Qing Wei San

Clear the Stomach Powder · 清胃散

Also known as: Coptis and Rehmannia Formula

A classical formula used to clear excess heat from the Stomach that flares upward, causing toothache, swollen or bleeding gums, mouth sores, bad breath, and facial flushing. It works by draining Stomach Fire while cooling the Blood to address the inflammation and pain in the mouth and face.

Origin Lan Shi Mi Cang (《兰室秘藏》Secrets from the Orchid Chamber) by Li Dongyuan (李东垣) — Jīn dynasty (金朝), c. 1276 CE
Composition 5 herbs
Huang Lian
King
Huang Lian
Sheng Ma
Deputy
Sheng Ma
Shu Di Huang
Deputy
Shu Di Huang
Mu Dan Pi
Deputy
Mu Dan Pi
Dang Gui
Assistant
Dang Gui
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qing Wei San is designed to correct these specific patterns.

Why Qing Wei San addresses this pattern

This is the primary pattern Qing Wei San was designed to treat. Accumulated Heat in the Stomach blazes upward along the Yangming channels (the Stomach channel reaches the upper gums, the Large Intestine channel reaches the lower gums), attacking the teeth, gums, lips, cheeks, and face. The Heat scorches the Blood, causing inflammation, bleeding, and tissue damage in the oral cavity. Huang Lian directly clears the Stomach Fire, Sheng Ma vents the depressed Heat and guides the formula to the affected area, while Sheng Di Huang and Mu Dan Pi cool the Blood that has been damaged by the upward-flaring Fire. Dang Gui nourishes Blood to support recovery.

A practitioner would look for one or more of these signs

Toothache

Severe, with preference for cold and aversion to hot on the affected teeth

Bleeding Gums

Spontaneous gum bleeding or bleeding on slight pressure

Swollen Gums

Red, swollen, possibly ulcerated gums

Bad Breath

Hot, foul-smelling breath from Stomach Heat

Sore

Ulceration of the lips, tongue, or inner cheeks

Facial Flushing

Heat and redness of the cheeks

Headaches

Headache pulled upward by the tooth pain along the channel

Dry Mouth

Dry mouth and tongue from Heat consuming fluids

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Qing Wei San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM distinguishes toothache by its underlying pattern. Stomach Fire toothache is marked by intense pain that prefers cold and worsens with heat, often accompanied by red swollen gums, bad breath, and facial flushing. The Stomach channel (foot Yangming) enters the upper teeth, while the Large Intestine channel (hand Yangming) enters the lower teeth, so when Heat accumulates in the Stomach, it follows these channels upward to attack the teeth and gums. This is considered an Excess-type toothache, distinct from the dull, lingering tooth pain of Kidney Yin Deficiency (where the Kidneys fail to nourish the bones and teeth) or the sharp pain of Wind-Cold invasion.

Why Qing Wei San Helps

Qing Wei San directly targets the root cause: Stomach Fire. Huang Lian, bitter and cold, drains accumulated Fire from the Stomach. Sheng Ma guides the formula along the Yangming channel to the teeth and face while also venting the trapped Fire so it can disperse. Sheng Di Huang and Mu Dan Pi cool the Blood that has been heated by the Fire, reducing gum inflammation and bleeding. Dang Gui nourishes the Blood and helps reduce swelling. The combined effect rapidly lowers the Heat driving the toothache while addressing the tissue damage it has caused.

Also commonly used for

Swollen Gums

Gingivitis and periodontitis with red, swollen, bleeding gums

Bleeding Gums

Gingival bleeding due to Stomach Fire

Nosebleeds

Epistaxis from Stomach Fire flaring upward

Vaginal Pain

Trigeminal neuralgia with signs of Stomach Heat

Acne

Facial acne from Yangming channel Heat

What This Formula Does

Every TCM formula has a specific set of actions — here's what Qing Wei San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Qing Wei San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Qing Wei San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Qing Wei San works at the root level.

