Xi Jiao Di Huang Tang

Rhinoceros Horn and Rehmannia Decoction · 犀角地黃湯

Also known as: Qing Re Di Huang Tang (清热地黄汤), Rhinoceros Horn and Rehmannia Decoction

A classical emergency formula used when severe internal Heat has entered the Blood, causing abnormal bleeding (nosebleeds, vomiting blood, blood in stool or urine), dark purple skin discolouration, high fever, and mental confusion or agitation. It works by powerfully cooling the Blood, clearing Heat toxins, nourishing depleted body fluids, and dispersing blood clots that form when Heat scorches the Blood. Originally using rhinoceros horn, modern versions substitute water buffalo horn.

Origin Bei Ji Qian Jin Yao Fang (備急千金要方) — Táng dynasty, ~652 CE
Composition 4 herbs
Shui Niu Jiao
King
Shui Niu Jiao
Shu Di Huang
Deputy
Shu Di Huang
Chi Shao
Assistant
Chi Shao
Mu Dan Pi
Assistant
Mu Dan Pi
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Xi Jiao Di Huang Tang is designed to correct these specific patterns.

Why Xi Jiao Di Huang Tang addresses this pattern

This is the primary pattern addressed by this formula. When pathogenic Heat penetrates deep into the Blood level, it produces three categories of disturbance: it agitates the Heart spirit (causing delirium and mania-like behaviour), it forces Blood out of the vessels recklessly (causing various types of bleeding and skin eruptions), and it scorches Yin fluids, thickening the Blood and leading to stasis. Shui Niu Jiao directly enters the Blood level to clear Heat and calm the spirit. Sheng Di Huang cools the Blood while replenishing the Yin that Heat has consumed. Chi Shao and Mu Dan Pi clear residual Heat from the Blood while actively dispersing the stasis that invariably accompanies Blood-level Heat. The formula thus addresses all three consequences of Heat in the Blood simultaneously.

A practitioner would look for one or more of these signs

Hematemesis

Vomiting blood due to Heat forcing Blood upward out of the vessels

Nosebleeds

Nosebleeds from Heat damaging the upper Blood vessels

Dark Blood In Stool

Dark or black stool indicating Heat-driven bleeding in the lower body

Blood In Urine

Blood in the urine from Heat damaging the lower Blood vessels

Skin Rashes

Dark purple-black macules (Ban) on the skin from Blood extravasating into the tissues

Delirium

Delirious speech or mania-like agitation from Heat disturbing the Heart spirit

Fever

High fever with a deep crimson tongue that has raised prickles

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Xi Jiao Di Huang Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Heat in the Blood

TCM Interpretation

In TCM, purpura with red or purple spots on the skin is understood as Heat toxins invading the Blood level and forcing Blood out of the vessels into the skin and tissues. The purple discolouration reflects Blood that has left its normal pathways. When accompanied by fever, a red or crimson tongue, and a rapid pulse, this clearly points to a Heat-in-the-Blood pattern. The bleeding is not from structural weakness but from Heat "pushing" Blood recklessly. In children, the condition may also involve the Stomach and intestines (abdominal pain, bloody stool) or the Kidneys (blood in urine), all understood as Heat damaging Blood vessels in those areas.

Why Xi Jiao Di Huang Tang Helps

Xi Jiao Di Huang Tang directly targets the root mechanism: Shui Niu Jiao clears the Heat toxins from the Blood level, stopping the force that drives Blood out of the vessels. Sheng Di Huang cools the Blood and nourishes the Yin fluids that Heat has depleted, helping the body recover. Chi Shao and Mu Dan Pi cool any remaining Heat in the Blood while dispersing the extravasated Blood that has already formed the purpuric lesions, promoting the resolution of existing spots while preventing new ones.

Also commonly used for

Acute Leukemia

When presenting with bleeding, fever, and Blood-Heat signs

Hepatitis

Acute severe hepatitis or hepatic coma with Blood-Heat pattern

Uremia

With bleeding tendency and signs of Blood-level Heat

Purpura

With widespread bleeding and Heat signs

Nosebleeds

Recurrent or severe epistaxis due to Blood Heat

Hematemesis

Vomiting of blood due to Heat damaging blood vessels

Lupus

Systemic lupus erythematosus with Blood-Heat manifestations

What This Formula Does

Every TCM formula has a specific set of actions — here's what Xi Jiao Di Huang Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Xi Jiao Di Huang Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Xi Jiao Di Huang Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Xi Jiao Di Huang Tang works at the root level.

