Gui Ling Gan Lu Yin

Cinnamon and Poria Sweet Dew Drink · 桂苓甘露飲

Also known as: Gui Ling Gan Lu San (桂苓甘露散), Gui Ling Bai Zhu San (桂苓白术散)

A classical formula designed for hot summer conditions where both Heat and Dampness accumulate in the body. It helps clear internal Heat, relieve thirst and irritability, and promote urination to drain excess Dampness. It is especially suited for summertime illness with fever, headache, digestive upset (vomiting and diarrhea), and reduced or dark urine.

Origin Huang Di Su Wen Xuan Ming Lun Fang (黄帝素问宣明论方) by Liu Wansu (刘完素) — Jīn dynasty, ~1172 CE
Composition 9 herbs
Hua Shi
King
Hua Shi
Shi Gao
Deputy
Shi Gao
Han Shui Shi
Deputy
Han Shui Shi
Fu Ling
Assistant
Fu Ling
Zhu Ling
Assistant
Zhu Ling
Ze Xie
Assistant
Ze Xie
Bai Zhu
Assistant
Bai Zhu
Rou Gui
Assistant
Rou Gui
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Gui Ling Gan Lu Yin is designed to correct these specific patterns.

Why Gui Ling Gan Lu Yin addresses this pattern

This is the primary pattern this formula addresses. In hot, humid summer conditions, Summerheat (a Yang pathogenic factor) combines with Dampness (a Yin pathogenic factor) to invade the body. The Summerheat generates internal Heat, causing fever, thirst, and irritability, while the Dampness obstructs Qi flow and impairs fluid metabolism, leading to reduced urination, heaviness, and digestive disturbance. The formula's three cold minerals (Hua Shi, Shi Gao, Han Shui Shi) powerfully clear the Summerheat, while the Wu Ling San component (Fu Ling, Zhu Ling, Ze Xie, Bai Zhu, Rou Gui) transforms Qi and drains Dampness through urination. Gan Cao and Hua Shi together (Liu Yi San) specifically target Summerheat resolution. This formula is particularly suited when the Heat component is more pronounced than the Dampness, or when both are equally severe.

A practitioner would look for one or more of these signs

Fever

Fever due to Summerheat invasion

Headaches

Headache with sensation of heaviness

Excessive Thirst

Intense thirst with desire to drink

Irritability

Restlessness and irritability from Heat

Difficult Urination

Scanty, dark, or painful urination

Diarrhea

Watery diarrhea or cholera-like vomiting and diarrhea

Nausea Or Vomiting

Vomiting with simultaneous diarrhea (sudden turmoil disorder)

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Gui Ling Gan Lu Yin when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM understands acute gastroenteritis occurring in summer as a case where Summerheat and Dampness invade the Stomach and Intestines, disrupting their normal ascending and descending functions. The Stomach's job is to send food downward, while the Spleen sends refined nutrients upward. When Damp-Heat clogs the middle burner, the Stomach rebels upward (causing vomiting) and the Spleen fails to transform fluids properly (causing diarrhea). This simultaneous vomiting and diarrhea is what classical texts call 'sudden turmoil disorder' (huo luan). The Damp-Heat also blocks Bladder Qi transformation, resulting in reduced urination even while fluids are lost through the bowels.

Why Gui Ling Gan Lu Yin Helps

Gui Ling Gan Lu Yin addresses this condition from multiple angles. The three cold mineral substances (Hua Shi, Shi Gao, Han Shui Shi) directly clear the Heat from the Stomach and Intestines that is driving the vomiting and diarrhea. The diuretic herbs (Fu Ling, Zhu Ling, Ze Xie) re-establish proper fluid pathways by promoting urination, which diverts excess Dampness away from the gut. Bai Zhu strengthens the Spleen to restore its transforming function, while Rou Gui warms the Bladder to ensure fluids flow in the right direction. By restoring normal ascending and descending functions and draining Dampness through the urine, the formula resolves the 'sudden turmoil' pattern effectively.

