Juan Bi Tang

Remove Painful Obstruction Decoction · 蠲痹湯

Also known as: Remitting Bi Decoction, Remove Obstruction Decoction

A classical formula used to relieve joint and muscle pain, stiffness, and numbness caused by Wind, Cold, and Dampness, especially when the body's own defensive and nourishing functions are weakened. It is particularly well suited for pain and tightness in the neck, shoulders, arms, and upper body that worsens in cold or damp weather.

Origin Yáng Shì Jiā Cáng Fāng (杨氏家藏方, Yang's Family Stored Formulas), Volume 4 — Sòng dynasty, 1178 CE
Composition 7 herbs
Qiang Huo
King
Qiang Huo
Fang Feng
King
Fang Feng
Huang Qi
Deputy
Huang Qi
Dang Gui
Deputy
Dang Gui
Bai Shao
Deputy
Bai Shao
Jiang Huang
Assistant
Jiang Huang
Gan Cao
Envoy
Gan Cao
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Juan Bi Tang is designed to correct these specific patterns.

Why Juan Bi Tang addresses this pattern

This is the primary pattern Juan Bi Tang addresses. Wind, Cold, and Dampness invade the channels, joints, and muscles when the body's Protective and Nutritive Qi are weakened. The three pathogens obstruct the normal flow of Qi and Blood through the channels, causing pain, stiffness, heaviness, and difficulty moving. Qiang Huo and Fang Feng directly expel Wind and Dampness, while Jiang Huang enters the limbs to break through local Blood stasis caused by the obstruction. Huang Qi strengthens the Protective Qi to close the exterior and prevent further invasion, and Dang Gui with Bai Shao nourish the Blood and harmonize the Nutritive layer. The overall effect is to clear the channels, restore Qi and Blood flow, and eliminate the painful obstruction.

A practitioner would look for one or more of these signs

Moving Pain

Pain in shoulders, neck, arms, and upper body that worsens in cold or damp weather

Stiff Neck

Stiffness and tightness in the neck and upper back

Skin Numbness

Numbness or tingling in the hands and feet

Difficulty In Moving

Difficulty moving the limbs, heaviness in the lower back and legs

Cold Hands

Cold hands and feet, cold painful obstruction in the extremities

Muscle Weakness

Weakness of the sinews and muscles, lack of strength

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Juan Bi Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, rheumatoid arthritis falls under the category of Bi syndrome (painful obstruction). It is understood as Wind, Cold, and Dampness invading the channels and joints, obstructing the flow of Qi and Blood. Over time, the obstruction can generate local Blood stasis and even Phlegm, leading to joint swelling and deformity. The condition typically develops in people with weakened Protective and Nutritive Qi, which is why flares often correlate with weather changes, fatigue, or cold exposure. The Spleen's role in transforming Dampness is also important, as internal Dampness from Spleen weakness can combine with external Dampness to worsen the obstruction.

Why Juan Bi Tang Helps

Juan Bi Tang is well suited for the wind-cold-damp presentation of rheumatoid arthritis because it simultaneously expels the external pathogenic factors and strengthens the body's internal defenses. Qiang Huo and Fang Feng clear Wind and Dampness from the channels. Huang Qi tonifies the Qi to prevent recurrent invasion. Dang Gui and Bai Shao nourish the Blood and keep the joints and sinews supplied. Jiang Huang is particularly effective for upper limb joint pain and moves Blood through obstructed channels. Clinical studies have shown that adding Juan Bi Tang to conventional treatment can help reduce joint tenderness, swelling, and morning stiffness in RA patients.

Also commonly used for

Osteoarthritis

Knee and other joint degenerative changes with cold-damp pattern

Ankylosing Spondylitis

Spinal stiffness and pain with wind-cold-damp pattern

Sciatica

When caused by wind-cold-damp obstruction

Lower Back Pain

Upper back stiffness and pain aggravated by cold

Skin Numbness

Peripheral numbness of hands and feet

What This Formula Does

Every TCM formula has a specific set of actions — here's what Juan Bi Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Juan Bi Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Juan Bi Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Juan Bi Tang works at the root level.

