Zhen Zhu Mu Wan

Mother-of-Pearl Pill · 珍珠母丸

Also known as: Zhen Zhu Dan (珍珠丹, Pearl Elixir)

A classical formula for calming the mind and improving sleep in people who experience restlessness, palpitations, dizziness, and insomnia due to an underlying pattern of Blood deficiency with overactive Liver Yang. It works by nourishing the Blood and Yin while anchoring rising Yang and settling the spirit, making it especially suited for anxiety-related sleep difficulties accompanied by dizziness.

Origin 普濟本事方 (Pǔ Jì Běn Shì Fāng) - Formulas of Universal Benefit from My Practice, by Xǔ Shūwēi (许叔微) — Sòng dynasty, ~1132 CE
Composition 10 herbs
Zhen Zhu Mu
King
Zhen Zhu Mu
Shu Di Huang
Deputy
Shu Di Huang
Dang Gui
Deputy
Dang Gui
Ren Shen
Deputy
Ren Shen
Suan Zao Ren
Assistant
Suan Zao Ren
Bai Zi Ren
Assistant
Bai Zi Ren
Fu Shen
Assistant
Fu Shen
Long Chi
Assistant
Long Chi
+2
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Zhen Zhu Mu Wan is designed to correct these specific patterns.

Why Zhen Zhu Mu Wan addresses this pattern

When Liver Blood and Yin are deficient, they fail to anchor Liver Yang, which then rises unchecked to disturb the head and spirit. This produces dizziness, headaches, irritability, and restless sleep. Zhen Zhu Mu Wan addresses this by using Zhen Zhu Mu, Long Chi, and Chen Xiang to subdue and redirect the rising Yang downward, while Shu Di Huang, Dang Gui, and Ren Shen replenish the Blood and Yin that anchor it. The formula treats both the excess above (rising Yang) and the deficiency below (depleted Blood and Yin), resolving the dizziness and calming the mind simultaneously.

A practitioner would look for one or more of these signs

Dizziness

Worse with stress or fatigue

Headaches

Distending or throbbing headache

Tinnitus

Ringing in the ears

Irritability

Restlessness and irritability

Insomnia

Difficulty falling or staying asleep

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Zhen Zhu Mu Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, healthy sleep depends on the spirit (Shen) being properly housed in the Heart, which requires adequate Heart Blood. The Liver also plays a key role: it stores Blood and houses the ethereal soul (Hun), which is said to return to the Liver during sleep. When Liver and Heart Blood are depleted, the spirit has no stable anchor and tends to float restlessly, producing difficulty falling asleep, disturbed dreams, and frequent waking. If Liver Yin is also deficient, uncontrolled Liver Yang flares upward and further agitates the Heart, creating a cycle of restlessness and insomnia. This type of insomnia is often accompanied by palpitations, dizziness, and a feeling of unease or startling easily.

Why Zhen Zhu Mu Wan Helps

Zhen Zhu Mu Wan directly addresses both sides of this insomnia pattern. The heavy, settling substances (Zhen Zhu Mu and Long Chi) anchor the wandering spirit, while the Blood tonics (Shu Di Huang, Dang Gui, Ren Shen) rebuild the depleted Blood that should nourish and root the spirit. The three spirit-calming herbs (Suan Zao Ren, Bai Zi Ren, and Fu Shen) specifically quiet the Heart and promote restful sleep. Shui Niu Jiao clears any residual Heart Heat that might be contributing to restlessness. Research has shown that when this formula was combined with conventional treatment for insomnia caused by stressful life events, it improved sleep quality scores and reduced anxiety compared to conventional treatment alone.

