Formula Pill (Wan)

Sheng Bai Wan

Raise the White (Blood Cell) Pill · 升白丸

Also known as: Pseudostellaria & Astragalus Combination

A modern formula designed to help people with low white blood cell counts, particularly those undergoing chemotherapy or radiation therapy. It works by strengthening the Spleen and Kidneys, nourishing Blood, and replenishing the body's marrow to support healthy blood cell production. It addresses the fatigue, pallor, dizziness, and poor appetite that commonly accompany blood deficiency.

Origin Modern clinical formula (现代经验方), published in the journal Shi Yong Zhong Xi Yi Jie He Za Zhi (实用中西医结合杂志), 1991 — Modern era, late 20th century
Composition 13 herbs
Huang Qi
King
Huang Qi
Tai Zi Shen
King
Tai Zi Shen
Bai Zhu
Deputy
Bai Zhu
Dang Gui
Deputy
Dang Gui
Shan Yao
Assistant
Shan Yao
Gou Qi Zi
Assistant
Gou Qi Zi
Nu Zhen Zi
Assistant
Nu Zhen Zi
He Shou Wu
Assistant
He Shou Wu
+5
more
Explore composition
Available in our store
View in Store
From $42.00

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Sheng Bai Wan is designed to correct these specific patterns.

Why Sheng Bai Wan addresses this pattern

This formula directly targets the dual deficiency of Spleen and Kidney that underlies leukopenia in TCM understanding. When the Spleen is weak, it cannot transform food into sufficient Qi and Blood. When the Kidneys lack Essence, they cannot generate marrow, which in TCM is the root of blood cell production. Huang Qi and Tai Zi Shen powerfully tonify Spleen Qi, while Bai Zhu strengthens its transformative function. The Kidney-nourishing group (Gou Qi Zi, Nu Zhen Zi, He Shou Wu, Huang Jing, Shan Yao) replenishes Kidney Yin and Essence, restoring the body's capacity to produce marrow and blood cells. This dual approach treats both the acquired (Spleen) and innate (Kidney) sources of Blood production.

A practitioner would look for one or more of these signs

Eye Fatigue

Pronounced tiredness worsened by exertion, due to both Qi and Essence depletion

Dizziness

Lightheadedness from insufficient Blood reaching the head

Poor Appetite

Reduced desire to eat from Spleen weakness

Dull Pale Complexion

Pallor indicating Blood deficiency

Lower Back Pain

Soreness and weakness of the lower back from Kidney deficiency

Loose Stools

From impaired Spleen transportation

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Sheng Bai Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, white blood cells are understood as part of the body's defensive Qi (Wei Qi) and are rooted in the Blood. Blood is generated through two mechanisms: the Spleen transforms dietary nutrients into Qi and Blood (the acquired source), while the Kidneys store Essence that generates marrow and blood (the innate source). When chemotherapy or radiation damages the body, it depletes both sources simultaneously. The Spleen's transformation function is impaired (leading to poor appetite, fatigue, and loose stools), and the Kidney Essence is consumed (leading to lower back weakness, dizziness, and diminished marrow function). The result is that the body loses its capacity to produce adequate blood cells, which TCM interprets as a collapse of the Qi-Blood-Essence axis.

Why Sheng Bai Wan Helps

Sheng Bai Wan rebuilds both sources of blood cell production simultaneously. Huang Qi and Tai Zi Shen restore Spleen Qi so the body can once again transform food into Qi and Blood. Shan Yao and Bai Zhu reinforce this digestive foundation. Meanwhile, Gou Qi Zi, Nu Zhen Zi, He Shou Wu, and Huang Jing replenish Kidney Yin and Essence, restoring the deeper root from which marrow and blood cells originate. Dang Gui and Ji Xue Teng directly nourish Blood and keep it circulating. Zhi Mu prevents the many tonics from generating unwanted Heat in patients who are often already Yin-depleted. This comprehensive approach addresses the root cause of leukopenia rather than simply stimulating short-term white cell production.

