Xie Huang San

Drain the Yellow Powder · 泻黄散

Also known as: Xie Pi San (泻脾散, Drain the Spleen Powder)

A classical pediatric formula used to clear hidden heat from the Spleen and Stomach. It is commonly used for mouth sores, bad breath, dry lips, excessive hunger, and the childhood habit of protruding the tongue. The formula gently disperses smoldering heat rather than aggressively purging it, making it suitable for both children and adults with these symptoms.

Origin Xiao Er Yao Zheng Zhi Jue (小儿药证直诀, Key to Therapeutics of Children's Diseases) by Qian Yi (钱乙) — Sòng dynasty, 1119 CE
Composition 5 herbs
Shi Gao
King
Shi Gao
Zhi Zi
King
Zhi Zi
Fang Feng
Deputy
Fang Feng
Huo Xiang
Assistant
Huo Xiang
Gan Cao
Envoy
Gan Cao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Xie Huang San is designed to correct these specific patterns.

Why Xie Huang San addresses this pattern

Xie Huang San directly targets the pattern of hidden or smoldering fire lodged in the Spleen and Stomach (脾胃伏火). In this pattern, heat becomes trapped in the Middle Burner rather than manifesting as obvious, overt fever. The Spleen governs the mouth and its health is reflected in the lips, so when internal fire simmers in the Spleen, it rises to the mouth causing sores, bad breath, and dry, cracked lips. Shi Gao and Zhi Zi clear the accumulated heat, while Fang Feng vents and disperses the hidden fire outward. Huo Xiang revives normal Spleen function, and Gan Cao harmonizes and protects the Middle Burner. This combination clears heat without damaging the Spleen's digestive capacity.

A practitioner would look for one or more of these signs

Sore

Recurrent oral ulcers from Spleen heat rising to the mouth

Bad Breath

Foul mouth odor from smoldering internal heat

Dry Lips

Dry, cracked, or peeling lips

Excessive Hunger

Irritable hunger with frequent appetite, heat consuming fluids

Thirst

Vexing thirst from internal heat damaging fluids

Tongue Protrusion In Children

Children repeatedly sticking out the tongue (Spleen heat 'biting tongue')

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Xie Huang San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Spleen and Stomach Heat Stomach Heat or Fire

TCM Interpretation

In TCM, recurrent mouth sores (口疮) are most often linked to heat in the Spleen and Stomach channels. The Spleen 'opens to the mouth' and governs the flesh of the lips and oral cavity. When heat becomes lodged in the Spleen, it rises to the mouth and damages the delicate mucosal tissue, creating painful ulcers. This type of heat is often described as 'hidden' or 'smoldering' fire (伏火) because it does not always produce obvious signs like high fever. Instead, it manifests locally in the mouth as sores, bad breath, and dryness. The heat may also consume fluids, leading to thirst and a red tongue with a rapid pulse.

Why Xie Huang San Helps

Xie Huang San is considered a primary formula for mouth sores caused by Spleen/Stomach heat. Shi Gao directly clears the accumulated heat in the Yang Ming (Stomach) channel, while Zhi Zi clears heat and guides it downward for elimination. The critical ingredient is Fang Feng, which vents the hidden fire outward from the Spleen, dislodging heat that cold herbs alone cannot reach. Huo Xiang restores healthy Spleen function so that digestion is not impaired by the cooling herbs. This approach treats both the symptom (oral heat) and the root (smoldering Spleen fire), which is why it can address recurrent ulcers rather than just acute episodes.

Also commonly used for

Seborrheic Dermatitis

Facial seborrheic dermatitis with oily, red skin

Henoch-Schonlein Purpura

Allergic (Henoch-Schonlein) purpura in children

Hand Foot And Mouth Disease

Hand, foot and mouth disease in children

Poor Appetite In Children

Pediatric anorexia/poor appetite due to damp-heat

Acne

Acne and facial skin eruptions from Spleen/Stomach heat

Glossitis

Tongue inflammation or redness

Rosacea

Facial redness and flushing

What This Formula Does

Every TCM formula has a specific set of actions — here's what Xie Huang San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Xie Huang San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Xie Huang San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Xie Huang San works at the root level.

Xie Huang San addresses a pattern called "hidden Fire in the Spleen and Stomach" (脾胃伏火). In TCM, the Spleen governs the flesh and opens to the mouth, while the Stomach controls the lips. When Heat becomes trapped or "smolders" deep within the Spleen-Stomach system rather than manifesting as an obvious acute fever, it creates a distinctive set of problems. This trapped Heat steams upward to the mouth and lips, causing mouth sores (oral ulcers), bad breath, dry and cracked lips, and a dry mouth. Because the Heat irritates the digestive system, the person may feel restless, easily hungry, and excessively thirsty. In children, this hidden Spleen Heat can cause a characteristic behavior of repeatedly sticking out the tongue (called "tongue-play" or 弄舌 in TCM).

