Qing Ying Tang

Clear the Nutritive Level Decoction · 清營湯

Also known as: Clear the Ying Level Decoction

A classical formula for serious febrile (feverish) illnesses where Heat has penetrated deep into the body, causing high fever that worsens at night, restlessness, disturbed sleep, and sometimes delirium. It works by clearing deep-seated Heat, protecting the body's fluids from being dried out, and guiding the pathogenic Heat back outward where the body can expel it more easily.

Origin Wen Bing Tiao Bian (温病条辨, Systematic Differentiation of Warm Diseases) by Wu Jutong (吴鞠通) — Qīng dynasty, 1798 CE
Composition 9 herbs
Shui Niu Jiao
King
Shui Niu Jiao
Shu Di Huang
Deputy
Shu Di Huang
Xuan Shen
Deputy
Xuan Shen
Mai Dong
Deputy
Mai Dong
Jin Yin Hua
Assistant
Jin Yin Hua
Lian Qiao
Assistant
Lian Qiao
Dan Zhu Ye
Assistant
Dan Zhu Ye
Huang Lian
Assistant
Huang Lian
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qing Ying Tang is designed to correct these specific patterns.

Why Qing Ying Tang addresses this pattern

This is the primary pattern for Qing Ying Tang. When warm-Heat pathogenic factors penetrate from the Qi level into the deeper Ying (nutritive) level, they lodge in the Yin aspect of the body and disturb the Heart spirit. The Heat intensifies at night because nighttime is when the body's Yang naturally moves inward to the Yin level, where it encounters and amplifies the trapped Heat. The formula's King herb (Shui Niu Jiao) directly clears the Heat-toxins from the Ying level, while the three Deputies (Sheng Di Huang, Xuan Shen, Mai Dong) replenish the Yin fluids being scorched by the Heat. Crucially, Jin Yin Hua, Lian Qiao, and Zhu Ye Xin provide an exit route for the pathogenic Heat to vent back outward to the Qi level, embodying the famous Warm Disease principle of 'venting Heat to redirect it to the Qi level' (透热转气). Huang Lian drains Heart Fire directly, while Dan Shen cools and moves the Blood to prevent stasis.

A practitioner would look for one or more of these signs

Fever

High fever that worsens at night (身热夜甚)

Insomnia

Restlessness with difficulty sleeping (神烦少寐)

Delirium

Occasional delirious speech (时有谵语)

Skin Rashes

Faint, early-stage skin rashes (斑疹隐隐)

Dry Mouth

Thirst or paradoxically no thirst (口渴或不渴)

Red Tongue

Deep red (crimson/绛) tongue that is dry

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Qing Ying Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM understands viral encephalitis as a Warm-Heat pathogen (温热邪气) that has penetrated deep into the body from the superficial defense and Qi levels to reach the Ying (nutritive) and Blood levels. The brain, which houses the spirit (神, shen), is closely connected to the Heart system in TCM theory. When intense Heat invades the Ying level and the Pericardium, it disrupts the Heart's role of housing consciousness and spirit, producing the high fever, mental confusion, restlessness, and potential coma that characterize encephalitis. The Heat also scorches and depletes Yin fluids, which further destabilizes the spirit. In severe cases, the Heat may stir internal Liver Wind, producing convulsions and seizures.

Why Qing Ying Tang Helps

Qing Ying Tang directly addresses the core TCM mechanism of encephalitis by clearing Heat from the Ying level and Pericardium. Shui Niu Jiao powerfully clears Heat-toxins from the Blood and nutritive level while also calming the spirit. Huang Lian drains Fire from the Heart, directly addressing the agitation and delirium. The Yin-nourishing Deputies (Sheng Di Huang, Xuan Shen, Mai Dong) protect the body's fluids from further damage by the intense fever. Jin Yin Hua and Lian Qiao resolve toxins and help vent Heat outward. In clinical practice, this formula is frequently combined with An Gong Niu Huang Wan when consciousness is significantly impaired, or modified with Gou Teng and Ling Yang Jiao when convulsions develop.

Also commonly used for

Meningitis

Epidemic cerebrospinal meningitis (流行性脑脊髓膜炎) with Ying-level Heat signs

Typhoid And Paratyphoid Fever

Enteric fever (肠伤寒) with persistent fever and delirium

Pneumonia

Severe pneumonia with high fever worsening at night and Ying-level signs

Fever

Other acute febrile infectious diseases when the pattern matches Heat entering the Ying level

What This Formula Does

Every TCM formula has a specific set of actions — here's what Qing Ying Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Qing Ying Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Qing Ying Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Qing Ying Tang works at the root level.