Also commonly used for

Anemia

Blood deficiency manifesting as low red blood cell counts alongside low white cells

Immunodeficiency

Weakened immune function following cancer treatment or chronic illness

Dizziness

Dizziness and lightheadedness accompanying blood cell deficiency

Poor Appetite

Reduced appetite from Spleen deficiency following aggressive medical treatments

What This Formula Does

Every TCM formula has a specific set of actions — here's what Sheng Bai Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Sheng Bai Wan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Sheng Bai Wan performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Sheng Bai Wan works at the root level.

In TCM understanding, leukopenia (low white blood cell count), whether arising from chemotherapy, radiation therapy, chronic illness, or other causes, reflects a deep depletion of the body's foundational resources. The Kidneys store Essence and govern the production of marrow. Bone marrow, in TCM theory, is the substance responsible for generating blood cells. When Kidney Essence is depleted, marrow production falters, and the body's ability to produce adequate blood cells diminishes.

Simultaneously, the Spleen plays a crucial role as the source of Qi and Blood generation. The Spleen transforms nutrients from food into Qi and Blood that nourish the entire body. When the Spleen is weakened — whether from the disease itself, the toxic side effects of treatment, or constitutional deficiency — the raw materials needed to produce Blood and support marrow function become insufficient. This creates a pattern of dual Spleen and Kidney deficiency with Qi and Blood insufficiency.

The resulting clinical picture includes pallor, fatigue, dizziness, poor appetite, and increased vulnerability to infection — all signs of the body's defensive and nutritive Qi being compromised. Sheng Bai Wan addresses this pathomechanism by simultaneously fortifying the Spleen's generating capacity and replenishing Kidney Essence and marrow, while nourishing Blood and Yin to restore the body's ability to produce white blood cells from within.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly sweet and slightly bitter — sweet to tonify Qi, Blood, and Essence, slightly bitter to clear residual Heat and support Yin.

Channels Entered

Ingredients

13 herbs

The herbs that make up Sheng Bai Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Huang Qi

Huang Qi

Astragalus root

Dosage 15 - 30g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs

Role in Sheng Bai Wan

Honey-processed Astragalus is the primary Qi tonic in this formula. It powerfully supplements Qi, strengthens the Spleen, and raises Yang, supporting the body's capacity to generate Blood and white blood cells. It is the chief herb driving the formula's immune-supporting function.
Tai Zi Shen

Tai Zi Shen

Pseudostellaria root (Prince ginseng)

Dosage 15 - 30g
Temperature Neutral
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs

Role in Sheng Bai Wan

Pseudostellaria root gently tonifies both Qi and Yin of the Spleen and Lungs. It works alongside Huang Qi to build the Qi foundation without being overly warming or drying, making it suitable for patients weakened by illness or cancer treatment.
Deputies — Assists and enhances the King
Bai Zhu

Bai Zhu

White Atractylodes rhizome

Dosage 9 - 15g
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach

Role in Sheng Bai Wan

Dry-fried Atractylodes strengthens the Spleen and dries Dampness, supporting the digestive system's ability to transform nutrients and generate Qi and Blood. It reinforces the Qi-tonifying action of the King herbs.
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 9 - 12g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Sheng Bai Wan

Angelica root nourishes and invigorates Blood, preventing stasis while building new Blood. It complements the Qi-tonifying herbs by providing the Blood-nourishing component essential for restoring blood cell counts.
Assistants — Supports or moderates other herbs
Shan Yao

Shan Yao

Chinese yam

Dosage 12 - 15g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs, Kidneys

Role in Sheng Bai Wan

Chinese yam tonifies the Spleen, Lungs, and Kidneys simultaneously. It bridges the Spleen-tonifying and Kidney-nourishing strategies of this formula, supporting the production of Essence (Jing) that generates marrow and Blood.
Gou Qi Zi