The core disease mechanism addressed by Qing Wei San is Stomach Fire flaring upward (胃火上攻, wèi huǒ shàng gōng). In this pattern, excessive Heat accumulates in the Stomach, then follows the Yangming channel pathway upward to attack the mouth, teeth, gums, and face.

The Foot Yangming (Stomach) channel runs through the upper gums, while the Hand Yangming (Large Intestine) channel reaches the lower gums. When Heat becomes exuberant in these channels, it blazes upward along these pathways, causing intense toothache, swollen and bleeding gums, facial flushing, foul breath, and mouth sores. Because the Stomach is described classically as an organ abundant in both Qi and Blood (多气多血之腑), when Stomach Heat is severe it readily burns into the Blood level, scorching the blood vessels of the gums and oral tissues. This explains the bleeding, ulceration, and tissue breakdown that accompany the condition.

The pattern may arise from dietary excess (spicy, greasy, or rich foods), overconsumption of warming or tonifying medicines (as Li Dongyuan specifically noted), or internal factors that generate Heat in the middle burner. The Heat dries fluids, producing thirst and dry mouth, while the rising Fire produces the characteristic preference for cold drinks and cold applied to the teeth. This combination of Stomach Fire in the Qi level and Heat entering the Blood level is precisely what Qing Wei San is designed to address.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter and sweet, with the bitter taste dominating to drain Fire and dry Dampness, balanced by sweet and cool herbs that nourish Yin and cool the Blood.

Ingredients

5 herbs

The herbs that make up Qing Wei San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Huang Lian

Huang Lian

Coptis rhizome

Dosage 6 - 9g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen

Role in Qing Wei San

The bitter, cold nature of Huang Lian directly drains Fire from the Stomach. As the sovereign herb, it addresses the root cause of the pattern by clearing accumulated Heat from the Yangming channel, thereby alleviating toothache, gum inflammation, and oral ulceration.
Deputies — Assists and enhances the King
Sheng Ma

Sheng Ma

Bugbane rhizome

Dosage 3 - 6g
Temperature Slightly Cool
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Spleen, Stomach, Large Intestine

Role in Qing Wei San

Sheng Ma clears Heat and resolves toxins while its light, ascending nature allows depressed Fire to vent outward and disperse, embodying the principle of 'when Fire is depressed, release it.' Combined with Huang Lian, it ensures Fire is drained without cold stagnation, while its own dispersing action does not fan the flames higher. It also serves as a channel-guiding herb for the Yangming (Stomach) channel, directing the formula to the head and face.
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 6 - 12g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Qing Wei San

Raw Rehmannia cools the Blood and nourishes Yin. Stomach Heat readily damages the Blood level, causing bleeding gums and dry mouth. Sheng Di Huang cools Blood-level Heat and replenishes the fluids damaged by the Fire, supporting the main therapeutic goal from the Yin and Blood perspective.
Mu Dan Pi

Mu Dan Pi

Tree peony root bark

Dosage 6 - 9g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys

Role in Qing Wei San

Moutan bark cools the Blood and clears Heat, while also dispelling Blood stasis. It works alongside Sheng Di Huang to address Heat that has entered the Blood level, helping to reduce gum swelling, stop bleeding, and resolve inflammation.
Assistant — Supports or moderates other herbs
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 6 - 9g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Qing Wei San

Dang Gui nourishes and harmonizes the Blood. In the context of this formula, it prevents the bitter-cold herbs from further damaging the Blood, and its blood-moving quality helps reduce swelling and alleviate pain. Working with Sheng Di Huang, it nourishes Yin and Blood; working with Mu Dan Pi, it helps disperse stagnation to relieve swelling.

Why This Combination Works

How the herbs in Qing Wei San complement each other

Overall strategy

This formula treats Stomach Fire that blazes upward along the Yangming channels to the head and face, scorching the Blood and causing pain, swelling, and bleeding in the teeth and gums. The prescription strategy combines bitter-cold draining of Stomach Fire with cooling and nourishing the Blood, while also applying the classical principle of venting depressed Fire ('fire depressed, release it') to ensure complete resolution without cold stagnation.