Qing Ying Tang addresses the critical moment in a febrile illness when pathogenic Heat breaks through the Qi level (the body's outer defensive layers) and sinks into the Ying (Nutritive) level, the deeper functional layer closely associated with Blood and the Heart. The Ying level circulates nourishment through the blood vessels, and when scorching Heat lodges here, it simultaneously damages the body's Yin fluids and disturbs the Heart spirit.

Because the Ying level belongs to Yin and is most active at night, fever characteristically worsens after dark. The Heat agitates the Heart, producing restlessness, insomnia, and even delirious muttering. The tongue turns deep crimson red (绛) as Heat scorches the Ying, and it becomes dry as fluids are consumed. A telling paradox may appear: the patient is expected to be thirsty (Heat normally dries fluids), yet feels no thirst, because the Heat is trapped deep in the Ying level where it steams fluids upward to moisten the throat without truly quenching the body's deeper dehydration. Faint skin eruptions (斑疹隐隐) may begin to appear, signalling that Heat is starting to force Blood out of the vessels.

This pattern sits at a pivotal crossroads: if left unchecked, Heat will advance further into the Blood level, causing hemorrhaging and severe delirium. But because the pathogen has only recently entered the Ying level, there remains an opportunity to reverse its course. Ye Tianshi's famous principle, "when Heat enters the Ying level, one can still vent Heat back to the Qi level" (入营犹可透热转气), captures this window of therapeutic opportunity. The formula simultaneously cools the Ying level from within, vents Heat outward toward the Qi level, protects the Yin fluids being consumed by the Heat, and prevents Blood stasis from forming as Heat thickens the Blood.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter and sweet with salty notes. Bitter to clear Heat and drain Fire, sweet to nourish Yin and generate fluids, salty (from Water Buffalo horn) to enter the Blood level and soften hardness.

Channels Entered

Ingredients

9 herbs

The herbs that make up Qing Ying Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Shui Niu Jiao

Shui Niu Jiao

Water buffalo horn

Dosage 30 - 60g (Shui Niu Jiao); original Xi Jiao dose was 9g (3 qian)
Temperature Cold
Taste Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Heart, Liver, Stomach
Preparation Shui Niu Jiao should be shaved or powdered and decocted first (先煎) for at least 30 minutes before adding other herbs.

Role in Qing Ying Tang

The chief herb of the formula. Salty and cold, it enters the Heart and Liver channels to powerfully clear Heat from the nutritive (Ying) level and Blood, resolve toxins, and cool the Blood to prevent rashes from worsening. It directly targets the core problem of intense Heat lodged deep in the body.
Deputies — Assists and enhances the King
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 15g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Qing Ying Tang

Cools the Blood and nourishes Yin. Works alongside the King herb to clear Heat from the Blood level while replenishing the fluids that the intense Heat has damaged. Its sweet, cold nature helps protect the body's Yin (the cooling, moistening substances).
Xuan Shen

Xuan Shen

Ningpo figwort root

Dosage 9g
Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Lungs, Stomach, Kidneys

Role in Qing Ying Tang

Nourishes Yin, descends Fire, and resolves toxins. Reinforces both the Heat-clearing and Yin-nourishing actions of the formula, helping to cool the Blood and protect the throat and body fluids.
Mai Dong

Mai Dong

Ophiopogon root

Dosage 9g
Temperature Slightly Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, Stomach

Role in Qing Ying Tang

Clears Heat from the Heart, nourishes Yin, and generates fluids. Together with Sheng Di Huang and Xuan Shen, these three Deputies form a trio that powerfully protects and replenishes the body's Yin and fluids, assisting the King herb in clearing Heat from the nutritive level.
Assistants — Supports or moderates other herbs
Jin Yin Hua

Jin Yin Hua

Honeysuckle flower

Dosage 9g
Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Lungs, Heart, Stomach, Large Intestine

Role in Qing Ying Tang

Light, aromatic, and outward-moving in nature. Clears Heat and resolves toxins while helping to 'vent Heat back to the Qi level' (透热转气), giving the deep-seated pathogenic Heat a pathway outward so it can be expelled from the body. This embodies Ye Tianshi's principle that Heat in the Ying level can still be redirected outward.
Lian Qiao

Lian Qiao

Forsythia fruit

Dosage 6g
Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Heart, Small Intestine
Preparation Use with the heart (seed) intact (连心用).