Also commonly used for

Palpitations

Fright palpitations worsening at night

Hypertension

When associated with Yin deficiency and Liver Yang rising

Neurasthenia

Nervous exhaustion with insomnia and emotional sensitivity

Dementia

Early-stage cognitive decline with Blood deficiency pattern

Epilepsy

Mild cases with Liver Wind and spirit disturbance

Menopausal Symptoms

Insomnia, palpitations, and dizziness during menopause

What This Formula Does

Every TCM formula has a specific set of actions — here's what Zhen Zhu Mu Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Zhen Zhu Mu Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Zhen Zhu Mu Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Zhen Zhu Mu Wan works at the root level.

This formula addresses a pattern where the Liver's Yin and Blood have become depleted, allowing Liver Yang to rise unchecked. In TCM theory, the Liver stores Blood and houses the Hun (the ethereal soul, roughly corresponding to the mind's capacity for dreaming, planning, and imagination). When Liver Blood is sufficient, the Hun is properly anchored and the person sleeps peacefully. When Blood and Yin are deficient, the Hun loses its anchor and becomes restless, especially at night when it should return to the Liver during sleep. This manifests as difficulty falling asleep, vivid or disturbing dreams, and a sense of being startled awake.

At the same time, the deficiency of Yin and Blood means there is not enough substance to weigh down and root the Liver Yang, which then floats upward. Rising Yang disturbs the Heart, which in TCM is the residence of the Shen (the conscious mind and spirit). The Heart depends on adequate Blood nourishment to remain calm; when Liver Yang invades upward and Heart Blood is also insufficient, the Shen becomes unsettled. This produces palpitations, anxiety, a feeling of restless agitation, dizziness, and poor sleep. The original text describes this as the Liver channel being "weakened by deficiency, internally receiving Wind" so that "upon lying down the Hun-soul scatters and cannot be held in place, resembling fright palpitations."

The fundamental problem is thus twofold: a root deficiency (insufficient Yin and Blood to nourish Liver and Heart) and a branch excess (Yang rising and disturbing the Spirit). Effective treatment must simultaneously nourish the root by replenishing Blood and Yin, while controlling the branch by anchoring the Yang and calming the Spirit.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly salty, sweet, and slightly bitter. The salty-heavy quality anchors rising Yang and calms the Spirit, the sweet herbs nourish Blood and Yin, and the slight bitterness directs Qi downward.

Target Organs

Channels Entered

Ingredients

10 herbs

The herbs that make up Zhen Zhu Mu Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Zhen Zhu Mu

Zhen Zhu Mu

Mother-of-Pearl Shell

Dosage 15 - 30g
Temperature Cold
Taste Salty (咸 xián), Sweet (甘 gān)
Organ Affinity Liver, Heart
Preparation Decoct first for 30 minutes (先煎); crush before decocting

Role in Zhen Zhu Mu Wan

The chief herb of the formula. Zhen Zhu Mu is salty, cold, and heavy, entering both the Heart and Liver channels. It calms the Liver, subdues rising Yang, and settles the spirit. It addresses both the root (Liver Yang rising) and the branch (disturbed spirit) of the condition.
Deputies — Assists and enhances the King
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 12 - 15g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Zhen Zhu Mu Wan

Nourishes the Blood and enriches Yin, addressing the root deficiency of Liver Blood and Yin that allows Yang to rise unchecked. As one of the largest-dosed herbs in the original formula, it provides substantial nutritive support.
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 9 - 12g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Zhen Zhu Mu Wan

Tonifies and invigorates the Blood. Working alongside Shu Di Huang, it nourishes Liver Blood and supports the Heart Blood, which is essential for anchoring the spirit. In TCM, the Liver stores Blood, and when Blood is sufficient, the ethereal soul (Hun) is properly housed at night.
Ren Shen

Ren Shen

Ginseng root

Dosage 6 - 9g
Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys

Role in Zhen Zhu Mu Wan

Powerfully tonifies Qi, supporting the generation of Blood and strengthening the Heart Qi. When Qi is sufficient, it helps the Heart maintain its function of housing the spirit (Shen), contributing to mental calm and stable sleep.
Assistants — Supports or moderates other herbs
Suan Zao Ren

