Chai Hu Qing Gan Tang

Bupleurum Decoction to Clear the Liver · 柴胡清肝湯

Also known as: Bupleurum and Rehmannia Combination, Chai Hu Qing Gan San

A classical formula originally designed to treat early-stage boils and abscesses at the temples, now widely used for any condition involving Liver Fire with toxic swellings such as swollen lymph nodes, chronic tonsillitis, inflammatory skin conditions, and breast inflammation. It works by clearing Heat from the Liver, resolving toxicity, nourishing Blood, and dispersing nodules.

Origin Wai Ke Zheng Zong (外科正宗, Orthodox Manual of External Medicine) by Chen Shigong (陈实功) — Míng dynasty, 1617 CE
Composition 12 herbs
Chai Hu
King
Chai Hu
Shu Di huang
King
Shu Di huang
Dang Gui
Deputy
Dang Gui
Bai Shao
Deputy
Bai Shao
Chuan Xiong
Deputy
Chuan Xiong
Huang Qin
Assistant
Huang Qin
Zhi Zi
Assistant
Zhi Zi
Lian Qiao
Assistant
Lian Qiao
+4
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Chai Hu Qing Gan Tang is designed to correct these specific patterns.

Why Chai Hu Qing Gan Tang addresses this pattern

When the Liver's Qi becomes constrained, often due to emotional stress or frustration, the stagnation can transform into Fire over time. This Liver Fire blazes upward along the Liver and Gallbladder channels, affecting the head, eyes, ears, and temples. In this formula, Chai Hu spreads the constrained Liver Qi while Huang Qin and Shan Zhi Zi directly drain the accumulated Fire. Sheng Di Huang cools the Blood that has been heated, while the Si Wu Tang foundation (Dang Gui, Bai Shao, Chuan Xiong, Sheng Di Huang) nourishes the Blood and Yin that Fire tends to consume. This two-pronged approach of clearing Fire and nourishing Blood makes the formula particularly suited for Liver Fire patterns where the Fire has already begun to damage Yin and Blood.

A practitioner would look for one or more of these signs

Irritability

Restlessness and easy anger from Liver Fire flaring

Headaches

Particularly at the temples along the Gallbladder channel

Red Eyes

Redness and swelling of the eyes from upward-blazing Fire

Bitter Taste In The Mouth

Bitter taste in the mouth, a hallmark of Liver-Gallbladder Heat

Tinnitus

Ringing or pain in the ears from Fire along the Shaoyang channel

Dry Mouth

Dryness from Heat consuming fluids

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Chai Hu Qing Gan Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM understands swollen lymph nodes in the neck as a condition where Heat, toxin, and Phlegm accumulate along the Liver and Gallbladder channels, which traverse the lateral neck. When Liver Qi becomes constrained and transforms into Fire, this Heat can congeal fluids into Phlegm and combine with toxin to form hard, swollen nodules. The condition often arises in people prone to emotional frustration or anger, or in those with an underlying Blood deficiency that fails to adequately nourish and cool the Liver. The Shaoyang (Gallbladder) channel is particularly significant here, as it runs directly through the area where cervical lymph nodes are found.

Why Chai Hu Qing Gan Tang Helps

Chai Hu Qing Gan Tang targets this condition from multiple angles. Chai Hu and Huang Qin together clear Heat from the Shaoyang channel that traverses the neck. Lian Qiao and Niu Bang Zi directly resolve toxicity and disperse the accumulations that form as nodules. Tian Hua Fen helps reduce swelling by clearing Heat and generating fluids. Meanwhile, the Blood-nourishing herbs (Dang Gui, Bai Shao, Sheng Di Huang, Chuan Xiong) address the underlying Blood deficiency that allowed the condition to develop and support the body's healing capacity. Gan Cao Jie specifically targets nodular formations.