Juan Bi Tang addresses a pattern where painful obstruction (Bi syndrome) arises because Wind, Cold, and Dampness have invaded the body's channels, muscles, and joints in a person whose defenses are already weakened. The classical texts describe this as the Nutritive Qi (Ying Qi) and Protective Qi (Wei Qi) being insufficient. Normally, the Protective Qi circulates along the body's surface and acts like a shield, keeping pathogenic influences out, while the Nutritive Qi flows through the channels nourishing the muscles and sinews. When both are deficient, Wind, Cold, and Dampness slip in easily and lodge in the spaces between the muscles, joints, and channels.

Once these three pathogenic factors settle in, they obstruct the normal flow of Qi and Blood through the affected areas. Wind causes the pain to migrate or shift locations. Cold constricts and tightens, causing sharp pain that worsens in cold weather. Dampness is heavy and sticky, making the limbs feel leaden, swollen, and stiff. Together they create a classic picture: generalized aching, stiff and painful neck, shoulders, and arms, cold hands and feet, heavy legs and lower back, and weak, powerless sinews. The tongue is typically pale with a white, greasy coating, and the pulse tends to be floating or slippery, reflecting both the external pathogen lodged on the surface and the underlying weakness.

Because the root problem involves both an external invasion and an internal deficiency, simply driving out the Wind-Damp is not enough. Aggressive dispersing herbs used alone would further weaken the Qi and Blood. At the same time, simply tonifying without expelling the pathogens would trap them inside. Juan Bi Tang is designed to do both simultaneously: it expels the pathogens from the channels while strengthening the body's Qi and nourishing its Blood, so the body can resist further invasion and the channels can recover their normal circulation.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly acrid and sweet, with mild bitterness. The acrid taste disperses Wind-Cold-Damp from the channels, the sweet taste tonifies Qi and Blood to support the body's defenses, and the mild bitterness helps dry Dampness.

Channels Entered

Ingredients

7 herbs

The herbs that make up Juan Bi Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Qiang Huo

Qiang Huo

Notopterygium roots

Dosage 9g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Urinary Bladder, Kidneys

Role in Juan Bi Tang

Disperses Wind-Cold-Dampness from the upper body, unblocks the channels, and relieves joint pain. As a King herb, it directly targets the primary pathogenic factors (Wind and Dampness) lodged in the muscles, channels, and joints.
Fang Feng

Fang Feng

Saposhnikovia roots

Dosage 9g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Urinary Bladder, Liver, Spleen

Role in Juan Bi Tang

Disperses Wind and overcomes Dampness without being excessively drying. Works alongside Qiang Huo to expel pathogenic Wind from the exterior and channels, and has a synergistic relationship with Huang Qi where each enhances the other's effectiveness.
Deputies — Assists and enhances the King
Huang Qi

Huang Qi

Milkvetch roots

Dosage 9g
Temperature Warm
Taste Sweet
Organ Affinity Lungs, Spleen

Role in Juan Bi Tang

Tonifies Qi and strengthens the Protective Qi (Wei Qi), addressing the underlying deficiency that allowed pathogenic factors to invade. Its Qi-boosting action also drives the wind-dispelling herbs to work more effectively.
Dang Gui

Dang Gui

Dong quai

Dosage 9g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Heart, Liver, Spleen
Preparation Soaked in wine overnight (酒浸一宿)

Role in Juan Bi Tang

Nourishes and activates the Blood, harmonizes the Nutritive Qi (Ying Qi). Addresses the Blood deficiency component of the pattern and prevents the wind-dispelling herbs from drying out the Blood.
Bai Shao

Bai Shao

White peony roots

Dosage 9g
Temperature Neutral
Taste Bitter, Sour
Organ Affinity Liver, Spleen

Role in Juan Bi Tang

Nourishes the Blood and softens the Liver, relaxes the sinews, and alleviates pain. Works with Dang Gui to nourish Blood and harmonize the Nutritive Qi, supporting the body's ability to expel pathogenic factors.
Assistant — Supports or moderates other herbs
Jiang Huang