King herb

Huang Lian (Coptis) is the undisputed King. Its bitter, cold nature directly targets the Stomach, making it the most effective single herb for draining accumulated Stomach Fire. It attacks the root cause of the pattern: excessive Heat in the Yangming channel system.

Deputy herbs

Sheng Ma (Cimicifuga) serves a dual role. It clears Heat and resolves toxins while its light, upward-moving nature vents the depressed Fire outward so it can dissipate rather than smolder. Sheng Di Huang (raw Rehmannia) and Mu Dan Pi (Moutan bark) together cool the Blood level. Since the Stomach is described as a 'fu organ of copious Qi and Blood,' Stomach Fire readily damages Blood, causing gum bleeding, inflammation, and tissue destruction. These two herbs address this secondary Blood-Heat dimension.

Assistant herbs

Dang Gui (Chinese Angelica root) is a reinforcing assistant. It nourishes and invigorates the Blood, preventing the cold, bitter herbs from injuring the Blood and Body Fluids. Together with Mu Dan Pi, its mild blood-moving action helps resolve the swelling and pain. Together with Sheng Di Huang, it supports Yin and Blood replenishment.

Notable synergies

The most celebrated pairing is Huang Lian with Sheng Ma. Huang Lian drains Fire downward by its bitter, cold descending nature, while Sheng Ma disperses Fire outward and upward. Together, they ensure that draining does not cause cold stagnation, and dispersing does not fan the flames higher. This combination is classically described as: 'Huang Lian gains Sheng Ma and drains Fire without cold obstruction; Sheng Ma gains Huang Lian and disperses Fire without fanning it higher.' The pairing of Sheng Di Huang with Mu Dan Pi creates a strong Blood-cooling unit, while Dang Gui bridges between the Blood-cooling and Blood-nourishing actions of the formula.

How to Prepare

Traditional preparation instructions for Qing Wei San

The original method calls for grinding the herbs into a fine powder and combining them into a single dose. Add approximately 300 ml of water and decoct until reduced to about 200 ml. Strain and allow to cool before drinking. The formula should be taken at a cool or room temperature (not hot), which is consistent with its Heat-clearing function.

In modern practice, this formula is more commonly prepared as a standard decoction (Tang): combine the herbs in a ceramic or glass pot with approximately 500 ml of water, soak for 20-30 minutes, then bring to a boil and simmer for 20 minutes. Strain and divide the liquid into two doses, taken morning and evening on a relatively empty stomach. Allow the decoction to cool to room temperature before drinking.

Common Modifications

How practitioners adapt Qing Wei San for specific situations

Added
Da Huang

6-9g, to purge Heat downward through the bowels

When Stomach Fire dries the intestines and causes constipation, adding Da Huang drains Heat downward and unblocks the bowels, providing an additional exit route for the accumulated Fire.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Qing Wei San should not be used or requires extra caution

Avoid

Toothache due to Wind-Cold invasion. This formula is designed for Heat patterns and would worsen Cold-type toothache where symptoms include preference for warmth and worsening with cold.

Avoid

Toothache or gum problems due to Kidney Deficiency (Kidney Yin or Yang Deficiency). Loose teeth, chronic dull aching, or receding gums from Kidney weakness require tonifying rather than clearing Heat.

Avoid

Spleen and Stomach Yang Deficiency or Cold patterns. The formula's predominantly cold and bitter nature can injure the Spleen and Stomach Yang in people who already have digestive weakness with cold signs.

Caution

Pregnancy. Mu Dan Pi (Moutan Bark) and Dang Gui (Angelica Sinensis) have Blood-moving properties and the formula's cold nature may be unsuitable during pregnancy.