Also commonly used for

Tonsillitis

Chronic or recurrent tonsillitis with sore throat and Heat signs

Otitis Media

Middle ear infections with Heat signs along the Shaoyang channel

Viral Conjunctivitis

Red, swollen, painful eyes from Liver Fire flaring upward

Eczema

Skin eruptions with redness, itching, and Heat from Liver-Gallbladder Damp-Heat

Headaches

Temporal headaches from Liver-Gallbladder channel Heat

Skin Abscess

Early-stage boils and abscesses, particularly on the temples (the original indication)

Scrofula

Cervical lymph node nodules from chronic Heat-toxin accumulation

What This Formula Does

Every TCM formula has a specific set of actions — here's what Chai Hu Qing Gan Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Chai Hu Qing Gan Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Chai Hu Qing Gan Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Chai Hu Qing Gan Tang works at the root level.

This formula addresses a pattern where Heat accumulates in the Liver, Gallbladder, and San Jiao (Triple Burner) channels. The Liver prefers smooth, unobstructed movement of Qi. When emotional stress, poor diet, or external Wind-Heat pathogens disturb the Liver, Qi stagnation can develop and transform into Heat over time. This Liver-Gallbladder Heat then rises along the channel pathways toward the head, ears, eyes, and throat, producing symptoms such as headache, tinnitus, red painful eyes, sore throat, and chronic tonsillitis. When this Heat becomes more severe, it can condense into 'Fire Toxin,' manifesting as swollen lymph nodes, boils, abscesses (especially around the temples, ears, and neck), and inflamed skin conditions like eczema.

Because the Liver stores Blood, prolonged Heat in the Liver channel also scorches and consumes the Blood, leading to dry, itchy, or darkened skin and a tendency toward irritability and restlessness. In children, this pattern often presents as what was classically called a 'scrofulous constitution' (腺病质): the child tends to be thin, nervous, prone to skin rashes, swollen tonsils, and frequent upper respiratory infections. The tongue is typically red with a yellow coating, and the pulse is wiry (indicating Liver involvement) and rapid (indicating Heat).

The formula works by simultaneously clearing the excess Heat from the Liver and Gallbladder channels, dispersing Wind-Heat from the surface, resolving toxic swelling, and nourishing Blood to prevent further damage from the Heat. By addressing both the root (Liver-channel Heat) and the branches (toxic swelling, Wind-Heat symptoms), it restores balance to the Liver system and calms the inflammatory processes along its pathways.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly bitter and acrid with a sweet undertone — bitter to clear Heat and drain Fire, acrid to disperse Wind and move stagnation, sweet to nourish Blood and harmonize.

Target Organs

Liver Gallbladder San Jiao (Triple Burner)

Channels Entered

Ingredients

12 herbs

The herbs that make up Chai Hu Qing Gan Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Chai Hu

Chai Hu

Bupleurum roots

Dosage 3 - 6g
Temperature Cool
Taste Bitter
Organ Affinity Gallbladder, Liver

Role in Chai Hu Qing Gan Tang

Spreads Liver Qi, clears Heat from the Liver and Gallbladder channels, and vents pathogenic factors outward from the Shaoyang level. As the lead herb, it addresses the root mechanism of Liver Fire and constraint that drives the formation of toxic swellings.
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 3 - 6g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in Chai Hu Qing Gan Tang

Cools the Blood and nourishes Yin to counteract the drying effects of Liver Fire. Works alongside Chai Hu to address both the Heat and the underlying Blood deficiency that allows Fire to flare.
Deputies — Assists and enhances the King
Dang Gui

Dang Gui

Dong quai

Dosage 3 - 5g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Heart, Liver, Spleen

Role in Chai Hu Qing Gan Tang

Nourishes and invigorates the Blood, supporting the Liver's Blood-storing function. Prevents the Heat-clearing herbs from further damaging Yin and Blood, and promotes healing of sores by ensuring adequate Blood circulation.
Bai Shao

Bai Shao

White peony roots

Dosage 3 - 5g
Temperature Neutral
Taste Bitter, Sour
Organ Affinity Liver, Spleen

Role in Chai Hu Qing Gan Tang

Nourishes Liver Blood and restrains Liver Yang, softening the Liver to prevent Fire from flaring further. Pairs with Dang Gui to form the Blood-nourishing foundation of the formula.
Chuan Xiong