Xi Jiao Di Huang Tang addresses a critical stage in the progression of febrile (Heat) disease: the deepest penetration of pathogenic Heat into the Blood level (血分, xue fen). In the Warm Disease (Wen Bing) framework, Heat can progress inward through four stages — Defensive (Wei), Qi, Nutritive (Ying), and Blood (Xue). This formula targets the most severe stage, where Heat has fully invaded the Blood.

When intense Heat enters the Blood level, it produces three overlapping types of damage. First, because the Heart governs Blood and houses the spirit (shen), Heat in the Blood disturbs the mind, causing restlessness, delirium, and in severe cases manic behavior. Second, Heat forces Blood out of its normal channels — it "drives the Blood recklessly" (迫血妄行). Blood that overflows upward causes vomiting of blood and nosebleeds; blood that spills downward causes bloody stool and urine; blood that leaks into the skin produces dark purplish rashes (斑, ban). Third, extreme Heat scorches the fluids within the Blood, thickening it and causing stagnation. This stagnant Blood (瘀血) combines with Heat to form a vicious cycle: the tongue becomes deep crimson and dry, stools turn black, and the person may swish water in the mouth but not want to swallow it (because the Heat sits deep in the Yin level, steaming fluids upward to the mouth).

The key therapeutic challenge is threefold: Heat must be cleared or the Blood will never calm; stagnant Blood must be dispersed or it will accumulate and cause further harm; and Yin must be replenished or the Fire will never be extinguished. As the Qing dynasty physician Ye Tianshi famously stated: "Once Heat enters the Blood, one must directly cool the Blood and disperse the Blood." This formula answers all three needs simultaneously.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter and sweet with a salty undertone — bitter to clear Heat, sweet to nourish Yin and Blood, salty to enter the Blood level and soften hardness.

Ingredients

4 herbs

The herbs that make up Xi Jiao Di Huang Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Shui Niu Jiao

Shui Niu Jiao

Water buffalo horn

Dosage 30 - 60g
Temperature Cold
Taste Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Heart, Liver, Stomach
Preparation Shaved into thin slices (镑片) and decocted first for 20-30 minutes before adding other herbs

Role in Xi Jiao Di Huang Tang

The chief herb of the formula. Salty and cold, it enters directly into the Blood level to clear the Heart, cool the Blood, and resolve Heat toxins. It calms the Blood so that bleeding stops and the mind clears. Originally rhinoceros horn (Xi Jiao) was used, but water buffalo horn (Shui Niu Jiao) is now the standard substitute.
Deputy — Assists and enhances the King
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 15 - 30g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Xi Jiao Di Huang Tang

Assists the King herb in clearing Heat and cooling the Blood. It also nourishes Yin and generates fluids, which is critical because intense Blood-level Heat severely depletes the body's Yin fluids. This dual action of clearing Heat while replenishing what Heat has consumed makes it an essential complement to Shui Niu Jiao.
Assistants — Supports or moderates other herbs
Chi Shao

Chi Shao

Red peony root

Dosage 9 - 15g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver

Role in Xi Jiao Di Huang Tang

Cools the Blood and disperses Blood stasis. When intense Heat enters the Blood, the Blood thickens and tends to clot. Chi Shao prevents this stagnation from forming while reinforcing the Blood-cooling action of the King and Deputy herbs. The original text uses the name Shao Yao (芍药), which in this Blood-Heat context is understood as Chi Shao (red peony root).
Mu Dan Pi

Mu Dan Pi

Tree peony root bark

Dosage 6 - 12g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys

Role in Xi Jiao Di Huang Tang

Cools the Blood and disperses stasis that has already formed. Mu Dan Pi is uniquely suited here because it can break up extravasated Blood (Blood that has leaked out of the vessels) without accelerating Blood flow or worsening bleeding. Together with Chi Shao, it ensures that while Heat is cleared and Blood is cooled, old stasis does not linger.

Why This Combination Works

How the herbs in Xi Jiao Di Huang Tang complement each other

Overall strategy

This formula addresses the critical situation where pathogenic Heat has penetrated deep into the Blood level, causing bleeding, mental disturbance, and Blood stasis. The treatment principle follows Ye Tianshi's famous teaching: when Heat enters the Blood, one must cool the Blood and disperse stasis simultaneously. The formula achieves this through four herbs that clear Heat toxins, cool Blood, nourish depleted Yin, and prevent or resolve stasis.

