Formula

Xiang Sha Liu Jun Zi Tang

Six-Gentlemen Plus | 香砂六君子汤

Also known as:

Six-Gentlemen Decoction with Costus root and Amomum fruit

Properties

Qi-tonifying formulas · Warm

Key Ingredients

Ren Shen

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula designed to strengthen weak digestion and relieve bloating, nausea, and abdominal discomfort caused by a weak Spleen and Stomach with dampness and stagnation. It builds upon the foundational Si Jun Zi Tang (Four Gentlemen Decoction) by adding herbs that move Qi and resolve phlegm, making it especially suited for people whose digestive weakness is accompanied by a feeling of fullness, poor appetite, and loose stools.

Formula Category

Main Actions

  • Tonifies Qi and Strengthens the Spleen
  • Harmonizes the Stomach
  • Moves Qi and Resolves Stagnation
  • Dries Dampness and Transforms Phlegm
  • Warms the Middle Burner

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Xiang Sha Liu Jun Zi Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Xiang Sha Liu Jun Zi Tang addresses this pattern

When the Spleen is too weak to properly transform food and fluids, unprocessed dampness accumulates and condenses into phlegm. This phlegm-dampness obstructs the middle burner, further impairing the Spleen's already compromised function and creating a vicious cycle. Simultaneously, the weakened Spleen cannot circulate Qi smoothly, so Qi stagnation develops on top of the deficiency. The patient experiences the characteristic combination of deficiency signs (fatigue, poor appetite, pale tongue) alongside excess signs (bloating, fullness, nausea, greasy tongue coating). This formula directly breaks this cycle: Ren Shen, Bai Zhu, Fu Ling, and Zhi Gan Cao rebuild the Spleen's foundational strength; Ban Xia and Chen Pi dissolve the accumulated phlegm-dampness; and Mu Xiang and Sha Ren restore Qi circulation to relieve stagnation. The formula addresses both root (deficiency) and branch (stagnation and phlegm) simultaneously.

A practitioner would look for one or more of these signs

Abdominal Pain

Epigastric and abdominal distension that worsens after eating

Poor Appetite

Reduced appetite or aversion to food

Nausea

Nausea or vomiting of clear or phlegmy fluid

Loose Stools

Loose, unformed stools

Eye Fatigue

Tiredness and lack of physical energy

Abdominal Pain

Dull epigastric or abdominal pain that improves with warmth and pressure

Belching

Frequent belching or acid reflux

How It Addresses the Root Cause

This formula addresses a condition where the Spleen and Stomach have become weak in their core functions of transforming food and drink and transporting nutrients throughout the body. When these organs lose vitality, three problems tend to arise together, each making the others worse.

First, because the Spleen lacks the strength to properly transform fluids, moisture accumulates and thickens into Phlegm and turbid Dampness in the middle part of the torso. Second, without adequate Qi to drive the digestive process, the normal downward movement of the Stomach and the upward lifting function of the Spleen both stall, resulting in Qi stagnation. This stagnation creates a feeling of bloating, fullness, and pressure in the upper abdomen. Third, the combination of weak Qi, stagnant fluids, and blocked movement feeds a self-reinforcing cycle: Dampness further bogs down the Spleen, worsening the deficiency, which produces more Dampness. The classical term for this pattern is "Spleen-Stomach Qi deficiency with Phlegm obstruction and Qi stagnation" (脾胃气虚,痰阻气滞).

Patients caught in this cycle typically experience poor appetite or aversion to food, a sense of fullness or distension in the stomach area even without eating much, nausea or vomiting, loose stools, fatigue, and a pale tongue with a white greasy coating. The formula works by rebuilding the Spleen's Qi while simultaneously clearing away the Phlegm-Dampness and unblocking the stagnant Qi, breaking the vicious cycle from multiple angles at once.

Formula Properties

Temperature

Warm

Taste Profile

Predominantly sweet and acrid (pungent) with mild bitter notes. Sweet from the tonifying herbs to nourish the Spleen, acrid and aromatic from Mu Xiang, Sha Ren, and Chen Pi to move Qi and transform Dampness.

Target Organs
Spleen Stomach Lungs
Channels Entered
Spleen Stomach Lung Large Intestine

Formula Origin

Gǔ Jīn Míng Yī Fāng Lùn (古今名医方论, Ancient and Modern Famous Physicians' Formula Discussions), Volume 1, citing Ke Yunbo (柯韵伯)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Xiang Sha Liu Jun Zi Tang

Detailed information about each herb in Xiang Sha Liu Jun Zi Tang and their roles

Kings
Deputies
Assistants
Envoys
Ren Shen
Ren Shen

Ginseng root

Dosage: 3 - 9g

Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys
Parts Used Root (根 gēn)
Role in Xiang Sha Liu Jun Zi Tang

The chief herb for powerfully tonifying the Qi of the Spleen and Stomach, restoring the fundamental digestive capacity that drives the entire formula's therapeutic strategy. As the core of the underlying Si Jun Zi Tang structure, it addresses the root deficiency.