Also commonly used for

Cholera

Sudden turmoil disorder with simultaneous vomiting and diarrhea

Urinary Tract Infection

Damp-Heat type with painful, scanty, dark urine

Diarrhea

Acute watery diarrhea in summer due to Damp-Heat

Edema

Edema with accompanying Heat signs

Fever

Summer febrile disease with Dampness

What This Formula Does

Every TCM formula has a specific set of actions — here's what Gui Ling Gan Lu Yin does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Gui Ling Gan Lu Yin is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Gui Ling Gan Lu Yin performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Gui Ling Gan Lu Yin works at the root level.

Gui Ling Gan Lu Yin addresses a condition where external Summer-Heat invades the body and combines with internal Dampness, creating a complex pattern of Heat and stagnant fluids. In TCM theory, the intense heat of summer can overwhelm the body's ability to regulate its temperature and fluid metabolism. When a person is exposed to Summer-Heat and then drinks large amounts of cold fluids to quench their thirst, the Spleen and Stomach (the digestive organs responsible for transforming and transporting fluids) become overwhelmed. The fluids accumulate internally rather than being properly distributed and excreted.

This creates a dual pathology: Heat from the Summer-Heat lodges in the Qi level, producing fever, irritability, and intense thirst, while stagnant water and Dampness obstruct the normal flow of Qi, blocking urination and disrupting the Stomach's descending function. When the Stomach Qi rebels upward, vomiting occurs; when turbid Dampness pours downward, diarrhea results. In severe cases, both happen simultaneously, a condition classical texts call "sudden turmoil disorder" (霍乱 huo luan). The Bladder's Qi transformation function is impaired, so urine output decreases even as the person keeps drinking, creating a vicious cycle of fluid accumulation.

The formula works because it simultaneously addresses both the Heat and the Dampness. It clears Summer-Heat from the Qi level while opening the waterways to drain accumulated fluids through urination, restoring the normal ascending-descending movement of Qi in the middle burner. The small amount of warming Cinnamon ensures that the cold minerals do not freeze the Qi mechanism, keeping the body's fluid transformation active even while clearing Heat.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bland and sweet with a cool, mineral quality — bland to drain Dampness through urination, sweet to protect the Stomach, and mineral-cool to clear Summer-Heat.

Channels Entered

Stomach Bladder Spleen Lung

Ingredients

9 herbs

The herbs that make up Gui Ling Gan Lu Yin, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Hua Shi

Hua Shi

Talcum

Dosage 12 - 18g
Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Stomach, Urinary Bladder
Preparation Wrap in cloth when decocting (包煎)

Role in Gui Ling Gan Lu Yin

The principal herb in the formula, used in the largest dose. Hua Shi clears Summerheat and drains Damp-Heat downward through the urine, directly addressing both the Heat and Dampness that are the core pathogenic factors in this pattern.
Deputies — Assists and enhances the King
Shi Gao

Shi Gao

Gypsum

Dosage 9 - 15g
Temperature Cold
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Stomach
Preparation Crush and decoct first 20-30 minutes (先煎)

Role in Gui Ling Gan Lu Yin

Clears Heat and drains Fire from the Qi level, powerfully relieving fever, thirst, and irritability. Works alongside Hua Shi and Han Shui Shi as one of the 'three stones' (san shi) to clear Heat from the six bowels.
Han Shui Shi

Han Shui Shi

Calcite / Red Gypsum

Dosage 9 - 15g
Temperature Cold
Taste Acrid / Pungent (辛 xīn), Salty (咸 xián)
Organ Affinity Heart, Stomach, Kidneys
Preparation Crush and decoct first (先煎)

Role in Gui Ling Gan Lu Yin

Clears Heat and drains Fire, reinforcing the cooling power of Shi Gao. Together with Shi Gao and Hua Shi, it forms the 'three stones' grouping that provides the formula's strong Heat-clearing action.
Assistants — Supports or moderates other herbs
Fu Ling

Fu Ling

Poria

Dosage 9 - 15g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys

Role in Gui Ling Gan Lu Yin

Strengthens the Spleen and promotes urination to drain Dampness. As part of the Wu Ling San component within this formula, Fu Ling supports the transformation and transportation of fluids.
Zhu Ling

Zhu Ling

Polyporus

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Kidneys, Urinary Bladder

Role in Gui Ling Gan Lu Yin

Promotes urination and drains Dampness, complementing Fu Ling and Ze Xie. Together these diuretic herbs ensure Dampness is expelled through the urinary pathway.
Ze Xie

