Formula Pill (Wan)

Si Hai Shu Yu Wan

Four Seas Soothe Depression Pill · 四海舒郁丸

Also known as: Si Hai Shu Yu Tang (decoction form), Four Seas Dispel Stagnation Pill

A classical formula designed to address neck swelling and thyroid nodules caused by emotional stress and Phlegm accumulation. It combines multiple sea-derived substances that soften hardness and dissolve nodules with Qi-moving herbs that relieve stagnation. Widely used in modern practice for thyroid conditions including goiter and benign thyroid nodules.

Origin Yáng Yī Dà Quán (疡医大全, Complete Collection of Sore Medicine), Volume 18, by Gù Shìchéng (顾世澄) — Qīng dynasty, 1760 CE
Composition 7 herbs
Hai Zao
King
Hai Zao
Kun Bu
King
Kun Bu
Hai Zao
Deputy
Hai Zao
Hai Piao Shao
Deputy
Hai Piao Shao
Mu Xiang
Assistant
Mu Xiang
Chen Pi
Assistant
Chen Pi
Ha
Assistant
Hai Ge Fen (海蛤粉, Clam Shell Powder)
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Si Hai Shu Yu Wan is designed to correct these specific patterns.

Why Si Hai Shu Yu Wan addresses this pattern

This is the primary pattern addressed by Si Hai Shu Yu Wan. When emotional stress, frustration, or prolonged worry causes the Liver Qi to become stagnant, the Qi fails to move fluids properly. Over time, this stagnation impairs the Spleen's ability to transform and transport fluids, leading to the accumulation of Phlegm. This Phlegm then follows the stagnant Qi upward and congeals in the throat area, forming soft swellings that characteristically grow and shrink with the person's emotional state. The formula's sea-product herbs (Hai Zao, Kun Bu, Hai Dai, Hai Piao Xiao, Hai Ge Fen) directly dissolve and soften the congealed Phlegm, while Qing Mu Xiang and Chen Pi restore the smooth flow of Qi to address the underlying mechanism.

A practitioner would look for one or more of these signs

Goiter

Soft, diffuse swelling of the front of the neck

Nodules

Lumps in the throat area that may fluctuate in size with emotions

Feeling Of Chest Oppression

Feeling of tightness or fullness in the chest

Sighing

Frequent sighing as an unconscious attempt to relieve Qi stagnation

Difficulty In Moving

Sensation of obstruction in the throat, difficulty swallowing in severe cases

Irritability

Mood fluctuations, especially frustration and irritability

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Si Hai Shu Yu Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, thyroid nodules are understood as a form of 'ying' (瘿, goiter disease). The throat sits along the pathway of the Liver channel, making it particularly vulnerable when Liver Qi becomes stagnant. Emotional stress, frustration, or suppressed anger cause the Liver's free-flowing function to stall. When Qi stagnates, it fails to move body fluids properly, leading to Phlegm accumulation. This Phlegm, guided by the stagnant Qi, lodges in the throat and gradually solidifies into palpable nodules. A hallmark sign in TCM is that these nodules change in size with the patient's emotional state, growing larger during periods of anger or stress and shrinking when calm.

Why Si Hai Shu Yu Wan Helps

Si Hai Shu Yu Wan directly targets both aspects of the pathomechanism. The sea-derived herbs (Hai Zao, Kun Bu, Hai Dai, Hai Piao Xiao, Hai Ge Fen) are salty in nature, which in TCM theory gives them a natural ability to soften hardness and dissolve Phlegm accumulations. Modern research has noted that these seaweeds are rich in iodine, which may contribute to their effects on thyroid tissue. Meanwhile, Qing Mu Xiang and Chen Pi restore the smooth flow of Qi, addressing the emotional stagnation at the root of the problem. Clinical studies have shown significant reduction in nodule size after three months of treatment with this formula.

Also commonly used for

Thyroid Adenoma

Thyroid adenoma treated with modifications

Scrofula

Cervical lymph node swelling (瘰疬)

Hyperthyroidism

Early-stage hyperthyroidism with Phlegm-Qi stagnation presentation

Lipoma

Soft tissue masses from Phlegm accumulation

What This Formula Does

Every TCM formula has a specific set of actions — here's what Si Hai Shu Yu Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Si Hai Shu Yu Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Si Hai Shu Yu Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Si Hai Shu Yu Wan works at the root level.