Role in Qing Ying Tang

Works alongside Jin Yin Hua to clear Heat, resolve toxins, and vent pathogenic Heat outward from the nutritive level to the Qi level. Its light, dispersing nature helps create an exit route for the trapped Heat. The heart (seed) of Lian Qiao is specifically included for its ability to clear Heart Heat.
Dan Zhu Ye

Dan Zhu Ye

Lophatherum

Dosage 3g
Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Stomach, Small Intestine

Role in Qing Ying Tang

Light and cooling, it clears Heat from the Heart and assists Jin Yin Hua and Lian Qiao in venting Heat outward from the nutritive level. 'Zhu Ye Xin' specifically refers to the tender rolled inner leaves of bamboo, which are lighter and more suitable for clearing upper-body Heat than mature bamboo leaves.
Huang Lian

Huang Lian

Coptis rhizome

Dosage 5g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen

Role in Qing Ying Tang

Bitter and cold, it powerfully drains Fire from the Heart. Since the Heart governs the Blood and the Ying (nutritive) level is closely connected to the Heart, Huang Lian directly clears the Heart Fire that causes restlessness, insomnia, and delirium.
Dan Shen

Dan Shen

Red sage root

Dosage 6g
Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Pericardium

Role in Qing Ying Tang

Clears Heat from the Heart and cools the Blood, while also gently invigorating Blood circulation. This prevents the pathogenic Heat from 'bonding' with the Blood and causing Blood stasis, a dangerous complication where Heat and stagnant Blood combine. It also helps counteract the potential for the formula's many cold herbs to slow Blood flow excessively.

Why This Combination Works

How the herbs in Qing Ying Tang complement each other

Overall strategy

This formula addresses Heat that has penetrated from the superficial Qi level into the deeper nutritive (Ying) level. The strategy has three prongs: clear the intense Heat from the Ying level directly, replenish the Yin fluids being consumed by the Heat, and create a pathway for the Heat to vent back outward to the Qi level where it can be resolved. This last strategy embodies the famous principle from Ye Tianshi: when Heat enters the Ying level, it can still be redirected back to the Qi level (入营犹可透热转气).

King herb

Shui Niu Jiao (water buffalo horn, substituting the original Xi Jiao/rhinoceros horn) is the sole King. Salty and cold, it enters the Heart and directly clears Heat-toxins from the nutritive level and Blood. Its salty flavour gives it the ability to penetrate deeply and soften hardness, while its cold nature directly opposes the pathogenic Heat. As the highest-dose ingredient, it anchors the entire formula.

Deputy herbs

Sheng Di Huang, Xuan Shen, and Mai Dong form the Deputy group. These three sweet, cold herbs nourish Yin, generate fluids, and cool the Blood. They serve a dual purpose: they reinforce the King herb's Heat-clearing action while simultaneously protecting and replenishing the body's Yin substances that the intense Heat is consuming. Together they ensure that clearing Heat does not come at the cost of further depleting the patient's already-damaged fluids. This trio is essentially the composition of Zeng Ye Tang (Increase Fluids Decoction), reflecting the formula's deep concern for preserving Yin.

Assistant herbs

Five herbs serve as Assistants, divided into two functional groups. The first group consists of Jin Yin Hua, Lian Qiao, and Zhu Ye Xin. These are light, aromatic, outward-dispersing herbs that clear Heat and resolve toxins at the Qi level. Their crucial role is 'venting Heat outward' (透热转气): they give the deep-seated nutritive-level Heat an exit route back to the more superficial Qi level, from where the body can expel it. Without these herbs, the formula would only suppress Heat in place rather than actively expelling it. The second group consists of Huang Lian and Dan Shen. Huang Lian, bitter and cold, directly drains Fire from the Heart, addressing the restlessness and delirium caused by Heat disturbing the Heart spirit. Dan Shen cools the Blood and gently moves it, preventing the dangerous complication of Heat binding with stagnant Blood and ensuring that the many cold, Yin-nourishing herbs in the formula do not inadvertently slow Blood circulation to the point of stasis.