Ze Xie

Water plantain rhizome

Dosage 6 - 10g
Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Kidneys, Urinary Bladder

Role in Gui Ling Gan Lu Yin

Promotes urination and drains Dampness from the lower burner, directly reaching the Kidney and Bladder to facilitate fluid metabolism.
Bai Zhu

Bai Zhu

White Atractylodes rhizome

Dosage 3 - 6g
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach

Role in Gui Ling Gan Lu Yin

Strengthens the Spleen and dries Dampness, supporting the body's ability to transform and transport fluids. Helps prevent Dampness from accumulating again by supporting the root of fluid metabolism.
Rou Gui

Rou Gui

Cinnamon bark

Dosage 1.5 - 3g
Temperature Hot
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Liver, Spleen, Kidneys
Preparation Added in last 5 minutes of decoction (后下)

Role in Gui Ling Gan Lu Yin

Warms Yang and promotes Qi transformation to assist the Bladder in transforming fluids. Its warming nature helps counterbalance the large amount of cold minerals in the formula and prevents the cold herbs from congealing Dampness. A small dose is used strategically.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 6 - 10g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Gui Ling Gan Lu Yin

Harmonizes the actions of the diverse formula ingredients and protects the Middle Burner. Together with Hua Shi it forms the Liu Yi San (Six-to-One Powder) within this formula, clearing Summerheat and augmenting Qi.

Why This Combination Works

How the herbs in Gui Ling Gan Lu Yin complement each other

Overall strategy

This formula is designed to clear Summerheat and resolve internal Dampness simultaneously, using the principle of combining cold mineral substances with warm Qi-transforming and Dampness-draining herbs. It ingeniously combines two classical formulas (Wu Ling San and Liu Yi San) with additional Heat-clearing minerals to address the full complexity of Summerheat-Dampness patterns.

King herbs

Hua Shi (Talcum) serves as the King in the largest dose, because it uniquely addresses both pathogenic factors at once: it clears Summerheat and drains Damp-Heat downward through the urine. Its sweet, bland, and cold nature makes it ideally suited for this dual action, channeling Heat out via the urinary tract.

Deputy herbs

Shi Gao (Gypsum) and Han Shui Shi (Calcitum) together with Hua Shi form the 'three stones' (san shi) grouping. Shi Gao is the strongest Qi-level Heat-clearing mineral, powerfully relieving high fever, intense thirst, and irritability. Han Shui Shi reinforces this cooling action and also clears Heat from the six bowels. The three stones together provide the formula's core Heat-clearing power.

Assistant herbs

Four herbs form the Wu Ling San component: Fu Ling, Zhu Ling, Ze Xie, and Bai Zhu all work to promote urination and drain Dampness (reinforcing assistants). Fu Ling and Bai Zhu additionally strengthen the Spleen to support the root of fluid metabolism. Rou Gui serves as a restraining assistant: its warm nature activates Bladder Qi transformation so that fluids can be properly metabolized, and it prevents the large quantity of cold mineral herbs from congealing and trapping the very Dampness the formula aims to expel.

Envoy herbs

Gan Cao (honey-prepared) harmonizes all the ingredients and protects the Stomach and Spleen from the harsh mineral substances. It pairs with Hua Shi to form Liu Yi San (Six-to-One Powder), a classical Summerheat-clearing combination in its own right.

Notable synergies

The pairing of Hua Shi with Gan Cao (Liu Yi San) is the formula's backbone for clearing Summerheat and promoting urination. The Wu Ling San group (Fu Ling, Zhu Ling, Ze Xie, Bai Zhu, Rou Gui) provides warm Qi transformation and Dampness drainage. The three cold stones clear Heat from inside, while the small amount of Rou Gui prevents the cold from freezing Dampness in place. This balancing act between cold clearing and warm transforming is the formula's signature design.

How to Prepare

Traditional preparation instructions for Gui Ling Gan Lu Yin

The original text instructs that all ingredients should be ground into a fine powder. Take 9g (approximately 3 qian) of the powder per dose, dissolved in warm water or fresh water. Ginger decoction (Sheng Jiang Tang) can also be used to dissolve the powder for enhanced effect. For children, the dose is reduced to approximately 3g (1 qian) per serving.