Si Hai Shu Yu Wan addresses a pattern where emotional stress and pent-up frustration cause the Liver's Qi-moving function to stall. When the Liver fails to maintain the smooth flow of Qi throughout the body, two things go wrong at once. First, the stagnant Qi itself pools in the throat and neck area, forming a soft, diffuse swelling. Second, because Qi is what drives the movement of body fluids, stagnant Qi allows fluids to collect and thicken into Phlegm. This Phlegm then binds together with the stuck Qi and congeals in the neck, producing the characteristic goiter (called "Qi ying" 气瘿 in TCM) that classically fluctuates in size with the patient's emotional state, growing larger when the person is angry or upset and shrinking when they are calm.

The Liver's stagnation also affects the Spleen. Because the Liver "controls" the Spleen through the Wood-Earth relationship, Liver depression readily impairs the Spleen's ability to transform and transport fluids. This makes the Phlegm problem worse, creating a self-reinforcing cycle: Liver stagnation produces Phlegm, and the Phlegm further obstructs Qi flow. Over time the mass consolidates in the neck, potentially causing a sensation of obstruction in the throat or difficulty swallowing. The formula intervenes by simultaneously freeing the trapped Qi and dissolving the Phlegm accumulation, breaking this cycle at both points.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly salty and acrid, with a bitter undertone. The salty taste from the four marine herbs softens hardness and dissolves Phlegm, while the acrid quality of Qing Mu Xiang and Chen Pi moves stagnant Qi.

Channels Entered

Ingredients

7 herbs

The herbs that make up Si Hai Shu Yu Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Kings — Main ingredient driving the formula
Hai Zao

Hai Zao

Sargassum

Dosage 60g
Temperature Cold
Taste Bitter, Salty
Organ Affinity Kidneys, Liver, Stomach
Preparation Rinse with boiling water to remove salt before use

Role in Si Hai Shu Yu Wan

Salty and cold, enters the Liver, Stomach, and Kidney channels. Clears Phlegm-Heat, softens hardness, and dissipates nodules. Used at the highest dosage in the formula, it directly targets the core pathology of Phlegm congealing in the neck to form goiter.
Kun Bu

Kun Bu

Kombu

Dosage 60g
Temperature Cold
Taste Salty
Organ Affinity Kidneys, Liver, Stomach
Preparation Rinse with boiling water to remove salt before use

Role in Si Hai Shu Yu Wan

Salty and cold, enters the Liver, Stomach, and Kidney channels. Works alongside Hai Zao to soften hardness and dissolve Phlegm nodules. Together they form the primary assault on the Phlegm-mass in the neck.
Deputies — Assists and enhances the King
Hai Zao

Hai Zao

Sargassum

Dosage 60g
Temperature Cold
Taste Bitter, Salty
Organ Affinity Kidneys, Liver, Stomach
Preparation Rinse with boiling water to remove salt before use

Role in Si Hai Shu Yu Wan

Salty and cold, softens hardness and disperses nodules. Reinforces the Phlegm-resolving and nodule-dissipating actions of the King herbs, strengthening the formula's ability to break down accumulations in the throat area.
Hai Piao Shao

Hai Piao Shao

Cuttlebones

Dosage 60g
Temperature Warm
Taste Pungent, Salty
Organ Affinity Spleen, Kidneys
Preparation Rinse with boiling water to remove salt before use

Role in Si Hai Shu Yu Wan

Salty and astringent, slightly warm. Unlike the other sea products which primarily dissolve Phlegm, Hai Piao Xiao has a Blood-activating quality that helps break down established masses and resolve stasis contributing to goiter formation.
Assistants — Supports or moderates other herbs
Mu Xiang

Mu Xiang

Costus roots

Dosage 15g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Gallbladder, Large Intestine, Liver, Lungs, Spleen, Stomach

Role in Si Hai Shu Yu Wan

Acrid and bitter, moves Qi and resolves stagnation. Addresses the root cause of the condition by coursing the Liver Qi, relieving the emotional constraint and Qi stagnation that drives Phlegm production and accumulation in the first place.
Chen Pi