Gou Qi Zi

Chinese Wolfberry Fruit

Dosage 9 - 15g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys, Lungs

Role in Sheng Bai Wan

Goji berry nourishes Liver and Kidney Yin and supplements Blood. It helps replenish the Essence stored in the Kidneys that is essential for marrow production and blood cell generation.
Nu Zhen Zi

Nu Zhen Zi

Glossy privet fruit

Dosage 9 - 15g
Temperature Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Liver, Kidneys

Role in Sheng Bai Wan

Wine-processed Ligustrum fruit nourishes Liver and Kidney Yin. It works alongside Gou Qi Zi and Huang Jing to replenish the Yin and Essence foundation that supports marrow and blood production.
He Shou Wu

He Shou Wu

Fo-Ti root

Dosage 9 - 15g
Temperature Slightly Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān), Astringent (涩 sè)
Organ Affinity Liver, Kidneys

Role in Sheng Bai Wan

Prepared Polygonum root tonifies the Liver and Kidneys, nourishes Blood, and supplements Essence. Its Blood-nourishing and Essence-replenishing actions support the restoration of healthy blood cell production.
Huang Jing

Huang Jing

Siberian Solomon's Seal rhizome

Dosage 9 - 15g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs, Kidneys

Role in Sheng Bai Wan

Wine-processed Polygonatum tonifies the Spleen Qi while nourishing Kidney Yin and Essence. It strengthens the link between acquired (Spleen) and innate (Kidney) sources of nourishment for blood production.
Ji Xue Teng

Ji Xue Teng

Spatholobus stem

Dosage 15 - 30g
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Heart, Liver, Kidneys

Role in Sheng Bai Wan

Spatholobus stem invigorates and nourishes Blood, unblocks the channels, and promotes circulation. It ensures the newly generated Blood circulates freely and addresses any Blood stasis that may impede recovery.
Zhi Mu

Zhi Mu

Anemarrhena rhizome

Dosage 6 - 9g
Temperature Cold
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Lungs, Stomach, Kidneys

Role in Sheng Bai Wan

Anemarrhena rhizome clears Heat and nourishes Yin. It serves as a restraining assistant, preventing the many warming tonic herbs from generating Heat, and addressing the Yin deficiency often seen after chemotherapy or radiation.
Ban Xia

Ban Xia

Pinellia tuber

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs

Role in Sheng Bai Wan

Processed Pinellia dries Dampness and harmonizes the Stomach. It prevents the rich, cloying tonic herbs from overwhelming digestion, ensuring the formula can be absorbed and its nourishment properly distributed.
Envoy — Directs the formula to its target
Chen Pi

Chen Pi

Tangerine peel

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Spleen

Role in Sheng Bai Wan

Dry-fried tangerine peel regulates Qi and harmonizes the Middle Burner. It prevents stagnation from the many tonifying herbs, ensuring smooth Qi movement so that the nourishment can reach the marrow and blood.

Why This Combination Works

How the herbs in Sheng Bai Wan complement each other

Overall strategy

Sheng Bai Wan addresses leukopenia (low white blood cells) caused by dual deficiency of the Spleen and Kidneys, with insufficient Blood and Essence to support marrow function. The formula simultaneously tonifies Spleen Qi (to generate Blood from dietary sources) and nourishes Kidney Yin and Essence (to replenish marrow, the root of blood cell production), while invigorating Blood circulation to prevent stasis.

King herbs

Huang Qi (Mi Zhi) and Tai Zi Shen serve as the dual Kings. Honey-processed Huang Qi is the foremost Qi tonic in TCM, powerfully supplementing Spleen and Lung Qi, raising Yang, and strengthening the body's defensive (Wei) Qi. Tai Zi Shen complements it by gently tonifying both Qi and Yin without generating excessive warmth, making it particularly appropriate for patients already debilitated by cancer treatment.

