Nausea

Nausea and aversion to food, especially at the sight or smell of food

Abdominal Pain

Abdominal distension and pain

Loss Of Appetite

Complete loss of appetite

Loose Stools

Loose, foul-smelling stools or diarrhea

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Bao He Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Food Stagnation in the Stomach Stomach and Intestine Food Stagnation with Dampness and Heat

TCM Interpretation

In TCM, functional dyspepsia maps most closely to the pattern of food stagnation obstructing the middle burner (中焦). The Stomach's primary role is to "receive" food and begin its breakdown, then send it downward; the Spleen's role is to transform and transport the nutrients upward. When either or both organs are overwhelmed, food sits in the Stomach without being properly processed. The Qi mechanism in the middle burner stalls: the Stomach cannot descend (causing fullness, nausea, and belching), and the Spleen cannot ascend (causing fatigue and loose stools).

Over time, the stagnant food generates Dampness and Heat, which further impairs the Spleen and Stomach's function, creating a self-reinforcing cycle. This explains why functional dyspepsia can become chronic even without any structural abnormality visible on endoscopy. The condition reflects a functional impairment of the digestive organs' Qi dynamics rather than tissue damage.

Why Bao He Wan Helps

Bao He Wan directly targets the core pathomechanism of functional dyspepsia by dissolving the accumulated food and restoring normal Qi flow in the middle burner. Shan Zha, Shen Qu, and Lai Fu Zi each break down different types of food accumulation (meat and fats, fermented and stale foods, and grain-based foods respectively), covering the full spectrum of dietary triggers. Lai Fu Zi is particularly important because it descends Stomach Qi, directly addressing the upward rebellion that causes nausea, belching, and reflux.

The formula also addresses the secondary consequences of stagnation: Ban Xia and Chen Pi regulate Qi and dry Dampness to relieve bloating and stop nausea; Fu Ling strengthens the Spleen's transport function and resolves fluid accumulation; and Lian Qiao clears Heat that the stagnation generates. Preclinical research has shown that the formula's constituents can promote gastric emptying and increase digestive enzyme activity, providing a biomedical rationale that complements the traditional explanation.

Also commonly used for

Chronic Gastritis

Superficial gastritis with food stagnation symptoms

Gastroenteritis

Acute gastroenteritis from dietary indiscretion

Acid Reflux

Gastroesophageal reflux related to food stagnation and overeating

Chronic Cholecystitis

When associated with food stagnation and difficulty digesting fatty foods

Diarrhea

Diarrhea caused by food stagnation, particularly in children

Nausea Or Vomiting

Nausea and vomiting from overeating

Hyperlipidemia

As an adjunctive approach when related to dietary excess and food accumulation

What This Formula Does

Every TCM formula has a specific set of actions — here's what Bao He Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Bao He Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Bao He Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Bao He Wan works at the root level.

The pattern that Bao He Wan addresses begins with a simple and common cause: eating too much, too fast, or too richly. When the Stomach receives more food than it and the Spleen can properly process, the undigested material stagnates in the middle burner (the digestive center). Rather than being transformed and transported as it should be, the food just sits there, blocking the normal flow of Qi up and down through the digestive tract.

This stagnation sets off a chain of consequences. Blocked Qi causes fullness, bloating, and distending pain in the upper abdomen. When the Stomach's natural downward movement is disrupted and Qi rebels upward, it produces belching with a rotten smell, acid regurgitation, nausea, and vomiting. If the Spleen's ability to lift clear Qi is also impaired, diarrhea may result. Meanwhile, stagnant food generates Dampness (a kind of heavy, sluggish metabolic byproduct) and, if it lingers, begins to produce Heat, much like a compost pile that generates warmth as it ferments. This is why the tongue coating becomes thick and greasy, and the pulse feels slippery.

The formula works because it addresses all these layers of the problem simultaneously: it directly breaks down the accumulated food, moves the blocked Qi back into its proper direction, dries the Dampness that has formed, and clears the Heat that the stagnation has generated. Critically, it does all this gently, without harsh purgation, which is why the formula is called "Preserve Harmony" — it restores digestive balance without further damaging an already overburdened system.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly sour and pungent with mild bitter notes — sour from Shan Zha to dissolve food accumulation, pungent from Chen Pi, Ban Xia, and Lai Fu Zi to move Qi and disperse stagnation, and bitter from Lian Qiao to clear Heat generated by the accumulation.