Chuan Xiong

Szechuan lovage roots

Dosage 3 - 5g
Temperature Warm
Taste Pungent
Organ Affinity Gallbladder, Liver, Pericardium

Role in Chai Hu Qing Gan Tang

Moves Blood and promotes Qi circulation, preventing Blood stasis that could worsen swelling and nodulation. Directs the Blood-nourishing herbs into active circulation and alleviates pain.
Assistants — Supports or moderates other herbs
Huang Qin

Huang Qin

Baikal skullcap roots

Dosage 3 - 5g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Large Intestine, Lungs, Small Intestine, Spleen

Role in Chai Hu Qing Gan Tang

Clears Heat and drains Fire from the Liver and Gallbladder, reinforcing the Heat-clearing action. Its bitter-cold nature directly purges the accumulated Fire toxin contributing to abscess formation.
Zhi Zi

Zhi Zi

Cape jasmine fruits

Dosage 3 - 5g
Temperature Cold
Taste Bitter
Organ Affinity Gallbladder, Heart, Lungs, Sanjiao, San Jiao (Triple Burner)

Role in Chai Hu Qing Gan Tang

Clears Heat from all three Burners and drains Damp-Heat downward through the urine. Particularly effective at clearing Liver Fire and resolving irritability.
Lian Qiao

Lian Qiao

Forsythia fruits

Dosage 3 - 5g
Temperature Cool
Taste Bitter
Organ Affinity Heart, Lungs, Small Intestine

Role in Chai Hu Qing Gan Tang

Clears Heat, resolves toxicity, and disperses nodules and swellings. Particularly important for the formula's surgical application in treating early-stage boils and abscesses on the temples.
Tian Hua Fen

Tian Hua Fen

Snake gourd roots

Dosage 3 - 5g
Temperature Cold
Taste Bitter, Sour, Sweet
Organ Affinity Stomach, Lungs

Role in Chai Hu Qing Gan Tang

Clears Heat, generates fluids, and reduces swelling. Helps counteract the fluid-damaging effects of Fire and supports the resolution of abscesses by draining pus.
Niu Bang Zi

Niu Bang Zi

Greater burdock fruits

Dosage 3 - 5g
Temperature Cold
Taste Bitter, Pungent
Organ Affinity Lungs, Stomach

Role in Chai Hu Qing Gan Tang

Disperses Wind-Heat, clears toxicity, benefits the throat, and promotes the eruption of skin rashes. Addresses the exterior Wind-Heat component and helps vent pathogenic Heat outward through the skin.
Fang Feng

Fang Feng

Saposhnikovia roots

Dosage 3 - 5g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Urinary Bladder, Liver, Spleen

Role in Chai Hu Qing Gan Tang

Expels Wind and releases the exterior, helping vent pathogenic Heat outward. Its gentle dispersing nature complements the interior Heat-clearing herbs by addressing any residual external pathogenic factor.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Liquorice

Dosage 3 - 5g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Chai Hu Qing Gan Tang

Harmonizes all the herbs in the formula, clears Heat, and resolves toxicity. The use of Gan Cao Jie (the node section of licorice root) specifically enhances its ability to clear toxins and guide the formula's action toward dispersing nodules.

Why This Combination Works

How the herbs in Chai Hu Qing Gan Tang complement each other

Overall strategy

This formula addresses a pattern where Liver Fire and Blood deficiency combine to produce toxic swellings, particularly in the head and neck region. The prescription strategy simultaneously clears Liver Fire, resolves toxicity, nourishes Blood, and disperses nodules, ensuring that purging Heat does not further injure the Blood and Yin that are already deficient.

King herbs

Chai Hu leads the formula by spreading Liver Qi and clearing Heat from the Liver and Gallbladder channels, directly addressing the Qi stagnation that generates Fire. Sheng Di Huang (raw Rehmannia) cools the Blood and nourishes Yin, tackling the root deficiency that allows Fire to rage. Together, these two herbs establish the formula's dual action of clearing Fire while protecting Yin and Blood.