Deputy herbs

Bai Zhu (Chao) reinforces the Spleen-strengthening action of the Kings, particularly its ability to dry Dampness and support the transformation of food into Qi and Blood. Dang Gui adds the critical Blood-nourishing dimension, ensuring that the Qi generated by the Kings has a material substrate to work with. Together, the Kings and Deputies establish the classical pairing of Qi tonics with Blood tonics, reflecting the principle that Qi is the commander of Blood and Blood is the mother of Qi.

Assistant herbs

The assistants form three functional subgroups. The Kidney-nourishing group (Gou Qi Zi, Nu Zhen Zi, He Shou Wu, Huang Jing) replenishes Liver and Kidney Yin and Essence, addressing the deeper root of marrow deficiency. Shan Yao bridges the Spleen and Kidney strategies by tonifying both simultaneously. Ji Xue Teng serves as a reinforcing assistant that invigorates Blood, preventing stasis while promoting the generation of new blood cells. Zhi Mu is a restraining assistant that clears deficiency Heat and prevents the tonics from becoming too warming. Ban Xia (Fa) also plays a restraining role by preventing the rich tonics from causing Dampness or Stomach distress.

Envoy herbs

Chen Pi (Chao) serves as the envoy by regulating Qi flow in the Middle Burner, ensuring that all the heavy nourishing herbs are properly distributed rather than stagnating. Its aromatic, Qi-moving quality makes the entire formula more digestible and effective.

Notable synergies

Huang Qi paired with Dang Gui echoes the classical Dang Gui Bu Xue Tang combination, where strong Qi supplementation drives Blood generation. Nu Zhen Zi and Gou Qi Zi together form a well-known pairing for nourishing Liver-Kidney Yin, similar to their use in Er Zhi Wan. The combination of Ban Xia and Chen Pi prevents the many tonic herbs from causing stagnation, following the principle of 'supplementing without cloying' (补而不滞).

How to Prepare

Traditional preparation instructions for Sheng Bai Wan

Grind all herbs into fine powder and form into water pills (水泛丸). Take 6-9g per dose, two to three times daily, swallowed with warm water. The formula may also be prepared as a decoction by proportionally reducing the dosages and simmering in water for approximately 30-40 minutes.

Common Modifications

How practitioners adapt Sheng Bai Wan for specific situations

Added
E Jiao

9g, dissolved separately and stirred in, to powerfully nourish Blood and Essence

Shu Di Huang

12-15g, to enrich Yin and nourish Blood, supplementing Kidney Essence

When Blood deficiency is severe, E Jiao and Shu Di Huang are added to strongly enrich Yin and Blood. E Jiao is a classic Blood tonic that directly supplements the material basis for blood cell production.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Sheng Bai Wan should not be used or requires extra caution

Caution

Not suitable for cases of excess Heat or active febrile conditions, as the formula's warming and tonifying nature could aggravate Heat signs.

Caution

Use with caution in patients with Spleen-Stomach Dampness with significant food stagnation, as the rich, nourishing herbs (He Shou Wu, Huang Jing, Gou Qi Zi) may be difficult to digest and could worsen bloating.

Caution

He Shou Wu (Zhi) has been associated with rare cases of liver injury. Patients with pre-existing liver disease should use this formula with caution and under medical supervision.

Avoid

Not intended as a replacement for granulocyte colony-stimulating factor (G-CSF) in cases of severe leukopenia (Grade III or IV bone marrow suppression). Should be used as an adjunct, not a substitute, in critical white blood cell deficiency.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. He Shou Wu (Zhi), even in its processed form, has mild laxative properties that could theoretically stimulate the bowel and uterus. Zhi Mu is cold in nature and should be used cautiously. Ban Xia (Fa), while in its processed and safer form, is traditionally listed among herbs requiring caution during pregnancy. Overall, this formula should only be used during pregnancy under the direct supervision of a qualified practitioner who can weigh the risks and benefits for the individual case.