Notable synergies

The pairing of Shui Niu Jiao with Sheng Di Huang is central. Shui Niu Jiao clears Heat-toxins from the Blood while Sheng Di Huang cools and nourishes the Blood, creating a powerful combination that addresses both the cause (Heat) and the consequence (Yin damage). The trio of Jin Yin Hua, Lian Qiao, and Zhu Ye Xin represents a distinctive feature of this formula. Their light, outward-moving nature complements the heavy, inward-directed Heat-clearing of the King and Deputies. The overall formula thus combines salty-cold herbs (to clear deep Heat) with sweet-cold herbs (to nourish Yin) and light-aromatic herbs (to vent Heat outward), creating a comprehensive three-dimensional treatment strategy that is considered a hallmark of Wu Jutong's prescribing genius.

How to Prepare

Traditional preparation instructions for Qing Ying Tang

Prepare as a decoction. Use 8 cups of water. If using Shui Niu Jiao (water buffalo horn) shavings as the modern substitute for Xi Jiao (rhinoceros horn), decoct the horn shavings first for 30 minutes before adding the remaining herbs. Bring to a boil, then simmer until reduced to 3 cups. Divide into 3 doses and take warm throughout the day.

Note: Lian Qiao should be used with its heart (seed) intact (连心用, lián xīn yòng), and Zhu Ye Xin refers specifically to the tender rolled inner leaves of bamboo, not ordinary bamboo leaves.

Common Modifications

How practitioners adapt Qing Ying Tang for specific situations

Removed
Huang Lian

Its bitter, drying nature can further damage Yin fluids in severe Yin deficiency

This is explicitly described in the Wen Bing Tiao Bian. When Yin damage is severe, Huang Lian's bitter and drying properties can worsen the fluid depletion, so it is removed to protect the remaining Yin.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Qing Ying Tang should not be used or requires extra caution

Avoid

Tongue coating that is white and slippery (舌白滑). Wu Jutong explicitly warns in the original text: 'If the tongue is white and slippery, do not give this formula.' His self-commentary explains that a white, slippery tongue indicates not only severe Heat but also heavy Dampness, and the moistening, Yin-nourishing herbs in the formula would trap Dampness and retain the pathogen.

Avoid

Cold patterns or Yang deficiency. This is a strongly cold formula designed for excess Heat in the Ying level. It should not be used when the patient shows true Cold signs such as cold limbs, pale tongue, and slow pulse.

Caution

Spleen and Stomach deficiency with poor digestion. The cold and Yin-nourishing nature of herbs like Sheng Di Huang, Xuan Shen, and Mai Dong can burden a weak digestive system and generate Dampness.

Caution

Heat confined entirely to the Qi level with no signs of Ying-level involvement. If fever is high but the tongue is yellow-coated rather than deep red (绛), Qi-level clearing formulas like Bai Hu Tang are more appropriate.

Caution

Heat that has fully entered the Blood level with active bleeding, macular rashes, or hematemesis. At that stage, a stronger Blood-cooling formula like Xi Jiao Di Huang Tang is needed instead.

Caution

Pregnancy. The formula contains Dan Shen (Salvia root), which invigorates Blood and could theoretically affect uterine blood flow. Use only under close professional supervision if absolutely necessary.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Dan Shen (Salvia miltiorrhiza) in this formula actively invigorates Blood circulation, which carries a theoretical risk of stimulating uterine blood flow. Sheng Di Huang (raw Rehmannia) is very cold in nature and could be taxing on a pregnant woman's digestive system. Huang Lian (Coptis) is also strongly cold and bitter. While the formula targets acute, life-threatening febrile illness where withholding treatment may itself be dangerous, it should only be used in pregnancy when the clinical situation truly demands it, under careful professional supervision, and with appropriate dose adjustments.

Breastfeeding

There is limited specific data on the safety of Qing Ying Tang during breastfeeding. The formula is strongly cold in thermal nature and contains multiple bitter and cold herbs (Huang Lian, Shui Niu Jiao, Sheng Di Huang) whose compounds could theoretically transfer into breast milk and cause loose stools or digestive upset in the nursing infant. Dan Shen's Blood-invigorating properties also warrant caution. However, this formula is designed for acute, serious febrile illness, and if the nursing mother is severely ill with Ying-level Heat, the clinical need typically outweighs theoretical breastfeeding concerns. If used, the infant should be monitored for changes in feeding, stool consistency, or temperament. Consult a qualified practitioner.