Suan Zao Ren

Sour jujube seed

Dosage 9 - 12g
Temperature Neutral
Taste Sweet (甘 gān), Sour (酸 suān)
Organ Affinity Heart, Liver, Gallbladder

Role in Zhen Zhu Mu Wan

Nourishes the Heart and Liver, calms the spirit, and promotes sleep. Its sweet and sour flavour astringes and preserves Yin while quieting restlessness, directly targeting the insomnia and palpitations of the pattern.
Bai Zi Ren

Bai Zi Ren

Arborvitae seed

Dosage 9 - 12g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Kidneys, Large Intestine

Role in Zhen Zhu Mu Wan

Nourishes the Heart, calms the spirit, and gently moistens. It works synergistically with Suan Zao Ren and Fu Shen to form a trio of spirit-calming herbs that settle the Heart and ease anxiety.
Fu Shen

Fu Shen

Poria with Hostwood

Dosage 6 - 9g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Spleen

Role in Zhen Zhu Mu Wan

Calms the spirit and quiets the Heart. Fu Shen is the part of Poria that grows around the root of the host pine tree and is specifically indicated for restless spirit and palpitations, more so than regular Fu Ling.
Long Chi

Long Chi

Dragon Tooth Fossil

Dosage 9 - 15g
Temperature Cool
Taste Sweet (甘 gān), Astringent (涩 sè)
Organ Affinity Heart, Liver
Preparation Decoct first for 30 minutes (先煎); crush before decocting

Role in Zhen Zhu Mu Wan

Heavy and settling in nature, Long Chi anchors the spirit and calms fright. It reinforces the settling action of Zhen Zhu Mu and is particularly suited for palpitations and startling easily.
Shui Niu Jiao

Shui Niu Jiao

Water buffalo horn

Dosage 15 - 30g
Temperature Cold
Taste Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Heart, Liver, Stomach
Preparation Decoct first for at least 30 minutes (先煎)

Role in Zhen Zhu Mu Wan

Clears Heart Fire and cools the Blood. The original formula used rhinoceros horn (Xi Jiao), which is now banned; Water Buffalo Horn is the standard modern substitute. It addresses any Heat in the Heart that agitates the spirit, complementing the formula's calming and settling strategy.
Envoy — Directs the formula to its target
Chen Xiang

Chen Xiang

Agarwood

Dosage 1 - 3g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Kidneys
Preparation Added in last 5 minutes (后下); do not decoct long

Role in Zhen Zhu Mu Wan

Directs Qi downward and assists in subduing the upward movement of Liver Yang. Its aromatic, warm, and sinking nature helps the heavy minerals and shells in the formula descend effectively, reinforcing the formula's overall downward-directing strategy. It also regulates Qi flow to prevent the cloying nature of the rich Blood tonics from causing stagnation.

Why This Combination Works

How the herbs in Zhen Zhu Mu Wan complement each other

Overall strategy

This formula simultaneously addresses both the root and the branch of the condition. The root is Blood and Yin deficiency of the Heart and Liver, which fails to anchor Yang. The branch is the resulting upward flaring of Liver Yang that disturbs the spirit, producing restless sleep, palpitations, and dizziness. The prescription logic uses heavy, settling substances to subdue the Yang and calm the spirit (treating the branch), while rich Blood and Yin tonics replenish the deficiency (treating the root).

King herbs

Zhen Zhu Mu (Mother of Pearl) is the sole King. It is salty, cold, and heavy, entering both the Heart and Liver channels. Its weight and cold nature directly subdue rising Liver Yang and settle the disturbed spirit. Unlike Shi Jue Ming, which enters only the Liver channel, Zhen Zhu Mu uniquely reaches both the Heart and Liver, making it ideal when the spirit (housed in the Heart) is disturbed by Liver Yang rising.