Breastfeeding

Limited safety data is available for use during breastfeeding. He Shou Wu (Zhi) is the primary herb of concern, as compounds from processed Polygonum multiflorum may transfer into breast milk, and its rare association with hepatotoxicity warrants caution. Zhi Mu, being cold in nature, could theoretically affect the quality of breast milk or cause digestive upset in nursing infants. If a breastfeeding mother requires this formula (for example, after cancer treatment), it should only be taken under close supervision of both a TCM practitioner and the infant's pediatrician.

Children

Sheng Bai Wan is not commonly prescribed for young children. Its primary indication — chemotherapy- or radiation-induced leukopenia — may occasionally apply to pediatric oncology patients, but dosing must be carefully adjusted by a qualified practitioner experienced in pediatric TCM. General guidelines suggest children aged 7-14 may take approximately half the adult dose, while children under 7 require further reduction (typically one-quarter to one-third of the adult dose). The formula contains He Shou Wu (Zhi), which has rare hepatotoxicity concerns that may be more significant in children with developing livers. Pediatric use should always be supervised by both a TCM practitioner and the child's oncologist.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Sheng Bai Wan

Chemotherapy agents: This formula is often used alongside chemotherapy. While the intent is supportive, Huang Qi (Astragalus) has immunomodulatory effects that could theoretically interact with immunosuppressive chemotherapy regimens. Timing of administration relative to chemotherapy cycles should be coordinated with the oncology team.

He Shou Wu (Zhi) and hepatotoxic drugs: Processed Polygonum multiflorum has been associated with rare hepatotoxicity. When combined with other potentially hepatotoxic medications (e.g., acetaminophen/paracetamol at high doses, certain statins, methotrexate), liver function should be monitored more closely.

Anticoagulant and antiplatelet medications: Dang Gui (Angelica sinensis) and Ji Xue Teng (Spatholobus) both have mild blood-activating properties and could theoretically potentiate the effects of warfarin, heparin, or antiplatelet drugs like aspirin and clopidogrel. Coagulation parameters should be monitored if used concurrently.

Antidiabetic medications: Huang Qi (Astragalus) may have hypoglycemic effects. Patients taking insulin or oral hypoglycemic agents should monitor blood glucose more closely when starting this formula.

Usage Guidance

Practical advice for getting the most out of Sheng Bai Wan

Best time to take

30 minutes after meals, 2-3 times daily, with warm water. Taking after meals reduces potential gastrointestinal discomfort from the rich tonifying herbs.

Typical duration

Often taken for 2-4 weeks per chemotherapy cycle, or continuously for 4-8 weeks during radiation therapy. Duration should be guided by blood count monitoring and reassessed by both the TCM practitioner and the oncologist.

Dietary advice

Favor warm, easily digestible, nutrient-dense foods that support Spleen function and Blood production: bone broth, lean meats (especially chicken and lamb), dark leafy greens, black sesame, walnuts, goji berries, red dates, and cooked root vegetables. Avoid cold, raw foods, iced drinks, and excessive dairy, as these can impair the Spleen's digestive function and reduce the formula's effectiveness. Limit greasy, fried, and overly rich foods that can generate Dampness. During cancer treatment, maintain adequate protein intake to support blood cell recovery. Small, frequent meals are preferable to large ones if appetite is poor.

Sheng Bai Wan originates from Modern clinical formula (现代经验方), published in the journal Shi Yong Zhong Xi Yi Jie He Za Zhi (实用中西医结合杂志), 1991 Modern era, late 20th century

Classical Texts

Key passages from the classical Chinese medical texts that first described Sheng Bai Wan and its clinical use

Sheng Bai Wan (升白丸) is a modern formula rather than a classical one, so it does not have direct quotations from ancient texts. However, the theoretical rationale draws on longstanding classical principles:

The concept of the Kidneys governing marrow and the Spleen governing Blood production is foundational. The Su Wen states: 「肾主骨生髓」 ("The Kidneys govern the bones and generate marrow"). Since white blood cells originate in bone marrow, this classical principle directly underpins the formula's strategy of tonifying the Kidneys to support marrow function and blood cell production.