Caution

Prolonged use. This is a clearing formula intended for acute conditions. Extended use can damage Stomach Qi and Spleen Yang, leading to digestive weakness.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Mu Dan Pi (Moutan Bark) has Blood-moving and Blood-cooling properties that may theoretically stimulate uterine activity. Dang Gui (Angelica Sinensis) also moves Blood. While these herbs are present in modest doses in this formula, the combination warrants caution. The formula's overall cold nature is also a concern, as excessively cold medicinals are generally avoided during pregnancy. Consult a qualified practitioner before use during pregnancy.

Breastfeeding

Limited specific data exists on breastfeeding safety. Huang Lian (Coptis) contains berberine, which is known to transfer into breast milk in small amounts. Berberine has historically been used with caution in nursing mothers because of its intensely bitter and cold nature, which could theoretically affect the infant's digestion. Mu Dan Pi and Sheng Di Huang are generally considered low-risk. As this formula is typically used short-term for acute conditions, brief use under practitioner guidance is likely acceptable, but prolonged use during breastfeeding should be avoided. Consult a qualified practitioner.

Children

Qing Wei San can be used in children for Stomach Fire conditions such as gum swelling and mouth sores. The classical text Yi Zong Jin Jian (《医宗金鉴》) specifically records a variant of this formula for treating childhood gum swelling (重龈, chóng yín), where heat accumulates in the Stomach causing water-blister-like swelling at the tooth roots. Dosage should be reduced according to age and body weight, typically to one-third to one-half of the adult dose for children over 6 years old, and one-quarter for younger children. Because Huang Lian is very bitter and cold, prolonged use in children should be avoided to protect the developing digestive system. The decoction can be sweetened slightly if needed to improve compliance, though excessive sweetening should be avoided.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Qing Wei San

Huang Lian (Coptis/berberine) and anticoagulant or antiplatelet drugs: Berberine, the primary active alkaloid in Huang Lian, has been shown in pharmacological studies to compete for plasma protein binding sites with warfarin, potentially increasing free warfarin concentration and enhancing its anticoagulant effect. A case report documented subcutaneous petechiae in a patient taking warfarin with a Huang Lian-containing formula. Berberine has also been identified as a direct thrombin inhibitor in vitro. Patients on warfarin or other anticoagulants should use this formula with caution and with medical monitoring of INR values.

Huang Lian (berberine) and CYP450-metabolized drugs: Berberine has been shown to inhibit several cytochrome P450 enzymes (particularly CYP3A4 and CYP2D6) and may affect the metabolism of drugs processed through these pathways. This is relevant for many common medications including certain statins, calcium channel blockers, and immunosuppressants such as cyclosporine.

Huang Lian (berberine) and hypoglycemic agents: Berberine has demonstrated independent blood-glucose-lowering effects. When combined with metformin or other oral hypoglycemic agents, there is a theoretical risk of additive hypoglycemia. Blood sugar monitoring is advisable.

Usage Guidance

Practical advice for getting the most out of Qing Wei San

Best time to take

On an empty stomach, or 30–60 minutes before meals, taken cool or at room temperature (not hot), 2 times per day.

Typical duration

Acute use: 3–7 days, reassessed as symptoms resolve. Not intended for long-term use.

Dietary advice

Avoid spicy, hot, greasy, and fried foods, which can further generate Stomach Heat and worsen the condition. Alcohol and strong coffee should also be avoided, as they are warming and can aggravate Fire. Rich and heavy meats (especially lamb and other warming proteins) should be reduced. Favor cooling, bland foods such as mung bean soup, congee, cucumber, watermelon, pear, and tofu. Room-temperature or slightly cool water is preferable. The classical instruction is to take the decoction after it has cooled (放冷服之), not while hot, which aligns with the treatment principle of clearing Heat.

