Shi Quan Da Bu Tang

All-Inclusive Great Tonifying Decoction · 十全大补汤

Also known as: Shi Quan Yin (十全饮, All-Inclusive Tonifying Drink), Shi Bu Tang (十补汤, Ten Tonics Decoction), Shi Quan Da Bu Wan (十全大补丸, All-Inclusive Great Tonifying Pill),

A classical warming and tonifying formula used to rebuild both Qi and Blood in people suffering from deep exhaustion, pallor, cold limbs, poor appetite, and general weakness. It combines the Qi-boosting herbs of Si Jun Zi Tang with the Blood-nourishing herbs of Si Wu Tang, plus Huang Qi and Rou Gui for extra warming power. Commonly used after prolonged illness, surgery, or cancer treatment to restore vitality.

Origin Tài Píng Huì Mín Hé Jì Jú Fāng (太平惠民和剂局方) — Sòng dynasty, 1107-1110 CE
Composition 10 herbs
Ren Shen
King
Ren Shen
Shu Di Huang
King
Shu Di Huang
Bai Zhu
Deputy
Bai Zhu
Dang Gui
Deputy
Dang Gui
Huang Qi
Assistant
Huang Qi
Bai Shao
Assistant
Bai Shao
Fu Ling
Assistant
Fu Ling
Chuan Xiong
Assistant
Chuan Xiong
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Shi Quan Da Bu Tang is designed to correct these specific patterns.

Why Shi Quan Da Bu Tang addresses this pattern

Qi and Blood Deficiency is the core pattern this formula was designed to treat. When both Qi and Blood are depleted, the body loses its ability to warm the limbs, nourish the complexion, maintain mental alertness, and sustain physical strength. The Spleen (the source of Qi and Blood production) is weakened, leading to poor appetite and fatigue, while the Heart and Liver (which govern Blood and spirit) cannot be properly nourished, causing palpitations, dizziness, and emotional fragility.

Shi Quan Da Bu Tang addresses this by simultaneously rebuilding Qi through Ren Shen, Huang Qi, Bai Zhu, and Fu Ling, and replenishing Blood through Shu Di Huang, Dang Gui, Bai Shao, and Chuan Xiong. The addition of Rou Gui adds warming support, which is essential because severe Qi and Blood deficiency often leads to internal Cold.

A practitioner would look for one or more of these signs

Eye Fatigue

Deep, persistent tiredness worsened by exertion

Dull Pale Complexion

Sallow or yellowish pale face

Dizziness

Lightheadedness, especially on standing

Palpitations

Heart palpitations with a sensation of anxiety

Shortness Of Breath

Breathlessness on mild activity

Poor Appetite

Reduced desire to eat

Cold Limbs

Hands and feet that are consistently cold

Spontaneous Sweat

Sweating without exertion, especially daytime

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Shi Quan Da Bu Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, anemia most closely corresponds to Blood Deficiency, often accompanied by Qi Deficiency. The Spleen is responsible for transforming food into Qi and Blood. When Spleen Qi is weak, the body cannot produce enough Blood, leading to pallor, dizziness, fatigue, and palpitations. If the condition persists, the Heart and Liver lose their nourishment, and Yang warmth declines, producing cold limbs and a general sense of depletion.

Why Shi Quan Da Bu Tang Helps

Shi Quan Da Bu Tang directly addresses the two components of anemia from a TCM perspective: insufficient Blood production and inadequate Qi to move it. Shu Di Huang, Dang Gui, Bai Shao, and Chuan Xiong directly replenish and circulate the Blood. Ren Shen, Huang Qi, Bai Zhu, and Fu Ling strengthen the Spleen to improve the body's long-term capacity to generate Blood from food. Rou Gui warms the interior, which in TCM theory is essential because a cold Spleen cannot adequately produce Blood. Modern research has shown the formula can increase hemoglobin, red blood cell counts, and platelet levels.

Also commonly used for

Poor Appetite

Appetite loss due to Spleen Qi deficiency

Irregular Menstruation

Scanty or absent periods from Blood deficiency

Postmenstrual Bleeding

Uterine bleeding from failure of Qi to hold Blood

Night Sweats

Night sweats in the context of deficiency

Spontaneous Sweat

Daytime sweating without exertion

Palpitations

Heart palpitations from Blood deficiency

Dizziness

Lightheadedness from Blood failing to nourish the head

Low Blood Pressure

Hypotension associated with Qi deficiency

Hair Loss

Hair thinning from Blood deficiency

What This Formula Does

Every TCM formula has a specific set of actions — here's what Shi Quan Da Bu Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Shi Quan Da Bu Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Shi Quan Da Bu Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Shi Quan Da Bu Tang works at the root level.