Target Organs

Channels Entered

Ingredients

7 herbs

The herbs that make up Bao He Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Shan Zha

Shan Zha

Hawthorn fruit

Dosage 15 - 18g
Temperature Slightly Warm
Taste Sour (酸 suān), Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Liver
Preparation Dry-fried (charred/焦山楂) to enhance digestive action

Role in Bao He Wan

Used in the largest dose, Shan Zha is the primary digestive herb. It excels at breaking down greasy, fatty, and meat-based food accumulation, directly addressing the core problem of food stagnation in the stomach.
Deputies — Assists and enhances the King
Shen Qu

Shen Qu

Medicated leaven

Dosage 6 - 9g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach
Preparation Dry-fried (炒神曲)

Role in Bao He Wan

A fermented medicinal that is particularly effective at digesting stale, fermented, and alcohol-related food residues. It complements Shan Zha by targeting a different category of food stagnation.
Lai Fu Zi

Lai Fu Zi

Radish seed

Dosage 6 - 9g
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Spleen, Stomach
Preparation Dry-fried (炒莱菔子)

Role in Bao He Wan

Promotes the downward movement of Qi and reduces bloating. It specializes in digesting grain and starch-based foods and helps dissolve phlegm turbidity caused by food stagnation.
Assistants — Supports or moderates other herbs
Ban Xia

Ban Xia

Pinellia tuber

Dosage 9 - 12g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs

Role in Bao He Wan

Dries dampness and transforms phlegm that accumulates when food stagnation impairs the Spleen's transport function. It also harmonizes the Stomach and stops nausea and vomiting by restoring the Stomach's normal downward-directing function.
Chen Pi

Chen Pi

Tangerine peel

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Spleen

Role in Bao He Wan

Moves Qi, resolves stagnation, and dries dampness. When food sits in the stomach, it blocks the normal flow of Qi. Chen Pi restores Qi circulation in the digestive tract, relieving bloating and distension.
Fu Ling

Fu Ling

Poria

Dosage 9 - 12g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Bao He Wan

Strengthens the Spleen and drains dampness through gentle diuresis. Food stagnation readily generates internal dampness, and Fu Ling addresses this secondary pathology while supporting the Spleen's transport and transformation capacity. It also helps stop diarrhea.
Lian Qiao

Lian Qiao

Forsythia fruit

Dosage 6 - 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Heart, Small Intestine

Role in Bao He Wan

Clears heat and disperses clumped stagnation. Accumulated food readily generates internal heat over time; Lian Qiao addresses this heat while its ability to scatter nodulations assists the digestive process. This is a clever preventive measure within the formula.

Why This Combination Works

How the herbs in Bao He Wan complement each other

Overall strategy

Bao He Wan is designed for food stagnation caused by overeating or dietary excess. The formula's gentle yet comprehensive approach simultaneously dissolves the accumulated food, restores the Stomach's normal digestive rhythm, and preemptively addresses the dampness and heat that food stagnation typically generates. Its name, "Harmony-Preserving Pill," reflects its mild, balanced nature: it resolves stagnation without harsh purgation.

King herb

Shan Zha (Hawthorn Fruit) is used in the largest dose (six liang in the original), making it clearly the lead herb. It is sour, sweet, and slightly warm, with a strong ability to dissolve all types of food accumulation, particularly greasy meat and rich fatty foods. As the King, it directly targets the core pathology of food stagnation blocking the middle burner.

Deputy herbs

Shen Qu (Medicated Leaven) and Lai Fu Zi (Radish Seed) serve as Deputies, each specializing in a different type of food residue. Shen Qu, being a fermented substance itself, excels at breaking down stale and alcohol-related food accumulation. Lai Fu Zi directs Qi downward and is particularly good at digesting starchy and grain-based foods while reducing abdominal bloating. Together with the King herb, these three Deputies ensure that virtually every category of food stagnation is addressed.