King herbs

Shui Niu Jiao (water buffalo horn, replacing the original Xi Jiao) is salty, bitter, and cold, entering directly into the Blood level. It clears Heart Fire, resolves toxic Heat, and cools the Blood. By calming the Heart, it addresses the mental disturbance (delirium, mania-like agitation) caused by Heat harassing the spirit. Importantly, despite its cold nature, it does not congeal the Blood, making it especially suited for Blood-level Heat conditions where stasis is a concern.

Deputy herbs

Sheng Di Huang (raw Rehmannia root) is sweet, bitter, and cold. It reinforces the King herb's Blood-cooling action while adding a crucial dimension: nourishing Yin and generating fluids. Because Blood-level Heat consumes Yin fluids and depletes the blood itself, Sheng Di Huang replenishes what has been lost. This combination of clearing and replenishing is essential for preventing further damage.

Assistant herbs

Chi Shao (red peony root) and Mu Dan Pi (moutan bark) both cool the Blood and disperse stasis, functioning as reinforcing assistants. Chi Shao cools and invigorates the Blood, preventing the cold nature of the other herbs from causing excessive congealing. Mu Dan Pi is particularly valued because it disperses extravasated Blood (Blood that has leaked from the vessels) without promoting further bleeding. Together, they ensure that cooling the Blood does not trap stasis inside the body.

Notable synergies

The pairing of Shui Niu Jiao with Sheng Di Huang creates a powerful Blood-level Heat-clearing combination that simultaneously detoxifies and nourishes. The pairing of Chi Shao with Mu Dan Pi addresses the stasis dimension from two complementary angles: Chi Shao invigorates Blood flow while Mu Dan Pi disperses clotted Blood that has already left the vessels. The overall formula design embodies a key principle: cooling the Blood and dispersing stasis are used together so that Heat is cleared without leaving stasis behind, and stasis is dispersed without worsening bleeding.

How to Prepare

Traditional preparation instructions for Xi Jiao Di Huang Tang

Prepare as a decoction. In the original method from the Bei Ji Qian Jin Yao Fang, the four herbs are roughly cut, boiled in 9 sheng (approximately 1800 mL) of water, and reduced to 3 sheng (approximately 600 mL), then divided into three doses taken throughout the day.

In modern practice, Shui Niu Jiao (water buffalo horn) should be shaved into thin slices or ground into coarse powder and decocted first for 20 to 30 minutes before the remaining herbs are added. The other three herbs are then added and the decoction is cooked for a standard 20 to 30 minutes. Take warm, in 2 to 3 divided doses per day.

Common Modifications

How practitioners adapt Xi Jiao Di Huang Tang for specific situations

Added
Da Huang

6 - 9g, to purge Heat downward and clear accumulated Blood stasis from the intestines

Huang Qin

9 - 12g, to clear upper-body Heat and support Blood cooling

This is the original modification recorded in the source text. Da Huang purges accumulated Heat and stasis downward through the bowels, while Huang Qin clears Heat from the upper body, together addressing the manic agitation caused by combined Blood Heat and Yangming accumulation.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Xi Jiao Di Huang Tang should not be used or requires extra caution

Avoid

Yang deficiency bleeding (阳虚失血): Bleeding due to Spleen Yang deficiency failing to hold Blood in the vessels. This formula's cold nature would further damage Yang and worsen the bleeding.

Avoid

Spleen and Stomach deficiency-cold (脾胃虚弱): The strongly cold and Yin-nourishing nature of the formula can injure the Spleen and Stomach, causing poor appetite, bloating, and loose stools.

Caution

Yin deficiency with empty Heat: This formula treats excess Blood-level Heat. If bleeding is caused by Yin deficiency generating empty Heat rather than exuberant Heat toxins, this formula may deplete Yin further without addressing the root cause.

Caution

Qi deficiency bleeding: When bleeding arises from the Spleen's inability to control Blood (Qi failing to hold Blood), cold Blood-cooling herbs are inappropriate. Qi-tonifying formulas are needed instead.