This formula addresses a pattern of dual deficiency of both Qi and Blood (气血两虚), often with an underlying tendency toward internal Cold. In TCM theory, Qi and Blood are deeply interdependent: Qi is the motive force that generates and circulates Blood, while Blood is the material basis that nourishes and anchors Qi. When a person suffers from prolonged illness, excessive blood loss (such as heavy menstruation or surgical bleeding), chronic overwork, or emotional strain, both Qi and Blood can become depleted simultaneously. The Spleen, which is the central organ responsible for generating both Qi and Blood from food, becomes weakened and can no longer produce sufficient nourishment for the body.

As Qi and Blood decline together, a cascade of symptoms develops. Without enough Blood, the complexion becomes sallow and pale, there is dizziness, blurred vision, and palpitations because the Heart and brain lack nourishment. Without enough Qi, the person feels constantly fatigued, short of breath, and has a weak voice and poor appetite. Because Qi also controls the body's warming function and the defensive exterior, deficient patients often feel cold in the limbs, sweat spontaneously or at night, and are more vulnerable to illness. In severe or chronic cases, the Kidney Yang, the deepest source of warmth in the body, also weakens, leading to low back and knee soreness, cold extremities, and reduced vitality.

The formula works by rebuilding both Qi and Blood from their respective sources (the Spleen for Qi, the Liver and Kidneys for Blood) while adding a warming component that gently kindles the body's internal fire. This restores the generative cycle: a stronger Spleen produces more Qi and Blood, warmer Yang ensures that these substances circulate properly, and with adequate Qi and Blood flowing again, the organs resume their normal functions and the body can heal wounds, regulate menstruation, and resist disease.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly sweet and warm, with mild bitter and pungent notes. The sweet taste tonifies and nourishes Qi and Blood, the pungent taste (from Rou Gui and Chuan Xiong) promotes circulation, and the mild bitterness (from Bai Zhu) supports Spleen drying.

Channels Entered

Ingredients

10 herbs

The herbs that make up Shi Quan Da Bu Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Ren Shen

Ren Shen

Ginseng root

Dosage 6 - 10g
Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys

Role in Shi Quan Da Bu Tang

Powerfully tonifies the primal Qi, strengthens the Spleen and Lung, and serves as the chief Qi-supplementing herb in the formula. It addresses the root deficiency that underlies the entire pattern.
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 9 - 12g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Shi Quan Da Bu Tang

The primary Blood-nourishing herb. Prepared Rehmannia richly nourishes the Blood and Yin of the Liver and Kidney, addressing the Blood deficiency aspect of the pattern.
Deputies — Assists and enhances the King
Bai Zhu

Bai Zhu

White Atractylodes rhizome

Dosage 9 - 10g
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach

Role in Shi Quan Da Bu Tang

Strengthens the Spleen and dries Dampness, assisting Ren Shen in tonifying Qi and ensuring the digestive system can generate Qi and Blood from food.
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 9 - 10g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Shi Quan Da Bu Tang

Nourishes and invigorates the Blood, entering the Liver and Heart channels. Assists Shu Di Huang in replenishing Blood while also gently promoting Blood circulation to prevent stagnation from the rich tonics.
Assistants — Supports or moderates other herbs
Huang Qi

Huang Qi

Astragalus root

Dosage 9 - 12g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs

Role in Shi Quan Da Bu Tang

Strongly tonifies Qi and raises Yang, reinforcing the exterior and stabilizing the Wei Qi to address spontaneous sweating. Works alongside Ren Shen to greatly amplify the Qi-tonifying power of the formula.
Bai Shao

Bai Shao

White peony root

Dosage 9 - 10g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen

Role in Shi Quan Da Bu Tang

Nourishes the Blood and preserves Yin, softens the Liver and alleviates pain. Complements the Blood-tonifying action of Shu Di Huang and Dang Gui while helping to consolidate Yin fluids.
Fu Ling

Fu Ling

Poria

Dosage 9 - 10g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Shi Quan Da Bu Tang

Strengthens the Spleen and promotes water metabolism. Prevents the rich, cloying Blood tonics from causing Dampness, and assists Ren Shen and Bai Zhu in supporting the digestive transformation.
Chuan Xiong

