Yi Gong San

Extraordinary Merit Powder · 异功散

Also known as: Wu Wei Yi Gong San (五味异功散, Five-Ingredient Extraordinary Merit Powder)

A gentle classical formula for strengthening weak digestion, originally created by the Song dynasty pediatrician Qian Yi. It builds on the foundational Four Gentlemen Decoction by adding tangerine peel to relieve bloating and help the body absorb the tonic herbs more effectively. Commonly used for poor appetite, bloating after eating, loose stools, and general digestive weakness in both children and adults.

Origin Xiao Er Yao Zheng Zhi Jue (《小儿药证直诀》, Key to Therapeutics of Children's Diseases), Volume 3 — Northern Song dynasty (北宋), c. 1119 CE
Composition 5 herbs
Ren Shen
King
Ren Shen
Bai Zhu
Deputy
Bai Zhu
Fu Ling
Assistant
Fu Ling
Chen Pi
Assistant
Chen Pi
Gan Cao
Envoy
Gan Cao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Yi Gong San is designed to correct these specific patterns.

Why Yi Gong San addresses this pattern

This formula directly targets Spleen Qi deficiency by combining the three core Qi-tonifying herbs (Ren Shen, Bai Zhu, Zhi Gan Cao) with Dampness-resolving Fu Ling. The addition of Chen Pi makes it particularly well-suited for Spleen Qi deficiency cases where stagnation has developed as a secondary consequence of the weakness. Patients with pure Spleen Qi deficiency without stagnation may do well with Si Jun Zi Tang alone, but when there is also chest stuffiness, abdominal distension after eating, or nausea, this formula's Qi-regulating component makes it the better choice.

A practitioner would look for one or more of these signs

Poor Appetite

Reduced desire to eat due to weakened Spleen transporting function

Loose Stools

Soft, unformed stools from impaired fluid transformation

Abdominal Bloating

Distension and fullness in the upper abdomen, especially after eating

Fatigue

Tiredness and lack of vitality from insufficient Qi production

Nausea

Mild nausea or tendency to vomit, especially in children

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Yi Gong San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Spleen Qi Deficiency with Qi Stagnation

TCM Interpretation

In TCM, poor appetite in children is most commonly understood as a Spleen and Stomach weakness. Children's digestive systems are considered inherently immature and delicate. When the Spleen Qi becomes deficient through irregular feeding, illness, or constitutional weakness, its ability to transform food weakens. The child loses interest in eating because the digestive system simply cannot process what it receives. The resulting Qi stagnation in the Middle Burner creates a vicious cycle: poor digestion leads to less nourishment, which further weakens the Spleen.

Why Yi Gong San Helps

Yi Gong San addresses pediatric poor appetite from both angles of the problem. Ren Shen and Bai Zhu rebuild the Spleen's digestive capacity, while Chen Pi gently moves the stagnant Qi that makes the child feel full and uninterested in food. Fu Ling assists by draining accumulated Dampness, and Zhi Gan Cao harmonizes the formula. The gentle, balanced nature of the formula makes it particularly suitable for children's delicate constitutions. Clinical studies have shown high effectiveness rates when using modified Yi Gong San for pediatric anorexia.

Also commonly used for

Indigestion

Functional dyspepsia with Spleen Qi deficiency

Nausea

Nausea and vomiting due to Stomach weakness

Irritable Bowel Syndrome

Spleen-deficient type with bloating and loose stools

Recurrent Respiratory Infections

In children, where Spleen deficiency leads to weak defensive Qi

Allergic Rhinitis

Remission phase in children with Lung-Spleen Qi deficiency

Failure To Thrive

Pediatric malnutrition and wasting (gan syndrome)

What This Formula Does

Every TCM formula has a specific set of actions — here's what Yi Gong San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Yi Gong San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Yi Gong San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Yi Gong San works at the root level.

This formula addresses a situation where the Spleen and Stomach have become weakened and can no longer properly transform food and fluids. In TCM, the Spleen is the central organ of digestion, responsible for extracting nourishment from food and transporting it throughout the body. When Spleen Qi becomes deficient, this transforming and transporting function falters. Food sits in the digestive tract without being properly processed, leading to reduced appetite, bloating, and loose stools.

