Formula Pill (Wan)

Yue Ju Wan

Escape Restraint Pill · 越鞠丸

Also known as: Qiong Shu Wan (芎术丸), Yue Qu Wan (越曲丸)

A classical formula designed to relieve multiple types of internal 'stagnation' that develop when the body's Qi stops flowing smoothly. It is commonly used for digestive complaints like bloating, acid reflux, nausea, and poor appetite, as well as for stress-related discomfort including chest tightness and flank pain. The formula works by restoring the smooth movement of Qi, Blood, and fluids throughout the body.

Origin Dan Xi Xin Fa (丹溪心法), Volume 3 — Yuán dynasty, ~1347 CE
Composition 5 herbs
Xiang Fu
King
Xiang Fu
Chuan Xiong
Deputy
Chuan Xiong
Cang Zhu
Assistant
Cang Zhu
Zhi Zi
Assistant
Zhi Zi
Shen Qu
Assistant
Shen Qu
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Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Yue Ju Wan is designed to correct these specific patterns.

Why Yue Ju Wan addresses this pattern

Yue Ju Wan is a primary formula for Liver Qi stagnation when it has progressed beyond simple emotional constraint into a complex of intertwined stagnations affecting digestion, circulation, and fluid metabolism. Xiang Fu, the King herb, directly unblocks constrained Liver Qi, while Chuan Xiong assists by moving both Qi and Blood through the Liver and Gallbladder channels. Because the Liver's stagnation impairs the Spleen's function (the Liver 'overacting' on the Spleen), Cang Zhu and Shen Qu restore the Spleen and Stomach, and Zhi Zi clears any Heat generated by the stagnation. The formula is best suited when Liver Qi stagnation has produced multiple secondary pathologies rather than existing in isolation.

A practitioner would look for one or more of these signs

Chest Stiffness

Feeling of stuffiness and distension in the chest and upper abdomen

Hypochondriac Pain

Distending pain in the flanks and rib area

Abdominal Distention

Epigastric and abdominal bloating and fullness

Belching

Belching with foul or sour odor

Acid Reflux

Acid regurgitation and sour taste in the mouth

Nausea

Nausea or vomiting

Poor Appetite

Reduced appetite with food sitting undigested

Irritability

Emotional irritability and frustration

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Yue Ju Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, chronic gastritis is understood primarily as a disorder of the Spleen and Stomach, often triggered or worsened by Liver Qi stagnation. When emotional stress or irregular eating habits cause the Liver's Qi to become constrained, it 'overacts' on the Spleen and Stomach, disrupting their normal ascending and descending functions. This leads to food stagnating in the Stomach, Dampness accumulating from impaired Spleen transport, and Heat building from prolonged Qi constraint. The result is the classic pattern of epigastric pain, bloating, acid reflux, nausea, and poor appetite.

Why Yue Ju Wan Helps

Yue Ju Wan addresses the multiple layers of stagnation that underlie chronic gastritis. Xiang Fu unblocks the constrained Liver Qi that is 'attacking' the Stomach. Cang Zhu dries the accumulated Dampness in the middle burner and restores the Spleen's transport function. Shen Qu directly disperses food that has stagnated in the Stomach. Zhi Zi clears the Heat responsible for acid reflux and burning sensations. Chuan Xiong keeps both Qi and Blood flowing smoothly. Clinical studies have shown Yue Ju Wan (with modifications) to be effective for bile reflux gastritis and functional dyspepsia, often outperforming conventional prokinetic agents.

Also commonly used for

Irritable Bowel Syndrome

When related to stress and Qi stagnation

Cholecystitis

With Qi stagnation pattern

Gallstones

Supportive treatment with stagnation symptoms

Chronic Hepatitis

With Liver Qi stagnation and digestive symptoms

Amenorrhea

Painful periods due to Qi and Blood stagnation

Irregular Menstruation

When caused by Liver Qi constraint

Acid Reflux

Bile reflux gastritis and acid regurgitation

Intercostal Neuralgia

Rib-area pain along Liver channel distribution

Migraine

Headaches related to Liver Qi stagnation

What This Formula Does

Every TCM formula has a specific set of actions — here's what Yue Ju Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Yue Ju Wan is primarily used to support these areas of health:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Yue Ju Wan works at the root level.

Yue Ju Wan addresses a condition the classical texts call the "Six Stagnations" (六郁 liu yu), a pattern where the body's normal circulation of Qi, Blood, and fluids becomes obstructed, and multiple types of blockage pile up together. The root insight behind this formula is that Qi stagnation is the primary driver of all other forms of stagnation. When Qi stops moving freely, everything else backs up: Blood flow slows down, body fluids accumulate as Dampness or thicken into Phlegm, digestion stalls and food sits unprocessed, and pent-up Qi transforms into internal Heat (Fire).