Deputy herbs

Dang Gui and Bai Shao nourish Liver Blood, preventing the cold and bitter Heat-clearing herbs from further depleting the body. Chuan Xiong invigorates Blood circulation and moves Qi, ensuring that stagnation does not worsen into more severe nodulation. Together with Sheng Di Huang, these three herbs form the core of Si Wu Tang (Four Substances Decoction), the classical Blood-nourishing formula, embedded within the prescription to support healing from the inside.

Assistant herbs

Huang Qin and Shan Zhi Zi (reinforcing assistants) amplify the Heat-clearing action, directly draining Liver-Gallbladder Fire. Lian Qiao and Niu Bang Zi (counteracting assistants) clear toxicity and disperse swellings, addressing the external manifestation of abscesses and nodules. Tian Hua Fen clears Heat and generates fluids, while also helping resolve swellings. Fang Feng gently disperses Wind from the exterior, ensuring that any residual external pathogenic factor is vented outward rather than trapped inside.

Envoy herbs

Gan Cao Jie (the node section of licorice) harmonizes the formula's diverse actions and has a particular affinity for clearing toxicity and dispersing nodules, directing the formula's overall action toward the resolution of toxic swellings.

Notable synergies

The embedded Si Wu Tang (Dang Gui, Bai Shao, Chuan Xiong, Sheng Di Huang) paired with the Heat-clearing herbs (Huang Qin, Shan Zhi Zi) mirrors the structure of Wen Qing Yin, a formula for clearing chronic Heat while nourishing Blood. This pairing allows aggressive Heat-clearing without depleting the body. The Chai Hu and Huang Qin pair echoes the core of Xiao Chai Hu Tang, working together to harmonize the Shaoyang and clear Half-Exterior Half-Interior Heat. Lian Qiao combined with Niu Bang Zi creates a potent toxin-resolving and swelling-dispersing duo particularly effective for head and neck conditions.

How to Prepare

Traditional preparation instructions for Chai Hu Qing Gan Tang

Add all 12 herbs to approximately 400ml (2 bowls) of water. Bring to a boil, then reduce heat and simmer until approximately 320ml (about 80% of original volume) remains. Strain and take warm on an empty stomach or between meals. In the original text, this is prepared as a single daily dose.

Common Modifications

How practitioners adapt Chai Hu Qing Gan Tang for specific situations

Added
Jin Yin Hua

9 - 15g, strongly clears Heat and resolves toxicity

Pu Gong Ying

9 - 15g, clears Heat toxin and reduces swelling, especially for breast and skin abscesses

When the abscess has progressed to form pus, the Heat-toxin resolving capacity of the base formula needs reinforcement. Jin Yin Hua and Pu Gong Ying are classic toxin-clearing herbs that strengthen the formula's ability to drain pus and reduce inflammation.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Chai Hu Qing Gan Tang should not be used or requires extra caution

Caution

Spleen and Stomach deficiency Cold: the formula is predominantly cooling and bitter, containing multiple cold herbs (Huang Qin, Shan Zhi Zi, Sheng Di Huang, Lian Qiao). Patients with weak digestion, loose stools, poor appetite, or cold constitution should not use this formula without significant modification.

Caution

Yin deficiency with no real Heat: while the formula contains Blood-nourishing herbs, its strong Heat-clearing action can further deplete Yin and fluids if true Heat is absent. It should not be used for patterns of pure Yin deficiency with empty-Heat signs.

Caution

Pregnancy: the formula contains herbs that move Blood (Chuan Xiong, Dang Gui, Chi Shao) and clear Heat strongly. Use during pregnancy requires careful practitioner supervision.

Caution

Prolonged use without reassessment: the formula's bitter-cold nature can injure the Stomach and Spleen over time. It should not be taken long-term without periodic evaluation by a qualified practitioner.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. The formula contains Chuan Xiong (Ligusticum) and Dang Gui (Angelica sinensis), both of which activate Blood circulation and could theoretically stimulate uterine activity. Chi Shao (Red Peony) also moves Blood and cools it. Additionally, Niu Bang Zi (Burdock seed) has a slippery, descending quality. While none of these herbs are classified as strictly prohibited in pregnancy, the overall Blood-moving and strongly cooling character of this formula makes it unsuitable for routine use during pregnancy. If clinically necessary, a qualified practitioner should supervise use, adjust dosages, and monitor carefully.