Chuan Xiong

Sichuan lovage rhizome

Dosage 5 - 6g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium

Role in Shi Quan Da Bu Tang

Invigorates the Blood and promotes the movement of Qi. Its pungent, moving nature prevents the heavy tonifying herbs from creating stagnation, ensuring the new Blood and Qi circulate freely.
Rou Gui

Rou Gui

Cinnamon bark

Dosage 2 - 3g
Temperature Hot
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Liver, Spleen, Kidneys

Role in Shi Quan Da Bu Tang

Warms the Yang, dispels interior Cold, and warms the channels to promote Blood circulation. Its hot nature activates the warming aspect of the formula, embodying the principle that Yang warmth generates Yin substance.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 5g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Shi Quan Da Bu Tang

Honey-prepared licorice tonifies the Spleen Qi, harmonizes all the other herbs in the formula, and moderates the drying or draining properties of certain ingredients.

Why This Combination Works

How the herbs in Shi Quan Da Bu Tang complement each other

Overall strategy

This formula addresses severe deficiency of both Qi and Blood with an underlying tendency toward Cold. It combines a complete Qi-tonifying formula (Si Jun Zi Tang) with a complete Blood-nourishing formula (Si Wu Tang), then adds Huang Qi and Rou Gui to strengthen the warming, Yang-supporting dimension, so that the body's capacity to generate and circulate Qi and Blood is fully restored.

King herbs

Ren Shen is the chief Qi tonic, powerfully replenishing the source Qi of the Spleen and Lung. Shu Di Huang is the chief Blood tonic, richly nourishing the Blood and Yin of the Liver and Kidney. Together, these two herbs address the dual root deficiency: Qi failing to move and warm the body, and Blood failing to nourish the organs and tissues.

Deputy herbs

Bai Zhu reinforces Ren Shen by strengthening the Spleen's ability to transform food into Qi and Blood, while also drying any Dampness that might hinder digestion. Dang Gui assists Shu Di Huang by nourishing the Blood and gently activating its circulation, particularly in the Liver and Heart, ensuring new Blood reaches the organs that need it most.

Assistant herbs

Huang Qi (reinforcing) amplifies the Qi-tonifying action, raises Yang Qi to address fatigue and spontaneous sweating, and strengthens the body's defensive exterior. Bai Shao (reinforcing) nourishes Blood and consolidates Yin alongside the other Blood tonics. Fu Ling (reinforcing) supports the Spleen's water metabolism and prevents the rich, heavy tonics from generating unwanted Dampness. Chuan Xiong (counteracting) uses its pungent, moving nature to keep Qi and Blood circulating freely, preventing the heavy nourishing herbs from causing stagnation. Rou Gui (reinforcing) adds crucial Yang warmth, warms the channels, and supports the classical principle that warming Yang helps generate Yin ("Yang generates Yin" or yang sheng yin zhang).

Envoy herbs

Zhi Gan Cao (honey-prepared licorice) harmonizes all the herbs, tonifies the Middle Burner, and moderates the drying and draining qualities of some ingredients so the formula works as a balanced whole.

Notable synergies

The Ren Shen plus Huang Qi pairing creates an exceptionally strong Qi-tonifying effect, far exceeding what either herb achieves alone. The Shu Di Huang plus Dang Gui pairing deeply nourishes Blood while gently moving it. Rou Gui paired with the Blood-nourishing herbs embodies a key principle: by warming the Yang, the cold and cloying Blood tonics are activated and better absorbed. Chuan Xiong's mobile nature paired with the otherwise still and heavy Shu Di Huang ensures Blood nourishment reaches all parts of the body rather than stagnating.

How to Prepare

Traditional preparation instructions for Shi Quan Da Bu Tang

In the original source text, all ten herbs are ground into a coarse powder in equal parts. For each dose, approximately 6-9g of the powder is cooked with three slices of fresh ginger (Sheng Jiang) and two pieces of Chinese date (Da Zao) in one bowl of water. The liquid is simmered until reduced to about 70% of the original volume, then strained and taken warm, without regard to timing relative to meals.

In modern clinical practice, the herbs are typically used as whole decoction pieces in adjusted dosages rather than equal parts. They are decocted in approximately 600-800ml of water, brought to a boil, then simmered on low heat for 30-40 minutes, strained, and taken in two divided doses morning and evening. Fresh ginger and dates are still commonly added as adjuncts.