The organ systems most involved are the Liver and the Spleen/Stomach. The Liver is responsible for the smooth flow of Qi throughout the body. Emotional stress, frustration, or unfulfilled desires cause the Liver's spreading function to seize up, leading to Qi stagnation. This Liver Qi then "invades" the Spleen and Stomach, disrupting their ability to transform food and fluids and to move things upward and downward properly. The result is a cascade: stagnant Qi leads to Blood stasis (pain), accumulated Dampness (heaviness, greasy tongue coating), undigested food (bloating, acid reflux, belching), and smoldering Fire (irritability, bitter taste). Because these six forms of stagnation are interrelated and mutually reinforcing, the formula's strategy is to break the cycle at its source by restoring Qi movement, while simultaneously addressing each of the secondary stagnations.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly acrid and bitter, with mild sweetness. The acrid taste moves Qi and Blood, the bitter taste clears Heat and dries Dampness, and the mild sweetness harmonizes the Stomach.

Ingredients

5 herbs

The herbs that make up Yue Ju Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Xiang Fu

Xiang Fu

Nutgrass rhizome

Dosage 6 - 10g
Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Liver, Spleen, San Jiao (Triple Burner)
Preparation Vinegar-processed (醋制) to enhance its Liver-entering and pain-relieving properties

Role in Yue Ju Wan

The chief herb for resolving Qi stagnation. Xiang Fu enters the Liver channel, where it excels at spreading constrained Liver Qi, relieving chest and abdominal distension and pain. As Qi stagnation is the root of the six types of stagnation addressed by this formula, resolving Qi stagnation is the primary therapeutic strategy.
Deputy — Assists and enhances the King
Chuan Xiong

Chuan Xiong

Szechuan lovage rhizome

Dosage 6 - 10g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium

Role in Yue Ju Wan

Known as the 'Qi herb within the Blood', Chuan Xiong has a dual action: it invigorates Blood and dispels Blood stasis to address Blood stagnation, while also assisting Xiang Fu in moving Qi. Its upward and outward dispersing nature helps lift and open stagnation in the middle burner.
Assistants — Supports or moderates other herbs
Cang Zhu

Cang Zhu

Atractylodes rhizome

Dosage 6 - 10g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Liver
Preparation Dry-fried (炒) to moderate its drying nature

Role in Yue Ju Wan

Dries Dampness and strengthens the Spleen to address Dampness stagnation. By restoring the Spleen's ability to transform and transport, it also indirectly resolves Phlegm stagnation, since Phlegm arises from accumulated Dampness. Its warm, aromatic nature helps 'awaken' a sluggish middle burner.
Zhi Zi

Zhi Zi

Gardenia fruit

Dosage 6 - 10g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, San Jiao (Triple Burner)
Preparation Dry-fried (炒) to reduce its cold nature and protect the Stomach

Role in Yue Ju Wan

Clears Heat and drains Fire to address Fire (Heat) stagnation. When Qi stagnates for a prolonged period, it tends to transform into Heat, leading to symptoms like acid reflux and irritability. Zhi Zi clears Heat from all three burners and cools the Blood, preventing the cascade from Qi stagnation to Fire.
Shen Qu

Shen Qu

Medicated leaven

Dosage 6 - 10g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach
Preparation Dry-fried (炒) to enhance its digestive action

Role in Yue Ju Wan

Disperses Food stagnation and harmonizes the Stomach to address Food stagnation. When the Spleen and Stomach lose their normal function of transporting and transforming food due to Qi stagnation, undigested food accumulates. Shen Qu gently promotes digestion and restores the Stomach's descending function.

Why This Combination Works

How the herbs in Yue Ju Wan complement each other

Overall strategy

Yue Ju Wan addresses the pathomechanism of intertwined stagnation in the Liver and Spleen by using five herbs, each targeting one of the five tangible forms of stagnation (Qi, Blood, Dampness, Fire, Food), with the overarching principle that resolving Qi stagnation will help unravel all the rest. The sixth type of stagnation, Phlegm, is treated indirectly through the combined effects of drying Dampness, clearing Fire, and dispersing Food accumulation.

King herbs

Xiang Fu (Cyperus) serves as the sole King herb. It is considered the premier substance for moving constrained Liver Qi, described in the Ben Cao Gang Mu as the 'chief commander of Qi disorders.' Since Qi stagnation is the root cause from which the other five types of stagnation develop, placing Xiang Fu in the leading role ensures the formula strikes at the fundamental problem. When Qi flows freely, Blood circulates, Dampness transforms, Fire dissipates, and Food digests.