The Ling Shu teaches: 「中焦受气取汁,变化而赤,是谓血」 ("The Middle Burner receives Qi and extracts fluids, which transform and become red — this is called Blood"). This principle supports the formula's emphasis on strengthening the Spleen (Middle Burner) as the source of Blood and Qi generation.

Historical Context

How Sheng Bai Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Sheng Bai Wan (升白丸, literally "Raise White [Blood Cell] Pill") is a modern TCM formula developed in contemporary Chinese hospitals to address a very modern clinical problem: leukopenia (low white blood cell counts) caused by chemotherapy, radiation therapy, or other medical treatments for cancer. It does not appear in any classical text and has no single attributed author in the traditional sense.

The formula represents an important trend in modern Chinese medicine: the creation of new formulas that combine classical TCM theory with the realities of modern disease. While classical TCM had no concept of "white blood cells," practitioners drew on the ancient understanding that the Kidneys govern marrow (which produces blood cells) and the Spleen governs Blood production to construct a formula targeting bone marrow recovery. The name itself — "Sheng Bai" (升白) — is a modern Chinese medical abbreviation meaning "raise the whites" (i.e., white blood cell count), reflecting its integration of Western diagnostic concepts with TCM therapeutic strategy.

This formula emerged alongside several related preparations (such as Qijiao Shengbai Capsule and various "Shengbai" decoctions) developed across different Chinese medical institutions since the late 20th century, all designed to support cancer patients undergoing bone marrow-suppressive treatments. It exemplifies how TCM has adapted to work in tandem with conventional oncology care in Chinese hospitals.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Sheng Bai Wan

1

Qijiaoshengbai Capsule for Leukopenia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2021)

Fu Y, Chen J, Li L, et al. Evidence-Based Complementary and Alternative Medicine, 2021, Article ID 1972981.

This systematic review analyzed 24 randomized controlled trials involving 2,692 participants with leukopenia. The meta-analysis found that Qijiao Shengbai Capsule (a related Shengbai-class formula) had positive effects on increasing white blood cell count, hemoglobin, platelets, and neutrophils, and improved bone marrow suppression rates and overall effectiveness rates when combined with conventional treatments. However, the authors noted that higher-quality, larger-scale trials are needed to confirm these findings.

Link
2

Qijiao Shengbai Capsule Alleviated Leukopenia by Interfering Leukotriene Pathway: Integrated Network Study of Multi-Omics (2024)

Ma C, Zhao J, Zheng G, et al. Phytomedicine, 2024, 128, 155529.

This preclinical study used multi-omics, network pharmacology, and a cyclophosphamide-induced leukopenia mouse model to investigate how a Shengbai-class formula works at the molecular level. The study identified 121 absorbed compounds and found that the formula significantly increased peripheral white blood cell counts after 15 days of treatment. Key pathways involved included the leukotriene pathway and MAPK signaling, with ALOX5 identified as a crucial therapeutic target.

PubMed
3

Mechanistic Study of Leukopenia Treatment by Qijiao Shengbai Capsule via the Bcl2/Bax/CASPASE3 Pathway (2024)

Jiang S, Wang P, Sun X, et al. Frontiers in Pharmacology, 2024, 15, 1451553.

This preclinical study combined network pharmacology, molecular docking, and multi-omics analysis in a mouse leukopenia model. The researchers found that the formula increases white blood cell counts by regulating the PI3K-Akt and MAPK signaling pathways, inhibiting mitochondrial apoptosis, and increasing CD4+ T cell counts in leukopenic mice. The results suggest the formula may improve immune function by regulating apoptotic proteins.

Link

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.