Alternatively, the formula can be prepared as a decoction with proportionally reduced dosages. When preparing as a decoction, the mineral ingredients (Hua Shi, Shi Gao, Han Shui Shi) should be decocted first for 20-30 minutes before adding the remaining herbs.

Common Modifications

How practitioners adapt Gui Ling Gan Lu Yin for specific situations

Added
Zhi Mu

10g, to enhance Heat-clearing and generate fluids

When the Summerheat is severe with high fever and intense thirst, adding Zhi Mu reinforces the Qi-level Heat-clearing action of Shi Gao and further generates body fluids to relieve thirst.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Gui Ling Gan Lu Yin should not be used or requires extra caution

Avoid

Yin Deficiency with Heat signs (dry mouth, night sweats, red tongue with little coating). The cold, draining minerals and diuretic herbs in this formula can further deplete Yin fluids.

Avoid

Cold-Dampness without Heat. This formula is designed for Summer-Heat combined with Dampness. If there is only Cold-Dampness without any Heat component, the cold-natured minerals (Shi Gao, Han Shui Shi, Hua Shi) will worsen the condition.

Caution

Spleen and Stomach Yang Deficiency with cold signs (cold limbs, watery stools, pale tongue). The large dose of cold minerals may further damage Yang Qi.

Caution

Excessive sweating or severe fluid depletion. The diuretic action of multiple water-draining herbs (Fu Ling, Zhu Ling, Ze Xie, Hua Shi) can worsen dehydration.

Caution

Chronic, debilitated patients with Qi Deficiency. The formula is designed for acute Summer-Heat illness in relatively robust individuals, not for prolonged tonification.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Hua Shi (Talcum) and Ze Xie (Alisma) are strongly draining and diuretic, which may deplete fluids needed during pregnancy. Han Shui Shi (Glauberite) and Shi Gao (Gypsum) are cold in nature and may adversely affect the Spleen Yang, which is already under strain during pregnancy. Zhu Ling (Polyporus) adds further diuretic action. While none of these herbs are classically listed as abortifacient, the overall strongly draining and cold nature of this formula makes it unsuitable for routine use in pregnant women. If Summer-Heat illness occurs during pregnancy, a qualified practitioner should carefully weigh the risks and modify the formula accordingly.

Breastfeeding

No specific classical prohibitions exist for use during breastfeeding. However, the formula's strongly draining and diuretic nature (from Hua Shi, Ze Xie, Fu Ling, and Zhu Ling) could theoretically reduce fluid volume and potentially affect milk production. The cold minerals (Shi Gao, Han Shui Shi) may also be a concern as their effect on breast milk composition is unknown. Gan Cao (Licorice) contains glycyrrhizin which can pass into breast milk. This formula is intended for short-term acute use in Summer-Heat conditions, so brief use under practitioner supervision is reasonable, but prolonged use should be avoided during lactation.

Children

Classical texts specifically note that this formula can be used for children experiencing summer vomiting, diarrhea, and fright Wind (小儿吐泻、惊风). Dosages should be reduced significantly based on age and body weight, typically to one-third to one-half of the adult dose for children over 6 years, and one-quarter for younger children. The formula should be given in smaller, more frequent doses rather than large single doses. Because the formula contains strongly draining minerals and diuretic herbs, careful monitoring of fluid intake and hydration status is essential in pediatric use. For infants under 1 year, this formula is generally not recommended without close practitioner supervision.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Gui Ling Gan Lu Yin

Gan Cao (Licorice Root): Glycyrrhizin in Gan Cao can cause pseudoaldosteronism (sodium retention, potassium loss, elevated blood pressure). It may interact with antihypertensive medications, diuretics (especially potassium-depleting types like thiazides and loop diuretics, compounding potassium loss), corticosteroids (additive mineralocorticoid effects), and digoxin/cardiac glycosides (hypokalemia increases toxicity risk).

Diuretic herbs (Fu Ling, Zhu Ling, Ze Xie, Hua Shi): The combined diuretic effect of these four herbs may potentiate pharmaceutical diuretics, increasing the risk of dehydration and electrolyte imbalance. Caution is warranted when co-administered with thiazide or loop diuretics. Ze Xie (Alisma) has demonstrated lipid-lowering effects in some studies and may theoretically interact with statin medications.