Jiang Huang

Turmeric

Dosage 9g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Liver, Spleen

Role in Juan Bi Tang

Moves Qi within the Blood, breaks through Blood stasis in the channels, enters the arms and upper limbs specifically, and dispels Cold-Dampness from the joints. Empirically effective for shoulder and arm pain.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Liquorice

Dosage 3g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Juan Bi Tang

Harmonizes all the herbs in the formula, tonifies the Middle Qi, and moderates the dispersing properties of the wind-expelling herbs to protect the Spleen and Stomach.

Why This Combination Works

How the herbs in Juan Bi Tang complement each other

Overall strategy

This formula addresses painful obstruction (Bi syndrome) that arises from both an external cause (Wind-Cold-Dampness invading the channels) and an internal weakness (deficiency of the Protective and Nutritive Qi). The prescription therefore works on two fronts simultaneously: expelling the pathogenic factors while strengthening the body's own Qi and Blood.

King herbs

Qiang Huo and Fang Feng serve as the King herbs. Qiang Huo is one of the strongest herbs for dispersing Wind-Dampness from the upper body and Tai Yang channel, directly unblocking the channels where pain and stiffness lodge. Fang Feng complements it by gently expelling Wind and overcoming Dampness without being excessively drying or harsh. Together they form a powerful pair that opens the channels and drives out the three pathogenic factors (Wind, Cold, and Dampness) responsible for the obstruction.

Deputy herbs

Huang Qi (honey-processed) tonifies the Protective Qi and strengthens the body's exterior, addressing the root deficiency that allowed pathogens to invade. Dang Gui and Bai Shao nourish the Blood and harmonize the Nutritive Qi. This is critical because, as classical sources note, "when Nutritive Qi is deficient there is numbness, when Protective Qi is deficient there is loss of function." The Deputies ensure the body has sufficient Qi and Blood to support recovery and prevent the drying, dispersing King herbs from depleting vital substances.

Assistant herbs

Jiang Huang (turmeric rhizome) serves as a reinforcing assistant that moves Qi within the Blood and penetrates into the limbs, especially the shoulders and arms. It breaks through Blood stasis caused by prolonged obstruction and dispels Cold-Dampness from the channel pathways. Fresh ginger (Sheng Jiang), added during decoction, warms the Middle Burner and helps the exterior-releasing herbs reach the surface. Chinese dates (Da Zao), when included, nourish the Spleen and harmonize Nutritive and Protective Qi.

Envoy herbs

Zhi Gan Cao (honey-processed licorice) harmonizes all the ingredients in the formula, buffers the Middle Burner, and ensures the dispersing herbs do not injure the Spleen and Stomach. Together with Sheng Jiang and Da Zao, it bridges the gap between Nutritive and Protective Qi, helping restore their coordination.

Notable synergies

The pairing of Huang Qi with Fang Feng is a celebrated combination: although they are classically described as mutually "restraining" (相畏), when used together Huang Qi's tonifying power is accelerated by Fang Feng's dispersing action, achieving both fortification and expulsion simultaneously. Qiang Huo paired with Dang Gui ensures that Wind is dispersed without drying the Blood. Jiang Huang paired with Bai Shao balances Blood-moving and Blood-nourishing actions, enabling the formula to reach deep into the channel pathways of the upper limbs.

How to Prepare

Traditional preparation instructions for Juan Bi Tang

Roughly chop the herbs. Use 15g of the combined herbs per serving. Add 300ml of water and 3–5 slices of fresh ginger (Sheng Jiang). Optionally add 2 pieces of Chinese date (Da Zao). Bring to a boil, then simmer until the liquid is reduced to approximately 150ml. Strain off the dregs and take the decoction warm, without regard to mealtimes. Typically taken twice daily.

Modern usage: Decoct all herbs together in approximately 400–500ml of water for 20–30 minutes. Strain and divide into two doses, taken morning and evening.