The crucial twist in this pattern is that the Qi deficiency itself creates a secondary problem: Qi stagnation. When the Spleen is too weak to move things along, Qi pools and stagnates in the Middle Burner (the digestive region). This produces a feeling of fullness and stuffiness in the chest and upper abdomen, belching, or nausea. It also creates a therapeutic dilemma: the patient needs tonification, but pure tonifying herbs can make the stagnation worse, causing even more bloating. This is the classic "deficiency that cannot accept supplementation" (虚不受补) scenario. The formula resolves this by combining Qi tonification with gentle Qi regulation, so that the supplementing action can be absorbed without creating further stagnation.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly sweet and mild with a slight pungent note — sweet to tonify Spleen Qi, bland to drain Dampness, and pungent from Chen Pi to move Qi and prevent stagnation.

Channels Entered

Ingredients

5 herbs

The herbs that make up Yi Gong San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Ren Shen

Ren Shen

Ginseng root

Dosage 6 - 9g
Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys

Role in Yi Gong San

Powerfully tonifies the Spleen and Stomach Qi, serving as the primary force to restore the weakened digestive system and address the root deficiency.
Deputy — Assists and enhances the King
Bai Zhu

Bai Zhu

White Atractylodes rhizome

Dosage 6 - 9g
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach

Role in Yi Gong San

Strengthens the Spleen and dries Dampness, reinforcing Ren Shen's Qi-tonifying action while addressing the accumulation of Dampness that results from Spleen weakness.
Assistants — Supports or moderates other herbs
Fu Ling

Fu Ling

Poria

Dosage 6 - 9g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Yi Gong San

Promotes urination and leaches out Dampness while supporting the Spleen's transporting function. Works alongside Bai Zhu to address fluid accumulation from Spleen deficiency.
Chen Pi

Chen Pi

Tangerine peel

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Spleen

Role in Yi Gong San

The key addition that distinguishes this formula from Si Jun Zi Tang. Regulates Qi flow and resolves stagnation in the Middle Burner, preventing the tonifying herbs from causing bloating. This ensures the formula supplements without creating stagnation.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 6 - 9g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Yi Gong San

Tonifies Qi and harmonizes the Middle Burner while moderating and coordinating the actions of all the other herbs in the formula.

Why This Combination Works

How the herbs in Yi Gong San complement each other

Overall strategy

The formula builds on the foundational Si Jun Zi Tang (Four Gentlemen Decoction) structure for Spleen Qi deficiency, adding a single Qi-regulating herb to address the secondary stagnation that arises when the weakened Spleen cannot move Qi properly. The result is a formula that "supplements without creating stagnation" (补而不滞).

King herbs

Ren Shen (Ginseng) is the King herb. It powerfully tonifies the original Qi and strengthens the Spleen and Stomach, directly addressing the root cause of the pattern. Its sweet, slightly warm nature makes it ideal for nourishing the digestive organs without being overly drying or heating.

Deputy herbs

Bai Zhu (White Atractylodes) serves as Deputy, reinforcing Ren Shen's Spleen-strengthening action from a complementary angle. While Ren Shen directly replenishes Qi, Bai Zhu focuses on drying the Dampness that inevitably accumulates when the Spleen is weak, restoring the organ's ability to transform and transport fluids.

Assistant herbs

Fu Ling (Poria) is a reinforcing Assistant that supports Bai Zhu by promoting urination and draining Dampness downward through the water pathways, while also gently strengthening the Spleen. Together, Fu Ling and Bai Zhu comprehensively address fluid metabolism problems caused by Spleen weakness.

Chen Pi (Tangerine Peel) is the defining Assistant of this formula, acting as both a reinforcing and restraining agent. Its acrid, warm nature moves Qi and breaks up stagnation in the Middle Burner, preventing the heavy tonifying herbs from causing bloating. It also awakens the Spleen and assists its transporting function.