Mineral herbs (Shi Gao, Han Shui Shi, Hua Shi): These calcium- and sulfate-containing minerals may interfere with the absorption of tetracycline antibiotics, fluoroquinolones, and bisphosphonates if taken simultaneously. A two-hour separation between doses is advisable.

Usage Guidance

Practical advice for getting the most out of Gui Ling Gan Lu Yin

Best time to take

Between meals, 2–3 times daily. In acute Summer-Heat illness with vomiting and diarrhea, small frequent doses throughout the day are preferred.

Typical duration

Acute use: 1–5 days, discontinued once symptoms resolve. Not intended for long-term use.

Dietary advice

While taking this formula, avoid greasy, fried, and heavy foods that generate Dampness and burden the Spleen. Cold, raw foods and excessive iced drinks should also be avoided, as they can impair the Spleen's Qi transformation despite the formula's cooling nature. Light, easily digestible foods such as rice porridge (congee), mung bean soup, and winter melon are supportive. Avoid alcohol and spicy, hot foods that may intensify internal Heat. Adequate fluid intake with warm or room-temperature water is important to support urination and prevent dehydration, especially during summer illness with vomiting and diarrhea.

Gui Ling Gan Lu Yin originates from Huang Di Su Wen Xuan Ming Lun Fang (黄帝素问宣明论方) by Liu Wansu (刘完素) Jīn dynasty, ~1172 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Gui Ling Gan Lu Yin and its clinical use

Liu Wansu (刘完素), Huang Di Su Wen Xuan Ming Lun Fang (黄帝素问宣明论方):

Original indication: 「治中暑受湿,引饮过多,头痛烦渴,湿热小便秘」
"Treats Summer-Heat with Dampness, excessive fluid intake, headache with irritability and thirst, Damp-Heat with urinary difficulty."

Classical commentary from Tui Si Ji Lei Fang Ge Zhu (退思集类方歌注):

The formula is described as treating 「中暑受湿,引饮过多,头痛烦渴,湿热小便秘」 — a condition where Summer-Heat and Dampness lodge internally, the person drinks excessively but cannot properly metabolize the fluids, leading to headache, irritability, thirst, and urinary difficulty.

Later commentary explains the structural logic:

「方由六一散合五苓散加石膏、寒水石而成」
"The formula is constructed from Liu Yi San combined with Wu Ling San, plus Shi Gao and Han Shui Shi." This commentary highlights how Liu Wansu synthesized two classical foundations: the Summer-Heat clearing power of Liu Yi San with the water-transforming capacity of Wu Ling San, adding powerful mineral Heat-clearers to address the intensity of Summer-Heat pathology.

Historical Context

How Gui Ling Gan Lu Yin evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Gui Ling Gan Lu Yin was created by Liu Wansu (刘完素, c. 1120–1200), one of the four great masters of the Jin-Yuan medical era and founder of the "Cooling and Cold" school (寒凉派). It was first recorded in his work Huang Di Su Wen Xuan Ming Lun Fang (黄帝素问宣明论方, "Discussion Illuminating the Yellow Emperor's Basic Questions"). Liu Wansu was famous for his theory that "the six Qi can all transform into Fire" and emphasized clearing Heat as a primary therapeutic strategy, which is reflected in this formula's heavy use of cold minerals.

The formula is a masterful synthesis of two pre-existing classical prescriptions: Liu Yi San (六一散, "Six-to-One Powder," also attributed to Liu Wansu) composed of Hua Shi and Gan Cao for clearing Summer-Heat, and Zhang Zhongjing's Wu Ling San (五苓散, from the Shang Han Lun) for transforming Bladder Qi and promoting urination. To these Liu added Shi Gao (Gypsum) and Han Shui Shi (Glauberite) to powerfully clear Heat from the Qi level. This layered construction shows Liu Wansu's approach of building on classical foundations while intensifying the Heat-clearing strategy.

Several variant compositions exist under the same name in different texts. The Shang Han Zhi Ge (伤寒直格) and Wei Sheng Bao Jian (卫生宝鉴) record versions that include additional aromatic herbs like Huo Xiang (Agastache) and Mu Xiang (Aucklandia), along with Ren Shen (Ginseng), broadening the formula's scope to include more severe cases with Qi Deficiency and turbid Dampness. The core principle, however, remains consistent across versions: clearing Summer-Heat while draining Dampness through urination.