Chen Pi

Tangerine peel

Dosage 9g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Lungs, Spleen

Role in Si Hai Shu Yu Wan

Acrid, bitter, and warm. Regulates Qi, dries Dampness, and transforms Phlegm. Supports the Spleen's role in Phlegm production and works with Qing Mu Xiang to restore normal Qi movement, while also helping the sea products break down Phlegm accumulations.
Ha

Hai Ge Fen (海蛤粉, Clam Shell Powder)

Dosage 9g

Role in Si Hai Shu Yu Wan

Salty and cold. Clears Lung Heat, transforms Phlegm, and softens hardness. Bridges the Phlegm-resolving sea products and the Qi-regulating herbs, adding a Heat-clearing dimension that addresses any Heat component within the Phlegm nodules.

Why This Combination Works

How the herbs in Si Hai Shu Yu Wan complement each other

Overall strategy

This formula addresses goiter and neck nodules caused by Liver Qi stagnation generating Phlegm that congeals in the throat. The strategy combines powerful sea-derived, salty-natured substances to soften and dissolve the Phlegm mass (treating the manifestation) with Qi-moving herbs to relieve the underlying stagnation (treating the root).

King herbs

Hai Zao and Kun Bu are both salty and cold, with strong abilities to soften hardness, dissolve Phlegm, and dissipate nodules. Used at the highest dosage (60g each), they form the formula's main therapeutic force, directly targeting the Phlegm-mass congealed in the neck. The salty flavor in TCM theory has a natural affinity for softening hard accumulations, making these marine herbs ideal for addressing goiter.

Deputy herbs

Hai Dai reinforces the King herbs' Phlegm-dissolving and nodule-softening actions, adding strength to the formula's core mechanism. Hai Piao Xiao contributes a slightly different angle: in addition to its Phlegm-resolving quality, it has a Blood-moving capacity that helps break down more established or stubborn masses where Blood stasis may coexist with Phlegm congestion.

Assistant herbs

Qing Mu Xiang (reinforcing type) addresses the root cause by coursing Liver Qi and relieving emotional constraint. Without resolving the Qi stagnation that generates Phlegm, the nodules would simply recur. Chen Pi (reinforcing type) regulates Qi flow in the middle burner, dries Dampness, and transforms Phlegm, supporting the Spleen to cut off the source of Phlegm production. Hai Ge Fen (reinforcing type) adds a Heat-clearing dimension to the Phlegm-dissolving action, addressing any Heat that may have developed within the stagnant Phlegm.

Notable synergies

The pairing of Hai Zao with Kun Bu is a classical combination for softening hardness and dissolving Phlegm nodules, where their combined effect exceeds what either achieves alone. The pairing of Qing Mu Xiang with Chen Pi creates a comprehensive Qi-regulating team that addresses both Liver constraint (the trigger) and Spleen Dampness (the Phlegm source), ensuring the root cause is treated alongside the manifestation.

How to Prepare

Traditional preparation instructions for Si Hai Shu Yu Wan

Grind all ingredients into a fine powder and form into pills. The four sea-product herbs (Hai Dai, Hai Zao, Kun Bu, Hai Piao Xiao) should first be rinsed with boiling water to remove excess salt before drying and grinding.

Take 6 to 9 grams per dose, three times daily, swallowed with warm water or rice wine. The residue that settles at the bottom of the bowl can be applied externally to the swollen area on the neck.

In modern clinical practice, the formula is often adapted as a decoction (water-boiled preparation). After the condition has resolved, a follow-up remedy of Huang Yao Zi (120g) simmered in raw wine can be taken morning and evening to consolidate the results and prevent recurrence.

Common Modifications

How practitioners adapt Si Hai Shu Yu Wan for specific situations

Added
Chai Hu

9-12g, strongly courses the Liver and relieves constraint

Xiang Fu

9-12g, moves Qi and soothes the Liver

Yu Jin

9-12g, moves Qi and Blood, resolves depression

When emotional stagnation is the dominant driving factor, stronger Liver-coursing herbs are added to more aggressively address the root cause of Qi constraint.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Si Hai Shu Yu Wan should not be used or requires extra caution

Avoid

Yin deficiency with Fire flaring (阴虚火旺) patterns. The formula addresses Qi stagnation and Phlegm accumulation; it is not appropriate for goiter or nodules caused primarily by Yin deficiency with rising Fire, where the tongue is red with little coating and the pulse is rapid and thin.