Bai Zhu
Bai Zhu

White Atractylodes rhizome

Dosage: 6 - 12g

Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Xiang Sha Liu Jun Zi Tang

Strengthens the Spleen and dries dampness, directly supporting Ren Shen in tonifying the middle burner while addressing the accumulation of dampness that impairs digestive function.

Fu Ling
Fu Ling

Poria

Dosage: 6 - 12g

Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys
Parts Used Fungus / Mushroom (菌类 jūn lèi)
Role in Xiang Sha Liu Jun Zi Tang

Promotes water metabolism and leaches out dampness through the urinary pathway, while gently strengthening the Spleen. Works alongside Bai Zhu to address the dampness component from a complementary angle.

Ban Xia
Ban Xia

Pinellia rhizome

Dosage: 3 - 9g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Xiang Sha Liu Jun Zi Tang

Dries dampness and transforms phlegm, while harmonizing the Stomach and directing rebellious Qi downward to stop nausea and vomiting. A key herb for resolving the phlegm-dampness that accumulates when the Spleen fails to transform fluids.

Chen Pi
Chen Pi

Tangerine peel

Dosage: 3 - 6g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Spleen
Parts Used Peel / Rind (皮 pí / 果皮 guǒ pí)
Role in Xiang Sha Liu Jun Zi Tang

Regulates Qi flow and dries dampness, helping to prevent the tonifying herbs from creating stagnation. Its aromatic nature awakens the Spleen and its Qi-moving action relieves the chest and epigastric fullness.

Mu Xiang
Mu Xiang

Costus root

Dosage: 2 - 6g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, San Jiao (Triple Burner), Gallbladder
Parts Used Root (根 gēn)
Role in Xiang Sha Liu Jun Zi Tang

Strongly promotes the movement of Qi through the three burners, relieving pain and distension in the epigastrium and abdomen. Its warm, acrid nature breaks through Qi stagnation that accumulates when the Spleen is too weak to circulate Qi properly.

Sha Ren
Sha Ren

Amomum fruit

Dosage: 2 - 6g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Spleen, Stomach, Kidneys
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Xiang Sha Liu Jun Zi Tang

Aromatically transforms dampness and warms the middle burner, while promoting Qi circulation between the Spleen and Kidney. Its fragrant warmth awakens a sluggish Spleen and stops vomiting and diarrhea.

Gan Cao
Gan Cao

Licorice root

Dosage: 2 - 3g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Xiang Sha Liu Jun Zi Tang

Tonifies the Spleen Qi in its own right while harmonizing all the other herbs in the formula. Its sweet flavor supports the middle burner and moderates the drying and moving properties of the other ingredients.

Modern Research (3 studies)

  • Efficacy and safety of Xiangsha Liujunzi granules for functional dyspepsia: A multi-center randomized double-blind placebo-controlled clinical study (RCT, 2017)
  • Chinese Herbal Medicine Liu Jun Zi Tang and Xiang Sha Liu Jun Zi Tang for Functional Dyspepsia: Meta-Analysis of Randomized Controlled Trials (Meta-analysis, 2012)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

30 minutes before meals, twice daily (morning and evening), taken warm.

Typical Duration

Typically prescribed for 2-4 weeks for acute digestive complaints, or 4-8 weeks for chronic conditions such as chronic gastritis or functional dyspepsia, with periodic reassessment by a practitioner.

Dietary Advice

Avoid cold and raw foods (salads, iced drinks, raw fruit in excess, sushi), as these burden an already weakened Spleen and Stomach. Reduce greasy, fried, and heavily rich foods, which generate more Dampness and Phlegm. Limit dairy products, sugar, and excessively sweet foods, which also tend to produce Dampness. Favor warm, cooked, easily digestible meals such as congee (rice porridge), soups, steamed vegetables, and well-cooked grains. Foods that gently support Spleen function are helpful: yam (shan yao), cooked lotus seed, millet, ginger, and jujube dates. Eat regular meals at consistent times rather than large irregular meals, and avoid overeating, which strains the already deficient digestive system.