Deputy herbs

Chuan Xiong (Sichuan Lovage) reinforces the King from the Blood level. Classical texts call it the 'Qi herb within the Blood' because it simultaneously moves both Qi and Blood. It directly resolves Blood stasis while powerfully assisting Xiang Fu's Qi-moving action. Together, this pair ensures that both the Qi and Blood aspects of Liver constraint are addressed.

Assistant herbs

Cang Zhu (Atractylodes) is a reinforcing assistant that targets the Spleen. By drying Dampness and restoring the Spleen's transport function, it resolves Dampness stagnation and prevents Phlegm from forming. Zhi Zi (Gardenia) is a restraining assistant: it clears the Heat that inevitably arises from prolonged stagnation, while its cold nature balances the warm, drying herbs in the formula. Shen Qu (Medicated Leaven) is a reinforcing assistant that disperses accumulated Food and harmonizes the Stomach, restoring the digestive function that Qi stagnation has impaired.

Notable synergies

Xiang Fu and Chuan Xiong together form a classic Qi-and-Blood moving pair, each amplifying the other's dispersing action. Cang Zhu and Shen Qu work in tandem on the Spleen and Stomach, one drying Dampness while the other clears Food accumulation, together restoring the middle burner's crucial role in transformation and transport. The cold nature of Zhi Zi counterbalances the warmth of Cang Zhu and Chuan Xiong, preventing the formula from being overly drying or heating.

How to Prepare

Traditional preparation instructions for Yue Ju Wan

The original formula is prepared as a water pill (水丸). Grind all five herbs into a fine powder in equal proportions, mix thoroughly, then form into small pills the size of mung beans using water as a binding agent. Take 6 to 9 grams per dose with warm water, two to three times daily.

The formula may also be prepared as a decoction. Use 6 to 10 grams of each herb (maintaining equal proportions), decoct in approximately 400 ml of water for 20 to 30 minutes, and take the strained liquid in two divided doses per day.

Common Modifications

How practitioners adapt Yue Ju Wan for specific situations

Added
Mu Xiang

6g, to reinforce Qi movement in the middle and lower burner

Zhi Ke

6 - 9g, to break up Qi stagnation and relieve focal distension

Hou Pu

6 - 9g, to move Qi downward and reduce abdominal fullness

When Qi stagnation is the dominant complaint, increasing Xiang Fu's dosage and adding additional Qi-moving herbs intensifies the formula's primary action of restoring free Qi flow.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Yue Ju Wan should not be used or requires extra caution

Caution

Deficiency-type stagnation (xu zheng): This formula addresses excess-type stagnation only. People with underlying Qi, Blood, or Yin deficiency causing secondary stagnation should not use this formula alone, as its moving and dispersing nature may further deplete the body's resources. Tonifying herbs must be added in such cases.

Caution

Yin deficiency with Heat: The warm, acrid, and drying nature of most herbs in this formula (Cang Zhu, Chuan Xiong, Xiang Fu) can further injure Yin and body fluids. People with significant Yin deficiency signs such as night sweats, dry mouth, a red tongue with little coating, and a thin rapid pulse should avoid this formula or use it only with significant modification.

Caution

Excessive menstrual bleeding or active hemorrhage: Chuan Xiong is a strong Blood-moving herb. In people with heavy menstruation, uterine bleeding, or other active hemorrhage, this formula may worsen blood loss.

Caution

Pregnancy: Chuan Xiong (Ligusticum chuanxiong) strongly moves Blood and Qi, which poses a theoretical risk of stimulating uterine contractions. Xiang Fu also powerfully moves Qi. Use during pregnancy should be avoided unless under close practitioner supervision.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Chuan Xiong (Ligusticum chuanxiong) is a potent Blood-moving herb that may theoretically stimulate uterine activity. Xiang Fu (Cyperus rotundus) also strongly moves Qi in the lower abdomen. While neither is classified as a strict abortifacient, the combination of vigorous Qi-moving and Blood-activating actions makes this formula inadvisable during pregnancy without specific guidance from a qualified practitioner. If Qi stagnation must be addressed during pregnancy, milder alternatives should be considered.