Envoy herbs

Zhi Gan Cao (Honey-prepared Licorice) harmonizes all the ingredients, tonifies the Middle Burner Qi, and ensures the formula works as a balanced whole. The ginger and dates used in the decoction further warm the Stomach and support digestion.

Notable synergies

The pairing of Ren Shen with Chen Pi is the intellectual core of this formula. Ren Shen powerfully supplements but can cause stagnation in a weak digestive system, while Chen Pi moves Qi and prevents this problem. Together they achieve supplementation that flows freely. The Bai Zhu and Fu Ling pairing is a classical combination for addressing Spleen-related Dampness from two complementary directions: drying (Bai Zhu) and draining (Fu Ling).

How to Prepare

Traditional preparation instructions for Yi Gong San

Traditionally, all five herbs are ground into a fine powder (细末). For each dose, take approximately 6g of the powder, add 150ml of water along with 5 slices of fresh ginger (Sheng Jiang) and 2 Chinese dates (Da Zao), then decoct together until roughly 100ml of liquid remains. Strain and drink warm before meals.

In modern practice, the herbs are more commonly used as whole pieces rather than powder. Decoct the five herbs together with 2-3 slices of ginger and 2 dates in approximately 400ml of water. Bring to a boil, then simmer on low heat for 20-30 minutes until about 200ml remains. Strain and take warm in two divided doses, before meals.

Common Modifications

How practitioners adapt Yi Gong San for specific situations

Added
6-9g, digests meat and greasy food accumulation
Shen Qu

6-9g, promotes digestion of grain-based foods

Gu Ya

6-9g, gently assists grain digestion and awakens the Spleen

When Spleen Qi deficiency leads to food stagnation with sour belching or undigested food in the stool, these digestive herbs help break down the accumulated food while the base formula restores Spleen function.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Yi Gong San should not be used or requires extra caution

Avoid

Patterns of excess Heat or Damp-Heat in the Spleen and Stomach. Because this formula is warm in nature and tonifying, it can aggravate conditions with Heat signs such as bitter taste, dry mouth, yellow tongue coating, or active inflammation of the gastrointestinal tract (e.g. acute gastritis, peptic ulcer in active phase).

Caution

Yin deficiency with Heat signs. In people with significant Yin deficiency showing signs like night sweats, five-palm heat, and a red tongue with little coating, the warming and Qi-tonifying nature of this formula may further deplete Yin fluids.

Caution

Food stagnation or excess conditions causing abdominal distension. When poor appetite or bloating is caused by food accumulation or excess Dampness rather than Spleen Qi deficiency, tonifying formulas like this one can worsen the stagnation.

Avoid

Known allergy or hypersensitivity to any ingredient in the formula, especially Ren Shen (Ginseng) or Gan Cao (Licorice). Discontinue immediately if allergic reactions such as skin rash or itching occur.

Caution

Severe liver or kidney impairment. Gan Cao (Licorice) can cause fluid retention and should be used cautiously in patients with compromised organ function. Dose adjustment and medical supervision are advised.

Caution

Hypertension or edema. Both Ren Shen (Ginseng) and Gan Cao (Licorice) may raise blood pressure or promote fluid retention when used in higher doses or over prolonged periods. Use with caution and monitoring.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe for short-term use during pregnancy under practitioner guidance, as none of the five herbs (Ren Shen, Bai Zhu, Fu Ling, Chen Pi, Zhi Gan Cao) are classified as abortifacient or strongly contraindicated in pregnancy. However, Ren Shen (Ginseng) should be used cautiously in pregnancy due to its stimulating properties, and Gan Cao (Licorice) in higher doses or prolonged use may contribute to fluid retention and elevated blood pressure, which are particular concerns during pregnancy. Pregnant individuals should only take this formula under the supervision of a qualified practitioner who can adjust the dosage appropriately.

Breastfeeding

Yi Gong San is traditionally considered compatible with breastfeeding and has historically been used in postpartum women to strengthen Spleen Qi and support digestion. The herbs in this formula are mild and food-grade in nature. Ren Shen (Ginseng) may theoretically pass small amounts of ginsenosides into breast milk, though no significant adverse effects on nursing infants have been documented at standard doses. Gan Cao (Licorice) should not be used in excessive doses during breastfeeding due to its potential for fluid retention. Overall, use at standard doses under practitioner guidance is considered acceptable during breastfeeding.