Common Modifications

How practitioners adapt Shi Quan Da Bu Tang for specific situations

Added
Fu Xiao Mai

30g, stabilizes the exterior and stops sweating

Wu Wei Zi

6-10g, astringes Lung Qi and secures fluids

Fu Xiao Mai and Wu Wei Zi both have astringent properties that help contain the body's fluids. When Qi is too weak to hold the pores closed, sweating increases. These herbs secure the exterior while the base formula rebuilds the underlying Qi.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Shi Quan Da Bu Tang should not be used or requires extra caution

Avoid

Excess Heat or Toxic Heat patterns (e.g. high fever due to external invasion, acute infections with inflammatory signs). This heavily warming, tonifying formula would trap Heat and worsen the condition.

Avoid

Yin Deficiency with Empty Fire (阴虚火旺). The warm and drying nature of Huang Qi, Ren Shen, and especially Rou Gui can further deplete Yin fluids and fan Empty Fire, worsening symptoms like night sweats, hot flashes, and a red tongue with little coating.

Caution

Dampness, Phlegm-Dampness, or Damp-Heat accumulation. The rich, cloying herbs (Shu Di Huang, Dang Gui) can aggravate Dampness and impair Spleen transport, causing bloating, loose stools, and a greasy tongue coating.

Caution

Active bleeding due to Blood Heat. While the formula treats deficiency-type bleeding (崩漏), it should not be used if bleeding is caused by Heat forcing Blood out of the vessels, as its warming properties could intensify hemorrhage.

Caution

Patients with hypertension or prone to Liver Yang Rising. Ren Shen and Huang Qi can raise blood pressure, and the overall warm-tonifying nature may aggravate headache, dizziness, and facial flushing associated with ascending Yang.

Caution

Indigestion or food stagnation. When the Spleen and Stomach are congested with undigested food, the heavy tonifying herbs will further burden digestion. The stagnation should be resolved first before using this formula.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe with appropriate supervision, but use with caution. The formula itself is not abortifacient and was historically used to support depleted constitutions in women. However, Rou Gui (Cinnamon Bark) has Blood-moving and warming properties that theoretically could stimulate uterine activity, and Chuan Xiong (Ligusticum) is a Blood-activating herb. Dang Gui (Angelica sinensis) also promotes blood circulation. While these herbs are used at moderate doses within this formula's tonifying context, pregnant women should only take Shi Quan Da Bu Tang under the guidance of a qualified practitioner who can assess the individual situation. It should not be used during the first trimester without clear clinical need. Toxicology studies on the Japanese Kampo version (Juzen-taiho-to) have not revealed significant teratogenic toxicity at normal doses.

Breastfeeding

Generally considered compatible with breastfeeding when used under practitioner supervision. The formula's constituent herbs are traditionally used in the postpartum period to help replenish Qi and Blood after childbirth and may support milk production by strengthening the Spleen's ability to generate Blood (which is the material basis for breast milk in TCM). Ren Shen (Ginseng) and Huang Qi are commonly used in postpartum recovery formulas. However, the warming nature of the formula could theoretically make breast milk warmer in quality, which may not suit infants showing signs of Heat (restlessness, skin rashes). There are no well-documented adverse effects on nursing infants. Use at standard doses and monitor the infant for any signs of irritability or digestive upset. Children, pregnant women, and breastfeeding women should use this formula under qualified practitioner guidance.

Children

Shi Quan Da Bu Tang can be used in children but requires significant dose reduction based on age and body weight. A common guideline is to use approximately one-quarter to one-third of the adult dose for children aged 6-12 years, and one-sixth or less for children under 6 years. Children's constitutions tend to run warmer and their Spleen function is still developing, so the warming and cloying nature of this formula can easily cause digestive upset, restlessness, or signs of Heat (nosebleeds, mouth sores). It is most appropriate for children who clearly show Qi and Blood deficiency with Cold signs, such as those recovering from prolonged illness, chronic anemia, or failure to thrive. It is not suitable as a general children's tonic. The formula should only be administered to children under the guidance of a qualified practitioner, and the dose of Rou Gui (Cinnamon Bark) in particular should be kept small.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Shi Quan Da Bu Tang

Anticoagulants and antiplatelet drugs (e.g. warfarin, heparin, aspirin, clopidogrel): Dang Gui (Angelica sinensis) and Chuan Xiong (Ligusticum) have documented blood-activating properties. Combined use may increase bleeding risk. Patients on anticoagulant therapy should be monitored for changes in INR or signs of unusual bleeding.