Assistant herbs

Four Assistant herbs handle the secondary consequences of food stagnation. Ban Xia (Pinellia) and Chen Pi (Tangerine Peel) are a classic pairing that moves Qi, dries dampness, and stops nausea and vomiting (reinforcing Assistants that restore Stomach function). Fu Ling (Poria) strengthens the Spleen and drains the dampness that inevitably accompanies food stagnation, also helping to stop diarrhea (reinforcing Assistant). Lian Qiao (Forsythia Fruit) is the most ingenious inclusion: it is slightly cold and bitter, clearing the heat that stagnant food generates as it "ferments" internally, and its ability to disperse clumping and nodulation actively helps break apart the food mass (restraining Assistant that prevents heat complications).

Notable synergies

The three digestive herbs (Shan Zha, Shen Qu, Lai Fu Zi) form a complementary trio that covers meat, alcohol, and grain foods respectively. Ban Xia, Chen Pi, and Fu Ling essentially recreate the core of Er Chen Tang (Two-Aged Decoction) minus Gan Cao, providing a built-in framework for resolving phlegm-dampness. The pairing of warming, descending digestive herbs with the cool, ascending Lian Qiao creates a balanced dynamic of movement within the formula, preventing the descending action from becoming excessive while ensuring heat does not build up from stagnation.

How to Prepare

Traditional preparation instructions for Bao He Wan

Classical pill form (original method): Grind all ingredients into a fine powder. Form into small pills using steamed bread (炊饼) as a binding agent, making each pill the size of a Wutong seed (about 6mm). Take 70 to 80 pills per dose (approximately 9g), on an empty stomach, swallowed with plain warm water.

Modern pill form: Grind all ingredients into powder and form water-bound pills. Take 6 to 9g per dose, twice daily, with warm water. Also available commercially as large honey pills (大蜜丸), taken 1 to 2 pills per dose.

Decoction form: The formula may also be prepared as a standard decoction. Reduce the original proportions proportionally (using the modern gram equivalents listed for each herb). Decoct in water for approximately 20 to 30 minutes. Take in two divided doses per day, between meals. The decoction form acts faster and is preferred for more acute or severe food stagnation.

Common Modifications

How practitioners adapt Bao He Wan for specific situations

Added
Zhi Shi

6 - 9g, strongly moves Qi and breaks through food accumulation

Bing Lang

6 - 9g, promotes downward movement and expels stagnation from the intestines

When food stagnation is heavy and the base formula's gentle action is insufficient, Zhi Shi and Bing Lang provide stronger Qi-moving and stagnation-breaking force to push the accumulated food through the digestive tract.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Bao He Wan should not be used or requires extra caution

Avoid

Spleen and Stomach deficiency without food stagnation. This formula is purely dispersing in nature and contains no tonifying herbs, so it should not be used when the digestive weakness stems from underlying deficiency rather than excess accumulation.

Caution

Pregnancy. The formula contains Lai Fu Zi (radish seed) and Shan Zha (hawthorn), both of which have downward-directing and Qi-moving properties that may be inappropriate during pregnancy. Use only under professional guidance.

Caution

Gluten or wheat allergy. Modern commercial preparations commonly include Shen Qu (medicated leaven, which contains wheat) and Mai Ya (barley sprouts). Individuals with celiac disease or wheat sensitivity should avoid these formulations.

Caution

Downward-distending abdominal pain with constipation. If the food stagnation has progressed to severe blockage with constipation and intense lower abdominal pain, a stronger purgative approach such as Zhi Shi Dao Zhi Wan may be more appropriate.

Caution

Indigestion caused by Liver, Heart, or Kidney disorders. This formula targets food stagnation in the Stomach and Spleen, not digestive symptoms arising from disharmony in other organ systems.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Shan Zha (hawthorn berry) has traditionally been noted as a concern during pregnancy due to its Qi-moving and Blood-activating properties. Lai Fu Zi (radish seed) has a strong downward-directing action on Qi. Ban Xia (pinellia), even in its prepared form (Zhi Ban Xia), is classically listed among herbs requiring caution in pregnancy. While Bao He Wan is not strongly contraindicated in the way that formulas containing Da Huang or Mang Xiao would be, it should only be used during pregnancy under the guidance of a qualified practitioner, and only for short-term, acute food stagnation.