Breastfeeding

Limited safety data exists for this formula during breastfeeding. The formula contains bitter-cold herbs (Huang Qin, Shan Zhi Zi, Lian Qiao) whose constituents may transfer to breast milk in small amounts and could potentially cause loose stools or decreased appetite in the nursing infant. Sheng Di Huang (raw Rehmannia) is cold in nature and may also affect the infant's digestion indirectly. If a breastfeeding mother requires this formula for an acute Liver-Heat condition, short-term use under practitioner guidance is likely acceptable, but the infant should be monitored for digestive changes. Prolonged use is not recommended without professional supervision.

Children

Chai Hu Qing Gan Tang is historically one of the most important pediatric formulas, particularly in the Japanese Kampo tradition where it is a primary prescription for children with a 'scrofulous' or 'detoxification' constitution. It is commonly used for children who are nervous, irritable, prone to swollen tonsils, chronic ear infections, eczema, and skin rashes. Dosage should be adjusted by age and body weight. As a general guideline: infants under 2 years typically receive one-quarter to one-third of the adult dose; children ages 2-6 receive one-third to one-half; children ages 6-12 receive one-half to two-thirds. The Tsumura granule formulation (Japan) provides specific pediatric dosing: typically 2.5g daily for small children, increased toward 5-7.5g daily for older children. Because the formula is bitter-cold in nature, prolonged use may affect appetite or digestion in children with already weak Spleen-Stomach function. If the child develops loose stools or decreased appetite, the dose should be reduced or the formula discontinued. Practitioners often combine it with mild digestive support if used over several weeks.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Chai Hu Qing Gan Tang

Gan Cao (Licorice root): Contains glycyrrhizin, which can cause pseudoaldosteronism (potassium loss, sodium retention, elevated blood pressure) with prolonged use. It may interact with antihypertensive medications, diuretics (especially potassium-depleting types like furosemide and hydrochlorothiazide), corticosteroids, and cardiac glycosides such as digoxin (hypokalemia increases digoxin toxicity).

Dang Gui (Angelica sinensis): Has mild anticoagulant and antiplatelet properties. It may enhance the effects of blood-thinning medications including warfarin, heparin, aspirin, and other antiplatelet drugs. Patients on anticoagulant therapy should be monitored for increased bleeding risk.

Huang Qin (Scutellaria baicalensis): Baicalin and baicalein have demonstrated interactions with certain medications metabolized by CYP enzymes, potentially affecting drug levels. There are case reports suggesting it may interact with cyclosporine and other immunosuppressants.

Chai Hu (Bupleurum): Saikosaponins have been reported to affect hepatic drug metabolism. In a large epidemiological study of patients with hepatitis B virus infection, Bupleurum-containing formulas were associated with a small but statistically significant increased risk of liver injury requiring hospitalization, particularly in higher cumulative doses. Patients with pre-existing liver disease should use Bupleurum-containing formulas with appropriate monitoring.

Usage Guidance

Practical advice for getting the most out of Chai Hu Qing Gan Tang

Best time to take

30 minutes before meals, or between meals on an empty stomach, twice daily (morning and evening).

Typical duration

Acute conditions (boils, tonsillitis flare-ups): 5-10 days. Constitutional use in children: 4-8 weeks, then reassessed by practitioner.

Dietary advice

While taking this formula, avoid foods that generate Heat or aggravate Liver Fire, including alcohol, spicy foods (chili peppers, black pepper, raw garlic, raw ginger), fried and greasy foods, and rich meats such as lamb and venison. Coffee and strong tea should also be limited as they can stir Liver Heat. Foods that gently clear Heat and support the Liver are recommended: leafy greens (especially celery, chrysanthemum greens, and watercress), mung beans, cucumber, pears, watermelon (in moderation), and chrysanthemum tea. Since the formula is cooling, patients with weak digestion should ensure food is warm and easily digestible to avoid further taxing the Spleen and Stomach.