Common Modifications

How practitioners adapt Juan Bi Tang for specific situations

Added
Qin Jiao

6-9g, expels Wind-Dampness from the channels and sinews

Wei Ling Xian

9-12g, powerfully unblocks the channels and dissolves obstruction

When Wind predominates, the pain migrates between joints. Adding Qin Jiao and Wei Ling Xian strengthens the formula's ability to chase Wind through the channels and relieve the wandering pain.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Juan Bi Tang should not be used or requires extra caution

Avoid

Damp-Heat or Wind-Heat Bi syndrome, where there are signs of heat such as red, hot, swollen joints, fever, thirst, dark urine, or a yellow greasy tongue coating. This formula is warming in nature and will worsen heat patterns.

Avoid

Yin-deficiency with Heat signs. The warm, drying, and dispersing herbs in this formula can further consume Yin fluids and aggravate internal Heat.

Caution

Severe Blood deficiency without concurrent Wind-Damp invasion. While the formula contains Blood-nourishing herbs, its primary strategy is to dispel external pathogens, which can further deplete an already weakened constitution if no external pathogen is present.

Caution

Acute febrile illness with strong exterior symptoms unrelated to Bi syndrome. The formula's tonifying herbs (Huang Qi) can trap pathogens inside if used during an acute Wind-Heat exterior invasion.

Caution

Long-standing Bi syndrome that has transformed into Liver and Kidney deficiency with bone deformity. This formula primarily addresses Wind-Damp at the level of the channels and muscles, not deep deficiency of Liver and Kidney. Formulas with stronger Liver-Kidney tonics would be more appropriate.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Jiang Huang (Curcuma longa rhizome) activates Blood circulation and has been traditionally considered to promote movement of Blood, which could theoretically stimulate uterine activity. Qiang Huo is a strongly dispersing, acrid herb that should also be used cautiously. While no individual herb in the standard Yang Shi Jia Cang Fang version is a strong abortifacient, the overall Blood-moving and Wind-dispersing strategy of the formula warrants caution. A qualified practitioner should assess whether the benefits outweigh risks. If modifications using the Yi Xue Xin Wu version are employed (which adds Ru Xiang/Frankincense and Gui Zhi/Cinnamon Twig), the Blood-moving and warming properties are even stronger, increasing the caution level.

Breastfeeding

No specific classical or modern contraindications for breastfeeding have been established for the standard Yang Shi Jia Cang Fang version of Juan Bi Tang. The formula's herbs are generally mild to moderate in potency. However, the acrid, dispersing nature of Qiang Huo and Fang Feng means small amounts of their volatile components could theoretically pass into breast milk. Jiang Huang (turmeric rhizome) is widely used as a food spice and is generally considered safe, but its Blood-moving properties warrant some caution. A practitioner should be consulted before use during breastfeeding, and the infant should be monitored for any digestive changes.

Children

Juan Bi Tang is not commonly prescribed for children, as Bi syndrome due to Wind-Cold-Damp invasion with underlying Qi and Blood deficiency is primarily an adult condition. If used in adolescents (roughly age 12 and above) with confirmed Bi-pattern joint pain, dosages should be reduced to approximately 50-70% of adult levels depending on body weight. For younger children, the formula is generally not appropriate. A pediatric TCM practitioner should be consulted, as children's conditions presenting as joint pain more often require different diagnostic approaches. The formula contains no inherently toxic herbs in its standard composition.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Juan Bi Tang

Anticoagulants and antiplatelet drugs (e.g. warfarin, aspirin, clopidogrel): Dang Gui (Angelica sinensis) and Jiang Huang (Curcuma longa/turmeric) both have documented Blood-activating properties. Curcumin from Jiang Huang has been shown to have mild antiplatelet effects. Concurrent use with anticoagulants may increase bleeding risk and requires monitoring of INR/clotting parameters.

Antihypertensive medications: Huang Qi (Astragalus) may modulate blood pressure. While typically it raises blood pressure slightly through Qi-tonifying action, interactions are possible in patients on blood-pressure-lowering medications. Monitor blood pressure when combining.