Breastfeeding

Generally considered compatible with breastfeeding when used short-term for acute food stagnation. The herbs in Bao He Wan are mild and food-grade in nature (hawthorn, radish seed, tangerine peel, poria). No specific adverse effects on lactation or transfer of harmful substances through breast milk have been reported. However, Ban Xia (pinellia) is a potent herb, and prolonged or high-dose use during breastfeeding should be supervised by a qualified practitioner. If the nursing infant shows any unusual fussiness or digestive changes, discontinue and consult a practitioner.

Children

Bao He Wan is one of the most commonly used formulas for children in Chinese medicine, with a long history of pediatric application for food stagnation (食积) and milk accumulation (乳积) in infants and toddlers. Dosage should be reduced according to the child's age and weight. General guidelines: children under 3 years may take one-quarter to one-third of the adult dose; ages 3-7 may take one-third to one-half; ages 7-14 may take one-half to two-thirds. Granule or liquid preparations are preferred for young children who cannot swallow pills. The formula is well-suited for short-term use in children who have overeaten or show signs of food accumulation (bloating, foul-smelling stools, poor appetite, thick tongue coating). It should not be used long-term in children without professional guidance, as chronic digestive issues in children often reflect underlying Spleen deficiency that requires tonification rather than dispersal.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Bao He Wan

No significant drug interactions have been widely documented for Bao He Wan as a whole formula. However, several theoretical considerations apply based on the pharmacological properties of individual ingredients:

  • Shan Zha (hawthorn): Hawthorn has demonstrated mild cardiovascular effects in pharmacological studies, including blood pressure lowering and lipid reduction. It may theoretically potentiate the effects of antihypertensive medications or cardiac glycosides (e.g. digoxin). Individuals taking cardiovascular medications should inform their prescriber.
  • Acid-related interactions: Shan Zha is acidic in nature. The formula as a whole may theoretically affect gastric pH, which could influence the absorption of medications that are pH-sensitive (e.g. certain antibiotics, antifungals like ketoconazole, or iron supplements).
  • Ban Xia (pinellia): Prepared pinellia may have mild sedative properties and could theoretically enhance the effects of CNS depressants, though this interaction is not well-documented at standard formula doses.

As with all herbal formulas, it is advisable to take Bao He Wan at least 1-2 hours apart from pharmaceutical medications to minimize any potential interactions with drug absorption.

Usage Guidance

Practical advice for getting the most out of Bao He Wan

Best time to take

30 minutes to 1 hour after meals, or whenever symptoms of food stagnation are present.

Typical duration

Acute use: 1-3 days for occasional overeating; up to 5-7 days for more stubborn food stagnation. Not intended for long-term use.

Dietary advice

While taking Bao He Wan, avoid the very foods that caused the problem: greasy, fatty, fried, and heavily spiced foods should be minimized. Cold, raw foods (including salads, iced drinks, and raw fruit) should also be avoided, as they further burden a Stomach that is already struggling to process its contents. Alcohol should be restricted. Favor simple, warm, easily digestible foods such as plain rice porridge (congee), steamed vegetables, light soups, and small portions. Eat slowly and chew thoroughly. Avoid eating late at night. Resume a normal varied diet gradually once symptoms resolve.

Bao He Wan originates from 丹溪心法 (Dān Xī Xīn Fǎ, Teachings of Dān Xī) by Zhū Zhènhēng (朱震亨) Yuán dynasty (元朝), ~1347 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Bao He Wan and its clinical use

《丹溪心法》 (Dan Xi Xin Fa)
The original source text records the formula composition and its application for food stagnation. The classical Yi Fang Kao (医方考) commentary states that the formula's name, "Preserve Harmony" (保和), reflects its gentle approach: rather than attacking the body with harsh purgatives, it uses mild, balanced herbs to restore digestive harmony. As the commentary explains, other formulas use strong drugs to attack food stagnation, "which injures an already injured body," whereas Bao He Wan's ingredients are "mild and harmonious, following the principle of nourishment" (是方药味平良,补剂之例也,故曰保和).

《素问·痹论》 (Su Wen, Bi Lun)
The theoretical basis for the formula draws on the classical teaching: 「饮食自倍,肠胃乃伤」 — "When food and drink are consumed in excess, the intestines and Stomach are injured." This passage establishes the foundational principle that overeating directly damages the digestive organs, which is the core pathology that Bao He Wan addresses.