Children

Qing Ying Tang can be used in pediatric patients when the pattern clearly matches Ying-level Heat, but dosage must be substantially reduced according to the child's age and body weight. A common approach is to use one-third to one-half of the adult dose for children over 6, and one-quarter for younger children. Children with febrile illness can deteriorate rapidly, and Ying-level Heat in children is a serious condition requiring prompt professional attention. The strongly cold and Yin-nourishing nature of this formula can burden a child's immature digestive system, so practitioners should watch for diarrhea or loss of appetite. In modern clinical practice, this formula has been used in pediatric cases of viral encephalitis and severe infectious fevers under specialist supervision.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Qing Ying Tang

Anticoagulant and antiplatelet medications: Dan Shen (Salvia miltiorrhiza root) in this formula has well-documented Blood-invigorating properties. Its active compound tanshinone and related components may potentiate the effects of warfarin, heparin, aspirin, or clopidogrel, increasing the risk of bleeding. Concurrent use requires close monitoring of INR and bleeding signs.

Antihypertensive drugs: Dan Shen has known vasodilatory effects and may enhance the blood-pressure-lowering effects of antihypertensive medications, potentially causing hypotension.

Digoxin and cardiac glycosides: Sheng Di Huang (raw Rehmannia) contains iridoid glycosides that could theoretically interact with cardiac glycosides. Caution is advised if the patient is on digoxin therapy.

Immunosuppressant medications: Given the formula's demonstrated immunomodulatory effects (particularly on Th17 pathways and inflammatory cytokines), it could theoretically interfere with immunosuppressive drug regimens. Patients on post-transplant medications or biologics for autoimmune conditions should exercise caution.

Usage Guidance

Practical advice for getting the most out of Qing Ying Tang

Best time to take

Three times daily between meals. In acute febrile illness with Ying-level Heat, the classical instruction is to decoct and take three doses spread evenly throughout the day and evening.

Typical duration

Acute use: typically 3-7 days, reassessed daily as this treats a rapidly evolving febrile condition.

Dietary advice

While taking this formula, avoid greasy, fried, and rich foods that generate internal Heat and Dampness, as these can trap the pathogen and worsen the condition. Spicy, warming foods such as chili, ginger, garlic, lamb, and alcohol should be strictly avoided since they add Heat to an already Heat-dominated pattern. Light, cooling, and easily digestible foods are preferred: congee (rice porridge), mung bean soup, watermelon, pear, and cucumber support the formula's Heat-clearing and Yin-nourishing actions. Adequate hydration with room-temperature or slightly cool water is important to support fluid recovery. If the patient's appetite is poor (common in acute febrile illness), do not force food. Small, frequent sips of thin porridge are sufficient.

Qing Ying Tang originates from Wen Bing Tiao Bian (温病条辨, Systematic Differentiation of Warm Diseases) by Wu Jutong (吴鞠通) Qīng dynasty, 1798 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Qing Ying Tang and its clinical use

From the Wen Bing Tiao Bian (《温病条辨》) by Wu Jutong (吴鞠通)

Original (Upper Burner, Article 15):
「太阴温病,寸脉大,舌绛而干,法当渴,今反不渴者,热在营中也,清营汤去黄连主之。」

Translation: In Taiyin warm disease, when the cun pulse is large, the tongue is deep red and dry, and one would expect thirst but there is paradoxically no thirst, the Heat is in the Ying (Nutritive) level. Treat with Qing Ying Tang minus Huang Lian.

Original (Upper Burner, Summer-Heat chapter):
「脉虚夜寐不安,烦渴舌赤,时有谵语,目常开不闭,或喜闭不开,暑入手厥阴也。手厥阴暑温,清营汤主之。」

Translation: When the pulse is deficient, sleep at night is restless, there is irritability and thirst with a red tongue, intermittent delirious speech, and the eyes are either constantly open or prefer to remain shut, Summer-Heat has entered the Hand Jueyin (Pericardium). For Hand Jueyin Summer-Heat warm disease, Qing Ying Tang governs.

Wu Jutong's warning on tongue diagnosis:
「舌白滑者,不可与也。舌白滑,不惟热重,湿亦重矣,湿重忌柔润药。」

Translation: If the tongue is white and slippery, this formula must not be given. A white, slippery tongue indicates not only severe Heat but also heavy Dampness. When Dampness is heavy, soft moistening herbs are contraindicated.