Modern Usage

This formula is used to treat conditions caused by Spleen and Stomach Qi Deficiency, with Phlegm obstruction and Qi Stagnation. It is indicated by symptoms such as abdominal distension and pain, vomiting, a feeling of fullness, loss of appetite, and a pale tongue with a white, greasy coating.

Clinically, it can be applied in cases of gastric ulcers, duodenal ulcers, chronic gastritis, gastroptosis, gastrointestinal dysfunction, bronchiectasis, chronic atrophic gastritis, diabetes, autonomic nervous system disorders affecting the intestines, and renal anemia (with modifications to the formula), where these conditions are associated with Spleen and Stomach Qi Deficiency, Phlegm obstruction, and Qi Stagnation.

Special Populations

Pregnancy

Use with caution during pregnancy. Ban Xia (Pinellia) is traditionally classified as a pregnancy-cautioned herb due to its potential to cause uterine stimulation, though the processed forms (Fa Ban Xia, Jiang Ban Xia) used in this formula are significantly milder than the raw form. Mu Xiang and Sha Ren strongly move Qi, which warrants additional care. Sha Ren, interestingly, is used in some classical formulas to calm a restless fetus in Spleen deficiency, so it is not itself contraindicated. Overall, the formula is not absolutely contraindicated but should only be prescribed by a qualified practitioner who can assess the specific clinical situation. Avoid in early pregnancy without professional guidance.

Breastfeeding

Generally considered compatible with breastfeeding when used appropriately and under professional guidance. The herbs in this formula are mostly gentle tonifying and Qi-moving substances without known toxicity concerns regarding transfer through breast milk. Ren Shen (Ginseng) may mildly stimulate and could theoretically affect a sensitive infant, so practitioners sometimes substitute Dang Shen (Codonopsis) as a gentler alternative. Gan Cao (Licorice) in moderate doses is not expected to cause issues but should not be used in excessive amounts during lactation. No specific adverse effects on milk production or infant health have been reported in the classical literature. Consult a qualified practitioner before use.

Pediatric Use

This formula can be used in children, particularly for pediatric digestive complaints such as poor appetite, chronic loose stools, and failure to thrive due to Spleen Qi deficiency. Dosage should be reduced proportionally based on age and body weight: roughly one-quarter to one-third of the adult dose for children under 6, and one-half for children aged 6-12. Ren Shen (Ginseng) is sometimes replaced with the milder Dang Shen (Codonopsis) in pediatric prescriptions. The formula should be prescribed by a qualified practitioner who can properly differentiate the pattern. Avoid prolonged use without reassessment, as children's constitutions change rapidly.

Drug Interactions

Gan Cao (Licorice): The glycyrrhizin in Gan Cao may cause potassium depletion and sodium/water retention. It can interact with corticosteroids (additive potassium loss), digoxin and other cardiac glycosides (hypokalemia increases toxicity risk), diuretics especially loop and thiazide types (compounded electrolyte imbalance), and antihypertensive medications (may counteract blood pressure lowering through fluid retention).

Ren Shen (Ginseng): May interact with warfarin and other anticoagulants (potential alteration of INR), hypoglycemic agents including insulin (additive blood sugar lowering), and MAO inhibitors (risk of overstimulation). Ginseng may also reduce the effectiveness of immunosuppressants due to its immune-modulating properties.

Ban Xia (Pinellia): The processed form used in this formula is low in toxicity, but it is traditionally considered incompatible with Wu Tou (Aconitum) preparations. No major documented pharmaceutical drug interactions, but the herb's gastrointestinal effects may theoretically alter absorption rates of orally administered drugs.

General note: As a formula that affects gastrointestinal motility and gastric function, it may alter the absorption rate or bioavailability of concurrently taken oral medications. It is advisable to separate the timing of this formula from pharmaceutical drugs by at least 1-2 hours.

Contraindications

Avoid

Yin deficiency with Heat signs (dry mouth, night sweats, red tongue with little coating). This formula is warm and drying in nature, which would further deplete Yin fluids and aggravate Heat.

Avoid

Stomach Heat or Damp-Heat patterns (burning epigastric pain, acid reflux with bitter taste, yellow greasy tongue coating). The warming herbs would intensify the Heat.

Caution

Constipation due to dryness or fluid depletion. The drying nature of Ban Xia, Bai Zhu, and Chen Pi may worsen dry constipation.

Caution

Acute exterior conditions (common cold, influenza). Tonifying the interior while a pathogen occupies the exterior may trap the pathogen inside the body.

Caution

Patients with active bleeding or those on anticoagulant therapy should use caution, as Mu Xiang and Sha Ren strongly move Qi and could theoretically influence circulation.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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