Caution

Spleen and Stomach deficiency with cold. The formula contains multiple salty, cold, marine-origin substances (Hai Dai, Hai Zao, Kun Bu, Hai Ge Fen) that can further weaken an already cold and deficient digestive system. If the patient has loose stools, poor appetite, or a pale tongue with white coating, this formula should be used with great caution or combined with Spleen-warming herbs.

Avoid

Hyperthyroidism (Graves' disease). The marine herbs in this formula are rich in iodine. In patients with hyperthyroidism, additional iodine intake may worsen the condition. Modern medical assessment should be integrated before use.

Avoid

Pregnancy. Several ingredients in the formula (Hai Zao, Kun Bu, Qing Mu Xiang) have properties that may be unsuitable during pregnancy. Hai Zao in particular is traditionally listed as contraindicated with Gan Cao and carries cautions in pregnancy.

Caution

Blood stasis dominant patterns. If the goiter or nodule is primarily characterized by fixed, sharp pain, dark purple tongue, and choppy pulse indicating predominant Blood stasis rather than Qi stagnation with Phlegm, this formula alone will be insufficient and a Blood-moving formula is more appropriate.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. The formula contains Hai Zao (Sargassum), Kun Bu (Kelp), and Hai Dai (Laminaria), which are salty and cold marine substances that are traditionally used with caution in pregnancy. Qing Mu Xiang (Aristolochia root) is particularly concerning, as species in the Aristolochia genus contain aristolochic acid, which is nephrotoxic and potentially teratogenic. The overall cold, Phlegm-dissolving, and nodule-dispersing action of the formula is contrary to the principle of protecting fetal Qi during pregnancy. Pregnant women should not take this formula.

Breastfeeding

Use with caution during breastfeeding. The marine-origin herbs (Hai Zao, Kun Bu, Hai Dai) are very high in iodine, which transfers into breast milk and may affect the nursing infant's thyroid function. Qing Mu Xiang (Aristolochia root) is of particular concern due to its aristolochic acid content, which could potentially pass into breast milk. If this formula is clinically necessary during breastfeeding, the practitioner should consider substituting Qing Mu Xiang with a safer Qi-moving herb (such as Mu Xiang from the Aucklandia/Vladimiria family) and monitor the infant for any signs of thyroid dysfunction or digestive disturbance. A qualified practitioner should supervise use.

Children

This formula is occasionally used in adolescents with thyroid enlargement or nodules presenting with the Qi stagnation and Phlegm accumulation pattern. Dosage should be reduced to approximately one-third to one-half of the adult dose depending on the child's age and weight. The formula's cold, salty marine herbs can easily burden a child's developing digestive system, so it should only be used under close practitioner supervision and for limited durations. Qing Mu Xiang (Aristolochia) should ideally be substituted with a safer alternative in pediatric use due to concerns about aristolochic acid nephrotoxicity. Not recommended for children under 6 years of age.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Si Hai Shu Yu Wan

Thyroid medications (Levothyroxine, Methimazole, Propylthiouracil): The marine herbs Hai Zao, Kun Bu, Hai Dai, and Hai Ge Fen are all naturally high in iodine. Concurrent use with thyroid hormone replacement (e.g. levothyroxine) or anti-thyroid drugs (e.g. methimazole) may interfere with thyroid function management and alter drug efficacy. Patients on thyroid medication should have their thyroid function closely monitored if taking this formula.

Anticoagulants and antiplatelet drugs (Warfarin, Aspirin, Clopidogrel): Hai Zao (Sargassum) has been reported to have mild anticoagulant effects. Concurrent use with blood-thinning medications may theoretically increase bleeding risk.