Chai Hu Qing Gan Tang originates from Wai Ke Zheng Zong (外科正宗, Orthodox Manual of External Medicine) by Chen Shigong (陈实功) Míng dynasty, 1617 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Chai Hu Qing Gan Tang and its clinical use

《外科正宗》(Wài Kē Zhèng Zōng, Surgical Classics, 1617) by Chen Shigong — Bin Ju Men (鬓疽門, Chapter on Temple Abscesses):

The formula is recorded as the treatment for early-stage boils on the temple area (鬓疽初起未成者), regardless of whether the pattern is Yin or Yang, exterior or interior, and for Liver Fire congestion causing abscesses on the flanks (肝火壅盛,并胁生痈疽).

《医宗金鉴》(Yī Zōng Jīn Jiàn, Golden Mirror of Medicine, 1742):

This Qing dynasty imperial medical compendium reprinted the Wai Ke Zheng Zong version of Chai Hu Qing Gan Tang, consolidating its status as a standard formula for clearing Liver-Gallbladder channel Heat with toxic swelling in the head and neck regions.

Historical Context

How Chai Hu Qing Gan Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Chai Hu Qing Gan Tang has a complex historical lineage spanning Chinese and Japanese herbal medicine traditions. The earliest version appeared in Chen Shigong's Wai Ke Zheng Zong (外科正宗, Surgical Classics) published in 1617 during the Ming Dynasty. This 12-herb formula was designed to treat boils and abscesses along the temple region, attributed to Liver Fire congestion. It was later reprinted in the influential Qing dynasty imperial text Yi Zong Jin Jian (医宗金鉴, Golden Mirror of Medicine, 1742), which cemented its place in the standard surgical repertoire.

The version most widely used today, particularly in Japan and Taiwan, was created by the Japanese Kampo physician Mori Dōhaku (森道伯, active late Meiji to early Shōwa period). Mori practiced at a clinic he called Ikkandō (一貫堂), a name derived from a passage in the Analerta of Confucius. He developed a constitutional medicine framework identifying three body types, one of which he called the 'detoxification constitution' (解毒証体質). For this constitution in childhood, he created a 15-herb version of Chai Hu Qing Gan Tang by combining Wen Qing Yin (a union of Si Wu Tang and Huang Lian Jie Du Tang) with additional Wind-dispersing and toxin-resolving herbs including Jie Geng, Niu Bang Zi, Tian Hua Fen, Bo He, and Gan Cao. His student Yasu Itaru (矢数格) later documented and transmitted these formulas, and Mori's broader legacy was carried forward by the eminent scholar Yasu Dōmei (矢数道明).

In modern Japanese Kampo practice, Chai Hu Qing Gan Tang (Tsumura formula #80) is primarily used for children with a scrofulous constitution, marked by nervous temperament, tendency to swollen lymph nodes, chronic tonsillitis, eczema, and skin conditions. It remains one of the key Ikkandō formulas alongside Keigai Rengyo Tō (荊芥連翹湯) for adolescents and Ryūtan Shakan Tō (竜胆瀉肝湯) for urogenital conditions, all sharing the same constitutional framework.

Modern Research

A published study investigating the pharmacological effects or clinical outcomes of Chai Hu Qing Gan Tang

1

Application of Microwave Ablation Combined With Chai Hu Qing Gan Tang in the Treatment of Idiopathic Granulomatous Mastitis (Clinical Study, 2025)

PubMed, 2025 (exact journal details available via PMID)

A study of 480 patients divided into three groups compared Chai Hu Qing Gan Tang combined with microwave ablation against corticosteroid combination therapy and corticosteroids alone for idiopathic granulomatous mastitis. The study used network pharmacology to identify active ingredients and therapeutic targets. Results indicated that the herbal-ablation combination showed promising treatment outcomes.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.