Children

Yi Gong San was originally designed as a paediatric formula and is considered one of the most important classical prescriptions for children with Spleen Qi deficiency. It is suitable for infants and children of all ages with appropriate dose adjustment. According to classical and modern dosage research, the paediatric dose of each herb (Ren Shen, Fu Ling, Bai Zhu, Chen Pi, Gan Cao) is approximately 1.4 to 1.7 grams per serving when prepared as a fine powder decoction with fresh ginger and dates. For older children and adolescents, doses can be gradually increased toward adult levels. The original text instructs practitioners to adjust the amount given based on the child's size and condition. Modern clinical use typically involves 2 to 4 weeks of treatment for conditions like paediatric anorexia and chronic diarrhoea, with reassessment by a practitioner. Children should always take this formula under qualified medical supervision.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Yi Gong San

Gan Cao (Licorice, 甘草): The glycyrrhizin in Licorice has well-documented interactions with several drug classes. It can cause potassium depletion and sodium retention, which may worsen the effects of potassium-wasting diuretics (e.g. furosemide, hydrochlorothiazide) and increase the risk of toxicity with cardiac glycosides such as digoxin. Long-term or high-dose use alongside corticosteroids may amplify mineralocorticoid side effects. Licorice may also counteract the effects of antihypertensive medications by promoting fluid retention and raising blood pressure.

Ren Shen (Ginseng, 人参): Ginseng contains ginsenosides that may induce liver cytochrome P450 enzymes, potentially reducing the effectiveness of warfarin and other anticoagulants. It may also interact with insulin or oral hypoglycaemic agents by affecting blood sugar levels. Concurrent use with MAO inhibitors or stimulant medications should be approached cautiously due to possible additive stimulatory effects.

Individuals taking any prescription medications, particularly anticoagulants, antihypertensives, diuretics, or cardiac glycosides, should consult both their prescribing physician and a qualified TCM practitioner before using this formula.

Usage Guidance

Practical advice for getting the most out of Yi Gong San

Best time to take

30 minutes before meals on an empty stomach, taken warm (饭前温服), as specified in the classical source.

Typical duration

Usually prescribed for 2–4 weeks, with reassessment by a practitioner; may be extended for chronic Spleen deficiency conditions.

Dietary advice

Avoid cold, raw, and chilled foods and beverages (such as ice cream, cold salads, chilled drinks, and raw fruit in excess) while taking this formula, as these can further burden the Spleen and counteract the warming, tonifying effects of the herbs. Avoid greasy, heavy, and overly rich foods (deep-fried dishes, fatty meats, excessive dairy) which can create Dampness and stagnation, hindering the formula's Qi-moving action. Favour warm, easily digestible, and nourishing foods such as congee (rice porridge), well-cooked soups, steamed vegetables, millet, yam, jujube dates, and lean proteins. Eating regular, moderate-sized meals at consistent times supports the Spleen and Stomach recovery that this formula promotes.

Yi Gong San originates from Xiao Er Yao Zheng Zhi Jue (《小儿药证直诀》, Key to Therapeutics of Children's Diseases), Volume 3 Northern Song dynasty (北宋), c. 1119 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Yi Gong San and its clinical use

《小儿药证直诀》卷下 (Xiao Er Yao Zheng Zhi Jue, Volume 3) — Qian Yi (钱乙), Northern Song dynasty:

「温中和气,治吐泻,不思乳食。凡小儿虚冷病,先与数服,以助其气。」

Translation: "Warms the Middle and harmonises Qi. Treats vomiting and diarrhoea, and loss of desire for breast milk or food. For all children's diseases of deficiency-Cold, give several doses first to support their Qi."


《保婴撮要》(Bao Ying Cuo Yao) — Xue Kai (薛铠), Ming dynasty:

「温补脾胃,调补元气。」

Translation: "Warmly tonifies the Spleen and Stomach, regulates and supplements the original Qi."