Aristolochic acid concerns (Qing Mu Xiang): If the formula uses Qing Mu Xiang derived from Aristolochia debilis, it contains aristolochic acid, which is nephrotoxic and potentially carcinogenic. This may interact adversely with any drugs that are nephrotoxic or hepatotoxic, compounding organ damage. Many modern practitioners substitute Chuan Mu Xiang (Vladimiria souliei) or other safe alternatives to avoid this risk entirely.

Usage Guidance

Practical advice for getting the most out of Si Hai Shu Yu Wan

Best time to take

Three times daily with warm water, taken 30 minutes after meals to protect the Stomach from the cold, salty nature of the marine herbs.

Typical duration

Typically taken for 4 to 12 weeks, with reassessment by a practitioner every 2 to 4 weeks to monitor nodule response.

Dietary advice

While taking this formula, avoid foods that generate Phlegm or worsen Qi stagnation. This includes greasy, fried, and rich foods, dairy products, excessive sweets, and alcohol. Cold and raw foods should also be limited, as they can further impair the Spleen's fluid-processing function and worsen Phlegm production. Foods that support the formula's action are helpful: seaweed and kelp in moderation (unless hyperthyroid), radishes, mustard greens, and citrus peel tea, which all help move Qi and resolve Phlegm. Maintaining regular mealtimes and eating in a relaxed state supports the Liver-Spleen harmony the formula is trying to restore. Emotional regulation is equally important. Since this condition is driven by emotional constraint, reducing stress, practicing gentle exercise, and avoiding excessive rumination or anger will significantly support the formula's therapeutic effect.

Si Hai Shu Yu Wan originates from Yáng Yī Dà Quán (疡医大全, Complete Collection of Sore Medicine), Volume 18, by Gù Shìchéng (顾世澄) Qīng dynasty, 1760 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Si Hai Shu Yu Wan and its clinical use

Original source text from the Yang Yi Da Quan (《疡医大全》):

「治肝脾气郁,致患气瘿,结喉之间,气结如胞,随喜怒消长,甚则妨碍饮食。」

Translation: "Treats Liver and Spleen Qi depression that gives rise to Qi goiter. Between the throat and the Adam's apple, Qi congeals into a pouch-like mass that grows and shrinks with joy and anger. In severe cases it obstructs eating and drinking."


Classical disease context from the Ji Sheng Fang (《济生方·瘿瘤论治》):

「夫瘿瘤者,多由喜怒不节,忧思过度,而成斯疾焉。……气凝血滞,为瘿为瘤。」

Translation: "Goiter and tumors mostly arise from unrestrained joy and anger, or excessive worry and brooding, which produce this illness. Qi congeals and Blood stagnates, forming goiter and tumors."

Historical Context

How Si Hai Shu Yu Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Si Hai Shu Yu Wan (四海舒郁丸, "Four Seas Soothe Depression Pill") was recorded in the Yang Yi Da Quan (《疡医大全》, "Complete Compendium of Ulcer Medicine"), a monumental surgical and external medicine text compiled by Gu Shicheng (顾世澄, courtesy name Lianjiang 练江) during the Qing Dynasty. Gu was from Wuhu, Anhui, born into a family of physicians, and later practiced in Yangzhou for over 40 years. The text was completed in 1760 (Qianlong 25th year) and encompasses 40 volumes covering external diseases from head to toe.

The formula's name is distinctive: "Si Hai" (Four Seas) refers to the four marine-origin medicinals that form the backbone of the prescription (Hai Dai, Hai Zao, Hai Ge Fen, and Hai Piao Xiao), while "Shu Yu" means to soothe or disperse depression/stagnation. This naming convention reflects the formula's core strategy of using ocean-derived substances, rich in minerals and natural iodine, to dissolve the Phlegm nodules that result from emotional stagnation. The use of marine herbs for goiter has deep roots in Chinese medical history. Related earlier formulas such as Xiao Ying San (《证治准绳》) and Xiao Ying Wu Hai Yin (《古今医鉴》) also centered on combinations of seaweed, kelp, and shellfish. Si Hai Shu Yu Wan became the representative formula for the "Qi stagnation and Phlegm accumulation" (气郁痰阻) pattern of goiter disease, and in modern practice it is the principal formula used for benign thyroid nodules and simple goiter of this pattern type.