Formula

Qing Wei San

Coptis & Rehmannia Formula | 清胃散

Also known as:

Clear the Stomach Powder , Clear the Stomach Fire Powder

Properties

Heat-clearing formulas · Cold

Key Ingredients

Huang Lian

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula*

Traditional Chinese Medicine background and properties

Formula Description*

A classical formula used to clear excess heat from the Stomach that flares upward, causing toothache, swollen or bleeding gums, mouth sores, bad breath, and facial flushing. It works by draining Stomach Fire while cooling the Blood to address the inflammation and pain in the mouth and face.

Formula Category*

Main Actions*

  • Clears Stomach Heat
  • Cools the Blood
  • Nourishes Yin
  • Resolves Toxicity
  • Disperses Depressed Heat

TCM Patterns*

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qing Wei San is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Qing Wei San addresses this pattern

This is the primary pattern Qing Wei San was designed to treat. Accumulated Heat in the Stomach blazes upward along the Yangming channels (the Stomach channel reaches the upper gums, the Large Intestine channel reaches the lower gums), attacking the teeth, gums, lips, cheeks, and face. The Heat scorches the Blood, causing inflammation, bleeding, and tissue damage in the oral cavity. Huang Lian directly clears the Stomach Fire, Sheng Ma vents the depressed Heat and guides the formula to the affected area, while Sheng Di Huang and Mu Dan Pi cool the Blood that has been damaged by the upward-flaring Fire. Dang Gui nourishes Blood to support recovery.

A practitioner would look for one or more of these signs

Toothache

Severe, with preference for cold and aversion to hot on the affected teeth

Bleeding Gums

Spontaneous gum bleeding or bleeding on slight pressure

Swollen Gums

Red, swollen, possibly ulcerated gums

Bad Breath

Hot, foul-smelling breath from Stomach Heat

Sore

Ulceration of the lips, tongue, or inner cheeks

Facial Flushing

Heat and redness of the cheeks

Headaches

Headache pulled upward by the tooth pain along the channel

Dry Mouth

Dry mouth and tongue from Heat consuming fluids

How It Addresses the Root Cause*

The core disease mechanism addressed by Qing Wei San is Stomach Fire flaring upward (胃火上攻, wèi huǒ shàng gōng). In this pattern, excessive Heat accumulates in the Stomach, then follows the Yangming channel pathway upward to attack the mouth, teeth, gums, and face.

The Foot Yangming (Stomach) channel runs through the upper gums, while the Hand Yangming (Large Intestine) channel reaches the lower gums. When Heat becomes exuberant in these channels, it blazes upward along these pathways, causing intense toothache, swollen and bleeding gums, facial flushing, foul breath, and mouth sores. Because the Stomach is described classically as an organ abundant in both Qi and Blood (多气多血之腑), when Stomach Heat is severe it readily burns into the Blood level, scorching the blood vessels of the gums and oral tissues. This explains the bleeding, ulceration, and tissue breakdown that accompany the condition.

The pattern may arise from dietary excess (spicy, greasy, or rich foods), overconsumption of warming or tonifying medicines (as Li Dongyuan specifically noted), or internal factors that generate Heat in the middle burner. The Heat dries fluids, producing thirst and dry mouth, while the rising Fire produces the characteristic preference for cold drinks and cold applied to the teeth. This combination of Stomach Fire in the Qi level and Heat entering the Blood level is precisely what Qing Wei San is designed to address.

Formula Properties*

Temperature

Cold

Taste Profile

Predominantly bitter and sweet, with the bitter taste dominating to drain Fire and dry Dampness, balanced by sweet and cool herbs that nourish Yin and cool the Blood.

Target Organs
Stomach Large Intestine
Channels Entered
Stomach Large Intestine

Formula Origin

Lan Shi Mi Cang (《兰室秘藏》Secrets from the Orchid Chamber) by Li Dongyuan (李东垣)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Supplier Information

Treasure of the East

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Ingredients in Qing Wei San

Detailed information about each herb in Qing Wei San and their roles

Kings
Deputies
Assistants
Huang Lian
Huang Lian

Coptis rhizome

Dosage: 6 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen
Parts Used Rhizome (根茎 gēn jīng)
Role in Qing Wei San

The bitter, cold nature of Huang Lian directly drains Fire from the Stomach. As the sovereign herb, it addresses the root cause of the pattern by clearing accumulated Heat from the Yangming channel, thereby alleviating toothache, gum inflammation, and oral ulceration.

Sheng Ma
Sheng Ma

Cimicifuga rhizome

Dosage: 3 - 6g

Temperature Slightly Cool
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Spleen, Stomach, Large Intestine
Parts Used Rhizome (根茎 gēn jīng)
Role in Qing Wei San

Sheng Ma clears Heat and resolves toxins while its light, ascending nature allows depressed Fire to vent outward and disperse, embodying the principle of 'when Fire is depressed, release it.' Combined with Huang Lian, it ensures Fire is drained without cold stagnation, while its own dispersing action does not fan the flames higher. It also serves as a channel-guiding herb for the Yangming (Stomach) channel, directing the formula to the head and face.