Immunosuppressant drugs (e.g. methotrexate, biologics): Several clinical studies have combined Juan Bi Tang with methotrexate for rheumatoid arthritis. While these studies suggest additive benefit, the immune-modulating effects of both the formula and the drug mean that any combination use should be supervised by a qualified practitioner familiar with both TCM and conventional medicine.

Hypoglycemic agents: Huang Qi has been reported to have mild blood-sugar-lowering effects in some studies. Patients on insulin or oral hypoglycemics should monitor blood glucose levels.

Usage Guidance

Practical advice for getting the most out of Juan Bi Tang

Best time to take

Warm, after meals (about 30 minutes), twice daily (morning and evening). Taking after meals reduces the risk of gastric irritation from the acrid herbs. The decoction should be taken warm to enhance the formula's warming, dispersing action.

Typical duration

Chronic Bi syndrome: typically 4-8 weeks as an initial course, then reassessed. Sub-acute flare-ups: 2-4 weeks. Dosage and duration are adjusted by the practitioner based on symptom response.

Dietary advice

While taking this formula, avoid cold and raw foods (such as salads, iced drinks, raw sushi, and cold fruits) as these can worsen Cold-Damp accumulation in the channels and counteract the warming, dispersing nature of the formula. Greasy, heavy, and excessively sweet foods should also be limited, as they generate internal Dampness that aggravates Bi syndrome. Foods that support the formula's strategy include warm soups, ginger tea, moderate amounts of lamb or chicken (warming proteins), and cooked grains. Avoid exposure to cold, damp, and windy environments during treatment, as this can reintroduce the very pathogens the formula is working to expel. Moderate exercise to promote Qi and Blood circulation in the joints is beneficial, but overexertion should be avoided.

Juan Bi Tang originates from Yáng Shì Jiā Cáng Fāng (杨氏家藏方, Yang's Family Stored Formulas), Volume 4 Sòng dynasty, 1178 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Juan Bi Tang and its clinical use

Yang Shi Jia Cang Fang (杨氏家藏方), Volume 4:
Original indication: 「风湿相搏,身体烦疼,项臂痛重,举动艰难,及手足冷痹,腰腿沉重,筋脉无力。」
"Wind and Dampness contending with each other, causing generalized body aches and irritability, heaviness and pain of the neck and arms, difficulty moving, cold painful obstruction of the hands and feet, heaviness of the low back and legs, and weakness of the sinews."

Yi Fang Kao (医方考) by Wu Kun:
「《内经》曰:荣气虚则不仁,卫气虚则不用。」
"The Nei Jing states: when the Nutritive Qi is deficient there is numbness; when the Protective Qi is deficient there is loss of function." Wu Kun explains that Huang Qi firms the Exterior Qi, and while it is traditionally said to 'fear' Fang Feng, Zhang Jiegu taught that Huang Qi combined with Fang Feng actually works faster, using their 'mutual fear' to 'mutual assistance' effect.

Yi Fang Ji Jie (医方集解) by Wang Ang:
「此足太阳厥阴药。辛能散寒,风能胜湿,防风、羌活除湿而疏风。气通则血活,血活则风散。」
"This is a formula for the Foot Taiyang and Jueyin channels. Acrid [herbs] can scatter Cold, Wind can overcome Dampness; Fang Feng and Qiang Huo dispel Dampness and release Wind. When Qi flows freely, Blood becomes active; when Blood is active, Wind disperses."

Gu Fang Xuan Zhu (古方选注):
「蠲痹汤为治痹祖方。」
"Juan Bi Tang is the ancestral formula for treating Bi syndrome." The text notes that its treatment principle is built upon the Nei Jing teaching that Nutritive deficiency leads to numbness and Protective deficiency leads to loss of function, addressing both internal and external causes of Bi.