Deputy herbs

Shu Di Huang and Dang Gui form the Blood-nourishing Deputy pair. Shu Di Huang enriches Liver and Kidney Yin, while Dang Gui tonifies and moves Blood. Together they address the root deficiency that allows Yang to rise. Ren Shen tonifies the source Qi, supporting Blood generation and strengthening the Heart's ability to house the spirit.

Assistant herbs

Three spirit-calming Assistants work together: Suan Zao Ren nourishes Heart and Liver Blood and promotes sleep (reinforcing); Bai Zi Ren nourishes and calms the Heart with its oily, moistening nature (reinforcing); Fu Shen specifically quiets the Heart spirit (reinforcing). Long Chi adds heavy mineral settling power to reinforce Zhen Zhu Mu's anchoring of the spirit. Shui Niu Jiao (substituting for the original Xi Jiao) clears Heart Fire that agitates the mind, addressing a secondary pathogenic factor (restraining).

Envoy herbs

Chen Xiang descends Qi and directs the formula's action downward, complementing the heavy settling herbs and preventing the formula's Qi from floating upward. It also moves Qi gently, preventing the rich Blood tonics from causing stagnation. The original preparation used Zhu Sha (Cinnabar) as a pill coating, which enters the Heart to further settle the spirit and focus the entire formula on the Heart.

Notable synergies

Zhen Zhu Mu paired with Long Chi creates a powerful anchoring effect that neither achieves alone: one from shell, one from fossilized bone, both heavy and settling. Suan Zao Ren, Bai Zi Ren, and Fu Shen form a classical trio for nourishing and calming the Heart spirit. Shu Di Huang plus Dang Gui is the foundational Blood-nourishing pair. Chen Xiang's downward Qi direction complements the heavy minerals' physical settling tendency, coordinating the formula's overall strategy of subduing and descending.

How to Prepare

Traditional preparation instructions for Zhen Zhu Mu Wan

Grind all ingredients into a fine powder. Blend with refined honey to form pills the size of Chinese parasol tree seeds (about 6mm diameter). Coat the pills with Cinnabar (Zhu Sha) powder. Take 40 to 50 pills per dose (approximately 6 to 9 grams), twice daily at midday and before sleep, swallowed with a warm decoction of Honeysuckle flower (Jin Yin Hua) and Mint (Bo He).

Modern adaptation: grind all herbs into fine powder, mix evenly, and use Shen Qu (medicated leaven) paste to form pills, coated with Zhu Sha. Take 6 grams per dose, three times daily with warm water. If prepared as a decoction, adjust herb dosages to standard modern ranges and decoct Zhen Zhu Mu first for 30 minutes before adding the other herbs.

Common Modifications

How practitioners adapt Zhen Zhu Mu Wan for specific situations

Added
Shi Jue Ming

15 - 30g, decoct first; strongly subdues Liver Yang

15 - 30g, decoct first; anchors Yang and calms the spirit
Ci Shi

15 - 30g, decoct first; weighs down rising Yang

When Liver Yang rising dominates the presentation with significant dizziness, headache, and tinnitus, additional heavy mineral substances are needed to strengthen the formula's Yang-subduing capacity.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Zhen Zhu Mu Wan should not be used or requires extra caution

Avoid

Insomnia or palpitations caused by Phlegm-Dampness or Phlegm-Heat patterns. This formula contains rich, cloying Blood-nourishing herbs that can worsen Dampness and obstruct the middle burner.

Avoid

Pregnancy. The formula traditionally includes Zhu Sha (cinnabar) as a pill coating, which contains mercury sulfide. Mercury crosses the placenta and poses serious risks to fetal development.

Avoid

Kidney or liver impairment. Cinnabar (Zhu Sha) is primarily accumulated in the kidneys after absorption. Individuals with compromised kidney or liver function face increased risk of mercury accumulation.

Caution

Spleen and Stomach deficiency with poor digestion. The heavy mineral substances (Zhen Zhu Mu, Long Chi) and enriching herbs (Shu Di Huang, Dang Gui) are difficult to digest and may cause epigastric discomfort, loose stools, or loss of appetite in those with weak digestive function.