Caution

Concurrent use of anticoagulant or antiplatelet medications: The Blood-moving herbs Mu Dan Pi and Chi Shao may potentiate bleeding risk when combined with pharmaceutical blood thinners such as warfarin or aspirin.

Caution

Pregnancy: Mu Dan Pi and Chi Shao have Blood-activating properties that may stimulate uterine contractions and increase miscarriage risk. See pregnancy safety notes.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Mu Dan Pi (Moutan Cortex) and Chi Shao (Red Peony Root) both activate Blood circulation and disperse stasis, which may stimulate uterine contractions and increase the risk of miscarriage or premature labor. The formula should only be considered during pregnancy in life-threatening situations where Blood-level Heat poses a greater immediate danger than the risks of treatment, and only under close medical supervision.

Breastfeeding

Use with caution during breastfeeding. The formula's strongly cold nature may potentially affect the nursing infant through breast milk, possibly causing digestive upset (loose stools or reduced appetite) in the baby. Mu Dan Pi and Chi Shao have Blood-activating properties whose transfer through breast milk has not been formally studied. If required for a serious Blood-Heat condition in the mother, short-term use under practitioner supervision is reasonable, but the infant should be monitored for signs of digestive disturbance or unusual fussiness.

Children

Xi Jiao Di Huang Tang has documented pediatric use, particularly for conditions like Henoch-Schönlein purpura (allergic purpura) in children. Dosages should be reduced proportionally based on age and body weight, typically to one-third to one-half the adult dose for children aged 6–12, and one-quarter for younger children. Because of the formula's strongly cold nature, pediatric use requires careful attention to the child's digestive function. If stomach discomfort, poor appetite, or loose stools develop, the formula should be modified with Spleen-protective additions (such as Sha Ren or Ji Nei Jin) or the dosage reduced. This formula should only be used in children when clear signs of Blood-level Heat are present and should be discontinued promptly once the acute condition resolves.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Xi Jiao Di Huang Tang

Anticoagulant and antiplatelet drugs (warfarin, heparin, aspirin, clopidogrel): Chi Shao (Red Peony Root) and Mu Dan Pi (Moutan Cortex) both activate Blood circulation and disperse stasis. When combined with pharmaceutical blood thinners, the risk of excessive bleeding may be increased. Patients on anticoagulant therapy should have their coagulation parameters monitored closely if this formula is prescribed.

Immunosuppressants: Because this formula is often used in conditions involving the immune system (such as allergic purpura or autoimmune bleeding disorders), concurrent use with immunosuppressive drugs may produce unpredictable interactions. Close medical coordination is advised.

NSAIDs (nonsteroidal anti-inflammatory drugs): Both the formula and NSAIDs may affect platelet function and bleeding tendency. Combined use could increase gastrointestinal bleeding risk, especially given that Sheng Di Huang is a cold herb that may already challenge digestive function.

Usage Guidance

Practical advice for getting the most out of Xi Jiao Di Huang Tang

Best time to take

Divided into 2–3 doses daily, taken warm on an empty stomach or between meals for optimal absorption. In acute emergencies, doses may be given more frequently as directed by the prescribing practitioner.

Typical duration

Acute use: typically 3–7 days, reassessed frequently. This is an emergency-grade formula for active Blood-level Heat and should be discontinued or modified once the acute condition stabilizes.

Dietary advice

While taking this formula, avoid hot, spicy, greasy, and fried foods, which can generate internal Heat and counteract the cooling action of the herbs. Alcohol should be strictly avoided as it heats the Blood. Favor cooling, easily digestible foods such as mung bean soup, pear, watermelon, cucumber, lotus root, and fresh leafy greens. Because the formula is strongly cold, those with fragile digestion should also limit raw, cold, and icy foods to prevent further burdening the Spleen and Stomach. Congee (rice porridge) is a good staple while taking this formula, as it supports digestion and fluid replenishment.

Xi Jiao Di Huang Tang originates from Bei Ji Qian Jin Yao Fang (備急千金要方) Táng dynasty, ~652 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Xi Jiao Di Huang Tang and its clinical use

《备急千金要方》(Bei Ji Qian Jin Yao Fang) — Sun Simiao:
Original indication: "治伤寒及温病应发汗而不汗之,内蓄血者,及鼻衄、吐血不尽,内余瘀血,面黄,大便黑,消瘀血方。"
Translation: "Treats cold damage and warm disease where sweating should have been induced but was not, resulting in internally accumulated Blood, as well as nosebleed and vomiting of blood that is not completely cleared, with remaining internal stasis, a yellow complexion, and black stools — a formula to dissolve Blood stasis."