Shu Di Huang
Shu Di Huang

Prepared Rehmannia root

Dosage: 6 - 12g

Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Qing Wei San

Raw Rehmannia cools the Blood and nourishes Yin. Stomach Heat readily damages the Blood level, causing bleeding gums and dry mouth. Sheng Di Huang cools Blood-level Heat and replenishes the fluids damaged by the Fire, supporting the main therapeutic goal from the Yin and Blood perspective.

Mu Dan Pi
Mu Dan Pi

Tree peony root bark

Dosage: 6 - 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in Qing Wei San

Moutan bark cools the Blood and clears Heat, while also dispelling Blood stasis. It works alongside Sheng Di Huang to address Heat that has entered the Blood level, helping to reduce gum swelling, stop bleeding, and resolve inflammation.

Dang Gui
Dang Gui

Chinese Angelica root

Dosage: 6 - 9g

Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Parts Used Root (根 gēn)
Role in Qing Wei San

Dang Gui nourishes and harmonizes the Blood. In the context of this formula, it prevents the bitter-cold herbs from further damaging the Blood, and its blood-moving quality helps reduce swelling and alleviate pain. Working with Sheng Di Huang, it nourishes Yin and Blood; working with Mu Dan Pi, it helps disperse stagnation to relieve swelling.

Modern Research (2 studies)

  • Qingwei San treats oral ulcer subjected to stomach heat syndrome in db/db mice by targeting TLR4/MyD88/NF-κB pathway (Preclinical study, 2022)
  • Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis (Computational and in vitro study, 2025)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

On an empty stomach, or 30–60 minutes before meals, taken cool or at room temperature (not hot), 2 times per day.

Typical Duration

Acute use: 3–7 days, reassessed as symptoms resolve. Not intended for long-term use.

Dietary Advice

Avoid spicy, hot, greasy, and fried foods, which can further generate Stomach Heat and worsen the condition. Alcohol and strong coffee should also be avoided, as they are warming and can aggravate Fire. Rich and heavy meats (especially lamb and other warming proteins) should be reduced. Favor cooling, bland foods such as mung bean soup, congee, cucumber, watermelon, pear, and tofu. Room-temperature or slightly cool water is preferable. The classical instruction is to take the decoction after it has cooled (放冷服之), not while hot, which aligns with the treatment principle of clearing Heat.

Modern Usage*

Qing Wei San is classified as a Heat-clearing formula and has the effects of clearing Heat from the internal organs, specifically the Stomach, and cooling the Blood. It is primarily used for toothache caused by Stomach Fire.
Symptoms include toothache that radiates to the head, facial heat, a preference for cold and an aversion to heat in the affected teeth, bleeding gums, red and swollen gums that may ulcerate, swelling and pain in the lips, tongue, cheeks, and jaw, foul breath, dry mouth and tongue, a red tongue with a yellow coating, and a slippery, rapid pulse.
Clinically, this formula is often used to treat conditions such as stomatitis and periodontitis that are attributed to the upward attack of Stomach Fire.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Special Populations

Pregnancy

Use with caution during pregnancy. Mu Dan Pi (Moutan Bark) has Blood-moving and Blood-cooling properties that may theoretically stimulate uterine activity. Dang Gui (Angelica Sinensis) also moves Blood. While these herbs are present in modest doses in this formula, the combination warrants caution. The formula's overall cold nature is also a concern, as excessively cold medicinals are generally avoided during pregnancy. Consult a qualified practitioner before use during pregnancy.

Breastfeeding

Limited specific data exists on breastfeeding safety. Huang Lian (Coptis) contains berberine, which is known to transfer into breast milk in small amounts. Berberine has historically been used with caution in nursing mothers because of its intensely bitter and cold nature, which could theoretically affect the infant's digestion. Mu Dan Pi and Sheng Di Huang are generally considered low-risk. As this formula is typically used short-term for acute conditions, brief use under practitioner guidance is likely acceptable, but prolonged use during breastfeeding should be avoided. Consult a qualified practitioner.

Pediatric Use

Qing Wei San can be used in children for Stomach Fire conditions such as gum swelling and mouth sores. The classical text Yi Zong Jin Jian (《医宗金鉴》) specifically records a variant of this formula for treating childhood gum swelling (重龈, chóng yín), where heat accumulates in the Stomach causing water-blister-like swelling at the tooth roots. Dosage should be reduced according to age and body weight, typically to one-third to one-half of the adult dose for children over 6 years old, and one-quarter for younger children. Because Huang Lian is very bitter and cold, prolonged use in children should be avoided to protect the developing digestive system. The decoction can be sweetened slightly if needed to improve compliance, though excessive sweetening should be avoided.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.