Caution

Prolonged or unsupervised use. Due to the cinnabar coating, this formula should only be used for limited courses under professional guidance. Long-term use may lead to mercury accumulation and potential renal dysfunction.

Caution

Excess-type conditions with robust constitution. This formula is designed for deficiency patterns (Blood and Yin deficiency with Yang rising). It is not appropriate for purely excess-type agitation or insomnia from Liver Fire excess without underlying deficiency.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The traditional formulation uses Zhu Sha (cinnabar, mercury sulfide) as a pill coating. Mercury readily crosses the placenta and poses severe risks to fetal neurological development. Animal studies have demonstrated that even low-dose perinatal cinnabar exposure causes irreversible neurobehavioral defects in offspring. Additionally, the original formula contains Xi Jiao (rhinoceros horn), which in modern practice is substituted with Shui Niu Jiao (water buffalo horn). Even without the cinnabar coating, the heavy descending and Blood-moving nature of several ingredients makes this formula inappropriate during pregnancy. Pregnant individuals should avoid this formula entirely.

Breastfeeding

Contraindicated during breastfeeding if the traditional cinnabar-coated form is used. Mercury from cinnabar can enter breast milk and poses risks to infant neurological development, as developing nervous systems are particularly vulnerable to mercury's toxic effects. Infants have immature detoxification pathways that make mercury accumulation more dangerous. If a cinnabar-free version is prescribed by a qualified practitioner, the remaining herbal ingredients (Blood-nourishing and Spirit-calming herbs) are generally considered low risk during breastfeeding, though professional supervision is still advised. The enriching nature of the formula could theoretically affect milk quality or digestibility for the infant. Consult a qualified TCM practitioner before use.

Children

This formula should generally not be used in children, primarily due to the cinnabar (Zhu Sha) pill coating in the traditional formulation. Children's developing nervous systems and organs are particularly susceptible to mercury toxicity, and mercury accumulation occurs more readily in young bodies. Animal research has shown that perinatal and developmental exposure to even low doses of cinnabar results in irreversible neurobehavioral damage in offspring. If a cinnabar-free version is considered by a qualified practitioner for older children (above 6 years) with clear signs of Liver Yang rising and Blood deficiency causing sleep disturbance, the dosage should be reduced to approximately one-third to one-half the adult dose. The heavy mineral ingredients (Zhen Zhu Mu, Long Chi) should be used cautiously as they can be hard on young digestive systems. Pediatric use requires professional supervision and should be limited to short courses.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Zhen Zhu Mu Wan

Cinnabar (Zhu Sha) interactions: The traditional cinnabar coating contains mercury sulfide. Concurrent use with any medications metabolized through or toxic to the kidneys (e.g. aminoglycoside antibiotics, NSAIDs, certain antihypertensives) may compound nephrotoxic risk. Cinnabar should not be combined with bromides, iodides, or other halide-containing medications, as these may increase mercury bioavailability.

Sedative medications: This formula has calming and spirit-settling properties. Concurrent use with benzodiazepines, barbiturates, antihistamines, or other CNS depressants may produce additive sedation. Animal studies on cinnabar have shown prolongation of pentobarbital-induced sleeping time, suggesting pharmacological sedative effects that could potentiate pharmaceutical sedatives.

Ren Shen (Ginseng) interactions: Ginseng may interact with anticoagulants (e.g. warfarin) by affecting platelet aggregation. It may also affect blood glucose levels, potentially interacting with insulin or oral hypoglycemic agents. Ginseng has been reported to interact with MAO inhibitors.

Shu Di Huang (Prepared Rehmannia) and Dang Gui interactions: These Blood-nourishing herbs may have mild anticoagulant or antiplatelet effects and could theoretically enhance the effects of blood-thinning medications such as warfarin or aspirin.