Historical Context

How Yi Gong San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Yi Gong San was created by Qian Yi (钱乙, c. 1032–1113), the most celebrated paediatric physician in Chinese medical history, often called the "Sage of Paediatrics" (儿科之圣). The formula appears in his masterwork Xiao Er Yao Zheng Zhi Jue (《小儿药证直诀》), the earliest surviving dedicated paediatric text in Chinese medicine, which was compiled and edited by his student Yan Xiaozhong (阎孝忠) around 1119 CE.

The formula is a modification of the classic Si Jun Zi Tang (Four Gentlemen Decoction) with the addition of Chen Pi (Tangerine Peel). Qian Yi's insight was that children's delicate Spleens are easily overwhelmed by pure tonification, so adding Chen Pi's gentle Qi-moving action prevents the tonifying herbs from creating stagnation — achieving what later commentators praised as "supplementing without causing stagnation" (补而不滞). Yi Gong San is one of Qian Yi's three famous Spleen-regulating formulas alongside Yi Huang San (益黄散) and Bai Zhu San (白术散), each addressing different aspects of paediatric digestive weakness. In 2022, China's National Administration of Traditional Chinese Medicine included Yi Gong San in the Catalogue of Ancient Classical Formulas (Second Batch, Paediatric Section) as formula No. 3, reflecting its enduring clinical importance and opening a pathway for standardised modern development.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Yi Gong San

1

Effect of Yi Gong San Decoction on Iron Homeostasis in a Mouse Model of Acute Inflammation (Preclinical, 2016)

Zheng Q, Guan Y, Xia L, Wang Z, Jiang Y, Zhang X, Wang J, Wang G, Pu Y, Xia J, Luo M. Evidence-Based Complementary and Alternative Medicine, 2016, 2016:2696480.

This animal study investigated how Yi Gong San affects iron metabolism during acute inflammation in mice. The researchers found that the formula helped regulate iron balance by reducing levels of hepcidin (a key iron-regulating hormone) through the IL-6/STAT3 and BMP/SMAD pathways. This provides a potential mechanism for how the formula may help with anaemia associated with chronic inflammation, a condition often seen in Spleen Qi deficiency patterns.

DOI
2

Mechanism of Yigong San Anti-Gastric Cancer and Immune Regulation (Network Pharmacology, 2024)

Lu DD, Yuan L, Wang ZZ, Zhao JJ, Du YH, Ning N, Chen GQ, Huang SC, Yang Y, Zhang Z, Nan Y. World Journal of Gastrointestinal Oncology, 2024, 16(5).

This network pharmacology study explored the potential mechanisms by which Yi Gong San may exert anti-gastric cancer and immune-regulating effects. Through computational analysis and molecular docking, the researchers found that the formula's active components could effectively bind to therapeutic targets involved in cancer progression and immune regulation, suggesting its potential as an adjunctive treatment for gastric cancer.

PubMed
3

Yi Gong San Inhibits Tumor Immune Escape by Sensitizing Colorectal Cancer Stem Cells via the NF-κB Pathway (Preclinical, 2025)

Shen P, Wu S, Chen Y, Feng G, Guo X, Chen Y, Wang Z, Shen Y, Wang H, Li K. Hereditas, 2025, 162(1):64.

Using network pharmacology and laboratory experiments, this study found that Yi Gong San and its active component Gomisin B may inhibit colorectal cancer progression through the TLR4/NF-κB signalling pathway. The combined treatment of Yi Gong San with cisplatin enhanced anti-tumour effects, increased sensitivity to chemotherapy drugs, and reduced immune escape of cancer cells. While promising, these are preclinical findings requiring further clinical validation.

DOI
4

Pharmacokinetics and Tissue Distribution of Yigong San in Rats (Preclinical, 2024)

Journal of Ethnopharmacology, 2024, 332.

This pharmacokinetic study identified eight key active compounds of Yi Gong San (including liquiritin, hesperidin, ginsenosides Rb1/Re/Rg1, and atractylenolides I and II) in rat plasma and tissues after oral administration. The compounds were widely distributed across various tissues, providing foundational data for understanding how the formula works in the body and supporting its development as a standardised modern medicine.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.