Antihypertensives: Ren Shen (Ginseng) and Huang Qi (Astragalus) can raise blood pressure in some individuals, potentially counteracting the effects of antihypertensive medications. Blood pressure should be monitored when co-administering.

Hypoglycemic agents (insulin, metformin, sulfonylureas): Ren Shen (Ginseng) has blood sugar-lowering effects and may potentiate hypoglycemic drugs, increasing the risk of low blood sugar. Blood glucose monitoring is advisable.

Corticosteroids and immunosuppressants: Gan Cao (Glycyrrhiza/Licorice) contains glycyrrhizin, which can cause pseudoaldosteronism (potassium loss, sodium retention, edema, elevated blood pressure). This risk is increased with concurrent corticosteroid use. Glycyrrhizin may also affect the metabolism of certain corticosteroids.

Digoxin and cardiac glycosides: Gan Cao-induced hypokalemia can potentiate digoxin toxicity. Electrolyte levels should be monitored.

Diuretics: The potassium-depleting effect of Gan Cao may be worsened by concurrent thiazide or loop diuretics, increasing the risk of hypokalemia.

Usage Guidance

Practical advice for getting the most out of Shi Quan Da Bu Tang

Best time to take

30 minutes to 1 hour before meals, twice daily (morning and early evening), taken warm. The original text states 'take warm, without regard to time' (不拘时候温服).

Typical duration

Typically taken for 2-8 weeks as a course of treatment, then reassessed. For chronic deficiency conditions, it may be taken intermittently over several months with periodic breaks.

Dietary advice

While taking this formula, favor warm, easily digestible foods that support the Spleen and Stomach: cooked grains (rice, millet, oats), soups, stews, root vegetables, chicken, lamb, dates, and longan fruit. Avoid cold and raw foods (salads, ice cream, cold drinks, raw fish) as these can obstruct the Spleen's warming and transforming function and reduce the formula's effectiveness. Also avoid greasy, heavy, or overly rich foods, which can generate Dampness and Phlegm that counteract the tonifying herbs. Limit spicy, hot, or excessively drying foods (chili, alcohol, fried foods) as the formula is already warming. Green tea and strongly cooling foods (watermelon, bitter melon, mung beans) are best avoided in large amounts as they may undermine the warming therapeutic direction.

Shi Quan Da Bu Tang originates from Tài Píng Huì Mín Hé Jì Jú Fāng (太平惠民和剂局方) Sòng dynasty, 1107-1110 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Shi Quan Da Bu Tang and its clinical use

《太平惠民和剂局方》卷五 (Tài Píng Huì Mín Hé Jì Jú Fāng, Volume 5):

「治男子、妇人诸虚不足,五劳七伤,不进饮食,久病虚损,时发潮热,气攻骨脊,拘急疼痛,夜梦遗精,面色萎黄,脚膝无力,一切病后气不如旧,忧愁思虑伤动血气,喘嗽中满,脾肾气弱,五心烦闷,并皆治之。此药性温不热,平补有效,养气育神,醒脾止渴,顺正辟邪,温暖脾肾,其效不可具述。」

Translation: "Treats all types of deficiency in men and women: the five taxations and seven damages, poor appetite, prolonged illness with weakened constitution, intermittent tidal fever, Qi attacking the spine and bones, cramping pain, nocturnal emissions, sallow complexion, weakness in the legs and knees, failure to recover after any illness, grief and excessive thinking that injure Qi and Blood, wheezing and chest fullness, weakness of the Spleen and Kidneys, and irritability with heat in the five centers. This medicine is warm but not hot, a gentle tonic that is effective: it nourishes Qi, cultivates the spirit, rouses the Spleen, stops thirst, supports the upright and dispels the pathogenic, and warms the Spleen and Kidneys. Its effects are beyond enumeration."

清·张秉成《成方便读》(Qīng Dynasty, Zhāng Bǐngchéng, Chéng Fāng Biàn Dú):

「八珍并补气血之功,固无论矣。而又加黄芪助正气以益卫,肉桂温血脉而和营,且各药得温养之力,则补性愈足,见效愈多。」

Translation: "The power of Ba Zhen Tang to tonify both Qi and Blood goes without saying. Adding Huang Qi assists the upright Qi to strengthen the defensive exterior, while Rou Gui warms the blood vessels to harmonize the nutritive layer. Moreover, with the warming and nourishing support, the tonifying power of all the herbs is enhanced, and the results are even greater."