《医方集解》 (Yi Fang Ji Jie)
Wang Ang's commentary classifies this as a formula acting on the Foot Taiyin (Spleen) and Yangming (Stomach) channels, and explains the specific digestive roles of each ingredient: Shan Zha with its sour-warm nature dissolves greasy and fatty foods; Shen Qu with its pungent-warm fermented quality dissolves stale food and alcohol; and Lai Fu Zi descends Qi to eliminate grain and flour accumulation.

Historical Context

How Bao He Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Bao He Wan was created by Zhu Danxi (朱丹溪, also known as Zhu Zhenheng 朱震亨, 1281–1358), the last of the celebrated "Four Great Masters of the Jin-Yuan period" in Chinese medicine. Zhu Danxi is particularly famous for his theory that "Yang is often in excess, Yin is often deficient" (阳常有余,阴常不足), and for emphasizing the importance of dietary moderation and emotional balance. The formula first appeared in his work Dan Xi Xin Fa (丹溪心法, "Teachings from the Heart of Danxi"), volume 3, though the text was compiled and published posthumously, with the earliest known edition appearing in 1481, over a century after his death.

The formula's name, Bao He Wan (保和丸, "Preserve Harmony Pill"), reflects Zhu Danxi's gentle clinical philosophy. Rather than using harsh purgative methods to forcefully expel food accumulation, he designed a mild, balanced formula that gradually dissolves stagnation while protecting the Stomach. The Yi Fang Kao commentary praised this approach, noting that aggressive methods only compound the injury to an already overburdened digestive system. Structurally, the formula can be seen as a variation of Er Chen Tang (Two-Aged Herb Decoction) with the addition of food-resolving herbs, building on the established method of regulating Qi and transforming Phlegm-Dampness.

Over the centuries, Bao He Wan became one of the most widely used and modified formulas in Chinese medicine. The well-known derivative Da An Wan (大安丸) adds Bai Zhu (white atractylodes) to the base formula to simultaneously tonify the Spleen, addressing cases where food stagnation coexists with digestive weakness. Some later editions of the formula also include Mai Ya (barley sprouts) to enhance its ability to digest starches and grains. Today, Bao He Wan remains one of the most popular over-the-counter Chinese patent medicines for digestive complaints, available widely across China and in Chinese medicine practices worldwide.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Bao He Wan

1

Prescription Patterns of Chinese Herbal Products for Post-Surgery Colon Cancer Patients in Taiwan (Retrospective cohort study, 2014)

Chao TH, Fu PK, Chang CH, Chang SN, Chiahung Mao F, Lin CH. J Ethnopharmacol. 2014; 155(1):702-708.

A large population-based study using Taiwan's National Health Insurance database found Bao He Wan to be among the most commonly prescribed herbal formulas for gastrointestinal disorders in colon cancer patients after surgery, reflecting its widespread clinical use for digestive complaints.

2

Baohe Pill Decoction for Diarrhea Induced by High-Fat and High-Protein Diet Is Associated with the Structure of Lactase-Producing Bacterial Community (Preclinical, 2022)

Zhou K, Deng N, Yi X, Cai Y, Peng M, Xiao N. Front Cell Infect Microbiol. 2022; 12:1004845.

In a mouse model of diarrhea caused by a high-fat, high-protein diet, Bao He Wan reduced diarrhea by favorably modulating the intestinal composition of lactase-producing bacteria, suggesting a mechanism by which the formula may improve digestion through gut microbiome regulation.

PubMed
3

Effects of Baohe Pills on Blood Lipid in SD Rats with a High-Fat Diet on the Basis of Intestinal Microbiota (Preclinical, 2018)

Li YB, Ma XL, Li ZG, Jia HH, Liang Y, Hao GM. World Chin Med. 2018; 13:2107-2110+2116.

This animal study showed that Bao He Wan reduced total cholesterol, LDL cholesterol, and triglyceride levels in rats fed a high-fat diet, with the lipid-lowering effects correlated to changes in intestinal bacterial composition, pointing to gut microbiota as a key mediating mechanism.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.