The word "hidden" (伏) is crucial. This is not a blazing surface Heat that can be simply cooled down with cold, bitter herbs. It is a Fire that has become trapped and depressed within the middle of the body. The classical principle guiding treatment here is "fire depressed, release it" (火郁发之), from the Su Wen. This means the strategy cannot rely on cold-natured herbs alone, which risk suppressing the Fire further and damaging the Spleen. Instead, the approach must combine clearing Heat with gently lifting and dispersing the trapped Fire outward, restoring the Spleen and Stomach's normal Qi movement so the Heat can be vented rather than locked in.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly acrid and sweet with a mild bitter note. The acrid Fang Feng and aromatic Huo Xiang disperse and uplift, the sweet Gan Cao harmonizes and protects the middle, and the bitter-cold Zhi Zi clears Heat downward.

Target Organs

Channels Entered

Ingredients

5 herbs

The herbs that make up Xie Huang San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Shi Gao

Shi Gao

Gypsum

Dosage 15g
Temperature Cold
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Stomach

Role in Xie Huang San

Cold and acrid, Shi Gao powerfully clears accumulated heat from the Stomach and the Yang Ming channel. It directly quenches the internal fire responsible for the core symptoms of mouth sores, thirst, and excessive hunger.
Zhi Zi

Zhi Zi

Gardenia fruit

Dosage 3g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, San Jiao (Triple Burner)

Role in Xie Huang San

Bitter and cold, Zhi Zi clears heat from the Heart and Lungs and directs it downward for elimination via urination. Working alongside Shi Gao, it drains accumulated heat from the Spleen and Stomach through the Triple Burner pathway.
Deputy — Assists and enhances the King
Fang Feng

Fang Feng

Siler root

Dosage 12g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Urinary Bladder, Liver, Spleen

Role in Xie Huang San

Used in the largest dose in the original formula, Fang Feng disperses and vents hidden fire from the Spleen channel outward. As a wind-dispersing herb, it lifts Yang Qi to release smoldering heat trapped in the Middle Burner, embodying the classical principle of 'when fire is constrained, release it' (火郁发之). It also restrains Wood (Liver) from overacting on Earth (Spleen).
Assistant — Supports or moderates other herbs
Huo Xiang

Huo Xiang

Patchouli herb

Dosage 5g
Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Spleen, Stomach, Lungs

Role in Xie Huang San

Aromatic and warm, Huo Xiang awakens and revitalizes the Spleen, transforming turbid dampness and harmonizing the Middle Burner. It prevents the cold and bitter heat-clearing herbs from damaging the Spleen's normal functioning.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 9g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Xie Huang San

Sweet in flavor, Gan Cao harmonizes the Middle Burner and moderates the actions of the other herbs. Its sweetness gently drains fire while protecting the Stomach, and it serves to coordinate the entire formula.

Why This Combination Works

How the herbs in Xie Huang San complement each other

Overall strategy

This formula addresses smoldering, hidden fire trapped within the Spleen and Stomach (脾胃伏火). Rather than simply purging heat with bitter-cold herbs, it combines direct heat-clearing with the dispersing action of wind herbs to vent the constrained fire outward, a strategy rooted in the Nei Jing principle that 'when fire is depressed, release it' (火郁发之).

King herbs

Shi Gao (Gypsum) and Zhi Zi (Gardenia) together form the primary heat-clearing core. Shi Gao, acrid and very cold, directly clears accumulated heat from the Stomach and Yang Ming channel. Zhi Zi, bitter and cold, clears heat from the Heart and Triple Burner and guides it downward for elimination through the urine. Together they drain the substantial heat that has accumulated in the Spleen and Stomach.

Deputy herbs

Fang Feng (Saposhnikovia) is the signature herb of this formula and carries the heaviest dose in the original text. Despite being a warm, acrid, wind-dispersing herb, it serves the crucial role of lifting and venting the hidden fire outward from the Spleen channel. This is the key strategic insight of the formula: using an ascending, dispersing herb to dislodge fire that is lodged deep and cannot be adequately reached by descending cold herbs alone. Additionally, Fang Feng's ability to spread Liver Qi helps prevent the Liver (Wood) from overacting on a weakened Spleen (Earth).

Assistant herbs

Huo Xiang (Agastache leaf) is an aromatic herb that revives and awakens Spleen function (reinforcing assistant). While the King herbs clear heat, Huo Xiang ensures the Spleen's normal Qi movement is restored rather than suppressed. Its aromatic nature disperses turbidity from the Middle Burner and prevents the cold medicinals from damaging the Spleen's digestive capacity.