Usage Guidance

Practical advice for getting the most out of Zhen Zhu Mu Wan

Best time to take

At midday and before bedtime, as specified in the original text (日午、夜卧服). The bedtime dose is especially important for addressing nighttime restlessness and insomnia.

Typical duration

Typically prescribed for 2-4 weeks, then reassessed. Due to the traditional cinnabar coating, prolonged continuous use is not recommended without professional monitoring.

Dietary advice

Avoid alcohol, coffee, strong tea, and other stimulants that may aggravate Liver Yang rising and counteract the formula's calming effects. Spicy, hot, and heavily fried foods should be minimized as they generate Heat and may worsen Yang hyperactivity. Favor foods that nourish Blood and Yin: dark leafy greens, black sesame seeds, mulberries, goji berries, red dates, and bone broth. Mild, easily digestible meals support absorption of this rich formula. Since the formula contains heavy mineral and enriching ingredients that can be taxing on digestion, avoid cold or raw foods that may further burden the Spleen and Stomach.

Zhen Zhu Mu Wan originates from 普濟本事方 (Pǔ Jì Běn Shì Fāng) - Formulas of Universal Benefit from My Practice, by Xǔ Shūwēi (许叔微) Sòng dynasty, ~1132 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Zhen Zhu Mu Wan and its clinical use

Original indication from the Pu Ji Ben Shi Fang (普济本事方) by Xu Shuwei:

「治肝经因虚,内受风邪,卧则魂散不守,状若惊悸。」

Translation: "Treats the Liver channel weakened by deficiency, internally receiving Wind pathogen, so that upon lying down the Hun-soul scatters and cannot be kept in place, presenting symptoms resembling fright palpitations."


Formula method from the same source:

「上为细末,炼蜜为丸,如梧桐子大,辰砂为衣。每服四五十丸,金银薄荷汤下,日午、夜卧服。」

Translation: "Grind all ingredients into fine powder, form into honey pills the size of parasol tree seeds, coated with cinnabar. Take 40–50 pills per dose, swallowed with a decoction of honeysuckle and mint, at midday and before sleep."


Classical verse mnemonic (方歌):

「珍珠母丸参地归,犀沉龙齿柏茯神,更加酸枣宁神志,镇心平肝此方推。」

Translation: "Zhen Zhu Mu Wan uses Ginseng, Rehmannia, and Dang Gui; with Rhinoceros horn, Aquilaria, Dragon's teeth, Biota seeds, and Poria with wood. Add Sour Jujube seeds to calm the spirit and mind; this formula is praised for sedating the Heart and calming the Liver."

Historical Context

How Zhen Zhu Mu Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Zhen Zhu Mu Wan originates from the Pu Ji Ben Shi Fang (普济本事方, "Formulas of Universal Benefit from My Practice"), written by the Song Dynasty physician Xu Shuwei (许叔微, c. 1079–1154). Xu Shuwei, also known as "Xu Xueshi" (许学士, "Scholar Xu") because of his civil service career, was one of the most respected clinicians of his era. He lost both parents to illness within 100 days when he was only eleven years old, and this personal tragedy drove him to devote his life to medicine alongside his Confucian studies. His book, published around 1132, recorded formulas he had personally tested in clinical practice along with case records, in the tradition of "recording actual events" (本事). The formula appears in the first chapter on Wind disorders of the Liver and Gallbladder.

The original formula contains Xi Jiao (rhinoceros horn), which was used to clear Heart Heat and calm the Spirit. Due to the international ban on rhinoceros horn trade (CITES), modern versions universally substitute Shui Niu Jiao (water buffalo horn) in much larger doses, or omit it entirely. Similarly, the cinnabar (Zhu Sha) pill coating, while traditional, is increasingly omitted or minimized in modern practice due to mercury toxicity concerns. Some later texts, including the Bao Ying Cuo Yao (保婴撮要) and Zhang Shi Yi Tong (张氏医通), recorded modified versions of this formula under the same name, reflecting its enduring clinical influence across several centuries.