Historical Context

How Juan Bi Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Origins and source text: Juan Bi Tang (蠲痹汤, "Remove Painful Obstruction Decoction") first appeared in the Song Dynasty text Yang Shi Jia Cang Fang (杨氏家藏方, "Yang's Family Treasury of Formulas"), Volume 4, attributed to Yang Tan (杨倓), published around 1178 CE. The character "蠲" (juan) means to eliminate or drive away swiftly, reflecting the formula's aim to rapidly relieve Bi syndrome. Some sources cite Bai Yi Xuan Fang (百一选方) as an earlier or parallel source for the same formula. The Gu Fang Xuan Zhu (古方选注) famously called it "the ancestral formula for treating Bi" (治痹祖方), underlining its foundational importance in the treatment of painful obstruction disorders.

A second formula with the same name: The Qing Dynasty physician Cheng Guopeng (程国彭) recorded a different formula also called Juan Bi Tang in his Yi Xue Xin Wu (医学心悟, "Medical Revelations", 1732 CE). This later version has 11 herbs (including Du Huo, Gui Xin, Qin Jiao, Hai Feng Teng, Sang Zhi, Chuan Xiong, Ru Xiang, and Mu Xiang) and takes a more aggressive approach to expelling Wind-Cold-Damp without the Qi and Blood tonifying emphasis of the original. The famous modern TCM practitioner Jiao Shude (焦树德) favored this Yi Xue Xin Wu version for treating upper body Bi syndrome in patients who did not have underlying Liver-Kidney deficiency. In 2018, the Yi Xue Xin Wu version of Juan Bi Tang was selected as one of the first 100 ancient classical TCM formulas by China's National Administration of Traditional Chinese Medicine, reflecting its continued clinical importance. A third variant appears in Wei Shi Jia Cang Fang (魏氏家藏方), which adds Fu Zi (Aconite), Bai Zhu, and Yi Yi Ren for more severe Wind-Damp with pronounced Qi weakness.

Enduring clinical influence: The formula's principle of simultaneously expelling pathogens and supporting the body's Qi and Blood has become a model for treating chronic Bi syndrome in patients with underlying deficiency. The Yi Fang Kao commentary highlights the clever pairing of Huang Qi with Fang Feng, citing Zhang Jiegu's (张洁古) teaching that these two herbs, though traditionally considered to 'oppose' each other, actually enhance each other's effect when combined: Fang Feng disperses Wind without weakening Qi, while Huang Qi strengthens defenses without trapping pathogens. This principle of "mutual fear yielding mutual assistance" (相畏相使) has become a widely taught example in TCM pharmacology.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Juan Bi Tang

1

Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model (Preclinical, 2020)

Wang T, Jia Q, Chen T, Yin H, Tian X, Lin X, Liu Y, Zhao Y, Wang Y, Shi Q, Huang C, Xu H, Liang Q. Frontiers in Pharmacology, 2020, 11:45.

This animal study tested Juan Bi Tang (Yi Xue Xin Wu version) in two mouse models of rheumatoid arthritis. The formula significantly reduced joint inflammation, bone destruction, and cartilage damage in both collagen-induced arthritis mice and TNF-transgenic mice. It suppressed inflammatory macrophages and T cells, reduced pro-inflammatory cytokines (IL-6, IL-8), and inhibited MMP-1 expression. The mechanism appeared to involve blocking the NF-kappa B signaling pathway.

DOI
2

Systematic Investigation on the Anti-Rheumatoid Arthritis Material Basis and Mechanism of Juan Bi Tang. Part 1: Integrating Metabolic Profiles and Network Pharmacology (Preclinical, 2021)

Li J, Li L, Wang Y, Zhao Y, Hu P, Xu Z, Liu F, Liang Q, Tian X, Huang C. Journal of Pharmaceutical and Biomedical Analysis, 2021, 202:114133.

This study investigated the absorbed chemical components and anti-rheumatoid arthritis mechanisms of Juan Bi Tang (Yi Xue Xin Wu version) using HPLC-Q-TOF mass spectrometry in collagen-induced arthritis rats. Researchers identified 18 absorbed compounds and 17 metabolites. Network pharmacology analysis predicted that the formula's anti-RA activity works through the MAPK, FoxO, and Rap1 signaling pathways, validated by molecular docking.

DOI

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.