《医宗金鉴·删补名医方论》(Yi Zong Jin Jian) — Wu Qian, 1742:
"吐血之因有三:曰劳伤,曰努伤,曰热伤。劳伤以理损为主;努损以去瘀为主;热伤以清热为主。热伤阳络则吐衄;热伤阴络则下血,是汤治热伤也。故用犀角清心去火之本,生地凉血以生新血,白芍敛血止血妄行,丹皮破血以逐其瘀。此方虽曰清火,而实滋阴;虽曰止血,而实去瘀。瘀去新生,阴滋火熄,可为探本穷源之法也。"
Translation: "There are three causes of vomiting blood: overwork injury, strain injury, and Heat injury. For overwork, treat the damage; for strain, remove stasis; for Heat, clear the Heat. When Heat injures the Yang network vessels, there is vomiting of blood and nosebleed; when it injures the Yin network vessels, there is bleeding below. This decoction treats Heat injury. Therefore, Rhinoceros Horn clears the Heart and removes the root of Fire; Sheng Di Huang cools the Blood and generates new Blood; Bai Shao restrains Blood and stops its reckless movement; Mu Dan Pi breaks Blood and expels stasis. Though this formula is said to clear Fire, it actually nourishes Yin; though it is said to stop bleeding, it actually removes stasis. When stasis is gone, the new is born; when Yin is nourished, Fire is extinguished — this may be called a method of tracing the root and exploring the source."

Ye Tianshi (叶天士), Qing dynasty Warm Disease master:
"入血就恐耗血动血,直须凉血散血。"
Translation: "Once [Heat] enters the Blood level, one fears it will consume and agitate the Blood — one must directly cool the Blood and disperse the Blood."

Historical Context

How Xi Jiao Di Huang Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Xi Jiao Di Huang Tang first appeared in Sun Simiao's Bei Ji Qian Jin Yao Fang (Essential Prescriptions Worth a Thousand Gold, c. 652 CE), recorded in Volume 12 under the section on vomiting blood. The original text described it for treating febrile diseases with internal Blood stasis, nosebleeds, bloody vomit, and black stools. It was also recorded in the Wai Tai Mi Yao (Arcane Essentials from the Imperial Library, 752 CE), which cited the earlier Xiao Pin Fang as its source.

The formula gained enormous importance during the Qing dynasty when the Warm Disease (Wen Bing) school systematized the four-level theory of febrile disease progression. Ye Tianshi (1667–1746) established the principle that Heat at the Blood level requires simultaneous cooling and dispersal of Blood, and Xi Jiao Di Huang Tang became the representative formula for this treatment strategy. Wu Qian's Yi Zong Jin Jian (1742) provided an influential commentary praising the formula's ability to simultaneously clear Fire, nourish Yin, stop bleeding, and remove stasis. Numerous variant versions appeared in later texts, including modifications in the Jing Yue Quan Shu, Jiao Zhu Fu Ren Liang Fang, and Jiang Xue Yuan Gu Fang Xuan Zhu, each adapting the base formula for specific clinical situations.

In modern times, rhinoceros horn (Xi Jiao) has been replaced by water buffalo horn (Shui Niu Jiao) due to the international ban on rhinoceros products under CITES. The substitution requires a significantly larger dose (typically 30–60g of water buffalo horn versus the original 30g of rhinoceros horn) and prolonged decocting to approximate the original effect. The modern name "Qing Re Di Huang Tang" (清热地黄汤) is sometimes used to reflect this substitution.

Modern Research

A published study investigating the pharmacological effects or clinical outcomes of Xi Jiao Di Huang Tang

1

Systematic Review Protocol: Efficacy and Safety of Xijiao Dihuang Decoction in Treating Henoch-Schönlein Purpura (2021)

Kong Z, Zheng J, Ou J, Zhou X, Wu J, Huang H. Medicine. 2021; 100(51): e28268.

This systematic review protocol aimed to evaluate the combined use of Xijiao Dihuang decoction with standard Western treatment for Henoch-Schönlein purpura (allergic purpura), a common childhood vascular inflammatory disease. The protocol planned comprehensive searches across major international and Chinese medical databases to assess clinical effectiveness and safety.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.