Breastfeeding

No specific contraindications during breastfeeding have been reported in classical or modern sources. The herbs in this formula are generally considered mild at standard doses. Chuan Xiong and Xiang Fu are aromatic, Qi-moving substances that could theoretically affect the taste of breast milk, but clinically significant problems have not been documented. Zhi Zi (Gardenia) is cold and bitter, and prolonged high-dose use could theoretically affect digestion in a sensitive infant through breast milk. As a precaution, nursing mothers should use the formula only when clearly indicated and at standard doses, ideally under practitioner guidance.

Children

Yue Ju Wan can be used in children with appropriate dose reduction, though pediatric use is less commonly discussed in the classical literature. General guidelines: children aged 6-12 may take approximately one-third to one-half of the adult dose; adolescents over 12 can take two-thirds of the adult dose. Because the formula contains acrid, aromatic, and moving herbs (Cang Zhu, Chuan Xiong, Xiang Fu), it is generally not suitable for very young children (under 3) or for prolonged use in children, as their Qi and Yin are still developing and easily damaged by drying, dispersing substances. It is best used for short courses under practitioner supervision.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Yue Ju Wan

Anticoagulant and antiplatelet medications: Chuan Xiong (Ligusticum chuanxiong) has documented Blood-activating and circulation-promoting properties. Its active component ligustrazine (tetramethylpyrazine) has antiplatelet aggregation effects. Concurrent use with warfarin, heparin, aspirin, or clopidogrel may increase bleeding risk.

Antidepressant medications (SSRIs, SNRIs): Modern research shows Yue Ju Wan affects BDNF expression, serotonin (5-HT), and dopamine pathways. While one pilot study used the formula as an adjunct to fluoxetine without serious adverse events, theoretical interactions remain possible. Combined use should only be undertaken with medical supervision to monitor for signs of serotonergic excess.

Antihypertensive medications: Chuan Xiong's vasodilatory effects (via ligustrazine) could theoretically potentiate the effects of blood-pressure-lowering drugs, potentially causing excessive hypotension.

Usage Guidance

Practical advice for getting the most out of Yue Ju Wan

Best time to take

After meals, twice daily, with warm water. The classical source specifies 食后温服 (take warm after eating).

Typical duration

Typically prescribed for 1-4 weeks for acute stagnation patterns, then reassessed. Not intended for long-term continuous use due to its drying and dispersing nature.

Dietary advice

While taking this formula, avoid cold and raw foods, greasy or deep-fried foods, and heavy, rich meals that burden digestion, as these directly worsen the Dampness and food stagnation the formula is trying to resolve. Alcohol should be limited, as it generates Dampness and Heat. Favour lightly cooked, easily digestible meals with plenty of vegetables. Aromatic foods that gently move Qi, such as citrus peel, fresh ginger, and leafy greens, are supportive. Emotional regulation is also important: the classical texts emphasize that frustration and emotional suppression are primary causes of the Qi stagnation this formula treats.

Yue Ju Wan originates from Dan Xi Xin Fa (丹溪心法), Volume 3 Yuán dynasty, ~1347 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Yue Ju Wan and its clinical use

《丹溪心法·六郁》 (Dan Xi Xin Fa, Chapter on the Six Stagnations):

「气血冲和,万病不生,一有怫郁,诸病生焉。故人身诸病,多生于郁。」

"When Qi and Blood flow in harmony, the ten thousand diseases do not arise. Once there is constraint and stagnation, all manner of diseases are born. Therefore, the many diseases of the human body mostly arise from stagnation."

《丹溪心法》 (Dan Xi Xin Fa):

「越鞠丸,解诸郁。」

"Yue Ju Wan resolves all forms of stagnation."

《医方集解》 (Yi Fang Ji Jie) by Wang Ang, quoting Wu Hecquan:

「越鞠者,发越鞠郁之谓也。香附开气郁;苍术燥湿郁;抚芎调血郁;栀子解火郁;神曲消食郁。」

"'Yue Ju' means to release and liberate what is bound up in constraint. Xiang Fu opens Qi stagnation; Cang Zhu dries Dampness stagnation; Chuan Xiong regulates Blood stagnation; Zhi Zi resolves Fire stagnation; Shen Qu disperses Food stagnation."

《明医杂著》 (Ming Yi Za Zhu) by Wang Lun:

「丹溪先生治病,不出乎气、血、痰,故用药之要有三:气用四君子汤,血用四物汤,痰用二陈汤。久病属郁,立治郁之方,曰越鞠丸。」

"Master Danxi's treatment of disease never departed from Qi, Blood, and Phlegm. Thus his essential medicines were three: Four Gentlemen Decoction for Qi, Four Substances Decoction for Blood, Two Matured Ingredients Decoction for Phlegm. For chronic illness belonging to stagnation, he established a formula to treat stagnation, called Yue Ju Wan."