Qing Wei San originates from Lan Shi Mi Cang (《兰室秘藏》Secrets from the Orchid Chamber) by Li Dongyuan (李东垣) Jīn dynasty (金朝), c. 1276 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Qing Wei San and its clinical use

From the Lan Shi Mi Cang (《兰室秘藏》, Secrets from the Orchid Chamber) by Li Dongyuan:

「治因服补胃热药,致使上下牙疼痛不可忍,牵引头脑、满面发热,大痛。足阳明之别络入脑,喜寒恶热,乃是手足阳明经中热盛而作也。其齿喜冷恶热。」

"Treats [toothache caused by] taking warming, tonifying Stomach medicines, resulting in unbearable pain in the upper and lower teeth, pulling pain radiating to the head, heat across the entire face, and severe pain. The divergent collateral of the Foot Yangming [channel] enters the Brain. [The patient] prefers cold and dislikes heat. This is caused by exuberant Heat in the Hand and Foot Yangming channels. The teeth prefer cold and dislike heat."

Formula verse (方歌, fāng gē):

「清胃散中当归连,生地丹皮升麻全,或加石膏泻胃火,能消牙痛与牙宣。」

"In Qing Wei San are Dang Gui and [Huang] Lian, with Sheng Di, Dan Pi, and Sheng Ma complete. Add Shi Gao [Gypsum] if needed to drain Stomach Fire, and it can resolve toothache and gum bleeding."

Historical Context

How Qing Wei San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Qing Wei San was created by Li Gao (李杲, 1180–1251), better known as Li Dongyuan (李东垣), one of the four great masters of the Jin-Yuan medical era. Li Dongyuan is most famous as the founder of the "Spleen-Stomach School" (脾胃学派) of Chinese medicine, which emphasized the central importance of digestive function in health and disease. He studied under Zhang Yuansu of the Yishui (易水) school and developed his ideas during the turbulent final decades of the Jin Dynasty.

The formula appears in both the Pi Wei Lun (《脾胃论》, Treatise on the Spleen and Stomach, 1249) and the Lan Shi Mi Cang (《兰室秘藏》, Secrets from the Orchid Chamber, published 1276). The title "Lan Shi" (Orchid Chamber) alludes to the Su Wen chapter "Ling Lan Mi Dian Lun," suggesting the work contained teachings of great value. While Li Dongyuan is most closely associated with tonifying Spleen Qi and raising Yang, Qing Wei San shows the other side of his clinical thinking: his skill at using bitter-cold and Blood-cooling herbs for excess Heat conditions. Notably, the original text states the formula treats toothache specifically caused by taking warming, tonifying Stomach medicines, revealing Li's awareness that overuse of warming treatments could generate pathological Heat.

The formula was later included in China's official List of 100 Classical Formulas (古代经典名方目录第一批) for modern research and development, reflecting its enduring clinical importance. Over the centuries, it has been recorded and discussed in over 100 classical medical texts, with its indications expanding beyond toothache to encompass a wide range of oral, dermatological, and digestive conditions, though the unifying pathomechanism remains Stomach Fire flaring upward.

Modern Research

2 published studies investigating the pharmacological effects or clinical outcomes of Qing Wei San

1

Qingwei San treats oral ulcer subjected to stomach heat syndrome in db/db mice by targeting TLR4/MyD88/NF-κB pathway (Preclinical study, 2022)

Liang J, et al. Chinese Medicine, 2022, 17(1):3.

This preclinical study used diabetic (db/db) mice to model oral ulcers with stomach heat syndrome. QWS treatment promoted ulcer healing, reduced inflammatory infiltration in gastric and oral mucosa, and suppressed pro-inflammatory signaling through the TLR4/MyD88/NF-κB pathway. Network pharmacology analysis identified key bioactive components and multiple anti-inflammatory targets.

PubMed
2

Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis (Computational and in vitro study, 2025)

BMC Complementary Medicine and Therapies, 2025.

This study used computational systems pharmacology to identify bioactive components of QWS relevant to periodontitis. Key compounds including ethyl ferulate, methyl protocatechuate, and quercetin were found to significantly reduce expression levels of inflammatory factors in an in vitro inflammatory model, supporting the formula's traditional use for gum inflammation.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.