Historical Context

How Shi Quan Da Bu Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Shi Quan Da Bu Tang (十全大补汤, "All-Inclusive Great Tonifying Decoction") first appeared in the Tai Ping Hui Min He Ji Ju Fang (《太平惠民和剂局方》), China's first nationally issued pharmacopoeia of prepared medicines, compiled during the Song Dynasty (around 1107-1110 CE and revised in subsequent editions). The Song emperors actively encouraged the collection of medical recipes from across the empire, and the Imperial Medical Bureau organized them into this landmark compendium. The formula's alternative names include Shi Quan Yin (十全饮) and Shi Bu Tang (十补汤).

The formula is elegantly constructed by combining two of the most fundamental formulas in Chinese medicine: Si Jun Zi Tang (Four Gentlemen Decoction) for Qi tonification and Si Wu Tang (Four Substances Decoction) for Blood nourishment, together forming Ba Zhen Tang (Eight Treasure Decoction), plus two additional herbs, Huang Qi and Rou Gui, to strengthen defensive Qi and warm the Yang. Its reputation was so great that it was historically described as capable of "raising the dead and putting flesh back on bones" (起死人而肉白骨). In Japan, it became one of the most studied Kampo formulas under the name Juzen-taiho-to (TJ-48), and a dedicated scientific monograph was published (Yamada & Saiki, CRC Press, 2005). In Korea, it is known as Sipjeondaebo-tang and remains one of the most widely prescribed traditional formulas, frequently depicted in Korean popular culture as a classic restorative remedy.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Shi Quan Da Bu Tang

1

Effectiveness of 3-Week Intervention of Shi Quan Da Bu Tang for Alleviating Hematotoxicity Among Patients With Breast Carcinoma Receiving Chemotherapy (Retrospective Cohort Study, 2013)

Huang SM, Chien LY, Tai CJ, Chiou JF, Chen CS, Tai CJ. Integrative Cancer Therapies. 2013;12(2):136-144.

This study examined breast cancer patients receiving chemotherapy who had low white blood cell counts. The group receiving SQDBT alongside chemotherapy showed better recovery of white blood cell counts and hemoglobin levels compared to the chemotherapy-only group, suggesting the formula may help protect the blood-forming system during cancer treatment.

Link
2

Shi-quan-da-bu-tang (SQT): A Potent Chinese Biological Response Modifier in Cancer Immunotherapy, Potentiation and Detoxification of Anticancer Drugs (Preclinical/Clinical Review, 1992)

Zee-Cheng RKY. Methods and Findings in Experimental and Clinical Pharmacology. 1992;14(9):725-736.

This early landmark review summarized eight years of animal and clinical research showing that SQDBT has extremely low toxicity, stimulates hematopoietic factors and interleukin production, potentiates the effects of chemotherapy drugs (including mitomycin, cisplatin, cyclophosphamide, and fluorouracil), and helps reduce their side effects such as nausea, bone marrow suppression, and kidney damage.

PubMed
3

Efficacy and Safety of Sipjeondaebo-Tang (Shi-Quan-Da-Bu-Tang) for Chronic Fatigue Syndrome: Study Protocol for a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial (RCT Protocol, 2020)

Oh S, Cheon C, Park S, et al. Evidence-Based Complementary and Alternative Medicine. 2020;2020:4708374.

This Korean study protocol describes a rigorous multicenter, double-blind, placebo-controlled trial designed to evaluate SQDBT for chronic fatigue syndrome. Ninety-six patients were to receive either SQDBT or placebo three times daily for 8 weeks, with fatigue measured by the Checklist Individual Strength questionnaire. The study reflects growing interest in evidence-based evaluation of this classical formula.

Link
4

A Narrative Review of the Immunomodulatory and Anticancer Activity of Some Components of Shi-Quan-Da-Bu-Tang (Narrative Review, 2021)

Bisogno I, Musumeci G, Nardone V. Longhua Chinese Medicine. 2021;4:4.

This review examined the immunomodulatory and anticancer properties of individual herbs within the formula. The authors found evidence that SQDBT can decrease cancer-related fatigue and pain, improve peripheral neuropathy, reduce gastrointestinal side effects of chemotherapy, and lower the incidence of bone marrow suppression.

Link

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.