Related classical principle from Ye Tianshi (叶天士)

「入营犹可透热转气。」

Translation: When Heat has entered the Ying level, one may still vent (透) the Heat back out to the Qi level. This principle forms the strategic backbone of Qing Ying Tang's design.

Historical Context

How Qing Ying Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Qing Ying Tang was created by Wu Jutong (吴鞠通, also known as Wu Tang, 1758-1836), one of the four great masters of the Warm Disease (Wen Bing) school of Chinese medicine. He published this formula in his landmark text Wen Bing Tiao Bian (《温病条辨》, Systematic Differentiation of Warm Diseases), which was first printed in 1813 during the Qing Dynasty. Wu developed the formula after years of personal tragedy and study: his father died of a warm disease, and his nephew later died of a febrile illness that attending physicians mismanaged by using cold-damage (Shang Han) methods inappropriate for warm diseases. These losses drove Wu to devote himself to developing a systematic approach to warm febrile illness.

The formula is a direct clinical embodiment of the principle articulated by the slightly earlier Warm Disease master Ye Tianshi (叶天士, 1667-1746): "When Heat enters the Ying level, one can still vent Heat back to the Qi level" (入营犹可透热转气). Wu's genius was in translating this theoretical principle into a precise herbal prescription. The original formula used Rhinoceros horn (Xi Jiao 犀角) as the chief herb, but following the international ban on rhinoceros products due to conservation concerns, Water Buffalo horn (Shui Niu Jiao 水牛角) is universally used as a substitute, though at a much larger dose (typically 30g compared to the original 9g of Xi Jiao). Wu also designed the formula with a poetic touch: the original instructions specified using the "hearts" of several ingredients (bamboo leaf hearts, lotus seed hearts in Lian Qiao), reflecting the principle that "heart enters Heart" to target the Pericardium and clear Heat from the deepest emotional and spiritual center of the body.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Qing Ying Tang

1

Post-treatment With Qing-Ying-Tang Relieves Lipopolysaccharide-Induced Cerebral Microcirculation Disturbance in Mice (Preclinical Study, 2019)

Wang H-M, Huang P, Li Q, Yan L-L, Sun K, Yan L, Pan C-S, Wei X-H, Liu Y-Y, Hu B-H, Wang C-S, Fan J-Y, Han J-Y. Frontiers in Physiology, 2019, 10:1320.

This study from Peking University Health Science Center investigated the effects of Qing Ying Tang on brain microcirculation damage caused by bacterial endotoxin (LPS) in mice. The formula was found to ameliorate cerebral microvascular dysfunction and attenuate inflammatory cytokine increases in brain tissue, providing a potential mechanism for its traditional use in febrile diseases with neurological disturbance (delirium, restlessness).

2

Qing Ying Tang Ameliorates the Severity of Acute Lung Injury Induced by Severe Acute Pancreatitis in Rats via the Upregulation of Aquaporin-1 (Preclinical Study, 2014)

Gao Z, Xu J, Sun D, Zhang R, Liang R, Wang L, Fan R. Experimental and Therapeutic Medicine, 2014, 8(6): 1819-1824.

This animal study examined the effects of Qing Ying Tang on acute lung injury secondary to severe acute pancreatitis in rats. The formula significantly reduced lung tissue edema and improved lung pathology, with the mechanism linked to upregulation of aquaporin-1, a water transport protein in lung endothelial cells. The findings suggest a possible mechanism for the formula's ability to address fluid dysregulation during severe systemic inflammation.

PubMed
3

Clinical Efficacy and Mechanism of Qingying Tang for Treating Psoriatic Blood-Heat Syndrome Based on IL-23/Th17 Pathway (RCT, 2019)

Published in Zhongguo Zhong Yao Za Zhi (China Journal of Chinese Materia Medica), 2019.

This randomized controlled trial enrolled 72 patients with psoriasis classified as Blood-Heat pattern, comparing Qing Ying Tang against Acitretin Capsules over 12 weeks. The formula group showed improvements in psoriasis severity scores (PASI) and quality of life measures (DLQI). Mechanistically, Qing Ying Tang was found to modulate the IL-23/Th17 inflammatory pathway, reducing peripheral blood Th17 cell percentages, offering insight into its anti-inflammatory mechanism from a modern immunological perspective.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.