Envoy herbs

Gan Cao (Licorice) harmonizes all the ingredients and protects the Middle Burner. Its sweet flavor gently drains fire while cushioning the Stomach from the bitter-cold properties of Zhi Zi and Shi Gao. It coordinates the ascending action of Fang Feng with the descending action of the King herbs.

Notable synergies

The pairing of Fang Feng with Shi Gao and Zhi Zi is the formula's defining synergy. The wind herb disperses outward while the cold herbs drain downward, creating a two-pronged strategy that addresses smoldering fire more effectively than either approach alone. The use of honey and wine in the original preparation method further supports this: honey moistens and moderates, while wine enhances the ascending, dispersing quality of the formula. Modern pharmacological research has confirmed that removing Fang Feng significantly weakens the formula's anti-inflammatory effect, demonstrating that its synergistic role is essential, not incidental.

How to Prepare

Traditional preparation instructions for Xie Huang San

The original method calls for slicing all the herbs, then lightly dry-frying them together with a small amount of honey and rice wine until aromatic. The mixture is then ground into a fine powder. Each dose is 3 to 6 grams of the powder, dissolved in one cup of water, decocted until half remains, then the clear liquid is taken warm. There is no fixed timing for administration.

In modern clinical practice, the formula is often prepared as a standard decoction using proportional dosages adapted from the original powder ratios, decocted in water for approximately 20 to 30 minutes.

Common Modifications

How practitioners adapt Xie Huang San for specific situations

Added
Huang Lian

3-6g, to directly clear Heart and Stomach fire

Shu Di Huang

9-12g, to cool Blood and nourish Yin damaged by heat

Huang Lian adds powerful bitter-cold heat-clearing to the formula, directly targeting intense Stomach fire, while Sheng Di Huang cools the Blood level and replenishes fluids consumed by the fire.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Xie Huang San should not be used or requires extra caution

Avoid

Yin deficiency with Heat. This formula is designed for excess-type hidden Fire in the Spleen and Stomach. Using it in patients whose Heat arises from Yin deficiency would further deplete Yin fluids without addressing the root cause.

Avoid

Children with congenital insufficiency or developmental delays causing tongue-protruding behavior. The original text specifically warns against using this formula when tongue-protruding (弄舌) results from constitutional deficiency rather than Spleen Heat.

Avoid

Spleen and Stomach deficiency Cold. If the digestive system is weakened by Cold rather than Heat, the cooling and draining herbs in this formula (Shi Gao, Zhi Zi) will further damage the Spleen Yang.

Caution

Mouth sores or oral symptoms due to Kidney Yin deficiency with deficiency Fire flaring upward. These require nourishing Yin and directing Fire downward, not draining Spleen Heat.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe with appropriate caution. The formula does not contain any strongly abortifacient or uterine-stimulating herbs. Zhi Zi (Gardenia) is cold-natured and should be used cautiously during pregnancy, and Shi Gao (Gypsum) is very cold. As a formula designed to clear Heat, prolonged use of its cold-natured ingredients could theoretically affect the Spleen's warming and holding functions needed during pregnancy. Short-term use under practitioner supervision is generally acceptable if the pattern clearly matches, but it should not be taken long-term during pregnancy without professional guidance.

Breastfeeding

No specific contraindication during breastfeeding. The herbs in this formula are commonly used in pediatric practice and do not contain known toxic substances that would pose a significant risk through breast milk. Shi Gao and Zhi Zi are cold-natured, so prolonged use by a nursing mother could theoretically affect breast milk quality by introducing excess cold into the system, potentially causing loose stools in the infant. Short-term use is generally considered acceptable when the pattern clearly warrants it. Practitioners should monitor for any digestive changes in the breastfeeding infant.

Children

Xie Huang San was originally designed for pediatric use by Qian Yi, one of the earliest specialists in children's medicine. It remains one of the most commonly referenced formulas in Chinese pediatric practice. The original dosing was in powdered form (散剂), with each dose being 3 to 6 grams of the powder dissolved in water and taken as a warm strained liquid. For modern decoction use, standard adult dosages should be reduced by approximately one-third to one-half for children aged 6 to 12, and by two-thirds or more for children under 6, depending on age and body weight. The formula is generally well-tolerated in children but should not be used long-term, as the cold-natured Shi Gao and Zhi Zi can weaken the Spleen if used excessively. Treatment is typically stopped once mouth sores and Heat signs resolve. Not suitable for infants with constitutional weakness, failure to thrive, or tongue-protruding due to developmental issues rather than Spleen Heat.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Xie Huang San

Gan Cao (Licorice): Glycyrrhizin in Gan Cao can cause pseudoaldosteronism (sodium retention, potassium loss, elevated blood pressure). It may interact with antihypertensive medications (reducing their effectiveness), diuretics (especially thiazides and loop diuretics, worsening potassium depletion), cardiac glycosides such as digoxin (hypokalemia increases digoxin toxicity), and corticosteroids (additive mineralocorticoid effects).