Historical Context

How Yue Ju Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Yue Ju Wan was created by Zhu Danxi (朱丹溪, 1281–1358), one of the four great masters of the Jin-Yuan medical era. Its source text is the Dan Xi Xin Fa (《丹溪心法》, "Erta and Methods of [Zhu] Danxi"), recorded in the chapter on the Six Stagnations (六郁). The formula's name literally means "to surmount" or "to release" (越) that which is "bound up" or "restrained" (鞠/郁). It is also known as Qiong Zhu Wan (芎术丸, "Chuanxiong and Atractylodes Pill") in the same text.

Zhu Danxi's creation of this formula was a direct expression of his influential "Six Stagnations" (六郁) theory, which held that stagnation of Qi, Blood, Dampness, Phlegm, Fire, and Food are the root causes of most internal diseases. His student Wang Lun later summarized Danxi's entire clinical approach as centering on Qi, Blood, Phlegm, and Stagnation, with Yue Ju Wan as the definitive formula for the last category. A notable feature of its design is that five herbs address six types of stagnation, with no dedicated herb for Phlegm. This reflects Zhu Danxi's principle of "treating the root": once Qi flows, Dampness is resolved, and food is digested, the conditions that generate Phlegm are eliminated and it resolves on its own.

In modern times, Yue Ju Wan has attracted significant scientific interest for its potential antidepressant effects, with researchers noting that the classical concept of "yu zheng" (stagnation syndrome) overlaps considerably with the modern understanding of depressive disorders. It remains listed in the Pharmacopoeia of the People's Republic of China as a non-prescription medicine.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Yue Ju Wan

1

Yueju Pill Rapidly Induces Antidepressant-Like Effects and Acutely Enhances BDNF Expression in Mouse Brain (Preclinical study, 2013)

Xue W, Zhou X, Yi N, et al. Evidence-Based Complementary and Alternative Medicine, 2013, Volume 2013, Article ID 184367.

This was the first study to demonstrate rapid antidepressant-like effects from an herbal medicine. Acute administration of Yue Ju Wan extract in mice rapidly reduced depressive-like behavior in the learned helplessness paradigm, with effects sustained for at least 24 hours. The formula also rapidly increased BDNF (brain-derived neurotrophic factor) expression in the hippocampus, a mechanism similar to ketamine.

PubMed
2

A Role of Yueju in Fast-Onset Antidepressant Action on Major Depressive Disorder and Serum BDNF Expression: A Randomly Double-Blind, Fluoxetine-Adjunct, Placebo-Controlled, Pilot Clinical Study (RCT, 2015)

Wu R, Zhu D, Xia Y, et al. Neuropsychiatric Disease and Treatment, 2015, Volume 11, Pages 2013-2021.

This small double-blind, placebo-controlled pilot RCT enrolled MDD patients who received either Yue Ju Wan plus fluoxetine or placebo plus fluoxetine for 7 days. The Yue Ju Wan group showed significant improvement in depression scores (HDRS-24) from day 3 onward, while the placebo group did not improve during this period. The study provided preliminary clinical evidence for relatively rapid antidepressant effects of Yue Ju Wan as an adjunct therapy.

3

Rapid Antidepressant Effects of Yueju: A New Look at the Function and Mechanism of an Old Herbal Medicine (Review, 2017)

Xue W, Chen G, et al. Journal of Ethnopharmacology, 2017, Volume 203, Pages 226-232.

This comprehensive review synthesized preclinical and clinical evidence for Yue Ju Wan's rapid antidepressant effects. It compared Yue Ju Wan's mechanisms to ketamine, noting shared neuroplasticity pathways as well as mechanisms unique to Yue Ju Wan, including PKA-CREB-BDNF signaling. Gardenia jasminoides (Zhi Zi) was identified as the key constituent herb responsible for the rapid antidepressant activity.

4

Efficiency and Safety of Yueju Antidepressant for Primary Depression Patients: A Meta-Analysis of Randomized Controlled Trials (Meta-analysis, 2020)

Yu YH, Song HY, Liu JG, Wang PL, Wang CL. Journal of Traditional Chinese Medical Sciences, 2020.

This systematic review and meta-analysis of multiple RCTs found that Yue Ju Wan-based formulas were significantly superior to conventional antidepressants alone in clinical efficiency and HAMD score reduction. Side effects were relatively mild (headache, dizziness, thirst) and fewer than with SSRIs alone. Key pharmacological ingredients identified included genipin, tetramethylpyrazine, and ferulic acid.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.