Shi Gao (Gypsum, calcium sulfate): As a calcium-containing mineral, Shi Gao may reduce the absorption of tetracycline antibiotics, fluoroquinolones, and bisphosphonates if taken simultaneously. Separate administration by at least 2 hours is advisable.

Zhi Zi (Gardenia fruit): Contains geniposide, which has hepatoprotective but also potential hepatotoxic effects at high doses. Caution is warranted when combined with hepatotoxic drugs (such as acetaminophen/paracetamol in high doses or certain statins), particularly with prolonged use.

Usage Guidance

Practical advice for getting the most out of Xie Huang San

Best time to take

Between meals (approximately 30 minutes before or 1 hour after meals). The original text specifies 无时 ("without fixed time"), meaning it can be taken at any time as needed.

Typical duration

Short-term use: typically 5 to 14 days. Reassess once mouth sores heal and Heat signs resolve; not intended for long-term continuous use.

Dietary advice

While taking this formula, avoid foods that generate internal Heat or Dampness-Heat, including greasy, fried, and heavily spiced foods, alcohol, and excessive sweets. These can worsen the smoldering Heat in the Spleen and Stomach that the formula is designed to clear. Favor bland, easily digestible foods such as congee (rice porridge), lightly cooked vegetables, mung beans, winter melon, and pear, which help clear Heat and protect digestive function. Cold and raw foods should also be consumed in moderation, as they can impair Spleen function even when Heat is present. The classical preparation calls for honey and wine in processing, suggesting the formula was designed to be gentle on the Spleen, so dietary choices should likewise support this balance.

Xie Huang San originates from Xiao Er Yao Zheng Zhi Jue (小儿药证直诀, Key to Therapeutics of Children's Diseases) by Qian Yi (钱乙) Sòng dynasty, 1119 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Xie Huang San and its clinical use

《小儿药证直诀》 (Craft of Medicinal Treatment for Childhood Disease Patterns):
「治脾热弄舌。」
"Treats Spleen Heat [causing] tongue-protruding behavior."

《医方考》 (Yi Fang, Investigations of Medical Formulas):
「此足太阴阳明药也。」
"This is a formula for the Foot Tai Yin [Spleen] and Yang Ming [Stomach] channels."

Commentary tradition (attributed to Zhang Shanlei 张山雷):
「为脾胃蕴热而设。」
"Designed for accumulated Heat smoldering in the Spleen and Stomach."

Classical principle reflected in this formula, from 《素问·六元正纪大论》 (Su Wen):
「火郁发之。」
"When Fire is depressed [and smoldering within], release it outward."

Historical Context

How Xie Huang San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Xie Huang San was created by Qian Yi (钱乙, c. 1032–1113), the Song Dynasty physician widely regarded as the founder of systematic Chinese pediatric medicine. His landmark work, the Xiao Er Yao Zheng Zhi Jue (小儿药证直诀, Craft of Medicinal Treatment for Childhood Disease Patterns), compiled by his student Yan Xiaozhong and published around 1119, established a "five-organ" approach to pediatric diagnosis and treatment. Xie Huang San (also called Xie Pi San, "Drain the Spleen Powder") was one of a famous set of organ-targeted formulas Qian Yi created: Xie Qing Wan for the Liver, Xie Bai San for the Lungs, Dao Chi San for the Heart, and Xie Huang San for the Spleen. Each formula exemplified his philosophy of treating children with precise, targeted prescriptions rather than harsh adult formulas.

What makes Xie Huang San theoretically remarkable is its heavy use of Fang Feng (the largest ingredient by weight). Later commentators recognized this as a masterful application of the Nei Jing principle "fire depressed, release it" (火郁发之). Rather than simply using bitter-cold herbs to suppress the Heat, Qian Yi used the wind-dispersing Fang Feng to "lift" the hidden Fire out of the Spleen. Li Dongyuan (Li Gao), the founder of the Spleen-Stomach school in the subsequent Jin-Yuan period, was deeply influenced by Qian Yi's strategy of using wind herbs to scatter depressed Fire, incorporating similar ideas into formulas like Sheng Yang San Huo Tang and Bu Zhong Yi Qi Tang. Ming Dynasty pediatrician Wan Quan further codified Xie Huang San's place, prescribing it specifically for Spleen Heat conditions in children.